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Rui Adão. Completed the Mestrado integrado in Fisiopatologia Cardiovascular in 2013 by Universidade do Porto Faculdade de Medicina, Doutoramento in Ciências Cardiovasculares in 2019/01/28 by Universidade do Porto Faculdade de Medicina and Licenciatura in Biologia in 2011 by Universidade de Aveiro. Is Researcher in Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular and Marie Sklodowska-Curie Postdoctoral Fellow at Department of Pharmacology and Toxicology in Universidad Complutense de Madrid Facultad de Medicina. Published 36 articles in journals. Has 1 book(s). Organized 3 event(s). Participated in 82 event(s). Has received 23 awards and/or honors. Participates and/or participated as Post-doc Fellow in 1 project(s), Principal investigator in 1 project(s) and Researcher in 11 project(s). Works in the area(s) of Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Physiology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: Ciências médicas e da saúde; Medical and Health sciences; Ciências da saúde; Health sciences; Ciências médicas e da saúde::Ciências da saúde; Medical and Health sciences::Health sciences; basic research; cardiovascular system; .
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Identification

Personal identification

Full name
Rui Adão
Gender
Male

Citation names

  • Adão, Rui

Author identifiers

Ciência ID
E11C-E68E-8232
ORCID iD
0000-0003-2203-436X
Google Scholar ID
https://scholar.google.com/citations?user=u0a2ch4AAAAJ

Email addresses

  • ruiadao@med.up.pt (Professional)
  • ruimigueladao@gmail.com (Personal)

Addresses

  • Faculdade de Medicina da Universidade do Porto - Dp. de Cirurgia e Fisiologia . Rua Professor Hernâni Monteiro , 4200-319, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Physiology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2019/01/28
Concluded
 Ciências Cardiovasculares (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
"“Pathophysiological role of urocortin-2 system in pulmonary hypertension – therapeutic implications”" (THESIS/DISSERTATION)
 Aprovado
2019 - 2019
Concluded
 Federation of European Laboratory Animal Science Associations (FELASA Functions A, B and D) accreditation course (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013
Concluded
 Fisiopatologia Cardiovascular (Mestrado integrado)
Universidade do Porto Faculdade de Medicina, Portugal
""Evaluation of intrinsic myocardial properties in pulmonary hypertension - modulation by neuregulin 1"" (THESIS/DISSERTATION)
 19
2012 - 2012
Concluded
 Pedagogical Aptitude training course - IEFP certified trainer (CCP) (Outros)
Centro de Formaçao Comenius, Portugal
2011
Concluded
 Biologia (Licenciatura)
Universidade de Aveiro, Portugal
""Hipertensão Pulmonar e Insuficiência cardíaca - mecanismos fisiopatológicos e regulação neurohumoral"" (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2022 - Current Researcher (Research) Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2019/07/01 - 2022 Postdoc (Research) Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2019/09/01 - 2019/12/31 Visiting Researcher (Research) Medizinische Universität Graz Zentrum für Physiologische Medizin, Austria
2017/09/01 - 2017/12/21 Visiting Researcher (Research) Medizinische Universität Graz Zentrum für Physiologische Medizin, Austria

Others

Category
Host institution 		Employer
2022 - Current Marie Sklodowska-Curie Postdoctoral Fellow at Department of Pharmacology and Toxicology Universidad Complutense de Madrid Facultad de Medicina, Spain
2014/08/01 - 2019/01/28 FCT PhD scholarship; Project: "Pathophysiological role of urocortin-2 system in pulmonary hypertension – therapeutic implications"; Ref: SFRH/BD/96403/2013 Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2013/08/01 - 2014/07/31 FCT Master Scholarship; Project: “Papel fisiopatológico e potencial terapêutico da urocortina 2 na hipertensão pulmonar”, Ref: PTDC/DTP-FTO/0130/2012 Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2010/09/13 - 2011/07/18 Curricular Internship; Advisor: Prof Carmen Brás Silva; Final grade: 20 Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
2009/09/21 - 2010/07/06 Curricular Internship; Molecular Biology techniques; Advisor: Prof. Doutor Manuel Santos; Final grade: 17 valores Universidade de Aveiro Departamento de Biologia, Portugal
2009/05/04 - 2010/05/04 Research Integration scholarship; Advisor: Prof Eduardo Silva; Project: Lead availability in soils from Portugal's Centre Region with special reference to bioaccessibility" Universidade de Aveiro Departamento de Geociências, Portugal
Projects

Grant

Designation Funders
2023/03 - Current Relaxin-2 and Pulmonary Arterial Hypertension: pathophysiological role and therapeutic potential
2022.08921.PTDC
Principal investigator
Universidade do Porto Unidade de Investigação e Desenvolvimento Cardiovascular, Portugal
Ongoing
2022/10 - Current Modulation of potassium channels for pulmonary artery hypertension
--
Post-doc Fellow
Universidad Complutense de Madrid Facultad de Medicina, Spain
Ongoing
2019 - Current ERA-CVD-funded project MINOTAUR- Metabolic Therapy for Diastolic Heart Failure
--
Researcher
2018 - Current IMPAcT - Insight in the pathophysiological role of Mir-146a in Pulmonary Arterial Hypertension
PTDC/MED-FSL/31719/2017
Researcher
Associação para a Inovação e Desenvolvimento da FCT
2017/02/01 - Current Effect of GGF2 on pulmonary artery banding-induced right ventricle hypertrophy - Collaboration with ACORDA Pharmaceutics
..
Researcher
2017 - Current Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension
-
Researcher
2016 - Current Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension
-
Researcher
2015/01/01 - Current Efficacy of the thromboxane receptor antagonist NTP42 in experimental pulmonary arterial hypertension - Collaboration with ATXA Pharmaceutics
--
Researcher
Concluded
2017 - 2020 ß-3 adrenoceptors- a therapeutic target for pulmonary arterial hypertension
-
Researcher
2013/07 - 2018/10 Pathophysiological role and therapeutic potential of urocortin 2 in pulmonary hypertension
grant.Provided by PTCRIS: 124203
Researcher
2014 - 2017 Left intraventricular diastolic and systolic pressure gradients in human heart failure
-
Researcher
2012 - 2017 Role of the neuregulin system in pulmonary arterial hypertension
PTDC/SAU-FCF/100442/2008
Researcher
2008 - 2010 Lead availability in soils from Portugal's Centre Region with special reference to bioaccessibility
-
Researcher
Universidade de Aveiro Departamento de Geociências, Portugal
Outputs

Publications

Book
  1. Adão, R.; Maia-Rocha, C.; Santos-Ribeiro, D.; Mendes-Ferreira, P.; Leite-Moreira, A.F.; Brás-Silva, C.. Cardiotoxicity of cancer chemotherapy–Recent developments. 2016.
    10.2174/9781681081656116070004
Conference abstract
  1. Adão, Rui; Glória Conceição; Daniela Silva Miranda; Luís D. Pimentel; Pedro Vaz Salvador; Carolina Maia-Rocha; Pedro Mendes-Ferreira; et al. "Role of urocortin-2 in heart failure with preserved ejection fraction". Paper presented in Portuguese Society of Cardiology Meeting, 2020.
    Published
  2. Adão, Rui. "Effects of urocortin-2 on cellular Ca2+ homeostasis in right heart failure induced by pulmonary artery hypertension". Paper presented in Eur Respir J, 2018.
    Published
  3. Adão, Rui. "Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension". Paper presented in Eur Respir J, 2018.
    Published
  4. Adão, Rui. "Urocortin-2 improves right ventricular function and attenuates experimental pulmonary arterial hypertension". Paper presented in Cardiovascular Research, 2016.
    Published
  5. Adão, Rui. "The right ventricle molecular changes associated with pulmonary arterial hypertension are attenuated by Urocortin 2 treatment". Paper presented in European heart journal, 2016.
  6. Adão, Rui. "Molecular mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension". Paper presented in Cardiovascular Research, 2016.
    Published
  7. Adão, Rui. "The right ventricle molecular changes associated with pulmonary arterial hypertension are attenuated by Urocortin-2 treatment". Paper presented in European Journal of Heart Failure, 2016.
  8. Adão, Rui. "Urocortin-2 treatment reduces right ventricular dysfunction in pulmonary arterial hypertension". Paper presented in European heart journal, 2016.
    Published
  9. Adão, Rui. "Urocortin-2 Improves Right Ventricular Function In Pulmonary Arterial Hypertension". Paper presented in American journal of respiratory and critical care medicine, 2016.
  10. Adão, Rui. "Microrna-146a Expression Is Increased In Human Pah". Paper presented in American journal of respiratory and critical care medicine, 2016.
    Published
  11. Adão, Rui. "Pulmonary artery banding-induced adaptive and maladaptive remodelling of the right ventricle in the rat". Paper presented in European Journal of Heart Failure, 2016.
  12. Adão, Rui. "Urocortin-2 attenuates right ventricular dysfunction in pulmonary arterial hypertension". Paper presented in European Journal of Heart Failure, 2016.
    Published
  13. Adão, Rui. "Neuregulin-1 improves right ventricular function and attenuates monocrotaline-induced pulmonary arterial hypertension". Paper presented in European Journal of Heart Failure, 2015.
    Published
  14. Adão, Rui. "Urocortin-2 improves right ventricular function in pulmonary arterial hypertension". Paper presented in European Journal of Heart Failure, 2015.
  15. Adão, Rui. "Urocortin-2 improves right ventricular function in pulmonary arterial hypertension". Paper presented in European heart journal, 2015.
    Published
  16. Adão, Rui. "The right ventricle molecular changes associated with pulmonary arterial hypertension are attenuated by neuregulin-1 treatment". Paper presented in European heart journal, 2014.
    Published
  17. Adão, Rui. "Molecular mechanisms underlying the beneficial effects of neuregulin-1 in pulmonary arterial hypertension". Paper presented in Cardiovascular Research Journal, 2014.
    Accepted
  18. Adão, Rui. "Neuregulin-1 preserves right ventricular diastolic function in animal model of pulmonary arterial hypertension". Paper presented in European heart journal, 2014.
    Published
  19. Adão, Rui. "Neuregulin-1 attenuates right ventricle hypertrophy in a model of pulmonary artery banding". Paper presented in European Journal of Heart Failure, 2014.
    Published
  20. Adão, Rui. "Urocortin-2 Improves Right Ventricular Function in Pulmonary Arterial Hypertension". Paper presented in Circulation, 2014.
    Published
  21. Adão, Rui. ". Neuregulin-1 ameliorates right ventricular diastolic dysfunction in pulmonary arterial hypertension". Paper presented in Cardiovascular Research, 2014.
    Published
  22. Adão, Rui. "Neuregulin-1 treatment reduces right ventricular dysfunction in pulmonary arterial hypertension". Paper presented in European Journal of Heart Failure, 2013.
  23. Adão, Rui. "Neuregulin-1 Chronic Treatment Improves Right Ventricle Cardiomyocyte Function in Pulmonary Hypertension". Paper presented in Circulation, 2013.
    Published
  24. Adão, Rui. "Neuregulin-1 modulates right ventricle cardiomyocyte function in pulmonary arterial hypertension". Paper presented in European heart journal, 2013.
    Published
  25. Adão, Rui. "Neuregulin attenuates pulmonary endothelial dysfunction in pulmonary hypertension". Paper presented in European heart journal, 2012.
    Published
  26. Adão, Rui. "Neuregulin attenuates right ventricular hypertrophy and dysfunction in an experimental model of pulmonary hypertension". Paper presented in Cardiovascular Research, 2012.
  27. Adão, Rui. "NRG1 improves right ventricular function in pulmonary hypertension". Paper presented in European heart journal, 2012.
  28. Adão, Rui. "Neuregulin Attenuates Right Ventricular and Pulmonary Endothelial Dysfunction in an Experimental Model of Pulmonary Hypertension". Paper presented in Circulation, 2012.
Journal article
  1. Adão, Rui; Kraler SC; Abdellatif, Mahmoud; Ljubojevic-Holzer; Adelino F. Leite-Moreira; Simon Sedej; Brás-Silva, Carmen. "Acute and chronic effects of urocortin-2 therapy on intracellular calcium homeostasis in right heart failure induced by pulmonary arterial hypertension". Scientific Reports (2023):
    Under revision
  2. Pedro Mendes-Ferreira; Adão, Rui; Alice Miranda; Adelino F. Leite-Moreira; Carmen Brás Silva. "Comprehensive cardiovascular function analysis in rodents with right heart failure". Journal of Visualized Experiments (2023):
    Under revision
  3. Eamon P. Mulvaney; Fabiana Renzo; Rui Adão; Emilie Dupre; Lucia Bialesova; Viviana Salvatore; Helen M. Reid; et al. "The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload". Frontiers in Cardiovascular Medicine 9 (2022): http://dx.doi.org/10.3389/fcvm.2022.1063967.
    10.3389/fcvm.2022.1063967
  4. Rita Figueiredo; Rui Adão; Adelino F. Leite-Moreira; Jennifer Mâncio; Carmen Brás-Silva. "Candidate microRNAs as prognostic biomarkers in heart failure: A systematic review". Revista Portuguesa de Cardiologia 41 10 (2022): 865-885. http://dx.doi.org/10.1016/j.repc.2021.03.020.
    10.1016/j.repc.2021.03.020
  5. Rui Adão; Bart Bijnens. "At the heart of artificial intelligence: the future might well be based on synthetic cells". Cardiovascular Research (2022): https://doi.org/10.1093/cvr/cvac129.
    10.1093/cvr/cvac129
  6. Joana Santos-Gomes; Inês Gandra; Rui Adão; Frédéric Perros; Carmen Brás-Silva. "An Overview of Circulating Pulmonary Arterial Hypertension Biomarkers". Frontiers in Cardiovascular Medicine 9 (2022): http://dx.doi.org/10.3389/fcvm.2022.924873.
    10.3389/fcvm.2022.924873
  7. Rúben Almeida-Pinto; Adelino F. Leite-Moreira; Carmen Brás-Silva; Rui Adão. "Pulmonary Valve Replacement: A New Paradigm with Tissue Engineering". Current Problems in Cardiology (2022): 101212-101212. https://doi.org/10.1016/j.cpcardiol.2022.101212.
    10.1016/j.cpcardiol.2022.101212
  8. Joana Gomes; Hélène Le Ribeuz; Bras-Silva C; Fabrice Antigny; Adão R. "Role of Ion Channel Remodeling in Endothelial Dysfunction Induced by Pulmonary Arterial Hypertension". Biomolecules (2022): https://www.mdpi.com/2218-273X/12/4/484.
    10.3390/biom12040484
  9. Pedro Vaz-Salvador; Rui Adão; Inês Vasconcelos; Adelino F. Leite-Moreira; Carmen Brás-Silva. "Heart Failure with Preserved Ejection Fraction: a Pharmacotherapeutic Update". Cardiovascular Drugs and Therapy (2022): https://doi.org/10.1007/s10557-021-07306-8.
    10.1007/s10557-021-07306-8
  10. Inês Vasconcelos; Rui Adão; Miriam T. Rademaker; Adelino F. Leite-Moreira; Ana Patrícia Fontes-Sousa; Carmen Brás-Silva. "Urocortins as biomarkers in cardiovascular disease". Clinical Science (2022): https://doi.org/10.1042/CS20210732.
    10.1042/CS20210732
  11. Adão R; Archer SL. "Corrigendum to: Scientist on the spot: Exploring the cause and cure for pulmonary arterial hypertension.". Cardiovascular research (2021): http://europepmc.org/abstract/med/34143877.
    10.1093/cvr/cvab191
  12. Rui Adão; Stephen L Archer. "Scientist on the Spot: Exploring the cause and cure for pulmonary arterial hypertension". Cardiovascular Research 117 6 (2021): e82-e83. https://doi.org/10.1093/cvr/cvab091.
    10.1093/cvr/cvab091
  13. Rui Adão; Paul R Stoddart; Karlheinz Peter. "Avalanching nanoparticles bring new light to cardiovascular imaging". Cardiovascular Research 117 5 (2021): e60-e63. https://doi.org/10.1093/cvr/cvab092.
    10.1093/cvr/cvab092
  14. Pintalhao M; Maia-Rocha C; Castro-Chaves P; Adão R; Barros AS; Clara Martins R; Leite-Moreira A; Bettencourt P; Bras-Silva C. "Urocortin-2 in Acute Heart Failure: Role as a Marker of Volume Overload and Pulmonary Hypertension.". Current problems in cardiology (2021): http://europepmc.org/abstract/med/33994037.
    10.1016/j.cpcardiol.2021.100860
  15. Abdellatif M; Trummer-Herbst V; Koser F; Durand S; Adão R; Vasques-Nóvoa F; Freundt JK; et al. "Nicotinamide for the treatment of heart failure with preserved ejection fraction.". Science translational medicine (2021): http://europepmc.org/abstract/med/33568522.
    10.1126/scitranslmed.abd7064
  16. Rui Adão; Hafid Ait-Oufella. "Scientists on the Spot: Inflammation in atherosclerosis". Cardiovascular Research 117 1 (2021): e7-e8. https://doi.org/10.1093/cvr/cvaa314.
    10.1093/cvr/cvaa314
  17. Lambert M; Mendes-Ferreira P; Ghigna MR; LeRibeuz H; Adão R; Boet A; Capuano V; et al. "Kcnk3 Dysfunction Exaggerates The Development Of Pulmonary Hypertension Induced By Left Ventricular Pressure Overload.". Cardiovascular research (2021): http://europepmc.org/abstract/med/33483721.
    10.1093/cvr/cvab016
  18. Adão R; Marian AJ. "Highlights of American Heart Association Scientific Sessions 2020: a virtual experience.". Cardiovascular research (2021): http://europepmc.org/abstract/med/33426562.
    10.1093/cvr/cvaa346
  19. Mulvaney EP; Reid HM; Bialesova L; Mendes-Ferreira P; Adão R; Brás-Silva C; Kinsella BT. "Efficacy of the thromboxane receptor antagonist NTP42 alone, or in combination with sildenafil, in the sugen/hypoxia-induced model of pulmonary arterial hypertension.". European journal of pharmacology (2020): http://europepmc.org/abstract/med/33121950.
    10.1016/j.ejphar.2020.173658
  20. Leite-Moreira AF; Adão R. "Mobile cardiology during the COVID-19 outbreak.". Cardiovascular research (2020): http://europepmc.org/abstract/med/32980878.
    10.1093/cvr/cvaa270
  21. Martinho S; Adão R; Leite-Moreira AF; Brás-Silva C; Sofia Martinho; Adão, Rui; Adelino F. Leite-Moreira; Carmen Brás-Silva. "Persistent Pulmonary Hypertension of the Newborn: Pathophysiological Mechanisms and Novel Therapeutic Approaches.". Frontiers in pediatrics (2020): http://europepmc.org/abstract/med/32850518.
    Submitted • 10.3389/fped.2020.00342
  22. Adão, Rui. "Inside the heart of COVID-19.". Cardiovascular research (2020): https://doi.org/10.1093/cvr/cvaa086.
    10.1093/cvr/cvaa086
  23. Rui Adão; Pedro Mendes-Ferreira; Carolina Maia-Rocha; Diana Santos-Ribeiro; Patrícia Gonçalves Rodrigues; André Vidal-Meireles; Cláudia Monteiro-Pinto; et al. "Neuregulin-1 attenuates right ventricular diastolic stiffness in experimental pulmonary hypertension". Clinical and Experimental Pharmacology and Physiology (2019): https://doi.org/10.1111/1440-1681.13043.
    10.1111/1440-1681.13043
  24. Ramjug, S.; Adão, R.; Lewis, R.; Coste, F.; De Man, F.; Jimenez, D.; Sitbon, O.; Delcroix, M.; Vonk-Noordegraaf, A.. "Highlights from the ERS international congress 2018: Assembly 13 - pulmonary vascular diseases". ERS Monograph 5 1 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85067942271&partnerID=MN8TOARS.
    10.1183/23120541.00202-2018
  25. Hautefort, A.; Mendes-Ferreira, P.; Sabourin, J.; Manaud, G.; Bertero, T.; Rucker-Martin, C.; Riou, M.; et al. "Bmpr2 Mutant Rats Develop Pulmonary and Cardiac Characteristics of Pulmonary Arterial Hypertension". Circulation 139 7 (2019): 932-948. http://www.scopus.com/inward/record.url?eid=2-s2.0-85058621612&partnerID=MN8TOARS.
    10.1161/CIRCULATIONAHA.118.033744
  26. Monteiro-Pinto, C.; Adão, R.; Leite-Moreira, A.F.; Brás-Silva, C.. "Cardiovascular Effects of Urocortin-2: Pathophysiological Mechanisms and Therapeutic Potential". Cardiovascular Drugs and Therapy 33 5 (2019): 599-613. http://www.scopus.com/inward/record.url?eid=2-s2.0-85073934389&partnerID=MN8TOARS.
    10.1007/s10557-019-06895-9
  27. Corremans R; Adão R; De Keulenaer GW; Leite-Moreira AF; Brás-Silva C. "Update on pathophysiology and preventive strategies of anthracycline-induced cardiotoxicity.". Clinical and experimental pharmacology & physiology (2018): http://europepmc.org/abstract/med/30244497.
    10.1111/1440-1681.13036
  28. Adão, R.; Mendes-Ferreira, P.; Santos-Ribeiro, D.; Maia-Rocha, C.; Pimentel, L.D.; Monteiro-Pinto, C.; Mulvaney, E.P.; et al. "Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension". Cardiovascular Research 114 8 (2018): 1165-1177. http://www.scopus.com/inward/record.url?eid=2-s2.0-85050947222&partnerID=MN8TOARS.
    10.1093/cvr/cvy076
  29. Lambert, M.; Boet, A.; Rucker-Martin, C.; Mendes-Ferreira, P.; Capuano, V.; Hatem, S.; Adão, R.; et al. "Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension". Cardiovascular Research 114 6 (2018): 880-893. http://www.scopus.com/inward/record.url?eid=2-s2.0-85045412406&partnerID=MN8TOARS.
    10.1093/cvr/cvy016
  30. Guerra M; Mendes-Ferreira P; Adão R; Pereira E; Vieira M; Lourenço AP; Brás-Silva C; et al. "Improvement in left intraventricular pressure gradients after aortic valve replacement in aortic stenosis patients.". Experimental physiology 102 4 (2017): 411-421. http://europepmc.org/abstract/med/28194824.
    10.1113/ep086191
  31. Santos-Ribeiro D; Mendes-Ferreira P; Maia-Rocha C; Adão R; Leite-Moreira AF; Brás-Silva C. "Pulmonary arterial hypertension: Basic knowledge for clinicians.". Archives of cardiovascular diseases (2016): http://europepmc.org/abstract/med/27595464.
    10.1016/j.acvd.2016.03.004
  32. Mendes-Ferreira P; Santos-Ribeiro D; Adão R; Maia-Rocha C; Mendes-Ferreira M; Sousa-Mendes C; Leite-Moreira AF; Brás-Silva C. "Distinct right ventricle remodeling in response to pressure overload in the rat.". American Journal of Physiology - Heart and Circulatory Physiology (2016): http://europepmc.org/abstract/med/27199115.
    10.1152/ajpheart.00089.2016
  33. Mendes-Ferreira P; Maia-Rocha C; Adão R; Mendes MJ; Santos-Ribeiro D; Alves BS; Cerqueira RJ; et al. "Neuregulin-1 improves right ventricular function and attenuates experimental pulmonary arterial hypertension.". Cardiovascular research (2016): http://europepmc.org/abstract/med/26503987.
    10.1093/cvr/cvv244
  34. Adão R; Santos-Ribeiro D; Rademaker MT; Leite-Moreira AF; Brás-Silva C. "Urocortin 2 in cardiovascular health and disease.". (2015): http://europepmc.org/abstract/med/25748088.
    10.1016/j.drudis.2015.02.012
  35. Adão R; de Keulenaer G; Leite-Moreira A; Brás-Silva C. "Cardiotoxicity associated with cancer therapy: pathophysiology and prevention strategies.". (2013): http://europepmc.org/abstract/med/23623503.
    10.1016/j.repc.2012.11.002
  36. Patinha C; Reis AP; Dias C; Cachada A; Adão R; Martins H; Ferreira da Silva E; Sousa AJ. "Lead availability in soils from Portugal's Centre Region with special reference to bioaccessibility.". (2012): http://europepmc.org/abstract/med/21989856.
    10.1007/s10653-011-9431-1
Thesis / Dissertation
  1. Rui Miguel da Costa Adão. "Pathophysiological role of urocortin-2 System in pulmonary hypertension - therapeutic implications". PhD, 2019. https://hdl.handle.net/10216/119067.
  2. Rui Miguel da Costa Adão. "Modulação da função ventricular direita pela neuregulina - 1 - implicações terapêuticas na hipertensão pulmonar". Master, 2013. https://repositorio-aberto.up.pt/handle/10216/87920.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019 Invited Presentation - Are animal models in pulmonary arterial hypertension relevant to the clinical disease? Animal Models of Disease - 2nd Edition. Universidade de Aveiro, 6 Março 2019. Aveiro, Portugal.
2018 Invited Presentation - Presentation of the work “Pathophysiological role of urocortin-2 system in pulmonary hypertension – therapeutic implications” in National Science Summit 2018 (Lisbon Congress Center)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2022/04 - Current Ambassador of Frontiers in CardioVascular Biomedicine Congress (2022/04)
Conference (Member of the Organising Committee)
2013 - Current Coordinator of the Project “Quando o coração falha: do laboratório à clínica” in School of Life and Health Sciences (every year) (2013) Universidade do Porto, Portugal
2012 - Current Coordinator of the Project “Investigar com o Coração” in Junior University (every year) (2012)
Workshop
 Universidade do Porto, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/09 - Current Rego B, Mendes-Ferreira P, Adão R, Maia-Rocha C, Santos-Gomes J, Vasconcelos I, Gandra I, Vaz-Salvador P, Leite-Moreira A, Brás-Silva C. The role of miR-146a in the pathophysiology of pulmonary arterial hypertension. Sixteenth - Young European Scientist – Meeting. Porto, Portugal
Congress
2021/09 - Current Vasconcelos I, Vaz-Salvador P, Adão R, Conceição G, Miranda-Silva D, Santos-Gomes J, Rego B, Maia-Rocha C, Mendes-Ferreira P, Leite-Moreira AF, Fontes-Sousa AP, Brás-Silva C. Pathophysiological and therapeutic implications of Urocortin-2 in Heart Failure with Preserved Ejection Fraction. YES meeting 16th edition – Young European Scientist Meeting. Porto, Portugal
Congress
2021/02 - Current Rego B, Mendes-Ferreira P, Adão R, Maia-Rocha C, Santos-Gomes J, Vasconcelos I, Gandra I, Vaz-Salvador P, Leite-Moreira A, Brás-Silva C. The role of miR-146a in the pathophysiology of pulmonary arterial hypertension. IJUP. 2021; Porto, Portugal.
Congress
2021/02 - Current Vasconcelos I, Adão R, Fontes-Sousa AP, Brás-Silva C. IJUP 14th edition. Ucns as biomarkers in cardiovascular disease. 2021; Porto, Portugal.
Congress
2020 - Current Adão R, Mendes-Ferreira P, Pinto AR, Leite-Moreira AF, Brás-Silva C. Urocortin-2 modulates altered myofilament calcium sensitivity in right heart failure induced by pulmonary arterial hypertension. Frontiers in CardioVascular Biomedicine Congress 2020. Virtual Congress
Congress
2020 - Current Adao R, Conceicao G, Miranda-Silva, Pimentel LD, Vaz-Salvador P, Maia-Rocha C, Mendes-Ferreira P, Lourenco AP, Falcao-Pires I, Leite-Moreira AF, Brás-Silva C. Role of urocortin-2 in heart failure with preserved ejection fraction. Congresso Português de Cardiologia 2020. Best Young Basic Researcher Session. Virtual Congress
Conference
2019 - Current Adão R, Kraler SC, Senka H, Leite-Moreira A, Sedej S, Brás-Silva C. Effects of urocortin-2 on cellular Ca2+ homeostasis in right heart failure induced by pulmonary artery hypertension. Congresso Português de Cardiologia 2019. Best Young Basic Researcher Session. Vilamoura
2018 - Current Adão R, Kraler SC, Senka H, Leite-Moreira A, Sedej S, Brás-Silva C. Effects of urocortin-2 on cellular Ca2+ homeostasis in right heart failure induced by pulmonary artery hypertension. ERS (European Respiratory Society) International Congress 2018. Paris
2018 - Current Pinto R, Maia-Rocha C, Adão R, Mendes-Ferreira P, Leite-Moreira AF, Brás-Silva C. Expression of GLUT1 and GLUT4 in right ventricle in Pulmonary Arterial Hypertension – Effects of chronic treatment with NRG1. IJUP’ 18 – 11th Meeting of Young Researchers of University of Porto. Porto, Portugal.
2018 - Current Pintalhão M, Maia-Rocha C, Martins R, Adão R, Barros A, Leite-Moreira, Bettencourt P, Castro-Chaves P, Brás-Silva C. Serum Urocortin-2 is associated with Volume Overload and Pulmonary Hypertension in Acute Heart Failure. AHA (American Heart Association) Scientific Sessions 2018. Chicago, EUA.
2018 - Current Mendes-Ferreira P, Adão R, Quarck R, Belge C, Delcroix M, BráS-Silva C. Activation of the Beta-3 adrenoceptor in experimental pulmonary hypertension Pulmonary hypertension. ERS (European Respiratory Society) International Congress 2018. Paris, França.
2018 - Current Adão R, Mendes-Ferreira P, Santos-Ribeiro D, Maia-Rocha C, Pimentel L, Pinto C, Mulvaney EP, Reid HM, Kinsella BT, Potus F, Breuils-Bonnet S, Rademaker MT, Provencher S, Bonnet S, Leite-Moreira AF, Brás-Silva C. Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension. ERS (European Respiratory Society) International Congress 2018. Paris, França.
2018 - Current Pinto AR, Maia-Rocha C, Adão R, Mendes-Ferreira P, Salgado S, Miranda I, Leite-Moreira AF, Brás-Silva C. Expression of Glycolysis genes in Pulmonary Arterial Hypertension – Effects of chronic treatment with NRG-1. 13th YES - Young European Scientist - Meeting – 2018. Porto, Portugal.
2018 - Current Pimentel LD, Mendes- Ferreira P, Santos-Ribeiro D, Adão R, Maia-Rocha C, Monteiro- Pinto C, Provencher S, Bonnet S, Leite-Moreira AF, Brás-Silva C. MicroRNA-146a role in the pathophysiology of pulmonary arterial hypertension. 13th YES - Young European Scientist - Meeting – 2018. Porto, Portugal.
2018 - Current Adão R, Pimentel LD, Mendes-Ferreira P, Maia-Rocha C, Monteiro-Pinto C, Leite-Moreira AF; Brás-Silva C. Urocortin-2 improves pulmonary endothelial function in experimental pulmonary arterial hypertension. Congresso Português de Cardiologia 2018; Albufeira, Portugal.
2018 - Current Pinto AR, Maia-Rocha C, Adão R, Mendes-Ferreira P, Salgado S, Miranda I, Leite-Moreira AF, Brás-Silva C. Expression of GLUT1 and GLUT4 in right ventricle in Pulmonary Arterial Hypertension – Effects of chronic treatment with NRG1. VI AEICBAS Biomedical Congress. Porto, Portugal.
2017 - Current Pimentel L, Mendes-Ferreira P, Maia-Rocha C, Adão R, Santos-Ribeiro D, Salgado S, Pinto C, Potus F, Provencher S, Bonnet S, Leite-Moreira AF, Brás-Silva C. O papel do MicroRNA-146a na hipertensão arterial pulmonar. Congresso Português de Cardiologia 2017. Albufeira, Portugal.
2017 - Current Monteiro-Pinto C, Adão R, Mendes-Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Pimentel LD, Leite-Moreira AF, Brás-Silva C. Urocortin-2 attenuates experimental pulmonary arterial hypertension and right ventricular dysfunction. IJUP’ 17 – 10th Meeting of Young Researchers of University of Porto. Porto, Portugal.
2017 - Current Maia-Rocha C, Adão R, Mendes-Ferreira P, Leite-Moreira AF, Brás-Silva C. Expression of GLUT1 and GLUT4 in right ventricle in Pulmonary Arterial Hypertension – Effects of chronic treatment with NRG1. 9º Simpósio de Metabolismo. Porto, Portugal.
2017 - Current Pinto C, Adão R, Mendes-Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Pimentel L, Salgado S, Potus F, Rademaker MT, Bonnet S, Leite-Moreira AF, Brás-Silva C. Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension. Congresso Português de Cardiologia 2017. Albufeira, Portugal.
2017 - Current Maia-Rocha C, Adão R, Mendes-Ferreira P, Salgado S, Leite-Moreira AF, Brás-Silva C. Efeito do tratamento crónico com neuregulina-1 na expressão génica dos transportadores da glucose na hipertensão arterial pulmonar. Congresso Português de Cardiologia 2017. Albufeira, Portugal.
2017 - Current Salgado S, Adão R, Maia-Rocha C, Mendes-Ferreira P, Pinto C, Pimentel L, Falcão-Pires I, Leite-Moreira AF, Brás-Silva C. Modulação da função diastólica do ventrículo direito pela neuregulina-1 na hipertensão arterial pulmonar. Congresso Português de Cardiologia 2017. Albufeira, Portugal.
2016 - Current Adão R, Mendes-Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Pinto C, Pimentel L, Potus F, Breuils-Bonnet S, Rademaker M, Provencher S, Bonnet S, Leite-Moreira AF, Brás-Silva C. Urocortin-2 attenuates pulmonary arterial hypertension. 13th International Medical postgraduate conference – new frontiers in the research of Ph.D. students; Hradec Králové, República Checa.
2016 - Current Pimentel LD, Mendes-Ferreira P, Potus F, Santos-Ribeiro D, Maia-Rocha C, Adão R, Monteiro-Pinto C, Leite-Moreira AF, Bonnet S, Brás-Silva C. MicroRNA-146a expression is increased in human PAH.Yes meeting 2016; Porto, Portugal.
2016 - Current Mendes-Ferreira P, Potus F, Santos-Ribeiro D, Maia-Rocha C, Adão R, Leite-Moreira AF, Provencher S, Bonnet S, Brás-Silva C. MicroRNA-146a expression is increased in human PAH. Congresso Português de Cardiologia – CPC 2016. Vilamoura, Portugal.
2016 - Current Mendes- Ferreira M, Adão R, Mendes-Ferreira P, Santos-Ribeiro D, Maia-Rocha C, Leite-Moreira AF, Brás-Silva C. Urocortin-2 Improves Right Ventricular Function in Pulmonary Arterial Hypertension. IJUP’16. Porto, Portugal.
2016 - Current Adão R, Mendes-Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Pinto C, Pimentel L, Potus F, Breuils-Bonnet S, Provencher S, Bonnet S, Leite-Moreira AF, Brás-Silva C. A urocortina-2 atenua a disfunção ventricular direita e a hipertensão arterial pulmonar. XXXII Congresso de Pneumologia; Algarve, Portugal.
2016 - Current Mendes-Ferreira P, Santos-Ribeiro D, Maia-Rocha C, Adão R, Pimentel L, Pinto, C, Potus F, Leite-Moreira AF, Provencher S, Bonnet S, Brás-Silva C. O papel do MicroRNA-146a na hipertensão arterial pulmonar. XXXII Congresso de Pneumologia; Algarve, Portugal.
2016 - Current Monteiro-Pinto C, Adão R, Mendes- Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Pimentel LD, Leite-Moreira AF; Brás-Silva, C. Urocortin-2 improves right ventricular function and attenuates experimental pulmonary arterial hypertension. Yes meeting 2016; Porto, Portugal.
2016 - Current Adão R, Mendes-Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Potus F, Breuils-Bonnet S, Provencher S, Bonnet S, Rademaker MT, Leite-Moreira AF, Brás-Silva C. Urocortin-2treatment reduces right ventricular dysfunction in pulmonary arterial hypertension. ESC Congress 2016, Rome, Italy.
2016 - Current Maia-Rocha C, Adao R, Mendes-Ferreira P, Santos-Ribeiro D, Rademaker M, Leite-Moreira AF, Brás-Silva C. The right ventricle molecular changes associated with pulmonary arterial hypertension are attenuated by Urocortin 2 Treatment. ESC Congress 2016; Rome, Italy.
2016 - Current Adao R, Mendes-Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Potus F, Breuils-Bonnet S, Provencher S, Bonnet S, Rademaker M, Leite-Moreira AF, Brás-Silva C. Urocortin-2 improves right ventricular function and attenuates experimental pulmonary arterial hypertension. Frontiers in CardioVascular Biology 2016; Florence, Italy
2016 - Current Maia-Rocha C, Adao R, Mendes-Ferreira P, Santos-Ribeiro D, Rademaker M, Leite-Moreira AF, Brás-Silva C. Molecular Mechanisms underlying the beneficial effects of Urocortin 2 in pulmonary arterial hypertension. Frontiers in CardioVascular Biology 2016; Florence, Italy.
2016 - Current Adão R, Mendes-Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Potus F, Breuils-Bonnet S, Provencher S, Bonnet S, Leite-Moreira AF, Brás-Silva C. Urocortin-2 attenuates right ventricular dysfunction in pulmonary arterial hypertension. Heart Failure 2016 Conference. Florence, Italy.
2016 - Current Maia-Rocha C, Adao R, Mendes-Ferreira P, Santos-Ribeiro D, Rademaker M, Leite-Moreira AF, Brás-Silva, C. The right ventricle molecular changes associated with pulmonary arterial hypertension are attenuated by Urocortin-2 treatment. Heart Failure 2016 Conference; Florence, Italy.
2016 - Current Mendes-Ferreira P, Santos-Ribeiro D, Adao R, Maia-Rocha C, Mendes-Ferreira M, Sousa-Mendes C, Leite-Moreira AF, Brás-Silva C. Pulmonary artery banding-induced adaptive and maladaptive remodelling of the right ventricle in the rat. Heart Failure 2016 Conference; Florence, Italy.
2016 - Current Adão R, Mendes-Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Pinto C, Pimentel L, Potus F, Breuils-Bonnet S, Provencher S, Bonnet S, Leite-Moreira AF, Brás-Silva C. Urocortin-2 Improves Right Ventricular Function in Pulmonary Arterial Hypertension. American Thoracic Society 2016 International Conference; San Francisco, USA.
2016 - Current Mendes-Ferreira P, Potus F, Santos-Ribeiro D, Maia-Rocha C, Adão R, Leite-Moreira AF, Provencher S, Bonnet S, Brás-Silva C. MicroRNA-146a Expression Is Increased in Human PAH. American Thoracic Society 2016 International Conference. San Francisco, USA.
2016 - Current Maia-Rocha C, Adão R, Mendes-Ferreira P, Santos-Ribeiro D, Leite-Moreira AF, Brás-Silva C. Alterações moleculares subjacentes aos efeitos benéficos da urocortina2 na hipertensão arterial pulmonar. Congresso Português de Cardiologia – CPC 2016. Vilamoura, Portugal.
2016 - Current Adão R, Mendes-Ferreira P, Maia-Rocha C, Santos-Ribeiro D, Potus F, Breuils-Bonnet S, Provencher S, Bonnet S, Leite-Moreira AF, Brás-Silva C. Urocortin-2 attenuates right ventricular dysfunction in pulmonary arterial hypertension. Congresso Português de Cardiologia – CPC 2016. Vilamoura, Portugal.
2016 - Current Adão R, Santos-Ribeiro D, Mendes-Ferreira P, Maia-Rocha C, Rademaker M, Leite-Moreira AF, Brás-Silva C. Urocortin-2 improves right ventricular function in pulmonary and attenuates experimental pulmonar arterial hypertension. 5º Encontro de Doutorandos da Faculdade de Medicina da Universidade do Porto – 5º ED-FMUP. Porto, Portugal.
2015 - Current Adão R, Santos- Ribeiro D, Mendes-Ferreira P, Maia-Rocha C, Alves BS, Leite-Moreira AF, Brás-Silva C. Urocortin2 improves right ventricular function in pulmonary arterial hypertension. European Congress of Cardiology. Londres. Reino Unido.
2015 - Current Santos-Ribeiro D, Adão R, Mendes-Ferreira P, Maia-Rocia C, Alves BS, Leite-Moreira AF, Brás-Silva C. Urocortin-2 improves right ventricular function in pulmonary arterial hypertension. XXXVI Congresso Português de Cardiologia. Albufeira, Portugal.
2015 - Current Santos-Ribeiro D, Mendes-Ferreira P, Adão R, Maia-Rocha C, Alves BS, Rademaker M, Leite-Moreira AF, Brás-Silva C. Urocortin-2 improves right ventricular function in pulmonary arterial hypertension. Heart Failure 2015. Sevilha, Spain.
2015 - Current Mendes-Ferreira P, Adao R, Maia-Rocha C, Alves BS, Santos-Ribeiro D, Hamdani N, Linke WA, De Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Neuregulin-1 improves right ventricular function and attenuates monocrotaline-induced pulmonary arterial hypertension. Heart Failure 2015. Sevilha, Spain.
2015 - Current Mendes­-Ferreira P, Adão R, Maia-­Rocha C, Santos-­Ribeiro D, Alves BS, De Keulenaer GW, Leite ­Moreira AF, Brás­Silva C. Neuregulin­1 improves right ventricular function and attenuates monocrotaline­induced pulmonary arterial hypertension. Heart Failure Association Winter Research Meeting 2015. Les Diablerets, Switzerland
2015 - Current Santos-­Ribeiro D, Mendes­-Ferreira P, Adão R, Maia-­Rocha C, Alves BS, Rademaker M, Leite Moreira AF, Brás ­Silva C. Urocortin­2 improves right ventricular function in pulmonary arterial hypertension. Heart Failure Association Winter Research Meeting 2015 January. Les Diablerets, Switzerland
2015 - Current Adao R, Mendes-Ferreira P, Maia-Rocha C, Alves BS, Santos-Ribeiro D, Falcao-Pires I, De Keulenaer GW, Leite-Moreira AF, Bras-Silva C. A Neuregulina-1 modula a função dos cardiomiócitos do ventrículo direito na hipertensão arterial pulmonar. XXXV Congresso Português de Cardiologia, Albufeira, Portugal.
2014 - Current Mendes-Ferreira P, Ribeiro D, Alves B, Adão R, Maia-Rocha C, de Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Reversão da hipertrofia ventricular direita pela neuregulina-1. XXXV Congresso Português de Cardiologia
2014 - Current Maia-Rocha C, Mendes-Ferreira P, Adão R, Santos-Ribeiro D, Alves BS, De Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Molecular mechanisms underlying the beneficial effects of neuregulin-1 in pulmonary arterial hypertension. Frontiers in Cardiovascular Biology 2014. Barcelona, Spain.
2014 - Current Adao R, Mendes-Ferreira P, Hamdani N, Maia-Rocha C, Mendes MJ, Falcao-Pires I, de Keulenaer GW, Linke W, Leite-Moreira AF, Bras-Silva C. Neuregulin-1 ameliorates right ventricular diastolic dysfunction in pulmonary arterial hypertension. Frontiers in Cardiovascular Biology 2014. Barcelona, Spain.
2014 - Current Maia-Rocha C, Mendes-Ferreira P, Adao R, Santos-Ribeiro D, Alves BS,. De Keulenaer GW,. Leite-Moreira AF, Bras-Silva C. The right ventricle molecular changes associated with pulmonary arterial hypertension are attenuated by neuregulin-1 treatment. European Society of Cardiology Congress 2014. Barcelona, Spain.
2014 - Current Adao R, Mendes-Ferreira P, Hamdani N, Maia-Rocha C, Mendes MJ, Falcao-Pires I, De Keulenaer GW, Linke W, Leite-Moreira AL, Bras-Silva C. Neuregulin-1 preserves right ventricular diastolic function in animal model of pulmonary arterial hypertension. European Society of Cardiology Congress 2014. Barcelona, Spain.
2014 - Current Santos-Ribeiro D, Adão R, Maia-Rocha C, Alves B, Mendes-Ferreira P, Leite-Moreira AF, Brás-Silva C. Urocortin-2 Improves Right Ventricular Function In Pulmonary Arterial Hypertension. American Heart Association, Scientific Sessions 2014. Chicago, United States of America.
2014 - Current Mendes-Ferreira P, Adão R, Maia-Rocha C, Santos-Ribeiro D, Alves BS, De Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Neuregulin-1 improves right ventricular function and attenuates monocrotaline-induced pulmonary arterial hypertension. Heart Without Borders – Cardiovascular Development, Disease and Repair – International Conference. Porto, Portugal.
2014 - Current Santos-Ribeiro D, Mendes-Ferreira P, Adão R, Maia-Rocha C, Alves BS, Leite-Moreira AF, Brás-Silva C. Urocortin-2 improves right ventricular function in pulmonar arterial hypertension. Heart Without Borders – Cardiovascular Development, Disease and Repair – International Conference 2014. Porto, Portugal.
2014 - Current Alves BS, Santos-Ribeiro D, Adão R, Maia-Rocha C,Mendes-Ferreira P, Leite-Moreira A, Brás-Silva C. Modulation of right ventricle function by Neuregulin-1 therapeutic implications in pulmonary hypertension. IJUP’ 14 – 7th Meeting of Young Researchers of University of Porto, 2014, Porto, Portugal.
2014 - Current Santos-Ribeiro D, Mendes-Ferreira P, Alves BS, Adão R, Maia-Rocha C, Leite-Moreira A, Brás-Silva C. Molecular mechanisms underlying the beneficial effect of Neuregulin-1 in the treatment of Pulmonary Arterial Hypertension. IJUP’ 14 – 7th Meeting of Young Researchers of University of Porto. 2014, Porto, Portugal.
2014 - Current Mendes-Ferreira P, Santos-Ribeiro D, Alves BS, Adao R, Maia-Rocha C, Leite-Moreira AF, De Keulenaer GW, Bras-Silva C. Neuregulin-1 attenuates right ventricle hypertrophy in a model of pulmonary artery banding. Heart Failure Congress 2014, Athens, Greece.
2014 - Current Adão R, Alves BS, Santos-Ribeiro D, Maia-Rocha C, Handani N, Mendes- Ferreira P, Falcão-Pires I., De Keulenaer GW, Linke W, Leite-Moreira AF, Brás-Silva C. Neuregulin-1 preserves right ventricular diastolic function in na animal modelo f pulmonar arterial hypertension. 9th YES - Young European Scientist - Meeting -2014. Porto, Portugal.
2013 - Current Adão R, Meireles A, Mendes-Ferreira P, Maia-Rocha C, Falcão-Pires I, de Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Neuregulin-1 decreases the passive force of cardiomyocytes from the right ventricle in pulmonary arterial hypertension. IJUP’ 13 – 6th meeting of young researchers at University of Porto. Porto, Portugal.
2013 - Current Mendes-Ferreira P, Maia-Rocha C, Adão R, Cerqueira RJ, Mendes MJ, Lourenço AP, De Keulenaer GW, Leite-Moreira AF, Bras-Silva C. Neuregulin Attenuates Right Ventricular and Pulmonary Endothelial Dysfunction in an Experimental Model of Pulmonary Hypertension. World Symposium on Pulmonary Hypertension. Nice, France
2013 - Current Mendes-Ferreira P, Adão R, Maia-Rocha C, Lourenco AP, Meireles A, Falcao-Pires I, de Keulenaer GW, Leite-Moreira AF, Bras-Silva C. Neuregulin-1 treatment reduces right ventricular dysfunction in pulmonary arterial Hypertension. Heart Failure 2013, Lisbon, Portugal.
2013 - Current Adão R, Meireles A, Mendes-Ferreira P, Maia-Rocha C, Falcão-Pires , de Keulenaer G W,Leite-Moreira AF, Brás-Silva C. Neuregulin-1 modulates right ventricle cardiomyocyte function in pulmonary arterial hypertension. European Society of Cardiology Congress 2013. Amsterdam, Netherlands.
2013 - Current Adão R, Meireles A, Mendes-Ferreira P, Maia-RochaC, Falcão-Pires I, de Keulenaer GW, Leite-Moreira AF and Brás-Silva C. Neuregulin-1 Chronic Treatment Improves Right Ventricle Cardiomyocyte Function in Pulmonary Hypertension. American Heart Association Scientific Sessions 2013. Dallas, USA
2013 - Current Mendes-Ferreira P, Maia-Rocha C, Adão R, Lourenço A, Cerqueira R, Pinho S, Mendes M, Castro-Chaves P, de Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Neuregulin-1 treatment reduces the severity of pulmonary arterial hypertension. IJUP’ 13- 6th Meeting of young researchers of University of Porto. Porto, Portugal.
2012 - Current Adão R, Maia-Rocha C, Mendes-Ferreira P, Mendes MJ, Cerqueira RJ, Castro-Chaves P, De Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Neuregulin attenuates pulmonary endothelial dysfunction in an experimental model of pulmonary hypertension. IJUP’12 – 5th meeting of young researchers at university of Porto. Porto, Portugal.
2012 - Current Mendes-Ferreira P, Maia-Rocha C, Adão R, Lourenco AP, Cerqueira RJ, Mendes MJ, Castro-Chaves P, De Keulenaer GW, Leite-Moreira AF, Bras-Silva C. Neuregulin attenuates right ventricular hypertrophy and dysfunction in an experimental model of pulmonary hypertension. Frontiers in Cardio Vascular Biologia, 2nd Meeting. London.
2012 - Current Mendes-Ferreira P, Maia-Rocha C, Adão R, Cerqueira RJ, Mendes MJ, Lourenço AP, Pinho S, De Keulenaer GW, Leite-Moreira A, Bras-Silva C. NRG-1 improves monocrotaline-induced right ventricular and pulmonary endothelial dysfunction. Heart Failure 2012. Belgrade, Serbia.
2012 - Current Vidal-Meireles AM, Mendes-Ferreira P, Adão R, Maia-Rocha C, Cerqueira RJ, Mendes MJ, Castro-Chaves P, De Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Neuregulin attenuates pulmonary endothelial dysfunction in pulmonary hypertension. 7th Yes Meeting 2012, Porto, Portugal.
2012 - Current Mendes-Ferreira P, Maia-Rocha C, Adão R, Cerqueira RJ, Mendes MJ, Lourenço AP, De Keulenaer GW, Leite-Moreira AF, Bras-Silva C. Neuregulin Attenuates Right Ventricular and Pulmonary Endothelial Dysfunction in an Experimental Model of Pulmonary Hypertension. American Heart Association, Scientific Sessions 2012. Los Angeles, California, USA
2012 - Current Mendes-Ferreira P, Maia-Rocha C, Adao R, Lourenço AP, Moura C, Mendes MJ, Pinho S, Areias JC, De Keulenaer GW, Leite-Moreira AF, Brás-Silva C. A neuregulina atenua a hipertrofia e a disfunção ventricular direitas num modelo experimental de hipertensão pulmonar. XXXIII Congresso Português de Cardiologia. Vilamoura, Portugal.
2012 - Current Mendes-Ferreira P, Adao R, Cerqueira R, Maia-Rocha C, Mendes MJ, Castro-Chaves P, Leite-Moreira A, Brás-Silva C. A Neuregulina 1 atenua a disfunção endotelial na hipertensão arterial pulmonar. XXXIII Congresso Português de Cardiologia, Vilamoura, Portugal.
2012 - Current Maia-Rocha C, Adao R, Mendes-Ferreira P, Mendes MJ, Pinho S. Lourenço AP, De Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Neuregulin attenuates right ventricular hypertophy and dysfunction in a experimental model of pulmonar hypertension. IJUP’12 – 5th meeting of young researchers at university of Porto. Porto, Portugal.
2012 - Current Mendes-Ferreira P, Maia-Rocha C, Adao R, Lourenco AP, Moura C, Pinho S, Areias JC, De Keulenaer GW, Leite-Moreira AF, Bras-Silva C. NRG-1 improves right ventricular function in pulmonary hypertension. European Congress of Cardiology. Munich. Germany
2012 - Current Mendes-Ferreira P, Adao R, Maia-Rocha C, Cerqueira RJ, Mendes MJ, Castro-Chaves P, De Keulenaer GW, Leite-Moreira AF, Bras-Silva C. Neuregulin attenuates pulmonary endothelial dysfunction in pulmonary hypertension. European Congress of Cardiology. Munich. Germany.
2011 - Current Mendes-Ferreira P, Maia-Rocha C, Adão R, Silva M, Lourenço AP, Leite-Moreira AF, Brás-Silva C. Neuregulin attenuates right ventricular hypertrophy and dysfunction in an experimental model of pulmonary hypertension. IJUP’ 11 – 4th meeting of young researchers at university of Porto. Porto, Portugal.
2011 - Current Carmen Brás Silva, Ana Patrícia Fontes de Sousa, Mónica Almeida, Sónia Pinho, Cláudia Moura, Ana Pires, José Carlos Areias (Pedro Mendes Ferreira, Carolina Maia Rocha, Rui Adão, Maria Silva, Maria José Mendes, André Lourenço, Adelino Leite Moreira). Bolsa de Estudo João Porto - O papel do sistema da neuregulina na fisiopatologia da hipertensão pulmonar e na progressão para a insuficiência cardíaca. XXXII Congresso Português de Cardiologia. Lisbon, Portugal.
2011 - Current Maia-Rocha C, Mendes-Ferreira P, Adão R, Lourenço AP, Leite-Moreira AF, Brás-Silva C. Neuregulin increased expression and its modulation by bosentan in pulmonary hypertension. IJUP’ 11 – 4th meeting of young researchers at university of Porto. Porto, Portugal.
2011 - Current Brás-Silva C, Maia-Rocha C, Mendes-Ferreira P, Adão R, Lourenço AP, Leite-Moreira AF. Aumento da expressão génica de neuregulina e sua modulação pelo bosentan na hipertensão pulmonar. XXXII Congresso Português de Cardiologia. Lisboa, Portugal.
2011 - Current Mendes-Ferreira P, Maia-Rocha C, Adão R, Silva M, Mendes MJ, Lourenço AP, Cerqueira RJ, Castro-Chaves P, De Keulenaer GW, Leite-Moreira AF, Brás-Silva C. Neuregulin attenuates right ventricular hypertrophy and dysfunction in an experimental model of pulmonary hypertension. Yes meeting´11 - 6th young european scientist meeting. Porto, Portugal.
2010 - Current Comunicação oral efectuada no X Congresso de Geoquímica dos Países de Língua Portuguesa / XVI Semana de Geoquímica: Título - "Avaliação do risco potencial de exposição da população do Centro de Portugal ao chumbo ambiental, expresso nos solos da região" Autores - Adão, R.; Martins, H.; Patinha, C.; Reis, A.P.; C.Dias, A; Cachada A. P.;, Ferreira da Silva, E.; A. J. Sousa

Association member

Society Organization name Role
2015 - Current Sociedade Portuguesa de Pneumologia
2014 - Current European Society of Cardiology
2014 - Current European Respiratory Society
2013 - Current Sociedade Portuguesa de Cardiologia

Committee member

Activity description
Role 		Institution / Organization
2020 - Current Elected member of the Scientists of Tomorrow (SoT) Nucleus from European Society of Cardiology
2018 - Current Member of the European Society of Cardiology (ESC) - working groups on Myocardial Function and Pulmonary Circulation & Right Ventricular Function Membership
2015 - 2015 Cardiology Basic Science Summer School-2015. Nice, France
Member

Conference scientific committee

Conference name Conference host
2021/08 - Current Invited Chair for a session in European Society of Cardiology 2021 Congress
2020 - Current Invited Chair for a session in Frontiers in CardioVascular Biomedicine 2020 Congress (FCVB)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2014 - Current Teaching assistant in the Master Programme in Cardiovascular Pathophysiology and PhD programme in Cardiovascular Sciences at the Faculty of Medicine, University of Porto

Journal scientific committee

Journal title (ISSN) Publisher
2022/02/02 - Current Frontiers of Cardiovascular Medicine
2021/02/03 - Current Frontiers in Pharmacology FRONTIERS RESEARCH FOUNDATION
2020/06/03 - Current Cardiovascular Research Oxford University Press
2020/04/01 - Current Journal of Visualized Experiments MyJove Corp.
2020/03/03 - Current Revista Portuguesa de Cardiologia (0870-2551) Elsevier

Mentoring / Tutoring

Topic Student name
2023 - Current Supervisor of the thesis "Cardiovascular Effects of Relaxin-2: Therapeutic Potential and Future Perspectives"(Curricular Master Thesis - Medicine, Faculty of Medicine of University of Porto) Nísia Almeida Pinto
2021 - Current Co-supervisor of the thesis "Role of Ucn2 in Heart Failure with Preserved Ejection Fraction" (PhD thesis in Cardiovascular Sciences - Faculty of Medicine of University of Porto) Inês Vasconcelos
2020 - Current Co-supervisor of the thesis "Insight in the pathophysiological role of Mir-146a in Pulmonary Arterial hypertension - Therapeutic implications" (PhD thesis in Cardiovascular Sciences - Faculty of Medicine of University of Porto) Joana Gomes
2021 - 2022 Supervisor of the thesis "Pulmonary valve replacement: a new paradigm with tissue engineering"(Curricular Master Thesis - Medicine, Faculty of Medicine of University of Porto) Ruben Almeida Pinto
2020 - 2022 Co-supervisor of the thesis "Novel therapeutic approaches in Heart Failure with Preserved Ejection Fraction" (Curricular Master Thesis - Medicine, Faculty of Medicine of University of Porto) Pedro Vaz Salvador
2020 - 2022 Co-supervisor of the thesis "Does Urocortin-2 induce changes in neurogenesis and in the GABAergic system of the hippocampal formation of rats with HFpEF?" (Curricular Master Thesis - Medicine, Faculty of Medicine of University of Porto) Débora Costa
2020 - 2022 Co-supervisor of the thesis "Insight in the pathophysiological role of Mir-146a in Pulmonary Arterial hypertension" (Master thesis in Cardiovascular Pathophysiology - Faculty of Medicine of University of Porto) Beatriz Silva Rego
2020 - 2022 Co-supervisor of the thesis "Role of Ucn2 in Heart Failure with Preserved Ejection Fraction" (Master Thesis in Biochemistry - Institute of Biomedical Sciences Abel Salazar, University of Porto ) Inês Vasconcelos
2019 - 2020 Co-supervisor of the thesis; “Persistent Pulmonary Hypertension of the Newborn: Pathophysiological mechanisms and novel therapeutic approaches” (Curricular Master Thesis - Medicine, Faculty of Medicine of University of Porto) Sofia Martinho
2018 - 2020 Co-supervisor of the thesis "MicroRNAs as Prognostic Biomarkers in Heart Failure" (Master thesis in Cardiovascular Physiopathology - Faculty of Medicine of University of Porto) Ana Rita Figueiredo
2018 - 2019 Co-supervisor of the thesis; “Effects of Urocortin-2: Pathophysiological mechanisms and Therapeutic Potential” (Curricular Master Thesis - Medicine, Faculty of Medicine of University of Porto) Cláudia Monteiro Pinto
2017 - 2018 Co-supervisor of the Master thesis; “Neuregulin-1 effects in metabolic changes induced by Pulmonary Arterial Hypertension” (Master Degree in Molecular and Cellular Biology, University of Aveiro) Ana Rita Pinto
2017 - 2017 Co-supervisor of the Master thesis; “The role of Ucn-2 on doxorubicin-induced cardiomyopathy” (Master Degree in Drug Development, University of Antwerp). Raphaelle Corremans
2015 - 2016 Co-supervisor of the Master thesis; “Neuregulin-1 effects in metabolic changes induced by Pulmonary Arterial Hypertension” (Master Degree in Molecular and Cellular Biology, University of Aveiro) Stephanie Salgado
2013 - 2014 Co-supervisor of the Master thesis; “The role of urocortin-2 in Pulmonary Arterial Hypertension” (Master Degree in Molecular and Cellular Biology, University of Aveiro) Diana Santos Ribeiro
2012 - 2014 Co-supervisor of the Master thesis; “Modulation of right ventricle function by neuregulin-1” (Master Degree in Cardiovascular Pathophysiology, University of Porto) Bárbara Silva
2012 - 2013 Co-supervisor of the Master thesis: “ErbB receptor stimulation – a therapeutic approach in pulmonary hypertension” (Master Degree in Molecular Biotechnology, University of Porto) André Meireles
Distinctions

Award

2020 Travel Grant for Frontiers in CardioVascular Biomedicine 2020 Congress (FCVB), Budapest- Title of abstract: "Urocortin-2 modulates altered myofilament calcium sensitivity in right heart failure induced by pulmonary arterial hypertension"
Société Européenne de Cardiologie, France
2020 Best Young Basic Researcher
Sociedade Portuguesa de Cardiologia, Portugal
2019 Merit Scholarship – Best student of Faculty of Medicine of University of Porto (2012/2013 school year)
Universidade do Porto, Portugal
2018 “Bolsa de Estudo João Porto” - Title: “Role of Urocortin-2 in Heart Failure with Preserved Ejection Fraction - pathophysiological and therapeutic implications”
Sociedade Portuguesa de Cardiologia, Portugal
2018 1º Award Thomé Villar/Boehringer Ingelheim, para o trabalho for the study: “Acute and chronic effects of urocortin-2 therapy on intracellular Ca2+ homeostasis in right heart failure induced by pulmonary arterial hypertension”
Sociedade Portuguesa de Pneumologia, Portugal
2018 Honorable mention – 2ª Edition of Janssen Inovation Award, ao trabalho "Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension"
2018 Travel Grant for ERS Congress 2018, Title of abstracts: "Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension " & "Role of Urocortin-2 in Ca2+ Handling Dysfunction in Right Ventricle Failure
European Respiratory Society, Switzerland
2017 Servier award in Heart Failure – Basic Science - 2016/17- “Papel do MicroRNA-146a na hipertensão arterial pulmonar e na disfunção ventricular direita”
Sociedade Portuguesa de Cardiologia, Portugal
2017 European Respiratory Society - Short-Term Fellowship Grant ao estudo "Role of Urocortin-2 in Ca2+ Handling Dysfunction in Right Ventricle Failure Induced by Pulmonary Artery Hypertension"
European Respiratory Society, Switzerland
2016 Thomé Villar/Boehringer Ingelheim Award - Title: “Urocortin-2 attenuates Pulmonary Arterial Hypertension"
Sociedade Portuguesa de Cardiologia, Portugal
2016 Robalo Cordeiro Award – SPP/Novartis - Title: “MicroRNA-146a is implicated in the development of Pulmonary Hypertension – Human and experimental insights"
Sociedade Portuguesa de Pneumologia, Portugal
2016 Physiology & Immunology Poster Presentation First Prize 11th YES - Young European Scientist Meeting - Title: “Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension”
Universidade do Porto, Portugal
2016 Travel Grant for European Society of Cardiology Congress, London- Title of abstract: "Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension"
2015 Travel Grant for ESC Congress 2015, London - Title of abstract: "Urocortin-2 improves right ventricular function and attenuates pulmonary arterial hypertension "
Société Européenne de Cardiologie, France
2015 1º Award Thomé Villar/Boehringer Ingelheim - Title: “Neuregulin-1 improves right ventricular function and attenuates experimental pulmonar arterial hypertension”
Sociedade Portuguesa de Pneumologia, Portugal
2015 Robalo Cordeiro Award – SPP/Novartis - Title: “Pathophysiological role of mir-146a in pulmonary arterial hypertension – therapeutic implications”
Sociedade Portuguesa de Pneumologia, Portugal
2015 Servier award in Heart Failure – Basic Science - Title: “A Urocortina-2 Atenua a Hipertensão Arterial Pulmonar e a Disfunção Ventricular Direita num Modelo Experimental de Hipertensão Pulmonar”
Sociedade Portuguesa de Cardiologia, Portugal
2015 Best communication 4th Doctoral Meeting – FMUP - Title: “Urocortin-2 improves right ventricular function in pulmonary arterial hypertension”
Universidade do Porto Faculdade de Medicina, Portugal
2014 Prof. Ernesto Morais Award/9th YES - Young European Scientist Meeting - Title: “Neuregulin-1 preserves right ventricular diastolic function in an animal model pulmonar arterial hypertension”
Universidade do Porto, Portugal
2014 Molecular mechanisms underlying the beneficial effects of neuregulin­ 1 in pulmonary arterial hypertension ­ Physiology & Immunology Poster Presentation First Prize
2014 “Bolsa de Estudo João Porto” - Title: "O papel do miRNA­146a na hipertensão arterial pulmonar" ­
Sociedade Portuguesa de Cardiologia, Portugal
2014 Servier award in Heart Failure – Basic Science - Title: “A neuregulina-1 atenua a hipertensão arterial pulmonar e a disfunção ventricular direita num modelo experimental de hipertensão pulmonar"
Sociedade Portuguesa de Cardiologia, Portugal
2005 Rotary Best Student Award - best student in Santa Maria da Feira (2003/2004 school year)