Identification
Personal identification
- Full name
- Carla Manuela de Castro Abreu
Citation names
- Abreu, Carla M.
- Abreu, Carla M. C.
Author identifiers
- Ciência ID
- E218-D8D7-1EBA
- ORCID iD
- 0000-0002-8070-8388
- Scopus Author Id
- 37025489900
Addresses
- Institute for Research and Innovation in Health (i3S), Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)
Websites
- https://www.i3s.up.pt/personal-info.php?id=2482&idg=50 (Professional)
Knowledge fields
- Natural sciences - Biological Sciences - Cell Biology
- Natural sciences - Biological Sciences - Molecular Biology
- Natural sciences - Biological Sciences - Biochemistry
- Natural sciences - Biological Sciences - Genetics and Heredity
- Natural sciences - Biological Sciences - Developmental Biology
- Natural sciences - Biological Sciences - Reproductive Biology
- Natural sciences - Biological Sciences - Microbiology
- Medical and Health Sciences - Clinical Medicine - Oncology
- Medical and Health Sciences - Basic Medicine - Neurosciences
- Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
Languages
Language | Speaking | Reading | Writing | Listening | Peer-review |
---|---|---|---|---|---|
Portuguese (Mother tongue) | |||||
English | Proficiency (C2) | Proficiency (C2) | Proficiency (C2) | Proficiency (C2) | Proficiency (C2) |
Education
Degree | Classification | |
---|---|---|
2018/09
Concluded
|
Course in Laboratory Animal Science accredited by FELASA following the recommendations for Category C (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
|
2013/05/15 - 2018/06/21
Concluded
|
Postdoctoral Research Fellow in Prof. Maria Jasin Lab (Pós-doutoramento)
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, United States
|
|
2013/05 - 2018/05
Concluded
|
Animal handling courses and training by IACUC and RARC (Outros)
Memorial Sloan Kettering Cancer Center, United States
|
|
2008/01/01 - 2013/03/21
Concluded
|
PhD. student in Prof. Noel Lowndes Lab (Doutoramento)
Biochemistry and Cell Biology Program, National University of Ireland Galway, Ireland
"Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response" (THESIS/DISSERTATION)
|
|
2003/09/15 - 2007/12/20
Concluded
|
Applied Biology Degree (Graduated in the top 5) (Licenciatura)
Universidade do Minho, Portugal
|
16/20 |
2007/01/01 - 2007/07/31
Concluded
|
Undergraduate Final Year Project in Prof. Noel Lowndes Lab (Erasmus Program) (Licenciatura)
National University of Ireland Galway School of Natural Sciences, Ireland
"Structure-Function analysis of the Saccharomyces cerevisiae Mec1, homolog of the human cell cycle master regulator ATR" (THESIS/DISSERTATION)
|
19/20 |
2005/07/11 - 2005/07/29
Concluded
|
Undergraduate Summer Project in Prof. Isabel Mina lab (Outros)
Universidade do Minho Departamento de Biologia, Portugal
|
Affiliation
Science
Category Host institution |
Employer | |
---|---|---|
2020 - Current | Auxiliary Researcher (Research) | Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal |
2018/09/01 - 2020 | Researcher (Research) | Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal |
2013/05/15 - 2018/06/21 | Postdoc (Research) | Memorial Sloan Kettering Cancer Center, United States |
2013/04/21 - 2013/05/04 | Visiting Researcher (Research) | Universitat Autònoma de Barcelona Facultat de Ciències, Spain |
Others
Category Host institution |
Employer | |
---|---|---|
2008/01/01 - 2013/03/21 | PhD. student | National University of Ireland Galway, Ireland |
Projects
Grant
Designation | Funders | |
---|---|---|
2023/01 - 2024/06 | Investigating the drivers of Fanconi Anemia-associated brain malformations
2022.01964.PTDC
Principal investigator
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2023/01 - 2024/06 | Dissecting the mechanisms regulating the essential roles of the Dynein-2 motor in cilia
2022.01955.PTDC
Collaborator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Ongoing
|
2018 - 2022/03/25 | Investigating the molecular causes of severe Microcephaly: Primary cilium dependent cell cycle control of neural stem cell
proliferation during brain development
POCI-01-0145-FEDER-029471
Integration into Research Grant Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
2014/05/01 - 2018/05 | Homology-directed DNA repair proteins BRCA2 and RAD51 in tumor relevant tissues
info:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/1R01CA185660-01/US
Post-doc
|
National Institutes of Health
Concluded
|
2015 - 2017 | Threshold effects and non-canonical functions of the tumor suppressor BRCA2 and interacting proteins RAD51 and DSS1
18-A8-104
Post-doc
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, United States
|
Concluded
|
2008/01/01 - 2013/03/21 | Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
SFRH/BD/42128/2007
PhD Student Fellow
Universidade do Minho Departamento de Biologia, Portugal
|
Fundação para a Ciência e a Tecnologia
Concluded
|
Outputs
Publications
Journal article |
|
Newsletter article |
|
Newspaper article |
|
Preprint |
|
Thesis / Dissertation |
|
Working paper |
|
Other
Other output |
|
Activities
Oral presentation
Presentation title | Event name Host (Event location) |
|
---|---|---|
2022/10/05 | Why are some organs more susceptible to cancer than others? | 5ª edition of the Pint of Science Festival (Portugal); https://www.pintofscience.pt/oradores
Pint of Science (Guimarães, Portugal)
|
2018/11/01 | DNA repair mechanisms required for meiotic progression involving SWS1-SWSAP1 and BRCA2 | Invited seminar and 2-day visit
Wellcome Centre for Human Genetics , University of Oxford (Oxford, United Kingdom)
|
2018/09/26 | DNA Repair Mechanisms Required For Meiotic Progression | Invited Seminar
Institute for Research and Innovation in Health (i3S) (Porto, Portugal)
|
2017/10/02 | The Mouse Shu Complex SWS1-SWSAP1 is Essential for Meiotic Recombination | The New York Academy of Science - Genome Integrity Discussion Group
The New York Academy of Sciences (New York, United States)
|
2017/08/31 | The mouse Shu complex SWS1-SWSAP1 is essential for meiotic recombination | EMBO Conference on Meiosis 2017
European Molecular Biology Organization (EMBO) (Hvar, Croatia)
|
2016/06/26 | Genetic Interaction Between BRCA2 C-Terminus and RAD54 During Germ Cell Development | 2016 Gordon Research Seminar on Meiosis - Mechanisms of Sexual Reproduction Through Meiosis
Gordon Research Conferences (New Hampshire, United States)
|
2015/05 | Genetic Interaction Between BRCA2 C-Terminus and RAD54 During Germ Cell Development | Developmental Biology Colloquium
Memorial Sloan Kettering Cancer Center (New York, United States)
|
2009/10/17 | A novel regulation model for Saccharomyces cerevisiae Mec1, homologue of ATR kinase | Irish Radiation Research Society Scientific Meeting 2009
Irish Radiation Research Society (Galway, Ireland)
|
2008/06/24 | A novel regulation model for Saccharomyces cerevisiae Mec1, homologue of ATR Kinase | 2nd EU-IP DNA Repair: Workshop for Young Scientists & Career Event
EU-IP (Porto, Portugal)
|
Supervision
Thesis Title Role |
Degree Subject (Type) Institution / Organization |
|
---|---|---|
2023/12 - Current | Dissecting the mechanisms mediating Dynein-2 incorporation into cilia and their implications for ciliopathies (PhD scholarship
awarded by FCT: 2023.01378.BD)
Supervisor of Maria João De-Castro
|
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2023/09 - Current | Studying ciliary dynamics upon loss of ciliopathy-associated genes
Supervisor of Maria João Monteiro
|
Engenharia Biomédica (Master)
Universidade do Minho, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal |
2022/01 - Current | Dissecting the mechanisms of ciliary gating: interplay between Dynein-2 and the transition zone (PhD scholarship awarded by
i3S/FCT: UI/BD/1528652022)
Co-supervisor of Ana R.G. De-Castro
|
PhD in Molecular and Cell Biology (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal |
2021/10 - Current | Dissecting the NDE1/LIS1-dependent regulation of Dynein-mediated transport in the brain (PhD scholarship awarded by FCT: 2021.04761.BD)
Co-supervisor of Tiago Xavier Ribeiro
|
PhD Biomedical Sciences (ICBAS, UP) (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal |
2019/11 - Current | Uncovering the mechanisms regulating the essential roles of Dynein-2 in cilia function (PhD scholarship awarded by FCT: SFRH/BD/143985/2019)
Co-supervisor of Diogo Rodrigues (PhD. student)
|
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2022/10 - 2023/12 | Investigating the drivers of Fanconi Anemia-associated brain malformations
Supervisor of Maria João De-Castro
|
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2023/02 - 2023/10 | Investigating a role for the IFT- A complex in the recruitment of molecular motors to neuronal cilia
Co-supervisor of Francisca Bryant-Jorge
|
Molecular Bioengineering (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2022/02 - 2023/10 | Recruitment and loading of Dynein-2 into cilia to ensure signaling functions
Co-supervisor of Luisa de Sousa Fonseca
|
Molecular Medicine and Oncology (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Faculdade de Medicina, Portugal |
2023/02 - 2023/08 | Dissecting the mechanisms regulating the essential roles of the Dynein-2 motor in cilia
Co-supervisor of Francisco Gonçalves Santos (currently a PhD student at Oxford University, UK)
|
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2022/09 - 2023/07 | Interplay between BRCA2 and the Spindle Assembly Checkpoint in Caenorhabditis elegans
Supervisor of Maria Francisca Sarmento Sousa
|
Biology (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal |
2021/09 - 2022/10 | Investigating the essential roles of BRCA2 during embryonic development in C. elegans (Master degree project; final score
20/20)
Supervisor of Maria João De-Castro (Master student)
|
Molecular Medicine and Oncology (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Faculdade de Medicina, Portugal |
2021/04 - 2022/10 | Investigating Dynein-2 regulation during intraflagellar transport in Cilia (Master degree project; final score 20/20)
Co-supervisor of Francisco Gonçalves Santos (prospect PhD student at Oxford University)
|
Molecular Medicine and Oncology (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Faculdade de Medicina, Portugal |
2022/09/01 - 2022/09/30 | BIIverao-i3S-18072207-2022: Investigating the contributions of BRCA2 for cell proliferation in Caenorhabditis elegans
Supervisor of Maria João De-Castro
|
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2020/10 - 2021/12 | The roles of IFT-20 in C. elegans cilia
Co-supervisor of Joana Quintas Gonçalves
|
Visiting researcher (Other)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2019/06 - 2020/12 | Ciliary recruitment of the dynein-2 motor and its role in C. elegans sensory functions (Master degree project; final score
20/20)
Co-supervisor of Ana R.G. De-Castro
|
MSc Program in Biomedical Sciences - Diseases Mechanisms (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal |
2020/05 - 2020/10 | Primary cilium-dependent cell cycle control of neural stem cell proliferation during brain development
Co-supervisor of José Costa Gama (Postdoc)
|
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2020/04 - 2020/10 | Investigating the cell dynamics of the essential tumour supressor BRCA2 during C. elegans development (bachelor's degree final
project; final score 19/20)
Supervisor of Ana R.G. De-Castro (final year's Bachelor degree student)
|
Ciências Biomédicas Laboratoriais (Degree)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Faculdade de Medicina, Portugal |
2020/01 - 2020/09 | Mechanisms governing Dynein-2 stability
Co-supervisor of Marcos Machado - volunteer student (currently a Master student at KTH, Stockholm, Sweden)
|
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
|
2018/03 - 2019/11 | Dissecting the molecular causes of NDE1-associated microcephaly (Master degree project; final score 19/20)
Co-supervisor of Carmen Leal Vieira (currently a Researcher at ICVS, Braga, Portugal)
|
Neurobiology (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Faculdade de Medicina, Portugal |
2010/01 - 2010/05 | Generation and characterisation of novel alleles of Mec1, the budding yeast homologue of human ATR
Co-supervisor of Clara Sanz Nogués (undergraduate Erasmus student)
|
National University of Ireland Galway School of Health Sciences, Ireland
Universitat de València, Spain |
2008/11 - 2008/12 | The analysis of the genetic dependency of Mec1 kinase phosphorylation
Co-supervisor of Paula Lee (undergraduate student)
|
National University of Ireland Galway School of Health Sciences, Ireland
|
Event organisation
Event name Type of event (Role) |
Institution / Organization | |
---|---|---|
2023/11 - 2023/11 | Organized and Spearheaded outreaching Lectures and Workshops integrated in the Projeto SEI (Sociedade, Escolas and Investigação)
to high school students of Agrupamento de Escolas Alexandre Herculano as part of National educational programs (2023/11/02 - 2023/11/23)
Workshop (Co-organisor)
|
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal Agrupamento de Escolas Alexandre Herculano, Portugal |
2023/03/13 - 2023/03/13 | Coordinator of outreach activities and workshops integrated into a scientific exhibition of the C. elegans nervous system
at i3S for secondary-school students (7th to 9th grade) as part of the International Brain Week 2023 and National Educational
Programs. (2023/03/13 - 2023/03/17)
Workshop (Member of the Organising Committee)
|
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal |
2017/06/09 - 2018/06/10 | 2018 Gordon Research Seminar - Mechanisms and Regulation of Gametogenesis Through Meiosis (https://www.grc.org/meiosis-grs-conference/2018/) (2018/06/09 - 2018/06/15)
Conference (Co-organisor)
|
Colby-Sawyer College, United States |
Jury of academic degree
Topic Role |
Candidate name (Type of degree) Institution / Organization |
|
---|---|---|
2023/11 | Unraveling how TLX3 antagonizes the action of LBX1 during the development of spinal glutamatergic neurons.
(Thesis) Main arguer
|
Diana Barcelos Carvalho (Master)
Universidade do Porto Faculdade de Medicina, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal |
2023/10 | The role of CD147 in tumor immunosuppression
(Thesis) Main arguer
|
Francisco José Ferreira Vilaça (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Escola de Ciências da Saúde, Portugal |
2023/10 | Effect of 3-Bromopyruvate in the response to chemotherapy in the in vivo chicken embryo model of Acute Myeloid Leukemia
(Thesis) Main arguer
|
Filipa Rodrigues Pimentel (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universidade do Minho Escola de Ciências da Saúde, Portugal |
2020/01/08 | Linking autophagy to feeding status: the function of egli-1 in the Caenorhabditis elegans nervous system
(Thesis) Main arguer
|
Jorge Diogo Cruz Ramos da Silva (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
|
Conference scientific committee
Conference name | Conference host | |
---|---|---|
2016/09/24 - 2016/09/25 | PAPS XVI forum “From 66 to 0 degrees of Separation: the Power of Networks” | Memorial Sloan Kettering Cancer Center, New York, USA |
2006/11 - 2006/11 | Member of the scientific organising committee of the VIII Conferences of Applied Biology | University of Minho, Braga, Portugal |
Course / Discipline taught
Academic session | Degree Subject (Type) | Institution / Organization | |
---|---|---|---|
2008/09 - 2012/06 | Instructor in pratical classes for undergraduates of Biochemistry and Cell Biology degree at National University of Ireland Galway | Biochemistry and Cell Biology (Bachelor) | National University of Ireland Galway College of Science, Ireland |
Journal scientific committee
Journal title (ISSN) | Publisher | |
---|---|---|
2020 - Current | Invited Reviewer for: Environmental and Molecular Mutagenesis | Wiley |
2020 - Current | Invited Reviewer for: Communications Biology | Nature Publishing Group |
Mentoring / Tutoring
Topic | Student name | |
---|---|---|
2015 - 2017 | Immunofluorescent imaging analyses | Undergraduate Students of Summer Programs at Memorial Sloan Kettering Cancer Center, NY, USA |
2012/01 - 2012/09 | Instructor of basic microbiology techniques in schools as part of the first volunteer group of the Cell EXPLORERS science education and outreach program (https://www.cellexplorers.com/). | Primary School students, in Ireland |
2011/10 - 2012/05 | Genetic analysis of ATR, a central regulator of genome stability | Marta Llorens Agost (PhD. student), Ireland |
2011 - 2011 | Instructor of basic scientific experiments to the general public in a science fair in Ireland with the purpose of a science education and outreach activity. | General Public, Galway Science & Technology Exhibition, Ireland |
Other jury / evaluation
Activity description | Institution / Organization | |
---|---|---|
2020/08 - 2020/10 | Jury of poster and oral presentations at the 3rd PhDay Meeting "Back to the Future", at the Institute of Investigation and Innovation in Health (i3S) in Porto | Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal |
Scientific expedition
Activity description | Institution / Organization | |
---|---|---|
2005/08/01 - 2005/08/15 | Summer Volunteer Project to study of stork migration | Colectivo Ornitológico Cigüeña Negra, Spain |
Distinctions
Award
2020 | 6-year FCT Scientific Employment Stimulus Grant (CEECIND/01985/2018)
Fundação para a Ciência e a Tecnologia, Portugal
|
2017 | Scholarship award to attend the FASEB Conference on Genetic Recombination and Genome Rearrangements
Federation of American Societies for Experimental Biology, United States
|
2015 | Scholarship award to attend the Ramon Areces Foundation International Symposium on "The biology of meiosis: implications for
fertility and genetic disorders"
Fundación Ramon Areces, Spain
|
2008 | 4-Year Doctoral fellowship award (SFRH/BD/42128/2007)
Fundação para a Ciência e a Tecnologia, Portugal
|
2007 | Erasmus scholarship award
European Commission, Belgium
|
Other distinction
2022 | Supervised work awarded as best oral presentation in 2 scientific meetings (IJUP and EUGLOH) |
2019 | (co-)Supervisor of 4 PhD students, all awarded with personal PhD scholarships |