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Fernando André Pereira Marques Durães. Completed the Doutoramento in PhD in Pharmaceutical Sciences in 2023/02/01 by Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Doutoramento in PhD in Pharmaceutical Sciences in 2023/02/01 by Universidade do Porto Faculdade de Farmácia and Mestrado in Integrated Masters in Pharmaceutical Sciences in 2014 by Universidade do Porto Faculdade de Farmácia. Is Researcher in Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental. Published 17 articles in journals. Has received 2 awards and/or honors. Participates and/or participated as Research Fellow in 1 project(s). Works in the area(s) of Exact Sciences with emphasis on Chemical Sciences with emphasis on Organic Chemistry, Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Medicinal Chemistry, Exact Sciences with emphasis on Chemical Sciences, Natural sciences with emphasis on Biological Sciences with emphasis on Microbiology and Natural sciences with emphasis on Earth and Environmental Sciences with emphasis on Environmental Sciences. In their professional activities interacted with 90 collaborator(s) co-authorship of scientific papers.
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Identification

Personal identification

Full name
Fernando André Pereira Marques Durães

Citation names

  • Durães, Fernando

Author identifiers

Ciência ID
D81C-CA93-8E42
ORCID iD
0000-0003-4201-2774

Knowledge fields

  • Exact Sciences - Chemical Sciences - Organic Chemistry
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
  • Exact Sciences - Chemical Sciences
  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Earth and Environmental Sciences - Environmental Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2016/12 - 2023/02/01
Concluded
 PhD in Pharmaceutical Sciences (Doutoramento)
Major in Organic and Pharmaceutical Chemistry
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Universidade do Porto Faculdade de Farmácia, Portugal
"Target-based and Phenotypic Studies towards the Discovery of Antimicrobial Adjuvants" (THESIS/DISSERTATION)
2014/01/14 - 2014/04/15
Concluded
 Production, crystallization and inhibition by polysulfated small molecules of coagulation Factor IXa¿ (Outros)
Universität Salzburg, Austria
 A
2014
Concluded
 Integrated Masters in Pharmaceutical Sciences (Mestrado)
Universidade do Porto Faculdade de Farmácia, Portugal
"n/a" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2023/02/15 - Current Research Assistant (Research) University of Southampton School of Chemistry, United Kingdom
2016/12 - 2023/02/01 Researcher (Research) Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
(...)
Projects

Grant

Designation Funders
2019/11 - 2022/10 The two faces of bacterial efflux pumps: antimicrobial resistance in health and aquatic pollution
Provided by PTCRIS: SFRH/BD/144681/2019
 Fundação para a Ciência e a Tecnologia
2018/07 - 2021/09 Antimicrobials from the sea: models for innovative agents to revert multidrug resistance
Provided by PTCRIS: PTDC/SAU-PUB/28736/2017
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2022/02/15 - Current Caught in the act: Aptablotting for decoding the signals by two component systems
N/A
Research Fellow
Leverhulme Trust
Ongoing
2018/11/01 - 2019/10/31 Antimicrobials from the sea
POCI-01-0145- FEDER-028736
Research Fellow
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
Ongoing
Outputs

Publications

Conference paper
  1. Durães, Fernando; Neves, Ana Rita; Joana Freitas-Silva; Annamaria Kincses; Eugénia Pinto; Paulo Martins da Costa; Madalena M. M. Pinto; et al. "Steroid derivatives: A promising class of bacterial efflux pump inhibitors?". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
  2. Joana Moreira; Durães, Fernando; Joana Freitas-Silva; Nikoletta Szemerédi; Eugénia Pinto; Paulo Martins da Costa; Madalena M. M. Pinto; et al. "New chalcone analogues with potential bacterial efflux pump inhibitory effect". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
  3. Durães, Fernando; Barbosa, Filipa; Freitas-Silva, Joana; Costa, Paulo; Pinto, Madalena; Sousa, Emília. "In silico studies of bacterial efflux pump inhibition by thioxanthones and their synergistic antibacterial activity". 2019.
    10.3390/ecmc2019-06300
  4. Durães, Fernando; Palmeira, Andreia; Pinto, Madalena; Sousa, Emília. "In silico studies of aminated thioxanthones: bacterial multidrug efflux pumps vs P-glycoprotein". 2018.
    10.3390/ecmc-4-05598
Conference poster
  1. Joana Freitas-Silva; Darlan Nakayama; Durães, Fernando; Joana Moreira; Ana Rita Neves; Filipa Barbosa; Diana Resende; et al. "Antimicrobials from the sea: inspiring models to revert multidrug resistance". Paper presented in Blue Think Conference, Virtual Conference, 2020.
  2. Durães, Fernando; Filipa Barbosa; Joana Freitas-Silva; Madalena Pinto; Eugénia Pinto; Paulo Costa; Emília Sousa. "Design, synthesis and antimicrobial activity of potential modulators of bacterial efflux pumps". Paper presented in 13th National Meeting of Organic Chemistry/ 6th National Meeting of Therapeutic Chemistry (13ºENQO/6ºENQT), 2020.
  3. Durães, Fernando; Joana Moreira; Ana Rita Neves; Filipa Barbosa; Joana Freitas-Silva; Honorina Cidade; Marta Correia-da-Silva; et al. "Antimicrobials from the Sea: Models for Innovative Agents to Revert Multidrug Resistance". Paper presented in Day of the Microbiology Laboratory, Faculty of Pharmacy, University of Porto, 2019.
  4. Durães, Fernando; Barbosa, Filipa; Freitas-Silva, Joana; Cravo, Sara; Costa, Paulo; Pinto, Madalena; Sousa, Emília. "From the computer to the lab bench: design, synthesis and synergistic antibacterial activity of aminated thioxanthones". Paper presented in EUROPIN Summer School on Drug Design, Vienna, Austria, 2019.
  5. Durães, Fernando; Barbosa, Filipa; Pinto, Madalena; Sousa, Emília. "Unforeseen tandem Ullmann type C – N coupling and dehydrative cyclization of a thioxanthone and guanidine". Paper presented in XXVI Encontro Nacional da Sociedade Portuguesa de Química, Porto, Portugal, 2019.
  6. Barbosa, Filipa; Durães, Fernando; Pinto, Eugénia; Pinto, Madalena; Sousa, Emília. "Synthesis of thioxanthone derivatives to revert drug resistance". Paper presented in 4ª Edição da Escola de Inverno de Farmácia, Porto, Portugal, 2019.
  7. Durães, Fernando; Barbosa, Filipa; Pinto, Madalena; Sousa, Emília. "Synthesis of aminated thioxanthones as agents to circumvent antimicrobial resistance". Paper presented in 4ª Edição da Escola de Inverno de Farmácia, Porto, Portugal, 2019.
  8. Barbosa, Filipa; Durães, Fernando; Pinto, Eugénia; Pinto, Madalena; Sousa, Emília. "Synthesis of thioxanthones as potential inhibitors of efflux pumps". Paper presented in 12.º Encontro de Investigação Jovem da Universidade do Porto, Porto, Portugal, 2019.
  9. Durães, Fernando; Barbosa, Filipa; Pinto, Eugénia; Pinto, Madalena; Sousa, Emília. "Halogen-exchange and amination of chlorinated thioxanthones". Paper presented in XXIV Encontro Luso-Galego de Química, Porto, Portugal, 2018.
  10. Durães, Fernando; Cravo, Sara; Palmeira, Andreia; Pinto, Madalena; Sousa, Emília. "New thioxanthone derivatives to circumvent drug resistance". Paper presented in Italian-Spanish-Portuguese Joint Meeting in Medicinal Chemistry (MedChemSicily2018), Palermo, Italy, 2018.
  11. Durães, Fernando; Gales, Luís; Cravo, Sara; Pinto, Madalena; Sousa, Emília. "Novel thiochromene quinazolines synthesized by copper-catalysed Ullmann type C – N coupling and unexpected dehydrative cyclization". Paper presented in 3ª Edição da Escola de Inverno de Farmácia, Porto, Portugal, 2018.
  12. Durães, Fernando; Gales, Luís; Cravo, Sara; Pinto, Madalena; Sousa, Emília. "Synthesis of novel thiochromene quinazolines by copper-catalyzed tandem Ullmann type C – N coupling and dehydrative cyclization". Paper presented in 12º Encontro Nacional de Química Orgânica/5º Encontro Nacional de Química Terapêutica (12ºENQO/5ºENQT), Coimbra, Portugal,, 2018.
  13. Lopes, Graciliana; Costa, Ana; Costa, Diana; Azevedo, Fábio; Durães, Fernando; Marques, José; Vilarinho, Joana; Gomes, Natacha. "Metabolome constituents, antimicrobial and antioxidant potential of the brown seaweed Laminaria ochroleuca". Paper presented in IJUP '14 – 7th Meeting of Young Researchers of the University of Porto, Porto, Portugal, 2014.
  14. Durães, Fernando; Cardoso, Érica; Cravo, Sara; Barbosa, João; Pedro, Madalena; Pinto, Madalena; Almeida, Ana Paula. "Cecropia catarinensis: A plant with antitumor potential". Paper presented in IJUP '13 – 6th Meeting of Young Researchers of the University of Porto, Porto, Portugal, 2013.
  15. Cardoso, Érica; Serdeiro, Michele; Durães, Fernando; Barbosa, João; Pedro, Madalena; Pinto, Madalena; Almeida, Ana Paula. "Antitumor potential of crude extract of Cecropia catarinensis for breast cancer and melanoma". Paper presented in 1st Luso-Brazilian Symposium of Sciences, Vassouras, Brazil, 2012.
  16. Faria, Ana Raquel; Durães, Fernando; Almeida, Ana Paula; Dethoup, Tida; Vasconcelos, Helena; Pinto, Madalena; Kijjoa, Anake. "Neosartorya spinosa a marine fungi isolated from the sponge Rhiabdermia sp.". Paper presented in IJUP '12 - 5th Meeting of Young Researchers of the University of Porto, 2012.
Journal article
  1. Diana I. S. P. Resende; Fernando Durães; Sidika Zubarioglu; Joana Freitas-Silva; Nikoletta Szemerédi; Madalena Pinto; Eugénia Pinto; et al. "Antibacterial Potential of Symmetrical Twin-Drug 3,6-Diaminoxanthones". Pharmaceuticals (2024): https://doi.org/10.3390/ph17020209.
    10.3390/ph17020209
  2. Francisca Carvalhal; Ana Cristina Magalhães; Rita Rebelo; Andreia Palmeira; Diana I. S. P. Resende; Fernando Durães; Miguel Maia; et al. "Evaluation of the Cytotoxic and Antiviral Effects of Small Molecules Selected by In Silico Studies as Inhibitors of SARS-CoV-2 Cell Entry". Molecules (2023): https://doi.org/10.3390/molecules28207204.
    10.3390/molecules28207204
  3. Mariana Almeida; Nikoletta Szemerédi; Fernando Durães; Solida Long; Diana I. S. P. Resende; Paulo Martins da Costa; Madalena M. M. Pinto; Gabriella Spengler; E Sousa. "Effect of Indole-Containing Pyrazino[2,1-b]quinazoline-3,6-diones in the Virulence of Resistant Bacteria". Antibiotics (2023): https://www.mdpi.com/2079-6382/12/5/922.
    10.3390/antibiotics12050922
  4. Miguel Maia; Fernando Durães; Diana I. S. P. Resende; Nikoletta Szemerédi; Luis Gales; Paulo Martins da Costa; Madalena M. M. Pinto; Gabriella Spengler; E Sousa. "Xanthene Derivatives Targeting Bacterial Efflux Pumps, Quorum-Sensing, and Biofilm Formation". Drugs and Drug Candidates (2022): https://www.mdpi.com/2813-2998/1/1/4.
    10.3390/ddc1010004
  5. Daniela Pereira; Fernando Durães; Nikoletta Szemerédi; Joana Freitas-da-Silva; Eugénia Pinto; Paulo Martins-da-Costa; Madalena Pinto; et al. "New Chalcone–Triazole Hybrids with Promising Antimicrobial Activity in Multidrug Resistance Strains". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232214291.
    10.3390/ijms232214291
  6. Ana Rita Neves; Fernando Durães; Joana Freitas-Silva; Nikoletta Szemerédi; Paulo Martins da Costa; Eugénia Pinto; Marta Correia-da-Silva; Gabriella Spengler; E Sousa. "Derivatives of Trimethoxybenzoic Acid and Gallic Acid as Potential Efflux Pump Inhibitors: In Silico and In Vitro Studies". International Journal of Molecular Sciences (2022): https://www.mdpi.com/1422-0067/23/22/14468.
    10.3390/ijms232214468
  7. Joana Filipa de Olas e Sousa Martins Cardoso; Joana Freitas-Silva; Fernando Durães; Diogo Teixeira Carvalho; Luis Gales; Madalena M. M. Pinto; E Sousa; Eugénia Pinto. "Antifungal Activity of a Library of Aminothioxanthones". Antibiotics (2022): https://www.mdpi.com/2079-6382/11/11/1488.
    10.3390/antibiotics11111488
  8. Ana Jesus; Fernando Durães; Nikoletta Szemerédi; Joana Freitas-Silva; Paulo Martins da Costa; Eugénia Pinto; Madalena M. M. Pinto; et al. "BDDE-Inspired Chalcone Derivatives to Fight Bacterial and Fungal Infections". Marine Drugs (2022): https://www.mdpi.com/1660-3397/20/5/315.
    10.3390/md20050315
  9. "New Diarylpentanoids and Chalcones as Potential Antimicrobial Adjuvants". Bioorganic & Medicinal Chemistry Letters (2022): 128743-128743. http://dx.doi.org/10.1016/j.bmcl.2022.128743.
    10.1016/j.bmcl.2022.128743
  10. Fernando Durães; Sara M. Cravo; Joana Freitas-Silva; Nikoletta Szemerédi; Paulo Martins da Costa; Eugénia Pinto; Maria Elizabeth Tiritan; et al. "Enantioselectivity of Chiral Derivatives of Xanthones in Virulence Effects of Resistant Bacteria". Pharmaceuticals (2021): https://www.mdpi.com/1424-8247/14/11/1141.
    10.3390/ph14111141
  11. Fernando Durães; Nikoletta Szemerédi; Decha Kumla; Madalena M. M. Pinto; Anake Kijjoa; Gabriella Spengler; E Sousa. "Metabolites from Marine-Derived Fungi as Potential Antimicrobial Adjuvants". Marine Drugs (2021): https://www.mdpi.com/1660-3397/19/9/475.
    10.3390/md19090475
  12. Fernando Durães; Andreia Palmeira; Bárbara Cruz; Joana Freitas-Silva; Nikoletta Szemerédi; Luís Gales; Paulo Martins da Costa; et al. "Antimicrobial Activity of a Library of Thioxanthones and Their Potential as Efflux Pump Inhibitors". Pharmaceuticals 14 6 (2021): 572-572. https://doi.org/10.3390/ph14060572.
    10.3390/ph14060572
  13. Fernando Durães; Diana I. S. P. Resende; Andreia Palmeira; Nikoletta Szemerédi; Madalena M. M. Pinto; Gabriella Spengler; Emília Sousa. "Xanthones Active against Multidrug Resistance and Virulence Mechanisms of Bacteria". Antibiotics 10 5 (2021): 600-600. https://doi.org/10.3390/antibiotics10050600.
    10.3390/antibiotics10050600
  14. Fernando Durães; Madalena M. M. Pinto; Pedro Novais; Isabel Amorim; Luis Gales; Cátia I. C. Esteves; samuel guieu; et al. "Tetracyclic Thioxanthene Derivatives: Studies on Fluorescence and Antitumor Activity". Molecules (2021): https://www.mdpi.com/1420-3049/26/11/3315.
    10.3390/molecules26113315
  15. Maia, Miguel; Resende, Diana I.S.P.; Durães, Fernando; Pinto, Madalena M.M.; Sousa, Emília. "Xanthenes in Medicinal Chemistry – Synthetic strategies and biological activities". European Journal of Medicinal Chemistry 210 (2021): 113085. http://dx.doi.org/10.1016/j.ejmech.2020.113085.
    10.1016/j.ejmech.2020.113085
  16. Ndongo, T.M.; Passos, M.L.C.; Durães, F.; Resende, D.I.S.P.; Pinto, M.; Sousa, E.; Saraiva, M.L.M.F.S.. "Microsequential injection analysis/lab-on-valve system for the automatic evaluation of acetylcholinesterase inhibitors". Archiv der Pharmazie (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85107786379&partnerID=MN8TOARS.
    10.1002/ardp.202100150
  17. Diana I. S. P. Resende; Fernando Durães; Miguel Maia; Emília Sousa; Madalena M. M. Pinto. "Recent advances in the synthesis of xanthones and azaxanthones". Organic Chemistry Frontiers (2020): https://doi.org/10.1039/D0QO00659A.
    10.1039/D0QO00659A
  18. Durães; Sousa. "Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines". Pharmaceuticals 12 2 (2019): 63-63. https://doi.org/10.3390/ph12020063.
    10.3390/ph12020063
  19. Durães, Fernando. "Old Drugs as New Treatments for Neurodegenerative Diseases". Pharmaceuticals (2018): http://www.mdpi.com/1424-8247/11/2/44.
    10.3390/ph11020044
  20. Duraes FAPM; Pinto MMM; de Sousa MESP. "Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators.". Current medicinal chemistry (2018): http://europepmc.org/abstract/med/29424299.
    10.2174/0929867325666180209142612
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/02/12 Marine bromophenol BDDE as a model for the synthesis of new chalcone derivatives with antibiotic synergic effects IJUP '20 - 5th Meeting of Young Researchers of the University of Porto
University of Porto (Porto, Portugal)
2019/11/26 Aminothioxanthonic Derivatives: Synthesis and Study of Antifungal Synergistic Effect SIFFUP - Research Symposium of the Faculty of Pharmacy of the University of Porto
Faculty of Pharmacy, University of Porto (Porto, Portugal)
2019/05/24 Design and synthesis of thioxanthones as potential bacterial efflux pump inhibitors 12th European Workshop in Drug Design
University of Siena (Siena, Italy)
2017/12/04 Models from the sea: synthesis of potential new antibacterial agents 2nd International Christmas Caparica Congress in Translational Chemistry - IC3TC-2017
(Lisboa, Portugal)
2017/06/27 Medicinal Chemistry Updates on Bacterial Efflux Pump Modulators Xth LQOF Summer Course, "Pharmaceutical Drugs: how to obtain, how do they work and why (a perspective in Pharmaceutical Medicinal Chemistry)"
(Porto, Portugal)
Distinctions

Award

2021 Best Presentation. 7th International Electronic Conference on Medicinal Chemistry
MDPI AG, Switzerland

Other distinction

2019 PhD Grant SFRH/BD/144681/2019
Fundação para a Ciência e a Tecnologia, Portugal