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LC Silva (LCS) is an Assistant Professor at the FF/ULisboa and Head of the Bioimaging Unit (2017/) at the iMed.ULisboa. She obtained her PhD in Chemistry/Molecular Biophysics (2006) at the Instituto Superior Técnico (IST) and her habilitation in Pharmaceutical Sciences/Biochemistry (2017) at the FF/ULisboa. She was a postdoc at the Weizmann Institute of Science (WIS). In 2011, she consolidated her independent research team - the Molecular & Cellular Biophysics (MCB) - that started under her appointment as Ciência 2008 Assistant Researcher (2009-2014) at the FF/ULisboa, followed by a FCT Investigator (2015-2020) research position. LCS has an interdisciplinary background in biochemistry & cell biology, quantitative photophysics & molecular biophysics. Her multidisciplinary research bridges membrane biophysics and cell biology, to tackle the role of membrane biophysical properties in cell function and pathology. Specifically, LCS is interested in lipids and their interplay in biological membranes, aiming to evaluate their role in membrane organization and function, and to provide the molecular tools to develop improved therapeutics. To support her independent research LCS secured competitive funding as PI of 4 FCT grants (ap 0.74ME), and as team member of 2 FCT-funded doctoral programs (M2B-PhD & i3DU) and 9 research projects (>2.5ME), including European collaborative projects. The output of LCS work includes 9 book chapters and 56 ISI papers in top specialty journals (80% in Q1), guest editor of 2 special issues dedicated to Sphingolipid research, and ap. 70 oral and 120 poster communications in conferences and seminars. The impact of the work is significant (>2800 citations, h-index=28) and widely recognized by the scientific community, as shown by the frequent invitations to participate as a speaker (> 40) and as a session chair in conferences of excellence, as EMBO and Gordon Research Conferences. During her career, LCS was awarded 2 FCT research positions (Ciência 2008 and FCT Investigator 2014), 2 fellowships (postdoc and PhD) and 18 grants from renowned scientific societies to participate in international conferences. LCS is associate editor of All Life (Taylor & Francis) and Cells (MDPI) journals, and editorial board member for Scientific Reports (Nature), Frontiers in membrane physiology and Frontiers in biophysics. LCS is evaluator of international projects, reviewer for several publishers, and was jury of several MSc and PhD theses. LCS is enrolled in activities supporting the training of students and early career researchers. More than 40 researchers, including 7 undergraduated students, 11 research fellows, 13 MsC, 9 PhD and 3 postdocs, developed or are currently developing work under her supervision. Of these, 7 MSc and 7 PhD students already obtained their degrees. LCS has also been involved in various teaching activities, including Biochemistry and Physics courses for MSc students, and implemented the Pharmaceutical Biophysics PhD course at the i3DU doctoral program. LCS is also engaged in science dissemination through the organization of meetings. In 2019 and 2023, she organized the FEBS Special Meeting in Sphingolipid Biology Series, one of the largest conferences in the field with over 200 participants, and co-organized in 2021, the 11th International Ceramide (virtual) Conference (www.sphingolipidbiology.com/icc). Moreover, in 2020, LCS created the Sphingolipid Biology web-based platform for researchers [website www.sphingolipidbiology.com, & social networks, twitter.com/SL_Biology, www.youtube.com/c/SphingolipidBiology], to promote science dissemination through the organization of live-webinars and conferences with leading experts, to advertise science-related activities and career opportunities, and to encourage regular meetings (every two weeks) and collaborations between researchers. It also aims to provide equal opportunities for all, in science dissemination activities.
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Identification

Personal identification

Full name
Liana C Silva

Citation names

  • Silva, Liana
  • Silva, Liana C

Author identifiers

Ciência ID
DB11-8C2D-AE3C
ORCID iD
0000-0003-1311-0770
Researcher Id
a-3025-2011
Scopus Author Id
8282140100

Knowledge fields

  • Natural sciences - Biological Sciences - Biophysics

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Advanced (C1) Beginner (A1) Intermediate (B1) Intermediate (B1)
French Beginner (A1) Elementary (A2) Beginner (A1) Beginner (A1)
Hebrew Beginner (A1) Beginner (A1)
Education
Degree Classification
2017/10
Concluded
 Agregação em Ciências Farmacêuticas/Habilitation in Pharmaceutical Sciences (Título de Agregado)
Major in Bioquímica/Biochemistry
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Pharmaceutical Biophysics" (THESIS/DISSERTATION)
 Aprovado com unanimidade/Unanimously approved
2006/11
Concluded
 Doutoramento em Química/PhD in Chemistry (Doutoramento)
Major in Biofísica Molecular / Molecular Biophysics
Universidade de Lisboa, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal
"Nystatin and Ceramide interaction with multicomponent model membranes: relating membrane biophysics with antibiotic action and apoptosis." (THESIS/DISSERTATION)
 Aprovado com unanimidade/Unanimously Approved
2001
Concluded
 Bioquímica/Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"Estudo das propriedades conformacionais e de oligomerização do antibiótico poliénico nistatina derivatizado com NBD por aplicação de técnicas de fluorescência" (THESIS/DISSERTATION)
 16/20
Affiliation

Science

Category
Host institution 		Employer
2015/02/02 - 2020/02/02 Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2014/09/01 - 2014/12/31 Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2009/07/01 - 2014/06/30 Auxiliary Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
2007/01/01 - 2009/06/30 Postdoc (Research) Fundação para a Ciência e a Tecnologia, Portugal
Weizmann Institute of Science, Israel
(...)

Teaching in Higher Education

Category
Host institution 		Employer
2020/12/31 - Current Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Lecturer (University Teacher) Universidade de Lisboa, Portugal
2016 - 2017 Lecturer (University Teacher) Universidade de Lisboa, Portugal
2014/07/01 - 2015/01/31 Invited Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014 Lecturer (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2011/01/01 - Current Group Leader "Molecular and Cellular Biophysics" Universidade de Lisboa Faculdade de Farmácia, Portugal
2003/05/01 - 2006/11/23 PhD student (Fellowship POCI 2010 SFRH/BD/10029/2002) Universidade de Lisboa Instituto Superior Técnico, Portugal
2002/09/01 - 2003/04/30 Graduate Research Fellow (POCTI/1999/QUI/36458/2001-2003) Universidade de Lisboa Instituto Superior Técnico, Portugal
2002/09/01 - 2003/04/30 Graduate Research Fellow (POCTI/1999/QUI/36458/2001-2003) Universidade de Lisboa Instituto Superior Técnico, Portugal
2001/08/01 - 2002/08/31 Graduate Research Fellow (PRAXIS/P/BIO/12049/1998-2002) Universidade de Lisboa Instituto Superior Técnico, Portugal
2000/09/01 - 2001/07/31 Undergraduate Research Fellow (Fellowship PRAXIS/P/BIO/12049/1998-2002) Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Grant

Designation Funders
2018 - Current Lysomod: Genetic and Small Molecule Modifiers of Lysosomal Function
H2020-MSCA-RISE-2016
Researcher
Instituto de Medicina Molecular, Portugal
 EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Ongoing
2017 - Current MultiNano@MBM: Modulation of melanoma-stroma interactions using a rationally-designed nanomedicine combining BRAFi-, MEKi- and immune-therapies
ENMed/0051/2016
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2017 - Current POINT4PAC: Precision Oncology By Innovative Therapies And Technologies
03/SAICT/2015 - SAICT (Programas de Atividades Conjuntas) 16405
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Ongoing
2018 - 2022 GD&PDBiophys: Exploring the biophysical link between Gaucher disease and Parkinson’s disease
PTDC/BIA-BFS/29448/2017
Principal investigator
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2022 TITANIC - CYP46A1 as a new TherapeutIcTAarget in NIemann-Pick type C disease
PTDC/MED-NEU/29455/2017
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2017/03 - 2021/02 Genetic and Small Molecule Modifiers of Lysosomal Function
734825
 European Commission
2016/05 - 2019/12 Biophysical and biological properties of atypical sphingolipids: implications to physiology and pathophysiology
Provided by PTCRIS: 142339
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2016 - 2019 NanoTumIm: Targeting tumor microenvironment by a translational multivalent nanomedicine: towards an effective anticancer combination immunotherapy
ENMed/0003/2015
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2019 RESYEAST: Sphingolipid organization in the plasma membrane of Saccharomyces cerevisiae. Implication in antifungal mode of action and fungal resistance
PTDC/BBB-BQB/6071/2014
Researcher
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2018 MultiNanoVac: Multidisciplinary Strategy to Develop Novel Multicomponent Nanoscale Systems for Immune Modulation
UTAP-ICDT/DTP-FTO/0016/2014,
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2016 COMBI-VIH: Multivalent nanoplatform for immune modulation to control HIV/AIDS infection
COMBI-VIH
Researcher
Gilead Sciences Lda
Concluded
2013/07 - 2015/06 Ceramide-Platforms: implication of membrane biophysical properties on ceramide biological outcome
124949
Provided by PTCRIS: 124949
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2012/02 - 2015/02 siRNA incorporation in a lipid/micelle-based nanocarrier as a strategy to restore E-cadherin expression and eradicate advanced breast cancer metastatic phenotype
Provided by PTCRIS: 120453
120453
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2011/01 - 2014/06 Ceramide and Glucosylceramide impact on membrane biophysical properties: from models of plasma- and lysosomal-membranes to the cell membrane
111411
Provided by PTCRIS: 111411
Principal investigator
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2010/01 - 2012/12 Targeting combined therapy to cancer stem cells
Provided by PTCRIS: 111412
111412
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2009/07 - 2011/12 Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network)
109361
Provided by PTCRIS: 109361
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2007/10 - 2010/09 Lipid Rafts, Ceramide, and Human Immunodeficiency Virus: a Biophysical Connection
Provided by PTCRIS: 68151
68151
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2007 - 2010 Understanding cell membrane lipid domains: from structure, biochemistry and theory to biology.
1735/07
Researcher
Israel Science Foundation
Concluded
2007/01/01 - 2009/06/30 SPHINGOLIPIDS AND CERAMIDE: FROM MODEL SYSTEMS TO CELL MEMBRANES AND ITS RELATION TO BIOLOGICAL PROCESSES
SFRH/BPD/30289/2006
Weizmann Institute of Science, Israel
 Fundação para a Ciência e a Tecnologia
Concluded
2007/01 - 2009/03 Molecular interactions in lipid raft models: from lipid phases to membrane protein organization
82384
Provided by PTCRIS: 82384
 Fundação para a Ciência e a Tecnologia, I.P.
2005/09 - 2008/06 Molecular interactions in lipid raft models: from lipid phases to membrane protein organization
Provided by PTCRIS: 57123
57123
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2005/06 - 2008/05 Molecular mechanism of inhibition of the vacuolar H+-ATPase of osteoclasts by potential antiosteporotic drugs
57114
Provided by PTCRIS: 57114
Researcher
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2003/05/01 - 2006/12/31 ESTUDO DA INTERACÇÃO DO ANTIBIÓTICO POLIÉNICO NISTATINA COM SISTEMAS MODELO DE BIOMEMBRANAS: INFLUÊNCIA DOS ESTERÓIS NO MECANISMO DE ACÇÃO A NÍVEL MOLECULAR
SFRH/BD/10029/2002
 Fundação para a Ciência e a Tecnologia
Concluded
2002 - 2003 The Effect of Membrane Microdomains on the Mode of Action of Polyene Antibiotics at the Molecular Level. The Role of Sterols.
POCTI/FCB/36389/1999
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2001 - 2002 Phase Behaviour of Biological Membrane Components: Kinetics, Thermodynamics, Composition and Topology. A Photophysical Study.
POCTI/QUI/36458/1999
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded
2000 - 2001 A Interacção do Péptido de Fusão da Proteína de Membrana do HIV-1, gp41, com Biomembranas e sua Inibição
PRAXIS/P/BIO/12049/1998
Research Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2015/02/02 - 2020/02/01 Lipid-lipid and lipid-drug interplay in biological membranes: from membrane lipid organization to membrane physiology
IF/00437/2014/CP1254/CT0003
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Institute of Nanoscience and Nanotechnology
UID/NAN/50024/2019
INESC Microsistemas e Nanotecnologias, Portugal

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/01/01 - 2019/12/31 Research Institute for Medicines
UID/DTP/04138/2019
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2016/05/02 - 2019/12/31 Biophysical and biological properties of atypical sphingolipids: implications to physiology and pathophysiology
PTDC/BBB-BQB/3710/2014
Universidade de Lisboa Centro de Química-Física Molecular, Portugal

Universität Zürich, Switzerland

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/06/01 - 2019/02/10 Multidisciplinary Strategy to Develop Novel Multicomponent Nanoscale Systems for Immune Modulation
UTAP-ICDT/DTP-FTO/0016/2014
Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade de Lisboa Instituto Dom Luiz, Portugal

Universitat Autònoma de Barcelona, Spain

The University of Texas at Austin, United States

Instituto Politécnico de Coimbra Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal

Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/07/01 - 2015/12/31 Ceramide-Platforms: implication of membrane biophysical properties on ceramide biological outcome
PTDC/BBB-BQB/0506/2012
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química-Física Molecular, Portugal

Weizmann Institute of Science, Israel

Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2012/02/02 - 2015/09/30 siRNA incorporation in a lipid/micelle-based nanocarrier as a strategy to restore E-cadherin expression and eradicate advanced breast cancer metastatic phenotype
PTDC/SAU-FAR/120453/2010
Instituto Politécnico de Coimbra Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal

Institut d'Investigació Biomèdica de Bellvitge, Spain

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2014/06/30 Ceramide and Glucosylceramide impact on membrane biophysical properties: from models of plasma- and lysosomal-membranes to the cell membrane
PTDC/QUI-BIQ/111411/2009
Instituto Politécnico de Coimbra Centro de Estudos de Recursos Naturais Ambiente e Sociedade, Portugal

Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química-Física Molecular, Portugal

Weizmann Institute of Science, Israel
Fundação para a Ciência e a Tecnologia
Concluded
2009/07/01 - 2014/06/30 Not Available
CONT_DOUT/17/FF-UL/182/9857/ 10/2008
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Strategic Project - UI 4013 - 2011-2012
PEst-OE/SAU/UI4013/2011
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009/07/01 - 2011/12/31 Advancing the field of drug delivery - combined targeted treatments against human breast cancer and human leukemia (The OncotargetNanoMed network)
NANO/NMed-AT/0042/2007
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Aveiro, Portugal

Universidade do Minho, Portugal

Universidade de Aveiro CICECO, Portugal

Universidade de Lisboa Faculdade de Farmácia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/09/01 - 2008/06/30 Molecular interactions in lipid raft models: from lipid phases to membrane protein organization
POCI/QUI/57123/2004
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química-Física Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2005/06/01 - 2008/05/31 Molecular mechanism of inhibition of the vacuolar H+-ATPase of osteoclasts by potential antiosteporotic drugs
POCI/SAU-FCF/57114/2004
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Centro de Química-Física Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Ventura, A.E.; Santos, T.C.B.; Marquês, J.T.; de Almeida, R.F.M.; Silva, L.C.. "Biophysical analysis of lipid domains by fluorescence microscopy". 223-245. 2021.
    10.1007/978-1-0716-0814-2_13
  2. Sousa, C.; Santos, F.C.; Bento-Oliveira, A.; Mestre, B.; Silva, L.C.; de Almeida, R.F.M.. "Biophysical analysis of lipid domains in mammalian and yeast membranes by fluorescence spectroscopy". 247-269. 2021.
    10.1007/978-1-0716-0814-2_14
  3. Ventura, A.E.; Santos, T.; Carreira, A.C.; Martinho, N.M.; Conniot, J.; Varela, A.R.P.; Gaspar, R.; Florindo, H.F.; Silva, L.C.. "DRUGS, DELIVERY SYSTEMS AND MEMBRANE ORGANIZATION IN MODEL AND CELL MEMBRANES". 179-214. 2020.
  4. Ventura, Ana E.; Mestre, Beatriz; Silva, Liana C.. "Ceramide Domains in Health and Disease: A Biophysical Perspective". In Advances in Experimental Medicine and Biology, 79-108. Springer International Publishing, 2019.
    10.1007/978-3-030-21162-2_6
  5. Silva, A.L.; Moura, L.I.F.; Carreira, B.; Conniot, J.; Matos, A.I.; Peres, C.; Sainz, V.; et al. "Functional Moieties for Intracellular Traffic of Nanomaterials". 399-448. 2018.
  6. Florindo, H.F.; Lopes, J.; Silva, L.C.; Corvo, M.L.; Martins, M.B.; Gaspar, R.. "Regulatory Development of Nanotechnology-Based Vaccines". In Biomedical Applications of Functionalized Nanomaterials. 2016.
    10.1016/B978-0-323-39981-4.00021-X
  7. Ventura, A.E.; Santos, T.; Carreira, A.C.; Martinho, N.M.; Conniot, J.; Varela, A.R.P.; Gaspar, R.; Florindo, H.F.; Silva, L.C.. "Drugs, delivery systems and membrane organization in model and cell membranes". In Biomedical Applications of Functionalized Nanomaterials. 2016.
  8. de Almeida, R.F.M.; Marquês, J.T.; Silva, L.C.. "Biophysics of lipid rafts and their interplay with ceramide: Studies in model systems and biological insights". In Biomedical Applications of Functionalized Nanomaterials. 2014.
  9. Gaspar, Rogério S.; Florindo, Helena F.; Silva, Liana C.; Videira, Mafalda A.; Corvo, M. Luísa; Martins, Bárbara F.; Silva-Lima, Beatriz. "Regulatory Aspects of Oncologicals: Nanosystems Main Challenges". In Advances in Delivery Science and Technology, 425-452. Springer International Publishing, 2014.
    10.1007/978-3-319-08084-0_15
  10. Silva, Liana C; Florindo, Helena F.. "Immunomodulation against microbial pathogens through dendritic cells". In Microbial pathogens and strategies for combating them. Badajoz, Spain: Formatex Research Center,, 2013.
    Published
Journal article
  1. Peres, Carina; Matos, Ana I.; Carreira, Bárbara; Moura, Liane I. F.; Kleiner, Ron; Vaskovich-Koubi, Daniella; Reshef, Keren; et al. "Multifunctional Nanovaccine Sensitizes Breast Cancer to Immune Checkpoint Therapy". Advanced Functional Materials (2024): http://dx.doi.org/10.1002/adfm.202401749.
    10.1002/adfm.202401749
  2. Martinho, Nuno; Marquês, Joaquim M. T.; Todoriko, Iryna; Prieto, Manuel; de Almeida, Rodrigo F.M.; Silva, Liana C.. "Effect of Cisplatin and Its Cationic Analogues in the Phase Behavior and Permeability of Model Lipid Bilayers". Molecular Pharmaceutics 20 2 (2023): 918-928. http://dx.doi.org/10.1021/acs.molpharmaceut.2c00321.
    10.1021/acs.molpharmaceut.2c00321
  3. Afonso, M.B.; Islam, T.; Magusto, J.; Amorim, R.; Lenoir, V.; Simões, R.F.; Teixeira, J.; et al. "RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease". Hepatology 77 4 (2023): 1319-1334. http://www.scopus.com/inward/record.url?eid=2-s2.0-85139673348&partnerID=MN8TOARS.
    10.1002/hep.32756
  4. Matos, A.I.; Peres, C.; Carreira, B.; Moura, L.I.F.; Acúrcio, R.C.; Vogel, T.; Wegener, E.; et al. "Polyoxazoline-Based Nanovaccine Synergizes with Tumor-Associated Macrophage Targeting and Anti-PD-1 Immunotherapy against Solid Tumors". Advanced Science 10 25 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85164453502&partnerID=MN8TOARS.
    10.1002/advs.202300299
  5. Ventura, A.E.; Pokorna, S.; Huhn, N.; Santos, T.C.B.; Prieto, M.; Futerman, A.H.; Silva, L.C.. "Cell lipid droplet heterogeneity and altered biophysical properties induced by cell stress and metabolic imbalance". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1868 9 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85161264047&partnerID=MN8TOARS.
    10.1016/j.bbalip.2023.159347
  6. Pokorna, Sarka; Ventura, Ana E.; Santos, Tânia C.B.; Hof, Martin; Prieto, Manuel; Futerman, Anthony H.; Silva, Liana C.. "Laurdan in live cell imaging: Effect of acquisition settings, cell culture conditions and data analysis on generalized polarization measurements". Journal of Photochemistry and Photobiology B: Biology (2022): 112404. http://dx.doi.org/10.1016/j.jphotobiol.2022.112404.
    10.1016/j.jphotobiol.2022.112404
  7. Aslan, M.; Oztas, Y.; Silva, L.C.. "Editorial: Bioactive sphingolipids in health and disease". Frontiers in Molecular Biosciences 9 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85140395661&partnerID=MN8TOARS.
    10.3389/fmolb.2022.1051449
  8. de Almeida, R.F.M.; Santos, T.C.B.; da Silva, L.C.; Suchodolski, J.; Krasowska, A.; Stokowa-Soltys, K.; Puchalska, M.; Starosta, R.. "NBD derived diphenyl(aminomethyl)phosphane – A new fluorescent dye for imaging of low pH regions and lipid membranes in living cells". Dyes and Pigments 184 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85090212613&partnerID=MN8TOARS.
    10.1016/j.dyepig.2020.108771
  9. Santos, T.C.B.; Saied, E.M.; Arenz, C.; Fedorov, A.; Prieto, M.; Silva, L.C.. "The long chain base unsaturation has a stronger impact on 1-deoxy(methyl)-sphingolipids biophysical properties than the structure of its C1 functional group". Biochimica et Biophysica Acta - Biomembranes 1863 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105828907&partnerID=MN8TOARS.
    10.1016/j.bbamem.2021.183628
  10. Carreira, A.C.; Pokorna, S.; Ventura, A.E.; Walker, M.W.; Futerman, A.H.; Lloyd-Evans, E.; de Almeida, R.F.M.; Silva, L.C.. "Biophysical impact of sphingosine and other abnormal lipid accumulation in Niemann-Pick disease type C cell models". Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1866 8 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85105045187&partnerID=MN8TOARS.
    10.1016/j.bbalip.2021.158944
  11. Tania C.B. Santos; Alexandra Vaz; Ana E. Ventura; Essa M. Saied; Christoph Arenz; Aleksander Fedorov; Manuel Prieto; Liana C. Silva. "Canonical and 1-Deoxy(methyl) Sphingoid Bases: Tackling the Effect of the Lipid Structure on Membrane Biophysical Properties". Langmuir (2020): https://doi.org/10.1021/acs.langmuir.0c01000.
    10.1021/acs.langmuir.0c01000
  12. Zelnik, Iris D.; Ventura, Ana E.; Kim, Jiyoon L.; Silva, Liana C.; Futerman, Anthony H.. "The role of ceramide in regulating endoplasmic reticulum function". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1865 1 (2020): 158489. http://dx.doi.org/10.1016/j.bbalip.2019.06.015.
    10.1016/j.bbalip.2019.06.015
  13. Clarke, C.J.; D'Angelo, G.; Silva, L.C.. "Sphingolipid metabolism and signaling: embracing diversity". FEBS Letters 594 22 (2020): 3579-3582. http://www.scopus.com/inward/record.url?eid=2-s2.0-85096560949&partnerID=MN8TOARS.
    10.1002/1873-3468.13979
  14. Ventura, A.E.; Varela, A.R.P.; Dingjan, T.; Santos, T.C.B.; Fedorov, A.; Futerman, A.H.; Prieto, M.; Silva, L.C.. "Lipid domain formation and membrane shaping by C24-ceramide". Biochimica et Biophysica Acta - Biomembranes 1862 10 (2020): http://www.scopus.com/inward/record.url?eid=2-s2.0-85087383695&partnerID=MN8TOARS.
    10.1016/j.bbamem.2020.183400
  15. D'Angelo, Giovanni; Clarke, Christopher J.; Silva, Liana C.. "Meeting Report – The 2019 FEBS special meeting on sphingolipid biology: sphingolipids in physiology and pathology". Journal of Cell Science 132 15 (2019): jcs235705. http://dx.doi.org/10.1242/jcs.235705.
    Published • 10.1242/jcs.235705
  16. Carreira, A.C.; Santos, T.C.; Lone, M.A.; Zupancic, E.; Lloyd-Evans, E.; de Almeida, R.F.M.; Hornemann, T.; Silva, L.C.. "Mammalian sphingoid bases: Biophysical, physiological and pathological properties". Progress in Lipid Research 75 (2019): 100988. http://dx.doi.org/10.1016/j.plipres.2019.100988.
    10.1016/j.plipres.2019.100988
  17. Lone, M.A.; Santos, T.; Alecu, I.; Silva, L.C.; Hornemann, T.. "1-Deoxysphingolipids". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids 1864 4 (2019): 512-521. http://dx.doi.org/10.1016/j.bbalip.2018.12.013.
    10.1016/j.bbalip.2018.12.013
  18. Martinho, Nuno; Santos, Tânia C. B.; Florindo, Helena F.; Silva, Liana C.. "Cisplatin-Membrane Interactions and Their Influence on Platinum Complexes Activity and Toxicity". Frontiers in Physiology 9 (2019): http://dx.doi.org/10.3389/fphys.2018.01898.
    10.3389/fphys.2018.01898
  19. Lopes, Ricardo M. R. M.; Ventura, Ana E.; Silva, Liana C.; Faustino, Hélio; Gois, Pedro M. P.. "N,O -Iminoboronates: Reversible Iminoboronates with Improved Stability for Cancer Cells Targeted Delivery". Chemistry - A European Journal 24 48 (2018): 12495-12499. http://dx.doi.org/10.1002/chem.201802515.
    10.1002/chem.201802515
  20. Martinho, N.; Silva, L.C.; Florindo, H.F.; Brocchini, S.; Barata, T.; Zloh, M.. "Practical computational toolkits for dendrimers and dendrons structure design". Journal of Computer-Aided Molecular Design 31 9 (2017): 817-827. http://www.scopus.com/inward/record.url?eid=2-s2.0-85029512089&partnerID=MN8TOARS.
    10.1007/s10822-017-0041-6
  21. Dos Santos, A.G.; Marquês, J.T.; Carreira, A.C.; Castro, I.R.; Viana, A.S.; Mingeot-Leclercq, M.-P.; De Almeida, R.F.M.; Silva, L.C.. "The molecular mechanism of Nystatin action is dependent on the membrane biophysical properties and lipid composition". Physical Chemistry Chemical Physics 19 44 (2017): 30078-30088. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034607359&partnerID=MN8TOARS.
    10.1039/c7cp05353c
  22. Moura, L.I.F.; Martinho, N.; Silva, L.C.; Barata, T.S.; Brocchini, S.; Florindo, H.F.; Zloh, M.. "Poly-glutamic dendrimer-based conjugates for cancer vaccination–a computational design for targeted delivery of antigens". Journal of Drug Targeting 25 9-10 (2017): 873-880. http://www.scopus.com/inward/record.url?eid=2-s2.0-85027096822&partnerID=MN8TOARS.
    10.1080/1061186X.2017.1363213
  23. dos Santos, A.G.; Bayiha, J.C.; Dufour, G.; Cataldo, D.; Evrard, B.; Silva, L.C.; Deleu, M.; Mingeot-Leclercq, M.-P.. "Changes in membrane biophysical properties induced by the Budesonide/Hydroxypropyl-ß-cyclodextrin complex". Biochimica et Biophysica Acta - Biomembranes 1859 10 (2017): 1930-1940. http://www.scopus.com/inward/record.url?eid=2-s2.0-85021777207&partnerID=MN8TOARS.
    10.1016/j.bbamem.2017.06.010
  24. Carreira, A.C.; De Almeida, R.F.M.; Silva, L.C.. "Development of lysosome-mimicking vesicles to study the effect of abnormal accumulation of sphingosine on membrane properties". Scientific Reports 7 1 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85021198259&partnerID=MN8TOARS.
    10.1038/s41598-017-04125-6
  25. Martinho, N.; Silva, L.C.; Florindo, H.F.; Brocchini, S.; Zloh, M.; Barata, T.S.. "Rational design of novel, fluorescent, tagged glutamic acid dendrimers with different terminal groups and in silico analysis of their properties". International Journal of Nanomedicine 12 (2017): 7053-7073. http://www.scopus.com/inward/record.url?eid=2-s2.0-85030233633&partnerID=MN8TOARS.
    10.2147/IJN.S135475
  26. Varela, A.R.P.; Ventura, A.E.; Carreira, A.C.; Fedorov, A.; Futerman, A.H.; Prieto, M.; Silva, L.C.. "Pathological levels of glucosylceramide change the biophysical properties of artificial and cell membranes†". Physical Chemistry Chemical Physics 19 1 (2017): 340-346. http://www.scopus.com/inward/record.url?eid=2-s2.0-85039864131&partnerID=MN8TOARS.
    10.1039/c6cp07227e
  27. Santos, F.M.F.; Rosa, J.N.; Candeias, N.R.; Carvalho, C.P.; Matos, A.I.; Ventura, A.E.; Florindo, H.F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry - A European Journal 22 44 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84950262633&partnerID=MN8TOARS.
    10.1002/chem.201504857
  28. Varela, A.R.P.; Couto, A.S.; Fedorov, A.; Futerman, A.H.; Prieto, M.; Silva, L.C.. "Glucosylceramide Reorganizes Cholesterol-Containing Domains in a Fluid Phospholipid Membrane". Biophysical Journal 110 3 (2016): 612-622. http://www.scopus.com/inward/record.url?eid=2-s2.0-84963752947&partnerID=MN8TOARS.
    10.1016/j.bpj.2015.12.019
  29. Santos, F.M.F.; Rosa, J.N.; Candeias, N.R.; Carvalho, C.P.; Matos, A.I.; Ventura, A.E.; Florindo, H.F.; et al. "A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes)". Chemistry - A European Journal 22 5 (2016): 1631-1637. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958037809&partnerID=MN8TOARS.
    10.1002/chem.201503943
  30. Carreira, A.C.; Ventura, A.E.; Varela, A.R.P.; Silva, L.C.. "Tackling the biophysical properties of sphingolipids to decipher their biological roles". Biological Chemistry 396 6-7 (2015): 597-609. http://www.scopus.com/inward/record.url?eid=2-s2.0-84940046039&partnerID=MN8TOARS.
    10.1515/hsz-2014-0283
  31. Sainz, V.; Conniot, J.; Matos, A.I.; Peres, C.; Zupancic, E.; Moura, L.; Silva, L.C.; Florindo, H.F.; Gaspar, R.S.. "Regulatory aspects on nanomedicines". Biochemical and Biophysical Research Communications 468 3 (2015): 504-510. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951569805&partnerID=MN8TOARS.
    10.1016/j.bbrc.2015.08.023
  32. Zupancic, E.; Carreira, A.C.; De Almeida, R.F.M.; Silva, L.C.. "Biophysical implications of sphingosine accumulation in membrane properties at neutral and acidic pH". Journal of Physical Chemistry B 118 18 (2014): 4858-4866. http://www.scopus.com/inward/record.url?eid=2-s2.0-84900295816&partnerID=MN8TOARS.
    10.1021/jp501167f
  33. Silva, J.M.; Vandermeulen, G.; Oliveira, V.G.; Pinto, S.N.; Rodrigues, C.; Salgado, A.; Afonso, C.A.; et al. "Development of functionalized nanoparticles for vaccine delivery to dendritic cells: A mechanistic approach". Nanomedicine 9 17 (2014): 2639-2656. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919788438&partnerID=MN8TOARS.
    10.2217/nnm.14.135
  34. Conniot, J.; Silva, J.M.; Fernandes, J.G.; Silva, L.C.; Gaspar, R.; Brocchini, S.; Florindo, H.F.; Barata, T.S.. "Cancer immunotherapy: Nanodelivery approaches for immune cell targeting and tracking". Frontiers in Chemistry 2 NOV (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84987618944&partnerID=MN8TOARS.
    10.3389/fchem.2014.00105
  35. Castro, B.M.; Prieto, M.; Silva, L.C.. "Ceramide: A simple sphingolipid with unique biophysical properties". Progress in Lipid Research 54 1 (2014): 53-67. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896727262&partnerID=MN8TOARS.
    10.1016/j.plipres.2014.01.004
  36. Varela, A.R.P.; Gonçalves Da Silva, A.M.P.S.; Fedorov, A.; Futerman, A.H.; Prieto, M.; Silva, L.C.. "Influence of intracellular membrane pH on sphingolipid organization and membrane biophysical properties". Langmuir 30 14 (2014): 4094-4104. http://www.scopus.com/inward/record.url?eid=2-s2.0-84898879727&partnerID=MN8TOARS.
    10.1021/la5003397
  37. Martinho, N.; Florindo, H.; Silva, L.; Brocchini, S.; Zloh, M.; Barata, T.. "Molecular modeling to study dendrimers for biomedical applications". Molecules 19 12 (2014): 20424-20467. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919742776&partnerID=MN8TOARS.
    10.3390/molecules191220424
  38. Pinto, S.N.; Laviad, E.L.; Stiban, J.; Kelly, S.L.; Merrill Jr., A.H.; Prieto, M.; Futerman, A.H.; Silva, L.C.. "Changes in membrane biophysical properties induced by sphingomyelinase depend on the sphingolipid N -acyl chain". Journal of Lipid Research 55 1 (2014): 53-61. http://www.scopus.com/inward/record.url?eid=2-s2.0-84891350435&partnerID=MN8TOARS.
    10.1194/jlr.M042002
  39. Pinto, S.N.; Fernandes, F.; Fedorov, A.; Futerman, A.H.; Silva, L.C.; Prieto, M.. "A combined fluorescence spectroscopy, confocal and 2-photon microscopy approach to re-evaluate the properties of sphingolipid domains". Biochimica et Biophysica Acta - Biomembranes 1828 9 (2013): 2099-2110. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879228705&partnerID=MN8TOARS.
    10.1016/j.bbamem.2013.05.011
  40. Varela, A.R.P.; Gonçalves Da Silva, A.M.P.S.; Fedorov, A.; Futerman, A.H.; Prieto, M.; Silva, L.C.. "Effect of glucosylceramide on the biophysical properties of fluid membranes". Biochimica et Biophysica Acta - Biomembranes 1828 3 (2013): 1122-1130. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872166522&partnerID=MN8TOARS.
    10.1016/j.bbamem.2012.11.018
  41. Singh, A.; Wang, H.; Silva, L.C.; Na, C.; Prieto, M.; Futerman, A.H.; Luberto, C.; Del Poeta, M.. "Methylation of glycosylated sphingolipid modulates membrane lipid topography and pathogenicity of Cryptococcus neoformans". Cellular Microbiology 14 4 (2012): 500-516. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862818711&partnerID=MN8TOARS.
    10.1111/j.1462-5822.2011.01735.x
  42. Silva, L.C.; David, O.B.; Pewzner-Jung, Y.; Laviad, E.L.; Stiban, J.; Bandyopadhyay, S.; Merrill Jr., A.H.; Prieto, M.; Futerman, A.H.. "Ablation of ceramide synthase 2 strongly affects biophysical properties of membranes". Journal of Lipid Research 53 3 (2012): 430-436. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857762476&partnerID=MN8TOARS.
    10.1194/jlr.M022715
  43. Pinto, S.N.; Silva, L.C.; Futerman, A.H.; Prieto, M.. "Effect of ceramide structure on membrane biophysical properties: The role of acyl chain length and unsaturation". Biochimica et Biophysica Acta - Biomembranes 1808 11 (2011): 2753-2760. http://www.scopus.com/inward/record.url?eid=2-s2.0-80052265605&partnerID=MN8TOARS.
    10.1016/j.bbamem.2011.07.023
  44. Pewzner-Jung, Y.; Park, H.; Laviad, E.L.; Silva, L.C.; Lahiri, S.; Stiban, J.; Erez-Roman, R.; et al. "A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways". Journal of Biological Chemistry 285 14 (2010): 10902-10910. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951234061&partnerID=MN8TOARS.
    10.1074/jbc.M109.077594
  45. Silva, L.C.; Futerman, A.H.; Prieto, M.. "Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations". Biophysical Journal 96 8 (2009): 3210-3222. http://www.scopus.com/inward/record.url?eid=2-s2.0-67649410710&partnerID=MN8TOARS.
    10.1016/j.bpj.2008.12.3923
  46. Castro, B.M.; Silva, L.C.; Fedorov, A.; de Almeida, R.F.M.; Prieto, M.. "Cholesterol-rich fluid membranes solubilize ceramide domains: Implications for the structure and dynamics of mammalian intracellular and plasma membranes". Journal of Biological Chemistry 284 34 (2009): 22978-22987. http://www.scopus.com/inward/record.url?eid=2-s2.0-69249087317&partnerID=MN8TOARS.
    10.1074/jbc.M109.026567
  47. Loura, L.M.S.; de Almeida, R.F.M.; Silva, L.C.; Prieto, M.. "FRET analysis of domain formation and properties in complex membrane systems". Biochimica et Biophysica Acta - Biomembranes 1788 1 (2009): 209-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149201036&partnerID=MN8TOARS.
    10.1016/j.bbamem.2008.10.012
  48. Pinto, S.N.; Silva, L.C.; De Almeida, R.F.M.; Prieto, M.. "Membrane domain formation, interdigitation, and morphological alterations induced by the very long chain asymmetric C24:1 ceramide". Biophysical Journal 95 6 (2008): 2867-2879. http://www.scopus.com/inward/record.url?eid=2-s2.0-55549135378&partnerID=MN8TOARS.
    10.1529/biophysj.108.129858
  49. Stiban, J.; Silva, L.C.; Futerman, A.H.. "Ceramide-containing membranes: The interface between biophysics and biology". Trends in Glycoscience and Glycotechnology 20 116 (2008): 297-313. http://www.scopus.com/inward/record.url?eid=2-s2.0-60849131885&partnerID=MN8TOARS.
    10.4052/tigg.20.297
  50. Silva, L.C.; De Almeida, R.F.M.; Castro, B.M.; Fedorov, A.; Prieto, M.. "Ceramide-domain formation and collapse in lipid rafts: Membrane reorganization by an apoptotic lipid". Biophysical Journal 92 2 (2007): 502-516. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846411845&partnerID=MN8TOARS.
    10.1529/biophysj.106.091876
  51. Castro, B.M.; De Almeida, R.F.M.; Silva, L.C.; Fedorov, A.; Prieto, M.. "Formation of ceramide/sphingomyelin gel domains in the presence of an unsaturated phospholipid: A quantitative multiprobe approach". Biophysical Journal 93 5 (2007): 1639-1650. http://www.scopus.com/inward/record.url?eid=2-s2.0-34548629303&partnerID=MN8TOARS.
    10.1529/biophysj.107.107714
  52. Silva, L.; Coutinho, A.; Fedorov, A.; Prieto, M.. "Nystatin-induced lipid vesicles permeabilization is strongly dependent on sterol structure". Biochimica et Biophysica Acta - Biomembranes 1758 4 (2006): 452-459. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646785059&partnerID=MN8TOARS.
    10.1016/j.bbamem.2006.03.008
  53. Silva, L.; De Almeida, R.F.M.; Fedorov, A.; Matos, A.P.A.; Prieto, M.. "Ceramide-platform formation and -induced biophysical changes in a fluid phospholipid membrane". Molecular Membrane Biology 23 2 (2006): 137-150. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646880484&partnerID=MN8TOARS.
    10.1080/09687860500439474
  54. Silva, L.; Coutinho, A.; Fedorov, A.; Prieto, M.. "Competitive binding of cholesterol and ergosterol to the polyene antibiotic nystatin. A fluorescence study". Biophysical Journal 90 10 (2006): 3625-3631. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646201285&partnerID=MN8TOARS.
    10.1529/biophysj.105.075408
  55. Coutinho, A.; Silva, L.; Fedorov, A.; Prieto, M.. "Cholesterol and ergosterol influence nystatin surface aggregation: Relation to pore formation". Biophysical Journal 87 5 (2004): 3264-3276. http://www.scopus.com/inward/record.url?eid=2-s2.0-16344382233&partnerID=MN8TOARS.
    10.1529/biophysj.104.044883
  56. Silva, L.; Coutinho, A.; Fedorov, A.; Prieto, M.. "Conformation and self-assembly of a nystatin nitrobenzoxadiazole derivative in lipid membranes". Biochimica et Biophysica Acta - Biomembranes 1617 1-2 (2003): 69-79. http://www.scopus.com/inward/record.url?eid=2-s2.0-0345017109&partnerID=MN8TOARS.
    10.1016/j.bbamem.2003.09.004
  57. Silva, L.; Coutinho, A.; Fedorov, A.; Prieto, M.. "Solution conformation of a nitrobenzoxadiazole derivative of the polyene antibiotic nystatin: A FRET study". Journal of Photochemistry and Photobiology B: Biology 72 1-3 (2003): 17-26. http://www.scopus.com/inward/record.url?eid=2-s2.0-0344237181&partnerID=MN8TOARS.
    10.1016/j.jphotobiol.2003.08.005
Journal issue
  1. Mutay Aslam; Yezim Otsas; Silva, Liana C. "Bioactive Sphingolipids in Health and Disease". Frontiers in Molecular Biosciences (2022): https://www.frontiersin.org/research-topics/24816/bioactive-sphingolipids-in-health-and-disease.
    In press • Associated editor
  2. Silva, Liana C. "FEBS Letters Special Issue in Sphingolipid Biology". FEBS Letters 594 22 (2020): https://febs.onlinelibrary.wiley.com/toc/18733468/2020/594/22.
    Accepted • Editor
Online resource
  1. Silva, Liana C; D'Angelo, Giovanni; Clarke, Christopher J.. Sphingolipid Biology Webinars. 2020. https://www.youtube.com/c/SphingolipidBiology.
  2. Silva, Liana C; D'Angelo, Giovanni; Clarke, Christopher J.. YouTube channel with scientific webinars. 2020. https://www.youtube.com/c/SphingolipidBiology/.
Thesis / Dissertation
  1. Riachos, Duarte Miguel de Amado. "Doença de Gaucher e Doença de Parkinson:". Master, 2022. http://hdl.handle.net/10451/57992.
  2. Bernardino, Bárbara Inês Lobo Belchiorinho. "Langmuir-Blodgett films as a model of the skin barrier lipids – corneocyte interface". Master, 2022. http://hdl.handle.net/10451/58051.
  3. Da Cunha Branco Dos Santos, Tânia. "Biophysical and biological properties of atypical sphingolipids : implications to physiology and pathophysiology". PhD, 2021. http://hdl.handle.net/10451/50380.
  4. Silva, Liana C. "Sphingosine-induced alterations in membrane biophysical properties: biological relevance in the pathophysiology of human disease". PhD, Universidade de Lisboa Faculdade de Farmácia, 2019. http://hdl.handle.net/10451/38762.
  5. Silva, Liana C. "Vaccine combined with PI3K inhibitor and OX40 against colorectal cancer (CRC)". Master, 2019.
  6. Carreira, Ana Cláudia Nunes. "Sphingosine-induced alterations in membrane biophysical properties: biological relevance in the pathophysiology of human disease". PhD, 2019. http://hdl.handle.net/10451/38762.
  7. Mateus, Mariana Soares. "Hybrid multimodal nanovaccine against colorectal cancer". Master, 2019. http://hdl.handle.net/10451/43202.
  8. Conniot, João Miguel de Oliveira, 1989-; Florindo, Helena Isabel Fialho, 1979-; Brocchini, Steve; Silva, Liana Casquinha da. "Multicomponente particulates for immune modulation". PhD, 2018. http://hdl.handle.net/10451/33135.
  9. Martinho, Nuno Filipe Rodrigues, 1989-; Silva, Liana Casquinha da; Brocchini, Steve; Zeoh, Mire. "Fluorescent-based dendrimers as potential drug delivery carriers of cisplatin : from design and synthesis to platinum-membrane interactions". PhD, 2018. http://hdl.handle.net/10451/35238.
  10. Sirage, Melissa Margarete Jessen; Ferreira, Hugo Alexandre; Silva, Liana C.. "Study of the interactions of surface-modified particles with membrane model systems". Master, 2016. http://hdl.handle.net/10451/26108.
  11. Varela, Ana Raquel Pinto, 1985-; Silva, Liana C.; Prieto, Manuel José Esteves, 1949-; Futerman, Anthony H.. "The link between altered glucosylceramide composition and membrane properties : from membrane biophysics to gaucher disease". PhD, 2015. http://hdl.handle.net/10451/22970.
  12. Silva, Liana C. "Immune system role on gaucher disease". Master, Universidade de Lisboa Faculdade de Farmácia, 2014. http://hdl.handle.net/10451/36736.
  13. Silva, Liana C. "Finding the biophysical mechanisms underlying the distinct biological actions of different ceramides". PhD, Universidade de Lisboa Instituto Superior Técnico, 2013.
  14. Silva, Liana C. "Nystatin and Ceramide Interaction with Multicomponent Model Membranes: Relating Membrane Biophysics with Antibiotic Action and Apoptosis". PhD, Universidade de Lisboa Instituto Superior Técnico, 2006.
Website
  1. Silva, Liana C; D'Angelo, Giovanni; Clarke, Christopher J.. Sphingolipid Biology Platform. 2020. https://www.sphingolipidbiology.com/.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/03 Fluorescence-based strategies to study lipid droplets properties 12th Workshop on Lipidomics: Lipidomics in Health and Disease
(Portugal)
2024 Cell lipid droplet heterogeneity and altered biophysical properties induced by cell stress and metabolic imbalance Department Seminar
J Heyrovsky Institute of Physical Chemistry, Czech Academy of Sciences (Prague, Czech Republic)
2023 Fluorescence-based strategies to study the biophysical properties of biological membranes and organelles 3rd Chem&BioChem Students Meeting
Faculdade de Ciências Universidade de Lisboa (Lisboa, Portugal)
2023 Interaction of the antifungal polyene Nystatin with sphingolipids: putative role in antifungal activity FEBS Special Meeting on Sphingolipid Biology: the dawn of a new era
(funchal, Portugal)
2022/03 Fluorescence Methods to Investigate the Biophysical Properties of Sphingolipids Gordon Research Conference on Glycolipid and Sphingolipid Biology
GRC (Il Ciocco, Italy)
2022/01 Fluorescence methodologies as a tool to investigate the organization and function of biological membranes Winter School on Membrane Biophysics: Impact of Lipids on Health, Disease and Therapy¿
(Porto, Portugal)
2019 Lipid domains in biological membranes Invited Seminar
Swiss Federal Institute of Technology Lausanne (EPFL) (Lausanne, Switzerland)
2019 Lipid domains and pathological disturbances of membrane dynamics Invited Keynote Lecture
TRR83 PhD/Postdoc meeting (Heidelberg, Germany)
2019 Biological and pathological implications of Glucosylceramide-enriched domains 25th International symposium on glycoconjugates
Milano (Milano, Italy)
2019 Lipid domains in biological membranes Invited Seminar
Universidade do Porto Faculdade de Farmácia (Porto, Portugal)
2019 The effect of Canonical canonical and 1-deoxy(methyl)sphingolipids sphingoid bases in membrane fluidity and lateral organization FEBS Special Meeting in Sphingolipid Biology: Sphingolipids in Physiology and Pathology
(Cascais, Portugal)
2018 Canonical versus Atypical Sphingolipids: do they behave the same? Gordon Research Conference on Glycolipid and Sphingolipid Biology
Galveston, Texas, USA (Texas, United States)
2018 The impact of atypical sphingolipids on the biophysical properties of model and cell membranes 6th International Iberian Biophysics Congress and X Iberoamerican Congress of Biophysics
(Castellón, Spain)
2018 The impact of atypical sphingolipids on the biophysical properties of model and cell membranes 10th iMed.ULisboa Postgraduate Students Meeting and 3rd i3DU Meeting
(Lisboa, Portugal)
2017 Lipid domains in biological membranes: from membrane lipid organization to membrane physiology CEDOC Seminars
Universidade Nova de Lisboa Faculdade de Ciências Médicas (Lisboa, Portugal)
2017 Development of lysosome-mimicking vesicles to study the effect of abnormal accumulation of sphingosine on membrane properties Sphingolipid Club Meeting
Trabia, Sicily, Italy (Sicily, Italy)
2017 Membrane biophysics: understanding the properties of SLs Sphingolipid Club Meeting
Trabia, Sicily, Italy (Sicily, Italy)
2017 Lipid domains in biological membranes Invited Seminar
Jaroslav Heyrovsky Institute of Physical Chemistry, Academy of Sciences of the Czech Republic (Prague, Czech Republic)
2017 Ceramide domains in living cell membranes: from biophysical characterization to biological significance XXV Encontro Nacional da SPQ
Lisboa (Lisboa, Portugal)
2017 Lipid domains in biological membranes Invited Seminar
Dept. Neuroscience and Pharmacology, Copenhagen University (Copenhagen, Denmark)
2017 Lipid domains in biological membranes 16th Congress of the Spanish Biophysics Society (SBE)
Seville (Seville, Spain)
2017 Ceramide Platforms: the interface between molecular biophysics and cell biology Molecular Pharmacology Program
Memorial Sloan Kettering Institute (New York, United States)
2017 Ceramide Platforms: the interface between molecular biophysics and cell biology UC Biotech, CNC
Universidade de Coimbra (Cantanhede, Portugal)
2017 Lipid-lipid and lipid-drug interactions in biological membranes Invited Seminar
Department of Medicine, Faculty of Health, University of Witten/Herdecke (Witten, Germany)
2017 Pathological levels of Glucosylceramide change the biophysical properties of artificial and cell membranes 9th International Ceramide Conference
Port Jefferson (New York, United States)
2016 Molecular interactions in biological membranes: understanding the role of lipid-lipid interplay in membrane organization and function UC-Symposium on Biomedicine of Sphingolipids
University of Cincinnati (Cincinnati, OH, United States)
2016 Cisplatin-induced changes on membrane biophysical properties of colon cancer cells: characterization of the initial steps of cisplatin mechanism of action 3rd Molecular Medicine of Sphingolipids International Conference
French Lick (Indiana, United States)
2016 A Three-Component Assembly Promoted by Boronic Acids Delivers a Modular Fluorophore Platform (BASHY Dyes) 8th Postgraduate iMed.ULisboa Students Meeting
(Lisboa, Portugal)
2016 Ceramide-gel domains in living cells: understanding the role of membrane biophysical properties in cell (patho)physiology 5th Iberian Biophysics Congress
(Porto, Portugal)
2016 Development of polymeric vaccine delivery nanosystems for HIV/AIDS control through dendritic cell modulation XI Spanish-Portuguese Conference on Controlled Drug Delivery - Revolutionary Approaches in Nanomedicine Development
(Granada, Spain)
2016 PEG-modified PLA nanoparticles for site-specific functionalization XI Spanish-Portuguese Conference on Controlled Drug Delivery, "Revolutionary Approaches in Nanomedicine Development”
(Granada, Spain)
2015 Ceramide-platforms: the interface between molecular biophysics and cell biology Invited Seminar
Cancer Institute, University of Cincinnati (Cincinnati, OH, United States)
2015 Lipid-lipid and lipid-drug interplay in biological membranes: from membrane lipid organization to membrane physiology 7th Postgraduate iMed.ULisboa Students Meeting
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2015 Tackling the biophysical properties of sphingolipids to decipher their biological roles iMed.ULisboa Seminars
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2015 Unraveling the biophysical properties of sphingolipids: from model to cell membranes International Ceramide Conference
(Izmir, Turkey)
2015 Ceramide-platforms: the interface between molecular biophysics and cell biology LIMES
University of Bonn (Bonn, Germany)
2015 The effect of sphingosine on the biophysical properties and permeability of raft mimicking mixtures 7th Postgraduate iMed.ULisboa Students Meeting
(Lisboa, Portugal)
2015 Ceramide-induced biophysical alterations in membranes of live cells International Ceramide Conference
(Izmir, Turkey)
2015 Activation of TNF receptor leads to ceramide-gel domain formation in endocytic vesicles WE- Heraeus Seminar: Advanced Microscopy of Membrane Biophysics
(Bad Honnef, Germany)
2014 Tackling sphingolipids’ biophysical properties to decipher their biological roles Symposium Sphingolipids in Health and Disease
(Porto, Portugal)
2014 Lipid-lipid and lipid-drug interplay in biological membranes: from membrane lipid organization to membrane physiology Invited Seminar
Université Catholique de Louvain & Louvain Drug Research Institute (Brussels, Belgium)
2014 Imaging Ceramide platforms in model and cell membranes EMBO Workshop on “Lipid Imaging”
(Naples, Italy)
2014 Ceramide-platforms: the interface between molecular biophysics and cell biology Invited Seminar
Faculty of Sciences, University of Geneva (Geneva, Switzerland)
2014 Insights into the biophysics underlying lipid interactions in nanoliposomes: clues from fluorescence spectroscopy, confocal and two-photon microscopy 1st International Symposium on Nanoparticles/Nanomaterials and Applications
(Costa da Caparica, Portugal)
2014 Characterization of ceramide-induced changes on the biophysical properties of cellular membranes 2nd International Workshop on Molecular Medicine of Sphingolipids
(Kloster Benz, Germany)
2014 Ceramide-platforms@the endolysosomal pathway: a novel mechanism by which ceramide activates intracellular targets? International Conference on the Bioscience of Lipids
(Aberdeen, United Kingdom)
2014 Ceramide-platforms@the endo/lysosomal pathway: a novel mechanism by which ceramide activates intracellular targets? Gordon Research Conference on Glycolipid and Sphingolipid Biology
(Ventura, California, United States)
2013 Ceramide and Glucosylceramide impact on membrane biophysical properties: from model to cell membranes, Plenary Lecture XLII Annual Meeting Argentinian Biophysical Society
(Cordoba, Argentina)
2013 Development of dendritic cell-targeted peptide vaccine against melanoma by multifunctional nanoparticles 1st International Symposium on Profiling
(Costa da Caparica, Portugal)
2013 Biomembranes: the interface between molecular biophysics and cell biology Invited Seminar
Gulbenkian Institute of Science (Lisboa, Portugal)
2013 Glucosylceramide as a signaling lipid: link between unbalanced metabolism, membrane properties and development of Gaucher Disease 7th International Ceramide Conference
Montauk (New York, United States)
2013 Ceramide C24:0 sharply changes membrane organization and morphology 5th Post-graduate iMed.UL Students Meeting
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2013 Ceramide activates endocytosis and forms ordered intracellular lipid domains in response to TNF-a 9th European Biophysics Congress
(Lisboa, Portugal)
2012 Membrane domains, lipid phase diagrams, rafts and ceramides: advanced fluorescence methodologies in membrane biophysics, Opening Plenary Lecture Strasbourg Workshop on Membrane Biophysics
(Strasbourg, France)
2012 Fluorescence and microscopy in membrane biophysics: rafts, ceramides, amyloids and lipid-protein interaction, Opening Plenary Lecture XV International Symposium on Luminescence Spectrometry
(Barcelona, Spain)
2012 Ceramide platforms and microdomains function Gordon Research Conference on Glycolipid and Sphingolipid Biology
(Il Cioco in Lucca, Italy)
2011 From lipid to disease – the relevance of glycosphingolipid composition and membrane properties 3rd Post-graduate iMed.UL Students Meeting
Universidade de Lisboa Faculdade de Farmácia (Lisboa, Portugal)
2011 From membrane biophysics to Gaucher disease: the link between altered glucosylceramide composition and membrane properties FEBS Workshop “Cell Biology and Pharmacology of Mendelian Disorders”
(Naples, Italy)
2010 Rafts and Ceramides: biophysical perspective of biologically relevant membrane domains 51st International Conference on the Bioscience of Lipids
(Bilbao, Spain)
2010 Ceramides, rafts and their interplay: Biophysical perspectives International Courses on Toxicology
Center for Neurosciences and Cell Biology (Coimbra, Portugal)
2010 Biophysics of ceramides and complex sphingolipids Gordon Research Conference on Glycolipid and Sphingolipid Biology
(Ventura (CA), United States)
2010 Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations International Student Workshop on Lipid Domains
Weizmann Institute of Science (Rehovot, Israel)
2010 Ceramide Gel Domain Formation in a Phospholipid Bilayer: The Impact of Ceramide Acyl Chain International Student Workshop on Lipid Domains
Weizmann Institute of Science (Rehovot, Israel)
2010 Cholesterol-Rich Fluid Membranes Solubilize Ceramide Gel Domains. Implications for the Organization of Mammalian Membranes International Student Workshop on Lipid Domains
Weizmann Institute of Science (Rehovot, Israel)
2010 Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations 54th Biophysical Society Annual Meeting
(San Francisco, California, United States)
2010 Cholesterol-Rich Fluid Membranes Solubilize Ceramide Gel Domains. Implications for the Organization of Mammalian Membranes 54th Biophysical Society Annual Meeting
(San Francisco, California, United States)
2010 A critical role for Ceramide Synthase 2 , Gordon Research Conference on Glycolipid and Sphingolipid Biology
(Ventura, California, United States)
2009 Rafts, ceramides, and fluid lipids: Phase diagrams determination from photophysical methodologies International Conference of Fluorescence in Biology
(Mumbai, India)
2009 Fluorescence techniques as tools to characterize lipid-lipid and lipid-drug interactions in nanoliposomes 2nd ESF/UB European Summer School on Nanomedicine
(Lisboa, Portugal)
2009 Sphingomyelinase activity and Ceramide-induced membrane physical alterations are strongly dependent on lipid raft composition 5th Charleston Ceramide Conference
(Charleston, United States)
2008 Biophysics of rafts and their interplay with ceramides 49th International Conference on the Bioscience of Lipids
(Maastricht, Netherlands)
2008 Ceramide, sphingomyelin and unsaturated lipids in the absence of cholesterol: Phase diagrams, gel phases and their biological relevance 1st Portuguese-Spanish-British Joint Biophysical Congress
(Lisboa, Portugal)
2008 Lipid raft composition modulates sphingomyelinase activity and ceramide-induced membrane physical alterations FEBS Workshop – Lipids as regulators of cell function
(Spetses, Greece)
2008 Glucosylceramide and Ceramide induce similar alterations in membrane biophysical properties Gordon Research Conference on Glycolipid and Sphingolipid Biology
(Il Cioco in Lucca, Italy)
2007 Modulation of lateral membrane organization by the interplay of ceramide with lipid rafts 6th European Biophysics Congress
(London, United Kingdom)
2007 Ceramide recruits 3 sphingomyelin molecules to form nanometer-sized gel domains that are destroyed by cholesterol in lipid rafts 51st Biophysical Society Annual Meeting
(Baltimore, United States)
2006 Sphingomyelin/cholesterol-rafts and ceramide-platforms: biophysical perspectives COST Action D22 “Lipid-Protein Interactions” Managing Committee Meeting
(Murcia, Spain)
2006 Ceramide-domain formation and collapse in lipid rafts: membrane reorganization by an apoptotic lipid. Comparison to ganglioside GM1 The second ISN special Neurochemistry conference: Neural glycoproteins and glycolipids
(Antigua and Barbuda)
2005 Biophysical properties of Ceramide-containing lipid bilayers using fluorescence methodologies Workshop COST D22: Membrane Domains and Lipid Asymmetry
(Utrecht, Netherlands)
2005 Ganglioside and ceramide: two lipids involved in cell signalling with opposite raft-related behaviour FEBS Advanced Course “Lipid-protein interaction in signalling and membrane traffic”
(Santa Maria Imbaro (CH), Italy)
2002 The role of sterols in the mechanism of aggregate formation by the polyene antibiotic nystatin COST Action D22: 1st ‘Domain’ Working Group Meeting on “Membrane Domains and Rafts”
(Segóvia, Spain)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024 - Current Lipid Alterations in Neurodegenerative Diseases: From Pathogenesis to Potential Therapies
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - Current Lipid Alterations in Alzheimer's Disease: From Pathogenesis to Potential Therapies
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - Current Lysosomal Dysfunction: A Key Link to Understanding Parkinson's Disease Pathogenesis
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - Current Nystatin: Pioneering the Future of Antifungal Strategies in Combatting Infections
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - Current Nystatin: Pioneering the Future of Antifungal Strategies in Combatting Infections
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2024 - Current Deciphering Lipid Droplets Biophysical Properties
Supervisor
Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2022 - Current Langmuir-Blodgett films as a model of the skin barrier lipids - corneocyte interface
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - Current Role of sialylation in Brugada Syndrome Pathogenesis
Co-supervisor
Università Vita Salute San Raffaele, Italy
2021 - Current Lysosomal disfunction and Parkinson’s disease
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - Current Emerging roles of Lipid Droplets in Lysosomal Storage Diseases
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - Current Gaucher disease and Parkinson's disease: identifying the mechanisms underlying two unrelated diseases
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - Current Implication of stress stimuli-derived ceramides on cell membrane biophysical properties: understanding the molecular mechanisms of ceramides action
Supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Current Drug-membrane interactions - a focus on nystatin and a novel budesonide-cyclodextrin complex
Co-supervisor
Université catholique de Louvain, Belgium
2015 - 2021 Biological and biophysical properties of atypical sphingolipids: implications to physiology and pathophysiology.
Supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Vaccine combined with PI3K inhibitor and OX40 against colorectal cancer (CRC)
Co-supervisor
 Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Canonical versus atypical sphingolipids: do they behave the same?
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Understanding the action of nystatin: studies with liposomes as membrane models and drug delivery systems
Co-supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 - 2019 Sphingosine-induced alterations in membrane biophysical properties: biological relevance in the pathophysiology of human disease
Supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2018 Implication of stress stimuli-derived ceramides on cell membrane on cell membrane biophysical properties: understanding the molecular mechanisms of ceramide action
Supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018 Biophysical properties of sphingolipids and their implication in membrane structure
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2018 Multicomponente particulates for immune modulation
Co-supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2018 Fluorescent-based dendrimers as potential drug delivery carriers of cisplatin : from design and synthesis to platinum-membrane interactions
Supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2017 Biological and biophysical properties of atypical sphingolipids: implications to physiology and pathophysiology
Supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2016 Study of the interactions of surface-modified particles with membrane model systems
Supervisor
 Engenharia Biomédica e Biofísica (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011 - 2015 The link between altered glucosylceramide composition and membrane properties : from membrane biophysics to gaucher disease
Supervisor
 Pharmacy (pharmaceutical technology) (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 Fluorescent-based dendrimers as potential drug delivery carriers of cisplatin: form design and synthesis to platinum-membrane interactions Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 Sphingosine-induced alterations in membrane biophysical properties: biological relevance in the pathophysiology of human disease Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014 Immune system role on gaucher disease
Supervisor
 Ciências Farmacêuticas (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014 Understanding Nystatin molecular mechanism of action as a tool to develop improved lipid-based delivery systems
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013 Implication of ceramide acyl chain structure on membrane biophysical properties
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013 Molecular biophysics as a tool to develop improved lipid-based Nystatin-delivery systems
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2013 Design of particulate carriers for the delivery of cancer antigens to dendritic cells
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2009 - 2013 Finding the biophysical mechanisms underlying the distinct biological actions of different ceramides.
Co-supervisor
 Química (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012 - 2012 The link between altered glucosylceramide composition and membrane properties: from membrane biophysics to Gaucher Disease
Supervisor
 Farmácia (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/04/20 - Current Webinar Series on Sphingolipids Biology: Sphingolipids in Physiology and Pathology https://www.sphingolipidbiology.com/ (2020/04/20)
Seminar (Co-organisor)
2023/10/08 - 2023/10/13 FEBS Special Meeting on Sphingolipid Biology: the dawn of a new era https://sphingolipidbiology2023.febsevents.org/ (2023/10/08 - 2023/10/13)
Conference (President of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/04/19 - 2021/04/22 International Ceramide Conference https://www.sphingolipidbiology.com/icc (2021/04/19)
Conference (Member of the Organising Committee)
2019/05/06 - 2019/05/10 FEBS Special Meeting in Sphingolipid Biology: Sphingolipids in Physiology and Pathology https://sphingolipidbiology2019.febsevents.org/ (2019/05/06)
Conference (President of the Organising Committee)
2016 - 2016 Martin Hof, Institute of Physical Chemistry, Academy of Sciences, Czech Republic, “Does Ganglioside GM1 promote neurodegeneration or does it act neuroprotective? Molecular insights by single molecule fluorescence”, (2016)
Seminar (Co-organisor)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2016 Biophysical Characterization Symposium in the framework of the Advanced Drug Delivery Course, i3DU PhD Programme (2016)
Symposium (Co-organisor)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2015 Giovanni D’Angelo, Institute of Protein Biochemistry, National Research Council of Italy, Italy, “Epigenetic control of glycosphingolipid metabolic switch” (2015)
Seminar (Co-organisor)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - 2015 Tony Futerman, Weizmann Institute of Science, Israel, “Sphingolipids in health and disease" (2015)
Seminar (Co-organisor)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2014 John Hazin, German Cancer Research Center, Germany, “Galectin-3 induces clustering and domain formation of L1CAM on the cell surface of human cancer cell lines” (2014)
Seminar (Co-organisor)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2012 Steve Brochinni, University College London, UK (2012)
Seminar (Co-organisor)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2012 - 2012 Mire Zloh, University College London (2012)
Seminar (Co-organisor)
 Universidade de Lisboa Faculdade de Farmácia, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/02 - 2024/02 Co-chair of the GRC session on "Analysis of Sphingolipids and Glycosphingolipids"
Conference
 Gordon Research Conference on Glycolipid and Sphingolipid Biology
2021/04/19 - 2022/04/22 Co-chair of the session "Novel Tools, Structure & Biophysics"
Conference
 11th International Ceramide Conference
2016 - 2016 Discussion Leader of the GRC session "Enzymology and Regulation of Glycolipids and Sphingolipids"
Conference
 Gordon Research Conference on Glycolipid and Sphingolipid Biology
2013 - 2013 Chair of the session "Lipid Trafficking and Membrane Biophysics"
Conference
 7th International Ceramide Conference

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024 Exploring plasma membrane heterogeneity in saccharomyces cerevisiae with a focus on sphingolipid hydroxylation
(Thesis) Main arguer
 Helena Monteirinho Leitão (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2023 Interaction of the LC3/GABARAP autophagy proteins with membranes: Exploring the effects of ceramide
(Thesis) Main arguer
 Yaiza Varela Fernández (PhD)
Universidad del País Vasco Facultad de Ciencia y Tecnología, Spain
2023 Evidence and role for plasma membrane lipid domains in the spatial control of myoblast migration
(Thesis) Arguer
 Juliette Vanderroost (PhD)
Institut de Duve, Belgium
2023 Exploring the biophysical properties of biological membranes: from ceramide domains to lipid droplets
Supervisor
 Ana Ester Ventura (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 Deep Learning-Based Microscopy Fluorescence Images Segmentation and Analysis: Development of an AI-tool for Cell and Lysosome Segmentation and Analysis
(Thesis) Main arguer
 Bruna Ferreira Silva (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023 Lipid alterations in Parkinson’s disease
Supervisor
 Laura Preciado (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 Sphingolipid domains in the plasma membrane of fungal cells: Interplay with membrane proteins and antifungal resistance
(Thesis) Main arguer
 Filipa Pedro Costa Santos (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022 Novas terapêuticas para medicina de precisão em oncologia
(Thesis) Main arguer
 Mariana Alves Mimoso (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 Nanotechnology for lung cancer therapy
(Thesis) Main arguer
 João Paulo Teixeira Pereira (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 Deciphering melanoma stroma to improve immunotherapy efficacy
(Thesis) Main arguer
 Jéssica César Luís (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 Estudo das interacções moleculares e do modo de acção da nistatina em sistemas modelo de membranas biológicas
(Thesis) Main arguer
 Mafalda Guimarães (Other)
Universidade de Lisboa Faculdade de Ciências, Portugal
2022 Langmuir-Blodgett films as a model of the skin barrier lipids - corneocyte interface
Supervisor
 Bárbara Bernardino (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 Gaucher disease and Parkinson’s disease: identifying the mechanisms underlying two unrelated diseases
Supervisor
 Duarte Miguel Riachos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 Biophysical properties of sphingolipid-deficient cell membranes
(Thesis) Main arguer
 Bingen Gutiérrez Monasterio (PhD)
Universidad del País Vasco, Spain
2021 Role of cholesteryl-hemiesters in the etiology of Atherogenesis
(Thesis) Main arguer
 Liliana Teresa da Silva Alves (PhD)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021 Biophysical properties of sphingolipid-deficient cell membranes
(Thesis) Main arguer
 Bingen Gutiérrez Monasterio (PhD)
Universidad del País Vasco, Spain
2021 Role of cholesteryl-hemiesters in the etiology of Atherogenesis
(Thesis) Main arguer
 Liliana Teresa da Silva Alves (PhD)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2021 Biophysical and biological properties of atypical sphingolipids: implications to physiology and pathophysiology
Supervisor
 Tânia Santos (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 Sphingosine-induced alterations in membrane biophysical properties: biological relevance in the pathophysiology of human disease
Supervisor
 Ana C Carreira (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 In vitro and in vivo studies of proatherogenic effects induced by end-products of cholesteryl esters oxidation
(Thesis) Main arguer
 Neuza Domingues (PhD)
Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal
2018 Fluorescent-based dendrimers as potential drug delivery carriers of cisplatin: from design and synthesis to platinum-membrane interactions
Supervisor
 Nuno Martinho (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Control of neuronal signalling pathways by CYP46A1, an enzime involved in brain cholesterol homeostasis
(Thesis) Arguer
 Moutinho, Miguel Alves da Silva de Carvalho (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Control of neuronal signalling pathways by cyp46a1, an enzyme involved in brain cholesterol homeostasis
(Thesis) Main arguer
 Miguel Moutinho (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 Lateral organization of PI(4,5)P2 in model membranes and at the plasma membrane of living cells
(Thesis) Main arguer
 Maria João Sarmento (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016 Study of the Interactions of Surface-Modified Particles with Membrane Model Systems
Supervisor
 Melissa Sirage (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2015 Novas abrodagens para estimulação de células dendríticas : aplicações antitumorais
(Thesis) Main arguer
 Garcia, Catarina Alexandra Gonçalves (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 The link between altered glucosylceramide composition and membrane properties: From membrane biophysics to Gaucher Disease
Supervisor
 Ana Raquel Varela (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 Lipid alterations in Farber Disease
(Thesis) Main arguer
 Natália Santos Ferreira (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2014 Development of a Micropatterned System to Study the Role of Protein Tethers in Lipid Membrane Organization
(Thesis) Main arguer
 Samuel Lourenço Jacob (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014 Development of nanosystems for HIV vaccine delivery
(Thesis) Main arguer
 Ana Isabel Matos (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2014 lntracellularly-targeted nanoplatform to target dendritic cells and for immunomodulation
President of the jury
 Carina S.G. Peres (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 Dendrimer Antigens as cancer immunotherapeutics
Supervisor
 Vanessa Gameiro Sainz (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 Finding the biophysical mechanisms underlying the action of Ceramide with distinct N-acyl chain structures: from model to cell membranes
Supervisor
 Sandra Pinto (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013 Interaction of apoptotic and cytoprotective bile acids with biomembranes and apoptotic protein BAX
(Thesis) Main arguer
 Tânia Sousa (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2013 Immune system role on Gaucher Disease
Supervisor
 André Duarte (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2011 Effect of palmitoylated synaptic proteins and biologically relevant calcium concentrations on the compartmentalization of PI(4,5)P2 in membrane model systems and in the plasma membrane of PC12 cells
(Thesis) Main arguer
 Maria João Sarmento (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 Estudos Biofísicos em Sistemas Modelo da Membrana Plasmática da Levedura
(Thesis) Main arguer
 André M.H. Cordeiro (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal
2009 Caracterização Biofísica da Membrana Plasmática da Levedura
(Thesis) Main arguer
 Francisco M.M.S.A. Branco (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Committee member

Activity description
Role 		Institution / Organization
2022 - Current Secretary of the general assembly of SPCF (Portuguese Society of Pharmaceutical Sciences
Other
2018 - Current Scientific board of Sphingolipid Club
Other

Consulting

Activity description Institution / Organization
2018 - Current consultant in GenoMed in the framework of the project LysoMod: Genetic and Small Molecule Modifiers of Lysosomal Function (H2020-MSCA-RISE-2016)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2022 - Current Biochemistry I Ciências Farmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09 - Current Physics Ciências Farmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 - Current Cell Biology Pharmaceutical Sciences (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Pharmaceutical Biophysics Pharmaceutical Biophysics (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2019 Workshop in "Imaging tools in biomarker discovery" - PhD course Biomarker and Assay Development i3DU PhD course (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Faculdade de Farmácia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2021 - Current Cells MDPI
2020 - Current All Life Taylor & Francis Publishing Group
2019 - Current Frontiers in Molecular Biosciences
2018 - Current Scientific Reports Nature Publishing Group
2018 - Current Frontiers in Physiology

Mentoring / Tutoring

Topic Student name
2022 - Current Exploring the biophysical link between Gaucher disease and Parkinson's disease Pedro Matos
2017 - 2022 Role of membrane biophysical properties in the pathophysiology of Gaucher Disease Sarka Pokorna (postdoc)
2019 - 2021 Exploring the biophysical link between Gaucher disease and Parkinson's disease Carla Sousa (Postdoc)
2019 - 2019 Biophysical and Biological properties of atypical sphingolipids Beatriz Mestre
2016 - 2017 Biophysical and Biological properties of atypical sphingolipids Patricia Bastião
2014 - 2015 Ceramide-platforms: biophysical properties & biological implications Ana Ester Ventura
2014 - 2015 Ceramide-platforms: biophysical properties & biological implications Tânia Cunha Santos
2014 - 2014 Implications of Glucosylceramide and ceramide on membrane biophysical properties Ana Ester Ventura
2014 - 2014 Implications of Glucosylceramide and ceramide on membrane biophysical properties André Sá Couto
2012 - 2014 Implications of Glucosylceramide and ceramide on membrane biophysical properties Andreia Giro dos Santos
2011 - 2014 Nanoparticulate systems for cytosolic delivery of combined drug-siRNA for breast cancer therapy. Ana Isabel Saraiva (postdoc)
2011 - 2012 Implications of Glucosylceramide and ceramide on membrane biophysical properties Eva Zupancic
2007 - 2008 Sandra Cristina Nunes Trigo Pinto
2006 - 2007 Bruno Miguel Mota Castro
Distinctions

Other distinction

2014 Investigator FCT 2014 (IF/00437/2014)
Fundação para a Ciência e a Tecnologia, Portugal
2008 FEBS youth travel award
2008 Ciência 2008 Assistant Researcher
Fundação para a Ciência e a Tecnologia, Portugal
2006 Student Travel Award
2006 Post-Doctoral Fellowship, PIDDAC SFRH/BPD/30289/2006
Fundação para a Ciência e a Tecnologia, Portugal
2006 Conference Young Investigator Fellowship
2005 FEBS Fellowship Winner (for FEBS Forum for Young Scientist and Congress)
2003 PhD fellowship SFRH/BD/10029/2002
Fundação para a Ciência e a Tecnologia, Portugal