???global.info.a_carregar???
Rita Daniela Santos Matos. In 2014, I obtained an MSc degree in Molecular and Cellular Biology, after a BSc in Biochemistry, both from University of Porto. In 2016, I joined the Glycobiology in Cancer Group at i3S, where I have been the opportunity to work in a multidisciplinary team focused on the role of glycans on multiple pathological conditions, such as gastrointestinal cancer and infectious diseases (M. tuberculosis. In 2017, I started my PhD studies (Pathology and Molecular Genetics Doctoral Programme, University of Porto) under a collaboration with Ghent University, Belgium. During my international PhD studies, I characterized the adhesion and pathogenicity mechanisms of gastric non-Helicobacter pylori Helicobacter (NHPH) species to adhere to the human gastric mucosa. I demonstrated for the first time the in vitro adhesion of these bacteria to human gastric tissues. I was also focused on the acquisition of antibiotic resistance and efficacy of current Helicobacter eradication treatment. I have a solid publication track record with a total of 14 publications on international indexed journals (7 as first author).
Read full resume ↓
Identification

Personal identification

Full name
Rita Daniela Santos Matos

Citation names

  • Matos, Rita

Author identifiers

Ciência ID
DE1A-3D9C-1A11
ORCID iD
0000-0002-9186-3711

Knowledge fields

  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2017/10/01 - 2022/01/28
Concluded
 Patologia e Genética Molecular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Characterization of the pathogenicity and adhesion mechanisms of non-Helicobacter pylori Helicobacters (NHPH) in humans " (THESIS/DISSERTATION)
2016 - 2016
Concluded
 VI Workshop on Cancer Research - Biological and Molecular Basis (Curso médio)
Universidade do Porto, Portugal
2014 - 2014
Concluded
 Curso de Ciência em Animais de Laboratorio (Cat C) - FELASA (Curso médio)
Universidade do Porto Faculdade de Medicina, Portugal
2012 - 2014
Concluded
 Mestrado em Biologia Celular e Molecular (Mestrado)
Universidade do Porto, Portugal
"Characterization of an animal model of bladder painful syndrome/ Interstitial cystitis" (THESIS/DISSERTATION)
 17
2013 - 2013
Concluded
 Contention, Handling, Collect and Parenteral Administation in Rodents (Curso médio)
Universidade do Porto Faculdade de Medicina, Portugal
2009 - 2012
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto, Portugal
"Avaliação de mosaicismo de baixo grau pela técnica de Hibridação in situ de Fluorescência" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2022/05/01 - Current Research Assistant (Research) Instituto de Investigação e Inovação em Saúde, Portugal
Instituto de Investigação e Inovação em Saúde, Portugal

Others

Category
Host institution 		Employer
2017/10/01 - 2022/01/28 Doutoramento Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016/05/01 - 2017/09/30 Bolseiro de Investigação Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/04/01 - 2015/05/01 Master Degree in Celullar and Molecular Biology in Departamento de Biologia Experimental da faculdade de Medicina da Universidade do Porto Universidade do Porto Faculdade de Medicina, Portugal
2011/09/01 - 2012/06/01 Estágio de licenciatura em Bioquímica (Serviço de Genética, FMUP) Universidade do Porto Faculdade de Medicina, Portugal
Projects

Contract

Designation Funders
2019/04/01 - Current Passive immunotherapy against gastric cancer
CAR16
Research Fellow
Umea Universitet, Sweden
Ongoing
2018/10/01 - 2022/06/30 GLYCANTIGENS .: Glicoantigénios da proteina MUC1: Um perspectiva estructural na luta contra o cancro
POCI-01-0145-FEDER-031028
Research Fellow
Concluded
2016/05/01 - 2020/03/31 Glicoengenharia celular para a avaliação das modificações pós-traducionais dos receptores celulares no cancro
PTDC/BBB-EBI/0567/2014
Research Fellow
IPATIMUP/ i3S, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2013/04 - 2015/02 Biomarkers and mechanisms of interstitial cystitis
EXPL_NEU-SSC_0288_2013
Master Student Fellow
Universidade do Porto Faculdade de Medicina, Portugal
Concluded
Outputs

Publications

Conference abstract
  1. Matos, R.; Cordeiro, J. M.; Igawa, Y.; Cruz, CD; Charrua, A.. "Bladder pain in BPS/IC may result from exaggerated response of TRPV1 and enhanced urothelial ATP release induced by chronic adrenergic overactivity". Paper presented in 45th Annual Meeting of the International Continence Society (ICS), Montrel, Canada, 2015.
    Published
  2. Charrua, A.; Matos, R.; Marczylo, T; Nagy, I; Cruz, CD. "Fatty Acid Amide Hydrolase inhibitor improves function of inflamed bladders by simultaneous modulation of anandamide and palmitolyethanolamide levels". Paper presented in 45th Annual Meeting of the International Continence Society (ICS), Montreal, 2015.
    Published
Conference poster
  1. Matos, Rita Daniela Santos. "Adrenergic Overactivity obduces bladder pain and hyperactivity by increasing TRPV1 excitability". Paper presented in 16th International European Association of Urology (EAU) Meeting, 2015.
  2. Matos, Rita Daniela Santos. "Characterization of an animal model of bladder pain syndrome/ interstitial cystitis". Paper presented in 4th i3S Annual Meeting, 2014.
Journal article
  1. Rita Matos; Hugo Santos Sousa; Jorge Nogueiro; Ana Magalhães; Celso A. Reis; Fátima Carneiro; Irina Amorim; Freddy Haesebrouck; Fátima Gärtner. "Helicobacter species binding to the human gastric mucosa". Helicobacter (2022): https://doi.org/10.1111/hel.12867.
    10.1111/hel.12867
  2. Rita Matos; Emily Taillieu; Sofie De Bruyckere; Chloë De Witte; Alexandra Rêma; Hugo Santos-Sousa; Jorge Nogueiro; et al. "Presence of Helicobacter Species in Gastric Mucosa of Human Patients and Outcome of Helicobacter Eradication Treatment". Journal of Personalized Medicine 12 2 (2022): 181-181. https://doi.org/10.3390/jpm12020181.
    10.3390/jpm12020181
  3. Ana Salomé Correia; Rita Matos; Fátima Gärtner; Irina Amorim; Nuno Vale. "High Drug Resistance in Feline Mammary Carcinoma Cell Line (FMCm) and Comparison with Human Breast Cancer Cell Line (MCF-7)". Animals (2021): https://doi.org/10.3390/ani11082321.
    10.3390/ani11082321
  4. Bárbara Costa; Rita Matos; Irina Amorim; Fátima Gärtner; Nuno Vale. "New Insight into Breast Cancer Cells Involving Drug Combinations for Dopamine and Serotonin Receptors". Applied Sciences 11 13 (2021): 6082-6082. https://doi.org/10.3390/app11136082.
    10.3390/app11136082
  5. "Adhesion of Helicobacter Species to the Human Gastric Mucosa: A Deep Look Into Glycans Role". Frontiers in Molecular Biosciences 8 (2021): http://dx.doi.org/10.3389/fmolb.2021.656439.
    10.3389/fmolb.2021.656439
  6. Matos, Rita; Fonseca, Kaori L.; Mereiter, Stefan; Maceiras, Ana Raquel; Gomes, Joana; Vilaplana, Cristina; Gartner, Fátima; et al. "Mycobacterium tuberculosis Infection Up-Regulates Sialyl Lewis X Expression in the Lung Epithelium". Microorganisms 9 1 (2021): 99. http://dx.doi.org/10.3390/microorganisms9010099.
    Published • 10.3390/microorganisms9010099
  7. Rita Matos; Chloë De Witte; Annemieke Smet; Helena Berlamont; Sofie De Bruyckere; Irina Amorim; Fátima Gärtner; Freddy Haesebrouck. "Antimicrobial Susceptibility Pattern of Helicobacter heilmannii and Helicobacter ailurogastricus Isolates". Microorganisms 8 6 (2020): 957-957. https://doi.org/10.3390/microorganisms8060957.
    10.3390/microorganisms8060957
  8. Fonseca, Kaori L.; Maceiras, Ana Raquel; Matos, Rita; Simoes-Costa, Luisa; Sousa, Jeremy; Cá, Baltazar; Barros, Leandro; et al. "Deficiency in the glycosyltransferase Gcnt1 increases susceptibility to tuberculosis through a mechanism involving neutrophils". Mucosal Immunology (2020): http://dx.doi.org/10.1038/s41385-020-0277-7.
    Published • 10.1038/s41385-020-0277-7
  9. AR, Flores; I, Amorim; AR, Caseiro; SS, Pedrosa; M, Franca; A, Rema; R, Matos; et al. "Characterization of a short-term culture from a canine diffuse gastric carcinoma". Journal of Translational Science 6 1 (2020): http://dx.doi.org/10.15761/jts.1000315.
    Published • 10.15761/jts.1000315
  10. Charrua, Ana; Matos, Rita; Oliveira, Raquel; Marczylo, Tim; Nagy, Istvan; Cruz, Francisco. "Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats". Naunyn-Schmiedeberg's Archives of Pharmacology (2019): http://dx.doi.org/10.1007/s00210-019-01729-9.
    Published • 10.1007/s00210-019-01729-9
  11. Freitas, Daniela; Campos, Diana; Gomes, Joana; Pinto, Filipe; Macedo, Joana A.; Matos, Rita; Mereiter, Stefan; et al. "O-glycans truncation modulates gastric cancer cell signaling and transcription leading to a more aggressive phenotype". EBioMedicine 40 (2019): 349-362. http://dx.doi.org/10.1016/j.ebiom.2019.01.017.
    Published • 10.1016/j.ebiom.2019.01.017 • Assistant staff
  12. Matos, Rita; Serrão, Paula; Rodriguez, Larissa; Birder, Lori Ann; Cruz, Francisco; Charrua, Ana. "The water avoidance stress induces bladder pain due to a prolonged alpha1A adrenoceptor stimulation". Naunyn-Schmiedeberg's Archives of Pharmacology 0 (2017):
    Accepted • 10.1007/s00210-017-1384-1
  13. Matos, R.; Cordeiro, J. M.; Coelho, A.; Ferreira, S.; Silva, C.; Igawa, Y.; Cruz, F.; Charrua, A.. "Bladder pain induced by prolonged peripheral alpha 1A adrenoceptor stimulation involves the enhancement of transient receptor potential vanilloid 1 activity and an increase of urothelial adenosine triphosphate release". Acta Physiologica 218 4 (2016): 265-275.
    Published • 10.1111/apha.12744
Magazine article
  1. Charrua, A.; Matos, R.; Serrao, P; Cruz, CD. "Bladder pain induced in rats by chronic stress is mediated by prolonged stimulation of alpha 1A adrenoceptor", Neurourology and Urodynamics, 2016
  2. Charrua, A.; Matos, R.; Marczylo, T; Nagy, I; Cruz, F.. "Measurement of endocannabinoids levels during treatment of bladder hyperactivity induced by cystitis with FAAH inhibitors and evaluation of the cannabinoid receptor and TRPV1 roles", Eur Uro Suppl, 2016
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11/29 Antimicrobial Susceptibility Pattern of Helicobacter spp. i3S Annual Meeting
2019/09/06 Host glycosylation affects Mycobacterium tuberculosis infection GLUPOR13
IPATIMUP/ i3S (Porto, Portugal)
2015 TRPV1 as a new target to treat bladder pain syndrome/ interstitial cystitis XLV Meeting of Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Lisboa, Portugal, Portugal)
2014 Alpha 1A adrenoceptor antagonist suppresses bladder pain and urothelial disruption in a model of bladder pain syndome/ interstitial cystitis 7th Meeting of Young Researchers of University of Porto (IJUP)
Universidade do Porto (Porto, Portugal)
2014 Alpha 1A adrenoceptor antagonist suppresses bladder pain and urothelial disruption in a model of bladder pain syndrome/ interstitial cystitis XLIV Meeting of Portuguese Society of Pharmacology
Portuguese Society of Pharmacology (Coimbra, Portugal, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2021/11/30 - Current Organization of the 4th i3S PhDay: Break borders and build opportunities (2021/11/30)
Congress (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2018/07/04 - 2018/07/07 13th International Workshop on Pathogenesis and Host Response in Helicobacter infection
Congress
 Workshop
2016 - 2016 Orchestrating life, from molecules to cells
Symposium
 2nd Annual MCBiology Symposium (17th November 2016)
2016 - 2016 Breaking Boundaries in Sciences
Symposium
 16th GABBA Annual Symposium (15th July 2016)
GABBA, Portugal
2016 - 2016 Emerging Technologies in Health Sciences
Symposium
 3rd Annual BiotechHealth Symposium (21st June 2016)
Biotech Health Doctoral Programme, Portugal
2016 - 2016 VI Workshop on Cancer Research - Biological and Molecular Basis
Workshop
 VI Workshop on Cancer Research - Biological and Molecular Basis (10th at 13th May 2016)
IPATIMUP/ i3S, Portugal
2009 - 2009 Meeting for Education and Dissemination of Biochemistry
Meeting
 Meeting for Education and Dissemination of Biochemistry (18th December 2009)

Committee member

Activity description
Role 		Institution / Organization
2018/04/11 - 2021/12/09 Membro da Comissão de Acompanhamento do Programa Doutoral em Patologia e Genética Molecular (ICBAS-UP)
Member
 Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020/11/01 - 2021/10/30 Membro Integrante dos Representantes dos Alunos de Doutoramento do i3S - 2020/2021
Member
 Instituto de Investigação e Inovação em Saúde, Portugal
Distinctions

Other distinction

2016 Bolsa de Investigaçao
IPATIMUP/ i3S, Portugal
2008 Bolsa de Estudo por Mérito Escolar
Escola Secundaria de Paços de Ferreira, Portugal
2007 Bolsa de Estudo por Mérito Escolar
Escola Secundaria de Paços de Ferreira, Portugal
2006 Bolsa de Estudo por Mérito Escolar
Escola Secundaria de Paços de Ferreira, Portugal
2005 Prémio de Mérito Escolar
Escola EB 2,3 de Frazao e UNiversidade do Porto, Portugal