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Diogo Miguel Barros Bitoque. Concluiu o(a) Doutoramento em Mecanismos de Doença e Medicina Regenerativa (associação) em 2018/05 pelo(a) Universidade do Algarve, Doutoramento em Mecanismos de Doença e Medicina Regenerativa (associação) em 2018/05 pelo(a) Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Mestrado em Ciências Biomédicas em 2013/12 pelo(a) Universidade do Algarve - Campus de Gambelas e Licenciatura em Ciências Biomédicas em 2011 pelo(a) Universidade do Algarve - Campus de Gambelas. É Investigador Contratado no(a) Universidade Nova de Lisboa Faculdade de Ciências Médicas. Publicou 8 artigos em revistas especializadas. Coorientou 1 trabalho(s) de conclusão de curso de licenciatura/bacharelato. Participa e/ou participou como Investigador em 1 projeto(s). Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Biotecnologia Médica com ênfase em Biomateriais. Nas suas atividades profissionais interagiu com 67 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Terapia Génica; Polímero; Poliplexos; Retina; RPE; D407; Gene therapy; PDMAEMA; Gene transfer; Vector trafficking; Ciências Médicas; Ciências biomédicas; Genoma humano; Olhos; Terapia génica; Polímeros; Polymers; Eye; Chitosan; Diabetic Retinopathy; VEGF; GLUT1; Renin; Synuclein; Ageing; Retinitis Pigmentosa; NLS; PDE6B; rd10; Hyaluronic acid; Liposome; Antioxidant; Nanofiber; Biosafety; MGM; OGM; .
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Identification

Personal identification

Full name
Diogo Miguel Barros Bitoque

Citation names

  • Diogo B. Bitoque

Author identifiers

Ciência ID
D81C-6457-7F28
ORCID iD
0000-0002-6536-6578

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Biomaterials

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
Education
Degree Classification
2014/01 - 2018/05
Concluded
 Mecanismos de Doença e Medicina Regenerativa (associação) (Doutoramento)
Major in Sem especialidade
Universidade do Algarve, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
"UNDERSTANDING THE POTENTIAL OF PDMAEMA-BASED VECTORS FOR GENE THERAPY OF THE RETINA" (THESIS/DISSERTATION)
 Muito Bom
2011/09 - 2013/12
Concluded
 Ciências Biomédicas (Mestrado)
Universidade do Algarve - Campus de Gambelas, Portugal
"Synthesis and evaluation of polymer nanoparticles for delivery in RPE cells" (THESIS/DISSERTATION)
 18
2008 - 2011
Concluded
 Ciências Biomédicas (Licenciatura)
Universidade do Algarve - Campus de Gambelas, Portugal
 15
Affiliation

Science

Category
Host institution 		Employer
2022/04/15 - Current Contracted Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2019/03/15 - 2021/11/30 Contracted Researcher (Research) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
Projects

Contract

Designation Funders
2022/09/01 - Current NovaGo
NovaGo Therapeutics AG
Principal investigator
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
 NovaGo
Ongoing
2021/01/01 - 2025/12/31 Life Sciences for a Healthy and Sustainable Future
LA/P/0087/2020
Universidade Nova de Lisboa Microbiologia Molecular Estrutural e Celular, Portugal

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Fundação Calouste Gulbenkian, Portugal

Instituto Gulbenkian de Ciência, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

BioResources 4 Sustainability, Portugal

Universidade NOVA de Lisboa, Portugal

iNOVA4Health, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2022/01/01 - 2022/12/31 Exploring the therapeutic potential of RBP3 in retinal gene therapy
EXPL/BTM-ORG/0500/2021
Co-Principal Investigator (Co-PI)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/09/01 - 2021/08/31 Terapia Génica para tratamento de retinopatia diabética
PTDC/BTM-ORG/28121/2017
Researcher
Universidade Nova de Lisboa, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 iNOVA4Health - Programme in Translational Medicine (iBET, CEDOC/FCM, IPOLFG and ITQB)
UID/Multi/04462/2019
Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Instituto de Biologia Experimental e Tecnológica, Portugal

Universidade NOVA de Lisboa NOVA Medical School, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. Diogo B. Bitoque; Raquel L. Sequeira; Ana M. Rosa da Costa; Gabriela A. Silva. "PAEMA nonviral vectors display enhanced gene transfer ability in retinal cells". Paper presented in ARVO 2021 Annual Meeting, 2021.
    Published
  2. Daniela F. Santos; Diogo B. Bitoque; Raquel L. Sequeira; Brigite Cabrita; Sónia Simão; Gabriela A. Silva. "ACE2-overexpression protects RPE cells from inflammation and oxidative stress". Paper presented in ARVO 2021 Annual Meeting, 2021.
    Published
  3. Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "PDMAEMA non-viral vectors efficiently express PDE6ß in the rd10 mouse model of Retinitis Pigmentosa". Paper presented in ARVO 2019 Annual Meeting, Vancouver, 2019.
    Published
  4. Sónia Simão; Bitoque, Diogo; Daniela F. Santos; Inês M. Araújo; Gabriela Araújo Silva. "Deregulation of the retinal renin-angiotensin system precedes the onset of diabetic retinopathy". Paper presented in 53rd EASD Annual Meeting, Lisboa, 2017.
    Published
  5. Sónia Simão; Bitoque, Diogo; Sofia M. Calado; Gabriela Araújo Silva. "Increased expression of (pro)renin and (pro)renin receptor correlates with the progression of diabetic retinopathy". Paper presented in 16th EURETINA Congress in Copenhagen, Copenhaga, 2016.
    Published
  6. Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "PDMAEMA as gene therapy vector: an intracellular insight". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Finnish Society of Gene Therapy (FSGT) Collaborative Congress 2015, Helsínquia, 2015.
    Published
  7. Sofia M. Calado; Liliana Alves; Sónia Simão; Bitoque, Diogo; Gabriela Araújo Silva. "The role of GLUT1 in the pathogenesis of Diabetic Retinopathy". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Finnish Society of Gene Therapy (FSGT) Collaborative Congress 2015, Helsínquia, 2015.
    Published
  8. Sónia Simão; Bitoque, Diogo; Sofia M. Calado; Gabriela Araújo Silva. "Anti-angiogenic VEGF isoform is markedly decreased in the retina of diabetic mice". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Netherlands Society of Gene and Cell Therapy (NVGCT) Collaborative Congress 2014, Haia, 2014.
    Published
  9. Bitoque, Diogo; Ana Vanessa Oliveira; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "Dependence of gene transfer efficiency on the composition of PDMAEMA polyplexes". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Netherlands Society of Gene and Cell Therapy (NVGCT) Collaborative Congress 2014, Haia, 2014.
    Published
  10. Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "PDMAEMA is an efficient retinal gene therapy vector". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Spanish Society for Gene Therapy (SETGyC) Collaborative Congress 2013, Madrid, 2013.
    Published
  11. Ana Vanessa Oliveira; Bitoque, Diogo; Gabriela Araújo Silva. "Chitosan-hyaluronic acid hybrid vectors for retinal gene therapy". Paper presented in American Society of Gene and Cell Therapy (ASGCT) Annual Meeting 2012, Philadelphia, 2012.
    Published
  12. Bitoque, Diogo; Andreia Silva; Margarita Romero-Durán; Ana Vanessa Oliveira; Eduardo M. Lopes; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "pDMAEMA-Based polyplexes as vectors for retinal gene therapy". Paper presented in American Society of Gene and Cell Therapy (ASGCT) Annual Meeting 2012, Philadelphia, 2012.
    Published
  13. Ana Vanessa Oliveira; Andreia Silva; Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "Optimizing chitosan–based vectors for ocular gene therapy". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and British Society for Gene and Cell Therapy (BSGCT) Collaborative Congress 2011, 2011.
    Published
Conference poster
  1. Beatriz F. Vaz; Alexandra M. L. Oliveira; Cláudia F. Fernandes; Diogo B. Bitoque; Gabriela A. Silva. "Using microscopy tools to study the potential of RBP3 as a therapeutic approach for retinal diseases". Paper presented in Spanish Portuguese Meeting for Advanced Optical Microscopy, 2023.
  2. Diogo B. Bitoque; Raquel L. Sequeira; Ana M. Rosa da Costa; Gabriela A. Silva. "PAEMA nonviral vectors display enhanced gene transfer ability in retinal cells". Paper presented in ARVO 2021 Annual Meeting, 2021.
  3. Daniela F. Santos; Diogo B. Bitoque; Raquel L. Sequeira; Brigite Cabrita; Sónia Simão; Gabriela A. Silva. "ACE2-overexpression protects RPE cells from inflammation and oxidative stress". Paper presented in ARVO 2021 Annual Meeting, 2021.
  4. Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "PDMAEMA non-viral vectors efficiently express PDE6ß in the rd10 mouse model of Retinitis Pigmentosa". Paper presented in ARVO 2019 Annual Meeting, 2019.
  5. Jeniffer Farias dos Santos; Filipa Pires; Bitoque, Diogo; Gabriela Araújo Silva; Alexandre Marletta; Paulo Ribeiro; Jorge Carvalho Silva; Maria de Fátima Raposo; Viviane Abreu Nunes Cerqueira Dantas. "Antioxidant effect of EGCG-liposome functionalized electrospun nanofibers: perspectives for wound healing". Paper presented in 48th Annual Meeting of the Brazilian Society for Biochemistry and Molecular Biology (SBBq), 2019.
  6. Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "Human-derived NLS improve the efficiency of chitosan as a gene transfer vehicle". Paper presented in 2nd NMS Symposium on Chronic Diseases and Translational Science 2018, 2018.
  7. Bitoque, Diogo; Daniela F. Santos; Rute Araújo; Gabriela Araújo Silva. "In vitro tools to model Retinitis Pigmentosa". Paper presented in The 12th Meeting of the UK Eye Genetics Group & the 20th Meeting of The International Society for Genetic Eye Diseases & Retinoblastoma, 2017.
  8. Sónia Simão; Bitoque, Diogo; Daniela F. Santos; Inês M. Araújo; Gabriela Araújo Silva. "Deregulation of the retinal renin-angiotensin system precedes the onset of diabetic retinopathy". Paper presented in 53rd EASD Annual Meeting, 2017.
  9. Gabriela Santos; João Martins; Sofia M. Calado; Bitoque, Diogo; Raquel Bóia; Tiago F. Outeiro; Gabriela Araújo Silva; Sandra Tenreiro. "Synuclein levels and distribution are altered in mouse retinal neurons with ageing and diabetic retinopathy". Paper presented in XV Meeting of the Portuguese Society for Neuroscience, 2017.
  10. Sónia Simão; Bitoque, Diogo; Sofia M. Calado; Gabriela Araújo Silva. "Increased expression of (pro)renin and (pro)renin receptor correlates with the progression of diabetic retinopathy". Paper presented in 16th EURETINA Congress in Copenhagen, 2016.
  11. Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "PDMAEMA as gene therapy vector: an intracellular insight". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Finnish Society of Gene Therapy (FSGT) Collaborative Congress 2015, 2015.
  12. Sofia M. Calado; Liliana Alves; Sónia Simão; Bitoque, Diogo; Gabriela Araújo Silva. "The role of GLUT1 in the pathogenesis of Diabetic Retinopathy". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Finnish Society of Gene Therapy (FSGT) Collaborative Congress 2015, 2015.
  13. Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "PDMAEMA as gene therapy vector: insights on its intracellular pathway". Paper presented in Advanced Summer School, The Nano / Medicine Interface, 2015.
  14. Bitoque, Diogo; Ana Vanessa Oliveira; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "Dependence of gene transfer efficiency on the composition of PDMAEMA polyplexes". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Netherlands Society of Gene and Cell Therapy (NVGCT) Collaborative Congress 2014, 2014.
  15. Sónia Simão; Bitoque, Diogo; Sofia M. Calado; Gabriela Araújo Silva. "Anti-angiogenic VEGF isoform is markedly decreased in the retina of diabetic mice". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Netherlands Society of Gene and Cell Therapy (NVGCT) Collaborative Congress 2014, 2014.
  16. Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "PDMAEMA is an efficient retinal gene therapy vector". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and Spanish Society for Gene Therapy (SETGyC) Collaborative Congress 2013, 2013.
  17. Bitoque, Diogo; Sónia Simão; Sofia M. Calado; Susana Machado; Catarina Afonso; Ana Vanessa Oliveira; Gabriela Araújo Silva. "Hybrid Strategies for Retinal Gene Therapy". Paper presented in 8th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies, 2013.
  18. Ana Vanessa Oliveira; Bitoque, Diogo; Gabriela Araújo Silva. "Chitosan-hyaluronic acid hybrid vectors for retinal gene therapy". Paper presented in American Society of Gene and Cell Therapy (ASGCT) Annual Meeting 2012, 2012.
  19. Bitoque, Diogo; Andreia Silva; Margarita Romero-Dúran; Ana Vanessa Oliveira; Eduardo Lopes; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "PDMAEMA as a delivery vector for gene therapy of the retina". Paper presented in American Society of Gene and Cell Therapy (ASGCT) Annual Meeting 2012, 2012.
  20. Ana Vanessa Oliveira; Andreia Silva; Bitoque, Diogo; Ana Maria Rosa da Costa; Gabriela Araújo Silva. "Optimizing chitosan–based vectors for ocular gene therapy". Paper presented in European Society of Gene and Cell Therapy (ESGCT) and British Society for Gene and Cell Therapy (BSGCT) Collaborative Congress 2011, 2011.
Journal article
  1. Diogo B. Bitoque; Sofia M. Calado; Ana M. Rosa da Costa; Gabriela A. Silva. "Nonviral PDMAEMA Vectors Efficiently Express PDE6beta in a Mouse Model of Retinitis Pigmentosa". bioRxiv (2023):
    Accepted
  2. sepehr talebian; Bárbara Mendes; João Conniot; Syamak Farajikhah; Fariba Dehghani; Zhongyan Li; Diogo Bitoque; et al. "Biopolymeric Coatings for Local Release of Therapeutics from Biomedical Implants". Advanced Science (2023): 2207603-2207603. http://dx.doi.org/10.1002/advs.202207603.
    10.1002/advs.202207603
  3. Sarah Batista Dias; Luísa de Lemos; Luís Sousa; Diogo B. Bitoque; Gabriela Araújo Silva; Miguel C. Seabra; Sandra Tenreiro. "Age-Related Changes of the Synucleins Profile in the Mouse Retina". Biomolecules (2023): https://doi.org/10.3390/biom13010180.
    10.3390/biom13010180
  4. Bitoque, Diogo B.; Fernandes, Cláudia F.; Oliveira, Alexandra M. L.; Silva, Gabriela A.. "Strategies to Improve the Targeting of Retinal Cells by Non-Viral Gene Therapy Vectors". Frontiers in Drug Delivery 2 (2022): http://dx.doi.org/10.3389/fddev.2022.899260.
    10.3389/fddev.2022.899260
  5. Mónica Machado; Alexandra M. L. Oliveira; Gabriela A. Silva; Diogo B. Bitoque; Joana Tavares Ferreira; Luís Abegão Pinto; Quirina Ferreira. "Graphene Biosensors—A Molecular Approach". Nanomaterials (2022): https://doi.org/10.3390/nano12101624.
    10.3390/nano12101624
  6. Alexandra M. L. Oliveira; Mónica Machado; Gabriela A. Silva; Diogo B. Bitoque; Joana Tavares Ferreira; Luís Abegão Pinto; Quirina Ferreira. "Graphene Oxide Thin Films with Drug Delivery Function". Nanomaterials 12 7 (2022): 1149-1149. https://doi.org/10.3390/nano12071149.
    10.3390/nano12071149
  7. Rute S. Araújo; Diogo B. Bitoque; Gabriela A. Silva. "Development of strategies to modulate gene expression of angiogenesis-related molecules in the retina". Gene 791 (2021): 145724-145724. https://doi.org/10.1016/j.gene.2021.145724.
    10.1016/j.gene.2021.145724
  8. Diogo B. Bitoque, Sr.; Joana Morais; Ana V. Oliveira; Raquel L. Sequeira; Sofia M. Calado; Tiago M. Fortunato; Sonia Simao; Ana M. Rosa da Costa; Gabriela A. Silva. "Human-derived NLS enhance the gene transfer efficiency of chitosan". Bioscience Reports 41 1 (2021): https://doi.org/10.1042/BSR20201026.
    Open access • Published • 10.1042/BSR20201026
  9. Almeida, A.C.; Bitoque, D.B.; Martins, C.; Coelho, C.; Borrego, L.M.; Silva, G.A.. "Serum levels of placental growth factor reflect the severity of retinopathy of prematurity". Acta Paediatrica, International Journal of Paediatrics 110 10 (2021): 2778-2779. http://www.scopus.com/inward/record.url?eid=2-s2.0-85108276369&partnerID=MN8TOARS.
    10.1111/apa.15976
  10. Araújo, R.S.; Bitoque, D.B.; Silva, G.A.. "Dual-Acting Antiangiogenic Gene Therapy Reduces Inflammation and Regresses Neovascularization in Diabetic Mouse Retina". Molecular Therapy - Nucleic Acids 22 (2020): 329-339. http://www.scopus.com/inward/record.url?eid=2-s2.0-85091668524&partnerID=MN8TOARS.
    10.1016/j.omtn.2020.08.036
  11. Machado, M.; Silva, G.A.; Bitoque, D.B.; Ferreira, J.; Pinto, L.A.; Morgado, J.; Ferreira, Q.. "Self-Assembled Multilayer Films for Time-Controlled Ocular Drug Delivery". ACS Applied Bio Materials 2 10 (2019): 4173-4180. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073247173&partnerID=MN8TOARS.
    10.1021/acsabm.9b00417
  12. Pires, F.; Santos, J.F.; Bitoque, D.; Silva, G.A.; Marletta, A.; Nunes, V.A.; Ribeiro, P.A.; Silva, J.C.; Raposo, M.. "Polycaprolactone/Gelatin Nanofiber Membranes Containing EGCG-Loaded Liposomes and Their Potential Use for Skin Regeneration". ACS Applied Bio Materials 2 11 (2019): 4790-4800. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073054841&partnerID=MN8TOARS.
    10.1021/acsabm.9b00524
  13. Diogo B. Bitoque; Gabriela A. Silva. "Molecular biology tools for the study and therapy of PDE6ß mutations". Journal of Biotechnology 284 (2018): 1-5. https://doi.org/10.1016/j.jbiotec.2018.07.030.
    10.1016/j.jbiotec.2018.07.030
  14. Bitoque, D.B.; Rosa da Costa, A.M.; Silva, G.A.. "Insights on the intracellular trafficking of PDMAEMA gene therapy vectors". Materials Science and Engineering C 93 (2018): 277-288. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050853877&partnerID=MN8TOARS.
    10.1016/j.msec.2018.07.071
  15. Bitoque, D.B.; Simão, S.; Oliveira, A.V.; Machado, S.; Duran, M.R.; Lopes, E.; da Costa, A.M.R.; Silva, G.A.. "Efficiency of RAFT-synthesized PDMAEMA in gene transfer to the retina". Journal of Tissue Engineering and Regenerative Medicine 11 1 (2017): 265-275. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902237241&partnerID=MN8TOARS.
    10.1002/term.1909
  16. Ana V. Oliveira; Diogo B. Bitoque; Gabriela A. Silva. "Combining Hyaluronic Acid with Chitosan Enhances Gene Delivery". Journal of Nanomaterials 2014 (2014): 1-9. http://dx.doi.org/10.1155/2014/246347.
    10.1155/2014/246347
  17. Machado S; Calado S; Bitoque D; Oliveira AV; Øpstad CL; Zeeshan M; Sliwka HR; et al. "Cationic polyene phospholipids as DNA carriers for ocular gene therapy.". (2014): http://europepmc.org/abstract/med/25147812.
    10.1155/2014/703253
  18. Oliveira, A.V.; Silva, A.P.; Bitoque, D.B.; Silva, G.A.; Rosa Da Costa, A.M.. "Transfection efficiency of chitosan and thiolated chitosan in retinal pigment epithelium cells: A comparative study". Journal of Pharmacy and Bioallied Sciences 5 2 (2013): 111-118. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878622079&partnerID=MN8TOARS.
    10.4103/0975-7406.111823
Thesis / Dissertation
  1. Bitoque, Diogo Miguel Barros. "Understanding the potential of pdmaema-based vectors for gene therapy of the retina". PhD, 2018. http://hdl.handle.net/10362/39613.
  2. Bitoque, Diogo B.. "Synthesis and evaluation of polymer nanoparticles for delivery in RPE cells". Master, 2013. http://hdl.handle.net/10400.1/6054.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10/27 Segmentation and quantification of blood vessels and similar network-like structures using machine learning Spanish & Portuguese Advanced Optical Microscopy
Portuguese and Spanish Advanced Optical Microscopy networks (Faro, Portugal)
2022/03/10 Retinol-binding protein 3: a potential tool for gene therapy in retinal degeneration 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies
Portuguese Society for Stem Cells and Cell Therapies (Braga)
2021/10/11 Automated measurement of retinal thickness in rd16 mice using spectral-domain coherence tomography 3rd NMS Symposium on Chronic Diseases and Translational Science
NOVA Medical School (Lisbon, Portugal)
2021/07/18 PAEMA nonviral vectors display enhanced gene transfer ability in retinal cells Pan-American Research Day (PARD)
Pan-American Association of Ophthalmology (United States)
2019/04/27 PDMAEMA non-viral vectors efficiently express PDE6ß in the rd10 mouse model of Retinitis Pigmentosa Pan-American Research Day (PARD)
Pan-American Association of Ophthalmology (Vancouver, Canada)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020/09/01 - 2021/12/17 Retinol-binding protein 3: a potential tool for gene therapy in retinal degeneration
Supervisor
 Mestrado em Biotecnologia Farmacêutica (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019 - 2019 Caracterização de murganhos rd16 como modelo para o estudo da amaurose congénita de Leber
Supervisor
 Biologia Celular e Molecular (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2016/01/05 - 2016/03/07 Gene therapy in ocular diseases
Co-supervisor
 Biologia Celular e Molecular (Degree)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/02 - 2015/04 Characterization of the physicochemical properties of PDMAEMA:HA non-viral vectors
Co-supervisor
 Mestrado Integrado em Medicina (Other)
Universidade do Algarve - Campus de Gambelas, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019/01 - 2019/11/15 Lisbon Area Post Doc meeting (2019/11/14 - 2019/11/15)
Conference
 Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal

Instituto de Medicina Molecular, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Fundação Champalimaud, Portugal

Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/11/03 - 2021/11/05 Genotyping for identifying genes that cause ciliopathies
Workshop
 LYSOCIL Staff Exchange 8
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2019/09/27 - 2019/12/16 Blended Learning International Entrepreneurship Experience (BLUES program)
Workshop
 Blended Learning International Entrepreneurship Experience (BLUES program)
Universidade Nova de Lisboa, Portugal
2018/12/04 - 2018/12/04 Training session on "Portuguese Legislation on Animal use in Research"
Seminar
 Training session on "Portuguese Legislation on Animal use in Research"
Fundação Champalimaud, Portugal
2016/10/17 - 2016/10/19 Biosafety Course in level 2 and level 3 laboratories
Workshop
 Biosafety Course in level 2 and level 3 laboratories
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2016/06/27 - 2016/06/30 Practical Course on Animal Use
Workshop
 Practical Course on Animal Use
Fundação Champalimaud, Portugal
2016/06/21 - 2016/06/24 Research Skills Development (RSD) 20th Edition
Workshop
 Research Skills Development (RSD) 20th Edition
NOVA Doctoral School, Universidade Nova de Lisboa, Portugal
2016/02/29 - 2016/03/04 Advanced Course in Vision Sciences (25h)
Workshop
 Advanced Course in Vision Sciences (25h)
Universidade de Coimbra, Portugal
2015/06/29 - 2015/07/03 The Nano/Medicine interface has been raising considerable interest in recent years. Based on this interface, novel techniques, research and therapeutic approaches are being developed. This Summer School brought closer immunologists, cell biologists, medical doctors and biomaterial scientists to discuss what is becoming an exciting and stimulating new interdisciplinary area of research.
Workshop
 Interrogations at the Biointerface, The Nano / Medicine Interface
Universidade do Porto, Portugal
2012 - 2012 Online Theoretical Course of Sciences in Laboratory Animals (20h)
Workshop
 Online Theoretical Course of Sciences in Laboratory Animals (20h)
Portuguese Society of Sciences in Laboratory Animals (SPCAL), Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/06/23 Assessment of low molecular weight phenolic metabolites effect on a yeast alphaSyn-GFP Parkinson disease model
(Thesis) Main arguer
 Pedro Maria Cardoso Machado (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2023/06/19 Polyphenol metabolites impact on yeast Parkinson's disease model
(Thesis) Main arguer
 Fátima José Jesus de Andrade (Other)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Committee member

Activity description
Role 		Institution / Organization
2016/02/03 - Current Membro do Comité de Biossegurança e Boas Práticas Laboratoriais
Member
 Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/02/02 - 2023/02/09 CONGENTO LAS Course for Upgrade to Function B on Animal Use Congento Consortium for Genetically Tractable Organisms, Portugal
2022/02 - 2022/06 Introdução à Medicina Regenerativa Mestrado Integrado em Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/03 - 2022/03 Regeneração de Tecidos Mestrado em Engenharia Biomédica (Mestrado) Instituto Politécnico de Setúbal Escola Superior de Saúde, Portugal
2021/02 - 2021/06 Introdução à Medicina Regenerativa Mestrado Integrado em Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/03 - 2021/03 Regeneração de Tecidos Mestrado em Engenharia Biomédica (Mestrado) Instituto Politécnico de Setúbal Escola Superior de Saúde, Portugal
2020/02 - 2020/06 Introdução à Medicina Regenerativa Mestrado Integrado em Medicina (Mestrado integrado) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2022/01 - 2022/01 Bioengineered Taylor & Francis Online
2022/01 - 2022/01 Life Sciences Elsevier
2021/04 - 2021/04 The European Journal of Pharmacology Elsevier
2020/05 - 2020/05 Biotechnology Reports (2215-017X) Elsevier
2019/06 - 2019/06 International Journal of Clinical and Experimental Ophthalmology Heighten Science Publications Corporation
2018/06 - 2018/06 RSC Advances (2046-2069) The Royal Society of Chemistry

Mentoring / Tutoring

Topic Student name
2022/09/01 - Current RBP3 in retinal gene therapy as a direct therapeutic approach Beatriz Vaz Fernandes
2019/09/01 - 2020/12/29 Optimizing nonviral vectors for gene therapy of the retina Raquel Lourenço das Neves Sequeira
2019/09 - 2019/09 Gene Therapy as a new therapeutic approach for Diabetic Retinopathy Eleni Bouziani
2019/07 - 2019/07 Gene Therapy as a new therapeutic approach for Diabetic Retinopathy Boris Delpire
2018/09 - 2018/09 Gene Therapy as a new therapeutic approach for Diabetic Retinopathy Maria Ciobanu
2017/07/03 - 2017/07/28 Gene Therapy as a new therapeutic approach for Diabetic Retinopathy Plamena Todorova