Delfim Duarte is a physician-scientist interested in understanding ecological interactions between malignant and non-malignant cells and their surrounding microenvironments. He has a particular interest in bone marrow (BM) niches, normal and malignant hematopoiesis, vascular biology and intravital microscopy. Delfim obtained his MD at the Faculty of Medicine, University of Porto (FMUP). He has previously previously performed research in the fields of angiogenesis, inflammation and cell microparticles. In 2014, he moved to Cristina Lo Celso's lab (Imperial College London; GABBA program) where he studied the interaction between acute leukemic cells and BM niches. He reported that T-ALL is niche-agnostic and extremely motile and investigated the disruption of HSC-supporting niches in AML. In 2017, he was part of the European Hematology Association (EHA)-American Society Hematology (ASH) TRTH program. His research program is funded by several national and international projects. He was named Young Hematologist of the Year in 2019 and was awarded the National Hematology Prize in 2021, by the Portuguese Society of Hematology. He graduated from the residency/fellowship in Clinical Hematology in October 2023. He has published several papers, including first-author and senior publications in Nature, Cell Stem Cell, Blood, Blood Advances and Leukemia. Since 2024, he is a Hematologist specialist at the Department of Hematology and Bone Marrow Transplantation of IPO-Porto. Since 2021, he is a Group Leader (Hematopoiesis & Microenvironments Group) at i3s.
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Personal identification

Full name
Delfim Duarte

Citation names

  • Duarte, Delfim

Author identifiers

Ciência ID
DB1A-B4B5-B0D4
ORCID iD
0000-0003-3476-0211

Telephones

Mobile phone
  • 917351697 (Personal)

Addresses

  • Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Intermediate (B1) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2) Intermediate (B1)
French Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2) Elementary (A2)
Degree Classification
2018 - 2023
Concluded
 Hematologia Clínica (Especialidade) (Curso de Especialização Tecnológica)
Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
 19,77
2014 - 2018
Concluded
 Life Sciences (Doctor of Philosophy)
Imperial College London, United Kingdom
"In vivo imaging of the dynamic interactions of acute leukaemias with the bone marrow microenvironment" (THESIS/DISSERTATION)
 N/A
2006 - 2012
Concluded
 Medicina (Mestrado integrado)
Universidade do Porto Faculdade de Medicina, Portugal
"Endothelial microparticles (EMPs): implications in angiogenesis and angiogenesis-related diseases" (THESIS/DISSERTATION)
 16/20

Science

Category
Host institution 		Employer
2021/09/01 - Current Principal Investigator (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018 - 2021 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014 - 2017 Researcher (Research) Imperial College London Department of Life Sciences, United Kingdom
2011 - 2013 Research Trainee (Research) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2019 Invited Assistant (University Teacher) Universidade do Porto, Portugal
2013 - 2018 Invited Assistant (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2013 - 2016 Assistant (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2011 - 2012 Lecturer (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal

Other Careers

Category
Host institution 		Employer
2024 - Current Assistente (Médica) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2013 - 2023 Interno (Médica) Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal
2013 - 2013 Interno (Médica) Centro Hospitalar Universitário de São João, Portugal

Grant

Designation Funders
2021 - Current The role of iron-exporting monocytes in the remodeling of the vascular niche in AML
ASH
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 American Society of Hematology
Ongoing
2021 - Current Cell competition as a mechanism to eliminate minimal residual disease in acute myeloid leukemia
Pablove
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 The Pablove Foundation
Ongoing
2024 - 2027 Cell extrinsic regulation of acute myeloid leukemia progression and relapse
24-0425
Principal investigator
2022/01/01 - 2023/06/30 The role of endothelial Nrf2 in the vascular niche remodelling induced by acute myeloid leukemia
EXPL/MED-ONC/0522/2021
Principal investigator
Fundação para a Ciência e a Tecnologia
2018/07/01 - 2021/10/01 The role of CD18 in the AML-microenvironment interaction
Bolsa D. Manuel de Mello 2018
Bolsa SPH
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação Amélia de Mello

Sociedade Portuguesa de Hematologia
Ongoing
2019/08/01 - 2021/07/31 Targeting the bone marrow vascular microenvironment to improve hematopoietic stem cell therapies in acute myeloid leukemia
NBF Research Grant
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 AABB National Blood Foundation
Ongoing
2019/03/01 - 2021/02/28 The role of iron in the remodeling of the vascular niche in acute myeloid leukemia
EHA Physician-Scientist Research Grant
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 European Hematology Association
Ongoing
2014/01/01 - 2017/12/31 In vivo imaging of the dynamic interactions of acute leukaemias with the bone marrow microenvironment
FCT SFRH/BD/52195/2013
PhD Student Fellow
Imperial College London Department of Life Sciences, United Kingdom
 Fundação para a Ciência e a Tecnologia
Concluded
2014/01/01 - 2017/12/31 Changing lifestyle may prevent or revert pulmonary arterial hypertension
EA 14 23
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
Concluded
2012/10/01 - 2013/10/01 Microparticles as Biomarkers of Metabolic Syndrome in Asthma Patients
Prof. Ernesto Morais Foundation grant
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
Concluded
2011/07/15 - 2011/09/15 Dynamin in clathrin-dependent endocytosis
FCT / FLAD grant
Scientific Initiation Fellow
Harvard Medical School, United States

Contract

Designation Funders
2019/01/01 - 2019/12/31 Institute for Research and Innovation in Health Sciences
UID/BIM/04293/2019
LA/P/0070/2020
10.54499/LA/P/0070/2020
Instituto Nacional de Engenharia Biomédica, Portugal

Universidade do Porto, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2007/05/01 - 2012/10/01 Modulation of angiogenesis and inflammation by red wine and beer-derived polyphenols
University of Porto grant
Scientific Initiation Fellow
Universidade do Porto Faculdade de Medicina, Portugal

Publications

Conference abstract
  1. Ricardo Pires das Neves; Quartin, Emanuel; González Antón, Sara; Rosa, Susana; Francisco, Vitor; Mosteo, Laura; Duarte, Delfim; Lo Celso, Cristina; Ferreira, Lino. "Cells as therapeutical vehicles for the delivery of light sensitive retinoic acid nanoparticles for leukemic niche modulation". Paper presented in EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 2021.
    Published
Conference poster
  1. Lopes, Marta; Lemos, Filipa; Moreira-Barbosa, Catarina; Duarte, Tiago L; Teles, Maria Jose; Silva, AMN; Gonçalves, N; et al. "Apotransferrin in combination with induction chemotherapy has an antileukemic effect in an acute myeloid leukemia mouse mode". Paper presented in 1st Symposium on Iron Metabolism in Cancer, 2023.
  2. Lopes, Marta; Mosteo, Laura; Pereira, Carolina; Oliveira, Carla; Duarte, Delfim. "Cell competition as a mechanism to eliminate minimal residual disease in acute myeloid leukemia". Paper presented in 6th PhDay: Brilliant PhDs, brighter future: Shaping Science together!, 2023.
Journal article
  1. João L. Pereira; Liliana Arede; Francisca Ferreira; Andreia Matos; Dulcineia Pereira; Rita F. Santos; Alexandre M. Carmo; et al. "Antibody blockade of the PSGL-1 immune checkpoint enhances T-cell responses to B-cell lymphoma". Leukemia (2024): https://doi.org/10.1038/s41375-024-02446-w.
    10.1038/s41375-024-02446-w
  2. Manuel Mendes; Ana C. Monteiro; Estrela Neto; Cristina C. Barrias; Manuel A. Sobrinho-Simões; Delfim Duarte; Hugo R. Caires. "Transforming the Niche: The Emerging Role of Extracellular Vesicles in Acute Myeloid Leukaemia Progression". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25084430.
    10.3390/ijms25084430
  3. Emanuel Quartin; Susana Rosa; Sara Gonzalez-Anton; Laura Mosteo Lopez; Vitor Francisco; Delfim Duarte; Cristina Lo Celso; Ricardo Pires das Neves; Lino Ferreira. "Nanoparticle-encapsulated retinoic acid for the modulation of bone marrow hematopoietic stem cell niche". Bioactive Materials (2024): https://doi.org/10.1016/j.bioactmat.2023.12.017.
    10.1016/j.bioactmat.2023.12.017
  4. Pinheiro FO; Duarte D; Rodrigues P; Nogueira-Silva L; Martins JC; Almeida J. "Subacute Neurotoxicity as an Adverse Reaction to Ceftazidime: A Case Report.". The Kurume medical journal (2024): https://doi.org/10.2739/kurumemedj.MS6934009.
    10.2739/kurumemedj.ms6934009
  5. Tiago Duarte; Marta Lopes; Oliveira M; Santos AG; Catarina Vasco; Reis JP; Antunes AR; et al. "Iron overload induces dysplastic erythropoiesis and features of myelodysplasia in Nrf2-deficient mice.". Leukemia (2023): https://doi.org/10.1038/s41375-023-02067-9.
    10.1038/s41375-023-02067-9
  6. Delfim Duarte; José Mário Mariz. "Erythema nodosum as a manifestation of cytokine release syndrome after CAR T-cell therapy". Annals of Hematology (2023): https://doi.org/10.1007/s00277-023-05338-8.
    10.1007/s00277-023-05338-8
  7. Delfim Duarte; Sérgio Chacim. "The details are in the nails—A case of salient chemotherapy-induced changes of the fingernails". British Journal of Haematology (2023): https://doi.org/10.1111/bjh.18673.
    10.1111/bjh.18673
  8. Delfim Duarte; Laura Mosteo; Joana Reis; Lídia Rocha; Marta Lopes. "Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells". Journal of Visualized Experiments 187 (2022): http://dx.doi.org/10.3791/64248.
    10.3791/64248
  9. Delfim Duarte; Maria P. Coutinho; Maria José Teles; Graça Melo; Marta Lopes; Tiago L. Duarte; Júlia Reis; et al. "Ferritin Increase in Hemochromatosis Subjects After Discontinuing Their Regular Maintenance Treatment: A Longitudinal Analysis Performed During the COVID-19 Imposed Hospital Lockdown". HemaSphere 6 9 (2022): e770-e770. http://dx.doi.org/10.1097/hs9.0000000000000770.
    10.1097/hs9.0000000000000770
  10. "Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness.". Blood advances (2022): https://doi.org/10.1182/bloodadvances.2021004321.
    10.1182/bloodadvances.2021004321
  11. Coelho, S.; Ribeiro, T.; Pereira, I.; Duarte, D.; Afonso, A.; Meneses, I.; Pinelas, S.; et al. "Acute organ failure and risk of admission to intensive medical care in cancer patients: a single center prospective cohort study,Falência aguda de órgão e risco de admissão em unidade de terapia intensiva nos pacientes oncológicos: estudo de coorte prospectivo unicêntrico". Revista Brasileira de terapia intensiva 33 4 (2022): 583-591. http://www.scopus.com/inward/record.url?eid=2-s2.0-85123816599&partnerID=MN8TOARS.
    10.5935/0103-507X.20210085
  12. Lopes, Marta; Duarte, Tiago L.; Teles, Maria J.; Mosteo, Laura; Chacim, Sérgio; Aguiar, Eliana; Pereira-Reis, Joana; et al. "Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications". Blood Advances 5 16 (2021): 3102-3112. http://dx.doi.org/10.1182/bloodadvances.2021004373.
    10.1182/bloodadvances.2021004373
  13. Delfim Duarte; Cátia Iracema Morais; Rosa Azevedo; Fernando Coelho; Anabela Martins; Brigitte Pereira; Sara Coelho; et al. "Disseminated Saprochaete capitata fungal infection in a patient with acute myeloid leukemia". Clinical Case Reports 9 4 (2021): 2489-2491. https://doi.org/10.1002/ccr3.3993.
    10.1002/ccr3.3993
  14. Luigi Ombrato; Emma Nolan; Diana Passaro; Ivana Kurelac; Victoria L. Bridgeman; Alexander Waclawiczek; Delfim Duarte; et al. "Generation of neighbor-labeling cells to study intercellular interactions in vivo". Nature Protocols (2021): https://doi.org/10.1038/s41596-020-00438-5.
    10.1038/s41596-020-00438-5
  15. Sinha, S.; Pereira-Reis, J.; Guerra, A.; Rivella, S.; Duarte, D.. "The Role of Iron in Benign and Malignant Hematopoiesis". Antioxidants and Redox Signaling 35 6 (2021): 415-432. http://www.scopus.com/inward/record.url?eid=2-s2.0-85105672354&partnerID=MN8TOARS.
    10.1089/ars.2020.8155
  16. Mosteo, L.; Storer, J.; Batta, K.; Searle, E.J.; Duarte, D.; Wiseman, D.H.. "The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy". Frontiers in Cell and Developmental Biology 9 (2021): http://www.scopus.com/inward/record.url?eid=2-s2.0-85103027137&partnerID=MN8TOARS.
    10.3389/fcell.2021.635189
  17. Nora, E.; Naik, S.; Giustacchini, A.; Rodriguez Colman, M.J.; Aragona, M.; Duarte, D.. "Introductions to the Community: Early-Career Researchers in the Time of COVID-19". Cell Stem Cell 27 3 (2020): 359-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-85089949430&partnerID=MN8TOARS.
    10.1016/j.stem.2020.08.009
  18. Pirillo, Chiara; Haltalli, Myriam; Gonzalez-anton, Sara; Adams, George; Duarte, Delfim; Lo Celso, Cristina. "Inhibiting Matrix Metalloproteinases Hinders Acute Myeloid Leukaemia and Prevents Healthy Stem Cell Loss". Blood 134 Supplement (2019): 2487-2487. http://dx.doi.org/10.1182/blood-2019-129847.
    10.1182/blood-2019-129847
  19. Duarte, Delfim. "Ever-changing homes". Porto Biomedical Journal 4 2 (2019): e33. http://dx.doi.org/10.1016/j.pbj.0000000000000033.
    10.1016/j.pbj.0000000000000033
  20. Jafarnejad, M.; Ismail, A.Z.; Duarte, D.; Vyas, C.; Ghahramani, A.; Zawieja, D.C.; Lo Celso, C.; Poologasundarampillai, G.; Moore, J.E.. "Quantification of the Whole Lymph Node Vasculature Based on Tomography of the Vessel Corrosion Casts". Scientific Reports 9 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072275567&partnerID=MN8TOARS.
    10.1038/s41598-019-49055-7
  21. Silva, A.F.; Faria-Costa, G.; Sousa-Nunes, F.; Santos, M.F.; Ferreira-Pinto, M.J.; Duarte, D.; Rodrigues, I.; et al. "Anti-remodeling effects of xanthohumol-fortified beer in pulmonary arterial hypertension mediated by ERK and AKT inhibition". Nutrients 11 3 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85062834189&partnerID=MN8TOARS.
    10.3390/nu11030583
  22. Duarte, D.; Amarteifio, S.; Ang, H.; Kong, I.Y.; Ruivo, N.; Pruessner, G.; Hawkins, E.D.; Lo Celso, C.. "Defining the in vivo characteristics of acute myeloid leukemia cells behavior by intravital imaging". Immunology and Cell Biology 97 2 (2019): 229-235. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058390194&partnerID=MN8TOARS.
    10.1111/imcb.12216
  23. Bianchi, Giada; Duarte, Delfim; Neuberg, Donna S.. "The Benefits of TRTHing along". HemaSphere (2018): 1. http://dx.doi.org/10.1097/hs9.0000000000000138.
    10.1097/hs9.0000000000000138
  24. Gavin Tjin; Eugenia Flores-Figueroa; Delfim Duarte; Lenny Straszkowski; Mark Scott; Reema A. Khorshed; Louise E. Purton; Cristina Lo Celso. "Imaging methods used to study mouse and human HSC niches: Current and emerging technologies". Bone (2018): https://doi.org/10.1016%2Fj.bone.2018.04.022.
    10.1016/j.bone.2018.04.022
  25. Delfim Duarte; Edwin D. Hawkins; Cristina Lo Celso. "The interplay of leukemia cells and the bone marrow microenvironment". Blood 131 14 (2018): 1507-1511. https://doi.org/10.1182%2Fblood-2017-12-784132.
    10.1182/blood-2017-12-784132
  26. Akinduro, O.; Weber, T.S.; Ang, H.; Haltalli, M.L.R.; Ruivo, N.; Duarte, D.; Rashidi, N.M.; et al. "Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space". Nature Communications 9 1 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85041639415&partnerID=MN8TOARS.
    10.1038/s41467-017-02376-5
  27. Bianchi, G.; Duarte, D.; Neuberg, D.S.. "The benefits of TRTHing along". HemaSphere 2 4 (2018): http://www.scopus.com/inward/record.url?eid=2-s2.0-85088222175&partnerID=MN8TOARS.
    10.1097/HS9.0000000000000138
  28. Athanasiou, D.; Edgar, L.T.; Jafarnejad, M.; Nixon, K.; Duarte, D.; Hawkins, E.D.; Jamalian, S.; et al. "The passive biomechanics of human pelvic collecting lymphatic vessels". PLoS ONE 12 8 (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85027868260&partnerID=MN8TOARS.
    10.1371/journal.pone.0183222
  29. Delfim Duarte; Edwin D. Hawkins; Olufolake Akinduro; Heather Ang; Katia De Filippo; Isabella Y. Kong; Myriam Haltalli; et al. "Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML". Cell Stem Cell (2017): https://doi.org/10.1016%2Fj.stem.2017.11.006.
    10.1016/j.stem.2017.11.006
  30. Edwin D. Hawkins; Delfim Duarte; Olufolake Akinduro; Reema A. Khorshed; Diana Passaro; Malgorzata Nowicka; Lenny Straszkowski; et al. "T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments". Nature (2016): http://dx.doi.org/10.1038/nature19801.
    10.1038/nature19801
  31. Khorshed, R.A.; Hawkins, E.D.; Duarte, D.; Scott, M.K.; Akinduro, O.A.; Rashidi, N.M.; Spitaler, M.; Lo Celso, C.. "Automated Identification and Localization of Hematopoietic Stem Cells in 3D Intravital Microscopy Data". Stem Cell Reports 5 1 (2015): 139-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937523490&partnerID=MN8TOARS.
    10.1016/j.stemcr.2015.05.017
  32. Costa, R.; Negrão, R.; Valente, I.; Castela, A.; Duarte, D.; Guardão, L.; Magalhães, P.J.; et al. "Xanthohumol modulates inflammation, oxidative stress, and angiogenesis in type 1 diabetic rat skin wound healing". Journal of Natural Products 76 11 (2013): 2047-2053. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888385770&partnerID=MN8TOARS.
    10.1021/np4002898
  33. Negrão, R.; Costa, R.; Duarte, D.; Gomes, T.T.; Azevedo, I.; Soares, R.. "Different effects of catechin on angiogenesis and inflammation depending on VEGF levels". Journal of Nutritional Biochemistry 24 2 (2013): 435-444. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872779241&partnerID=MN8TOARS.
    10.1016/j.jnutbio.2011.12.011
  34. Duarte, D.; Taveira-Gomes, T.; Sokhatska, O.; Palmares, C.; Costa, R.; Negrão, R.; Guimarães, J.T.; et al. "Increased circulating platelet microparticles as a potential biomarker in asthma". Allergy: European Journal of Allergy and Clinical Immunology 68 8 (2013): 1073-1075. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883181922&partnerID=MN8TOARS.
    10.1111/all.12190
  35. Negrão, R.; Duarte, D.; Costa, R.; Soares, R.. "Isoxanthohumol modulates angiogenesis and inflammation via vascular endothelial growth factor receptor, tumor necrosis factor alpha and nuclear factor kappa B pathways". BioFactors 39 6 (2013): 608-622. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888135448&partnerID=MN8TOARS.
    10.1002/biof.1122
  36. Negrão, R.; Costa, R.; Duarte, D.; Gomes, T.T.; Coelho, P.; Guimarães, J.T.; Guardão, L.; Azevedo, I.; Soares, R.. "Xanthohumol-supplemented beer modulates angiogenesis and inflammation in a skin wound healing model. Involvement of local adipocytes". Journal of Cellular Biochemistry 113 1 (2012): 100-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-84055177148&partnerID=MN8TOARS.
    10.1002/jcb.23332
  37. Kural, C.; Tacheva-Grigorova, S.K.; Boulant, S.; Cocucci, E.; Baust, T.; Duarte, D.; Kirchhausen, T.. "Dynamics of Intracellular Clathrin/AP1- and Clathrin/AP3-Containing Carriers". Cell Reports 2 5 (2012): 1111-1119. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870401535&partnerID=MN8TOARS.
    10.1016/j.celrep.2012.09.025
  38. Duarte, D.; Santos-Araújo, C.; Leite-Moreira, A.F.. "Hypertension and angiogenesis in the aging kidney: A review". Archives of Gerontology and Geriatrics 52 3 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953068970&partnerID=MN8TOARS.
    10.1016/j.archger.2010.11.032
  39. Negrão, R.; Duarte, D.; Costa, R.; Soares, R.. "Could platelet-accumulating polyphenols prevent tumour metastasis?". Nature Reviews Cancer 11 9 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-80052045759&partnerID=MN8TOARS.
    10.1038/nrc3004-c1
  40. Negrão, R.; Costa, R.; Duarte, D.; Taveira Gomes, T.; Mendanha, M.; Moura, L.; Vasques, L.; Azevedo, I.; Soares, R.. "Angiogenesis and inflammation signaling are targets of beer polyphenols on vascular cells". Journal of Cellular Biochemistry 111 5 (2010): 1270-1279. http://www.scopus.com/inward/record.url?eid=2-s2.0-78649890064&partnerID=MN8TOARS.
    10.1002/jcb.22850

Other

Other output
  1. Loss of erythroblasts in acute myeloid leukemia causes iron redistribution with clinical implications. 2020. Lopes M; Duarte TL; Teles MJ; Mosteo L; Chacim S; Aguiar E; Pereira-Reis J; et al. http://europepmc.org/abstract/PPR/PPR230767.
    10.1101/2020.10.26.350116
  2. The metalloproteinase inhibitor prinomastat reduces AML growth, prevents stem cell loss and improves chemotherapy effectiveness. 2020. Pirillo, C.; Haltalli, M.; Anton, S.G.; Tini, V.; Kong, I.; Hawkins, E.; Falini, B.; et al. http://www.scopus.com/inward/record.url?eid=2-s2.0-85099900866&partnerID=MN8TOARS.
    10.1101/2020.12.01.393157
  3. Imaging the Hematopoietic Stem Cell Niche. Advances in Stem Cells and their Niches. 2017. D. Duarte; C. Lo Celso; Duarte, D.; Lo Celso, C.. https://doi.org/10.1016%2Fbs.asn.2017.01.002.
    10.1016/bs.asn.2017.01.002

Oral presentation

Presentation title Event name
Host (Event location)
2017 Invited to present his research work in several international meetings including the 45th European Calcified Tissue Society (ECTS) Congress. Valencia, Spain (May 2018), the Institut Cochin-JC Dreyfus Symposium “Hematologic and Solid Tumor Oncology”, Paris, France (September 2017), the Stem Cell Forum, The Francis Crick Institute. London, UK. 24 July 2017 and the Annual Meeting of the Portuguese Society of Hematology 2019.

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021/11/01 - 2025/10/30 Cell competition as a mechanism to eliminate minimal residual disease in acute myeloid leukemia
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/12/01 - 2024/11/30 The role of iron in the remodeling of the vascular niche in acute myeloid leukemia
Supervisor
 Molecular and Cellular Biology (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023 - 2023 Eritropoiese em doentes com hemocromatose e dadores de sangue
Co-supervisor
 Análises Clínicas e Saúde Pública (Master)
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2023 - 2023 The impact of acute myeloid leukemia-induced niche remodeliling in disease progression, chemoresistance and relapse
Supervisor
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022 - 2022 Cell competition as a mechanism to eliminate minimal residual disease in acute myeloid leukemia
Supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/01 - 2021/03/31 The Nrf2-/-/Hamp1 -/- mouse as a model of myelodysplasia
Supervisor
 Mestrado Integrado em Medicina (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/01/01 - 2021/01/31 In vivo study of acute myeloid leukemia-induced heme toxicity on endothelial cells - retinal angiogenesis as a model
Supervisor
 Mestrado de Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - 2021 The Nrf2/Hamp1-/- mouse as a model of Myelodysplasia
Supervisor
 Medicina (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - 2021 The effect of iron and Nrf2 on endothelial cells - the retinal angiogenesis as a model
Supervisor
 Oncologia (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021 - 2021 The role of iron in the remodeling of the vascular niche in acute myeloid leukemia
Supervisor
 Biologia Molecular e Celular (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014 - 2014 Organizing Committee, GABBA Annual Symposium 2014 – “Communicating Life” (2014 - 2014)
2008 - 2011 Scientific Program, Vice-President and President, Young European Scientist (YES) Meeting, Porto, PT (2008 - 2011)
Meeting (Member of the Organising Committee)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021 Environmental Signals Driving the Onset of Hematopoiesis in the Fetal Liver
Thesis Member
 Francisca Castro Gomes Soares da Silva (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Association member

Society Organization name Role
2020 - Current Member, BioIron: the International Society for the Study of Iron in Biology and Medicine
2018 - Current International Associate, American Society of Hematology (ASH)
2015 - Current Member, European Hematology Association (EHA)
2015 - Current Member, European Association for Cancer Research (EACR) and Portuguese Association for Cancer Research (ASPIC)
2012 - Current Member, Portuguese Medical Association / Ordem dos Médicos
2015 - 2017 Member, British Society of Cell Biology (BSCB)

Committee member

Activity description
Role 		Institution / Organization
2016 - 2017 Member, Imperial College’s Animal Welfare and Ethical Review Body (AWERB)
2010 - 2012 Student Representative, Pedagogic Council, Faculty of Medicine, University of Porto
Member

Journal scientific committee

Journal title (ISSN) Publisher
2020/02/01 - Current Frontiers in Cell and Developmental Biology (2296-634X) Frontiers

Other jury / evaluation

Activity description Institution / Organization
2014 - Current Acted as grant reviewer for the European Hematology Association, Medical Research Council (MRC) UK and Leukaemia UK. Acted as manuscript reviewer for Blood, Oncogene, Scientific Reports, Cells, Antioxidants, Journal of Cellular and Molecular Medicine, PLoS One and Porto Biomedical Journal (PBJ). Assisted his supervisor reviewing for Nature Methods, Science Translational Medicine, eLife, Journal of Visualized Experiments (JoVE) and IntraVital.

Award

2021 National Hematology Prize
Sociedade Portuguesa de Hematologia, Portugal
2019 Young Hematologist of the Year Award
Sociedade Portuguesa de Hematologia, Portugal

Other distinction

2019 One of the top papers of 2019 (Duarte D et al. Defining the in vivo characteristics of acute myeloid leukemia cells behavior by intravital imaging. Immunol Cell Biol 97: 229-35)
2018 Best Speed Talk at the 25th Porto Cancer Meeting - Cancer Wars: The Immune Force Awakens. I3S, Porto, Portugal
2017 Selected Researcher, EHA-ASH Translational Research Training in Hematology
European Hematology Association, Netherlands

American Society of Hematology, United States
2016 Selected Junior Researcher, Workshop “Rethinking cancer”, The Company of Biologists
The Company of Biologists, United Kingdom
2010 Portuguese Representative, World Health Organization (WHO) Youth Network, 5th Ministerial Conference on Environment and Health, Parma, Italy