???global.info.a_carregar???
Dr. Carla M. Abreu is an Assistant Investigator at the Instituto de Investigação e Inovação em Saúde (i3S), in Porto, Portugal, supported by an individual FCT award (CEECIND/01985/2018). Her professional journey includes a decade abroad, across four different countries (Ireland, Spain, USA, Portugal). During this period, she underwent advanced scientific training in animal development, cell/molecular biology, biochemistry, and genetics (in yeast, C. elegans, cell lines, and mouse models). Carla earned her PhD at the National University of Ireland Galway under the guidance of Prof. Lowndes, followed by a postdoc at the renowned Memorial Sloan Kettering Cancer Center, New York, in the lab of Prof. Jasin. During her postdoc, she also visited the lab of Prof. Roig in Barcelona to obtain specialized training in mouse models. In 2018, Carla transitioned to i3S, embarking on her independent research venture focused on exploring the interplay between cell proliferation signaling pathways and congenital diseases. Carla has published in esteemed international peer-reviewed journals, including Nature Comm. (as first author), Journal of Cell Biology, and Cell Reports (both of which as co-corresponding author). To date, Carla has a total of 8 publications, 2 as first-author and 4 as co-corresponding author. Her work has garnered 279 citations, establishing an i10-index of 5. Recognizing her expertise, Carla has been invited to present at numerous national and international meetings (10 oral communications). In addition to her research achievements, Carla has played pivotal roles in organizing scientific meetings, including her role as co-organizer for the prestigious Gordon Conference in Meiosis 2018, held in New London, USA. Throughout her illustrious career, she has secured individual funding (Erasmus and PhD fellowships, and a Scientific Employment Contract), and received travel awards to attend international meetings. Carla was the Principal Investigator of a Project Grant awarded by FCT (2022.01964.PTDC) and has actively contributed to several other projects funded by both national and international agencies. Carla's commitment to mentorship is evident through her supervision of 3 researchers, 1 postdoc, and 14 students at various educational levels, including undergraduates, Master's, and Ph.D. students. The success of her mentoring is reflected in the numerous awards and fellowships received by her students, as well as their subsequent enrollment in prestigious training programs, such as Master's and Ph.D. degrees at renowned institutions like Stockholm and Oxford Universities. Beyond her academic pursuits, Carla has engaged in many outreach activities and served as an external advisor in thesis defenses, showcasing her commitment to the broader scientific community. Her expertise is further acknowledged through invitations to review manuscripts for internationally acclaimed scientific journals. Overall, Carla stands as a distinguished scientist, mentor, and contributor to the advancement of knowledge in her field.
Identification

Personal identification

Full name
Carla Manuela de Castro Abreu

Citation names

  • Abreu, Carla M.
  • Abreu, Carla M. C.

Author identifiers

Ciência ID
E218-D8D7-1EBA
ORCID iD
0000-0002-8070-8388
Scopus Author Id
37025489900

Addresses

  • Institute for Research and Innovation in Health (i3S), Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Genetics and Heredity
  • Natural sciences - Biological Sciences - Developmental Biology
  • Natural sciences - Biological Sciences - Reproductive Biology
  • Natural sciences - Biological Sciences - Microbiology
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2018/09
Concluded
Course in Laboratory Animal Science accredited by FELASA following the recommendations for Category C (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/05/15 - 2018/06/21
Concluded
Postdoctoral Research Fellow in Prof. Maria Jasin Lab (Pós-doutoramento)
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, United States
2013/05 - 2018/05
Concluded
Animal handling courses and training by IACUC and RARC (Outros)
Memorial Sloan Kettering Cancer Center, United States
2008/01/01 - 2013/03/21
Concluded
PhD. student in Prof. Noel Lowndes Lab (Doutoramento)
Biochemistry and Cell Biology Program, National University of Ireland Galway, Ireland
"Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response" (THESIS/DISSERTATION)
2003/09/15 - 2007/12/20
Concluded
Applied Biology Degree (Graduated in the top 5) (Licenciatura)
Universidade do Minho, Portugal
16/20
2007/01/01 - 2007/07/31
Concluded
Undergraduate Final Year Project in Prof. Noel Lowndes Lab (Erasmus Program) (Licenciatura)
National University of Ireland Galway School of Natural Sciences, Ireland
"Structure-Function analysis of the Saccharomyces cerevisiae Mec1, homolog of the human cell cycle master regulator ATR" (THESIS/DISSERTATION)
19/20
2005/07/11 - 2005/07/29
Concluded
Undergraduate Summer Project in Prof. Isabel Mina lab (Outros)
Universidade do Minho Departamento de Biologia, Portugal
Affiliation

Science

Category
Host institution
Employer
2020 - Current Auxiliary Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/09/01 - 2020 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/05/15 - 2018/06/21 Postdoc (Research) Memorial Sloan Kettering Cancer Center, United States
2013/04/21 - 2013/05/04 Visiting Researcher (Research) Universitat Autònoma de Barcelona Facultat de Ciències, Spain

Others

Category
Host institution
Employer
2008/01/01 - 2013/03/21 PhD. student National University of Ireland Galway, Ireland
Projects

Grant

Designation Funders
2023/01 - 2024/06 Investigating the drivers of Fanconi Anemia-associated brain malformations
2022.01964.PTDC
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01 - 2024/06 Dissecting the mechanisms regulating the essential roles of the Dynein-2 motor in cilia
2022.01955.PTDC
Collaborator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018 - 2022/03/25 Investigating the molecular causes of severe Microcephaly: Primary cilium dependent cell cycle control of neural stem cell proliferation during brain development
POCI-01-0145-FEDER-029471
Integration into Research Grant Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2014/05/01 - 2018/05 Homology-directed DNA repair proteins BRCA2 and RAD51 in tumor relevant tissues
info:eu-repo/grantAgreement/NIH/NATIONAL CANCER INSTITUTE/1R01CA185660-01/US
Post-doc
National Institutes of Health
Concluded
2015 - 2017 Threshold effects and non-canonical functions of the tumor suppressor BRCA2 and interacting proteins RAD51 and DSS1
18-A8-104
Post-doc
Developmental Biology Program, Memorial Sloan Kettering Cancer Center, United States
Concluded
2008/01/01 - 2013/03/21 Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response
SFRH/BD/42128/2007
PhD Student Fellow
Universidade do Minho Departamento de Biologia, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. Gonçalves-Santos, Francisco; De-Castro, Ana R.G.; Rodrigues, Diogo R.M.; De-Castro, Maria J.G.; Gassmann, Reto; ABREU, CARLA M.C.#; Dantas, Tiago J.#. Corresponding author: ABREU, CARLA M.C.#. "Hot-wiring dynein-2 establishes roles for IFT-A in retrograde train assembly and motility". Cell Reports 42 11 (2023): 113337. http://dx.doi.org/10.1016/j.celrep.2023.113337.
    Published • 10.1016/j.celrep.2023.113337
  2. De-Castro, Ana R.G.; Rodrigues, Diogo R.M.; De-Castro, Maria J.G.; Vieira, Neide; Vieira, Cármen; Carvalho, Ana X.; Gassmann, Reto; ABREU, CARLA M.C.#; Dantas, Tiago J.#. Corresponding author: ABREU, CARLA M.C.#. "WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing (https://bit.ly/3oY6nq4)". Journal of Cell Biology 221 1 (2022): https://doi.org/10.1083/jcb.202010178.
    Published • 10.1083/jcb.202010178
  3. ABREU, CARLA M.C.#; Dantas, Tiago J.#. Corresponding author: ABREU, CARLA M.C.#. "Coping with centriole loss: pericentriolar material maintenance after centriole degeneration". Communications Biology 4 1 (2021): https://doi.org/10.1038/s42003-021-02243-6.
    Published • 10.1038/s42003-021-02243-6
  4. De-Castro ARG*; Quintas-Gonçalves J*; Ribeiro-Silva T; Rodrigues DRM; De-Castro MJG; ABREU CM#; Dantas TJ#. Corresponding author: ABREU CM#. "The IFT20 homolog in Caenorhabditis elegans is required for ciliogenesis and cilia-mediated behavior". micrPub Biology (2021): https://doi.org/10.17912/micropub.biology.000396.
    Published
  5. ABREU, CM*; Prakash, R*; Romanienko, PJ; Roig, I; Keeney, S; Jasin, M. "Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination". Nature Communications 9 1 (2018): https://doi.org/10.1038/s41467-018-06384-x.
    Published • 10.1038/s41467-018-06384-x
  6. Luo, M; Zhou, J; Leu, NA; ABREU, CM; Wang, J; Anguera, MC; de Rooij, DG; Jasin, M; Wang, PJ. "Polycomb Protein SCML2 Associates with USP7 and Counteracts Histone H2A Ubiquitination in the XY Chromatin during Male Meiosis". PLOS Genetics 11 1 (2015): e1004954. https://doi.org/10.1371/journal.pgen.1004954.
    10.1371/journal.pgen.1004954
  7. ABREU, CM*; Kumar, R*; Hamilton, D; Dawdy, AW; Creavin, K; Eivers, S; Finn, K; et al. "Site-Specific Phosphorylation of the DNA Damage Response Mediator Rad9 by Cyclin-Dependent Kinases Regulates Activation of Checkpoint Kinase 1". PLoS Genetics 9 4 (2013): e1003310. https://doi.org/10.1371/journal.pgen.1003310.
    10.1371/journal.pgen.1003310
  8. Granata, M; Lazzaro, F; Novarina, D; Panigada, D; Puddu, F; ABREU, CM; kumar, R; et al. "Dynamics of Rad9 Chromatin Binding and Checkpoint Function Are Mediated by Its Dimerization and Are Cell Cycle–Regulated by CDK1 Activity". PLoS Genetics 6 8 (2010): e1001047. https://doi.org/10.1371/journal.pgen.1001047.
    10.1371/journal.pgen.1001047
Newsletter article
  1. -. "Universidade do Porto descobre forma de corrigir malformações embrionárias (através de manipulação genética)", Sic Notícias, 2023, https://t.ly/TRg6y.
  2. -. "Manipulação genética permite corrigir defeitos de malformações embrionárias, diz estudo português", TVI Notícias, 2023, https://t.ly/4TnCK.
  3. -. "Equipa do i3S descobre como corrigir malformações associadas a doenças genéticas", Notícias Universidade do Porto, 2023, https://t.ly/nacue.
  4. -. "Manipulação genética permite corrigir defeitos de malformações embrionárias", Jornal Médico, 2023, https://t.ly/5abUl.
Newspaper article
  1. -. "Manipulação genética permite corrigir defeitos de malformações embrionárias", Público, 2023, https://shorturl.at/mLPTZ.
  2. -. "Manipulação genética permite corrigir defeitos de malformações embrionárias, mostra estudo", Observador, 2023, https://shorturl.at/ezELM.
  3. -. "Universidade do Porto: manipulação genética permite corrigir malformações embrionárias", Jornal de Notícias (JN), 2023, https://shorturl.at/delQ4.
  4. -. "Manipulação genética permite corrigir defeitos de malformações embrionárias, diz estudo português", CNN Portugal, 2023, https://shorturl.at/ahjG2.
  5. -. "Manipulação genética permite corrigir defeitos de malformações embrionárias", Diário de Notícias, 2023, https://t.ly/_xjof.
  6. "Descoberta uma das causas de malformações embrionárias de algumasdoenças genéticas", Diario de Noticias (DN), 2021, https://www.dn.pt/ciencia/descoberta-uma-das-causas-de-malformacoes-embrionarias-de-algumas-doencas-geneticas-14395304.html.
  7. "Investigadores portugueses descobrem uma das causas de malformaçõesembrionárias de algumas doenças genéticas", CNN Portugal, 2021, https://cnnportugal.iol.pt/i3s/porto/investigadores-portugueses-descobrem-uma-das-causas-de-malformacoes-embrionarias-de-algumas-doencas-geneticas/20271231/61b326ae0cf2c7ea0f0cd219.
  8. "Descoberta uma das causas de malformações embrionárias de algumas doenças genéticas", Observador, 2021, https://observador.pt/2021/12/10/descoberta-uma-das-causas-de-malformacoes-embrionarias-de-algumas-doencas-geneticas/.
  9. "Descoberta uma das causas de malformações embrionárias de algumas doenças genéticas", Jornal Online, 2021, https://jornalonline.pt/descoberta-uma-das-causas-de-malformacoes-embrionarias-de-algumas-doencas-geneticas/.
Preprint
  1. Gonçalves-Santos F.; De-Castro, Ana R.G.; Rodrigues, Diogo R.M.; De-Castro, Maria J.G.; Gassmann, Reto; ABREU, CARLA M.C.#; Dantas, Tiago J.#. Corresponding author: Dantas, Tiago J.#. "Hot-wiring dynein-2 uncovers roles for IFT-A in retrograde train assembly and motility". 2023.
  2. De-Castro, Ana R.G.*; Rodrigues, Diogo R. M.*; De-Castro, Maria J.G.; Vieira, Neide; Vieira, Cármen; Carvalho, Ana C.; Gassmann, Reto; ABREU, CARLA M.C.#; Dantas, Tiago J.#. Corresponding author: ABREU, CARLA M.C.#. "WDR60-mediated dynein-2 loading into cilia powers retrograde IFT and transition zone crossing". 2021. https://doi.org/10.1101/2021.09.19.459328.
  3. ABREU, CARLA M.*; Prakash, Rohit*; Romanienko, Peter J.; Roig, Ignasi; Keeney, Scott; Jasin, Maria. "bioRxiv: Shu complex SWS1-SWSAP1 is required for mouse meiotic recombination in concert with the BRCA2 C terminus". 2017. https://doi.org/10.1101/238196.
Thesis / Dissertation
  1. Abreu, Carla M.. "Analysis of Saccharomyces cerevisiae Mec1 and Rad9 functions in the DNA Damage Response". PhD, National University of Ireland Galway School of Health Sciences, 2013. https://aran.library.nuigalway.ie/bitstream/handle/10379/3603/PhDThesis_AbreuCMC.pdf?sequence=1&isAllowed=y.
Working paper
  1. De-Castro MJG; Fonseca L; Sousa MFS; Dantas TJ#; ABREU CMC#. Corresponding author: ABREU CMC#. 2024. "BRCA2-mediated repair ensures the faithful segregation of centrosomes in Caenorhabditis elegans spermatocytes.".

Other

Other output
  1. Cover selected for issue at Journal of Cell Biology. 2022. Maria J. De-Castro; ABREU, CARLA M.C.#; Dantas, T.J.#. https://rupress.org/jcb/issue/221/1..
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2022/10/05 Why are some organs more susceptible to cancer than others? 5ª edition of the Pint of Science Festival (Portugal); https://www.pintofscience.pt/oradores
Pint of Science (Guimarães, Portugal)
2018/11/01 DNA repair mechanisms required for meiotic progression involving SWS1-SWSAP1 and BRCA2 Invited seminar and 2-day visit
Wellcome Centre for Human Genetics , University of Oxford (Oxford, United Kingdom)
2018/09/26 DNA Repair Mechanisms Required For Meiotic Progression Invited Seminar
Institute for Research and Innovation in Health (i3S) (Porto, Portugal)
2017/10/02 The Mouse Shu Complex SWS1-SWSAP1 is Essential for Meiotic Recombination The New York Academy of Science - Genome Integrity Discussion Group
The New York Academy of Sciences (New York, United States)
2017/08/31 The mouse Shu complex SWS1-SWSAP1 is essential for meiotic recombination EMBO Conference on Meiosis 2017
European Molecular Biology Organization (EMBO) (Hvar, Croatia)
2016/06/26 Genetic Interaction Between BRCA2 C-Terminus and RAD54 During Germ Cell Development 2016 Gordon Research Seminar on Meiosis - Mechanisms of Sexual Reproduction Through Meiosis
Gordon Research Conferences (New Hampshire, United States)
2015/05 Genetic Interaction Between BRCA2 C-Terminus and RAD54 During Germ Cell Development Developmental Biology Colloquium
Memorial Sloan Kettering Cancer Center (New York, United States)
2009/10/17 A novel regulation model for Saccharomyces cerevisiae Mec1, homologue of ATR kinase Irish Radiation Research Society Scientific Meeting 2009
Irish Radiation Research Society (Galway, Ireland)
2008/06/24 A novel regulation model for Saccharomyces cerevisiae Mec1, homologue of ATR Kinase 2nd EU-IP DNA Repair: Workshop for Young Scientists & Career Event
EU-IP (Porto, Portugal)

Supervision

Thesis Title
Role
Degree Subject (Type)
Institution / Organization
2023/12 - Current Dissecting the mechanisms mediating Dynein-2 incorporation into cilia and their implications for ciliopathies (PhD scholarship awarded by FCT: 2023.01378.BD)
Supervisor of Maria João De-Castro
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/09 - Current Studying ciliary dynamics upon loss of ciliopathy-associated genes
Supervisor of Maria João Monteiro
Engenharia Biomédica (Master)
Universidade do Minho, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/01 - Current Dissecting the mechanisms of ciliary gating: interplay between Dynein-2 and the transition zone (PhD scholarship awarded by i3S/FCT: UI/BD/1528652022)
Co-supervisor of Ana R.G. De-Castro
PhD in Molecular and Cell Biology (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2021/10 - Current Dissecting the NDE1/LIS1-dependent regulation of Dynein-mediated transport in the brain (PhD scholarship awarded by FCT: 2021.04761.BD)
Co-supervisor of Tiago Xavier Ribeiro
PhD Biomedical Sciences (ICBAS, UP) (PhD)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2019/11 - Current Uncovering the mechanisms regulating the essential roles of Dynein-2 in cilia function (PhD scholarship awarded by FCT: SFRH/BD/143985/2019)
Co-supervisor of Diogo Rodrigues (PhD. student)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/10 - 2023/12 Investigating the drivers of Fanconi Anemia-associated brain malformations
Supervisor of Maria João De-Castro
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/02 - 2023/10 Investigating a role for the IFT- A complex in the recruitment of molecular motors to neuronal cilia
Co-supervisor of Francisca Bryant-Jorge
Molecular Bioengineering (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/02 - 2023/10 Recruitment and loading of Dynein-2 into cilia to ensure signaling functions
Co-supervisor of Luisa de Sousa Fonseca
Molecular Medicine and Oncology (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2023/02 - 2023/08 Dissecting the mechanisms regulating the essential roles of the Dynein-2 motor in cilia
Co-supervisor of Francisco Gonçalves Santos (currently a PhD student at Oxford University, UK)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/09 - 2023/07 Interplay between BRCA2 and the Spindle Assembly Checkpoint in Caenorhabditis elegans
Supervisor of Maria Francisca Sarmento Sousa
Biology (Degree)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/09 - 2022/10 Investigating the essential roles of BRCA2 during embryonic development in C. elegans (Master degree project; final score 20/20)
Supervisor of Maria João De-Castro (Master student)
Molecular Medicine and Oncology (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2021/04 - 2022/10 Investigating Dynein-2 regulation during intraflagellar transport in Cilia (Master degree project; final score 20/20)
Co-supervisor of Francisco Gonçalves Santos (prospect PhD student at Oxford University)
Molecular Medicine and Oncology (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2022/09/01 - 2022/09/30 BIIverao-i3S-18072207-2022: Investigating the contributions of BRCA2 for cell proliferation in Caenorhabditis elegans
Supervisor of Maria João De-Castro
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/10 - 2021/12 The roles of IFT-20 in C. elegans cilia
Co-supervisor of Joana Quintas Gonçalves
Visiting researcher (Other)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2019/06 - 2020/12 Ciliary recruitment of the dynein-2 motor and its role in C. elegans sensory functions (Master degree project; final score 20/20)
Co-supervisor of Ana R.G. De-Castro
MSc Program in Biomedical Sciences - Diseases Mechanisms (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2020/05 - 2020/10 Primary cilium-dependent cell cycle control of neural stem cell proliferation during brain development
Co-supervisor of José Costa Gama (Postdoc)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2020/04 - 2020/10 Investigating the cell dynamics of the essential tumour supressor BRCA2 during C. elegans development (bachelor's degree final project; final score 19/20)
Supervisor of Ana R.G. De-Castro (final year's Bachelor degree student)
Ciências Biomédicas Laboratoriais (Degree)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2020/01 - 2020/09 Mechanisms governing Dynein-2 stability
Co-supervisor of Marcos Machado - volunteer student (currently a Master student at KTH, Stockholm, Sweden)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2018/03 - 2019/11 Dissecting the molecular causes of NDE1-associated microcephaly (Master degree project; final score 19/20)
Co-supervisor of Carmen Leal Vieira (currently a Researcher at ICVS, Braga, Portugal)
Neurobiology (Master)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2010/01 - 2010/05 Generation and characterisation of novel alleles of Mec1, the budding yeast homologue of human ATR
Co-supervisor of Clara Sanz Nogués (undergraduate Erasmus student)
National University of Ireland Galway School of Health Sciences, Ireland

Universitat de València, Spain
2008/11 - 2008/12 The analysis of the genetic dependency of Mec1 kinase phosphorylation
Co-supervisor of Paula Lee (undergraduate student)
National University of Ireland Galway School of Health Sciences, Ireland

Event organisation

Event name
Type of event (Role)
Institution / Organization
2023/11 - 2023/11 Organized and Spearheaded outreaching Lectures and Workshops integrated in the Projeto SEI (Sociedade, Escolas and Investigação) to high school students of Agrupamento de Escolas Alexandre Herculano as part of National educational programs (2023/11/02 - 2023/11/23)
Workshop (Co-organisor)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Agrupamento de Escolas Alexandre Herculano, Portugal
2023/03/13 - 2023/03/13 Coordinator of outreach activities and workshops integrated into a scientific exhibition of the C. elegans nervous system at i3S for secondary-school students (7th to 9th grade) as part of the International Brain Week 2023 and National Educational Programs. (2023/03/13 - 2023/03/17)
Workshop (Member of the Organising Committee)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2017/06/09 - 2018/06/10 2018 Gordon Research Seminar - Mechanisms and Regulation of Gametogenesis Through Meiosis (https://www.grc.org/meiosis-grs-conference/2018/) (2018/06/09 - 2018/06/15)
Conference (Co-organisor)
Colby-Sawyer College, United States

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2023/11 Unraveling how TLX3 antagonizes the action of LBX1 during the development of spinal glutamatergic neurons.
(Thesis) Main arguer
Diana Barcelos Carvalho (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/10 The role of CD147 in tumor immunosuppression
(Thesis) Main arguer
Francisco José Ferreira Vilaça (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho Escola de Ciências da Saúde, Portugal
2023/10 Effect of 3-Bromopyruvate in the response to chemotherapy in the in vivo chicken embryo model of Acute Myeloid Leukemia
(Thesis) Main arguer
Filipa Rodrigues Pimentel (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Universidade do Minho Escola de Ciências da Saúde, Portugal
2020/01/08 Linking autophagy to feeding status: the function of egli-1 in the Caenorhabditis elegans nervous system
(Thesis) Main arguer
Jorge Diogo Cruz Ramos da Silva (Master)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Conference scientific committee

Conference name Conference host
2016/09/24 - 2016/09/25 PAPS XVI forum “From 66 to 0 degrees of Separation: the Power of Networks” Memorial Sloan Kettering Cancer Center, New York, USA
2006/11 - 2006/11 Member of the scientific organising committee of the VIII Conferences of Applied Biology University of Minho, Braga, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2008/09 - 2012/06 Instructor in pratical classes for undergraduates of Biochemistry and Cell Biology degree at National University of Ireland Galway Biochemistry and Cell Biology (Bachelor) National University of Ireland Galway College of Science, Ireland

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Invited Reviewer for: Environmental and Molecular Mutagenesis Wiley
2020 - Current Invited Reviewer for: Communications Biology Nature Publishing Group

Mentoring / Tutoring

Topic Student name
2015 - 2017 Immunofluorescent imaging analyses Undergraduate Students of Summer Programs at Memorial Sloan Kettering Cancer Center, NY, USA
2012/01 - 2012/09 Instructor of basic microbiology techniques in schools as part of the first volunteer group of the Cell EXPLORERS science education and outreach program (https://www.cellexplorers.com/). Primary School students, in Ireland
2011/10 - 2012/05 Genetic analysis of ATR, a central regulator of genome stability Marta Llorens Agost (PhD. student), Ireland
2011 - 2011 Instructor of basic scientific experiments to the general public in a science fair in Ireland with the purpose of a science education and outreach activity. General Public, Galway Science & Technology Exhibition, Ireland

Other jury / evaluation

Activity description Institution / Organization
2020/08 - 2020/10 Jury of poster and oral presentations at the 3rd PhDay Meeting "Back to the Future", at the Institute of Investigation and Innovation in Health (i3S) in Porto Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Scientific expedition

Activity description Institution / Organization
2005/08/01 - 2005/08/15 Summer Volunteer Project to study of stork migration Colectivo Ornitológico Cigüeña Negra, Spain
Distinctions

Award

2020 6-year FCT Scientific Employment Stimulus Grant (CEECIND/01985/2018)
Fundação para a Ciência e a Tecnologia, Portugal
2017 Scholarship award to attend the FASEB Conference on Genetic Recombination and Genome Rearrangements
Federation of American Societies for Experimental Biology, United States
2015 Scholarship award to attend the Ramon Areces Foundation International Symposium on "The biology of meiosis: implications for fertility and genetic disorders"
Fundación Ramon Areces, Spain
2008 4-Year Doctoral fellowship award (SFRH/BD/42128/2007)
Fundação para a Ciência e a Tecnologia, Portugal
2007 Erasmus scholarship award
European Commission, Belgium

Other distinction

2022 Supervised work awarded as best oral presentation in 2 scientific meetings (IJUP and EUGLOH)
2019 (co-)Supervisor of 4 PhD students, all awarded with personal PhD scholarships