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Isabel Maria Theriaga Mendes Varanda Gonçalves, is a professor of Molecular Biology at the Faculdade de Ciências da Saúde of the Universidade da Beira Interior and member of the Health Sciences Research Center (CICS-UBI). In 1989 she obtained a Degree in Applied Chemistry-Biotechnology, Universidade NOVA de Lisboa-Faculdade de Ciências e Tecnologia and completed her PhD in Biology-Molecular Biology in 2000, Universidade Nova de Lisboa-Faculty of Sciences and Technology. She has published 47 articles in international peer-reviewed journals and 2 book chapters.
Identification

Personal identification

Full name
Isabel Maria Theriaga Mendes Varanda Gonçalves

Citation names

  • Gonçalves, Isabel
  • Gonçalves I

Author identifiers

Ciência ID
D916-0E13-ECB8
ORCID iD
0000-0002-4384-8197

Email addresses

  • igoncalves@fcsaude.ubi.pt (Professional)

Telephones

Telephone
  • (+351) 275329044 (Professional)

Addresses

  • Faculdade de Ciências da Saúde-Universidade da Beira Interior. Av.Infante D.Henrique, 6200-506, Covilhã, Covilhã, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Health Sciences
Education
Degree Classification
2000
Concluded
 Biologia (Doutoramento)
Major in Especialidade: Biologia Molecular
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Regulação da Expressão dos Genes da y Globina Humana" (THESIS/DISSERTATION)
1984 - 1989
Concluded
 Química Aplicada (Licenciatura)
Major in Biotecnologia
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"N/A" (THESIS/DISSERTATION)
 16/20
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2004/01/01 - Current Assistant Professor (University Teacher) Universidade da Beira Interior, Portugal
2000/05/19 - 2001/05/04 Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
1994/04/08 - 2000/05/18 Assistant (University Teacher) Universidade Nova de Lisboa, Portugal
1990/02/22 - 1994/04/07 Trainee Assistant (University Teacher) Universidade Nova de Lisboa, Portugal

Others

Category
Host institution 		Employer
2004/01/01 - 2007/01/01 Post-doctoral fellow (FCT, SFRH/BPD/19337/2004) Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Projects

Contract

Designation Funders
2018/07/01 - 2021/06/30 Suportes modificados com Liquidos Iónicos para a Purificação de pré-miRNAs envolvidos na doença de Alzheimer
PTDC/BII-BBF/29496/2017
Universidade da Beira Interior, Portugal

Universidade de Aveiro, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020 - 2021 Efeitos da Prolactina no transcriptoma do Plexo Coróide de rato
Project Centro-01-0145-FEDER-000019—C4—Centro de Competências em Cloud Computing
Researcher
Universidade da Beira Interior, Portugal
 European Regional Development Fund
Ongoing
2020 - 2021 Efeito da ativação de recetores de paladar regulados por hormonas no plexo coróide
Project Centro-01-0145-FEDER-000019—C4—Centro de Competências em Cloud Computing
Principal investigator
Universidade da Beira Interior, Portugal
Ongoing
2017/04 - 2020/03 Interdisciplinary Challanges On Neurodegeneration (ICON)
CENTRO-01-0145-FEDER-000013
 Horizon 2020
2013 - 2015 Hormonal and Inflammatory basis of age-related diseases
GRANT_NUMBER: CENTRO-07-ST24-FEDER-002015
 Comissão de Coordenação e Desenvolvimento Regional do Centro, Programa Operacional Regional do Centro 2007-2013 QREN
2012 - 2014 Microarray based identification of estrogen and androgen responsive genes in rat choroid plexus
PROJECT PTDC/SAU-NMC/114800/2009
 Ministério da Ciência Tecnologia e Ensino Superior
2010 - 2013 Molecular genetics and functional genomics of pituitary hormone deficiencies
PTDC/SAU-GMG/098419/2008
 Fundação para a Ciência e Tecnologia
Outputs

Publications

Book chapter
  1. Gonçalves, Isabel; Quintela, Telma; Duarte, Ana Catarina; Hubbard, Peter; Baltazar, Graça; Schwerk, Christian; Belin, Andrea Carmine; Tomás, Joana; Santos, Cecília Reis A.. "Experimental Tools to Study the Regulation and Function of the Choroid Plexus". In Blood-Brain Barrier (ISBN 978-1-4939-8945-4), 205-230. Springer New York, 2018.
    10.1007/978-1-4939-8946-1_13
  2. Gonçalves, Isabel. "Key Enzymes and Proteins in Amyloid-Beta Production and Clearance, Alzheimer's Disease Pathogenesis; Cecília R A Santos, Isabel Cardoso and Isabel Gonçalves". In Core Concepts, Shifting Paradigms and Therapeutic Targets,. Dr. Suzanne De La Monte (Ed.), InTech,, 2011.
Conference abstract
  1. Gonçalves, Isabel. "Expression and function of bitter taste receptors in the human blood-cerebrospinal fluid barrier (DOI: 10.1016/j.ibror.2019.07.1761)". Paper presented in September 2019, IBRO Reports 6:S560, 2019.
    Published
  2. Gonçalves, Isabel. "Circadian oscillation of Abeta-related molecules at the blood cerebrospinal fluid barrier (DOI: 10.1016/j.ibror.2019.07.1534)". Paper presented in IBRO, 2019.
    Published
  3. Gonçalves, Isabel. "The choroid plexus is a site of testosterone synthesis". Paper presented in 38th Congress of the Federation-of-European-Biochemical-Societies (FEBS), 2013.
    Published
  4. Gonçalves, Isabel. "Diabetes Insípida Familiar: Caracterização Clínica e identificação de uma nova mutação no gene da vasopressina". Paper presented in Diabetes and Metabolism, 2013.
    Published
  5. Gonçalves, Isabel. "Binding of nuclear proteins to the IVS2 region of the human A-gamma globin gene". Paper presented in The 11th Conference on Hemoglobin Switching, 1998.
    Published
Journal article
  1. Rafael Mineiro; Cecília Santos; Isabel Gonçalves; Manuel Lemos; José Eduardo B. Cavaco; Telma Quintela. "Regulation of ABC transporters by sex steroids may explain differences in drug resistance between sexes". Journal of Physiology and Biochemistry (2023): https://doi.org/10.1007/s13105-023-00957-1.
    10.1007/s13105-023-00957-1
  2. Ana R. Costa; Ana C. Duarte; Ana R. Costa-Brito; Isabel Gonçalves; Cecília R.A. Santos. "Bitter taste signaling in cancer". Life Sciences (2023): http://dx.doi.org/10.1016/j.lfs.2022.121363.
    10.1016/j.lfs.2022.121363
  3. André Furtado; André J. Esgalhado; Ana Catarina Duarte; Ana R. Costa; Ana R. Costa-Brito; Eva Carro; Hiroshi Ishikawa; et al. "Circadian rhythmicity of amyloid-beta-related molecules is disrupted in the choroid plexus of a female Alzheimer's disease mouse model". Journal of Neuroscience Research (2022): http://dx.doi.org/10.1002/jnr.25164.
    10.1002/jnr.25164
  4. "The druggability of bitter taste receptors for the treatment of neurodegenerative disorders". Biochemical Pharmacology 197 (2022): 114915-114915. http://dx.doi.org/10.1016/j.bcp.2022.114915.
    10.1016/j.bcp.2022.114915
  5. André Furtado; Rafael Mineiro; Ana Catarina Duarte; Isabel Gonçalves; Cecília R. Santos; Telma Quintela. "The Daily Expression of ABCC4 at the BCSFB Affects the Transport of Its Substrate Methotrexate". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23052443.
    10.3390/ijms23052443
  6. "The brain as a source and a target of prolactin in mammals". Neural Regeneration Research 17 8 (2022): 1695-1695. http://dx.doi.org/10.4103/1673-5374.332124.
    10.4103/1673-5374.332124
  7. "The role of circadian rhythm in choroid plexus functions". Progress in Neurobiology 205 (2021): 102129-102129. http://dx.doi.org/10.1016/j.pneurobio.2021.102129.
    10.1016/j.pneurobio.2021.102129
  8. Gonçalves, Isabel. "The crosstalk between melatonin and sex steroid hormones.". Neuroendocrinology (2021): https://doi.org/10.1159/000516148.
    10.1159/000516148
  9. Costa-Brito, A.R.; Quintela, T.; Gonçalves, I.; Duarte, A.C.; Costa, A.R.; Arosa, F.A.; Cavaco, J.E.; Lemos, M.C.; Santos, C.R.A.. "The Choroid Plexus Is an Alternative Source of Prolactin to the Rat Brain". Molecular Neurobiology (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85099015576&partnerID=MN8TOARS.
    10.1007/s12035-020-02267-9
  10. Alvelos, M.I.; Francisco, Â.; Gomes, L.; Paiva, I.; Melo, M.; Marques, P.; Gama-de-Sousa, S.; et al. "Familial neurohypophyseal diabetes insipidus: clinical, genetic and functional studies of novel mutations in the arginine vasopressin gene". Pituitary (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85099231925&partnerID=MN8TOARS.
    10.1007/s11102-020-01119-y
  11. Ana C. Duarte; André Furtado; Mariya V. Hrynchak; Ana R. Costa; Daniela Talhada; Isabel Gonçalves; Manuel C. Lemos; Telma Quintela; Cecília R.A. Santos. "Age, Sex Hormones, and Circadian Rhythm Regulate the Expression of Amyloid-Beta Scavengers at the Choroid Plexus". International Journal of Molecular Sciences (2020): https://doi.org/10.3390/ijms21186813.
    10.3390/ijms21186813
  12. Gonçalves, Isabel. "The Sex Bias of Cancer". Trends in Endocrinology & Metabolism (2020): http://dx.doi.org/10.1016/j.tem.2020.07.002.
    10.1016/j.tem.2020.07.002
  13. Gonçalves, Isabel. "Cadaverine and Spermine Elicit Ca2+ Uptake in Human CP Cells via a Trace Amine-Associated Receptor 1 Dependent Pathway". Journal of Molecular Neuroscience (2020): http://dx.doi.org/10.1007/s12031-020-01684-8.
    10.1007/s12031-020-01684-8
  14. Daniela Talhada; Ana Raquel Costa-Brito; Ana Catarina Duarte; Ana Raquel Costa; Telma Quintela; Joana Tomás; Isabel Gonçalves; Cecília Reis Alves Santos. "The choroid plexus: Simple structure, complex functions". Journal of Neuroscience Research (2020): https://doi.org/10.1002/jnr.24571.
    10.1002/jnr.24571
  15. Duarte, Ana C.; Santos, José; Costa, Ana R.; Ferreira, Catarina L.; Tomás, Joana; Quintela, Telma; Ishikawa, Hiroshi; et al. "Bitter taste receptors profiling in the human blood-cerebrospinal fluid-barrier". Biochemical Pharmacology (2020): 113954. http://dx.doi.org/10.1016/j.bcp.2020.113954.
    10.1016/j.bcp.2020.113954
  16. Duarte, Ana C.; Rosado, Tiago; Costa, Ana R.; Santos, José; Gallardo, Eugénia; Quintela, Telma; Ishikawa, Hiroshi; et al. "The bitter taste receptor TAS2R14 regulates resveratrol transport across the human blood-cerebrospinal fluid barrier". Biochemical Pharmacology (2020): 113953. http://dx.doi.org/10.1016/j.bcp.2020.113953.
    10.1016/j.bcp.2020.113953
  17. Furtado, A.; Astaburuaga, R.; Costa, A.; Duarte, A.C.; Goncalves, I.; Cipolla-Neto, J.; Lemos, M.C.; et al. "The Rhythmicity of Clock Genes is Disrupted in the Choroid Plexus of the APP/PS1 Mouse Model of Alzheimer's Disease". Journal of Alzheimer's Disease 77 2 (2020): 795-806. http://www.scopus.com/inward/record.url?eid=2-s2.0-85091469905&partnerID=MN8TOARS.
    10.3233/JAD-200331
  18. Talhada, D.; Gonçalves, I.; Gomes, J.C.; Saraiva, M.J.; Santos, C.R.; Ruscher, K.. "Erratum : Transthyretin expression in the postischemic brain (PLoS ONE 14:9 Doi: 10.1371/journal.pone.0221555)". PLoS ONE 15 6 June (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087100324&partnerID=MN8TOARS.
    10.1371/journal.pone.0235527
  19. Talhada, Daniela; Feiteiro, Joana; Costa, Ana Raquel; Talhada, Tiago; Cairrão, Elisa; Wieloch, Tadeusz; Englund, Elisabet; et al. "Triiodothyronine modulates neuronal plasticity mechanisms to enhance functional outcome after stroke". Acta Neuropathologica Communications 7 1 (2019): http://dx.doi.org/10.1186/s40478-019-0866-4.
    10.1186/s40478-019-0866-4
  20. Santos, C.R.A.; Duarte, A.C.; Costa, A.R.; Tomás, J.; Quintela, T.; Gonçalves, I.. "The senses of the choroid plexus". Progress in Neurobiology 182 (2019): 101680. http://dx.doi.org/10.1016/j.pneurobio.2019.101680.
    10.1016/j.pneurobio.2019.101680
  21. Talhada, Daniela; Santos, Cecília Reis Alves; Gonçalves, Isabel; Ruscher, Karsten. "Thyroid Hormones in the Brain and Their Impact in Recovery Mechanisms After Stroke". Frontiers in Neurology 10 (2019): http://dx.doi.org/10.3389/fneur.2019.01103.
    10.3389/fneur.2019.01103
  22. Talhada, Daniela; Gonçalves, Isabel; Reis Santos, Cecília; Ruscher, Karsten. "Transthyretin expression in the postischemic brain". PLOS ONE 14 9 (2019): e0221555. http://dx.doi.org/10.1371/journal.pone.0221555.
    10.1371/journal.pone.0221555
  23. Joana Tomás; Cecília R.A. Santos; Ana C. Duarte; Maria Maltez; Telma Quintela; Manuel C. Lemos; Isabel Gonçalves. "Bitter taste signaling mediated by Tas2r144 is down-regulated by 17ß-estradiol and progesterone in the rat choroid plexus". Molecular and Cellular Endocrinology 495 (2019): 110521-110521. https://doi.org/10.1016/j.mce.2019.110521.
    10.1016/j.mce.2019.110521
  24. Quintela, T.; Gonçalves, I.; Silva, M.; Duarte, A.C.; Guedes, P.; Andrade, K.; Freitas, F.; et al. "Choroid plexus is an additional source of melatonin in the brain". Journal of Pineal Research 65 4 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85055159557&partnerID=MN8TOARS.
    10.1111/jpi.12528
  25. Quintela, T.; Albuquerque, T.; Lundkvist, G.; Carmine Belin, A.; Talhada, D.; Gonçalves, I.; Carro, E.; Santos, C.R.A.. "The choroid plexus harbors a circadian oscillator modulated by estrogens". Chronobiology International 35 2 (2018): 270-279. http://www.scopus.com/inward/record.url?eid=2-s2.0-85035097479&partnerID=MN8TOARS.
    10.1080/07420528.2017.1400978
  26. Semo, A.C.; Carvalho, M.R.; Bogas, V.; Serra, A.; Lopes, V.; Brito, P.; Sá, F.B.; et al. "Allelic frequencies of 15 autosomal STRs from two main population groups (Makua and Changana) in Mozambique". Forensic Science International: Genetics Supplement Series (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85029759256&partnerID=MN8TOARS.
    10.1016/j.fsigss.2017.09.139
  27. Santos, C.R.A.; Duarte, A.C.; Quintela, T.; Tomás, J.; Albuquerque, T.; Marques, F.; Palha, J.A.; Gonçalves, I.. "The choroid plexus as a sex hormone target: Functional implications". Frontiers in Neuroendocrinology 44 (2017): 103-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008324860&partnerID=MN8TOARS.
    10.1016/j.yfrne.2016.12.002
  28. Costa, A.R.; Marcelino, H.; Gonçalves, I.; Quintela, T.; Tomás, J.; Duarte, A.C.; Fonseca, A.M.; Santos, C.R.A.. "Sex Hormones Protect Against Amyloid-ß Induced Oxidative Stress in the Choroid Plexus Cell Line Z310". Journal of Neuroendocrinology 28 9 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84986557055&partnerID=MN8TOARS.
    10.1111/jne.12404
  29. Duarte, A.C.; Hrynchak, M.V.; Gonçalves, I.; Quintela, T.; Santos, C.R.A.. "Sex Hormone Decline and Amyloid ß Synthesis, Transport and Clearance in the Brain". Journal of Neuroendocrinology 28 11 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84997109193&partnerID=MN8TOARS.
    10.1111/jne.12432
  30. Gonçalves, I.; Hubbard, P.C.; Tomás, J.; Quintela, T.; Tavares, G.; Caria, S.; Barreiros, D.; Santos, C.R.A.. "Smelling the cerebrospinal fluid: Olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus". FEBS Journal 283 9 (2016): 1748-1766. http://www.scopus.com/inward/record.url?eid=2-s2.0-84962788147&partnerID=MN8TOARS.
    10.1111/febs.13700
  31. Tomás, J.; Santos, C.R.A.; Quintela, T.; Gonçalves, I.. ""Tasting" the cerebrospinal fluid: Another function of the choroid plexus?". Neuroscience 320 (2016): 160-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958260325&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2016.01.057
  32. Quintela, T.; Marcelino, H.; Deery, M.J.; Feret, R.; Howard, J.; Lilley, K.S.; Albuquerque, T.; et al. "Sex-Related Differences in Rat Choroid Plexus and Cerebrospinal Fluid: A cDNA Microarray and Proteomic Analysis". Journal of Neuroendocrinology 28 1 (2016): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84956911885&partnerID=MN8TOARS.
    10.1111/jne.12340
  33. Quintela, T.; Sousa, C.; Patriarca, F.M.; Gonçalves, I.; Santos, C.R.. "Gender associated circadian oscillations of the clock genes in rat choroid plexus". Brain structure & function 220 3 (2015): 1251-1262. http://www.scopus.com/inward/record.url?eid=2-s2.0-84955597645&partnerID=MN8TOARS.
    10.1007/s00429-014-0720-1
  34. Quintela, T.; Marcelino, H.; Gonçalves, I.; Patriarca, F.M.; Santos, C.R.A.. "Gene Expression Profiling in the Hippocampus of Orchidectomized Rats". Journal of Molecular Neuroscience 55 1 (2014): 198-205. http://www.scopus.com/inward/record.url?eid=2-s2.0-84920841664&partnerID=MN8TOARS.
    10.1007/s12031-014-0304-9
  35. Martinho, A.; Santos, C.R.; Gonçalves, I.. "A distal estrogen responsive element upstream the cap site of human transthyretin gene is an enhancer-like element upon ERa and/or ERß transactivation". Gene 527 2 (2013): 469-476. http://www.scopus.com/inward/record.url?eid=2-s2.0-84881552032&partnerID=MN8TOARS.
    10.1016/j.gene.2013.06.078
  36. Quintela, T.; Gonçalves, I.; Carreto, L.C.; Santos, M.A.S.; Marcelino, H.; Patriarca, F.M.; Santos, C.R.A.. "Analysis of the Effects of Sex Hormone Background on the Rat Choroid Plexus Transcriptome by cDNA Microarrays". PLoS ONE 8 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876025530&partnerID=MN8TOARS.
    10.1371/journal.pone.0060199
  37. Martinho, A.; Gonçalves, I.; Santos, C.R.. "Glucocorticoids regulate metallothionein-1/2 expression in rat choroid plexus: Effects on apoptosis". Molecular and Cellular Biochemistry 376 1-2 (2013): 41-51. http://www.scopus.com/inward/record.url?eid=2-s2.0-84874282335&partnerID=MN8TOARS.
    10.1007/s11010-012-1547-9
  38. Martinho, A.; Gonçalves, I.; Costa, M.; Santos, C.R.. "Stress and glucocorticoids increase transthyretin expression in rat choroid plexus via mineralocorticoid and glucocorticoid receptors". Journal of Molecular Neuroscience 48 1 (2012): 1-13. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857295144&partnerID=MN8TOARS.
    10.1007/s12031-012-9715-7
  39. Santos, C.R.A.; Martinho, A.; Quintela, T.; Gonçalves, I.. "Neuroprotective and neuroregenerative properties of metallothioneins". IUBMB Life 64 2 (2012): 126-135. http://www.scopus.com/inward/record.url?eid=2-s2.0-84855863743&partnerID=MN8TOARS.
    10.1002/iub.585
  40. Quintela, T.; Gonçalves, I.; Martinho, A.; Alves, C.H.; Saraiva, M.J.; Rocha, P.; Santos, C.R.A.. "Progesterone enhances transthyretin expression in the rat choroid plexus in vitro and in vivo via progesterone receptor". Journal of Molecular Neuroscience 44 3 (2011): 152-158. http://www.scopus.com/inward/record.url?eid=2-s2.0-80054082420&partnerID=MN8TOARS.
    10.1007/s12031-010-9398-x
  41. Martinho, A.; Gonçalves, I.; Cardoso, I.; Almeida, M.R.; Quintela, T.; Saraiva, M.J.; Santos, C.R.A.. "Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin". FEBS Journal 277 16 (2010): 3427-3436. http://www.scopus.com/inward/record.url?eid=2-s2.0-77955239777&partnerID=MN8TOARS.
    10.1111/j.1742-4658.2010.07749.x
  42. Quintela, T.; Gonçalves, I.; Baltazar, G.; Alves, C.H.; Saraiva, M.J.; Santos, C.R.A.. "17ß-estradiol induces transthyretin expression in murine choroid plexus via an oestrogen receptor dependent pathway". Cellular and Molecular Neurobiology 29 4 (2009): 475-483. http://www.scopus.com/inward/record.url?eid=2-s2.0-67449156413&partnerID=MN8TOARS.
    10.1007/s10571-008-9339-1
  43. Alves, C.H.; Gonçalves, I.; Socorro, S.; Baltazar, G.; Quintela, T.; Santos, C.R.A.. "Androgen receptor is expressed in murine choroid plexus and downregulated by 5a-Dihydrotestosterone in male and female mice". Journal of Molecular Neuroscience 38 1 (2009): 41-49. http://www.scopus.com/inward/record.url?eid=2-s2.0-68949213641&partnerID=MN8TOARS.
    10.1007/s12031-008-9157-4
  44. Quintela, T.; Alves, C.H.; Gonçalves, I.; Baltazar, G.; Saraiva, M.J.; Santos, C.R.A.. "5a-dihydrotestosterone up-regulates transthyretin levels in mice and rat choroid plexus via an androgen receptor independent pathway". Brain Research 1229 (2008): 18-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-49849091809&partnerID=MN8TOARS.
    10.1016/j.brainres.2008.06.095
  45. Gonçalves, I.; Alves, C.H.; Quintela, T.; Baltazar, G.; Socorro, S.; Saraiva, M.J.; Abreu, R.; Santos, C.R.A.. "Transthyretin is up-regulated by sex hormones in mice liver". Molecular and Cellular Biochemistry 317 1-2 (2008): 137-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-53149110036&partnerID=MN8TOARS.
    10.1007/s11010-008-9841-2
  46. Gonçalves, I.; Quintela, T.; Baltazar, G.; Almeida, M.R.; Saraiva, M.J.M.; Santos, C.R.. "Transthyretin interacts with metallothionein 2". Biochemistry 47 8 (2008): 2244-2251. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749120520&partnerID=MN8TOARS.
    10.1021/bi7016377
  47. El-Shishtawy, R.M.; Santos, C.R.; Gonçalves, I.; Marcelino, H.; Almeida, P.. "New amino and acetamido monomethine cyanine dyes for the detection of DNA in agarose gels". Bioorganic and Medicinal Chemistry 15 16 (2007): 5537-5542. http://www.scopus.com/inward/record.url?eid=2-s2.0-34250717530&partnerID=MN8TOARS.
    10.1016/j.bmc.2007.05.043
  48. Gonçalves, I.; Henriques, A.; Raimundo, A.; Picanço, I.; Reis, A.; Correia Jr., E.; Santos, E.; Nogueira, P.; Osório-Almeida, L.. "Fetal hemoglobin elevation in Hb lepore heterozygotes and its correlation with ß globin cluster linked determinants". American Journal of Hematology 69 2 (2002): 95-102. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036156757&partnerID=MN8TOARS.
    10.1002/ajh.10019
  49. Gonçalves, I.; Lavinha, J.; Ducrocq, R.; Osório-Almeida, L.. "A novel rearrangement of the human fetal globin genes leading to a six ¿-globin gene haplotype". British Journal of Haematology 116 2 (2002): 454-457. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036182152&partnerID=MN8TOARS.
    10.1046/j.0007-1048.2001.03288.x
  50. Gonçalves, I.; Ducrocq, R.; Lavinha, J.; Nogueira, P.J.; Peres, M.J.; Picanço, I.; Correia Jr., E.; et al. "Combined effect of two different polymorphic sequences within the ß globin gene cluster on the level of HbF". American Journal of Hematology 57 4 (1998): 269-276. http://www.scopus.com/inward/record.url?eid=2-s2.0-2642595049&partnerID=MN8TOARS.
    10.1002/(SICI)1096-8652(199804)57:4<269::AID-AJH1>3.0.CO;2-S
  51. Gonçalves, I.; Gonçalves, J.; Périchon, B.; Osório-Almeida, L.; Krishnamoorthy, R.; Lavinha, J.. "A novel mosaic Bantu/Benin/Bantu ßshaplotype found in several African populations". Human Genetics 94 1 (1994): 101-103. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028284085&partnerID=MN8TOARS.
    10.1007/BF02272853
  52. Lu, C.Y.; Ragusa, A.; Goncalves, I.; Lapoumeroulie, C.; Krishnamoorthy, R.. "Molecular pathology of ß thalassemia intermedia". Nouvelle Revue Francaise d'Hematologie 35 3 (1993): 317-318. http://www.scopus.com/inward/record.url?eid=2-s2.0-0027204898&partnerID=MN8TOARS.
Thesis / Dissertation
  1. Gonçalves, Isabel. "Regulação da expressão dos genes da gamma globina humana". PhD, Universidade Nova de Lisboa, 2000.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017 - Current "Bitter Taste Signalling in Glioblastoma: Beyond Brain-Barriers"
Co-supervisor of Ana Raquel Ferreira da Costa
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2017 - Current "Is the choroid plexus an alternative source of prolactin to the central nervous system? Impact on neurogenesis"
Co-supervisor of Ana Raquel Costa Brito
Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2019 - 2020 "Analysis of the regulation of drug uptake and detoxification systems in the blood-cerebrospinal fluid barrier: the role of sex hormones and circadian rhythm".
Co-supervisor of Rafael Mineiro
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2016 - 2020 "The role of transthyretin and thyroid hormones on functional recovery after experimental stroke"
Co-supervisor of Daniela de Fátima Rua Matos Talhada
Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2015 - 2020 "Taste receptors in the Choroid Plexus are functional and regulated by sex hormones"
Supervisor of Joana Filipa Melfe Tomás
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2018 - 2019 "Is there a Role for Sweet Taste Receptors in the Warburg Effect, Angiogenesis and Cell Survival in Glioblastoma?"
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 "Análise da expressão e função dos recetores de compostos amargos no Plexo Coróide: estudo da resposta ao resveratrol"
Supervisor of José Alberto Canário dos Santos
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 "Developing A NGS Panel for Diagnosis of Lyme Disease and Its Co-Infections"
Supervisor of Eduardo Augusto Coelho
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2017 - 2018 "Are polyamines detected by TAAR receptor family in the human Choroid Plexus?"
Co-supervisor of Duarte Nuno de Almeida Santos e Lopes Rocha
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2015 - 2016 "Analysis of the expression of taste and olfactory receptors in choroid plexus and orbitofrontal cortex of Alzheimer¿s disease patients"
Supervisor of Vitória da Cunha Alves
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2014 - 2015 "Efeito do estradiol e do desregulador endócrino Bisfenol-A na via do paladar do Plexo Coróide"
Supervisor of Maria Duarte Maltez
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2013 - 2014 "O que será que o plexo coroide pode cheirar?"
Supervisor of Sandra Cristina Santos Caria
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2013 - 2014 " Circadian expression of Steroidogenic cytochromes P450 involved in metabolism of Xenobiotics in the rat Choroid plexus"
Co-supervisor of Andreia Filipa Trindade Domingos
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2012 - 2013 "Estudo Genético-Populacional dos Principais Grupos de Moçambique-Aplicação Forense"
Co-supervisor of Armando Cinturão Semo
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal

Universidade de Coimbra, Portugal
2012 - 2013 "Regulação da apoptose por hormonas sexuais no Plexo Coróide: implicações na clearence do beta-amiloide"
Co-supervisor of Ana Raquel Ferreira da Costa
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2012 - 2013 "Será que a maquinaria de transdução olfativa está presente no intestino?"
Supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2009 - 2013 "Transthyretin and metallothioneins affect amyloid-beta metabolism and are regulated by glucocorticoids in choroid plexus"
Co-supervisor of Ana de Jesus Martinho
 Biomedicina (PhD)
Universidade da Beira Interior, Portugal
2011 - 2012 "Identification of genetic mutations in patients with familial central diabetes insipidus"
Co-supervisor of Ângela Sofia Fernandes Alves Francisco
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2011 - 2012 "Será que o Plexo Coróide pode cheirar? "
Supervisor of Gabriela Pires Tavares
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal
2010 - 2011 "Efeito do 17-beta-estradiol na expressão da transtirretina e da metalotioneína-1/2 numa linha celular de plexo coroideu de rato"
Supervisor of Marta Isabel Nunes Costa
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2006 - 2007 "Será que a transtirretina humana interage com a metalotioneína 3?"
Supervisor of Sílvia Cláudia Gomes Coelho
 Bioquímica (Degree)
Universidade da Beira Interior, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020 Taste receptors in the Choroid Plexus are functional and regulated by sex hormones
Supervisor
 Joana Melfe Tomás (PhD)
Universidade da Beira Interior, Portugal
2013 Transthyretin and Metallothioneins affect amyloid-beta metabolism and are regulated by glucocorticoids in choroid plexus
Supervisor
 Ana Isabel Martinho (PhD)
2010 Regulação da transtirretina e do seu recetor em linhas celulares de fígado e plexo coroideu por hormonas esteróides
Thesis Member
 Telma Alexandra Quintela Paixão (PhD)
Universidade da Beira Interior, Portugal
2005 Análise Molecular dos Genes de gamma e de ß globina em ß talassémia na população marroquina
Thesis Member
 Wafaa Lemsaddek (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Committee member

Activity description
Role 		Institution / Organization
2018 - Current Comissão de Curso do 2ºciclo em Ciências Biomédicas
Member
 Universidade da Beira Interior, Portugal
2014 - Current Comissão de Curso do 2ºciclo em Bioquímica
Member
 Universidade da Beira Interior, Portugal
2009 - Current Comissão de Segurança Laboratorial do Centro de Investigação em Ciências da Saúde-Universidade da Beira Interior (CICS-UBI)
President / Vice-president
 Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2009 - 2017 Comissão de Horários da FCS da UBI
Member
 Universidade da Beira Interior, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018 - Current BASES CELULARES E MOLECULARES DA MEDICINA Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2016 - Current GENÉTICA Ciências Biomédicas (Licenciatura) Universidade da Beira Interior, Portugal
2010 - Current ROTAÇÕES LABORATORIAIS CLÍNICAS Biomedicina (Doutoramento) Universidade da Beira Interior, Portugal
2009 - Current BIOLOGIA MOLECULAR APLICADA Ciências Biomédicas (Mestrado integrado) Universidade da Beira Interior, Portugal
2010 - 2020 Sistema Nervoso e órgãos dos sentidos (CORPO HUMANO I) Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2010 - 2018 BIOTECNOLOGIA ALIMENTAR Biotecnologia (Licenciatura) Universidade da Beira Interior, Portugal
2009 - 2018 CORPO HUMANO I Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2010 - 2015 Aparelho digestivo (CORPO HUMANO II) Medicina (Mestrado integrado) Universidade da Beira Interior, Portugal
2005 - 2010 BIOLOGIA CELULAR E MOLECULAR Optometria - Ciências da Visão (Licenciatura) Universidade da Beira Interior, Portugal
1992 - 2000 GENÉTICA MOLECULAR II Química Aplicada (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1990 - 2000 GENÉTICA MOLECULAR I Química Aplicada (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1997 - 1997 INTRODUÇÃO À GENÉTICA MOLECULAR HUMANA Mestrado em Biologia Molecular Humana (Mestrado) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1992 - 1992 APLICAÇÕES DA ENGENHARIA GENÉTICA À BIOTECNOLOGIA Química Aplicada (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
1991 - 1991 ENGENHARIA GENÉTICA II Química Aplicada (Licenciatura) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
Distinctions

Other distinction

2019 Homenagem no livro Mulheres na Ciência (2ªedição)
Ciência Viva, Portugal