???global.info.a_carregar???
Patrícia C. Pires has a Doctoral and Master's degree in Pharmaceutical Sciences from University of Beira Interior, and has been doing research in that field since 2014, with emphasis in pharmaceutical development, pharmaceutical technology, galenic pharmacy, nanotechnology, analytical chemistry, pharmacokinetics and organic chemistry.
Identification

Personal identification

Full name
Patrícia Sofia Cabral Pires

Citation names

  • Pires, Patrícia C.
  • Pires, P. C.
  • Patrícia C. Pires
  • P. C. Pires

Author identifiers

Ciência ID
DF1D-73CF-6BA4
ORCID iD
0000-0003-0036-4894

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Exact Sciences - Chemical Sciences - Analytical Chemistry

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2016/10 - 2021/03
Concluded
 Doctoral Degree in Pharmaceutical Sciences (Doutoramento)
Universidade da Beira Interior, Portugal
"The promise of prodrugs and nanosystems in nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin" (THESIS/DISSERTATION)
 Approved
2011/09 - 2016/06
Concluded
 Integrated Master's Degree in Pharmaceutical Sciences (Mestrado integrado)
Universidade da Beira Interior, Portugal
"Síntese de derivados da estrona funcionalizados nos anéis C e D como potenciais agentes anticancerígenos" (THESIS/DISSERTATION)
Affiliation

Science

Category
Host institution 		Employer
2021/04 - Current Visiting Researcher (Research) Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal
2014/06 - 2021/03 Researcher (Research) Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal
Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2021/10/01 - Current Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/09 - 2021/03 Tutor (University Teacher) Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
Projects

Grant

Designation Funders
2018/09 - 2020/02 ICON: Interdisciplinary Challenges On Neurodegeneration
CENTRO-01-0145-FEDER-000013
PhD Student Fellow
Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal
 Universidade da Beira Interior
Concluded

Other

Designation Funders
2020/03 - Current CovidOUT - Spray para reduzir a transmissão nasal de coronavírus (reference 69358, PT2020, CENTRO2020, FEDER)
69358
Researcher
Universidade da Beira Centro de Investigação em Ciências da Saúde, Portugal

Health Products Research and Development Lda, Portugal
Outputs

Publications

Book chapter
  1. Pires, Patrícia C.; Melo, Dora; Santos, Adriana O.. "Intranasal delivery of antiseizure drugs". In Drug Delivery Devices and Therapeutic Systems, edited by Eric Chappel, 623-646. Elsevier, 2021.
    Published • 10.1016/b978-0-12-819838-4.00022-5
Conference paper
  1. Patrícia C. Pires; Mafalda Rodrigues Luis Correia; Francisco Veiga; Ana Cláudia Paiva-Santos. "Anti-Inflammatory Drug Repurposing for Intranasal Delivery: Ketoprofen Nanoemulgel Development for the Treatment of Glioma". 2023.
    10.3390/asec2023-15345
  2. Margarida Alberto; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "Intranasal Nanoparticles for the Treatment of Depression and Anxiety Disorders". 2022.
    10.3390/asec2022-13853
  3. Maria Ferreira; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "The Importance of Nanosystems in Antipsychotic Drugs Brain Targeting". 2022.
    10.3390/asec2022-13765
  4. Jéssica Lopes Antunes; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "Brain Targeting of Antidepressant and Anxiolytic Drugs". 2022.
    10.3390/asec2022-13766
  5. Joana Amado; Patrícia C. Pires; Francisco Veiga; Ana Cláudia Paiva-Santos. "Miconazole Nanoemulsions to Treat Melanoma: A Study of Formulation Development, Droplet Size and Solubility". 2022.
    10.3390/ecmc2022-13416
  6. P. Pires; A.C. Santos; F. Veiga. "Nanometric emulsions for the treatment of depressive and anxiety disorders". 2022.
    10.1016/j.nsa.2022.100337
Conference poster
  1. Patrícia C. Pires; Francisca S. Nina; SANTOS, ADRIANA O.. "Otimização de nanoemulsões óleo-em-água com caraterísticas ideais de composição e tamanho de gotícula". Paper presented in VI Congresso Científico Anual UBIPharma, Online, 2020, 2020.
  2. Patrícia C. Pires; Márcio Rodrigues; Gilberto Alves; SANTOS, ADRIANA O.. "Brain delivery of poorly soluble drugs: a proof-of-concept of phosphate esters as a way of increasing solubility and bioavailability". Paper presented in Controlled Release Society Virtual Annual Meeting, 2020, 2020.
  3. Patrícia C. Pires; Liliana T. Santos; Márcio Rodrigues; Gilberto Alves; SANTOS, ADRIANA O.. "Nose-to-brain delivery of poorly soluble drugs: the case of phenytoin and fosphenytoin - formulation development, in vitro characterization and in vivo pharmacokinetics". Paper presented in FENS 2020 Virtual Forum, 2020, 2020.
  4. Patrícia C. Pires; Ana C. Fazendeiro; Márcio Rodrigues; Gilberto Alves; SANTOS, ADRIANA O.. "Nose-to-brain delivery of microemulsions containing phenytoin and fosphenytoin: formulation development and pharmacokinetics". Paper presented in XV Annual CICS-UBI Symposium, Virtual Meeting, 2020, 2020.
  5. Patrícia C. Pires; Dora Melo; Adriana O. Santos. "A review of the clinical application of intranasal benzodiazepines in the treatment of epilepsy". Paper presented in XIV Annual CICS-UBI Symposium, Covilhã, Portugal, 2019.
  6. Patrícia C. Pires; Márcio Rodrigues; Gilberto Alves; Adriana O. Santos. "Simultaneous quantification of phenytoin and fosphenytoin in mouse blood and brain using high-performance liquid chromatography: a tool for in vivo studies". Paper presented in 6th European Chemical Biology Symposium, Madrid, Spain, 2019.
  7. Patrícia C. Pires; Liliana T. Santos; Márcio Rodrigues; Gilberto Alves; Adriana O. Santos. "Novel fosphenytoin formulations for intranasal administration - development, characterization and in vitro release studies". Paper presented in 3rd European Conference on Pharmaceutics, Bologne, Italy, 2019.
  8. Patrícia C. Pires; Liliana T. Santos; SANTOS, ADRIANA O.. "Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis". Paper presented in X Beira Interior Medical Meeting, Covilhã, 2019, 2019.
  9. Patrícia C. Pires; Adriana O. Santos. "Brain drug delivery by intranasal nanosystems: a systematic review of pre-clinical studies". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, Coimbra, Portugal, 2018.
  10. Patrícia C. Pires; Joana Ferreira; Gilberto Alves; SANTOS, ADRIANA O.. "The contribution of carbomer in pluronic-based thermoreversible gels of carbamazepine". Paper presented in 13th International Chemical and Biological Engineering Conference, Aveiro, 2018, 2018.
  11. Patrícia C. Pires; Catarina Canário; Mariana Matias; Vanessa de Brito; Adriana O. Santos; Amílcar Falcão; Samuel Silvestre; Gilberto Alves. "Steroidal estrone oximes: cytotoxic effects on hormone-dependent cancer cell lines". Paper presented in XI Annual CICS-UBI Symposium, Covilhã, Portugal, 2016.
Journal article
  1. Kamil Sghier; Maja Mur; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Novel Therapeutic Hybrid Systems Using Hydrogels and Nanotechnology: A Focus on Nanoemulgels for the Treatment of Skin Diseases". Gels (2024): https://www.mdpi.com/2310-2861/10/1/45.
    10.3390/gels10010045
  2. Joana Galvão Duarte; Dr Ankur Sharma; Esmaeel Sharifi; Fouad Damiri; Mohammed Berrada; Sachin Kumar Singh; Kamal Dua; et al. "Topical delivery of nanoemulsions for skin cancer treatment". Applied Materials Today (2023): http://dx.doi.org/10.1016/j.apmt.2023.102001.
    10.1016/j.apmt.2023.102001
  3. Eliana Veiga; Laura Ferreira; Mafalda Rodrigues Luis Correia; Patrícia C. Pires; Huma Hameed; Andre RTS Araujo; Letícia Caramori Cefali; et al. "Anti-aging peptides for advanced skincare: Focus on nanodelivery systems". Journal of Drug Delivery Science and Technology 89 (2023): 105087-105087. http://dx.doi.org/10.1016/j.jddst.2023.105087.
    10.1016/j.jddst.2023.105087
  4. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Liposome-Derived Nanosystems for the Treatment of Behavioral and Neurodegenerative Diseases: The Promise of Niosomes, Transfersomes, and Ethosomes for Increased Brain Drug Bioavailability". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/10/1424.
    10.3390/ph16101424
  5. Ana Cláudia Paiva-Santos; Tatiana Gonçalves; Diana Peixoto; Patrícia C. Pires; K. Velsankar; Niraj Kumar Jha; Vivek Chavda; et al. "Rosacea Topical Treatment and Care: From Traditional to New Drug Delivery Systems". Molecular Pharmaceutics 20 8 (2023): 3804-3828. http://dx.doi.org/10.1021/acs.molpharmaceut.3c00324.
    10.1021/acs.molpharmaceut.3c00324
  6. Patrícia C. Pires; Mariana Fernandes; Francisca Nina; Francisco Gama; Maria F. Gomes; Lina E. Rodrigues; Sara Meirinho; et al. "Innovative Aqueous Nanoemulsion Prepared by Phase Inversion Emulsification with Exceptional Homogeneity". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/7/1878.
    10.3390/pharmaceutics15071878
  7. Beatriz P. Ferreira; Gustavo Costa; Filipa Mascarenhas-Melo; Patrícia C. Pires; Fariba Heidarizadeh; Prabhanjan S. Giram; Priscila Gava Mazzola; et al. "Skin applications of cannabidiol: sources, effects, delivery systems, marketed formulations and safety". Phytochemistry Reviews 22 3 (2023): 781-828. http://dx.doi.org/10.1007/s11101-023-09860-5.
    10.1007/s11101-023-09860-5
  8. Ana Margarida Alves; Margarida C. Gonçalves; Matilde Marques; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "In Vitro Models for Anti-Aging Efficacy Assessment: A Critical Update in Dermocosmetic Research". Cosmetics (2023): https://www.mdpi.com/2079-9284/10/2/66.
    10.3390/cosmetics10020066
  9. Omolbanin Badalkhani; Patrícia C. Pires; Maryam Mohammadi; soraya babaie; Ana Cláudia Paiva-Santos; Hamed Hamishehkar. "Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/5/670.
    10.3390/ph16050670
  10. Patrícia C. Pires; Filipa Mascarenhas-Melo; Kelly Pedrosa; Daniela Lopes; Joana Lopes; Ana Macário-Soares; Diana Peixoto; et al. "Polymer-based biomaterials for pharmaceutical and biomedical applications: A focus on topical drug administration". European Polymer Journal 187 (2023): 111868-111868. http://dx.doi.org/10.1016/j.eurpolymj.2023.111868.
    10.1016/j.eurpolymj.2023.111868
  11. Gabriel Martínez-Razo; Patrícia C. Pires; María Lilia Domínguez-López; Francisco Veiga; Armando Vega-López; Ana Cláudia Paiva-Santos. "Norcantharidin Nanoemulsion Development, Characterization, and In Vitro Antiproliferation Effect on B16F1 Melanoma Cells". Pharmaceuticals (2023): https://www.mdpi.com/1424-8247/16/4/501.
    10.3390/ph16040501
  12. Jéssica Lopes Antunes; Joana Amado; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Nanosystems, Drug Molecule Functionalization and Intranasal Delivery: An Update on the Most Promising Strategies for Increasing the Therapeutic Efficacy of Antidepressant and Anxiolytic Drugs". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/3/998.
    10.3390/pharmaceutics15030998
  13. Laura Ferreira; Patrícia C. Pires; Mariana Fonseca; Gustavo Costa; Dr. Prabhanjan Giram; Priscila Mazzola; victoria bell; et al. "Nanomaterials in Cosmetics: An Outlook for European Regulatory Requirements and a Step Forward in Sustainability". Cosmetics (2023): https://www.mdpi.com/2079-9284/10/2/53.
    10.3390/cosmetics10020053
  14. Maria Daniela Ferreira; Joana Duarte; Francisco Veiga; Ana Cláudia Paiva-Santos; Patrícia C. Pires. "Nanosystems for Brain Targeting of Antipsychotic Drugs: An Update on the Most Promising Nanocarriers for Increased Bioavailability and Therapeutic Efficacy". Pharmaceutics (2023): https://www.mdpi.com/1999-4923/15/2/678.
    10.3390/pharmaceutics15020678
  15. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Nano and Microemulsions for the Treatment of Depressive and Anxiety Disorders: An Efficient Approach to Improve Solubility, Brain Bioavailability and Therapeutic Efficacy". Pharmaceutics 14 12 (2022): 2825-2825. http://dx.doi.org/10.3390/pharmaceutics14122825.
    10.3390/pharmaceutics14122825
  16. Margarida Alberto; Ana Cláudia Paiva-Santos; Francisco Veiga; Patrícia C. Pires. "Lipid and Polymeric Nanoparticles: Successful Strategies for Nose-to-Brain Drug Delivery in the Treatment of Depression and Anxiety Disorders". Pharmaceutics 14 12 (2022): 2742-2742. http://dx.doi.org/10.3390/pharmaceutics14122742.
    10.3390/pharmaceutics14122742
  17. Joana Lopes; Daniela Lopes; Ana Macário-Soares; Inês Ferreira-Faria; Diana Peixoto; Mahzad Motallebi; Imran Mohammad; et al. "Cell Membrane-Coated Biomaterials for Bone Cancer-Targeted Diagnosis and Therapy: A Critical Update on Osteosarcoma Applications". Materials Chemistry Horizons (2022): https://doi.org/10.22128/mch.2022.615.1032.
    10.22128/mch.2022.615.1032
  18. Patrícia C. Pires; Ana Cláudia Paiva-Santos; Francisco Veiga. "Antipsychotics-Loaded Nanometric Emulsions for Brain Delivery". Pharmaceutics 14 10 (2022): 2174-2174. http://dx.doi.org/10.3390/pharmaceutics14102174.
    10.3390/pharmaceutics14102174
  19. Patrícia C. Pires. "C-Ring Oxidized Estrone Acetate Derivatives: Assessment of Antiproliferative Activities and Docking Studies". Applied Sciences 12 7 (2022): 3579-3579. http://dx.doi.org/10.3390/app12073579.
    10.3390/app12073579
  20. Patrícia C. Pires. "Strategies to Improve Drug Strength in Nasal Preparations for Brain Delivery of Low Aqueous Solubility Drugs". Pharmaceutics 14 3 (2022): 588-588. http://dx.doi.org/10.3390/pharmaceutics14030588.
    10.3390/pharmaceutics14030588
  21. "Nose-to-brain delivery of phenytoin and its hydrophilic prodrug fosphenytoin combined in a microemulsion - formulation development and in vivo pharmacokinetics.". European Journal of Pharmaceutical Sciences 164 (2021): 105918-105918. http://dx.doi.org/10.1016/j.ejps.2021.105918.
    10.1016/j.ejps.2021.105918
  22. Pires, Patrícia C.; Santos, Liliana T.; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Intranasal fosphenytoin: The promise of phosphate esters in nose-to-brain delivery of poorly soluble drugs". International Journal of Pharmaceutics 592 (2021): http://dx.doi.org/10.1016/j.ijpharm.2020.120040.
    Published • 10.1016/j.ijpharm.2020.120040
  23. Pires, Patrícia C.; Peixoto, Diana; Teixeira, Isaura; Rodrigues, Márcio; Alves, Gilberto; Santos, Adriana O.. "Nanoemulsions and thermosensitive nanoemulgels of phenytoin and fosphenytoin for intranasal administration: Formulation development and in vitro characterization". European Journal of Pharmaceutical Sciences 141 (2020): http://dx.doi.org/10.1016/j.ejps.2019.105099.
    Published • 10.1016/j.ejps.2019.105099
  24. Pires, Patrícia C.; Santos, Adriana O.. "Nanosystems in nose-to-brain drug delivery: A review of non-clinical brain targeting studies". Journal of Controlled Release 270 (2018): 89-100. http://dx.doi.org/10.1016/j.jconrel.2017.11.047.
    Published • 10.1016/j.jconrel.2017.11.047
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/11 Intranasal administration of fosphenytoin: assay development and validation and preliminary in vivo pharmacokinetic studies III International Congress in Health Sciences Research
(Covilhã, Portugal)
2019/07 Formulation development and in vitro characterization of nanoemulsions and nanoemulgels of phenytoin and fosphenytoin for intranasal administration XIV Annual CICS-UBI Symposium
(Covilhã, Portugal)
2018/07 Thermosensitive and mucoadhesive polymers in intranasal drug delivery: fosphenytoin formulation development and characterization XIII Annual CICS-UBI Symposium
(Covilhã, Portugal)
2017 Modifications of estrone in C- and D-ring: synthesis, biological evaluation and docking studies XLVII Reunião Anual da Sociedade Portuguesa de Farmacologia
(Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2020 - 2021 Eficácia da administração intranasal de micro e nanoemulsões na biodisponibilidade e direcionamento cerebral de fármacos de baixa massa molecular
Co-supervisor
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2020 - 2021 Otimização de nanoemulsões óleo-em-água com caraterísticas ideais de composição e tamanho de gotícula
Co-supervisor
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2019 - 2021 Formulação de emulsões nanométricas de fenitoina e fosfenitoina
Co-supervisor of Ana C. Fazendeiro
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2019 - 2020 Revisão de modelos de epitélio nasal humano nos estudos pré-clínicos de segurança
Co-supervisor of Iryna Denysyuk
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018 - 2019 Avaliação da libertação de fosfenitoína em preparações líquidas mucoadesivas ou termossensíveis
Co-supervisor of Liliana T. Santos
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
2018 - 2019 Revisão da aplicação clínica de benzodiazepinas pela via intranasal no tratamento da epilepsia
Co-supervisor of Dora Melo
 Pharmaceutical Sciences (Master)
Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal
Distinctions

Award

2019 Best Oral Communication in the "III International Congress in Health Sciences Research", Covilhã, Portugal
Universidade da Beira Interior Instituto Coordenador da Investigação, Portugal