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My scientific path began with a Bachelor in Biochemistry (FCUP, Porto, 2003) and an ERASMUS training at Wageninen University (The Netherlands). In 2004, I started my Breast cancer (BC) Oncobiology training in the most renowned cancer research institute in Portugal (IPATIMUP), completing a Master in Molecular Oncology (2006), and a PhD in Biomedicine (FMUP, Porto, 2011), with the supervision of Fernando Schmitt (one of the world's best BC pathologist experts) and Joana Paredes (an internationally recognized researcher on BC invasion and metastasis). I was top ranked in a highly competitive post-doc grant (7/151 applicants) to unravel the molecular mechanisms behind the impact of P-cadherin on BC cell invasion and metastases. I acquired EXTENSIVE TRAINING in EXTERNAL RENOWNED INSTITUTIONS, namely in Uppsala University (SWEDEN, 2010) and at IMM (Lisbon, 2014). This was crucial for the acquisition of new scientific knowledge and new front-line methodologies that were further implemented at IPATIMUP/i3s, resulting in 3 peer-reviewed publications. I also collaborated with more than 30 national/international research groups, significantly contributing to 15 multidisciplinary collaborative papers, reflecting my scientific and technical expertise in BC. From 2011 to 2016, I had 3 maternity leaves to support the first 6 months of my babies’ growth. Although this has slowed down my lab work, it gave me the opportunity to strengthen my mentoring, writing and leadership capacity. Therefore, in 2017, I established a novel RESEARCH LINE in the group, focused on secreted prognostic biomarkers for metastatic BC, since it is the main cause of BC related-death. I have been particularly focused on BC brain metastasis and, in this context, I have developed a novel in vivo tool to study cancer stem cells and defined a brain BC stem cell signature that significantly predicts a worse prognosis for BC patients. I have also been developing 2D and 3D in vitro assays, ex-vivo organotypic cultures and several in vivo tools (e.g. chicken choriallantoic and mice) to overcome the lack of metastasis experimental models. Of relevance, my data has been crucial to attract funding in competitive calls for several projects where I have been involved in the coordination and supervision as PI, co-PI and task leader to advance on cancer metastasis, totaling >500K€, as well as for 5 projects (>3M€) where I integrate as a team member. Recently, I was awarded with two Innovation prizes for the development of a novel clinical tool to screen for metastatic predictive biomarkers that had mediatic projection with TV and journal interviews. Currently, I am an Assistant Researcher with a strong track record in BC. I am the most senior member of the team from the recently formed Cancer Metastasis group at i3S (2021), led by the young group leader Joana Paredes. My publication list includes 38 peer-reviewed papers (5 first and 1 last author) in Q1 journals (Oncogene, Hum Mol Gen, Lancet Oncol, Sem Can Biol, Nanoscale, J Pathol) and 4 book chapters, with a cumulative IF of 244.98, >1350 citations and h-index 21. My work has been awarded and selected for oral presentations at important international conferences and institutional seminars. I also lecture under the framework of Master and PhD programs, participate in thesis committees, and review for respected journals, also reflecting the recognition of my work by research fellows. I have mentored more than 17 students and participated in the hiring of new team members of the Cancer Metastasis group. I am also highly involved in several activities at i3S, namely as postdoc seminar organizer, science Ambassador within the i3S Educational program and member of the ORBEA (Animal Welfare and Ethics Body). Of note, I partner with patient advocates networks to ensure that my research integrates cancer patients’ perspective and that my findings are communicated back to the community. I am an active member of cancer societies in joined
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Identification

Personal identification

Full name
Ana Sofia Pais Ribeiro

Citation names

  • Ribeiro, Ana Sofia
  • Ribeiro AS
  • Ribeiro A.S.

Author identifiers

Ciência ID
DE1F-4ECF-4EFF
ORCID iD
0000-0002-9698-9233
Researcher Id
J-7334-2013
Scopus Author Id
55937369200

Email addresses

  • anaspribeiro@gmail.com (Personal)

Knowledge fields

  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences
  • Medical and Health Sciences - Basic Medicine - Pathology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2011
Concluded
 Biomedicina (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"Does P-cadherin expression interfere with E-cadherin function in breast cancer cells?" (THESIS/DISSERTATION)
 Approved with distinction
2006
Concluded
 Oncologia molecular (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
"P-cadherin: Role in breast cancer cell migration and invasion" (THESIS/DISSERTATION)
 Approved by unanimity
2004/09/06
Concluded
 Biochemistry (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
""Oral Immunostimulation of juvenile carp"" (THESIS/DISSERTATION)
 14 valores
Affiliation

Science

Category
Host institution 		Employer
2019/01/01 - Current Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/01/01 - 2018/12/31 Contracted Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/01/01 - 2016/12/31 Postdoc (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Others

Category
Host institution 		Employer
2012/02/02 - 2016/12/31 POSITION: Pos-Doctoral researcher under a FCT grant and funded project GROUP: Joana Paredes Team in Cancer Genetics group ACTIVITIES:professional, supervision , scientific and technical activities of Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2014/01 - 2014/08 External Training period at IMM, under the supervision of Nuno C. Santos Instituto de Medicina Molecular, Portugal
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2008/01/01 - 2011/12/21 POSITION: PhD student under a FCT PhD Grant GROUP: Cancer Genetics Group, under the supervision of Fernando Schmitt and Joana Paredes. THESIS:Does P-cadherin expression interferes with E-cadherin func Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2010 - 2010 External Training period at Uppsala University, under the supervision of Ola Soderbergh Uppsala Universitet Rudbecklaboratoriet, Sweden
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005/07/01 - 2007/12/31 FCT research grant included in the project: "P-cadherin in breast cancer: what regulates its aberrant expression and how it can induce invasion of neoplastic cells?", under the supervision of Joana Pa Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005/01/01 - 2006/10/31 Master student with the project "P-cadherin: role in breast cancer cell migration and invasion", under supervision of Fernando Schmitt Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2003/03/01 - 2003/08/15 Trainning period included in the biochemistry degree, with the project "Oral immunostimulation of young carp", under the supervision of Jan Rombout and Heidi Huttenhuis Wageningen Universiteit, Netherlands
Projects

Grant

Designation Funders
2021/03/01 - 2024/02 Radiolabeled EXosomes - a nanotheranostic tool for lung micrometastasis in osteosarcoma
PTDC/BTM-SAL/4451/2020
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2021/10/01 - 2022/10 Cancer patient-derived secretome: a groundbreaking clinical tool to screen for metastatic predictive biomarkers
SECRET
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Liga Portuguesa Contra o Cancro Núcleo Regional do Norte
Concluded
2019 - 2022 BRAIN_METS - BRAIN METastaseS: uncovering the biomechanical crosstalk between cancer cells and the brain microenvironment
1
Co-Principal Investigator (Co-PI)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/06/01 - 2015/05/31 “Adhesion, Differentiation and Invasion: different processes, common cadherin players”, funded by FCT (PTDC/SAUGMG/120049/2010)
PTDC/SAUGMG/120049/2010
Post-doc Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded

Contract

Designation Funders
2019/03/15 - 2022/03 BRAIN_METS - BRAIN METastaseS: uncovering the biomechanical crosstalk between cancer cells and the brain microenvironment”, funded by FCT-P2020 (02/SAICT/2017-30625)
02/SAICT/2017-30625
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2017/01/01 - 2021/12/28 Tackling Cancer Stem Cells: a challenge and an opportunity to advance in anti-cancer therapy”, funded by FCT-P2020 (POCI-01-0145-FEDER-016390)
POCI-01-0145-FEDER-016390
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2017/01/01 - 2021/06/30 Tackling CANcer STEM CELls: a challenge and an opportunity to advance in anti-cancer therapy
SAICTPAC/0022/2015
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Instituto Nacional de Engenharia Biomédica, Portugal

Fundação Calouste Gulbenkian, Portugal

Universidade de Coimbra, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/05/01 - 2019/05/01 Advancing Cancer Research: from basic knowledge to application”, funded by NORTE 2020 (NORTE-01-0145-FEDER-000029)
NORTE-01-0145-FEDER-000029
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2014/06/01 - 2015/05/31 Dasatinib as an option to treat P-cadherin-overexpressing poor prognosis breast cancer”, funded by Associação Laço (Bolsa_LAÇO2014)
Bolsa_LAÇO2014
Post-doc Fellow
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Missão Laço
Concluded
2011 - 2014 Adhesion, Differentiation and Invasion: different processes, common cadherin players
SFRH / BPD /75705/2011
Post-doc
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/01/01 - 2013/06/30 A proteína bacteriana azurina: nova abordagem terapêutica para cancro da mama com mau prognóstico
PTDC/EBB-BIO/100326/2008
Universidade de Lisboa Instituto Superior Técnico, Portugal

Instituto de Biotecnologia e Bioengenharia, Portugal

Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Projecto Estratégico - LA 3 - 2011-2012
PEst-C/SAU/LA0003/2011
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2023/04 - 2023/05 An in vitro diagnostic tool to predict breast cancer metastatic risk
BIPAcceleration
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundación Banco Santander
Concluded
Outputs

Publications

Book chapter
  1. Sousa, Bárbara; Ribeiro, Ana Sofia; Paredes, Joana. "Heterogeneity and Plasticity of Breast Cancer Stem Cells". In Advances in Experimental Medicine and Biology, 83-103. Springer International Publishing, 2019.
    10.1007/978-3-030-14366-4_5
Conference abstract
  1. Carvalho, Rita; Cônde, Inês; Santos, Liliana; Leitão, Ricardo Alexandre; Gomes, Célia; Silva, Ana Paula; Paredes, Joana; et al. "Characterization of the secretome profile in brain metastic breast cancer cells". Paper presented in 2nd joint EACR-MRS conference - Seed and Soil: mechanisms of metastasis, Berlin, 2019.
    Published
Conference paper
  1. Ribeiro, Ana Sofia. "DECIPHERING THE SECRETOME SIGNATURE ENRICHED IN BREAST CANCER BRAIN METASTASIS". Paper presented in International Conference "Cancer Metastasis", Seefeld-in-Tirol, 2019.
  2. Ribeiro, Ana Sofia. "THE CROSSTALK BETWEEN STEM-LIKE CANCER CELLS AND THE TUMOUR MICROENVIRONMENT". Paper presented in SPCE-TC 2019 – 11th Edition of the International Meeting of the Portuguese Society for Stem Cells & Cell Therapies., Lisbon, 2019.
    Published
  3. Ribeiro, A.S.; Carvalho R; Oliveira M; Vieira AF; Paredes J. "Unraveling the impact of breast cancer cell`s matrisome in the preparation of the brain metastatic niche.". Paper presented in 1st Joint EACR-MRS Conference, Seed and Soil-In Vivo Models of Metastasis, Berlin, Germany, November 2017, Berlim, 2017.
    Published
  4. Ribeiro, AS. "P-cadherin activates Src-kinase: A new signaling pathway with implications in breast cancer progression". Paper presented in EACR, Barcelona, 2012.
  5. Bernardes, N.; Ribeiro, A.S.; Seruca, R.; Paredes, J.; Fialho, A.M.. "Bacterial protein azurin as a new candidate drug to treat untreatable breast cancers". 2011.
    10.1109/ENBENG.2011.6026047
  6. Ribeiro, A.S.. "Co-expression of E- and P-cadherin in breast cancer: suppressing or promoting cancer cell invasion?". Paper presented in EACR, Oslo, 2010.
    Published
  7. Paredes J; Ribeiro, A.S.; Schmitt F. "P-cadherin expression is involved in migration induction of MCF-7/AZ breast cancer cells". Paper presented in FEBS Congress, 2005.
    Published
Conference poster
  1. Conde, Inês; Carvalho, R.; Pinto, M.T.; Mendes, N.; Schmitt, F.; Ribeiro, Ana Sofia; Paredes, Joana. "Dissecting the role of PGRMC1 as a potential CSC biomarker associated with breast cancer metastasis". Paper presented in i3S PhDay, 2023.
  2. Conde, Inês; Carvalho, R.; Pinto, M.T.; Mendes, N.; Schmitt, F.; Ribeiro, Ana Sofia; Paredes, Joana. "Identificação do PGRMC1 como um biomarcador estaminal associado ao organotropismo metastático do cancro da mama". Paper presented in ENJIO LPCC-NRN, 2023.
  3. Castro, Maria Miguel ; Esquível, Catarina; Jesus, Tito T.; Ribeiro, Ana Sofia; Sousa, Bárbara; Jerónimo, Carmen; Paredes, Joana. "O impacto da perda de adesão célula-célula na sobrevivência de êmbolos tumorais de cancro da mama inflamatório". Paper presented in ENJIO 2023, Liga Portuguesa Contra o Cancro, 2023.
  4. Ferreira, Hugo R. S.; Tomatis, Francesca; Almeida, Sara F.F.; Ribeiro, Ana Sofia; Ferreira, Lino; Ana Paula Silva; Moreira, João Nuno; et al. "Evaluating Blood-Brain Barrier Permeability Changes during Premetastatic Niche Formation for HER2+ Breast Cancer Brain Metastasis". Paper presented in EACR 2023 Congress, 2023.
  5. Canário, Rita; Morgado, Inês; Ribeiro, Ana Sofia; Mendes, Nuno; Teixeira, Manuel R.; BARTOSCH, CARLA; Paredes, Joana. "P-cadherin: a promising prognostic biomarker for homologous repair proficient high grade serous ovarian carcinoma". Paper presented in ESGO 2022 Congress, 2022.
  6. Castro, Maria Miguel ; Esquível, Catarina; Jesus, Tito T.; Ribeiro, Ana Sofia; Sousa, Bárbara; Jerónimo, Carmen; Paredes, Joana. "Effect of cell-cell adhesion disruption on anoikis-resistance and aggregation in Inflammatory Breast Cancer Cells". Paper presented in 5th PhDay, 2022.
  7. Morgado, Inês; Canário, Rita; Ribeiro, Ana Sofia; Paredes, Joana. "Impacto da expressão da P-caderina na aquisição de um fenótipo híbrido epitelial-mesenquimal no carcinoma do ovário". Paper presented in 4th ENJIO, 2022.
  8. Canário, Rita; Morgado, Inês; Mendes, Nuno; Teixeira, Manuel R.; Ribeiro, Ana Sofia; BARTOSCH, CARLA; Paredes, Joana. Corresponding author: Canário, Rita. "P-cadherin overexpression is associated with shorter overall survival in high grade serous ovarian cancer". Paper presented in ASPIC 5th International Congress, 2022.
  9. Castro, Maria Miguel ; Esquível, Catarina; Teles Jesus, Tito; Ribeiro, Ana Sofia; Sousa, Bárbara; Jerónimo, Carmen; Paredes, Joana. Corresponding author: Castro, Maria Miguel. "The role of cell-cell adhesion in the survival of inflammatory breast cancer tumour emboli". Paper presented in 4th PhDAY Break borders build opportunities, 2021.
  10. Esquível, Catarina; Jesus, Tito; Castro, Maria Miguel ; Canário, Rita; Sousa, Bárbara; Ribeiro, Ana Sofia; Paredes, Joana. "P-cadherin as a phenotypic stability factor of the Hybrid Epithelial / Mesenchymal phenotype in Breast Cancer". Paper presented in II ASPIC-ASEICA International Meeting ¿ Current Trends in Precision Medicine in Cancer, 2021.
  11. Carvalho, R.; Conde, Inês; Santos, L.; Leitão, R.; Gomes, C.; Silva, AP; Schmitt, F.; Paredes, Joana; Ribeiro, Ana Sofia. "Best Poster Prize: Deciphering the impact of cancer cell ´s secretome and its derived-peptides on breast cancer brain metastasis". Paper presented in ENJIO LPCC-NRN, 2021.
  12. Ribeiro AS. Corresponding author: Ribeiro AS. "Deciphering the impact of cancer cell´s secretome and its derived-peptides on breast cancer brain metastasis.". Paper presented in MRS 2021 VIRTUAL MEETING, 2021.
  13. Ribeiro AS; Rita Carvalho. Corresponding author: Ribeiro AS. "Deciphering the impact of cancer cell´s secretome and its derived-peptides on breast cancer brain metastasis.". Paper presented in EACR 2021 Congress, Innovative Cancer Science: Better Outcomes through Research. Virtual Congress., 2021.
  14. Conde, Inês; Carvalho, R.; Pinto, MT; Mendes, N.; Ribeiro, Ana Sofia; Paredes, Joana. "Unravelling a Cancer Stem Cell Signature Associated with Breast Cancer Metastatic Organotropism". Paper presented in 27th Porto Cancer Meeting, 2021.
  15. Santos, Liliana; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "The VGF-derived peptide TLQP-21 released by breast cancer cells promotes the loss of brain endothelial cell monolayer integrity". Paper presented in CANCER BIOLOGY: FROM BASIC TO TRANSLATIONAL RESEARCH webinar organized by Liga Portuguesa Contra o Cancro, 2020.
  16. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "VGF-secreted peptide derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties". Paper presented in Tumor Microenvironment (EACR-AACR Basic and Translational Research Conference in partnership with ASPIC), 2020.
  17. Carvalho, R.; Oliveira, M.; Conde, Inês; Paredes, Joana; Ribeiro, Ana Sofia. "Characterization of the secretome profile in brain metastatic breast cancer cells". Paper presented in 8th i3S Annual Meeting, 2019.
  18. Ribeiro, Ana Sofia. "Enrichment of a breast cancer stem cell signature in human brain metastases associates with a worse breast cancer prognosis". Paper presented in 8th i3S Annual Meeting, Póvoa De Varzim, Portugal. November 2019, 2019.
  19. Ribeiro, Ana Sofia. "Characterization of the cancer stem cell phenotype in organotropic breast cancer cells.". Paper presented in 8th i3S Annual Meeting, Póvoa De Varzim, 2019.
  20. Ribeiro, Ana Sofia. "Deciphering the specifically enriched signature associated with breast cancer brain metastasis". Paper presented in 8th i3S Annual Meeting, Póvoa De Varzim, 2019.
  21. Ribeiro, Ana Sofia. "Deciphering the specifically enriched signature associated with breast cancer brain metastasis". Paper presented in 2nd Joint EACR-MRS Conference. Seed and Soil-In vivo Models of metastasis, 2019.
  22. Santos, Liliana; Carvalho, Rita; Leitão, Ricardo Alexandre; Ribeiro, Ana Sofia; Paredes, Joana; Silva, Ana Paula; Gomes, Célia. "Secretome derived from brain metastatic breast cancer cells interferes with blood-brain barrier properties". Paper presented in CIBB Meeting, 2019.
  23. Carvalho R; Oliveira M; Vieira AF; Paredes J; Ribeiro AS. "Deciphering the specifically enriched signature associated with breast cancer brain metastasis.". Paper presented in Secretome without borders, 2018.
  24. Carvalho R; Oliveira M; Vieira AF; Paredes J; Ribeiro AS. "Deciphering the specifically enriched signature associated with breast cancer brain metastasis.". Paper presented in 3rd ASPIC, 2018.
  25. Ribeiro AS; Carvalho R; Oliveira M; Vieira AF; Paredes J. "Unraveling the impact of breast cancer cell’s matrisome in the preparation of the brain metastatic niche.". Paper presented in 1st Joint EACR-MRS Conference, Seed and Soil-In Vivo Models of Metastasis, Berlin, Germany, 2017.
  26. Ribeiro AS; Nobre AR; Carvalho FA; Mestre T; Monteiro J; Fonseca M; Figueiredo J; et al. "Targeting P-cadherin/Src induced collective cell invasion and mechanotransduction signalling: dasatinib as a promising therapy to basal-like breast cancer". Paper presented in Gordon Research Conference - Signaling by Adhesion Receptors, Bates College, Lewiston - Maine, US, 2016.
  27. Ribeiro, Ana. "Impact of the P-cadherin/SFK mechanostransduction signaling in triple-negative breast cancer cell invasive behavior". Paper presented in Enabling Technologies in 3D Cancer Organoids, Torino, Italy, 2016.
  28. Ribeiro, Ana; Nobre AR; Monteiro J; Carvalho F; Vieira AF; Sousa B; Paredes J. "Impact of the P-cadherin/SFK mechanostransduction signaling in triple-negative breast cancer cell invasive behavior.". Paper presented in 3rd Advanced Summer School - Interrogations at the Biointerface, Porto, Portugal, 2015.
  29. Ribeiro, A.S.; Nobre AR; Monteiro J; Carvalho F; Santos NC; Paredes J. "Impact of the P-cadherin/SFK mechanostransduction signaling in triple-negative breast cancer cell invasive behavior.". Paper presented in Porto Cancer Meeting, Porto, Portugal, 2015.
  30. Ribeiro, A.S.; Nobre AR; Monteiro J; Carvalho F; Santos NC; Paredes J. "Impact of the P-cadherin/SFK mechanostransduction signaling in triple-negative breast cancer cell invasive behavior.". Paper presented in 1st ASPIC meeting, Lisbon, Portugal, 2014.
  31. Ribeiro, A.S.; Nobre AR; Carvalho F; Santos NC; Paredes J. "Impact of the P-cadherin/SFK mechanostransduction signaling in triple-negative breast cancer cell invasive behavior.". Paper presented in Goodbye Flat Biology, EACR Conference, Berlin, Germany, 2014.
  32. Ribeiro, A.S.; Nobre AR; Vieira AF; Paredes J. "P-cadherin activates Src-Kinase: a new signaling pathway with implications in breast cancer progression". Paper presented in EMT meeting, Alicante, Spain, November 2013, 2013.
  33. Ribeiro, A.S.; Vieira AF; Nobre AR; Sousa B; Paredes J. "P-cadherin activates Src-Kinase: a new signaling with implications in breast cancer progression". Paper presented in XXII Porto Cancer meeting, Porto, Portugal, April 2013, 2013.
  34. Ribeiro, A.S.; Vieira AF; Nobre AR; Paredes J. "P-cadherin activates Src-kinase: a new signaling with implications in breast cancer progression". Paper presented in EACR, Barcelona, Spain, 2012.
  35. Ribeiro, A.S.; Sousa B; Seruca R; Schmitt F; Paredes J. "Disruption of the cadherin/catenin complex and activation of Rac 1 and Src kinase signaling by the cancer stem cell marker P-cadherin". Paper presented in 7th International meeting of the Portuguese society for stem cells and cell therapies, Porto, Portugal, April 2012, 2012.
  36. Ribeiro, A.S.; Albergaria A; Sousa B; Schmitt F; Paredes J. "P-cadherin overexpression disrupts the cadherin/catenin complex by promoting p120ctn delocalization and by activating Src and Rac1 pathway". Paper presented in 28th InternationaI IABCR/Breaktrough Btreast Cancer Conference, 2012.
  37. Ribeiro, Ana. "P-cadherin promotes cancer cell invasion by interference with E-cadherin suppressor function". Paper presented in 1st Advanced Summer School - Interrogations at the Biointerface, Porto, Portugal,, 2011.
  38. Ribeiro, A.S.; Sousa B; Carreto LC; Schmitt F; Paredes J. "P-cadherin promotes cancer cell invasion by interference with E-cadherirn suppressor function". Paper presented in ICC on Metastasis and Angiogenesis, Barcelona, Spain, 2011.
  39. Ribeiro, Ana. "P-cadherin promotes cancer cell invasion by interference with E-cadherin suppressor function". Paper presented in I3S retreat, Póvoa do Varzim, Portugal, 2011.
  40. Ribeiro, Ana. "P-cadherin promotes cancer cell invasion by interference with E-cadherin suppressor function". Paper presented in SINAL 2011, Coimbra, Portugal, 2011.
  41. Ribeiro, Ana. "o-expression of E- and P-cadherin in breast cancer: suppressing or promoting cancer cell invasion?". Paper presented in 16th Charles Heidelberger Symposium on Cancer Research, Coimbra, Portugal, 2010.
  42. Ribeiro, A.S.. "Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?". Paper presented in 21st European Association for Cancer Research conference, Oslo, Norway, 2010.
  43. Ribeiro, A.S.. "Co-expression of E- and P-cadherin in breast cancer: role as an invasion suppressor or as an invasion promoter?". Paper presented in Porto Cancer Meeting, Porto, Portugal, 2010.
  44. Ribeiro, A.S.. ""Extracellular cleavage of P-cadherin: a mechanism underlying the invasive behaviour of breast cancer cells"". Paper presented in FEBS/EACR Advanced Lecture Course, Spetses Island, Greece, 2009.
  45. Ribeiro, A.S.. "In vitro Functional Assays to characterize the role of P-cadherin in breast cancer cells". Paper presented in European Network of Breast Development and Cancer workshop, Weggis, Switzerland May 2009, 2009.
  46. Ribeiro, A.S.. "P-cadherin induces breast cancer cells motility and stimulates cell invasion through secretion of pro invasive factors". Paper presented in EBS Workshop: Invadopodia, Podossomes and Focal Adhesions in Tissue Invasion, Italy, 2007.
  47. Ribeiro, A.S.; Schmitt F; Paredes J. "P-cadherin promotes cell migration in a breast cancer cell line and induces the activity and expression of MMP-1 and MMP-2 in a collagen-dependent manner”,". Paper presented in EMBO Molecular Medicine Conference: Common Molecular Mechanisms of Mammary Gland Development and Breast Cancer Progression, June 2006, 2006.
Journal article
  1. Rita Carvalho; Liliana Santos; Ines Conde; Ricardo Leitao; Hugo R. S. Ferreira; Celia Gomes; Ana Paula Silva; et al. Corresponding author: Ribeiro, Ana Sofia. "Deciphering the impact of cancer cells secretome and its derived-peptide VGF on breast cancer brain metastasis". (2024): https://www.biorxiv.org/content/biorxiv/early/2024/02/25/2024.02.22.581537.full.pdf.
  2. Almeida, Sara F.F.; Santos, Liliana; Sampaio-Ribeiro, Gabriela; Ferreira, Hugo R.S.; Lima, Nuno; Caetano, Rui; Abreu, Mónica; et al. "Unveiling the role of osteosarcoma-derived secretome in premetastatic lung remodelling". Journal of Experimental & Clinical Cancer Research 42 1 (2023): http://dx.doi.org/10.1186/s13046-023-02886-9.
    10.1186/s13046-023-02886-9
  3. Leonor Côrte-Real; Ana Rita Brás; Adhan Pilon; Nuno Mendes; Ana Sofia Ribeiro; Tiago D. Martins; José Paulo S. Farinha; et al. "Biotinylated Polymer-Ruthenium Conjugates: In Vitro and In Vivo Studies in a Triple-Negative Breast Cancer Model". Pharmaceutics 14 7 (2022): 1388-1388. https://doi.org/10.3390/pharmaceutics14071388.
    10.3390/pharmaceutics14071388
  4. Inês Conde; Ana Sofia Ribeiro; Joana Paredes. "Breast Cancer Stem Cell Membrane Biomarkers: Therapy Targeting and Clinical Implications". Cells 11 6 (2022): 934-934. https://doi.org/10.3390/cells11060934.
    10.3390/cells11060934
  5. Noronha, Carolina; Ribeiro, Ana Sofia; Taipa, Ricardo; Leitão, Dina; Schmitt, Fernando; Reis, Joaquim; Faria, Cláudia; Paredes, Joana. "PD-L1 tumor expression is associated with poor prognosis and systemic immunosuppression in glioblastoma". Journal of Neuro-Oncology 156 3 (2022): 453-464. http://dx.doi.org/10.1007/s11060-021-03907-3.
    10.1007/s11060-021-03907-3
  6. Martins, Eduarda P.; Gonçalves, Céline S.; Pojo, Marta; Carvalho, Rita; Ribeiro, Ana S.; Miranda-Gonçalves, Vera; Taipa, Ricardo; et al. "CDH3 is a novel oncogenic biomarker with prognostic value in glioblastoma". Molecular Oncology (2021): http://dx.doi.org/10.1002/1878-0261.13162.
    Published • 10.1002/1878-0261.13162
  7. Carolina Noronha; Ana Sofia Ribeiro; Ricardo Taipa; Diogo S. Castro; Joaquim Reis; Cláudia Faria; Joana Paredes. "Cadherin Expression and EMT: A Focus on Gliomas". Biomedicines (2021): https://doi.org/10.3390/biomedicines9101328.
    10.3390/biomedicines9101328
  8. Marta Teixeira Pinto; Ana Sofia Ribeiro; Inês Conde; Rita Carvalho; Joana Paredes. "The Chick Chorioallantoic Membrane Model: A New In Vivo Tool to Evaluate Breast Cancer Stem Cell Activity". International Journal of Molecular Sciences 22 1 (2020): 334-334. https://doi.org/10.3390/ijms22010334.
    10.3390/ijms22010334
  9. Dionísio, Maria Rita; Vieira, André F.; Carvalho, Rita; Conde, Inês; Oliveira, Mónica; Gomes, Madalena; Pinto, Marta T.; et al. "BR-BCSC Signature: The Cancer Stem Cell Profile Enriched in Brain Metastases that Predicts a Worse Prognosis in Lymph Node-Positive Breast Cancer". Cells 9 11 (2020): 2442. http://dx.doi.org/10.3390/cells9112442.
    10.3390/cells9112442
  10. Blair, Vanessa R; McLeod, Maybelle; Carneiro, Fátima; Coit, Daniel G; D'Addario, Johanna L; van Dieren, Jolanda M; Harris, Kirsty L; et al. "Hereditary diffuse gastric cancer: updated clinical practice guidelines". The Lancet Oncology 21 8 (2020): e386-e397. http://dx.doi.org/10.1016/s1470-2045(20)30219-9.
    10.1016/s1470-2045(20)30219-9
  11. Carvalho, R.; Paredes, J.; Ribeiro, A.S.. "Impact of breast cancer cells´ secretome on the brain metastatic niche remodeling". Seminars in Cancer Biology (2019): http://dx.doi.org/10.1016/j.semcancer.2019.10.011.
    Published • 10.1016/j.semcancer.2019.10.011
  12. Pinto, Catarina; Silva, Gabriela; Ribeiro, Ana S.; Oliveira, Mónica; Garrido, Manuel; Bandeira, Vanessa S.; Nascimento, André; et al. "Evaluation of AAV-mediated delivery of shRNA to target basal-like breast cancer genetic vulnerabilities". Journal of Biotechnology 300 (2019): 70-77. http://dx.doi.org/10.1016/j.jbiotec.2019.05.016.
    10.1016/j.jbiotec.2019.05.016
  13. Figueiredo, Joana; Melo, Soraia; Carneiro, Patrícia; Moreira, Ana Margarida; Fernandes, Maria Sofia; Ribeiro, Ana Sofia; Guilford, Parry; Paredes, Joana; Seruca, Raquel. "Clinical spectrum and pleiotropic nature of CDH1 germline mutations". Journal of Medical Genetics (2019): jmedgenet-2018. http://dx.doi.org/10.1136/jmedgenet-2018-105807.
    10.1136/jmedgenet-2018-105807
  14. Ana Sofia Ribeiro; Ana Rita Nobre; Nuno Mendes; João Almeida; André Filipe Vieira; Bárbara Sousa; Filomena A. Carvalho; et al. "SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells". Cell Communication and Signaling 16 1 (2018): https://doi.org/10.1186/s12964-018-0286-2.
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  15. Hoop, Marcus; Ribeiro, Ana Sofia; Rösch, Daniel; Weinand, Philipp; Mendes, Nuno; Mushtaq, Fajer; Chen, Xiang-Zhong; et al. "Mobile Magnetic Nanocatalysts for Bioorthogonal Targeted Cancer Therapy". Advanced Functional Materials 28 25 (2018): 1705920. http://dx.doi.org/10.1002/adfm.201705920.
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  16. Mestre, Tânia; Figueiredo, Joana; Ribeiro, Ana Sofia; Paredes, Joana; Seruca, Raquel; Sanches, João Miguel. "Erratum: Corrigendum: Quantification of topological features in cell meshes to explore E-cadherin dysfunction". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep30222.
    10.1038/srep30222
  17. Ribeiro, A.S.; Carvalho, F.A.; Figueiredo, J.; Carvalho, R.; Mestre, T.; Monteiro, J.; Guedes, A.F.; et al. "Atomic force microscopy and graph analysis to study the P-cadherin/SFK mechanotransduction signalling in breast cancer cells". Nanoscale 8 46 (2016): 19390-19401. http://www.scopus.com/inward/record.url?eid=2-s2.0-84998881935&partnerID=MN8TOARS.
    10.1039/c6nr04465d
  18. Mestre, T.; Figueiredo, J.; Ribeiro, A.S.; Paredes, J.; Seruca, R.; Sanches, J.M.. "Quantification of topological features in cell meshes to explore E-cadherin dysfunction". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84971367761&partnerID=MN8TOARS.
    10.1038/srep25101
  19. Ribeiro, A.S.; Paredes, J.. "P-cadherin linking breast cancer stem cells and invasion: A promising marker to identify an "intermediate/metastable" EMT state". Frontiers in Oncology 4 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-85018189090&partnerID=MN8TOARS.
    10.3389/fonc.2014.00371
  20. Vieira AF; Ribeiro AS; Dionísio MR; Sousa B; Nobre AR; Albergaria A; Santiago-Gómez A; et al. "P-cadherin signals through the laminin receptor a6ß4 integrin to induce stem cell and invasive properties in basal-like breast cancer cells.". (2014): http://europepmc.org/abstract/med/24553076.
  21. Vieira, A.F.; Ribeiro, A.S.; Dionísio, M.R.; Sousa, B.; Nobre, A.R.; Albergaria, A.; Santiago-Gómez, A.; et al. "P-cadherin signals through the laminin receptor a6ß4 integrin to induce stem cell and invasive properties to basal-like breast cancer cells". Oncotarget 5 3 (2014): 679-692. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896821980&partnerID=MN8TOARS.
  22. Bernardes, N.; Ribeiro, A.S.; Abreu, S.; Vieira, A.F.; Carreto, L.; Santos, M.; Seruca, R.; Paredes, J.; Fialho, A.M.. "High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin". International Journal of Biochemistry and Cell Biology 50 1 (2014): 1-9. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896720191&partnerID=MN8TOARS.
    10.1016/j.biocel.2014.01.023
  23. Sousa, B.; Ribeiro, A.S.; Nobre, A.R.; Lopes, N.; Martins, D.; Pinheiro, C.; Vieira, A.F.; et al. "The basal epithelial marker P-cadherin associates with breast cancer cell populations harboring a glycolytic and acid-resistant phenotype". BMC Cancer 14 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84908094892&partnerID=MN8TOARS.
    10.1186/1471-2407-14-734
  24. van der Werf, C.S.; Hsiao, N.-H.; Conroy, S.; Paredes, J.; Ribeiro, A.S.; Sribudiani, Y.; Seruca, R.; et al. "CLMP Is Essential for Intestinal Development, but Does Not Play a Key Role in Cellular Processes Involved in Intestinal Epithelial Development". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84874534682&partnerID=MN8TOARS.
    10.1371/journal.pone.0054649
  25. Ribeiro, A.S.; Sousa, B.; Carreto, L.; Mendes, N.; Nobre, A.R.; Ricardo, S.; Albergaria, A.; et al. "P-cadherin functional role is dependent on E-cadherin cellular context: A proof of concept using the breast cancer model". Journal of Pathology 229 5 (2013): 705-718. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875054847&partnerID=MN8TOARS.
    10.1002/path.4143
  26. Bernardes, N.; Ribeiro, A.S.; Abreu, S.; Mota, B.; Matos, R.G.; Arraiano, C.M.; Seruca, R.; Paredes, J.; Fialho, A.M.. "The Bacterial Protein Azurin Impairs Invasion and FAK/Src Signaling in P-Cadherin-Overexpressing Breast Cancer Cell Models". PLoS ONE 8 7 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880423678&partnerID=MN8TOARS.
    10.1371/journal.pone.0069023
  27. Albergaria, A.; Resende, C.; Nobre, A.R.; Ribeiro, A.S.; Sousa, B.; Machado, J.C.; Seruca, R.; Paredes, J.; Schmitt, F.. "CCAAT/Enhancer Binding Protein ß (C/EBPß) Isoforms as Transcriptional Regulators of the Pro-Invasive CDH3/P-Cadherin Gene in Human Breast Cancer Cells". PLoS ONE 8 2 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84873547668&partnerID=MN8TOARS.
    10.1371/journal.pone.0055749
  28. Van Der Werf, C.S.; Wabbersen, T.D.; Hsiao, N.; Paredes, J.; Etchevers, H.C.; Kroisel, P.M.; Tibboel, D.; et al. "CLMP is required for intestinal development, and loss-of-function mutations cause congenital short-bowel syndrome". Gastroenterology 142 3 (2012): 453-462. http://www.scopus.com/inward/record.url?eid=2-s2.0-84857636412&partnerID=MN8TOARS.
    10.1053/j.gastro.2011.11.038
  29. Paredes, J.; Figueiredo, J.; Albergaria, A.; Oliveira, P.; Carvalho, J.; Ribeiro, A.S.; Caldeira, J.; et al. "Epithelial E- and P-cadherins: Role and clinical significance in cancer". Biochimica et Biophysica Acta - Reviews on Cancer 1826 2 (2012): 297-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-84861800037&partnerID=MN8TOARS.
    10.1016/j.bbcan.2012.05.002
  30. Albergaria, A.; Ribeiro, A.-S.; Vieira, A.-F.; Sousa, B.; Nobre, A.-R.; Seruca, R.; Schmitt, F.; Paredes, J.. "P-cadherin role in normal breast development and cancer". International Journal of Developmental Biology 55 7-9 (2011): 811-822. http://www.scopus.com/inward/record.url?eid=2-s2.0-82555201366&partnerID=MN8TOARS.
    10.1387/ijdb.113382aa
  31. Ribeiro, A.S.; Albergaria, A.; Sousa, B.; Correia, A.L.; Bracke, M.; Seruca, R.; Schmitt, F.C.; Paredes, J.. "Extracellular cleavage and shedding of P-cadherin: A mechanism underlying the invasive behaviour of breast cancer cells". Oncogene 29 3 (2010): 392-402. http://www.scopus.com/inward/record.url?eid=2-s2.0-75149183984&partnerID=MN8TOARS.
    10.1038/onc.2009.338
  32. Albergaria, A.; Ribeiro, A.S.; Pinho, S.; Milanezi, F.; Carneiro, V.; Sousa, B.; Sousa, S.; et al. "ICI 182,780 induces P-cadherin overexpression in breast cancer cells through chromatin remodelling at the promoter level: A role for C/EBPß in CDH3 gene activation". Human Molecular Genetics 19 13 (2010): 2554-2566. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954172745&partnerID=MN8TOARS.
    10.1093/hmg/ddq134
  33. Velho, S.; Oliveira, C.; Paredes, J.; Sousa, S.; Leite, M.; Matos, P.; Milanezi, F.; et al. "Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours". Human Molecular Genetics 19 4 (2009): 697-706. http://www.scopus.com/inward/record.url?eid=2-s2.0-77950353937&partnerID=MN8TOARS.
    10.1093/hmg/ddp536
  34. Preto, A.; Figueiredo, J.; Velho, S.; Ribeiro, A.S.; Soares, P.; Oliveira, C.; Seruca, R.. "BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAFV600E but not KRAS mutations". Journal of Pathology 214 3 (2008): 320-327. http://www.scopus.com/inward/record.url?eid=2-s2.0-38949208776&partnerID=MN8TOARS.
    10.1002/path.2295
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    10.1136/jcp.2007.052704
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Preprint
  1. Irina Fonseca; Cíntia Horta; Ana Sofia Ribeiro; Barbara Sousa; Gaëlle Marteil; Mónica Bettencourt-Dias; Joana Paredes. "Polo-like kinase 4 (Plk4) potentiatesanoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype". 2022. https://doi.org/10.1101/2022.12.16.520613.
    10.1101/2022.12.16.520613
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2021/10 UNRAVELING THE CROSSTALK BETWEEN BRAIN METASTATIC STEM-LIKE CANCER CELLS AND THE PRE-METASTIC NICHE XII COngresso Nacional Neuro-Oncologia
(Virtual meeting)
2021 Deciphering the impact of cancer cell´s secretome and its derived-peptides on breast cancer brain metastasis Virtual 27th Porto cancer meeting Stemness & Metastasis: Advances in Research and Clinical Translation
IPATIMUP (Porto)
2021 Deciphering the impact of cancer cell´s secretome and its derived-peptides on breast cancer brain metastasis II ASPIC-ASEICA International Meeting - Current Trends in Precision Medicine in Cancer
ASPIC/ASEICA (virtual, Spain)
2021 Deciphering the impact of cancer cell´s secretome and its derived-peptides on breast cancer brain metastasis 9th Annual Brain Mets Congress Paris
(Paris, France)
2019/12/11 Deciphering the secretome signature enriched in breast cancer brain metastasis International Conference "Cancer Metastasis"
(Seefeld-in-Tirol, Switzerland)
2018/11/12 Deciphering the specifically enriched signature associated with breast cancer brain metastasis 7th i3S Annual Meeting
i3s (Póvoa do varzim, Portugal)
2018/09/24 Deciphering the specifically enriched signature associated with breast cancer brain metastasis 8th Annual Brain Mets Congress Marseille
(Marselha)
2018/03 Breast cancer BRAIN METastaseS: uncovering the biomechanical crosstalk between cancer cells and the brain microenvironment Gabba Program
(Porto, Portugal)
2017/10 Impact of the P-CADHERIN/SFK mechanotrasnduction signaling in triple-negative breast cancer. Ciência Falada, ICVS, Braga, Portugal, October 2017 Ciência Falada, ICVS
(Braga, Portugal)
2017/03/10 Impact of the P-cadherin/SFK mechanostransduction signaling in triple-negative breast cancer cell invasive behavior Annual Meeting of the French Society for ECM biology
(Marselha, France)
2017/03 Mechanisms of cancer cell invasion and metastization: The role of cell adhesion molecules. Gabba Program, i3S, Porto, Portugal, March 2017 Gabba Program, i3S
(Porto, Portugal)
2016/04/09 SRC inhibition prevents P-cadherin mediated signaling and function in basal-like breast cancer cells 2nd ASPIC meeting
(Porto, Portugal)
2016/03/05 Combining 2D and 3D in vitro models to evaluate the effect of P-cadherin/SFK mechanostransduction signaling in breast cancer cell invasive behaviour Enabling Technologies in 3D Cancer Organoids
(Torino, Italy)
2016/03 Mechanisms of cancer cell invasion and metastization: The role of P-cadherin. Gabba Program, i3S, Porto, Portugal, March 2016 Gabba Program, i3S
(Porto, Portugal)
2015/10 Mechanisms of cancer cell invasion and metastization. Fundamentals in Genetics, Development and Neoplasia. ICVS, Braga, Portugal, October 2015 Fundamentals in Genetics, Development and Neoplasia.
ICVS (Braga, Portugal)
2015/01 Mechanisms of cancer cell invasion and metastization: The role of cadherins. , ICVS, Braga, Portugal, January 2015 Aula incluida no módulo de Oncobiologia do 3ºano de Medicina
ICVS (Braga, Portugal)
2014/10/04 P-cadherin represses cell-cell adhesion mediated by E-cadherin in breast cancer cells: an AFM analysis 3rd Bioimaging Symposium
(Porto, Portugal)
2014/05 P-cadherin in Breast Cancer: a prognostic factor, an inducer of cancer cell invasion and metastasis and a therapeutic target Workshop on Cancer Research
IPATIMUP (Porto, Portugal)
2014/04 P-cadherin: Does it have a role in the metastable phenotype? Gabba Program
IPATIMUP (Porto, Portugal)
2014/02 Cadherins, Cancer Stem Cells and Metastasis. Speed Dating and Cancer: basic biology and beyond
Universidade de Coimbra (Coimbra, Portugal)
2013/04 O papel das caderinas epiteliais na progressão tumoral. V Encontro ENEBIOQ
(Coimbra, Portugal)
2013 Mecanismos moleculares envolvidos na invasão cancerígena focados no papel da E-caderina e P-caderina. , Congresso Oncologia dos Alunos de 5.º Ano de Ciências Farmacêuticas
Universidade da Beira Interior (Covilhã, Portugal)
2012/05/04 P-cadherin activates Src-kinase: A new signaling pathway with implications in breast cancer progression I3S Retreat
(Póvoa de varzim, Portugal)
2012/01 Molecular biology tecnhiques applyed to cancer research. , Oncobiology Class from the Master in Biomedical Sciences
Universidade da Covilhã (Covilhã, Portugal)
2011 Invasion and metastization during cancer progression. Oncobiology Class from the Master in Clinical Analysis
CESPU (Gandra, Portugal)
2008/04/06 P-cadherin induces breast cancer cells motility and stimulates cell invasion through secretion of pro invasive factors XXVIII Encontro da SOBRAC
(Porto, Portugal)
2008/02/01 P-cadherin: role in breast cancer migration and invasion 1st meeting for young investigators from Oporto University
(Porto, Portugal)
2007/11/01 P-cadherin induces breast cancer cells motility and stimulates cell invasion through secretion of pro invasive factors 11st annual meeting from the Portuguese Society from Human Genetics
(Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018 - Current Cadherin Expression and EMT in Gliomas
Co-supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017/10/01 - Current Deciphering the specifically enriched signature associated with breast cancer brain metastasis.
Co-supervisor
 Ciências Biomédicas (PhD)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 - Current Exploring the role of p-cadherin and epithelial-mesenchymal plasticity in ovarian cancer
Co-supervisor
2019/09/01 - 2021/11 Defining the cancer stem cell profile of organotropic metastatic breast cancer cells
Supervisor
 Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/01/01 - 2019/08 Characterization of the Cancer Stem Cell phenotype in breast cancer brain metastasis
Supervisor
 Bioquímica (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2015/03/01 - 2016/12/20 Combining shRNA and AAV therapy approaches to target human basal-like breast cancer.
Co-supervisor
 Biomedicina (Master)
Universidade de Aveiro, Portugal
2014/06/01 - 2015/12/31 Dasatinib as an option to treat P-cadherin overexpressing poor prognosis breast cancer
Co-supervisor
 Oncologia Molecular (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/06/01 - 2014/12/01 Impact of P-cadherin expression in the modulation of E-cadherin adhesive function in cancer cells
Co-supervisor
 Oncologia Molecular (Master)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020 - Current Organoids With]Out[ Borders - Online Symposium (2020/11)
Symposium (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2015/06/01 - Current Interrogations at the biointerface – The nano/medicine interface Involved in the organization of Lab-Session: “Nanodrugs delivery and anti-tumoral effects on cancer cells: a time-lapse microscopy approach to monitor biological events” (2015/06/01)
Symposium (Co-organisor)
 Instituto Nacional de Engenharia Biomédica, Portugal
2014/10/01 - Current BIOIMAGING Symposium 2014 - International Symposium in Applied Bioimaging from pixel to Life Involved in the organization of the symposium and participated in the pratical lectures (2014/10/01)
Conference (Co-organisor)
 Instituto Nacional de Engenharia Biomédica, Portugal
2018/05 - 2018/05 3º Congresso Internacional da ASPIC (2018 - 2018)
Congress (Co-organisor)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021 - Current Science Ambassador at i3S Educational Program
Other
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/05 - 2021/05 Chair at the Session: Invasion, Dissemination & Metastasis, in XXVII Porto Cancer Meeting
Congress
 XXVII Porto Cancer Meeting
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2018/02/15 - 2018/03/08 Advanced course: “Hands-on the rodent brain: from intracellular trafficking to brain connectome” The focus was on practicing/performing different techniques/approaches, such as: 1) intracranial surgeries in the mouse and in the rat 2) stereotaxic injection/dialysis of drugs, viruses, and cells 3) optogenetic control of specific cell populations 4) electrode implantation: spike and local field potential recording 5) brain tissue fixation, sectioning and immunofluorescence analysis 6) preparation of acute brain slices 7) patch clamp recordin
Other
 Advanced course: “Hands-on the rodent brain: from intracellular trafficking to brain connectome”
Laboratório Associado ICVS 3B's, Portugal
2015/04/01 - 2015/04/15 Experimental Design and Statistical Analysis of Biomedical Experiments • Basic training in experimental design techniques • Instruction in statistical methods to ensure data is analysed correctly • Advice on legal and ethical considerations when using experimental animals • Opportunity to evaluate procedures before putting them into practice • Chance to meet with other researchers to discuss ideas and exchange expertise • Practical skills that can be used daily in laboratories
Other
 Experimental Design and Statistical Analysis of Biomedical Experiments
Universidade de Coimbra, Portugal
2012/04/01 - 2012/04/15 Laboratory Animal Science Course – Category C – Felasa accredited course Appropriate training in animal biology, experimental techniques and other relevant topics is a prerequisite for responsible conduct with animals in research.
Other
 Laboratory Animal Science Course – Category C – Felasa accredited course
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2022/10/28 Promoter methylation of DNA repair genes as biomarker of response to platinum-based chemotherapy: a pan-cancer investigation
(Thesis) Main arguer
 Saule Gumauskaite (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2022/03 Unravelling the role of the spinocerebellar ataxia type 3-associated protein ATXN3 in glioblastoma
(Thesis) Main arguer
 Ana Margarida Machado Sousa (Master)
Escola de Medicina da Universidade do Minho, Portugal

Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2021/12 Unraveling the interplay between fibroblasts and osteosarcoma cells during lung metastasis formation
(Thesis) Main arguer
 Gabriela Sampaio Ribeiro (Master)
Instituto de Investigação Clínica e Biomédica de Coimbra (iCBR), Portugal

Faculdade de Medicina da Universidade de Coimbra (FMUC), Portugal
2021 m6ACODE: Deciphering the hidden message in m6A methylation in Gastric Cancer
(Thesis) Main arguer
 Diana Cristina Silva Ferreira (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/11/20 Differential expression of cadherins in bladder cancer: role in epithelial- mesenchymal transition
(Thesis) Main arguer
 Cláudia Martins de Lima (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/09/04 Local Anesthetics as a new therapeutic approach in oral squamous cell carcinoma – an in vitro study. Mestrado em Patologia Experimental. Universidade de Coimbra, September 2016
(Thesis) Main arguer
 Ana Isabel de Almeida Lopes Ribeiro (Master)
Hospitais da Universidade de Coimbra, Portugal
2015/11/05 Hypoxia in a 3D in vitro Spheroid Model: the role on Tumor Progression and Response to Chemotherapy. Master of Science Degree in Biological Engineering, Instituto Superior Técnico, Universidade de Lisboa, November 2015
(Thesis) Main arguer
 Inês Santos de Almeida Godet (Master)
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2015/07/02 . Synergy between antiangiogenic and immuno- therapies in breast cancer. Mestrado em Biomedicina, Universidade de Aveiro, July 2015
(Thesis) Main arguer
 Daniela Pais Ferreira (Master)
Universidade de Aveiro, Portugal

Association member

Society Organization name Role
2021/09 - Current GRASP - GUIDING RESEARCHERS & ADVOCATES TO SCIENTIFIC PARTNERSHIPS Research Member
2016/06 - Current Metastasis Research Society
2016 - Current ASPIC Sócio
2005/09 - Current EACR

Committee member

Activity description
Role 		Institution / Organization
2022/02 - Current • Member of the ORBEA (Animal Welfare and Ethics Body), responsible for monitoring i3S research projects requiring the use of vertebrate animals.
Member
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/02 - Current S3E START acceleration PROGRAM, supporting Deep Tech in Southern Europe (Outros)
2023/04 - 2023/05 BIP Acceleration Program Tecnhology acceleration program (Outros) Universidade do Porto, Portugal
2023/04 - 2023/04 Mechanisms of cancer invasion and metastization (Pós-Graduação) Universidade do Minho Centro de Biologia Molecular e Ambiental, Portugal
2020/11 - 2020/11 Metastasis and organotropism: Unraveling the crosstalk between cancer cells and the metastic niche. Licenciatura (Licenciatura) Universidade do Porto Faculdade de Medicina, Portugal
2019/10 - 2019/10 Metastasis and organotropism: Unraveling the crosstalk between cancer cells and the metastic niche. Medicina (Bacharelato) Universidade do Porto Faculdade de Medicina, Portugal
2019/06 - 2019/06 Técnicas fundamentais e modelos biológicos para estudo do cancro no laboratório 1º Curso de Investigação (Especialização pós-licenciatura) Sociedade Portuguesa de Oncologia, Portugal
2019/03 - 2019/03 Deciphering the specifically enriched signature associated with breast cancer brain metastasis. Medicina (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2018/03 - 2018/03 Deciphering the specifically enriched signature associated with breast cancer brain metastasis GABBA (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2011 - 2018 Ciênvia Viva nas Escolas: Scientific dissemination activities under the theme: The Universe of cells and the microscope (Ensino básico 1º ciclo) Câmara Municipal do Porto, Portugal
2017/03 - 2017/03 Mechanisms of cancer cell invasion and metastization: The role of cell adhesion molecules GABBA (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2016/03 - 2016/03 Mechanisms of cancer cell invasion and metastization: The role of cell adhesion molecules GABBA (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2015/10 - 2015/10 Mechanisms of cancer cell invasion and metastization Mestrado em Ciências da Sáude (Mestrado) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2015/07 - 2015/07 Ciência Viva No Laboratório (Ensino secundário) Ciência Viva, Portugal
2015/01 - 2015/01 Mechanisms of cancer cell invasion and metastization: The role of cadherins. Medicina (Licenciatura) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2014/07 - 2014/07 Ciência Viva No Laboratório (Ensino secundário) Ciência Viva, Portugal
2014/04 - 2014/04 P-cadherin: Does it have a role in the metastable phenotype? GABBA (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2013/08 - 2013/08 Ciência Viva No Laboratório (Ensino secundário) Ciência Viva, Portugal
2012/08 - 2012/08 Ciência Viva No Laboratório Ciência Viva, Portugal
2011 - 2011 Ciência Viva No Laboratório (Ensino secundário) Ciência Viva, Portugal
2010/07 - 2010/07 Ciência Viva No Laboratório (Ensino secundário) Ciência Viva, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2018/04 - 2019/04 Speed-Talk chair and evaluator for the best presetation at XXV Porto Cancer Meeting
Other
 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2017/05 - 2017/05 Speed-Talk chair and evaluator for the best presetation at XXIV Porto Cancer Meeting
Other
 Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2012/10 - 2012/12 Abstract evaluation at BIOIMAGING 2012
Evaluator
 Instituto Nacional de Engenharia Biomédica, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2021 Pessoa Universidade do Porto Noticias UP

Interview (tv / radio show)

Program Topic
2021/11 - Current Bom dia Portugal - RTP1 Cancer predictive biomarkers
2021/11 - Current Mentes que Brilham - Porto Canal Cancer predictive biomarkers
Distinctions

Award

2023 Hologic Prize for Womens Health
2021 Liga Innovation Prize
Liga Portuguesa Contra o Cancro Núcleo Regional do Centro, Portugal
2016 BEST ORAL PRESENTATION AWARD
Associação Portuguesa de investigação em Cancro, Portugal
2014 BEST POSTER AWARD
Associação Portuguesa de investigação em Cancro, Portugal

Other distinction

2021 GRASP Choice Award
2013 BEST POSTER AWARD
TEMTIA, Australia