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Graduation in Physics Engineering by the University of Coimbra, Portugal. PhD in Physics by the Darmstadt University of Technology, Germany. Worked at the German heavy ion tumor therapy project for 7.5 years as PhD candidate and as postdoc researcher. Work involved physical and technological developments, and participation in the treatment of more than 200 cancer patients with carbon ion radiotherapy at GSI in Darmstadt. Co-invented 2 patents granted to his former laboratory HZDR in Dresden, Germany. Works since 2007 in Portugal at LIP Coimbra, as principal investigator since 2009. Lectured for 3 years at the Polytechnic Institute of Coimbra and is assistant professor at the Physics Department of the University of Coimbra since 2013. Co-authored 48 publications in peer-reviewed journals, and 42 publications in international conference records. IoP (Institute of Physics) awarded to one of his first-author publication in Phys. Med. Biol. the highlight of 2006, an yearly distinction to the top 10 scientific articles of largest impact within the journal. Co-authored 4 chapters in 2 books in nuclear medicine, is a reviewer of 10 different journals and has refereed, by invitation, international funding projects amounting to above 1 million EUR. Co-author of the proposal of the project Rad4Life, which was financed with 1.2 million EUR between July 2013 and September 2015. Has supervised 14 master theses and 4 doctoral works at the University of Coimbra. Presently working on (1) R&D of imaging devices for assisting and potentially improving the effectiveness of external X- ray and proton beam radiotherapy (orthogonal X-rays, prompt gamma imaging, and in-beam time-of-flight positron emission tomography–PET), (2) PET with resistive plate chambers, and (3) new device for deep- and whole-brain transcranial magnetic stimulation. Attracted more than 400 thousand EUR to be managed by LIP Coimbra in the last 4 years, distributed over several of the aforementioned lines of research.
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Identification

Personal identification

Full name
Paulo Alexandre Vieira Crespo

Citation names

  • Crespo, Paulo
  • Crespo, P

Author identifiers

Ciência ID
DE18-4FCE-42DB
ORCID iD
0000-0002-0891-032X

Email addresses

  • crespo@lip.pt (Professional)

Telephones

Mobile phone
  • 926131578 (Personal)
Telephone
  • 239410662 (Professional)

Addresses

  • LIP - Laboratório de Instrumentação e Física Experimenal de Partículas. Departamento de Física da Universidade de Coimbra, 3004-516, Coimbra, Coimbra, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Radiology, Nuclear Medicine and Medical Imaging
  • Exact Sciences - Physical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Spanish; Castilian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Italian Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
German Upper intermediate (B2) Upper intermediate (B2) Elementary (A2) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2005/12/21
Concluded
 Physik (Doutoramento)
Technische Universität Darmstadt Fachbereich Physik, Germany
"Optimization of In- Beam Positron Emission Tomography for Monitoring Heavy Ion Tumor Therapy" (THESIS/DISSERTATION)
 Very Good
1991/09/01 - 1997/07/30
Concluded
 Engenharia Física (Licenciatura)
Major in Instrumentation
Universidade de Coimbra Departamento de Física, Portugal
 16
Affiliation

Science

Category
Host institution 		Employer
2007/06/01 - Current Principal Investigator (Research) Laboratório de Instrumentação e Física Experimental de Partículas Coimbra, Portugal
2006/01/01 - 2007/04/30 Auxiliary Researcher (Research) Helmholz-Zentrum Dresden-Rossendorf, Germany

Teaching in Higher Education

Category
Host institution 		Employer
2013/11/15 - Current Assistant Professor (University Teacher) Universidade de Coimbra, Portugal
2008/09/01 - 2011/07/31 Invited Assistant (Polytechnic Teacher) Instituto Politécnico de Coimbra, Portugal
Instituto Politécnico de Coimbra Instituto Superior de Engenharia de Coimbra, Portugal
Projects

Contract

Designation Funders
2022/01/01 - 2024/08/31 Optimization, construction and first in-beam tests of range monitoring and quality assurance systems for the improvement of proton therapy
CERN/FIS-TEC/0017/2021
Other
Laboratório de Instrumentação e Física Experimental de Partículas Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/06/30 TPPT - In-beam time-of-flight positron emission tomography for proton radiation therapy
CENTRO-01-0247-FEDER-045904
Principal investigator
Laboratório de Instrumentação e Física Experimental de Partículas Coimbra, Portugal
 Agência Nacional de Inovação SA
Concluded
2020/01/01 - 2021/12/31 Proton therapy: real-time prompt gamma imaging and microdosimetry
CERN/FIS-TEC/0019/2019
Principal investigator
Laboratório de Instrumentação e Física Experimental de Partículas Coimbra, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Crespo, Paulo; Caramelo, F.; Guerreiro, C.; Ferreira, N.. "Chapter 5: Radiation detectors and image formation". In Nuclear Medicine Physics, edited by Pedroso de Lima, J. J.. CRC Press - Taylor & Francis Group, 2010.
    Published
  2. Crespo, Paulo; Ferreira, N.; Guerreiro, C.; Botelho, M. F.; Costa, D. C.; Araújo, H.. "Chapter 6: Imaging methodologies". In Nuclear Medicince Physics, edited by Pedroso de Lima, J. J.. CRC Press - Taylor & Francis Group, 2010.
    Published
  3. Crespo, Paulo; Caramelo, F.; Guerreiro, C.; Ferreira, N.. "Capítulo 5: Detectores de radiação e produção de imagem". In Física em Medicina Nuclear, edited by Pedroso de Lima, J. J.. Imprensa da Universidade de Coimbra, 2008.
    Published
  4. Crespo, Paulo; Ferreira, N.; Guerreiro, C.; Botelho, M. F.; Costa, D. C.; Araújo, H.. "Capítulo 6: Métodos de imagem". In Física em Medicina Nuclear, edited by Pedroso de Lima, J. J.. Imprensa da Universidade de Coimbra, 2008.
    Published
Conference paper
  1. Simões, H.; Marques, R.F.; Rachinhas, P.J.B.M.; Wagner, A.; Crespo, P.. "Rotation-Free Scattered-Radiation Imaging with a Radiotherapy X-Ray Linac". 2018.
    10.1109/NSSMIC.2018.8824227
  2. Simoes, H.; Lopes, A.L.; Crespo, P.. "Ortho CT for tumor head irradiation: A simulation study". 2017.
    10.1109/NSSMIC.2016.8069473
  3. Travassos, C.; Simoes, H.; Crespo, P.; Barros, M.A.; Lencart, J.; Rachinhas, P.J.B.M.; Santos, J.A.M.. "Experimental characterization of megavoltage beams for orthogonal ray imaging". 2017.
    10.1109/NSSMIC.2016.8069472
  4. Lopes, A.L.; Simões, H.; Crespo, P.; Barata, J.A.S.; Lencart, J.; Santos, J.A.M.. "Impact of tumor contrast in orthogonal ray imaging: A prostate irradiation study". 2017.
    10.1109/NSSMIC.2016.8069392
  5. Simoes, H.; Barros, M.A.; Crespo, P.. "Orthoct for tumor lung irradiation: A simulation study". 2017.
    10.1109/NSSMIC.2016.8069391
  6. Sousa, S.C.P.; Almeida, J.; Miranda, P.C.; Salvador, R.; Silvestre, J.; Simoes, H.; Crespo, P.. "Optimization of multiple coils immersed in a conducting liquid for half-hemisphere or whole-brain deep transcranial magnetic stimulation: A simulation study". 2014.
    10.1109/EMBC.2014.6943647
  7. Simoes, H.; Dias Silva, M.; Vieira Ferreira, C.; Jesus, L.; Oliveira, H.; Miranda, P.C.; Salvador, R.; Crespo, P.; Silvestre, J.. "Experimental demonstration of induction by means of a transcranial magnetic stimulator coil immersed in a conducting liquid". Paper presented in ENBENG 2013, 2013.
    10.1109/ENBENG.2013.6518402
  8. Martins, P.; Blanco, A.; Crespo, P.; Ferreira Marques, M.F.; Marques, R.F.; Gordo, P.M.; Kajetanowicz, M.; et al. "Achieving 0.4-mm FWHM spatial resolution with an RPC-based small-animal PET prototype". 2013.
    10.1109/NSSMIC.2013.6829105
  9. Simões, H.; Bravo, I.; Capela, M.; Cavaco, A.; Ferreira Marques, R.; Fonte, P.; Lencart, J.; et al. "Observation of tumor morphological changes in lung irradiation with orthogonal ray imaging: RTmonitoring - A simulation study". 2013.
    10.1109/NSSMIC.2013.6829313
  10. Simoes, H.; Ghithan, S.; Loureiro, M.; Crespo, P.. "Characterization of GSO:Ce phosphorescence after low-dose-rate gamma-ray irradiation". 2013.
    10.1109/NSSMIC.2013.6829626
  11. Ghithan, S.; Do Carmo, S.J.C.; Marques, R.F.; Fraga, F.A.F.; Simoes, H.; Alves, F.; Crespo, P.. "Fast and precise verification of proton beam position, range, and dose using a plastic scintillator at PET-dedicated cyclotrons". 2013.
    10.1109/NSSMIC.2013.6829604
  12. Simoes, Hugo; Battaglia, Maria Cristina; Capela, Miguel; Lopes, Maria do Carmo; Crespo, Paulo. "Rotation-free computed tomography with orthogonal ray imaging: First millimetric experimental results". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551828
  13. Ghithan, Sharif; Alves, Francisco; Carmo, Sergio; Marques, Rui Ferreira; Fraga, Francisco; Simoes, Hugo; Crespo, Paulo. "Towards a high-dynamic dose-range irradiation setup for radiobioloy and radiophysiology". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551307
  14. Martins, Paulo; Crespo, Paulo; Ferreira Marques, Rui; Kajetanowicz, Marcin; Korcyl, Grzegorz; Lopes, Luis; Michel, Jan; et al. "Experimental sub-millimeter resolution with a small-animal RPC-PET prototype". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551863
  15. Cambraia Lopes, P.; Pinto, M.; Simoes, H.; Biegun, A. K.; Dendooven, P.; Oxley, D. C.; Parodi, K.; Schaart, D. R.; Crespo, P.. "Optimization of collimator designs for real-time proton range verification by measuring prompt gamma rays". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551886
  16. Battaglia, Maria Cristina; Simoes, Hugo; Bellini, Vincenzo; Cisbani, Evaristo; Lopes, Maria do Carmo; Crespo, Paulo. "Orthogonal ray imaging with megavoltage beams: Simulated results with an anthropomorphic phantom". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551884
  17. Martins, Paulo; Couceiro, Miguel; Ferreira, Nuno C.; Ferreira Marques, Rui; Fonte, Paulo; Mendes, Luis; Crespo, Paulo. "On lesion detectability by means of 300ps-FWHM TOF whole-body RPC-PET: An experiment-based simulation study". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551555
  18. Simoes, Hugo; Battaglia, Maria Cristina; Capela, Miguel; Cavaco, Ana; Lopes, Maria do Carmo; Rachinhas, Paulo J.B.M.; Soares, Paula; Simoes, PauloC.P.S.; Crespo, Paulo. "LYSO scintillators coupled to phototransistors for orthogonal ray imaging: Experimental results at 4 and 6-MV linacs". Paper presented in 2012 IEEE NSS/MIC, 2012.
    10.1109/nssmic.2012.6551885
  19. Ghithan, Sharif; Simoes, Hugo; Alves, Francisco; Carmo, Sergio; Cunha, Micaela; Marques, Rui Ferreira; Fraga, Francisco; Pinto, Marco; Crespo, Paulo. "Preliminary characterization of the external proton beam from a PET cyclotron for use in neutron and proton radiobiology and other dosimetric studies". Paper presented in ENBENG 2012, 2012.
    10.1109/enbeng.2012.6331362
  20. Dias Silva, Marilia; Ferreria, Carina Vieira; Oliveira, Holder; Fonte, Paulo; Jesus, Luis; Salvador, Ricardo; Silvestre, Joao; Crespo, Paulo. "Multiple coils in a conducting liquid for deep and whole-brain transcranial magnetic stimulation. II. Multiple-frequency excitation". Paper presented in ENBENG 2012, 2012.
    10.1109/enbeng.2012.6331375
  21. Oliveira, Helder; Dias Silva, Marilia; Ferreira, Carina Vieira; Fonte, Paulo; Jesus, Luis; Salvador, Ricardo; Silvestre, Joao; Crespo, Paulo. "Multiple coils in a conducting liquid for deep and whole-brain transcranial magnetic stimulation. I. Single-frequency excitation". Paper presented in ENBENG 2012, 2012.
    10.1109/enbeng.2012.6331374
  22. Martins, P.; Blanco, A.; Caramelo, F.; Couceiro, M.; Ferreira, N.C.; Ferreira Marques, R.; Fonte, P.; Mendes, L.; Crespo, P.. "A direct time-of-flight reconstruction for whole-body single-bed RPC-PET: Results from lesion and anthropomorphic simulated data". Paper presented in 2011 IEEE NSS/MIC, 2011.
    10.1109/NSSMIC.2011.6152701
  23. Simões, H.; Pinto, M.; Cunha, M.; Gonçalves, J.; Sampaio, L.; Ferreira, R.J.; Saraiva, H.M.; et al. "Dose-free monitoring of radiotherapy treatments with scattered photons: First experimental results at a 6-MV Linac". Paper presented in 2011 IEEE NSS/MIC, 2011.
    10.1109/NSSMIC.2011.6153827
  24. Biegun, A.K.; Seravalli, E.; Cambraia Lopes, P.; Rinaldi, I.; Pinto, M.; Oxley, D.C.; Dendooven, P.; et al. "Range and density variations monitoring during proton therapy based on time-of-flight detection of prompt gamma radiation". Paper presented in 2011 IEEE NSS/MIC, 2011.
    10.1109/NSSMIC.2011.6152641
  25. Cunha, M.; Pinto, M.; Ferreira, B.; Lopes, M.D.C.; Fonte, P.; Crespo, P.. "Dose-free monitoring of radiotherapy treatments with scattered photons: Concept and simulation study". Paper presented in 2011 IEEE NSS/MIC, 2011.
    10.1109/NSSMIC.2011.6153645
  26. Cunha, M.; Pinto, M.; Alves, F.; Crespo, P.; Marques, R.F.. "Radiobiology with cyclotron proton beams: A viability study". Paper presented in 2010 IEEE NSS/MIC, 2010.
    10.1109/NSSMIC.2010.5874028
  27. Makinaga, A.; Rusev, G.; Schwengner, R.; Do¨nau, F.; Beyer, R.; Bemmerer, D.; Crespo, P.; et al. "Cross section measurement on [sup 139]La¿(¿,¿’) below neutron separation energy". Paper presented in AIP, 2010.
    10.1063/1.3455936
  28. Crespo, P.; Reis, J.; Couceiro, M.; Blanco, A.; Ferreira, N.C.; Marques, R.F.; Fonte, P.. "Whole-body single-bed time-of-flight RPC-PET: Simulation of axial and planar sensitivities with NEMA and anthropomorphic phantoms". Paper presented in 2009 IEEE NSS/MIC, 2009.
    10.1109/NSSMIC.2009.5401775
  29. Shakirin, G.; Crespo, P.; Enghardt, W.. "On the optimum strategy for subsets based reconstruction of in-beam PET data". Paper presented in 2008 IEEE NSS/MIC, 2008.
    10.1109/NSSMIC.2008.4774101
  30. Shakirin, G.; Crespo, P.; Fiedler, F.; Wagner, A.; Enghardt, W.. "Optimum voxel size for reconstruction of In-Beam Pet data". Paper presented in 2008 IEEE NSS/MIC, 2008.
    10.1109/NSSMIC.2008.4774377
  31. Shakirin, G.; Crespo, P.; Braess, H.; Enghardt, W.. "Influence of the time of flight information on the reconstruction of in-beam PET data". Paper presented in 2007 IEEE NSS/MIC, 2007.
    10.1109/NSSMIC.2007.4437086
  32. Fiedler, F.; Crespo, P.; Parodi, K.; Sellesk, M.; Enghardt, W.. "The feasibility of in-beam PET for therapeutic beams of3He". Paper presented in 2005 IEEE NSS/MIC, 2005.
    10.1109/NSSMIC.2005.1596907
  33. Crespo, P.; Barthel, T.; Frais-Kölbl, H.; Griesmayer, E.; Heidel, K.; Parodi, K.; Pawelke, J.; Enghardt, W.. "Suppression of random coincidences during in-beam PET measurements". 2004.
  34. Crespo, P.; Kapusta, M.; Pawelke, J.; Moszynski, M.; Enghardt, W.. "First in-beam PET imaging with LSO/APD-array detectors". Paper presented in 2003 IEEE NSS/MIC, 2003.
    10.1109/nssmic.2003.1352251
  35. Kapusta, M.; Crespo, P.; Moszynski, M.; Enghardt, W.; Szawlowski, M.; Zhou, B.L.; Wolski, D.. "Evaluation of LAAPD arrays for high-resolution scintillator matrices readout". 2001.
  36. Lauckner, K.; Crespo, P.; Enghardt, W.; Pawelke, J.; Kraft, G.. "An LSO-based scanner for in-beam PET: A feasibility study". Paper presented in 2000 IEEE NSS/MIC, 2000.
  37. Crespo, P.; van der Marel, J.; Chepel, V.; Lopes, M.I.; Santos, Dinis; Janeiro, L.; Solovov, V.; Ferreira Marques, R.; Policarpo, A.J.P.L.. "Pulse processing for the PET liquid xenon multiwire ionisation chamber". Paper presented in 2008 IEEE NSS/MIC, 1998.
Journal article
  1. Abouzahr, F; Cesar, J P; Crespo, P; Gajda, M; Hu, Z; Klein, K; Kuo, A S; et al. "The first probe of a FLASH proton beam by PET". Physics in Medicine & Biology 68 23 (2023): 235004. http://dx.doi.org/10.1088/1361-6560/ad0901.
    Published • 10.1088/1361-6560/ad0901
  2. Abouzahr, F; Cesar, J P; Crespo, P; Gajda, M; Hu, Z; Kaye, W; Klein, K; et al. "The first PET glimpse of a proton FLASH beam". Physics in Medicine & Biology 68 12 (2023): 125001. http://dx.doi.org/10.1088/1361-6560/acd29e.
    Published • 10.1088/1361-6560/acd29e
  3. Fonte, Paulo; Lopes, Luís; Alves, Rui; Carolino, Nuno; Crespo, Paulo; Couceiro, Miguel; Cunha, Orlando; et al. Corresponding author: Fonte, Paulo. "An RPC-PET brain scanner demonstrator: First results". Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 1051 (2023): 168236. http://dx.doi.org/10.1016/j.nima.2023.168236.
    Published • 10.1016/j.nima.2023.168236
  4. Morozov, A.; Simões, H.; Crespo, P.. "Distal edge determination precision for a multi-slat prompt-gamma camera: A comprehensive simulation and optimization of the detection system". Physica Medica 84 (2021): 85-100. http://dx.doi.org/10.1016/j.ejmp.2021.03.028.
    Published • 10.1016/j.ejmp.2021.03.028
  5. M. P. Pascoa; J. M. Maia; N. Auricchio; R. M. Curado da Silva; P. Crespo; S. J. C. do Carmo; M. Moita; F. Alves; E. Caroli. "Orbit-Like Proton Radiation Sensitivity of CdTe Detectors: Evaluation of Mobility-Lifetime Products and Spectroscopic Properties". IEEE Transactions on Nuclear Science 66 9 (2019): 2063-2071. https://doi.org/10.1109/TNS.2019.2935119.
    10.1109/TNS.2019.2935119
  6. Patricia Cambraia Lopes; Paulo Crespo; Jan Huizenga; Dennis R. Schaart. "Optimization of the Signal-to-Background Ratio in Prompt Gamma Imaging Using Energy and Shifting Time-of-Flight Discrimination: Experiments With a Scanning Parallel-Slit Collimator". IEEE Transactions on Radiation and Plasma Medical Sciences 2 5 (2018): 510-519. https://doi.org/10.1109/TRPMS.2018.2846612.
    10.1109/TRPMS.2018.2846612
  7. Simões, N.; Maia, J.M.; Curado da Silva, R.M.; Ghithan, S.; Crespo, P.; do Carmo, S.J.C.; Alves, F.; et al. "Inflight proton activation and damage on a CdTe detection plane". Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 877 (2018): 183-191. http://www.scopus.com/inward/record.url?eid=2-s2.0-85031724999&partnerID=MN8TOARS.
    10.1016/j.nima.2017.09.017
  8. Cambraia Lopes, P.; Crespo, P.; Simões, H.; Ferreira Marques, R.; Parodi, K.; Schaart, D.R.. "Simulation of proton range monitoring in an anthropomorphic phantom using multi-slat collimators and time-of-flight detection of prompt-gamma quanta". Physica Medica 54 (2018): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-85053369756&partnerID=MN8TOARS.
    10.1016/j.ejmp.2018.09.001
  9. Simoes, Hugo; Lopes, Ana Luisa; Travassos, Carolina; Crespo, Paulo; Barros, Mariana Alves; Lencart, Joana; Rachinhas, Paulo J. B. M.; Santos, Joao A. M.. "Monitoring Tumor Lung Irradiation With Megavoltage Patient-Scattered Radiation: A Full System Simulation Study". IEEE Transactions on Radiation and Plasma Medical Sciences 1 5 (2017): 452-459. http://dx.doi.org/10.1109/trpms.2017.2724139.
    Published • 10.1109/trpms.2017.2724139
  10. Lopes, Ana Luísa; Simões, Hugo; Travassos, Carolina; Crespo, Paulo. "Patient Compton Scattered Radiation for Monitoring Prostate Radiotherapy with Gold Fiducial Markers: A Simulation Study". International Journal of Pharma Medicine and Biological Sciences 6 3 (2017): 77-82. http://dx.doi.org/10.18178/ijpmbs.6.3.77-82.
    10.18178/ijpmbs.6.3.77-82
  11. Cambraia Lopes, P.; Bauer, J.; Salomon, A.; Rinaldi, I.; Tabacchini, V.; Tessonnier, T.; Crespo, P.; Parodi, K.; Schaart, D.R.. "First in situ TOF-PET study using digital photon counters for proton range verification". Physics in Medicine and Biology 61 16 (2016): 6203-6230. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983749015&partnerID=MN8TOARS.
    10.1088/0031-9155/61/16/6203
  12. Ghithan, Sharif; Crespo, Paulo; Carmo, S.J.C. do; Marques, Rui Ferreira; Fraga, F.A.F.; Simões, Hugo; Alves, Francisco; Rachinhas, P.J.B.M.. "Development of a PET cyclotron based irradiation setup for proton radiobiology". Journal of Instrumentation 10 02 (2015): P02010-P02010. http://dx.doi.org/10.1088/1748-0221/10/02/p02010.
    10.1088/1748-0221/10/02/p02010
  13. Couceiro, M.; Crespo, P.; Blanco, A.; Ferreira, N.C.; Mendes, L.; Ferreira Marques, R.; Fonte, P.. "Time-of-flight positron emission tomography with resistive plate chamber detectors: An unlikely but promising approach". Acta Physica Polonica A 127 5 (2015): 1453-1461. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930436662&partnerID=MN8TOARS.
    10.12693/APhysPolA.127.1453
  14. Cambraia Lopes, P.; Clementel, E.; Crespo, P.; Henrotin, S.; Huizenga, J.; Janssens, G.; Parodi, K.; et al. "Time-resolved imaging of prompt-gamma rays for proton range verification using a knife-edge slit camera based on digital photon counters". Physics in Medicine and Biology 60 15 (2015): 6063-6085. http://www.scopus.com/inward/record.url?eid=2-s2.0-84930949034&partnerID=MN8TOARS.
    10.1088/0031-9155/60/15/6063
  15. Martins, P.; Blanco, A.; Crespo, P.; Marques, M.F.F.; Marques, R.F.; Gordo, P.M.; Kajetanowicz, M.; et al. "Towards very high resolution RPC-PET for small animals". Journal of Instrumentation 9 10 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84908500888&partnerID=MN8TOARS.
    10.1088/1748-0221/9/10/C10012
  16. Couceiro, M.; Crespo, P.; Marques, R.F.; Fonte, P.. "Scatter fraction, count rates, and noise equivalent count rate of a single-bed position RPC TOF-PET system assessed by simulations following the NEMA NU2-2001 standards". IEEE Transactions on Nuclear Science 61 3 (2014): 1153-1163. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903313773&partnerID=MN8TOARS.
    10.1109/TNS.2014.2303654
  17. Crespo, Paulo. "Resistive plate chambers in positron emission tomography". (2013): http://dx.doi.org/10.1140/epjp/i2013-13073-5.
    10.1140/epjp/i2013-13073-5
  18. Ghithan, S.; Do Carmo, S.J.C.; Ferreira Marques, R.; Fraga, F.A.F.; Simões, H.; Alves, F.; Crespo, P.. "On-line measurements of proton beam current from a PET cyclotron using a thin aluminum foil". Journal of Instrumentation 8 7 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84881131036&partnerID=MN8TOARS.
    10.1088/1748-0221/8/07/P07010
  19. Cunha, M.; Pinto, M.; Simoes, H.; Ferreira, B.; Do Carmo Lopes, M.; Fonte, P.; Crespo, P.. "Dose-free monitoring of radiotherapy treatments with scattered photons: Concept and simulation study". IEEE Transactions on Nuclear Science 60 4 (2013): 3119-3126. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882865737&partnerID=MN8TOARS.
    10.1109/TNS.2013.2265159
  20. Simoes, H.; Cunha, M.; Pinto, M.; Goncalves, J.; Sampaio, L.; Ferreira, R.J.; Saraiva, H.M.; et al. "Dose-free monitoring of radiotherapy treatments with scattered photons: First experimental results at a 6-MV linac". IEEE Transactions on Nuclear Science 60 4 (2013): 3110-3118. http://www.scopus.com/inward/record.url?eid=2-s2.0-84882906994&partnerID=MN8TOARS.
    10.1109/TNS.2013.2265137
  21. Biegun, A.K.; Seravalli, E.; Lopes, P.C.; Rinaldi, I.; Pinto, M.; Oxley, D.C.; Dendooven, P.; et al. "Time-of-flight neutron rejection to improve prompt gamma imaging for proton range verification: A simulation study". Physics in Medicine and Biology 57 20 (2012): 6429-6444. http://www.scopus.com/inward/record.url?eid=2-s2.0-84867280532&partnerID=MN8TOARS.
    10.1088/0031-9155/57/20/6429
  22. Crespo, P.; Reis, J.; Couceiro, M.; Blanco, A.; Ferreira, N.C.; Marques, R.F.; Martins, P.; Fonte, P.. "Whole-body single-bed time-of-flight RPC-PET: Simulation of axial and planar sensitivities with NEMA and anthropomorphic phantoms". IEEE Transactions on Nuclear Science 59 3 PART 1 (2012): 520-529. http://www.scopus.com/inward/record.url?eid=2-s2.0-84862597137&partnerID=MN8TOARS.
    10.1109/TNS.2012.2182677
  23. Couceiro, M.; Crespo, P.; Mendes, L.; Ferreira, N.; Ferreira Marques, R.; Fonte, P.. "Spatial resolution of human RPC-PET system". Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 661 SUPPL. 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-83955164365&partnerID=MN8TOARS.
    10.1016/j.nima.2010.07.078
  24. Fiedler, F.; Shakirin, G.; Skowron, J.; Braess, H.; Crespo, P.; Kunath, D.; Pawelke, J.; Pönisch, F.; Enghardt, W.. "On the effectiveness of ion range determination from in-beam PET data". Physics in Medicine and Biology 55 7 (2010): 1989-1998. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949705429&partnerID=MN8TOARS.
    10.1088/0031-9155/55/7/013
  25. Makinaga, A.; Schwengner, R.; Rusev, G.; Dönau, F.; Frauendorf, S.; Bemmerer, D.; Beyer, R.; et al. "Dipole strength in La139 below the neutron-separation energy". Physical Review C - Nuclear Physics 82 2 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956168603&partnerID=MN8TOARS.
    10.1103/PhysRevC.82.024314
  26. Blanco, A.; Couceiro, M.; Crespo, P.; Ferreira, N.C.; Ferreira Marques, R.; Fonte, P.; Lopes, L.; Neves, J.A.. "Efficiency of RPC detectors for whole-body human TOF-PET". Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 602 3 (2009): 780-783. http://www.scopus.com/inward/record.url?eid=2-s2.0-64349107909&partnerID=MN8TOARS.
    10.1016/j.nima.2008.12.134
  27. Fiedler, F.; Priegnitz, M.; Julich, R.; Pawelke, J.; Crespo, P.; Parodi, K.; Pönisch, F.; Enghardt, W.. "In-beam PET measurements of biological half-lives of 12C irradiation induced ß+-activity". Acta Oncologica 47 6 (2008): 1077-1086. http://www.scopus.com/inward/record.url?eid=2-s2.0-51149093939&partnerID=MN8TOARS.
    10.1080/02841860701769743
  28. Nair, C.; Junghans, A.R.; Erhard, M.; Bemmerer, D.; Beyer, R.; Crespo, P.; Grosse, E.; et al. "Photodisintegration studies on p-nuclei: The case of Mo and sm isotopes". Journal of Physics G: Nuclear and Particle Physics 35 1 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-38849110789&partnerID=MN8TOARS.
    10.1088/0954-3899/35/1/014036
  29. Shakirin, Georgy; Crespo, Paulo; Enghardt, Wolfgang. "A Method for System Matrix Construction and Processing for Reconstruction of In-Beam PET Data". IEEE Transactions on Nuclear Science 54 5 (2007): 1710-1716. http://dx.doi.org/10.1109/tns.2007.906161.
    10.1109/tns.2007.906161
  30. Crespo, P.; Shakirin, G.; Fiedler, F.; Enghardt, W.; Wagner, A.. "Direct time-of-flight for quantitative, real-time in-beam PET: A concept and feasibility study". Physics in Medicine and Biology 52 23 (2007): 6795-6811. http://www.scopus.com/inward/record.url?eid=2-s2.0-36348936173&partnerID=MN8TOARS.
    10.1088/0031-9155/52/23/002
  31. Fiedler, F.; Crespo, P.; Parodi, K.; Sellesk, M.; Enghardt, W.. "The feasibility of in-beam PET for therapeutic beams of3He". IEEE Transactions on Nuclear Science 53 4 (2006): 2252-2259. http://www.scopus.com/inward/record.url?eid=2-s2.0-33748348422&partnerID=MN8TOARS.
    10.1109/TNS.2006.877854
  32. Crespo, P.; Shakirin, G.; Enghardt, W.. "On the detector arrangement for in-beam PET for hadron therapy monitoring". Physics in Medicine and Biology 51 9 (2006): 2143-2163. http://www.scopus.com/inward/record.url?eid=2-s2.0-33645990582&partnerID=MN8TOARS.
    10.1088/0031-9155/51/9/002
  33. Crespo, P.; Barthel, T.; Frais-Kölbl, H.; Griesmayer, E.; Heidel, K.; Parodi, K.; Pawelke, J.; Enghardt, W.. "Suppression of random coincidences during in-beam PET measurements at ion beam radiotherapy facilities". IEEE Transactions on Nuclear Science 52 4 (2005): 980-987. http://www.scopus.com/inward/record.url?eid=2-s2.0-27644529469&partnerID=MN8TOARS.
    10.1109/TNS.2005.852637
  34. Parodi, K.; Crespo, P.; Eickhoff, H.; Haberer, T.; Pawelke, J.; Schardt, D.; Enghardt, W.. "Random coincidences during in-beam PET measurements at microbunched therapeutic ion beams". Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 545 1-2 (2005): 446-458. http://www.scopus.com/inward/record.url?eid=2-s2.0-19044397899&partnerID=MN8TOARS.
    10.1016/j.nima.2005.02.002
  35. Enghardt, W.; Parodi, K.; Crespo, P.; Fiedler, F.; Pawelke, J.; Pönisch, F.. "Dose quantification from in-beam positron emission tomography". Radiotherapy and Oncology 73 SUPPL. 2 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-21444447195&partnerID=MN8TOARS.
  36. Crespo, P.; Kapusta, M.; Pawelke, J.; Moszynski, M.; Enghardt, W.. "First in-beam PET imaging with LSO/APD array detectors". IEEE Transactions on Nuclear Science 51 5 II (2004): 2654-2661. http://www.scopus.com/inward/record.url?eid=2-s2.0-8344224625&partnerID=MN8TOARS.
    10.1109/TNS.2004.835780
  37. Kapusta, M.; Crespo, P.; Wolski, D.; Heidel, K.; Heinrich, L.; Hutsch, J.; Pawelke, J.; et al. "The LSO/APD array as a possible detector for in-beam PET in hadron therapy". IEEE Transactions on Nuclear Science 51 4 I (2004): 1389-1394. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444361289&partnerID=MN8TOARS.
    10.1109/TNS.2004.832318
  38. Enghardt, W.; Crespo, P.; Fiedler, F.; Hinz, R.; Parodi, K.; Pawelke, J.; Pönisch, F.. "Charged hadron tumour therapy monitoring by means of PET". Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 525 1-2 (2004): 284-288. http://www.scopus.com/inward/record.url?eid=2-s2.0-3342974692&partnerID=MN8TOARS.
    10.1016/j.nima.2004.03.128
  39. Kapusta, M.; Crespo, P.; Wolski, D.; Moszynski, M.; Enghardt, W.. "Hamamatsu S8550 APD arrays for high-resolution scintillator matrices readout". Nuclear Instruments and Methods in Physics Research, Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 504 1-3 (2003): 139-142. http://www.scopus.com/inward/record.url?eid=2-s2.0-0038521578&partnerID=MN8TOARS.
    10.1016/S0168-9002(03)00809-X
  40. Crespo, Paulo. "The alpha magnetic spectrometer (AMS)". Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment 478 1–2 (2002): 119-122. http://dx.doi.org/10.1016/S0168-9002(01)01727-2.
    10.1016/S0168-9002(01)01727-2
  41. Kapusta, M.; Crespo, P.; Moszynski, M.; Enghardt, W.; Szawlowski, M.; Zhou, B.L.; Wolski, D.. "Evaluation of LAAPD arrays for high-resolution scintillator matrices readout". IEEE Transactions on Nuclear Science 49 I 4 (2002): 1693-1698. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036702940&partnerID=MN8TOARS.
    10.1109/TNS.2002.801667
  42. Crespo, P.; Debus, J.; Enghardt, W.; Haberer, Th.; Jäkel, O.; Krämer, M.; Kraft, G.. "Tumor therapy with carbon ion beams". Physica Medica 17 SUPPL. 4 (2001): 1-3. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035571486&partnerID=MN8TOARS.
  43. Crespo, Paulo. "Cosmic protons". Physics Letters B 490 1–2 (2000): 27-35. http://dx.doi.org/10.1016/S0370-2693(00)00970-9.
    10.1016/S0370-2693(00)00970-9
  44. Crespo, Paulo. "Leptons in near earth orbit". Physics Letters B 484 1–2 (2000): 10-22. http://dx.doi.org/10.1016/S0370-2693(00)00588-8.
    10.1016/S0370-2693(00)00588-8
  45. Crespo, Paulo. "Protons in near earth orbit". Physics Letters B 472 1–2 (2000): 215-226. http://dx.doi.org/10.1016/S0370-2693(99)01427-6.
    10.1016/S0370-2693(99)01427-6
  46. Crespo, P.; Van Der Marel, J.; Chepel, V.; Lopes, M.I.; Santos, D.; Janeiro, L.; Solovov, V.; Ferreira Marques, R.; Policarpo, A.J.P.L.. "Pulse processing for the PET liquid xenon multiwire ionisation chamber". IEEE Transactions on Nuclear Science 47 6 II (2000): 2119-2126. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034450512&partnerID=MN8TOARS.
    10.1109/23.903858
  47. Crespo, Paulo. "Search for antihelium in cosmic rays". Physics Letters B 461 4 (1999): 387-396. http://dx.doi.org/10.1016/S0370-2693(99)00874-6.
    10.1016/S0370-2693(99)00874-6
  48. Chepel, V.; Solovov, V.; van der Marel, J.; Lopes, M.I.; Crespo, P.; Janeiro, L.; Santos, Dinis; Marques, R.Ferreira; Policarpo, A.J.P.L.. "Liquid xenon detector for PET: recent results". IEEE Nuclear Science Symposium and Medical Imaging Conference 3 (1999): 1426-1432. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032597040&partnerID=MN8TOARS.
  49. Crespo, P.; Chepel, V.; Lopes, M.I.; Janeiro, L.. "Pulse shape analysis in the liquid xenon multiwire ionisation chamber for pet1". IEEE Transactions on Nuclear Science 45 3 PART 1 (1998): 561-567. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032097460&partnerID=MN8TOARS.

Intellectual property

Patent
  1. Crespo, Paulo; Heidel, K.; Enghardt, W.; Fiedler, F.. Corresponding author: Crespo, Paulo. 2006. "Verfahren zur Kontrolle von Bestrahlungen an Bestrahlungseinrichtungen mit in-beam Positronenemissionstomographen". Germany.
    Granted/Issued
  2. Crespo, Paulo; Enghardt, W.; Parodi, K.; Pawelke, J.. Corresponding author: Enghardt, W.. 2004. "Verfahren zur Korrektur der beim Monitoring der strahlentherapeutischen Behandlung mittels in-beam Positronen-Emissions-Tomographie erhaltenen Messwerte". Germany.
    Granted/Issued
Distinctions

Other distinction

2006 Top 10 article of the year in Physics in Medicine and Biology according to the reviewers
IOP - Institute of Physics, United Kingdom