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Carmen Brás-Silva is an Assistant Professor at the Faculty of Medicine of the University of Porto. She obtained her PhD in Human Biology from the University of Porto, Portugal, in April 2007. She is a member of the Associated Laboratory RISE - Health Research Network and of the UnIC - Cardiovascular R&D Centre, and she leads the research line on Pulmonary Hypertension and Right Ventricular Function at UnIC. Her current research interests mainly focus on integrative cardiovascular physiology, particularly the study of pharmacological and nutritional modulation of cardiopulmonary pathophysiology. Specifically, her research interests include: - Investigating cardiac autocrine/paracrine activation in pulmonary arterial hypertension and heart failure. - Exploring the role, underlying signal transduction pathways, and potential therapeutic properties of novel neurohumoral factors (e.g., neuregulin, urocortin), as well as antimiR strategies, in addition to well-known systems (ET-1, Ang II), in the context of pulmonary hypertension and the progression to right and left ventricular dysfunction. She has contributed to over 50 scientific publications (full-text) in the cardiovascular field and has been involved in 37 National and European research projects, 17 of which as a Principal Investigator.
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Identification

Personal identification

Full name
Carmen Dulce Silveira Brás Silva Ribeiro

Citation names

  • Brás-Silva, Carmen
  • Brás Silva, Carmen
  • Bras-Silva, C

Author identifiers

Ciência ID
E117-E5D1-B239
ORCID iD
0000-0003-1527-3776
Google Scholar ID
https://scholar.google.pt/citations?user=Q2lhol0AAAAJ&hl=en-EN
Researcher Id
J-3754-2013
Scopus Author Id
7801357838

Email addresses

  • carmensb@med.up.pt (Professional)

Addresses

  • Faculdade de Medicina da Universidade do Porto . Departamento de Cirurgia e Fisiologia,Al. Prof. Hernâni Monteiro, 4200-319, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Physiology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics
Education
Degree Classification
2007/04/13
Concluded
 Doutoramento em Biologia Humana / PhD in Human Biology (Doutoramento)
Major in Pathophysiology of heart failure
Universidade do Porto Faculdade de Medicina, Portugal
"Myocardial ET-1 effects and their implications in the pathophysiology of heart failure" (THESIS/DISSERTATION)
 magna cum laude
1999/01/11
Concluded
 Degree in Nutritional Sciences (Licenciatura)
Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
"Nutrição e massa óssea / Nutrition and Bone Mass" (THESIS/DISSERTATION)
 15 (out of 20)
Affiliation

Science

Category
Host institution 		Employer
2014/09/01 - 2015/09/30 Invited Principal Investigator (Research) Universidade do Porto Faculdade de Medicina, Portugal
2009/07/01 - 2014/06/30 Invited Auxiliary Researcher (Research) Universidade do Porto Faculdade de Medicina, Portugal
2008 - 2013 Invited Auxiliary Researcher (Research) Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2017/09/01 - Current Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Faculdade de Medicina, Portugal
2017/09/01 - Current Visiting Professor (University Teacher) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2016 - 2017 Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2014 - 2016 Adjunct Teacher (Polytechnic Teacher) Escola Superior de Enfermagem do Porto, Portugal

Others

Category
Host institution 		Employer
2015/09/30 - 2017/08/31 Invited Assistant Professor (60%) Universidade do Porto Faculdade de Medicina, Portugal
2007/09/01 - 2017/01/31 Invited Assistant Professor (30%) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2007/05/01 - 2009/06/30 Postdoc Researcher Universidade do Porto Faculdade de Medicina, Portugal
2000/10/01 - 2009/06/30 Invited teacher of Physiology Escola Superior de Enfermagem do Porto, Portugal
2004/12/02 - 2007/08/31 Invited Assistant Professor of Physiology Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2004/12/02 - 2007/08/31 Invited Assistant Professor of Physiology Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2003/03/01 - 2007/04/13 PhD student Universidade do Porto Faculdade de Medicina, Portugal
1997/09/01 - 1998/08/31 Training in Nutrition Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
1997/09/01 - 1998/08/31 Training in Clinical Nutrition Hospital de São João, Portugal
Projects

Grant

Designation Funders
2020/01/01 - 2022/12/31 Epidermal growth factor receptor 4 activation in pulmonary arterial hypertension
Robalo Cordeiro SPP/Novartis 2019 Award ( ex-aequo)
Researcher
Sociedade Portuguesa de Pneumologia
Ongoing
2018/01/01 - 2020/12/31 Microrna-146a is implicated in the development of pulmonary hypertension – human and experimental insights.
1st Prize Thomé Villar/ Boehringer Ingelheim 2017
Principal investigator
Sociedade Portuguesa de Pneumologia
Ongoing
2017/01/01 - 2019/12/31 MicroRNA-146a is implicated in the development of pulmonary hypertension
Prémio/ Award Robalo Cordeiro – SPP/Novartis 2016
Prémio/ Award Robalo Cordeiro SPP/Novartis 2016
Prémio/ Award Robalo Cordeiro – SPP/Novartis 2016
Principal investigator
Sociedade Portuguesa de Pneumologia
Concluded
2017/01/01 - 2019/12/31 Urocortin-2 attenuates pulmonary arterial hypertension
1st Prize Thomé Villar/ Boehringer Ingelheim 2016
Principal investigator
Sociedade Portuguesa de Pneumologia
Concluded
2017/05/01 - 2019/04/30 The role of urocortin-2 in heart failure with preserved ejection fraction -pathophysiological and therapeutic implicationss
Bolsa de Estudo João Porto, 2016
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal
 Sociedade Portuguesa de Cardiologia
Concluded
2016/01/01 - 2018/12/31 Pathophysiological role of mir-146a in pulmonary arterial hypertension – therapeutic implications
Robalo Cordeiro Award– SPP/Novartis 2015 , Portuguese Society of Pulmonology /Novartis
Robalo Cordeiro Award SPP/Novartis 2015 , Portuguese Society of Pulmonology /Novartis
Principal investigator
N/A
Concluded
2016/01/01 - 2018/12/31 Neuregulin-1 improves right ventricular function and attenuates experimental pulmonar arterial hypertension
1st Prize Thomé Villar/ Boehringer Ingelheim 2015, Portuguese Society of Pulmonology
Principal investigator
Sociedade Portuguesa de Pneumologia
Concluded
2017/05/01 - 2018/04/30 MicroRNA-146a role in pulmonary arterial hypertension and in right ventricular dysfunction
Servier Award in Heart Failure - basic research
Principal investigator
Concluded
2014/05/01 - 2016/04/30 The role of miRNA-146a in pulmonary hypertension
Bolsa de Estudo João Porto 2013, Portuguese Society of Cardiology
Principal investigator
Sociedade Portuguesa de Cardiologia
Concluded
2014/05/01 - 2015/04/30 Neuregulin-1 attenuates pulmonary arterial hypertension and right ventricular dysfunction in an experimental model of pulmonary hypertension
Award Servier in Heart Failure – Basic Research – 2013
Award Servier in Heart Failure Basic Research 2014
Award Servier in Heart Failure ¿ Basic Research ¿ 2014
Award Servier in Heart Failure Basic Research 2013
Principal investigator
Sociedade Portuguesa de Cardiologia
Concluded
2013/01/01 - 2013/12/31 Therapeutic potential of urocortin-2 system in pulmonary hypertension
IJUP 2013, Projetos Pluridisciplinares UP, Universidade do Porto/Santander Totta
Principal investigator
Concluded
2011/01/01 - 2011/12/31 ErbB receptor stimulation - a therapeutic approach in pulmonary hypertension.
IJUP 2011, Projetos Pluridisciplinares UP, Universidade do Porto/Santander Totta
Principal investigator
Universidade do Porto
Concluded
2009/05/01 - 2011/04/30 The role of neuregulin system in the pathophysiology of pulmonary hypertension and in the progression to heart failure
Bolsa de Estudo João Porto 2008-2009 - Portuguese Society of Cardiology
Principal investigator
Sociedade Portuguesa de Cardiologia
Concluded
2009/09/01 - 2010/08/31 Pathophysiological role of the neuregulin system in pulmonary hypertension
IJUP 2009, Projectos Pluridisciplinares UP
Principal investigator
Universidade do Porto
Concluded
2007/05/01 - 2009/06/30 FISIOPATOLOGIA DA HIPERTENSÃO PULMONAR: DESENVOLVIMENTO DE MODELOS EXPERIMENTAIS, MODULAÇÃO FARMACOLÓGICA E NUTRICIONAL
SFRH/BPD/34568/2007
Universidade do Minho, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2003/03/01 - 2007/02/28 EFEITOS MIOCÁRDICOS DA ENDOTELINA-1 E SUAS IMPLICAÇÕES NA FISIOPATOLOGIA DA INSUFICIÊNCIA CARDÍACA
SFRH/BD/10249/2002
 Fundação para a Ciência e a Tecnologia
Concluded
1998/10/01 - 2000/06/30 MECANISMOS NEUROHUMURAIS E ENDOTELIAIS NA INSUFICIÊNCIA CARDÍACA
PRAXIS XXI/BTI/17274/98
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Health Research Network: From Lab to Community Health
LA/P/0053/2020
Universidade do Porto Faculdade de Medicina, Portugal

Centro de Investigação em Tecnologias e Serviços de Saúde, Portugal

Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade Nova de Lisboa, Portugal

Escola Superior de Enfermagem do Porto, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil EPE, Portugal

Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal

Universidade de Aveiro, Portugal

Universidade da Madeira, Portugal

Universidade do Algarve, Portugal

Associação para a Investigação e Desenvolvimento da Faculdade de Medicina, Portugal

Universidade de Lisboa Centro Cardiovascular da Universidade de Lisboa, Portugal

Universidade do Porto Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2024/12/31 UnIC - Unidade de Investigação e Desenvolvimento Cardiovascular/ Cardiovascular Research and Development Center (UIDB/00051/2020)
UIDB/00051/2020
Researcher
Fundação para a Ciência e a Tecnologia
Ongoing
2023/03/12 - 2024/09/11 Relaxin-2 and Pulmonary Arterial Hypertension: pathophysiological role and therapeutic potential
2022.08921.PTDC
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/01 - 2022/06/30 IMPAcT - Insight in the pathophysiological role of Mir-146a in Pulmonary Arterial hypertension - Therapeutic implications
PTDC/MED-FSL/31719/2017
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon)
Ongoing
2016/05/01 - 2020/11/30 DOCnet -Diabetes & obesity at the crossroads between Oncological and Cardiovascular diseases – a system analysis NETtwork towards precision medicine
Operação nºNORTE-01-0145-FEDER-000003
Researcher
Comissao de Coordenacao e Desenvolvimento Regional do Norte
Ongoing
2016/12/01 - 2020/05/31 NETDIAMOND – New Targets in DIAstolic heart failure: from comorbidities to personalized medicine
SAICTPAC/00 47/2015
Researcher
Ongoing
2019/01/01 - 2019/12/31 Cardiovascular Research and Development Center
UID/IC/00051/2019
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016/07/01 - 2019/01/01 CAST - CArdiac measuring Shirt for Telemedicine
E!10291
Researcher
Eurostars
Concluded
2015/01/01 - 2018/12/31 Unidade de Investigação e Desenvolvimento Cardiovascular/ Cardiovascular Research and Development Center (UID/IC/00051/2013)
UID/IC/00051/2013
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2013/01/01 - 2015/12/31 Diastolic heart failure: unraveling novel pathophysiologic mechanisms as potential therapeutic targets
Provided by PTCRIS: 124776
124776
FCOMP-01-0124-FEDER-027386 (Refª. FCT EXCL/BIM-MEC/0055/2012)
Researcher
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
Concluded
2011/01/01 - 2015/12/31 MEDIA - The MEtabolic Road to DIAstolic Heart Failure
EU FP7-HEALTH-2010 - 2.4.2-4
Researcher
European Commission Seventh Framework Programme for Research and Technological Development Health
Concluded
2013/07/01 - 2015/10/31 Pathophysiological role and therapeutic potential of urocortin 2 in pulmonary hypertension
Provided by PTCRIS: 124203
124203
FCOMP-01-0124-FEDER-028695 (Refª. FCT PTDC/DTP-FTO/0130/2012
Principal investigator
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/07/01 - 2015/09/30 On the role of adenosine signalling in the progression of pulmonary hypertension to heart failure
PTDC/DTP-FTO/0802/2012
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Unidade Multidisciplinar de Investigação Biomédica, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2014/12/31 Projecto Estratégico - UI 51 - 2011/ Strategic Project - UI 51 - 2011 (PEst-C/SAU/UI0051/2011)
PEst-C/SAU/UI0051/2011
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2010/06/01 - 2014/01/31 Role of the neuregulin system in pulmonary arterial hypertension - pathophysiological and therapeutic implications
100442
Provided by PTCRIS: 100442
Principal investigator
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/08 - 2010/11 New neurohumoral pathways in Pulmonary Arterial Hypertension - Pathophysiologic and therapeutic implications
65793
Provided by PTCRIS: 65793
PTDC/SAU-FCF/65793/2006
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/07 - 2008/06 Modulation of Myocardial Gene Expression by Acute and Chronic Cardiac Overload
POCTI/CBO/47519/2002
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2005/07 - 2008/06 Modulation of myocardial diastolic properties by endothelin-1 and angiotensin II - Pathophysiologic and therapeutic implications in heart failure
grant.Provided by PTCRIS: 60803
/SAU-FCT/60803/2004
Provided by PTCRIS: 60803
60803
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia

Universidade de Coimbra
Concluded
1998/07/01 - 2002/06/30 Pathophysiology of heart failure. From the animal model to clinical practice
PRAXIS/P/SAU/11301/1998
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
1996/12/01 - 2000/06/30 Study of neurohumoral and endothelial mechanisms in heart failure
2/2.1/SAU/1386/95-PRAXIS XXI
2/2.1/SAU/1386/95-PRAXIS XXI
Researcher
Universidade do Porto Faculdade de Medicina, Portugal
 Fundação para a Ciência e a Tecnologia

Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Inês Vasconcelos; Francisco Pérez-Vizcaíno; Adelino Leite-Moreira; Carmen Brás-Silva; Rui Adão. "Glycolysis in pulmonary arterial hypertension and metabolic reprogramming". 2024.
    10.1016/b978-0-323-91704-9.00008-2
  2. Brás-Silva, Carmen. "Cardiotoxicity of Cancer Chemotherapy–Recent Developments". In Frontiers in Drug Design & Discovery, edited by Rui Adao; Carolina Maia-Rocha; Diana Santos-Ribeiro; Pedro Mendes- Ferreira; Adelino Leite-Moreira; Carmen Bras-Silva, 36-83. Bentham Science Publishers Ltd., 2016.
    Published • 10.2174/9781681081656116070004
  3. Brás-Silva, Carmen. "Brás-Silva C, Neves D. Chapter 6- Cardiovascular Ageing. In: Anti-ageing Nutrients - Evidence-based Prevention of Age-related Diseases.Wiley-Blackwell. 2015". 2015.
    10.1002/9781118823408.ch6
  4. Carmen Brás Silva. "Capítulo 15 -Fisiopatologia dos Fluídos nos Compartimentos Corporais / "Chapter 15 - Pathophysiology of Body Fluid Compatments"". In Fisiopatologia. Fundamentos e Aplicações. Portugal, 2013.
    Published
  5. Carmen Brás-Silva. "Capítulo 27 - Fisiopatologia da Fome e da Saciedade /" Chapter 27 - Pathophysiology of Hunger and Satiety"". In Fisiopatologia. Fundamentos e Aplicações. Portugal, 2013.
    Published
  6. Brás-Silva, Carmen. "Fisiopatologia da Fome e da Saciedade / "Pathophysiology of Hunger and Satiety"". In Fisiopatologia. Fundamentos e Aplicações, 475-484. 2007.
    Published
  7. Brás-Silva, Carmen. "Fisiopatologia dos Fluídos nos Compartimentos Corporais "Pathophysiology of Body Fluid Compatments"". In Fisiopatologia. Fundamentos e Aplicações, 245-250. Lidel, 2007.
    Published
Conference abstract
  1. Bras-Silva, C. Corresponding author: Bras-Silva, C. "Does Urocortin-2 induce changes in neurogenesis and in the GABAergic system of the hippocampal formation of rats with heart failure with preserved ejection fraction?". Paper presented in 16th International and 58th Polish Conference Juvenes Promedicina 2020, 2020.
    Published
  2. Miranda, Sónia; Mendes-Ferreira, Pedro; Adão, Rui; Maia-Rocha, Carolina; Santos-Ribeiro, Diana; Pimentel, Luís; Monteiro-Pinto, Cláudia; et al. "MicroRNA-146a role in the pathophysiology of Pulmonary Arterial Hypertension". Paper presented in SPCCTV Congress, 2019.
    Published
  3. Mendes-Ferreira, Pedro; Adão, Rui; Leite-Moreira, Adelino; Brás-Silva, Carmen; Belge, Catharina. "ß-3 adrenoceptors: a therapeutic target for Pulmonary Arterial Hypertension". Paper presented in SPCCTV Congress, 2019.
    Published
  4. Adão, Rui; Kraler, Simon C; Holzer, Senka; Leite-Moreira, Adelino; Sedej, Simon; Brás-Silva, Carmen; ADELINO LEITE-MOREIRA. "Adão R, Mendes-Ferreira P, Hamdani N, Maia-Rocha C, Mendes MJ, Falcão-Pires I, De Keulenaer GW, Linke W, Leite-Moreira AF, Brás-Silva C. Neuregulin-1 preserves right ventricular diastolic function in animal model of pulmonary arterial hypertension. European Heart Journal". 2014.
  5. Falcao Pires, I; Fontes Sousa, AP; Lopes Conceicao, L; Bras Silva, C; Leite Moreira, AF; Pires, Falcão; Sousa, Adelino Fontes de; et al. "Modulation of myocardial stiffness by beta-adrenergic stimulation on rabbit papillary muscles-its role in normal and failing heart". 2010.
  6. Fontes Sousa, AP; Bras Silva, C; Monteiro Cardoso, V; Pereira Goncalves, N; Lopes Conceicao, L; Leite Moreira, AF. "Alpha-Adrenergic Stimulation Increases Myocardial Distensibility Through PKC Activation in Health and Disease". 2009.
  7. Bras Silva, C; Monteiro Sousa, D; Duarte, AJ; Leite Moreira, AF. "Functional evidence for the existence of ETA-ETB receptor crosstalk in the heart". 2007.
    10.1016/s1567-4215(07)60406-8
  8. Bras Silva, C; Duarte, AJ; Monteiro Sousa, D; Fontes Sousa, AP; Leite Moreira, AF. "Endothelin-1 increases myocardial distensibility through nitric oxide and prostaglandins release". 2006.
  9. Bras Silva, C; Leite Moreira, AF; Brás-Silva, C.; Leite-Moreira, A.F.; Brás-Silva C; Leite-Moreira AF. "Obligatory role of the endocardial endothelium in the increase of myocardial distensibility induced by endothelin-1". 2005.
  10. Falcao Pires, I; Vasconcelos, M; Magalhaes, J; Bras Silva, C; Leite Moreira, A. "Distinct contractile effects of apelin in intact hearts and isolated papillary muscles". 2005.
  11. Bras Silva, C; Leite Moreira, AF. "Functional evidence for the existence of two subtypes of ETB receptors in the heart". 2004.
  12. Bras Silva, C; Pedrosa, CA; Leite Moreira, AF. "Myocardial effects of selective ETB receptor stimulation are modulated by ETA receptor activity". 2003.
    10.1016/s0195-668x(03)95027-5
  13. Leite Moreira, AF; Bras Silva, C; Pedrosa, CA. "Inotropic effects of selective ET-B receptor stimulation and its modulation by endocardial endothelium, NO, and prostaglandins". 2002.
Conference paper
  1. Adão, Rui; Bras-Silva, C. Corresponding author: Bras-Silva, C. "Adão R, Conceição G, Miranda Silva D, Miranda S, Pimentel LD, Vaz Salvador P, Maia Rocha C, Mendes Ferreira P, Lourenço AP, Falcão Pires I, Leite-Moreira A, Brás Silva C. Role of urocortin-2 in heart failure with preserved ejection fraction. Rev Port Cardiol. 2020;39(Espec Congr): 23.". Paper presented in CPC 2021- Congresso Português de Cardiologia 2020 /Portuguese Congress of Cardiology 2020, 2020.
  2. Bras-Silva, C; Adão, Rui. Corresponding author: Bras-Silva, C. "Vaz-Salvador P, Adão R, Conceição G, Miranda-Silva D, Miranda S, Pimentel D, Maia-Rocha C, Mendes-Ferreira P, Lourenço AP, Falcão-Pires I, Leite-Moreira AF, Brás-Silva C. The role of Urocortin-2 in Heart Failure with Preserved Ejection Fraction. Porto Biomed J. 2021; 6:1:36.". Paper presented in Yes Meeting 2020, 2020.
  3. PINTALHÃO, MARIANA; Maia-Rocha C; Martins clara Rafael (3016-B135-BDE3); Adão, Rui; António barros; ADELINO LEITE-MOREIRA; Paulo Bettencourt; Paulo Castro Chaves; Brás-Silva, Carmen. "Serum Urocortin-2 is Associated With Volume Overload and Pulmonary Hypertension in Acute Heart Failure". Paper presented in AHA Scientific Sessions 2018, Chicago, 2018.
    Published
  4. Adão, Rui; Kraler, Simon C; Holzer, Senka; Leite-Moreira, Adelino; Sedej, Simon; Brás-Silva, Carmen. "Effects of urocortin-2 on cellular Ca2+ homeostasis in right heart failure induced by pulmonary artery hypertension". Paper presented in 28th International Congress of the European-Respiratory-Society (ERS), Paris, 2018.
    Published • 10.1183/13993003.congress-2018.oa1634
  5. Mendes Ferreira, Pedro; Adao, Rui; Quarck, Rozenn; Belge, Catharina; Delcroix, Marion; Bras-Silva, Carmen. "Activation of the Beta-3 adrenoceptor in experimental pulmonary hypertension". Paper presented in 28th International Congress of the European-Respiratory-Society (ERS), Paris, 2018.
    Published • 10.1183/13993003.congress-2018.pa3063
  6. Wambura, Jane; Brás-Silva, Carmen; Oliveira, B.M.P.M.; Correia, Flora. "Malnutrition among HIV exposed uninfected infants 24 months and below: a case of Mukuru Slum in Nairobi, Kenya". 2017.
  7. Maia-Rocha, Carolina; Rui Adão (E11C-E68E-8232); Pedro Mendes Ferreira (091B-9DCD-698D); Diana Santos Ribeiro (2C1B-09C1-2483); Miriam Rademaker; ADELINO F. LEITE-MOREIRA; Brás-Silva, Carmen. "The right ventricle molecular changes associated with pulmonary arterial hypertension are attenuated by Urocortin 2 treatment". Paper presented in Congress of the European-Society-of-Cardiology (ESC), Rome, 2016.
    Published
  8. Brás-Silva, Carmen. "Urocortin-2 attenuates right ventricular dysfunction in pulmonary arterial hypertension". Paper presented in Heart Failure 2016 Conference, 2016.
    Published
  9. Carolina Maia-Rocha; Rui Adão (E11C-E68E-8232); Pedro Mendes Ferreira (091B-9DCD-698D); Diana Santos Ribeiro (2C1B-09C1-2483); Miriam Rademaker; ADELINO F. LEITE-MOREIRA; Brás-Silva, Carmen. "The right ventricle molecular changes associated with pulmonary arterial hypertension are attenuated by Urocortin-2 treatment". Paper presented in Heart Failure 2016 Conference, 2016.
    Submitted
  10. Pedro Mendes Ferreira (091B-9DCD-698D); Diana Santos Ribeiro (2C1B-09C1-2483); Rui Adão (E11C-E68E-8232); Carolina Maia-Rocha; Miguel Mendes-Ferreira; Cláudia Sousa Mendes; ADELINO F. LEITE-MOREIRA; Brás-Silva, Carmen. "Pulmonary artery banding-induced adaptive and maladaptive remodelling of the right ventricle in the rat". Paper presented in Heart Failure 2016 Conference, 2016.
    Published
  11. Pedro Mendes Ferreira (091B-9DCD-698D); Frédéric Potus; Diana Santos Ribeiro (2C1B-09C1-2483); Carolina Maia-Rocha; Rui Adão (E11C-E68E-8232); ADELINO F. LEITE-MOREIRA; Steeve Provencher; Bonnet, Sébastien; Brás-Silva, Carmen. "MicroRNA-146a Expression Is Increased In Human PAH". Paper presented in International Conference of the American-Thoracic-Society (ATS), San Francisco, 2016.
    Published
  12. R Adao; P Mendes-Ferreira; N Hamdani; C Maia-Rocha; MJ Mendes; I Falcao-Pires; GW De Keulenaer; et al. "P505Neuregulin-1 ameliorates right ventricular diastolic dysfunction in pulmonary arterial hypertension". 2014.
    Published • 10.1093/cvr/cvu091.178
  13. Maia-Rocha, C.; Santos-Ribeiro, D.; Mendes-Ferreira, P.; Adão, R.; Alves, B.S.; De Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "Molecular mechanisms underlying the beneficial effects of neuregulin-1 in pulmonary arterial hypertension". 2014.
  14. Mendes-Ferreira, P.; Ribeiro, D.; Alves, B.; Adão, R.; Maia-Rocha, C.; de Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "Reversão da hipertrofia ventricular direita pela neuregulina-1". 2014.
  15. Maia-Rocha, C.; Mendes-Ferreira, P.; Adao, R.; Santos-Ribeiro, D.; Alves, B.S.; De Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "The right ventricle molecular changes associated with pulmonary arterial hypertension are attenuated by neuregulin-1 treatment". 2014.
  16. Adão, R.; Alves, B.S.; Santos-Ribeiro, D.; Mendes-Ferreira, P.; Maia-Rocha, C.; Hamdani, N.; Mendes, M.J.; et al. "Neuregulin-1 preserves right ventricular diastolic function in animal model of pulmonary arterial hypertension". 2014.
  17. Adao, R.; Mendes-Ferreira, P.; Hamdani, N.; Maia-Rocha, C.; Mendes, M.J.; Falcao-Pires, I.; De Keulenaer, G.W.; et al. "Neuregulin-1 preserves right ventricular diastolic function in animal model of pulmonary arterial hypertension". 2014.
  18. Adao, R.; Mendes-Ferreira, P.; Maia-Rocha, C.; Alves, B.S.; Santos-Ribeiro, D.; Falcao-Pires, I.; De Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "Neuregulina-1 modula a função dos cardiomiócitos do ventrículo direito na hipertensão arterial pulmonar". 2014.
  19. Santos-Ribeiro, D.; Alves, B.S.; Adão, R.; Maia-Rocha, C.; Mendes-Ferreira, P.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "Urocortin-2 improves right ventricular function in pulmonar arterial hypertension". 2014.
  20. Mendonca, L.L.; Mendes-Ferreira, P.; Leite, A.; Pintalhao, M.; Amorim, M.J.; Pinho, P.; Brás-Silva, Carmen; , et al.. "Angiotensin-(1-7) modulates Angiotensin II vasoconstrictor effect in human mammary artery". 2014.
  21. Adao, R.; Mendes-Ferreira, P.; Hamdani, N.; Maia-Rocha, C.; Mendes, M.J.; Falcao-Pires, I.; de Keulenaer, G.W.; et al. "Neuregulin-1 ameliorates right ventricular diastolic dysfunction in pulmonary arterial hypertension". Paper presented in 28th International Congress of the European-Respiratory-Society (ERS), Paris, 2014.
    Published • 10.1093/cvr/cvu098.174
  22. Santos-Ribeiro, D.; Adão, R.; Maia-Rocha, C.; Alves, B.; Mendes-Ferreira, P.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "Urocortin-2 Improves Right Ventricular Function In Pulmonary Arterial Hypertension". 2014.
  23. Alves, B.S; Santos-Ribeiro, D.; Adão, R.; Maia-Rocha, C.; Mendes-Ferreira, P.; Leite-Moreira, A.; Brás-Silva, Carmen. "Modulation of right ventricle function by Neuregulin-1 therapeutic implications in pulmonary hypertension". 2014.
  24. Alves, B.S.; Santos-Ribeiro, D.; Adão, R.; Maia-Rocha, C.; Mendes-Ferreira, P.; de Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "Right ventricle pressure overload-induced hypertrophy is attenuated by neuregulin-1". 2014.
  25. Maia-Rocha, C.; Mendes-Ferreira, P.; Adão, R.; Ribeiro, D.; Alves, B.; de Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "Mecanismos moleculares subjacentes aos efeitos benéficos da neuregulina-1 no tratamento da hipertensão arterial pulmonar". 2014.
  26. Mendes-Ferreira, P.; Santos-Ribeiro, D.; Alves, B.S.; Adao, R.; Maia-Rocha, C.; Leite-Moreira, A.F.; De Keulenaer, G.W.; Brás-Silva, Carmen. "Neuregulin-1 attenuates right ventricle hypertrophy in a model of pulmonary artery banding". 2014.
  27. Adão, R.; Alves, B.S.; Santos-Ribeiro, D.; Mendes-Ferreira, P.; Maia-Rocha, C.; Hamdani, N.; Mendes, M.J.; et al. "Neuregulin-1 preserves right ventricular diastolic function in animal model of pulmonary arterial hypertension". 2014.
  28. Mendonça, Luís; Leite, Ana; Chaves, Paulo; Ferreira, Pedro; Silva, Carmen Brás; Moreira, Adelino Leite. "Vascular effect of angiotensin 1-7 in the response to angiotensin II in internal thoracic arteries from patients undergoing coronary artery bypass grafting". 2013.
  29. Adão, Rui; Ferreira, Pedro; Rocha, Carolina; Lourenco, Andre; Pires, Inês; Keulenaer, Gilles; Moreira, Adelino; Silva, Carmen Brás. "Neuregulin-1 chronic treatment improves right ventricle cardiomyocyte function in pulmonary hypertension". 2013.
  30. Ferreira, Pedro; Adão, Rui; Rocha, Carolina; Lourenco, André; Meireles, André; Pires, Inês; Keulenaer, G.; Moreira, Adelino; Silva, Carmen Brás. "Neuregulin-1 treatment reduces right ventricular dysfunction in pulmonary arterial hypertension". 2013.
  31. Ferreira, Pedro; Adão, Rui; Rocha, Carolina; Cerqueira, Rui; Pires, Inês; Chaves, Paulo; Keulenaer, Gilles; Moreira, Adelino; Silva, Carmen Brás. "Efeitos terapêuticos da neuregulina-1 num modelo experimental de hipertensão pulmonar". 2013.
  32. Maia-Rocha, C.; Adão, R.; Mendes-Ferreira, P.; Mendes, M.J.; Pinho, S.; Lourenço, A.P.; De Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "Neuregulin attenuates right ventricular hypertrophy and dysfunction in an experimental model of pulmonary hypertension". 2012.
  33. Mendes-Ferreira, P.; Adão, R.; Cerqueira, R.J.; Maia-Rocha, C.; Mendes, M.J.; Castro-Chaves, P.; De Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, Carmen. "A neuregulina-1 atenua a disfunção endotelial na hipertensão arterial pulmonar". 2012.
  34. Mendes-Ferreira, P.; Maia-Rocha, C.; Adão, R.; Lourenço, A.P.; Cerqueira, R.; Mendes, M.J.; Castro-Chaves, P.; et al. "Neuregulin attenuates right ventricular hypertrophy and dysfunction in an experimental model of pulmonary hypertension". 2012.
  35. Mendes-Ferreira, P.; Maia-Rocha, C.; Adão, R.; Lourenço, A.P.; Moura, C.; Mendes,M.J.; Pinho, S.; et al. "A neuregulina atenua a hipertrofia e a disfunção ventricular direitas num modelo experimental de hipertensão pulmonar". 2012.
  36. Mendes-Ferreira, P.; Maia-Rocha, C.; Adao, R.; Cerqueira, R.J.; Mendes, M.J.; Lourenco, A.P.; Pinho, S.; et al. "NRG-1 improves monocrotaline-induced right ventricular and pulmonary endothelial dysfunction". 2012.
  37. Rocha, C. Maia; Ferreira, P. Mendes; Adão, R.; Silva, M.; Lourenço, A.; Leite-Moreira, Adelino; Brás-Silva, Carmen. "Neuregulin increased expression and its modulation by bosentan in pulmonary hypertension". 2011.
  38. Brás-Silva, Carmen; Rocha, C. Maia; Ferreira, P. Mendes; Adão, R.; Lourenço, A.; Leite-Moreira, Adelino. "Aumento da expressão génica de neuregulina e sua modulação pelo bosentan na hipertensão pulmonar". 2011.
  39. Guerra, Miguel; Amorim, Mário; Brás-Silva, Carmen; Bastos, Pedro; Leite-Moreira, Adelino. "Intraventricular pressure gradients along the cardiac cycle: effects of ischemia and modulation by afterload". 2011.
  40. Ferreira, P. Mendes; Rocha, C. Maia; Adão, R.; Silva, M.; Mendes, M.; Lourenço, A.; Cerqueira, R.; et al. "Neuregulin attenuates right ventricular hypertrophy and dysfunction in an experimental model of pulmonary hypertension". 2011.
  41. Silva, Carmen Brás; Sousa, A. Fontes de; Silva, S.; Gomes, M.; Ferreira, P.; Moreira, A. Leite; Bras Silva, C; et al. "The acute effects of urocortin 2 on the diastolic properties of the myocardium". 2010.
  42. Silva, S.; Gomes, M.; Ferreira, P. Mendes; Sousa, P. Fontes; Moreira, Adelino Leite; Silva, Carmen Brás. "A urocortina2 induz efeitos agudos sobre a rigidez diastólica". 2010.
  43. Martins, Margarida; Brás-Silva, Carmen. "Efeito da sobrecarga ponderal em indivíduos com enxaqueca". 2009.
  44. Sousa, Ana Fontes de; Conceição, Luísa; Cardoso, Vera; Gonçalves, Nádia; Silva, Carmen Brás; Moreira, Adelino Leite. "A diminuição da rigidez miocárdica induzida pela fenilefrina é modulada pela PKC". 2009.
  45. Martins, Margarida; Silva, Carmen Brás. "Eficácia da suplementação nutricional no tratamento profiláctico da enxaqueca". 2009.
  46. Silva, Sónia; Simões, Inês; Ferreira, Pedro; Gomes, Marques; Moreira, Adelino Leite; Silva, Carmen Brás. "Urocortin 2 Acutely Decreases Diastolic Stiffness". 2009.
  47. Nóvoa, Francisco Vasques; Lourenço, André; Silva, Carmen Brás; Silva, Daniela; Pinto Duarte; Moreira, Adelino Leite; Albuquerque Jr, Robert Roncon. "A dieta do tipo ocidental atenua a hipertensão pulmonar e a remodelagem miocárdica num modelo experimental de hipertensão pulmonar". 2009.
  48. Silva, Carmen Brás; Almeida, Mónica; Mendes, Susana; Sousa, Ana Fontes de; Moreira, Adelino Leite. "O aumento da distensibilidade miocárdica induzido pela Urocortina 2 é dependente das cínases das proteínas A e C". 2009.
  49. Sousa, Ana Fontes de; Conceição, Luísa Lopes; Silva, Carmen Brás; Moreira, Adelino Leite. "Alpha1-adrenergic stimulation decreases myocardial stiffness: a novel PKC mediated effect". 2009.
  50. Oliveira, Margarida; Silva, Carmen Brás. "Factores alimentares e nutricionais implicados na fisiopatologia da enxaqueca". 2009.
  51. Silva, Carmen Brás; Sousa, Ana Fontes de; Mendes, Susana; Almeida, Mónica; Moreira, Adelino Leite. "The urocortin 2-induced decrease in myocardial stiffness is compromised in heart failure.". 2008.
  52. Moreira, Adelino Leite; Silva, Carmen Brás; Carneiro, C.S.; Gonçalves, Nádia Pereira; Monteiro, V. Cardoso; Sousa, Ana Fontes de. "Alpha-adrenergic system as a novel regulatory system of myocardial stiffness in health and disease.". 2008.
  53. Silva, Carmen Brás; Sousa, Ana Fontes de; Almeida, Mónica; Mendes, Susana; Moreira, Adelino Leite. "The urocortin 2-induced decrease in myocardial stiffness is compromised in heart failure.". 2008.
  54. Moreira, Adelino Leite; Silva, Carmen Brás; Almeida, Mónica; Mendes, Susana; Sousa, Ana Fontes de. "Modulation of Urocortin 2 Contractile Effects by Endocardial Endothelium.". 2008.
  55. Silva, Carmen Brás; Sousa, Ana Fontes de; Almeida, Mónica; Mendes, Susana; Moreira, Adelino Leite. "The urocortin 2-induced decrease in myocardial stiffness is compromised in heart failure.". 2008.
  56. Silva, Carmen Brás; Sousa, Ana Fontes de; Mendes, Susana; Almeida, Mónica; Moreira, Adelino Leite. "The urocortin 2-induced decrease in myocardial stiffness is compromised in heart failure.". 2008.
Conference poster
  1. Fontes-Sousa, Ana Patrícia; Lopes-Conceição, Luisa; Pereira-Gonçalves, Nádia; Monteiro-Cardoso, Vera; Brás-Silva, Carmen; Leite-Moreira, Adelino. "Alpha-adrenergic stimulation decreases myocardial stiffness: a novel PKC mediated-effect". Paper presented in European Society of Cardiology Congress, 2009.
  2. Martins-Oliveira, Margarida; Brás-Silva, Carmen. "Efficacy of nutritional supplementation in the prophylactic treatment of migraine.". Paper presented in Spring Meeting of the Portuguese Headache Society, Ponta Delgada, Açores, Portugal, 2009.
  3. Martins-Oliveira, Margarida; Brás-Silva, Carmen. "Effect of overweight in subjects with migraine.". Paper presented in Spring Meeting of the Portuguese Headache Society, Ponta Delgada, Açores, Portugal, 2009.
  4. Martins-Oliveira, Margarida; Brás-Silva, Carmen. "Dietary and nutritional factors involved in the pathophysiology of migraine.". Paper presented in Spring Meeting of the Portuguese Headache Society, Ponta Delgada, Açores, Portugal, 2009.
Journal article
  1. Gabriel Faria-Costa; João Oliveira; Inês Vilas-Boas; Inês Campelo; Elisa Azeredo Silva; Carmen Brás-Silva; Susana Maria Silva; Tiago Antunes-Lopes; Ana Charrua. "The Ketone Bridge Between the Heart and the Bladder: How Fast Should We Go?". International Neurourology Journal (2024): https://doi.org/10.5213/inj.2346250.125.
    10.5213/inj.2346250.125
  2. Bras-Silva, C. "Corticotropin-releasing hormone and obesity: From fetal life to adulthood.". Obesity Reviews (2024): https://doi.org/10.1111/obr.13763.
    In press • https://doi.org/10.1111/obr.13763
  3. André Balsa; Rui Adão; Carmen Brás-Silva. "Therapeutic Approaches in Pulmonary Arterial Hypertension with Beneficial Effects on Right Ventricular Function—Preclinical Studies". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms242115539.
    10.3390/ijms242115539
  4. Sousa MP; Bettencourt P; Brás-Silva C; Pereira C. "Biosensors for natriuretic peptides in cardiovascular diseases. A review.". Current problems in cardiology (2023): http://europepmc.org/abstract/med/37907188.
    10.1016/j.cpcardiol.2023.102180
  5. Almeida-Pinto N; Dschietzig TB; Brás-Silva C; Adão R. "Cardiovascular effects of relaxin-2: therapeutic potential and future perspectives.". Clinical research in cardiology : official journal of the German Cardiac Society (2023): http://europepmc.org/abstract/med/37721595.
    10.1007/s00392-023-02305-1
  6. Saint-Martin Willer A; Santos-Gomes J; Adão R; Brás-Silva C; Eyries M; Pérez-Vizcaino F; Capuano V; Montani D; Antigny F. "Physiological and pathophysiological roles of the KCNK3 potassium channel in the pulmonary circulation and the heart.". The Journal of physiology (2023): http://europepmc.org/abstract/med/37477289.
    10.1113/jp284936
  7. Mulvaney EP; Renzo F; Adão R; Dupre E; Bialesova L; Salvatore V; Reid HM; et al. "The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload.". Frontiers in cardiovascular medicine (2022): http://europepmc.org/abstract/med/36588576.
    10.3389/fcvm.2022.1063967
  8. Bras-Silva C; Rita Figueiredo; Rui Adão; Adelino F. Leite-Moreira; Jennifer Mâncio; Carmen Brás-Silva. "Candidate microRNAs as prognostic biomarkers in heart failure: A systematic review". Revista Portuguesa de Cardiologia 41 10 (2022): 865-885. http://dx.doi.org/10.1016/j.repc.2021.03.020.
    10.1016/j.repc.2021.03.020
  9. Ana Reis-Ferreira; Joana Neto-Mendes; Carmen Brás-Silva; Luís Lobo; Ana Patrícia Fontes-Sousa. "Emerging Roles of Micrornas in Veterinary Cardiology". Veterinary Sciences (2022): https://doi.org/10.3390/vetsci9100533.
    10.3390/vetsci9100533
  10. Bras-Silva C; Joana Santos-Gomes; Inês Gandra; Rui Adão; Frédéric Perros; Carmen Brás-Silva; Santos-Gomes, Joana; et al. "An Overview of Circulating Pulmonary Arterial Hypertension Biomarkers". Frontiers in Cardiovascular Medicine 9 (2022): http://dx.doi.org/10.3389/fcvm.2022.924873.
    10.3389/fcvm.2022.924873
  11. Bras-Silva C; Rúben Almeida-Pinto; Adelino F. Leite-Moreira; Carmen Brás-Silva; Adão R. "Pulmonary Valve Replacement: A New Paradigm with Tissue Engineering". Current Problems in Cardiology (2022): 101212-101212. http://dx.doi.org/10.1016/j.cpcardiol.2022.101212.
    10.1016/j.cpcardiol.2022.101212
  12. Joana Santos-Gomes; Hélène Le Ribeuz; Carmen Brás-Silva; Fabrice Antigny; Rui Adão. "Role of Ion Channel Remodeling in Endothelial Dysfunction Induced by Pulmonary Arterial Hypertension". Biomolecules 12 4 (2022): 484-484. https://doi.org/10.3390/biom12040484.
    10.3390/biom12040484
  13. Vaz-Salvador, Pedro; Adão, Rui; Vasconcelos, Inês; Leite-Moreira, Adelino F.; Brás-Silva, Carmen. "Heart Failure with Preserved Ejection Fraction: a Pharmacotherapeutic Update". Cardiovascular Drugs and Therapy (2022): http://dx.doi.org/10.1007/s10557-021-07306-8.
    Published • 10.1007/s10557-021-07306-8
  14. Inês Vasconcelos; Rui Adão; Miriam T. Rademaker; Adelino F. Leite-Moreira; Ana Patrícia Fontes-Sousa; Carmen Brás-Silva; Vasconcelos, Inês; et al. "Urocortins as biomarkers in cardiovascular disease". Clinical Science 136 1 (2022): 1-14. https://doi.org/10.1042/CS20210732.
    10.1042/CS20210732
  15. Pintalhao M; Maia-Rocha C; Castro-Chaves P; Adão R; Barros AS; Clara Martins R; Leite-Moreira A; Bettencourt P; Bras-Silva C. "Urocortin-2 in Acute Heart Failure: Role as a Marker of Volume Overload and Pulmonary Hypertension.". Current problems in cardiology (2021): http://europepmc.org/abstract/med/33994037.
    10.1016/j.cpcardiol.2021.100860
  16. Vaz-Salvador, Pedro; Adão, Rui; Conceição, Glória; Silva, Daniela; Miranda, Sónia; Pimentel, Luís; Rocha, Carolina; et al. "15th YES Meeting ¿ Abstracts". Porto Biomedical Journal 6 1 (2021): e100. http://dx.doi.org/10.1097/j.pbj.0000000000000100.
    Published • 10.1097/j.pbj.0000000000000100
  17. Lambert M; Mendes-Ferreira P; Ghigna MR; LeRibeuz H; Adão R; Boet A; Capuano V; et al. "Kcnk3 Dysfunction Exaggerates The Development Of Pulmonary Hypertension Induced By Left Ventricular Pressure Overload.". Cardiovascular research (2021): http://europepmc.org/abstract/med/33483721.
    10.1093/cvr/cvab016
  18. Mulvaney EP; Reid HM; Bialesova L; Mendes-Ferreira P; Adão R; Brás-Silva C; Kinsella BT; et al. "Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension.". European journal of pharmacology (2020): http://europepmc.org/abstract/med/33121950.
    Submitted • 10.1016/j.ejphar.2020.173658
  19. Martinho S; Adão R; Leite-Moreira AF; Brás-Silva C. "Persistent Pulmonary Hypertension of the Newborn: Pathophysiological Mechanisms and Novel Therapeutic Approaches.". Frontiers in pediatrics (2020): http://europepmc.org/abstract/med/32850518.
    10.3389/fped.2020.00342
  20. Mendes-Ferreira, Pedro; Adão, Rui; Miranda, Alice; Leite-Moreira, Adelino F.; Brás-Silva, Carmen. "Comprehensive cardiovascular function analysis in rodents with right heart failure". Journal of Visualized Experiments (2020):
    Under revision
  21. Monteiro-Pinto C; Adão R; Leite-Moreira AF; Brás-Silva C. "Cardiovascular Effects of Urocortin-2: Pathophysiological Mechanisms and Therapeutic Potential.". Cardiovascular drugs and therapy (2019): http://europepmc.org/abstract/med/31512017.
    10.1007/s10557-019-06895-9
  22. Pereira-Castro J; Brás-Silva C; Fontes-Sousa AP. "Novel insights into the role of urotensin II in cardiovascular disease.". Drug discovery today (2019): http://europepmc.org/abstract/med/31430542.
    10.1016/j.drudis.2019.08.005
  23. Adão, Rui; Kraler, Simon; Abdellatif, Mahmoud; Pinto, Ana Rita; Mendes-Ferreira, Pedro; Ljubojevic-Holzer, S; Leite-Moreira, Adelino; Sedej, Simon; Brás-Silva, Carmen. "Acute and chronic effects of urocortin-2 therapy on intracellular Ca2+ homeostasis in right heart failure induced by pulmonary arterial hypertension". Scientific Reports (2019):
    Under revision
  24. Hautefort A; Mendes-Ferreira P; Sabourin J; Manaud G; Bertero T; Rücker-Martin C; Riou M; et al. "Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension.". Circulation (2018): http://europepmc.org/abstract/med/30586714.
    10.1161/circulationaha.118.033744
  25. Adão R; Mendes-Ferreira P; Maia-Rocha C; Santos-Ribeiro D; Rodrigues PG; Vidal-Meireles A; Monteiro-Pinto C; et al. "Neuregulin-1 attenuates right ventricular diastolic stiffness in experimental pulmonary hypertension.". Clinical and experimental pharmacology & physiology (2018): http://europepmc.org/abstract/med/30339273.
    10.1111/1440-1681.13043
  26. Corremans R; Adão R; De Keulenaer GW; Leite-Moreira AF; Brás-Silva C. "Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity.". Clinical and experimental pharmacology & physiology (2018): http://europepmc.org/abstract/med/30244497.
    10.1111/1440-1681.13036
  27. Lambert M; Boet A; Rucker-Martin C; Mendes-Ferreira P; Capuano V; Hatem S; Adão R; et al. "Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension.". Cardiovascular research (2018): http://europepmc.org/abstract/med/29360952.
    10.1093/cvr/cvy016
  28. Guerra, Miguel; Mendes-Ferreira, Pedro; Adão, Rui; Pereira, Eulália; Vieira, Manuela; Lourenço, André P.; Brás-Silva, Carmen; et al. "Improvement in left intraventricular pressure gradients after aortic valve replacement in aortic stenosis patients". Experimental Physiology 102 4 (2017): 411-421. http://dx.doi.org/10.1113/ep086191.
    Published • 10.1113/ep086191
  29. Pedro Mendes-Ferreira; Diana Santos-Ribeiro; Rui Adão; Carolina Maia-Rocha; Miguel Mendes-Ferreira; Cláudia Sousa-Mendes; Adelino F. Leite-Moreira; Carmen Brás-Silva. "Distinct Right Ventricle Remodeling in response to pressure overload in the rat". Am J Physiol Heart Circ Physiol (2016): ajpheart.00089.2016-ajpheart.00089.2016. http://dx.doi.org/10.1152/ajpheart.00089.2016.
    10.1152/ajpheart.00089.2016
  30. Mendes-Ferreira P; Maia-Rocha C; Adão R; Mendes MJ; Santos-Ribeiro D; Alves BS; Cerqueira RJ; et al. "Neuregulin-1 improves right ventricular function and attenuates experimental pulmonary arterial hypertension.". (2016): http://europepmc.org/abstract/med/26503987.
    10.1093/cvr/cvv244
  31. Santos-Ribeiro, D.; Mendes-Ferreira, P.; Maia-Rocha, C.; Adão, R.; Leite-Moreira, A.F.; Brás-Silva, C.. "Pulmonary arterial hypertension: Basic knowledge for clinicians | Hypertension artérielle pulmonaire : connaissances de base pour les cliniciens". Archives of Cardiovascular Diseases 109 10 (2016): 550-561. http://www.scopus.com/inward/record.url?eid=2-s2.0-84994165256&partnerID=MN8TOARS.
    10.1016/j.acvd.2016.03.004
  32. Adão, R.; Santos-Ribeiro, D.; Rademaker, M.T.; Leite-Moreira, A.F.; Brás-Silva, C.. "Urocortin 2 in cardiovascular health and disease". Drug Discovery Today (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84924956181&partnerID=MN8TOARS.
    10.1016/j.drudis.2015.02.012
  33. Mendonça, L.; Mendes-Ferreira, P.; Bento-Leite, A.; Cerqueira, R.; Amorim, M.J.; Pinho, P.; Brás-Silva, C.; Leite-Moreira, A.F.; Castro-Chaves, P.. "Angiotensin-(1–7) Modulates Angiotensin II-Induced Vasoconstriction in Human Mammary Artery". Cardiovascular Drugs and Therapy 28 6 (2014): 513-522. http://www.scopus.com/inward/record.url?eid=2-s2.0-84916220685&partnerID=MN8TOARS.
    Published • 10.1007/s10557-014-6555-4
  34. Adão, R.; De Keulenaer, G.; Leite-Moreira, A.; Bras-Silva, C.. "Cardiotoxicity associated with cancer therapy: Pathophysiology and prevention strategies | Cardiotoxicidade associada à terapêutica oncológica: Mecanismos fisiopatológicos e estratégias de prevençã o". Revista Portuguesa de Cardiologia 32 5 (2013): 395-409. http://www.scopus.com/inward/record.url?eid=2-s2.0-84880142554&partnerID=MN8TOARS.
    Published • 10.1016/j.repc.2012.11.002
  35. Gomes, A.C.; Falcão-Pires, I.; Pires, A.L.; Brás-Silva, C.; Leite-Moreira, A.F.. "Rodent models of heart failure: An updated review". Heart Failure Reviews 18 2 (2013): 219-249. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879464622&partnerID=MN8TOARS.
    Published • 10.1007/s10741-012-9305-3
  36. Mendes-Ferreira, P.; De Keulenaer, G.W.; Leite-Moreira, A.F.; Brás-Silva, C.. "Therapeutic potential of neuregulin-1 in cardiovascular disease". Drug Discovery Today 18 17-18 (2013): 836-842. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883242344&partnerID=MN8TOARS.
    Published • 10.1016/j.drudis.2013.01.010
  37. Guerra, M.; Amorim, M.J.; Brás-Silva, C.; Leite-Moreira, A.F.. "Intraventricular pressure gradients throughout the cardiac cycle: Effects of ischaemia and modulation by afterload". Experimental Physiology 98 1 (2013): 149-160. http://www.scopus.com/inward/record.url?eid=2-s2.0-84872173087&partnerID=MN8TOARS.
    10.1113/expphysiol.2012.066324
  38. Guerra, M.; Brás-Silva, C.; Amorim, M.J.; Moura, C.; Bastos, P.; Leite-Moreira, A.F.. "Intraventricular pressure gradients in heart failure". Physiological Research 62 5 (2013): 479-487. http://www.scopus.com/inward/record.url?eid=2-s2.0-84888807833&partnerID=MN8TOARS.
  39. Lopes-Conceição L; Dias-Neto M; Fontes-Sousa AP; Mendes-Ferreira P; Maia-Rocha C; Henriques-Coelho T; de Keulenaer G; Leite Moreira AF; Brás-Silva C. "[Neuregulin1/ErbB system: importance in the control of cardiovascular function].". Acta Médica Portuguesa 24 (2011): 1009-1020. http://europepmc.org/abstract/med/22863512.
    Published
  40. Falcao-Pires I; Fontes-Sousa AP; Lopes-Conceiçao L; Brás-Silva C; Leite-Moreira AF; Falcão-Pires, I.; Fontes-Sousa, A.P.; et al. "Modulation of myocardial stiffness by ß-adrenergic stimulation--its role in normal and failing heart.". Physiological research 60 4 (2011): 599-609. http://europepmc.org/abstract/med/21574754.
    Published
  41. Guerra, M.; Sampaio, F.; Brás-Silva, C.; Leite-Moreira, A.F.. "Left intraventricular diastolic and systolic pressure gradients". Experimental Biology and Medicine 236 12 (2011): 1364-1372. http://www.scopus.com/inward/record.url?eid=2-s2.0-82755177404&partnerID=MN8TOARS.
    10.1258/ebm.2011.011134
  42. Lopes-Conceição, L.; Dias-Neto, M.; Fontes-Sousa, A.P.; Mendes-Ferreira, P.; Maia-Rocha, C.; Henriquescoelho, T.; de Keulenaer, G.; Leite Moreira, A.F.; Brás-Silva, C.. "Neuregulin1/ErbB system: Importance in the control of cardiovascular function | Sistema neuregulina1/ErbB: Importância no controlo da função cardíaca". Acta Medica Portuguesa 24 SUPPL.4 (2011): 1009-1020. http://www.scopus.com/inward/record.url?eid=2-s2.0-84864244767&partnerID=MN8TOARS.
    Published
  43. Lourenço, A.P.; Vasques-Nóvoa, F.; Fontoura, D.; Brás-Silva, C.; Roncon-Albuquerque Jr., R.; Leite-Moreira, A.F.. "A western-type diet attenuates pulmonary hypertension with heart failure and cardiac cachexia in rats". Journal of Nutrition 141 11 (2011): 1954-1960. http://www.scopus.com/inward/record.url?eid=2-s2.0-81055149721&partnerID=MN8TOARS.
    10.3945/jn.111.145763
  44. Martins, Margarida; Silva, Carmen Brás. "Enxaqueca: fisiopatologia e factores alimentares desencadeantes". (2010): https://hdl.handle.net/10216/52619.
  45. Carreira, Helena; Amaral, Teresa F; Brás-Silva, Carmen; Oliveira, Bruno M P M; Borges, Nuno; Carreira H; Amaral TF; et al. "Hand grip strength in a sample of 11 to 14 years old children.". Acta medica portuguesa (2010): https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/722.
  46. Sousa M; Brás-Silva C; Leite-Moreira A. "[The role of leptin in the regulation of energy balance].". Acta medica portuguesa (2009): http://europepmc.org/abstract/med/19686630.
  47. Fontes-Sousa, A.P.; Pires, A.L.; Carneiro, C.S.; Brás-Silva, C.; Leite-Moreira, A.F.. "Effects of adrenomedullin on systolic and diastolic myocardial function". Peptides 30 4 (2009): 796-802. http://www.scopus.com/inward/record.url?eid=2-s2.0-62749178503&partnerID=MN8TOARS.
    10.1016/j.peptides.2008.12.011
  48. Silva, Carmen Brás. "Efeito da urocortina 2 na diminuição da rigidez miocárdica". (2009): https://hdl.handle.net/10216/96328.
  49. Sousa, Ana Fontes de; Silva, Carmen Brás; Cardoso, Vera Monteiro; Gonçalves, Nádia Pereira; Conceição, Luísa Lopes; Moreira, Adelino Leite. "Alpha-Adrenergic Stimulation Increases Myocardial Distensibility Through PKC Activation in Health and Disease". (2009): https://hdl.handle.net/10216/20515.
  50. Silva, Carmen Brás; Sousa, Ana Fontes de; Almeida, Mónica; Mendes, Susana; Moreira, Adelino Leite. "The Urocortin 2-Induced Increase in Myocardial Distensibility Is Compromised in Heart Failure". (2009): https://hdl.handle.net/10216/100665.
  51. Silva, Carmen Brás; Almeida, Mónica; Sousa, Ana Fontes de; Moreira, Adelino Leite. "Urocortin-2 induced decrease in myocardial stiffness - contribution of PKA and PKC". (2009): https://hdl.handle.net/10216/94716.
  52. Cerdeira, A.S.; Brás-Silva, C.; Leite-Moreira, A.F.. "Endothelin-converting enzyme inhibitors: Their application in cardiovascular diseases | Inibidores da enzima de conversão da endotelina e sua aplicação na patologia cardiovascular". Revista Portuguesa de Cardiologia 27 3 (2008): 385-408. http://www.scopus.com/inward/record.url?eid=2-s2.0-43049105055&partnerID=MN8TOARS.
  53. Brás-Silva, C.; Leite-Moreira, A.F.. "Myocardial effects of endothelin-1 | Efeitos miocárdicos da endotelina-1". Revista Portuguesa de Cardiologia 27 7-8 (2008): 925-951. http://www.scopus.com/inward/record.url?eid=2-s2.0-53549132501&partnerID=MN8TOARS.
    Published
  54. Lourenço, A.P.; Viterbo, J.F.; Silva, Carmen Brás; Vieira, F.; Moreira, Adelino Leite. "Acute haemodynamic effects of tezosentan in rats with monocrotaline-induced pulmonary hypertension.". (2008): https://repositorio-aberto.up.pt/handle/10216/100615.
  55. Silva, Carmen Brás; Sousa, Ana Fontes de; Almeida, Mónica; Mendes, Susana; Moreira, Adelino Leite. "Efeitos miocárdicos da Urocortina 2 na presença de insuficiência cardíaca.". (2008): https://hdl.handle.net/10216/94849.
  56. Sousa, Ana Fontes de; Silva, Carmen Brás; Cardoso, Vera Monteiro; Gonçalves, Nádia Pereira; Pires, Inês Falcao; Moreira, Adelino Leite. "Sistema alfa-adrenérgico, um importante modulador da rigidez miocárdica em corações normais e insuficientes.". (2008): https://repositorio-aberto.up.pt/handle/10216/99193.
  57. Silva, Carmen Brás; Sousa, Ana Fontes de; Mendes, Susana; Almeida, Mónica; Moreira, Adelino Leite. "The inotropic and lusitropic responses to urocortin 2 are increased in the presence of endocardial endothelial dysfunction.". (2008): https://repositorio-aberto.up.pt/handle/10216/94313.
  58. Moreira, Adelino Leite; Silva, Carmen Brás. "Modulação neuro-humoral da função diastólica - estado da ciência.". (2008): https://hdl.handle.net/10216/96408.
  59. Sousa, Ana Fontes de; Silva, Carmen Brás; Cardoso, Vera Monteiro; Gonçalves, Nádia Pereira; Pires, Inês Falcao; Moreira, Adelino Leite; Fontes Sousa, AP; et al. "Alfa-Adrenergic system: Important regulatory system of myocardial stiffness.". (2008): https://hdl.handle.net/10216/92992.
  60. Silva, Carmen Brás; Sousa, Ana Fontes de; Almeida, Mónica; Mendes, Susana; Moreira, Adelino Leite. "Increased inotropic and lusitropic responses to urocortin 2 in the presence of endocardial endothelial dysfunction.". (2008): https://hdl.handle.net/10216/100040.
  61. Silva, Carmen Brás; Moreira, Adelino Leite. "Efeitos Miocárdicos da Endotelina-1". (2008): https://hdl.handle.net/10216/10786.
  62. Brás-Silva C; Monteiro-Sousa D; Duarte AJ; Guerra M; Fontes-Sousa AP; Moura C; Areias JC; et al. "Nitric oxide and prostaglandins - important players in endothelin-1 induced myocardial distensibility.". Physiological research 57 2 (2007): 165-174. http://europepmc.org/abstract/med/17552879.
    Published
  63. Fontes-Sousa, A.P.; Brás-Silva, C.; Pires, A.L.; Monteiro-Sousa, D.; Leite-Moreira, A.F.. "Urotensin II acutely increases myocardial length and distensibility: Potential implications for diastolic function and ventricular remodeling". Naunyn-Schmiedeberg's Archives of Pharmacology 376 1-2 (2007): 107-115. http://www.scopus.com/inward/record.url?eid=2-s2.0-38449119600&partnerID=MN8TOARS.
    10.1007/s00210-007-0180-8
  64. Falcao-Pires, Ines; Fontes-Sousa, Ana P.; Bras-Silva, Carmen; Leite-Moreira, Adelino. "beta-adrenergic stimulation acutely increases myocardial distensibility - A PKA, PKC and Na+/H+ exchanger mediated effect". Journal of the American College of Cardiology 49 9 (2007): 408A-408A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000244651802562&KeyUID=WOS:000244651802562.
  65. Ferreira-Martins, J.; Pires, A. L.; Ladeiras-Lopes, R.; Bras-Silva, C.; Monteiro-Sousa, D.; Castro-Chaves, P.; Leite-Moreira, A.. "Acute muscle stretch induces a time-dependent decrease in myocardial stiffness that is partially mediated by PKC activation". European Heart Journal 28 (2007): 426-426. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000208702202259&KeyUID=WOS:000208702202259.
  66. Bras-Silva, C.; Monteiro-Sousa, D.; Duarte, A.; Leite-Moreira, A.; Duarte, A. J.; Leite-Moreira, A. F.. "Functional evidence for the existence of ETA-ETB receptor crosstalk in the heart". Journal of Hypertension 25 (2007): S60-S60. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248395100205&KeyUID=WOS:000248395100205.
  67. Fontes-Sousa, A. P.; Falcao-Pires, I.; Bras-Silva, C.; Leite-Moreira, A. F.. "The acute decrease of myocardial stiffness induced by beta-adrenergic stimulation is independent of the endocardial endothelium and prostaglandins release". European Journal of Heart Failure 6 (2007): 38-38. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000247726500108&KeyUID=WOS:000247726500108.
    10.1016/S1567-4215(07)60105-2
  68. Falcao-Pires, I.; Fontes-Sousa, A. P.; Bras-Silva, C.; Leite-Moreira, A. F.. "The acute decrease of myocardial stiffness induced by B-adrenergic stimulation is independent of the endocardial endothelium and prostaglandins release". Journal of Hypertension 25 (2007): S181-S181. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248395100633&KeyUID=WOS:000248395100633.
  69. Martins, J.; Pires, A. L.; Ladeiras-Lopes, R.; Monteiro-Sousa, D.; Bras-Silva, C.; Leite-Moreira, A.. "Time dependent increase in myocardial distensibility after an acute preload elevation". European Journal of Heart Failure 6 (2007): 9-9. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000247726500023&KeyUID=WOS:000247726500023.
    10.1016/S1567-4215(07)60020-4
  70. Ferreira-Martins, J.; Pires, A. Luisa; Ladeiras-Lopes, R.; Bras-Silva, C.; Monteiro-Sousa, D.; Castro-Chaves, P.; Leite-Moreira, A.. "Time dependent increase in myocardial distensibility after acute muscle stretch: The diastolic side of the Anrep effect". Journal of Hypertension 25 (2007): S310-S310. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000248395101378&KeyUID=WOS:000248395101378.
  71. Bras-Silva, C.; Monteiro-Sousa, D.; Duarte, A. J.; Lete-Moreira, A. F.. "Urocortin 2 as a novel neurohumoral modulator of diastolic function". European Heart Journal 28 (2007): 304-304. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000208702201429&KeyUID=WOS:000208702201429.
  72. Bras-Silva, C.; Duarte, A. J.; Monteiro-Sousa, D.; Leite-Moreira, A. F.; Bras-Silva, Carmen; Monteiro-Sousa, Daniela; Duarte, Ana Joana; Leite-Moreira, Adelino F.. "Urocortin 2 acutely decreases myocardial stiffness". European Journal of Heart Failure 6 16 (2007): 39-40. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000247726500113&KeyUID=WOS:000247726500113.
    10.1016/S1567-4215(07)60110-6
  73. Fontes-Sousa, Ana Patrícia N.; Brás-Silva, Carmen; Moura, Cláudia; Areias, José Carlos; Leite-Moreira, Adelino F.. "M-mode and Doppler echocardiographic reference values for male New Zealand white rabbits". American Journal of Veterinary Research 67 10 (2006): 1725-1729. http://dx.doi.org/10.2460/ajvr.67.10.1725.
    Published • 10.2460/ajvr.67.10.1725
  74. Lourenço, André P.; Roncon-Albuquerque, Roberto; Brás-Silva, Carmen; Faria, Bernardo; Wieland, Joris; Henriques-Coelho, Tiago; Correia-Pinto, Jorge; et al. "Myocardial dysfunction and neurohumoral activation without remodeling in left ventricle of monocrotaline-induced pulmonary hypertensive rats". American Journal of Physiology-Heart and Circulatory Physiology 291 4 (2006): H1587-H1594. http://dx.doi.org/10.1152/ajpheart.01004.2005.
    Published • 10.1152/ajpheart.01004.2005
  75. Brunner, Friedrich; Brás-Silva, Carmen; Cerdeira, Ana Sofia; Leite-Moreira, Adelino F.. "Cardiovascular endothelins: Essential regulators of cardiovascular homeostasis". Pharmacology & Therapeutics 111 2 (2006): 508-531. http://dx.doi.org/10.1016/j.pharmthera.2005.11.001.
    Published • 10.1016/j.pharmthera.2005.11.001
  76. Brás-Silva C; Fontes-Sousa AP; Moura C; Areias JC; Leite-Moreira AF; Brás-Silva, C.; Fontes-Sousa, A.P.; et al. "Impaired response to ET(B) receptor stimulation in heart failure: functional evidence of endocardial endothelial dysfunction?". Experimental Biology and Medicine 231 6 (2006): 893-896. http://europepmc.org/abstract/med/16741019.
  77. Bras-Silva, C.; Monteiro-Sousa, D.; Fontes-Sousa, A. P.; Leite-Moreira, A. F.. "The increase in myocardial distensibility induced by ET-1 is dependent on NO and prostaglandins release". Journal of Hypertension 24 (2006): S380-S380. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000240281002343&KeyUID=WOS:000240281002343.
  78. Fontes-Sousa, Ana Patricia; Bras-Silva, Carmen; Pires, Ana Luisa; Monteiro-Sousa, Daniela; Leite-Moreira, Adelino; Fontes-Sousa, A. P.; Bras-Silva, C.; Monteiro-Sousa, D.; Leite-Moreira, A. F.. "Urotensin II: A novel neurohumoral modulator of diastolic function". Circulation 114 18 (2006): 315-315. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000241792802128&KeyUID=WOS:000241792802128.
  79. Falcao-Pires, I.; Fontes-Sousa, P.; Bras-Silva, C.; Leite-Moreira, A.. "The acute increase in myocardial distensibility induced by beta-adrenergic stimulation is mediated by PKA, PKC and NA+/H+ exchanger". European Heart Journal 27 (2006): 846-846. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000240668406070&KeyUID=WOS:000240668406070.
  80. Bras-Silva, Carmen; Castro-Chaves, Paulo; Monteiro-Sousa, Daniela; Duarte, Ana Joana; Nunes, Pedro; Fontes-Sousa, Ana Patricia; Leite-Moreira, Adelino F.. "Disturbed myocardial response to endothelin-1 and angiotensin II in heart failure". Circulation 114 18 (2006): 310-310. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000241792802104&KeyUID=WOS:000241792802104.
  81. Fontes-Sousa, A. P.; Bras-Silva, C.; Monteiro-Sousa, D.; Leite-Moreira, A. F.. "The novel role of urotensin II on the diastolic properties of myocardium". European Heart Journal 27 (2006): 846-846. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000240668406069&KeyUID=WOS:000240668406069.
  82. Brás-Silva C; Leite-Moreira AF. "Modulation of the myocardial effects of selective ETB receptor stimulation and its implications for heart failure.". Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology (2005): http://europepmc.org/abstract/med/16335286.
  83. Carmen Brás-Silva; Adelino Leite-Moreira. "Modulação dos Efeitos Miocárdicos da Estimulação Selectiva dos Receptores ETB e suas Implicações na Insuficiência Cardíaca". (2005): https://repositorio-aberto.up.pt/handle/10216/1903.
  84. Brás-Silva C; Leite-Moreira AF. "[Nitric oxide in the physiopathology of myocardial dysfunction in heart failure].". Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology (2004): http://europepmc.org/abstract/med/15222254.
  85. Leite-Moreira, A.F.; Brás-Silva, C.. "Inotropic effects of ETB receptor stimulation and their modulation by endocardial endothelium, NO, and prostaglandins". American Journal of Physiology - Heart and Circulatory Physiology 287 3 56-3 (2004): http://www.scopus.com/inward/record.url?eid=2-s2.0-4143052416&partnerID=MN8TOARS.
    10.1152/ajpheart.00563.2003
  86. Leite-Moreira AF; Bras-Silva C; Pedrosa CA; Rocha-Sousa AA; Leite-Moreira, A.F.; Brás-Silva, C.; Pedrosa, C.A.; Rocha-Sousa, A.A.. "ET-1 increases distensibility of acutely loaded myocardium: a novel ETA and Na+/H+ exchanger-mediated effect.". American Journal of Physiology - Heart and Circulatory Physiology 284 4 53-4 (2003): http://europepmc.org/abstract/med/12595285.
    10.1152/ajpheart.00715.2002
  87. Leite-Moreira AF; Brás-Silva C; Pedrosa C; Leite-Moreira, A.F.; Brás-Silva, C.; Pedrosa, C.. "Myocardial effects of ETB receptor stimulation.". Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 21 9 (2002): 1009-1016. http://europepmc.org/abstract/med/12416272.
  88. Leite-Moreira, AF; Pedrosa, CA; Bras-Silva, C. "Selective ETB receptor stimulation induces a nitric oxide independent negative inotropic effect". European Heart Journal 22 (2001): 379-379. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000170988301451&KeyUID=WOS:000170988301451.
  89. Leite-Moreira, A.F.; Rocha-Sousa, A.; Pedrosa, C.; Brás-Silva, C.; Pinho, P.; Pinheiro-Torres, J.; Teixeira-Bastos, P.. "Mechanisms underlying endothelin-1 effects on myocardial function | Mecanismos subjacentes aos efeitos da endotelina-1 sobre a função miocárdica.". Revista portuguesa de cardiologia : orgão oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology 20 3 (2001): 291-295. http://www.scopus.com/inward/record.url?eid=2-s2.0-19244374360&partnerID=MN8TOARS.
  90. Leite-Moreira, AF; Rocha-Sousa, A; Bras-Silva, C; Pedrosa, CA; Pinho, P; Pinheiro-Torres, J; Bastos, P. "Endothelin-1 increases diastolic distensibility of human and non-human myocardium in conditions of cardiac overload". Journal of the American College of Cardiology 35 2 (2000): 204A-205A. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000085209700786&KeyUID=WOS:000085209700786.
  91. Leite-Moreira, A; Rocha-Sousa, A; Pedrosa, C; Bras-Silva, C; Pinho, P; Pinheiro-Torres, J; Bastos, P. "Mechanisms underlying the increase in myocardial distensibility induced by endothelin-1 in conditions of cardiac overload". European Heart Journal 21 (2000): 538-538. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000089136602092&KeyUID=WOS:000089136602092.
Thesis / Dissertation
  1. Brás-Silva, Carmen. "Efeitos Miocárdicos da Endotelina-1 e suas Implicações na Fisiopatologia da Insuficiência Cardíaca / Myocardial Effects of endothelin-1 and their implications in the pathophysiology of heart failure". PhD, Universidade do Porto Faculdade de Medicina, 2007.
  2. Brás-Silva, Carmen. "Nutrition and bone mass". Degree, Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, 1999.
Activities

Association member

Society Organization name Role
2022/12/01 - Current Portuguese Physiological Society Member o Direction (secretary)
2016/01/01 - Current European Respiratory Society Member
2015/01/01 - Current Sociedade Portuguesa de Pneumologia / Portuguese Society of Pulmonology Member
2013/01/01 - Current Working group on Myocardial function - European Society of Cardiology Member
2013/01/01 - Current Working group on Cellular Biology of the Heart -European Society of Cardiology
2012/01/01 - Current Eurpean Society of Cardiology Member
2012/01/01 - Current Heart Failure Association of the ESC (European Society of Cardiology) Member
2010/01/01 - Current Associação Portuguesa de Nutrição / Portuguese Nutrition Society Member
2008/01/01 - Current Sociedade Portuguesa de Cardiologia /Portuguede Society of Cardiology Member

Committee member

Activity description
Role 		Institution / Organization
2021/02/19 - Current Director of the Master Degree in Clinical Nutrition
Director
 Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2021/02/19 - Current Member of the Monitoring Committee of Master Degree in Clinical Nutrition
Member
 Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2015/09/01 - Current Scientific Committee Member for the Doctoral programe in Cardiovascular Sciences
Member
 Universidade do Porto Faculdade de Medicina, Portugal
2010/09/01 - Current Scientific Committee Member for the Master Degree in Cardiovascular Pathophisiology
Member
 Universidade do Porto Faculdade de Medicina, Portugal
2008/09/01 - Current Scientific Committee Member for the Master Degree in Clinical Nutrition
Member
 Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2011/09/01 - 2019/08/31 Scientific Committee Member for the Doctoral Programe in Clinical Nutrition
Member
 Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal

Conference scientific committee

Conference name Conference host
2023/11/14 - 2023/11/14 SEMINAR Learning and Teaching in Physiology Portuguese Society of Physiology
2022/11/11 - 2022/11/12 2nd International Meeting of the Portuguese Society of Physiology Portuguese Society of Physiology
2022/04/22 - 2022/04/24 CPC 2022- Congresso Português de Cardiologia 2020 /Portuguese Congress of Cardiology 2022 Sociedade Poruguesa de Cadiologia / Portuguese Society of Cardiology
2021/04/30 - 2021/05/02 CPC 2021- Congresso Português de Cardiologia 2020 /Portuguese Congress of Cardiology 2021 Sociedade Poruguesa de Cadiologia / Portuguese Society of Cardiology
2019/09/01 - 2020/11/30 CPC 2020 - Congresso Português de Cardiologia 2020 /Portuguese Congress of Cardiology 2020 Sociedade Poruguesa de Cadiologia / Portuguese Society of Cardiology
2019/11/22 - 2019/11/24 SPCCTV 4D Visions - Sociedade Portuguesa de Cirurgia Cardiotorácica e Vascular Sociedade Portuguesa de Cirurgia Cardiotorácica e Vascular
2019/04/27 - 2019/04/29 CPC 2019 - Congresso Português de Cardiologia 2019 / Portuguese Congress of Cardiology 2019 Sociedade Poruguesa de Cadiologia / Portuguese Society of Cardiology
2018/04/28 - 2018/04/30 CPC 2018 - Congresso Português de Cardiologia 2018 / Portuguese Congress of Cardiology 2018 Sociedade Poruguesa de Cadiologia / Portuguese Society of Cardiology
2009/05/28 - 2009/05/29 VIII Congresso de Nutrição e Alimentação da Associação Portuguesa de Nutricionistas

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2015/09/09 - Current Investigação Laboratorial - Avaliação funcional in vitro / "Laboratory Research - In Vitro Functional Evaluation" Medicina Universidade do Porto Faculdade de Medicina, Portugal
2013/09/01 - Current Ciência em Animais de Laboratório /"Science in Laboratory Animals" Fisiopatologia Cardiovascular (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2013/09/01 - Current Cardiovascular Risk Ciências Cardiovasculares (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2011/09/01 - Current Mecanismos Moleculares na Insuficiência Cardíaca / " Molecular Mechanisms in Heart Failure" Fisiopatologia Cardiovascular (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2011/09/01 - Current Avaliação da função muscular cardíaca e vascular in vitro / "Evaluation of cardiac and vascular muscle function in vitro" Ciências Cardiovasculares (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2010/09/01 - Current Metodologia de Investigação / "Research Metodologies" Nutrição Clínica (Mestrado integrado) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2010/09/01 - Current Temas Atuais em Nutrição / " Current topics in nutrition" Nutrição Clínica (Mestrado integrado) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2010/09/01 - Current Modelos Animais de Doença Cardiovascular / "Animal Models of Cardiovascular Disease" Ciências Cardiovasculares (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2010/09/01 - Current Avaliação da Função Cardiovascular in vitro II / "Evaluation of Cardiovascular Function in vitro II" Fisiopatologia Cardiovascular (Mestrado integrado) Universidade do Porto Faculdade de Medicina, Portugal
2007/09/01 - Current Physiology I Ciências da Nutrição (Licenciatura) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2007/09/01 - Current Physiology II Ciências da Nutrição (Licenciatura) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2014/09/01 - 2017/07/31 Physiology Enfermagem (Licenciatura) Escola Superior de Enfermagem do Porto, Portugal
2010/09/01 - 2012/07/31 Estado nutricional e doença cardiovascular / "Nutritional status and cardiovascular disease" Ciências Cardiovasculares (Doutoramento) Universidade do Porto Faculdade de Medicina, Portugal
2007/10/01 - 2009/07/31 Physiology Ciências da Nutrição (Licenciatura) Universidade Católica Portuguesa Escola Superior de Biotecnologia, Portugal
2007/09/01 - 2009/07/01 Physiology Enfermagem (Licenciatura) Escola Superior de Enfermagem do Porto, Portugal
2004/09/01 - 2007/08/08 Physiology Ciências da Nutrição (Licenciatura) Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2000/09/01 - 2007/07/31 Anatomofisiologia / " Anatomy and physiology" Enfermagem (Licenciatura) Escola Superior de Enfermagem do Porto, Portugal