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Sandra Louzada Gomes Pereira (Sandra Louzada) completed the degree (BSc) in Biology and Geology (Education) in 2004 and the PhD in Molecular, Comparative and Technological Genetics in 2013 at University of Trás-os-Montes and Alto Douro (UTAD). Worked as Senior Research Assistant at the Cytogenetics Core Facility in Wellcome Sanger Institute (Cambridge, UK), where she collaborated with varied research groups resulting in high standard publications. Presently is a Junior Researcher (with a CEEC contract) at the CytoGenomics Lab, UTAD, and is an integrated member of Biosystems and Integrative Sciences Institute (BioISI). Specialized in molecular cytogenetics, the study of chromosomes, their structure and evolution, using fluorescent in situ hybridization (FISH). Previous research focused on karyotype restructuring during species evolution and cancer progression, focusing in the role of satellite DNA sequences in shaping the genomes landscape; and using FISH as a validation tool, in particular multicolour fiber-FISH (on single-molecule DNA fibers prepared by molecular combing) to visualise, resolve and validate complex genomic structural variants in human populations. Is currently dedicated to the study of Robertsonian translocations using long-read sequencing technologies, and the characterisation of the satellite DNA sequences (centromeric and pericentromeric) and the functional significance of non-coding satellite RNAs using genomic and cellular biology methodologies .
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Identification

Personal identification

Full name
Sandra Louzada Gomes Pereira

Citation names

  • Pereira, Sandra
  • Sandra Louzada

Author identifiers

Ciência ID
D911-F4B8-27D8
ORCID iD
0000-0003-2245-8453
Scopus Author Id
24436243700

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2013
Concluded
 Molecular, Comparative and Tecnological Genetics (Doutoramento)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
"Karyotype restructuring in Rodentia: from evolution to cancer" (THESIS/DISSERTATION)
 19
2005
Concluded
 Post-graduation course in Molecular, Comparative and Tecnological Genetics (Curso de Especialização Tecnológica)
Universidade de Trás-os-Montes e Alto Douro, Portugal
 17
2004
Concluded
 Biology and Geology (teaching) (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Monografia de Biologia e Geologia" (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2019/06/01 - Current Researcher (Research) Universidade de Trás-os-Montes e Alto Douro, Portugal
Universidade de Trás-os-Montes e Alto Douro, Portugal
2012/03/19 - 2019/05/31 Research Assistant (Research) Wellcome Sanger Institute, United Kingdom

Teaching in Higher Education

Category
Host institution 		Employer
2008 - 2009 Assistant (University Teacher) Universidade de Trás-os-Montes e Alto Douro, Portugal
2004/09 - 2005/02 Assistant (University Teacher) Universidade de Trás-os-Montes e Alto Douro, Portugal

Other Careers

Category
Host institution 		Employer
2003/09/01 - 2004 Professor do ensino básico e secundário (Professor do ensino básico e secundário) Escola Secundária Fernão De Magalhães, Portugal

Others

Category
Host institution 		Employer
2010/06/01 - 2011/08/01 Research fellow - PTDC/MAR/66143/2006 designado “Construção de um mapa físico para ostras usando a técnica fluorescent in situ hybridization”. Universidade de Trás-os-Montes e Alto Douro, Portugal
Projects

Grant

Designation Funders
2022/01/16 - 2023/10/16 Resolving Robertsonian Translocations in humans: validation of an experimental strategy to unlock Robertsonian centromeres
EXPL/BIA-OUT/1028/2021
Principal investigator
Universidade de Trás-os-Montes e Alto Douro, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2010 - 2011 Construction of a physical map for oysters using the fluorescent in situ hybridization technique
PTDC/MAR/66143/2006
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2005 - 2008 Comparative Chromosome Maps for Rodent Species. Rodent Chromosome Evolution, Chromosome Bar – codes Resources and Genomic Functional Aspects
POCI/BIA-BCM/58541/2004
Other
Universidade de Trás-os-Montes Centro de Estudos Transdisciplinares para o Desenvolvimento, Portugal
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2019/06/01 - 2025/05/31 Unlocking Robertsonian centromeres with Nanopore sequencing: a mechanistic insight
CEECIND/01825/2017/CP1418/CT0003
10.54499/CEECIND/01825/2017/CP1418/CT0003
Other
Universidade de Trás-os-Montes e Alto Douro, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Louzada, Sandra; Yang, Fengtang. "High-Resolution FISH Analysis Using DNA Fibers Generated by Molecular Combing". In Cancer Cytogenetics and Cytogenomics, 185-203. Springer US, 2024.
    10.1007/978-1-0716-3946-7_10
  2. Sandra Louzada. "Fluorescence In Situ Hybridization onto DNA Fibres Generated Using Molecular Combing". 2017.
    10.1007/978-3-662-52959-1
Conference abstract
  1. Sandra Louzada. "Comparative Analysis of HSAT1 Satellite DNA in Primates". Naples, 2024.
    Published
  2. Mariana Lopes; Sandra Louzada; Daniela Ferreira; Vukosava Torres; Margarida Gama-Carvalho; Raquel Chaves. "Overexpressed human satellite 1A noncoding RNA is a central player in microtubule dynamics". Heidelberg, 2023.
    Published
  3. Erica Rego; Sandra Louzada; Raquel Chaves; Daniela Ferreira. "FA-SAT ncRNA influence in anti-mitotic drug response in human cancer cell lines". Vila Real, 2023.
    Published
  4. Tatiana Afonso; Sandra Louzada; Raquel Chaves; Daniela Ferreira. "FA-SAT ncRNA functional profile in different passages of a feline mammary cancer cell line.". Vila Real, 2023.
    Published
  5. Carlos Vila-Verde; Mariana Lopes; Raquel Chaves; Sandra Louzada. "Genomic analysis of the human HSAT1 satellite DNA sequence in primates". Vila Real, 2023.
    Published
  6. Mariana Lopes; Sandra Louzada; Gabriela Verissimo; Margarida Gama-Carvalho; Raquel Chaves. "Seeing is believing: transcription profiling of Human Satellite 1?". Paper presented in III International Meeting of the Portuguese Society of Genetics, Evora, 2022.
    Published
  7. Marisa Fonseca-Carvalho; Daniela Ferreira; Diogo Lucas; Gabriela Verissimo; Filomena Adega; Pereira, Sandra. "Preliminary data about FA-SAT ncRNA function in Mitosis". Evora, 2022.
    Published
  8. Veríssimo, Gabriela; Lopes, Mariana; Fonseca-Carvalho, Marisa; Daniela Ferreira; Pereira, Sandra; Raquel Chaves. "Can HSAT1 colocalize with hotspots for chromosomal breaks?". Evora, 2022.
    Published
  9. Lopes, Mariana; Sandra Louzada; Ferreira, Daniela; Gabriela Verissímo; Gama-Carvalho, Margarida; Chaves, Raquel. "Seeing is believing: transcription profiling of Human Satellite 1". Paper presented in III International Meeting of the Portuguese Society of Genetics, Évora, 2022.
    Published
  10. Fonseca-Carvalho, Marisa; Daniela Ferreira; Mariana Lopes; Diogo Lucas; Gabriela Verissimo; Filomena Adega; Sandra Louzada; Chaves, Raquel. "FA-SAT molecular and cellular characterization in human cancer cells.". Vila Real, 2022.
    Published
  11. Gabriela Veríssimo; Lopes, Mariana; Marisa Fonseca-Carvalho; Daniela Ferreira; Sandra Louzada; Chaves, Raquel. "Molecular and cytogenetic analysis of satellite DNA I sequences in different human cell lines". Vila Real, 2022.
  12. Mariana Lopes; Sandra Louzada; Ferreira, Daniela; Ana Escudeiro; Filomena Adega; Margarida Gama-Carvalho; Raquel Chaves. "Describing AT-rich Human Satellite I". Paper presented in II International Meeting of the Portuguese Society of Genetics, Vila Real, 2021.
    Published
  13. Sandra Louzada. "Characterisation of complex genomic structure and variation by high resolution fibre-FISH: an overview". 2019.
    10.1186/s13039-019-0439-z
  14. Sandra Louzada; Algady, Walid; Brajer, Paulina; Yang, Fengtang; EJ Hollox. "Characterization of structural variation of the human glycophorin locus using multicolour fibre-FISH". Salzburg, 2019.
    Published
  15. Sandra Louzada; Nzar A. Shwan; Beiyuan Fu; John Armour; Fengtang Yang. "Defining haplotypes of complex structural variation using multicolour fibre FISH amylase CNV study". Paper presented in 11th European Cytogenetics Conference, Florence, 2017.
    Published • 10.1186/s13039-017-0319-3
  16. Fengtang Yang; Sandra Louzada; Beiyuan Fu; Ruby Banerjee; Chris Tyler-Smith. "Direct visualization of complex structural and copy number variation by molecular combing and multicolor-FISH". Paper presented in 10th European Cytogenetics Conference, Strasbourg, 2015.
    Published • https://doi.org/10.1007/s10577-015-9476-6.
  17. Sandra Louzada; Maria Filomena Lopes Adega; Raquel Maria dos Santos Chaves. "Molecular cytogenetic characterization of a cell clone from a rat fibrosarcoma cell line". Paper presented in 19th International Colloquium on animal cytogenetics and gene mapping, 2010.
    Published • https://doi.org/10.1007/s10577-010-9145-8
  18. Ana Vieira-da-Silva; Sandra Louzada; Maria Filomena Lopes Adega; Henrique Guedes-Pinto; Raquel Maria dos Santos Chaves. "An orthologous satellite DNA family between Muridae and Cricetidae (Rodentia)". Paper presented in 19th International Colloquium on animal cytogenetics and gene mapping, 2010.
    https://doi.org/10.1007/s10577-010-9145-8
  19. Ana Vieira-da-Silva; Sandra Louzada; Maria Filomena Lopes Adega; Henrique Guedes-Pinto; Raquel Maria dos Santos Chaves. "Comparative analysis of two Cricetus cricetus chromosomes with Mus musculus and Rattus norvegicus using chromosome painting.". Paper presented in 7th European Cytogenetics Conference, Stokholm, 2009.
    Published • https://doi.org/10.1007/s10577-009-9042-1
  20. Sandra Louzada; Ana Vieira-da-Silva; Maria Filomena Lopes Adega; Henrique Guedes-Pinto; Raquel Maria dos Santos Chaves. "Mouse and rat genomes uncover the chromosome restructuring in Peromyscus eremicus (Cricetidae, Rodentia)-Chromosomes 1 and 5 in focus". Paper presented in 7th European Cytogenetics Conference, Stockolm, 2009.
    Published • https://doi.org/10.1007/s10577-009-9042-1
  21. Ana Vieira-da-Silva; Sandra Louzada; Maria Filomena Lopes Adega; S Kubickova; Henrique Guedes-Pinto; Jiri Rubes; Raquel Maria dos Santos Chaves. "X chromosome patchwork in the rodents Cricetus cricetus, Peromyscus eremicus (Cricetidae) and Praomys tullbergi (Muridae).". Paper presented in 16th International Chromosome Conference (16th ICC), Amesterdam, 2007.
    Published
  22. Sandra Louzada; Ana Vieira-da-Silva; Svatva Kubickova; Maria Filomena Lopes Adega; Henrique Guedes-Pinto; Raquel Maria dos Santos Chaves. "Cricetus cricetus and Peromyscus eremicus (Rodentia, Cricetidae) share common repetitive DNA sequences". Paper presented in 16th International Chromosome Conference, Amesterdam, 2007.
    Published • https://doi.org/10.1007/s10577-007-1912-9
Conference poster
  1. Carlos Vila-Verde; Mariana Lopes; Daniel Eleutério; Raquel Chaves; Sandra Louzada. Corresponding author: Raquel Chaves. "Comparative analysis of HSat1 satellite DNA in primates". 2024.
  2. Lucas, diogo; Lopes, Mariana; Ferreira, Daniela; Sandra Louzada; Chaves, Raquel. "Deciphering the Role of FA-SAT ncRNA in Cellular Apoptosis: Insights from Functional Studies in p53 Wild-Type and Null Cell Lines". Paper presented in IV International Meeting of the Portuguese Society of Genetics, 2023.
  3. Marisa Fonseca-Carvalho; Ferreira, Daniela; Lopes, Mariana; Lucas, Diogo; Gabriela Verissímo; ´Filomena Adega; Sandra Louzada; Chaves, Raquel. "Preliminary data about FA-SAT ncRNA function in Mitosis". Paper presented in III International Meeting of the Portuguese Society of Genetics, 2022.
  4. Lopes, Mariana; Escudeiro, Ana; Adega, Filomena; Sandra Louzada; Dias, Ricardo; Gama-Carvalho, Margarida; Chaves, Raquel. "Filling the gaps: disclosure of the human centromere in Robertsonian translocated chromosomes using Nanopore sequencing". Paper presented in GenomePT symposium, 2019.
Journal article
  1. Mariana Lopes; Sandra Louzada; Margarida Gama-Carvalho; Raquel Chaves. "Pericentromeric satellite RNAs as flexible protein partners in the regulation of nuclear structure". WIREs RNA (2024): https://doi.org/10.1002/wrna.1868.
    10.1002/wrna.1868
  2. Fonseca-Carvalho, Marisa; Veríssimo, Gabriela; Lopes, Mariana; Ferreira, Daniela; Louzada, Sandra; Chaves, Raquel. "Answering the Cell Stress Call: Satellite Non-Coding Transcription as a Response Mechanism". Biomolecules 14 1 (2024): 124. http://dx.doi.org/10.3390/biom14010124.
    10.3390/biom14010124
  3. Lopes, Mariana; Louzada, Sandra; Ferreira, Daniela; Veríssimo, Gabriela; Eleutério, Daniel; Gama-Carvalho, Margarida; Chaves, Raquel. "Human Satellite 1A analysis provides evidence of pericentromeric transcription". BMC Biology 21 1 (2023): http://dx.doi.org/10.1186/s12915-023-01521-5.
    10.1186/s12915-023-01521-5
  4. Hollox, Edward J.; Louzada, Sandra. "Genetic variation of glycophorins and infectious disease". Immunogenetics 75 3 (2022): 201-206. http://dx.doi.org/10.1007/s00251-022-01280-7.
    10.1007/s00251-022-01280-7
  5. Paredes-Redondo, Amaia; Harley, Peter; Maniati, Eleni; Ryan, David; Louzada, Sandra; Meng, Jinhong; Kowala, Anna; et al. "Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections". Science Advances 7 37 (2021): http://dx.doi.org/10.1126/sciadv.abi8787.
    10.1126/sciadv.abi8787
  6. Lopes, Mariana; Louzada, Sandra; Gama-Carvalho, Margarida; Chaves, Raquel. "Genomic Tackling of Human Satellite DNA: Breaking Barriers through Time". International Journal of Molecular Sciences 22 9 (2021): 4707. http://dx.doi.org/10.3390/ijms22094707.
    10.3390/ijms22094707
  7. Louzada, Sandra; Algady, Walid; Weyell, Eleanor; Zuccherato, Luciana W.; Brajer, Paulina; Almalki, Faisal; Scliar, Marilia O.; et al. "Structural variation of the malaria-associated human glycophorin A-B-E region". BMC Genomics 21 1 (2020): http://dx.doi.org/10.1186/s12864-020-06849-8.
    Published • 10.1186/s12864-020-06849-8
  8. Louzada, Sandra; Lopes, Mariana; Ferreira, Daniela; Adega, Filomena; Escudeiro, Ana; Gama-Carvalho, Margarida; Chaves, Raquel. "Decoding the Role of Satellite DNA in Genome Architecture and Plasticity—An Evolutionary and Clinical Affair". Genes 11 1 (2020): 72. http://dx.doi.org/10.3390/genes11010072.
    Published • 10.3390/genes11010072
  9. Kim, Jihee; Lana, Beatrice; Torelli, Silvia; Ryan, David; Catapano, Francesco; Ala, Pierpaolo; Luft, Christin; et al. "A new patient-derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of a-dystroglycan". EMBO reports 20 11 (2019): http://dx.doi.org/10.15252/embr.201947967.
    Published • 10.15252/embr.201947967
  10. Shi, Wentao; Massaia, Andrea; Louzada, Sandra; Handsaker, Juliet; Chow, William; McCarthy, Shane; Collins, Joanna; et al. "Birth, expansion, and death of VCY-containing palindromes on the human Y chromosome". Genome Biology 20 1 (2019): http://dx.doi.org/10.1186/s13059-019-1816-y.
    Published • 10.1186/s13059-019-1816-y
  11. Sandra Louzada; Walid Algady; Eleanor Weyell; Luciana W. Zuccherato; Paulina Brajer; Faisal Almalki; Marilia O Scliar; et al. "Structural variation of the malaria-associated human glycophorin A-B-E region". BioRxiv (2019):
    Published • https://doi.org/10.1101/722371
  12. Wentao Shi; Sandra Louzada; Marina Grigorova; Andrea Massaia; Elena Arciero; Laura Kibena; Xiangyu Jack Ge; et al. "Evolutionary and functional analysis of RBMY1 gene copy number variation on the human Y chromosome". Human Molecular Genetics 28 (2019): 2785-2798. http://europepmc.org/articles/PMC6687947.
    Open access • 10.1093/hmg/ddz101
  13. Mamunur Rashid; Michiel P J van der Horst; Thomas Mentzel; Francesca Butera; Ingrid Ferreira; Alena Pance; Arno Rütten; et al. "ALPK1 hotspot mutation as a driver of human spiradenoma and spiradenocarcinoma". Nature Communications 10 (2019): http://europepmc.org/articles/PMC6525246.
    Open access • 10.1038/s41467-019-09979-0
  14. Emanuel Gonçalves; Fiona M. Behan; Sandra Louzada; Damien Arnol; Euan A. Stronach; Fengtang Yang; Kosuke Yusa; et al. "Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects". Genome Biology 20 (2019): http://europepmc.org/articles/PMC6362594.
    Open access • 10.1186/s13059-019-1637-z
  15. Algady, W; Louzada, S; Carpenter, D; Brajer, P; Färnert, A; Rooth, I; Ngasala, B; et al. "The Malaria-Protective Human Glycophorin Structural Variant DUP4 Shows Somatic Mosaicism and Association with Hemoglobin Levels". American Journal of Human Genetics 103 (2018): 769-776. http://europepmc.org/articles/PMC6218809.
    Open access • 10.1016/j.ajhg.2018.10.008
  16. Sebastian Mueller; Thomas Engleitner; Roman Maresch; Magdalena Zukowska; Sebastian Lange; Thorsten Kaltenbacher; Björn Konukiewitz; et al. "Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes". Nature 554 (2018): 62-68. http://europepmc.org/articles/PMC6097607.
    Open access • 10.1038/nature25459
  17. Garaycoechea, J.I.; Crossan, G.P.; Langevin, F.; Mulderrig, L.; Louzada, S.; Yang, F.; Guilbaud, G.; et al. "Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells". Nature 553 7687 (2018): 171-177. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040462100&partnerID=MN8TOARS.
    10.1038/nature25154
  18. Shi, W.; Massaia, A.; Louzada, S.; Banerjee, R.; Hallast, P.; Chen, Y.; Bergström, A.; et al. "Copy number variation arising from gene conversion on the human Y chromosome". Human Genetics 137 1 (2018): 73-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-85037658961&partnerID=MN8TOARS.
    10.1007/s00439-017-1857-9
  19. Shwan, N.A.A.; Louzada, S.; Yang, F.; Armour, J.A.L.. "Recurrent Rearrangements of Human Amylase Genes Create Multiple Independent CNV Series". Human Mutation 38 5 (2017): 532-539. http://www.scopus.com/inward/record.url?eid=2-s2.0-85012067092&partnerID=MN8TOARS.
    10.1002/humu.23182
  20. Lee, J.-K.; Louzada, S.; An, Y.; Kim, S.Y.; Kim, S.; Youk, J.; Park, S.; et al. "Complex chromosomal rearrangements by single catastrophic pathogenesis in NUT midline carcinoma". Annals of Oncology 28 4 (2017): 890-897. http://www.scopus.com/inward/record.url?eid=2-s2.0-85019068452&partnerID=MN8TOARS.
    10.1093/annonc/mdw686
  21. Maresch, R.; Mueller, S.; Veltkamp, C.; Öllinger, R.; Friedrich, M.; Heid, I.; Steiger, K.; et al. "Multiplexed pancreatic genome engineering and cancer induction by transfection-based CRISPR/Cas9 delivery in mice". Nature Communications 7 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84959295529&partnerID=MN8TOARS.
    10.1038/ncomms10770
  22. Poznik, G.D.; Xue, Y.; Mendez, F.L.; Willems, T.F.; Massaia, A.; Wilson Sayres, M.A.; Ayub, Q.; et al. "Punctuated bursts in human male demography inferred from 1,244 worldwide Y-chromosome sequences". Nature Genetics 48 6 (2016): 593-599. http://www.scopus.com/inward/record.url?eid=2-s2.0-84964284907&partnerID=MN8TOARS.
    10.1038/ng.3559
  23. Skinner, B.M.; Sargent, C.A.; Churcher, C.; Hunt, T.; Herrero, J.; Loveland, J.E.; Dunn, M.; et al. "The pig X and y Chromosomes: Structure, sequence, and evolution". Genome Research 26 1 (2016): 130-139. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956620072&partnerID=MN8TOARS.
    10.1101/gr.188839.114
  24. Vieira-Da-Silva, A.; Louzada, S.; Adega, F.; Chaves, R.. "A High-Resolution Comparative Chromosome Map of Cricetus cricetus and Peromyscus eremicus Reveals the Involvement of Constitutive Heterochromatin in Breakpoint Regions". Cytogenetic and Genome Research 145 1 (2015): 59-67. http://www.scopus.com/inward/record.url?eid=2-s2.0-84931956587&partnerID=MN8TOARS.
    10.1159/000381840
  25. Skinner, B.M.; Lachani, K.; Sargent, C.A.; Yang, F.; Ellis, P.; Hunt, T.; Fu, B.; et al. "Expansion of the HSFY gene family in pig lineages : HSFY expansion in suids". BMC genomics 16 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84938999584&partnerID=MN8TOARS.
    10.1186/s12864-015-1650-x
  26. Louzada, S.; Vieira-da-Silva, A.; Mendes-da-Silva, A.; Kubickova, S.; Rubes, J.; Adega, F.; Chaves, R.. "A novel satellite DNA sequence in the Peromyscus genome (PMSat): Evolution via copy number fluctuation". Molecular Phylogenetics and Evolution 92 (2015): 193-203. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938076398&partnerID=MN8TOARS.
    10.1016/j.ympev.2015.06.008
  27. Polley, S.; Louzada, S.; Forni, D.; Sironi, M.; Balaskas, T.; Hains, D.S.; Yang, F.; Hollox, E.J.. "Evolution of the rapidly mutating human salivary agglutinin gene (DMBT1) and population subsistence strategy". Proceedings of the National Academy of Sciences of the United States of America 112 16 (2015): 5105-5110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928722450&partnerID=MN8TOARS.
    10.1073/pnas.1416531112
  28. Auton, A.; Abecasis, G.R.; Altshuler, D.M.; Durbin, R.M.; Bentley, D.R.; Chakravarti, A.; Clark, A.G.; et al. "A global reference for human genetic variation". Nature 526 7571 (2015): 68-74. http://www.scopus.com/inward/record.url?eid=2-s2.0-84943171338&partnerID=MN8TOARS.
    10.1038/nature15393
  29. Ding, Z.; Ni, Y.; Timmer, S.W.; Lee, B.K.; Battenhouse, A.; Louzada, S.; Yang, F.; et al. "Correction: Quantitative Genetics of CTCF Binding Reveal Local Sequence Effects and Different Modes of X-Chromosome Association (PLoS Genet, 11, 4, (2015))". PLoS Genetics 11 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84955477148&partnerID=MN8TOARS.
    10.1371/journal.pgen.1005177
  30. Ding, Z.; Ni, Y.; Timmer, S.W.; Lee, B.-K.; Battenhouse, A.; Louzada, S.; Yang, F.; et al. "Quantitative Genetics of CTCF Binding Reveal Local Sequence Effects and Different Modes of X-Chromosome Association". PLoS Genetics 10 11 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84912078506&partnerID=MN8TOARS.
    10.1371/journal.pgen.1004798
  31. Louzada, S.; Adega, F.; Chaves, R.. "Defining the sister rat mammary tumor cell lines HH-16 cl.2/1 and HH-16.cl.4 as an In Vitro cell model for Erbb2". PLoS ONE 7 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855656021&partnerID=MN8TOARS.
    10.1371/journal.pone.0029923
  32. Chaves, R.; Louzada, S.; Meles, S.; Wienberg, J.; Adega, F.. "Praomys tullbergi (Muridae, Rodentia) genome architecture decoded by comparative chromosome painting with Mus and Rattus". Chromosome Research 20 6 (2012): 673-683. http://www.scopus.com/inward/record.url?eid=2-s2.0-84868191827&partnerID=MN8TOARS.
    10.1007/s10577-012-9304-1
  33. Louzada, S.; Paço, A.; Kubickova, S.; Adega, F.; Guedes-Pinto, H.; Rubes, J.; Chaves, R.. "Different evolutionary trails in the related genomes Cricetus cricetus and Peromyscus eremicus (Rodentia, Cricetidae) uncovered by orthologous satellite DNA repositioning". Micron 39 8 (2008): 1149-1155. http://www.scopus.com/inward/record.url?eid=2-s2.0-52049092978&partnerID=MN8TOARS.
    10.1016/j.micron.2008.05.008
Online resource
  1. Sandra Louzada; Vieira-da-Silva, A.; Kubickova, S.; Adega, F.; Guedes-Pinto, H.; Raquel Maria dos Santos Chaves. Peromyscus eremicus clone cgbPER_1 satellite sequence, GenBank: GQ902036.1. 2009. https://www.ncbi.nlm.nih.gov/nuccore/GQ902036.
Preprint
  1. Blumer, L. M.; Burskaia, V.; Artiushin, I.; Saha, J.; Camacho Garcia, J.; Elkin, J.; Fischer, B.; et al. "Introgression dynamics of sex-linked chromosomal inversions shape the Malawi cichlid adaptive radiation". 2024. http://dx.doi.org/10.1101/2024.07.28.605452.
    10.1101/2024.07.28.605452
  2. Mariana Lopes; Sandra Louzada; Daniela Ferreira; Gabriela Veríssimo; Daniel Eleutério; Margarida Gama-Carvalho; Raquel Chaves. "Human Satellite 1 (HSAT1) analysis provides novel evidence of pericentromeric transcription". 2022. https://doi.org/10.1101/2022.08.11.503625.
    10.1101/2022.08.11.503625
Thesis / Dissertation
  1. Sandra Louzada. "Karyotype restructuring in Rodentia: from evolution to cancer". PhD, Universidade de Trás-os-Montes Centro de Estudos Transdisciplinares para o Desenvolvimento, 2013. http://hdl.handle.net/10348/5303.

Other

Other output
  1. Guest Editor for Biomolules special Issue 'The Evolution and Function of Repetitive DNA'. 2024. Sandra Louzada; Raquel Maria dos Santos Chaves. https://www.mdpi.com/journal/biomolecules/special_issues/R0TKA9J5AG.
  2. Participation in the podcast '90 Segundos de Ciência'. Antena 1 / RTP play. 2024. Louzada. https://www.rtp.pt/play/p2936/e761550/90-segundos-ciencia.
  3. BioISI Digest | Human Satellite 1A analysis provides evidence of pericentromeric transcription. 2023. Sandra Louzada. https://bioisi.pt/news/59.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2018 Contribution of fluorescence in situ hybridization to the study of genomic rearrangements and structural variation X Jornadas de Genética e Biotecnologia
(Vila Real, Portugal)
2017/07 Defining haplotypes of complex structural variation using multicolor fibre-FISH: amylase CNV study 11thEuropean Cytogenetics Conference
European Cytogenetics Association (Florence, Italy)
2015/07 Direct visualization of complex structural and copy number variation by molecular combing and multicolor-FISH 10th European Cytogenetics Conference
European Cytogenetics Association (Strasbourg, France)
2009/04 Preliminary study of Peromyscus eremicus (Rodentia, Cricetidae) chromosome reorganization revealed by mouse and rat paint probes XXXIV Jornadas Portuguesas de Genética
Sociedade Portuguesa de Genética (Lisbon, Portugal)
2008/08 The freewill of evolution in the restructuring of Rodentia genomes 16th ICC
(Amesterdam, Netherlands)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/12/01 - Current Satellite DNA sequences: Genetic determinants of chromosome rearrangements? (2024.04110.BD)
Supervisor
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2024/10/01 - Current A Genomic and Transcriptional Analysis of Human Satellite 1B in Primates
Supervisor
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2023/10/01 - Current Influence of HSat1A on cell proliferation and tumour progression
Supervisor
 Biotecnologia para as Ciências da Saúde – BCS (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2024/02/01 - 2024/07/04 Cariotipagem de uma linha celular tumoral aplicando a metodologia de M-FISH
Supervisor
 Genética e Biotecnologia (Other)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2024/01/02 - 2024/07/04 An¿lise da din¿mica molec¿lar do comple¿o ribon¿cleopro¿eico FA-SA¿ ncRNA/PKM2
Co-supervisor
 Genetica e Biotecnologia (Other)
Unidade Local de Saúde de Trás-os-Montes e Alto Douro, Portugal
2024/01/02 - 2024/07/04 Validação dos interatores com HSat1A por Western-Blot
Supervisor
 Genética e Biotecnologia (Other)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2020/02 - 2024/06/03 The role of HSat1A noncoding RNA in cancer-related phenotypes (SFRH/BD/147488/2019)
Co-supervisor
Universidade de Trás-os-Montes Centro de Estudos Transdisciplinares para o Desenvolvimento, Portugal
2023/03/02 - 2023/07 Perfil de transcrição do HSat1A em células tumorais expostas a agentes quimioterapêuticos
Supervisor
 Genética e Biotecnologia (Other)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2023/03/02 - 2023/07 Distribuição de transcritos HSat1A ao longo do ciclo celular
Co-supervisor
 Genética e Biotecnologia (Other)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2023/03/02 - 2023/07 Potencial do silenciamento do FA-SAT ncRNA como sensibilizador de células resistentes ao Taxol
Co-supervisor
 Genética e Biotecnologia (Other)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2023/03/02 - 2023/07 Análise funcional de uma sequência de DNA satélite em diferentes passagens de uma linha celular de tumor mamário de gata
Co-supervisor
 Genética e Biotecnologia (Other)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2021/09/01 - 2023/06/01 Characterization of satellite DNA sequences associated with human Robertsonian translocations
Supervisor
 Biotecnologia para as Ciências da Saúde (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2022/03/02 - 2022/07/26 Análise genómica da sequência de DNA satélite humano HSAT1 em primatas
Co-supervisor
 Genética e Biotecnologia (Other)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2022/03/02 - 2022/07/14 Mapeamento de clones de BAC para o estudo de translocações Robertsonianas
Supervisor
 Genética e Biotecnologia (Other)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2009 - 2010 Caracterização citogenética de um clone de uma linha celular tumoral de Rattus norvegicus
Supervisor
 Genética e Biotecnologia (Degree)
Universidade de Trás-os-Montes e Alto Douro, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/03/22 - 2023/03/22 The Power of Microscopy Workshop (2023/03/22 - 2023/03/22)
Workshop (Co-organisor)
 Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/01/17 - 2023/01/19 Ion Torrent Instrument Training
Other
 Ion Torrent Instrument training

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/07/04 Caracterização clínica e genómica dos carcinomas papilares da tiroide relacionados com as enzimas APOBEC
(Thesis) Main arguer
 Ricardo Campos (Other)
Unidade Local de Saúde de Trás-os-Montes e Alto Douro, Portugal
2024/07/04 Identificação de marcadores moleculares de inibição combinada de EGFR e STAT3 e a sua relação com subtipos de cancro de próstata
(Thesis) Main arguer
 Carolina Vitória Nunes Teixeira (Other)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2023/12/21 Therapeutic opportunities of anti-fascin compounds against histological variants of lymphoma
(Thesis) Main arguer
 DANIEL AFONSO CHEDAS (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal
2022/07/28 Hybrid nanosystems for cancer therapy
(Thesis) Main arguer
 Claúdia Patrícia Vilela Teixeira (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2022/06/03 Disclosing the FA-SAT ncRNA role in cancer cells
(Thesis) Main arguer
 Diogo Lucas (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2021/07/15 Analysis of the involvement of transposable elements in spinal muscular atrophy
(Thesis) Main arguer
 Catarina Filipa Eira Velha Cunha (Master)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2019/11 Unlocking Robertsonian translocated chromosomes in its repetitive DNA content to tackle genomic and mechanistic issues
(Thesis) Main arguer
 Mariana Lopes Faria (Master)
Universidade de Trás-os-Montes e Alto Douro, Portugal

Mentoring / Tutoring

Topic Student name
2015/10/01 - 2016/02/29 A detailed comparative Y-chromosome map between the gibbon Nomascus leucogenys and Humans. Sara Inácio Felício
2015/10 - 2016/02 A Y-chromosome map between the gibbon Nomascus leucogenys and Humans: evolutionary inferences and biomedical applications. Liliana Sofia Meireles da Costa
Distinctions

Award

2024 Best Poster Prize -25th International Colloquium on Animal Cytogenetics and Genomics

Other distinction

2005 Prémio Eng. António de Almeida
Fundação Engenheiro António de Almeida, Portugal