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Zita Carvalho dos Santos. Completed the Doutoramento in Biologia in 2010 by Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica and Licenciatura in Licenciatura em Biologia Microbiana e Genética in 2005 by Universidade de Lisboa Faculdade de Ciências. Is Contracted Researcher in Programa Champalimaud de Neurociências. Published 9 articles in journals. Organized 3 event(s). Participated in 7 event(s). Co-supervised 1 PhD thesis(es). Co-supervised 1 MSc dissertation(s). Has received 15 awards and/or honors. Participates and/or participated as PhD Student Fellow in 1 project(s), Post-doc in 1 project(s), Post-doc Fellow in 1 project(s) and Principal investigator in 1 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Behavioural Sciences Biology, Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology and Natural sciences with emphasis on Biological Sciences with emphasis on Reproductive Biology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Drosophila; feeding; behaviour; metabolism; PPP; Domínio/Área Científica::Engenharia e Tecnologia::Engenharia Química; .
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Identification

Personal identification

Full name
Zita Carvalho dos Santos
Date of birth
1984/03/25
Gender
Female

Citation names

  • Carvalho-Santos, Zita

Author identifiers

Ciência ID
DB1A-9A10-5C0F
ORCID iD
0000-0001-7100-308X

Email addresses

  • zita.santos@medicina.ulisboa.pt (Professional)

Addresses

  • Instituto de Medicina Molecular João Lobo Antunes Edifício Egas Moniz Avenida Professor Egas Moniz, 1649-028, Lisbon, Lisbon, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Behavioural Sciences Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Reproductive Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2006 - 2010
Concluded
 Biologia (Doutoramento)
Major in Especialidade: Biologia Celular
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
"Evolution and Biogenesis of Microtubule-derived Structures" (THESIS/DISSERTATION)
 Aprovado por unanimidade
2005
Concluded
 Licenciatura em Biologia Microbiana e Genética (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
 16
2001
Concluded
 n/a (Ensino secundário)
Escola Secundária de Porto de Mós, Portugal
"n/a" (THESIS/DISSERTATION)
 18
Affiliation

Science

Category
Host institution 		Employer
2023/01 - Current Principal Investigator (Research) Universidade de Lisboa Instituto de Medicina Molecular, Portugal
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2019/01 - 2022/12 Contracted Researcher (Research) Programa Champalimaud de Neurociências, Portugal
2012 - 2018/12 Postdoc (Research) Programa Champalimaud de Neurociências, Portugal
2010 - 2012 Postdoc (Research) Instituto Gulbenkian de Ciência, Portugal
2005 - 2006 Research Trainee (Research) Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Projects

Grant

Designation Funders
2023/01/01 - Current The impact of germline metabolic reprogramming on reproduction and physiology
101043068 - SweetEggs
Principal investigator
European Research Council, Belgium
 European Research Council
Ongoing
2022/06/01 - Current The role of healthy cells on the elimination of premalignant cells
PTDC/BIA-CEL/3594/2020
Co-Principal Investigator (Co-PI)
Fundação Champalimaud, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/08/01 - Current Metabolic reprogramming, dietary nutrients and food cravings in ovary aging
#GCRLE-1420
Co-Principal Investigator (Co-PI)
Fundação Champalimaud, Portugal
 Global Consortium for Reproductive Longevity and Equality, Buck Institute for Research on Aging
Ongoing
2023/12/14 - 2025/12/13 Sub-cellular Metabolic Compartmentalization during Oocyte Development
2023-331947
Principal investigator
Ongoing

Contract

Designation Funders
2023/01/07 - Current The impact of germline cellular metabolism on reproduction and physiology
CEECINST/00021/2021
Principal investigator
Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2019/01/01 - 2023/01/06 Interaction of organ systems in nutritional decision making
FCT - Norma Transitória DL 57/2016
Post-doc

Other

Designation Funders
2018 - 2021 Microbiome, nutrients and the brain: Identifying the molecular programs underlying the impact of essential amino acids and the microbiome on brain function.
FCT-PTDC/BIA-MOL/30081
Post-doc Fellow
2012/01 - 2018/12/31 Interaction of organ system in nutritional decision making
SFRH/BPD/76201/2011
Post-doc Fellow
Fundo Regional para a Ciência e Tecnologia
2006/09/01 - 2010/10/01 Evolution and biogenesis of microtubule-based structures.
SFRH/BD/30760/2006
PhD Student Fellow
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference poster
  1. Carvalho-Santos, Zita; de Haan Vicente, Inês; Cardoso-Figueiredo, Rita; Tastekin, Ibrahim; Ribeiro, Carlos. Corresponding author: Carvalho-Santos, Zita. "How cellular metabolic reprogramming shapes nutrient utilization by the germline and impacts female fertility". Paper presented in FASEB, The Reproductive Aging Conference, 2022.
  2. Carvalho-Santos, Zita; Carlos Ribeiro. "The metabolic program of proliferating cells controls sugar cravings". Paper presented in Annual Portuguese Drosophila Meeting, 2018.
  3. Carvalho-Santos, Zita; Carlos Ribeiro. "Sugar appetite is controlled by the metabolic program of germline cells". Paper presented in FENS Kalvi Network of Excellence Winter Symposium, 2017.
  4. Carvalho-Santos, Zita; Carlos Ribeiro. "Sugar appetite is controlled by the metabolic program of germline cells.". Paper presented in Champalimaud Research Symposium, 2017.
  5. Carvalho-Santos, Zita; Ana Patrícia Francisco; Ricardo Leitão-Gonçalves; Carlos Ribeiro. "Commensal bacteria and essential amino acids control food choice behavior and reproduction.". Paper presented in Champalimaud Research Symposium, 2016.
  6. Carvalho-Santos, Zita; Pedro Machado; Pedro Branco; José Pereira Leal; Mónica Bettencourt-Dias. "Molecular control of the basal body to axoneme transition.". Paper presented in Current Trends in Medicine Workshop: The centrosome: structure, function and dynamics, 2010.
  7. Carvalho-Santos, Zita; José Pereira Leal; Mónica Bettencourt-Dias. "What Does Evolution Tell Us About Centriole Duplication?". Paper presented in Annual Meeting of the American Society for Cell Biology, 2008.
  8. Carvalho-Santos, Zita; José Pereira Leal; Mónica Bettencourt-Dias. "What Does Evolution Tell Us About Centriole Duplication?". Paper presented in First EMBO Conference on Centrosomes and Spindle Pole Bodies, 2008.
  9. Carvalho-Santos, Zita; José Pereira Leal; Mónica Bettencourt-Dias. "What Does Evolution Tell Us About Centriole Duplication?". Paper presented in FASEB Summer Research Conferences, 2007.
Journal article
  1. Carvalho-Santos, Zita; Ribeiro, Carlos. "Do flies dream of protein? How the gut regulates sleep depth". Cell Metabolism 35 5 (2023): 732-734. http://dx.doi.org/10.1016/j.cmet.2023.04.001.
    10.1016/j.cmet.2023.04.001
  2. Li, Hongjie; Janssens, Jasper; De Waegeneer, Maxime; Kolluru, Sai Saroja; Davie, Kristofer; Gardeux, Vincent; Saelens, Wouter; et al. "Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly". Science 375 6584 (2022): http://dx.doi.org/10.1126/science.abk2432.
    10.1126/science.abk2432
  3. Lee S; Chen YC; FCA Consortium; Gillen AE; Taliaferro JM; Deplancke B; Li H; Lai EC. "Diverse cell-specific patterns of alternative polyadenylation in Drosophila.". Nature Communications (2022):
    Accepted
  4. Carvalho-Santos, Zita; Cardoso-Figueiredo, Rita; Elias, Ana Paula; Tastekin, Ibrahim; Baltazar, Célia; Ribeiro, Carlos. "Cellular metabolic reprogramming controls sugar appetite in Drosophila". Nature Metabolism 2 9 (2020): 958-973. http://dx.doi.org/10.1038/s42255-020-0266-x.
    10.1038/s42255-020-0266-x
  5. Henriques, Sílvia F.; Dhakan, Darshan B.; Serra, Lúcia; Francisco, Ana Patrícia; Carvalho-Santos, Zita; Baltazar, Célia; Elias, Ana Paula; et al. "Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-18049-9.
    10.1038/s41467-020-18049-9
  6. Ito, Daisuke; Zitouni, Sihem; Jana, Swadhin Chandra; Duarte, Paulo; Surkont, Jaroslaw; Carvalho-Santos, Zita; Pereira-Leal, José B; Ferreira, Miguel Godinho; Bettencourt-Dias, Mónica. "Pericentrin-mediated SAS-6 recruitment promotes centriole assembly". eLife 8 (2019): http://dx.doi.org/10.7554/elife.41418.
    10.7554/elife.41418
  7. Ricardo Leitão-Gonçalves; Zita Carvalho-Santos; Ana Patrícia Francisco; Gabriela Tondolo Fioreze; Margarida Anjos; Célia Baltazar; Ana Paula Elias; et al. "Commensal bacteria and essential amino acids control food choice behavior and reproduction". PLOS Biology 15 4 (2017): e2000862-e2000862. https://doi.org/10.1371%2Fjournal.pbio.2000862.
    10.1371/journal.pbio.2000862
  8. Carvalho-Santos, Z.; Ribeiro, C.. "Gonadal ecdysone titers are modulated by protein availability but do not impact protein appetite". Journal of Insect Physiology (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85028622095&partnerID=MN8TOARS.
    10.1016/j.jinsphys.2017.08.006
  9. Carvalho-Santos, Z.; Machado, P.; Alvarez-Martins, I.; Gouveia, S.; Jana, S.; Duarte, P.; Amado, T.; et al. "BLD10/CEP135 Is a Microtubule-Associated Protein that Controls the Formation of the Flagellum Central Microtubule Pair". Developmental Cell 23 2 (2012): 412-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-84865103367&partnerID=MN8TOARS.
    10.1016/j.devcel.2012.06.001
  10. Carvalho-Santos, Z.; Azimzadeh, J.; Pereira-Leal, J.B.; Bettencourt-Dias, M.. "Tracing the origins of centrioles, cilia, and flagella". Journal of Cell Biology 194 2 (2011): 165-175. http://www.scopus.com/inward/record.url?eid=2-s2.0-79961111227&partnerID=MN8TOARS.
    10.1083/jcb.201011152
  11. Carvalho-Santos, Z.; Machado, P.; Branco, P.; Tavares-Cadete, F.; Rodrigues-Martins, A.; Pereira-Leal, J.B.; Bettencourt-Dias, M.. "Stepwise evolution of the centriole-assembly pathway". Journal of Cell Science 123 9 (2010): 1414-1426. http://www.scopus.com/inward/record.url?eid=2-s2.0-77951758755&partnerID=MN8TOARS.
    10.1242/jcs.064931
  12. Bettencourt-Dias, M.; Carvalho-Santos, Z.. "Double life of centrioles: CP110 in the spotlight". Trends in Cell Biology 18 1 (2008): 8-11. http://www.scopus.com/inward/record.url?eid=2-s2.0-37849033589&partnerID=MN8TOARS.
    10.1016/j.tcb.2007.11.002
Thesis / Dissertation
  1. Figueiredo, Rita Cardoso. "Impact of the metabolic program of germline cells on feeding behaviour". Master, 2018. http://hdl.handle.net/10362/56822.
  2. Carvalho-Santos, Zita. "Evolution and biogenesis of microtubule-derived structures". PhD, 2010. http://hdl.handle.net/10362/5154.

Artistic / Performance

Theatre play
  1. 2022. European Researcher's Night, Stand-up Comedy.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/04 Metabolic Tango: Gut Bacteria and Dietary Nutrients Dance Together to Regulate Host Food Choices and Reproduction Fall ABC-RI International Forum and the Spring ABC-RI International Forum (Virtual)
(Portugal)
2023/02/05 Metabolic remodeling as a trigger for female fertility decay GCRLE Scholar Symposium
Buck Institute (San Francisco, United States)
2023/02/02 How germline cellular metabolic reprogramming impacts female fertility and whole animal physiology Building Bridges in Biology
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2022/01/27 How cellular metabolic programs affect whole animal physiology: Lessons from the germline Janelia Group Leader in 4DCP Interview Symposium
HHMI Janelia Research Campus (Ashburn, United States)
2021/11 Mapping Metabolic Programs in a Whole Animal at Single-Cell Resolution Annual Portuguese Drosophila Meeting
(Virtual, Portugal)
2021/06/24 Metabolic regulation of reproduction: from egg production to inter-organ communication Job Interview for Tenure Track Assistant Professor
Université de Lausanne - Suisse - UNIL (Lausanne, Switzerland)
2021/04 Making sweet eggs with flies. Making Reproductive Longevity a Reality webinar Series, Virtual.
National Institute of Aging with the Global Consortium for Reproductive Longevity and Equality (GCRLE), Buck Institute for Research on Aging (https://medicine.nus.edu.sg/cet/making-reproductive-longevity-a-reality/)
2021/03/31 Mapping Metabolic Programs in a Whole Animal at Single Cell Resolution 62nd Annual Drosophila Research Conference
Genetics Society of America (United States)
2020/12 How does cellular metabolic reprogramming control sugar appetite? Annual Portuguese Drosophila Meeting
(Portugal)
2020/10 How cellular metabolic reprogramming controls sugar appetite? World Obesity Day Virtual Workshop.
Champalimaud Centre for the Unknown (Lisboa, Portugal)
2020/01 The metabolic program of proliferating cells controls sugar cravings Post-Doc Exchange Programme
Instituto Gulbenkian de Ciência (Oeiras, Portugal)
2018/12/09 The metabolic program of proliferating cells controls sugar cravings Cell symposia - Metabolites as signaling molecules
(Seattle, United States)
2018/11/23 The gourmet fly: how nutrients and the microbiome shape nutritional decisions 22º Congresso Portugues de Obesidade
(Lisboa, Portugal)
2018/10 Metabolism in feeding behavior and disease Champalimaud student's Retreat
(Foz do Arelho, Portugal)
2017 Sugar appetite is controlled by the metabolic program of the germline European Drosophila Research Conference
(Londres, United Kingdom)
2017 Sugar appetite is controlled by the metabolic program of germline cells Drostuga - Portuguese Drosophila Meeting
(Tomar, Portugal)
2016 Commensal bacteria and essential amino acids control food choice behavior and reproduction Drostuga - Portuguese Drosophila Meeting
(Tomar, Portugal)
2009 Stepwise Evolution of Centriole Assembly Mechanisms FASEB Summer Research Conferences
(´Lucca, Italy)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/03/07 - 2023/05/23 How do ovarian tissues turn dietary sugars into eggs?
Supervisor
 Biologia Evolutiva e do Desenvolvimento (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade de Lisboa Instituto de Medicina Molecular, Portugal
2020/08/01 - 2023/03/14 The effects of tumorigenesis on nutrient cravings: dissecting the role of cellular metabolism in directing specific nutritional appetites to sustain high cell proliferation rates
Co-supervisor
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018 - 2019 Impact of the metabolic program of germline cells on feeding behaviour
Co-supervisor
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020 - Current Brain-Body Interactions Virtual Series (2020)
Other (Member of the Organising Committee)
2018/09 - 2019/09 Member of the organizing committee of the Annual Drosophila Portuguese Meeting (2019 - 2019)
Conference (Member of the Organising Committee)
2017 - 2019 Lisbon Area Post-Doc Symposium (2019 - 2019)
Symposium (Member of the Organising Committee)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/11 - 2018/11 Project Management Workshop, Prosciencia
Workshop
Programa Champalimaud de Neurociências, Portugal
2013/05 - 2013/05 Mechanisms of Nutritional Homeostasis in Insects
Workshop
LIMES-Institut, Germany
2012/06 - 2012/08 Exchange scientist visit
Marine Biological Laboratory Woods Hole Oceanographic Institution Library, United States
2011/06 - 2011/08 Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches
Workshop
Marine Biological Laboratory Woods Hole Oceanographic Institution Library, United States
2010/01 - 2010/01 Communicating Scientific Research 2010 Workshop
Instituto Gulbenkian de Ciência, Portugal
2008/05 - 2008/05 Workshop on Evolutionary Cell Biology
Workshop
Instituto Gulbenkian de Ciência, Portugal
2006/12 - 2006/12 Sequence Analysis using High Performance Computation
Workshop
Instituto Gulbenkian de Ciência, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/03/09 NUTRIENT POSTINGESTIVE SIGNALLING: THE ASYMMETRY OF THE RESPONSE OF DOPAMINERGIC NEURONAL CIRCUITS
(Thesis) Main arguer
 Carolina Quadrado (Master)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal

Fundação Champalimaud, Portugal
2023/02/23 Identification and characterisation of new players involved in the assembly of the meiotic spindle in Human oocytes
(Thesis) Main arguer
 Ana Maria Ferreira da Silva (Master)
Universidade de Lisboa Faculdade de Ciências, Portugal

Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2022/04/01 Neuronal control of suppression, initiation and completion of egg deposition in Drosophila melanogaster
(Thesis) Arguer
 Cristina Ferreira (PhD)
Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica, Portugal
2018/12/14 The role of succinate dehydrogenase in the Drosophila melanogaster intestinal stem cells and tissue homeostasis
(Thesis) Main arguer
 Ricardo André Baptista Pereira da Costa (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2023 - 2023 iScience
2021 - 2021 Nature Communications
2020 - 2020 Nature Communications
2018 - 2018 Nature Communications
2017 - 2017 Current Opinion in Insect Science
2016 - 2016 Current Biology
2015 - 2015 Elife
2013 - 2013 Development

Committee member

Activity description
Role 		Institution / Organization
2018 - 2019 Member of Champalimaud Post-Doctoral researchers committee
Member
 Programa Champalimaud de Neurociências, Portugal
2009 - 2010 Member of Instituto Gulbenkian de Ciência PhD students committee
Member
 Instituto Gulbenkian de Ciência, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/03/14 - 2024/03/14 Advanced Techniques in Biomedical Research II: Readouts of animal physiology Masters in Biomedical Research (Mestrado integrado) Universidade de Lisboa Instituto de Medicina Molecular, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2023/06 Interview for the Regional Newspaper Jornal de Leiria
2022/12/15 Interview for the Regional Newspaper Jornal de Leiria
2022/12/11 Interview for the National Newspaper Diário de Notícias Diário de Notícias
2022/03/03 Interview for Sábado Magazine in the context of the Fly Cell Atlas publication. Sábado Magazine
2021/02/11 Interview for the national newspaper Diário de Notícias - Da fertilidade à neurobiologia. As mulheres estão a mudar a ciência. Diario de Noticias
2020/09/09 Interview for the regional newspaper "O Portemosense" O Portemosense
2020/08/31 Há células sexuais que fazem com que as moscas-da-fruta anseiem por açucar Publico
2020/08 Interview for the regional newspaper "Jornal de Leiria" - Investigadora de Porto de Mós recebe prémio internacional Jornal de Leiria
2018/03/01 Interview for the regional newspaper "O Portemosense" - Dia da Mulher O Portemosense

Interview (tv / radio show)

Program Topic
2021/03 - 2021/03 Alô Portugal Dia da Mulher - Mulheres em Ciência
2012 - 2012 Jornal 10/12
2012 - 2012 Antena 1

Mentoring / Tutoring

Topic Student name
2023/05 - Current Diogo Louro
2021 - Current Member of PhD Thesis committee Catarina Costa
2023/05 - 2023/06 Raquel Nóbrega
2023/03 - 2023/06 Maria Inês Trindade Paulino Lorenzo Dominguez, Ana Rita Claro Correia
2019/11/01 - 2023/03/14 Research technician Inês Vicente
2018/07 - 2018/08 David Almeida, Faculdade de Ciencias e Tecnologia
2017 - 2018 Master students Rita Figueiredo, Faculdade de Ciencias e Tecnologia
2017/06 - 2017/08 Summer student Nick Archer, Princeton University
2015 - 2015 Rotational students Joana Saraiva, Universidade de Coimbra
Distinctions

Award

2022 Outstanding Poster Award in FASEB Reproductive Aging Conference
Federation of American Societies for Experimental Biology, United States
2020 Best Recorded Talk
Portuguese Drosophila Meeting, Portugal
2017 Second place for Best Oral Presentation
Portuguese Drosophila Meeting, Portugal
2016 Honourable mention for Best Oral Presentation
Portuguese Drosophila Meeting, Portugal
2012 Pfizer Award for Basic Investigation
2011 Marine Biological Laboratory Financial Aid Award
Marine Biological Laboratory, United States
2009 FASEB Young Scientist Travel Award
Federation of American Societies for Experimental Biology, United States
2008 American Society for Cell Biology Predoc Travel Award
American Society for Cell Biology, United States
2006 Menção Honrosa de Melhor Poster de Estagiário, Dia do Jovem Investigador
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2006 1º Prémio Concurso de Posters, Encontro Nacional de Estudanted de Biologia
Universidade do Porto Faculdade de Ciências, Portugal
2006 Menção Honrosa de Melhor Poster de Estagiário, Dia do Jovem Investigador
Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2006 1º Prémio Concurso de Posters Encontro Nacional de Estudanted de Biologia
Universidade do Porto Faculdade de Ciências, Portugal

Other distinction

2018 Best Poster award at Champalimaud Retreat 2018
Programa Champalimaud de Neurociências, Portugal
2017 As nossas apostas: 12 nomes que vão dar que falar em 2018
2011 European Association for Cancer Research travel Fellowship
European Association For Cancer Research, United Kingdom
2011 Boehringer Ingelheim Fonds travel Grant