???global.info.a_carregar???
Filipe Monteiro is a neurodevelopmental biologist. He graduated in Biology at University of Aveiro in 2000 and concluded his PhD in Biomedical Sciences at University of Porto in 2006. Currently, he is an Assistant Professor at the Faculty of Medicine, University of Porto, and a researcher in the Pain Neurobiology group at i3S Research Institute, University of Porto. At the teaching level, Filipe Monteiro has been and teaching courses related to Cell and Molecular Biology and entry-level bioinformatics. He is continuously participating in learning innovation courses and is a member of the follow-up commission of MSc in Neurobiology (since 2017). He is responsible for post-graduation course Molecular Bioinformatics, Hands-on Course (2 ECTS, ongoing since 2017), and participates as faculty member in the Essential Molecular Biology course (6 ECTS, ongoing since 2012). At the research level, he has co-authored 11 papers in peer-reviewed journals (WoS indexed), H-index of 7 and 171 citations, with average journal index factor above 4 (73% of them is in the first JIF quartile). He supervised 1 PhD thesis, 9 MSc thesis, and 8 BSc thesis. He was enrolled in 6 FCT funded projects as team member and 3 project awards as principal investigator.
Read full resume ↓
Identification

Personal identification

Full name
Filipe Almeida Monteiro

Citation names

  • Monteiro, Filipe A

Author identifiers

Ciência ID
E012-1F97-09F1
ORCID iD
0000-0003-0670-3658

Email addresses

  • filipem@med.up.pt (Professional)

Telephones

Fax
  • 225513655 (Professional)
Telephone
  • 225513654 (Professional)

Addresses

  • Faculdade de Medicina da Universidade do Porto, Departamento de Biomedicina, piso 4. Alameda Hernâni Monteiro, 4200-319 , Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2001/11/01 - 2006/11/02
Concluded
 Ciências Biomédicas (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Insights on Signal Transduction Pathways Involved in Familial Amyloidotic Polineuropathy Neurodegeneration" (THESIS/DISSERTATION)
 Approved
1995/09/01 - 2000/07/19
Concluded
 Biologia (Licenciatura)
Major in Não Aplicável
Universidade de Aveiro, Portugal
"Genetic analysis of the replication of the polydnavirus ccpdv in the ovaries of the parasitoid wasp Cotesia congregate" (THESIS/DISSERTATION)
 15/20
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2019/07/01 - Current Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2008/06/02 - 2019/06/30 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal

Others

Category
Host institution 		Employer
2006/11/03 - 2010/09/14 Post doctoral fellow (SFRH/BPD/26643/2006) of Fundação Ciência e Tecnologia (FCT); Supervisor: Deolinda Lima Universidade do Porto Faculdade de Medicina, Portugal
2001/11/01 - 2006/10/31 PhD fellow (SFRH/BD/4563/2001) of FCT; Supervisor: Maria João Saraiva; Co-supervisor: Mónica Mendes Sousa Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2000/09/01 - 2001/10/31 Young Research Scientist fellow of FCT; Supervisor: Maria João Saraiva Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2001/02/01 - 2001/07/31 Luso-American Development Fundation (FLAD) fellow; Supervisors: David Stern and Maria João Saraiva Columbia University College of Physicians and Surgeons, United States
2000/03/01 - 2000/07/31 Undergraduate student (dissertation thesis) with an ERASMUS Scholarship; Supervisor: Jean-Michel Drezen Université de Tours, France
1995/09/01 - 2000/07/31 Student of Biology degree Universidade de Aveiro, Portugal
Projects

Grant

Designation Funders
2013/05 - 2015/12 Molecular mechanisms of chronic pain: an integrated approach based on genetically manipulated animal models
Provided by PTCRIS: 125590
 Fundação para a Ciência e a Tecnologia
2013/07 - 2015/01 Finding new Pain-genes: whole-exome sequencing of human patients.
Provided by PTCRIS: 125755
 Fundação para a Ciência e a Tecnologia
2010/04 - 2013/09 Mecanismos moleculares que modulam a acção do Prrxl1 no desenvolvimento dos neurónios nociceptivos
Provided by PTCRIS: PTDC/SAU-OBD/099886/2008
 Fundação para a Ciência e a Tecnologia
2006/11 - 2010/08 MOLECULAR PATHWAYS REGULATED BY DRG11 IN NOCICEPTIVE SYSTEM DEVELOPMENT
Provided by PTCRIS: SFRH/BPD/26643/2006
 Fundação para a Ciência e a Tecnologia
2005/09 - 2007/10 Molecular pathology of familial amyloid polyneuropathy
Provided by PTCRIS: 56929
 Fundação para a Ciência e a Tecnologia
2001/11 - 2005/10 TRANSDUCTION PATHWAYS INVOLVED IN FAP NEURODEGENERATION
Provided by PTCRIS: SFRH/BD/4563/2001
 Fundação para a Ciência e a Tecnologia

Contract

Designation Funders
2013/05 - 2015/12 Molecular mechanisms of chronic pain: an integrated approach based on genetically manipulated animal models
RECI/NEU-NMC/0138/2012
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/07 - 2015/01 Finding new Pain-genes: whole-exome sequencing of human patients.
EXPL/BIM-MEC/0415/2012
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/04 - 2013/09 Molecular mechanisms modulating Prrxl1-mediated development of pain-processing neurons
PTDC/SAU-OBD/099886/2008
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2012/09/01 - 2013/08/31 Unraveling Prrxl1 transcriptional program in nociceptors of the dorsal root ganglia
PP_IJUP2011 156
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal
 Banco Santander Portugal
Concluded
2008/06/01 - 2011/05/31 Unravelling the assembly of the nociceptive system circuitry along mouse development by identifying Prrxl1 target genes
FGC_PAIFCV_2007
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação Calouste Gulbenkian
Concluded
2009/09/01 - 2010/08/31 Role of phosphorylation in regulating Prrxl1 transcription factor activity
PP_IJUP2009
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal
 Banco Santander Portugal
Concluded
2005/09 - 2007/10 Molecular pathology of familial amyloid polyneuropathy
POCI/SAU-OBS/56929/2004
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Conference abstract
  1. Santos-Pereira M; Silva S; Santos-Leite L; Monteiro F; Summavielle T; Cruz F; Charrua A. "REFINEMENT OF ANIMAL MODELS TO STUDY BPS/IC". Paper presented in 7th June 2023 record of a meeting at Bristol University, Bristol, 2023.
    10.1002/nau.25315
  2. M Santos-Pereira; S Silva; L Santos-Leite; F Monteiro; T Summavielle; F Cruz; A Charrua. "STRESS-INDUCED MORPHOLOGICAL AND FUNCTIONAL CHANGES IN THE FEMALE RAT INSULA. REFINEMENT OF NON-BLADDER CENTRIC PAINFUL BLADDER SYNDROME EXPERIMENTAL MODELS". Paper presented in ICS 2023 Toronto Abstracts, Toronto, 2023.
    10.1016/j.cont.2023.100759
  3. M. Santos-Pereira; S. Silva; L. Santos-Leite; A.I. Silva; A.F. Terceiro; C. Pinto; T. Canedo; et al. "The insula, a key brain area for bladder pain control, is modulated by stress". 2023.
    10.1016/s0302-2838(23)00805-9
  4. Monteiro, Filipe. "Modulation of Prrxl1 transcriptional activity by phosphorylation". Paper presented in International Conference for Healthcare and Medical Students, Dublin, 2012.
    10.1186/1753-6561-6-s4-o47
  5. I. Regadas; F. Monteiro; S. Rebelo; D. Lima; C. Reguenga. "Two regulatory elements with opposite effects modulate the activity of prrxl1 alternative promoters". Paper presented in 18th Biennial Meeting of the International Society for Developmental Neuroscience, Estoril, 2010.
    10.1016/j.ijdevneu.2010.07.127
  6. Monteiro, Filipe. "Prrxl1 expression in mouse nociceptive neurons is controlled by alternative promoters". Paper presented in 69th Annual Meeting of the Society-for-Developmental-Biology/Japanese-Society-of-Developmental-Biologists, 2010.
    10.1016/j.ydbio.2010.05.443
  7. Monteiro, Filipe; Reguenga, Carlos; Guillemot, Francois; Castro, Diogo S.; Lima, Deolinda. "Evidence for autoregulation of the homeodomain transcription factor Prrxl1". Paper presented in 16th International Society of Developmental Biologists Congress 2009, Edinburgh, 2009.
    Published • 10.1016/j.mod.2009.06.217
  8. Regadas, I; Monteiro, Filipe; Rebelo, Sandra; Lima, Deolinda; Reguenga, Carlos. "Identification of regulatory elements modulating PRRXL1/DRG11 transcription during the development of pain-processing neurons". Paper presented in 11th Meeting of the Portuguese Society for Neuroscience, Braga, 2009.
    Published • 10.3389/conf.neuro.01.2009.11.132
  9. Monteiro, Filipe; Reguenga, Carlos; Guillemot, Francois; Castro, Diogo S.; Lima, Deolinda. "PRRXl1 Homeodomain Transcription Factor Binds to its Own Promoter in Vivo". Paper presented in 11th Meeting of the Portuguese Society for Neuroscience, Braga, 2009.
    Published • 10.3389/conf.neuro.01.2009.11.133
  10. Monteiro, Filipe. "Prrxl1 expression is upregulated upon differentiation in neuronal cells". 2008.
    10.1016/j.ydbio.2008.05.381
Journal article
  1. João Baltar; Rafael Mendes Miranda; Maria Cabral; Sandra Rebelo; Florian Grahammer; Tobias B. Huber; Carlos Reguenga; Filipe Almeida Monteiro. "Neph1 is required for neurite branching and is negatively regulated by the PRRXL1 homeodomain factor in the developing spinal cord dorsal horn". Neural Development (2024): http://dx.doi.org/10.1186/s13064-024-00190-6.
    10.1186/s13064-024-00190-6
  2. Monteiro, Filipe A.; Miranda, Rafael M.; Samina, Marta C.; Dias, Ana F.; Raposo, Alexandre A. S. F.; Oliveira, Patrícia; Reguenga, Carlos; Castro, Diogo S.; Lima, Deolinda. "Tlx3 Exerts Direct Control in Specifying Excitatory Over Inhibitory Neurons in the Dorsal Spinal Cord". Frontiers in Cell and Developmental Biology 9 (2021): http://dx.doi.org/10.3389/fcell.2021.642697.
    10.3389/fcell.2021.642697
  3. Ramos, Helena; Soares, Maria I.L.; Silva, Joana; Raimundo, Liliana; Calheiros, Juliana; Gomes, Célia; Reis, Flávio; et al. "A selective p53 activator and anticancer agent to improve colorectal cancer therapy". Cell Reports 35 2 (2021): 108982. http://dx.doi.org/10.1016/j.celrep.2021.108982.
    10.1016/j.celrep.2021.108982
  4. Soares-Dos-Reis, R.; Sofia Pessoa, A.; Dias, A.F.; Falcão, M.; Matos, M.R.; Vitorino, R.; Monteiro, F.A.; et al. "A role for prolyl isomerase PIN1 in the phosphorylation-dependent modulation of PRRXL1 function". Biochemical Journal 474 5 (2017): 683-697. http://www.scopus.com/inward/record.url?eid=2-s2.0-85014580896&partnerID=MN8TOARS.
    10.1042/BCJ20160560
  5. Monteiro, C.B.; Midão, L.; Rebelo, S.; Reguenga, C.; Lima, D.; Monteiro, F.A.. "Zinc finger transcription factor Casz1 expression is regulated by homeodomain transcription factor Prrxl1 in embryonic spinal dorsal horn late-born excitatory interneurons". European Journal of Neuroscience (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84960977317&partnerID=MN8TOARS.
    10.1111/ejn.13214
  6. Monteiro CB; Costa MF; Reguenga C; Lima D; Castro DS; Monteiro FA. "Paired related homeobox protein-like 1 (Prrxl1) controls its own expression by a transcriptional autorepression mechanism.". (2014): http://europepmc.org/abstract/med/25131932.
    10.1016/j.febslet.2014.08.006
  7. Regadas I; Soares-Dos-Reis R; Falcão M; Matos MR; Monteiro FA; Lima D; Reguenga C. "Dual role of Tlx3 as modulator of Prrxl1 transcription and phosphorylation.". (2014): http://europepmc.org/abstract/med/25138281.
    10.1016/j.bbagrm.2014.08.007
  8. Soares-dos-Reis R; Pessoa AS; Matos MR; Falcão M; Mendes VM; Manadas B; Monteiro FA; Lima D; Reguenga C. "Ser¹¹¿ phosphorylation modulates the activity and conformation of PRRXL1, a homeodomain transcription factor.". (2014): http://europepmc.org/abstract/med/24564673.
    10.1042/BJ20131014
  9. Regadas I; Matos MR; Monteiro FA; Gómez-Skarmeta JL; Lima D; Bessa J; Casares F; Reguenga C. "Several cis-regulatory elements control mRNA stability, translation efficiency, and expression pattern of Prrxl1 (paired related homeobox protein-like 1).". (2013): http://europepmc.org/abstract/med/24214975.
    10.1074/jbc.M113.491993
  10. Monteiro, F.A.; Sousa, M.M.; Cardoso, I.; Do Amaral, J.B.; Guimarães, A.; Saraiva, M.J.. "Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy". Journal of Neurochemistry 97 1 (2006): 151-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-33644951055&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2006.03716.x
  11. Monteiro, F.A.; Cardoso, I.; Sousa, M.M.; Saraiva, M.J.. "In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE)". FEBS Letters 580 14 (2006): 3451-3456. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646925693&partnerID=MN8TOARS.
    10.1016/j.febslet.2006.05.020
  12. Pasquier-Barre, F.; Dupuy, C.; Huguet, E.; Monteiro, F.; Moreau, A.; Poirié, M.; Drezen, J.-M.. "Polydnavirus replication: The EP1 segment of the parasitoid wasp Cotesia congregata is amplified within a larger precursor molecule". Journal of General Virology 83 8 (2002): 2035-2045. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036323962&partnerID=MN8TOARS.
    10.1099/0022-1317-83-8-2035
Thesis / Dissertation
  1. "Insights on Signal Transduction Pathways Involved in Familial Amyloidotic Polyneuropathy Neurodegeneration". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2006.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2018/12/01 - Current Dissecting the function of Neph1 in the dorsal root ganglion-spinal circuits
Co-supervisor
 Programa Doutoral em Neurociências (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2022/09/01 - 2023/12/14 Dissecting the transcriptional program of Prrxl1 transcription factor in the development of dorsal root ganglion nociceptors
Supervisor
 Genética Molecular (Master)
Universidade do Minho Escola de Ciências, Portugal
2022/09/01 - 2023/11/29 The role of phosphorylation at Ser119 in the regulation of PRRXL1 transcriptional activity in spinal glutamatergic neurons
Co-supervisor
 Neurobiologia (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2020/09/01 - 2021/11/24 Insight into the differentiation of spinal dorsal horn neurons
Supervisor
 Mestrado em Neurobiologia (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2019/09/01 - 2020/12/04 Prrxl1 controls the expression of transmitter and transmitter receptor genes in developing dorsal spinal cord
Supervisor
 Mestrado em Neurobiologia (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2017/09/01 - 2018/05/14 Neurogénese no adulto: contribuições de organismos modelo genético
Supervisor
 Mestrado Integrado em Medicina (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2016/09/01 - 2017/12/11 Insight into Neph 1 transcriptional regulation and expression pattern in the dorsal root ganglion-spinal cord circuitry
Supervisor
 Mestrado em Neurobiologia (Master)
Universidade do Porto Faculdade de Medicina, Portugal
2011/10/01 - 2016/12/14 Prrxl1 and Casz1 transciptional regulation in the development of the DRG-spinal nociceptive circuitry
Co-supervisor
 Programa Doutoral em Neurociências (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2012/09/01 - 2013/12/02 Insight into Prrxl1 transcriptional program in developing nociceptors of the dorsal root ganglia
Supervisor
 Mestrado em Bioquímica (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2010/09/01 - 2011/07/11 Insights into the molecular basis of Prrxl1 function
Supervisor
 Mestrado em Biologia Aplicada (Master)
Universidade de Aveiro, Portugal
2008/09/01 - 2009/12/23 Expression analysis of Prrxl1 transcription factor isoforms during the establishment of the nociceptive system
Supervisor
 Mestrado em Biologia (Master)
Universidade do Porto Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/02/23 Phosphorylation mediated events in biomarker discovery for Alzheimer’s disease
(Thesis) Main arguer
 Joana Machado de Oliveira (PhD)
Universidade de Aveiro, Portugal
2017/09/27 Implementation of Mammalian two-hybrid system for high throughput drugs screening
(Thesis) Arguer
 Daniela Marques Patrício (Master)
Universidade de Aveiro Departamento de Biologia, Portugal
2012/10/24 PP1 Interactomes as a means of characterizing protein functions
Thesis Member
 Sara Luísa de Castro Esteves (PhD)
2011/07/07 Synaptosomal signal transduction in Alzeimer’s disease
(Thesis) Arguer
 Edgar Duarte de Jesus Valente Marques Coelho (Master)
Universidade de Aveiro, Portugal
2010 Inhibitor-2L, a novel putative protein phosphatase inhibitor in human sperm
(Thesis) Arguer
 Mónica Alexandra dos Santos Ferreira (Master)
Universidade de Aveiro Departamento de Biologia, Portugal

Association member

Society Organization name Role
2015 - Current Portuguese Society for Neuroscience (SPN) Effective Member
Distinctions

Award

2011 Programa Projetos Pluridisciplinares para Iniciação à Investigação
Banco Santander Portugal, Portugal
2009 Programa Projetos Pluridisciplinares para Iniciação à Investigação
Banco Santander Portugal, Portugal
2008 Programa de Apoio à Investigação na Fronteira das Ciências da Vida
Fundação Calouste Gulbenkian, Portugal

Other distinction

2008 Travel grant award
Fundação Calouste Gulbenkian, Portugal
2000 Travel Grant Award
Fundação Luso-Americana, Portugal