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The specialization of Maria Cristina das Neves Oliveira is in the field of synthetic organic chemistry and radiochemistry. In the last years the main focus of her scientific activity lies on the synthesis and characterization of halogen-based compounds with potential application in molecular imaging and systemic radiotherapy of oncological diseases. In this field emphasis has been placed on the study of novel routes to the synthesis and characterization of small molecules (eg. steroids, tyrosine kinase inhibitors) with potential application in the clinical care of cancer patients and the establishment of chemical structure-biological activity relationships based on the determination of their biological behaviour. Her main research interests include radiolabelling (123/125I,18F) of biomolecules with high affinity and selectivity for estrogen receptors, found mainly in breast and uterine tissues, as well as on EGFR/VEGFR tyrosine kinase inhibitors that can be potential SPECT/PET imaging agents for monitoring EGFR overexpressing tissues and angiogenesis, respectively. Scientific activities were also extended to the radiosynthesis and characterization of thyroid hormones, peptides, proteins, nanoparticles and other small molecules with potential clinical application. The present research interests are focused on the synthesis and characterization of novel biomolecules for therapy of cancer, based on Auger-emitting radionuclides.
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Identification

Personal identification

Full name
Maria-Cristina das Neves Oliveira

Citation names

  • Oliveira, Maria-Cristina
  • M. C. Oliveira
  • C. Oliveira
  • C. das Neves Oliveira
  • M. C. Melo e Silva

Author identifiers

Ciência ID
E21A-316D-935F
ORCID iD
0000-0002-5708-3885

Email addresses

  • cristinaoliveira@ctn.tecnico.ulisboa.pt (Professional)

Telephones

Telephone
  • (351) 219946201 (Professional)
  • (351) 219946195 (Professional)

Addresses

  • Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa. Centro de Ciências e Tecnologias Nucleares (C2TN), Instituto Superior Técnico, Universidade de Lisboa, Campus Tecnológico e Nuclear, Estrada Nacional 10, 2695-066, Bobadela LRS, Loures, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Exact Sciences - Chemical Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Upper intermediate (B2) Advanced (C1) Advanced (C1) Upper intermediate (B2) Advanced (C1)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2000
Concluded
 Provas publicas para acesso á categoria de Investigador Auxiliar (Outros)
Instituto Tecnológico e Nuclear, Portugal
1990
Concluded
 Provas publicas para acesso à categoria de Assistente de Investigação (Outros)
Laboratório Nacional de Engenharia e Tecnologia Industrial, Portugal
1982
Concluded
 Engenharia Química (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Affiliation

Science

Category
Host institution 		Employer
2012 - Current Auxiliary Researcher (Research) Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2000 - 2012 Auxiliary Researcher (Research) Instituto Tecnológico e Nuclear, Portugal
1990 - 2000 Research Assistant (Research) Instituto Tecnológico e Nuclear, Portugal
1985 - 1990 Research Trainee (Research) Laboratório Nacional de Engenharia e Tecnologia Industrial, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
1983 - 1985 Trainee Assistant (University Teacher) Universidade da Beira Interior, Portugal
Outputs

Publications

Conference paper
  1. S. Cunha, C. Fernandes, F. Marques, M.C. Oliveira, I. Santos, L. Gano. "67Ga estradiol based complexes for breast cancer ER+ imaging: synthesis and preclinical evaluation". Paper presented in 10th Inorganic Chemistry-Sociedade Portuguesa de Química, Costa da Caparica, 2014.
  2. M. Morais, P. D. Raposinho, M. C. Oliveira, J. D. G. Correia, I. Santos. "(99m)Tc(1)-Cyclic alpha-MSH Analogs for MC1R Targeting". 2011.
  3. M. Morais, P. D. Raposinho, M. C. Oliveira, J. D. G. Correia, I. Santos.. "Homobivalent alpha-MSH Derivatives for Melanoma Imaging: 99mTc(CO)3-Labeling and Biological Evaluation". Paper presented in 31st European Peptide Symposium European Peptide Society, 2010.
  4. C. Neto, M.C. Oliveira, L. Gano, F. Marques, I. Santos, T. Thiemann. "Novel estradiol based metal complexes of Tc-99m for breast cancer imaging". Paper presented in Int Symp. on Technetium and Other Radiometals in Chemistry and Medicine Padova, Padova, 2010.
  5. T. Yasuda, S. Tsurukawa, T. Thiemann, M. C. Das Neves Oliveira, C. Neto, L.Gano, F. Marques, G. R. Morais, A. C. Santos,. "C7- and C17- Substituted Estrane Derivatives As Potential Cancer Diagnostic Agents". Paper presented in 10th Cross Straits Symposium on Materials, Energy and Environmental Engineering (CSS-10), Kyushu University, Fukuoka, 2008.
  6. K. Shiine, C. Burmester, M. Watanabe, T. Thiemann, M. C. Oliveira, C. Neto, L. Gano, A. C. Santos, F. Botelho, C. Olivei. "Ring-annelated Estrane". Paper presented in 9th Cross Straits Symposium on Materials, Energy and Environmental Engineering (CSS-9, POSTECH), Pohang University of Technology, Pohang, South Korea, Pohang, 2007.
  7. T. Yasuda, T. Thiemann, M. C. Oliveira, C. Neto, L. Gano, G. Morais, C. Santos, F. Botelho, C. Oliveira. "Substituted-1,3,5(10)-tetraen-3,17beta-diols as potential radioligands for the estrogen receptor alpha synthesis and biochemical behaviour". Paper presented in 9th Cross Straits Symposium on Materials, Energy and Environmental Engineering (CSS-9, POSTECH), Pohang University of Technology, Poha, Pohang, 2007.
  8. T. Thiemann, M. Watanabe, J. Wang, T. Matsumoto, C. Yamamoto, S. Mataka, L. Gano, F. Marujo Marques, M. C. Melo e Silva. "Novel Estrone Compounds for Radiolabeling". Paper presented in 4th Cross Straits Symposium (CSS-4), Fukuoka, 2002.
  9. E. Inohae, T. Thiemann, S. Mataka, M. C. Melo e Silva, L. Gano, F. Marujo Marques, L. Patrício, M. L. Sá e Melo. "New Radioligands for the Estrogen Receptor ERalpha as Potential Diagnostic Tools for Human Breast Cancer". Paper presented in 1st Cross Straits Symposium, (CSS-1), Fukuoka, 1999.
  10. P. Raposinho, M. C. Oliveira, A. Rodrigues, I. Santos, L. Patrício. "Preparation and Characterization of Reagents for Direct Radioimmunoassay of Cortisol". Paper presented in Radioimmunoassay and Related Procedures: perspectives in Developing Countries IAEA-SM-324/57, WHO International Symposium, 1991.
Conference poster
  1. F. Vultos, M. Belo, M. Scheepstra, C. Fernandes, M. C. Oliveira, F. Mendes, L. Brunsveld, J. D.G. Correia, I.Santos, L.. "Radiolabeled peptides targeting the estrogen receptor for breast cancer theranostics: 111In- versus 125I-labelling". 2017.
  2. E. Pereira, A. Paulo, M. C. Oliveira, F. Mendes, P. Raposinho, A. Belchior, I. Correia, J. Lavrado.. "Radioiodinated compounds for Auger therapy". 2016.
  3. J. Correia, L. Gano, I. Santos, I. D. Serrano, S. S. Santos, M. Ribeiro, J. Perazzo, I. Tavares, M. Heras, E. Bardaji, M. "Biological Evaluation of Radioiodinated Amidated Kyotorphin". 2016.
  4. E. Pereira, L. do Quental, M.C. Oliveira, P. Raposinho, A. Belchior, S. Di Maria, I. Correia, J. Lavrado, F. Mendes, P.. "Radiolabeled Acridine Orange (AO) Derivatives as DNA-Targeted Probes for Auger Therapy, Radiotherapy and Oncology". 2016.
  5. V. Cachatra, S. Schwarz, M. C. Oliveira, L. Gano, A. Paulo, A..P. Rauter. "Butyrylcholinesterases as a target for degenerative disease therapies". 2015.
  6. F. Vultos, M. Belo, C. Fernandes, J. D. G. Correia, M. C. Oliveira, I. Santos, L. Gano. "Influence of the radionuclide on the stability and biological profile of a ER targeting peptide". Paper presented in Workshop LOWDOSE-PT- 2015, Biological effects and risks of low dose and protected exposures to ionizing radiation, 2015.
  7. V. Cachatra, S. Schwarz, M. C. Oliveira, L. Gano, A. Paulo, A. P. Rauter. ". Targeting Butyrycholinesterase for New Treatments in Alzheimer’s Disesase and Cancer". 2015.
  8. M. Morais, P. D. Raposinho, M. C. Oliveira, M. A. Jiménez, D. Pantoja-Uceda, J.D. G. Correia, I. Santos,. "MC1R-Targeted Metallopeptides: NMR Structural Analysis Chemistry of Metals in Biological Systems". Paper presented in Summer School, COST Action CM 1105, Lisbon, Portugal,, 2013.
  9. "New benzimidazole derivatives for the targeting of beta-amyloid aggregates". Paper presented in EMIM 2013, 2013.
  10. S. Cunha, F. Vultos, C. Fernandes, M.C. Oliveira, M. F. Botelho, I. Santos, L. Gano. "Novel 111In-estradiol based complexes: preclinical evaluation for oestrogen positive tumour targeting". 2012.
  11. S. M. Cunha, F. J. Vultos, C. Fernandes, M. C. Oliveira, L. Gano, I. Santos. "Synthesis and characterization of novel DOTA-Estradiol derivatives targeting the Estrogen Receptor". Paper presented in XXV International Conference on Organometallic Chemistry, Lisbon, 2012.
  12. M. Morais, P. D. Raposinho, M. C. Oliveira, M. A. Jiménez, D. Pantoja-Uceda, J. D. G. Correia, I. Santos. "Design, characterization and evaluation of cyclized a-MSH Derivatives for MC1R Targeting". 2012.
  13. S. Cunha, C. Fernandes, M. C. Oliveira, L. Gano, I. Santos. "Synthesis and preclinical evaluation of 67Ga-/111In-estradiol based complexes for tumour imaging". 2012.
  14. M. Morais, B. L. Oliveira, J. D. G. Correia, M. C. Oliveira, I. Santos, P. D. Raposinho. "Modulation of the Pharmacokinetic Properties of 99mTc(CO)3-ßAla-MTII". Paper presented in XIII Iberian Peptide Meeting, Alicante, Spain, 2012.
  15. J. D. G. Correia, M. MoraiS, P. D. Raposinho, M. C. Oliveira, I. Santos, M. A. Jiménez, D. Pantoja-Uceda. "MC1R-targeting properties of 99mTc(I)-labeled cyclic a-MSH analogs with thioether or amine bridge". Paper presented in XIII Iberian Peptide Meeting, Alicante, Spain, 2012.
  16. Carina Neto, Célia Fernandes, Cristina Oliveira, Lurdes Gano, Filipa Mendes, Torsten Kniess, Isabel Santos. "Radiosynthesis and biological evaluation of novel receptor tyrosine kinase inhibitors for in vivo targeting of EGFR". Paper presented in 19th International Symposium on Radiopharmaceutical Sciences Amsterdam, 2011.
  17. Susana Cunha, Célia Fernandes, M. Cristina Oliveira, Lurdes Gano, Isabel Santos. "6th European Molecular Imaging Meeting –EMIM 2011, Leiden, The Netherlands". 2011.
  18. Susana Cunha, Célia Fernandes, M. Cristina Oliveira, Lurdes Gano, Isabel Santos. "Síntese e caracterização de complexos derivados do estradiol para diagnóstico e/ou terapia do cancro da mama". Paper presented in 1º Encontro dos alunos de doutoramento do DQB - FCUL, 2011.
  19. M. Morais, Paula D. Raposinho, M. C. Oliveira, João D. G. Correia, Isabel Santos. "A New Thioether Bridge-Cyclized a–MSH Derivative: Synthesis, Labelling with 99mTc(I) and Biological Evaluation". 2010.
  20. C. Neto, M.C. Oliveira, C. Fernandes, L. Gano, F. Mendes, T. Kniess, I. Santos. "Radiosynthesis and biological evaluation of novel receptor tyrosine kinase inhibitors for in vivo targeting of EGFR". 2010.
  21. T. Kniess, C. Oliveira, M. Kuchar, L. Gano, I. Santos, J. Steinbach. "Synthesis and first radiopharmaceutical investigation of 5-[125I]Iodo-SU11248, a potential radiotracer for imaging VEGFR, .". Paper presented in EANM'10, Vienna, Austria, 2010.
  22. C. Neto, M.C. Oliveira, L. Gano, F. Marques, I. Santos, T. Thiemann,. "Novel estradiol based metal complexes of Tc-99m for breast cancer imaging". 2010.
  23. C. Neto, M.C. Oliveira, L. Gano, F. Marques, I. Santos, G.R. Morais, T. Yasuda, T. Thiemann, F. Botelho, C.F. Oliveira; C. Neto, M. C. Oliveira, L. Gano, F. Marques, I. Santos, G. R. Morais, T. Yasuda, T. Thiemann, F. Botelho, C. F. Oliveir. "Novel Radioiodinated estradiols as potential imaging agents for estrogen positive breast tumours". Paper presented in CIÊNCIA 2010 – Encontro com a Ciência e a Tecnologia em Portugal, Centro de Congressos de Lisboa, 2010.
  24. C. Neto, M. C. Oliveira, L. Gano, F. Marques, I. Santos, T. Yasuda, T. Thiemann, A. C. Santos, F. Botelho, C. F. Oliveir. ", Avaliação do Potencial Clínico de Novos Radioligandos para o Receptor Estrogénico em Diagnóstico e/ou Terapia". 2009.
  25. C. Neto, M. C. Oliveira, L. Gano, F. Marques, I. Santos, T. Thiemann. "Estradiol Based Metal Complexes for Breast Cancer Diagnosis". 2009.
  26. C. Neto, M. C. Oliveira, L. Gano, F. Marques, I. Santos, G. R. Morais, T. Yasuda, T. Thiemann, F. Botelho, C. F. Oliveir. "Substituted estra-1,3,5(10),6-tetraen-3,17ß-diols as potential ligands for the estrogen receptor - synthesis and biochemical studies". 2008.
  27. C. Neto, M. C das Neves Oliveira, L Gano, F. Marujo, I. Santos, G. Morais, C. Santos, F. Botelho, C. F. Oliveira, T. Yas. ". Novel Estra-1,3,5(10),6(7)-Tetraen-3,17beta-Diols As Potential Radioligands For The Estrogen Receptor ER". Paper presented in 10th Eurasia Conference on Chemical Sciences, EuAsC2S Manila, Philippines, 2008.
  28. C. Neto, C. Fernandes, C. Oliveira, L. Gano, A. Bourkoula, I. Pirmettis, I. Santos.. "Radiolabelled 6-substituted-4-haloquinazolines as potential SPECT probes for EGFR positive tumors". 2007.
  29. C. Neto, M. C. Oliveira, L. Gano, F. Marques, I. Santos, G. Morais, T. Yasuda, T. Thiemann, C. Santos, F. Botelho, C. Ol. "Substituted estra-1,3,5(10),6-tetraen-3,17ß-diols as potential ligands for the estrogen receptor: synthesis and biochemical studies". Paper presented in Western Japan Chemistry Conference, Okayama, Japão, 2007.
  30. N. Yoshioka, T. Matsumoto, M. Watanabe, G. Morais, M. C. Oliveira, M. Videira, A. Almeida, L. Gano, C. Neto, F. Marques,. "Ring Annelated Estranes as Potential Cancer Diagnostic Agents". 2006.
  31. C. Neto, M.C. Oliveira, M. Videira, L. Gano, M. Watanabe, T. Thiemann, A.C. Santos, F. Botelho, C. Oliveira. "Radioiodinated ligands for the estrogen receptor. Effect of E-ring methylation on the biological behaviour of novel E-ring expanded estranes". 2006.
  32. G. R. Morais, T. Matsumoto, M. Watanabe, N. Yoshioka, C. das Neves Oliveira, L. Gano, F. Marques, A. C. Santos, F. Botel. "Synthetic Estrane derived Steroids as potential Radiodiagnostics and Drug Delivery Systems for Minimal Breast Cancer". 2006.
  33. C. Fernandes, M. C. Oliveira, L. Gano, A. Almeida, I. Pirmettis, I. C. Santos, I. Santos. "Promising SPECT Biomarkers for Molecular Imaging of EGFR Positive Tumours.". Paper presented in 7th European Biological Inorganic Chemistry Conference, EUROBIC8 Aveiro, Portugal,, 2006.
  34. M. C. Oliveira, M. Videira, A. Almeida, L. Gano, M. Watanabe, T. Thiemann, A.C. Santos, F. Botelho, C. Oliveira. "Auger Emitters in Radiotherapy: Novel Estrogen Receptor Ligands". 2006.
  35. M.C. Oliveira, C. Fernandes, I. Santos. ". Radioiodination of New EGFR Inhibitors as Potential SPECT Agents for Molecular Imaging of Breast Cancer". 2005.
  36. M.C. Melo e Silva, M.M. Marques, G.G. Costa, J. Wang, T. Thiemann.. "Synthesis, Radiolabelling and HPLC Purification of Steroidal and Non-Steroidal Biomolecules as Radioiomaging Agents for Human Breast Cancer". Paper presented in 3º Encontro Nacional de Cromatografia, Lisboa, 2003.
  37. K.G. Dongol, M. Watanabe, M.C Melo e Silva, S. Mataka, T. Thiemann. "Pd-catalysed C-C bond forming reactions with arene-chromium complexes". 2003.
  38. M.C. Melo e Silva, G.R Morais, F. Roleira, E.T da Silva, J. Wang, M. Watanabe, S. Mataka, T. Thiemann; M.C. Melo e Silva, G.R Morais, F. Roleira, E.T da Silva, J. Wang, M. Watanabe, S. Mataka, T. Thiemann.. "Synthesis and Radiosynthesis of 17a-[p-(Iodophenylethynyl)] estra-3,17ß-diols". Paper presented in 16th Joint Seminar between Kyushu Branch of the Chemical Society of Japan and Pusan Branch of the Korean Chemical Society, Oita, Japão, 2003.
  39. M.C. Melo e Silva, K.G. Dongol, T. Thiemann. "Pi-Facial Selectivity in the Formation of Tricarbonylchromium(0) Complexes of Estra-1,3,5(10),6-tetraenes". 2003.
  40. T. Thiemann, M. Watanabe, J. Wang, T. Matsumoto, C. Yamamoto, S. Mataka, L. Gano, F. Mar.ujo Marques, M. C. Melo e Silva. "Novel Estrone Compounds for Radiolabeling". Paper presented in 4th Cross Straits Symposium (CSS-4), Fukuoka, 2002.
  41. T. Thiemann, M. Watanabe, J. Matsumoto, C. Melo e Silva, F. Marujo-Marquez, L. Gano.. "Composites Peptides-Steroids/Alkaloids derived from Estrones". 2002.
  42. M. Imai, Y. Shima, K. Umeno, E. Inohae, C. Melo e Silva, S. Mataka, T. Thiemann. "Approaches to Hybrids of Estra-1,3,5(10),6-tetraenes with Biologically Active Molecules". 2002.
  43. M. C. Melo e Silva, G. G. Costa, M. M. Marques. "Studies towards the Synthesis of beta-halo Tamoxifen Derivative". 2001.
  44. P.C. Pereira, M. C. Melo e Silva, G. G. Costa, M. M. Marques. "A New Synthetic Approach to ß-Halo-alpha-Hydroxytamoxifen". Paper presented in 4º Encontro Nacional de Química Orgânica, Universidade de Coimbra, Portugal, 2001.
  45. K. Umeno, T. Thiemann, E. Inohae, S. Mataka, M. C. Melo e Silva, L. Patrício, L. Gano, A. C. Santos, F. Marujo Marques. "C-7 substituted estra-1,3,5(10),6-tetraenes as New Radioligands for the Estrogen Receptor ERalpha". 2000.
  46. E. Inohae, T. Thiemann, K. Umeno, S. Mataka, M. C. Melo e Silva, L. Patrício, F. Marujo Marques. "Synthesis and Evaluation of C-7 substituted estra-1,3,5(10),6 tetraenes as Diagnostica for Estrogen Positive Human Breast Cancer". 2000.
  47. M. C. Melo e Silva, L. Gano, M. L. Sá e Melo, E. Inohae, S. Mataka, L. Patrício, T. Thiemann. "Estudo das Propriedades de Dois Derivados Radioiodados do Estradiol". 1998.
  48. M. C. Melo e Silva, M. L. Sá e Melo, E. Inohae, S. Mataka, T. Thiemann. "Synthesis and Biodistribution of Potential Radiopharmaceuticals for Estrogen positive Breast Cancers". Paper presented in 25th Kuju Symposium, Kuju, Japão, 1998.
  49. M. C. Melo e Silva, T. Thiemann, L. Patrício, M. L. Sá e Melo. "17alpha- 125I-Iodovinyl derivatives of 3-Methoxy-6-Dehydroestradiol: Potential Radioligands for the Estrogen Receptor,". Paper presented in 2º Encontro Nacional de Química Orgânica, Oeiras, 1997.
Journal article
  1. Figueiredo, Joana; Peitinho, David; Campello, Maria Paula Cabral; Oliveira, Maria Cristina; Paulo, António; Mergny, Jean-Louis; Cruz, Carla. "Screening of Scaffolds for the Design of G-Quadruplex Ligands". Applied Sciences 12 4 (2022): 2170. http://dx.doi.org/10.3390/app12042170.
    10.3390/app12042170
  2. Caccuri, Francesca; Neves, Vera; Gano, Lurdes; Correia, João D. G.; Oliveira, Maria Cristina; Mazzuca, Pietro; Caruso, Arnaldo; Castanho, Miguel. "The HIV-1 Matrix Protein p17 Does Cross the Blood-Brain Barrier". Journal of Virology 96 1 (2022): http://dx.doi.org/10.1128/jvi.01200-21.
    10.1128/jvi.01200-21
  3. Oliveira, Maria Cristina; Correia, João D. G.. "Clinical application of radioiodinated antibodies: where are we?". Clinical and Translational Imaging (2022): http://dx.doi.org/10.1007/s40336-021-00477-2.
    10.1007/s40336-021-00477-2
  4. Silva, Francisco; D’Onofrio, Alice; Mendes, Carolina; Pinto, Catarina; Marques, Ana; Campello, Maria Paula Cabral; Oliveira, Maria Cristina; et al. "Radiolabeled Gold Nanoseeds Decorated with Substance P Peptides: Synthesis, Characterization and In Vitro Evaluation in Glioblastoma Cellular Models". International Journal of Molecular Sciences 23 2 (2022): 617. http://dx.doi.org/10.3390/ijms23020617.
    10.3390/ijms23020617
  5. D'Onofrio, Alice; Gano, Lurdes; Melo, Rita; Mendes, Filipa; Oliveira, Maria Cristina; Denoël, Thibaut; Schaefer, Niklaus; et al. "Biological evaluation of new TEM1 targeting recombinant antibodies for radioimmunotherapy: In vitro, in vivo and in silico studies". European Journal of Pharmaceutics and Biopharmaceutics 158 (2021): 233-244. http://dx.doi.org/10.1016/j.ejpb.2020.11.015.
    10.1016/j.ejpb.2020.11.015
  6. Oliveira, Maria Cristina; Correia, João D.G.. "Biomedical applications of radioiodinated peptides". European Journal of Medicinal Chemistry 179 (2019): 56-77. http://dx.doi.org/10.1016/j.ejmech.2019.06.014.
    10.1016/j.ejmech.2019.06.014
  7. Di Maria, S.; Belchior, A.; Pereira, E.; Quental, L.; Oliveira, M.C.; Mendes, F.; Lavrado, J.; Paulo, A.; Vaz, P.. "Dosimetry assessment of DNA damage by Auger-emitting radionuclides: Experimental and Monte Carlo studies". Radiation Physics and Chemistry 140 (2017): 278-282. http://dx.doi.org/10.1016/j.radphyschem.2017.01.028.
    10.1016/j.radphyschem.2017.01.028
  8. Morais, Maurício; Zamora-Carreras, Héctor; Raposinho, Paula; Oliveira, Maria; Pantoja-Uceda, David; Correia, João; Jiménez, M.. "NMR Insights into the Structure-Function Relationships in the Binding of Melanocortin Analogues to the MC1R Receptor". Molecules 22 7 (2017): 1189. http://dx.doi.org/10.3390/molecules22071189.
    10.3390/molecules22071189
  9. Pereira, Edgar; do Quental, Letícia; Palma, Elisa; Oliveira, Maria Cristina; Mendes, Filipa; Raposinho, Paula; Correia, Isabel; et al. "Evaluation of Acridine Orange Derivatives as DNA-Targeted Radiopharmaceuticals for Auger Therapy: Influence of the Radionuclide and Distance to DNA". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/srep42544.
    10.1038/srep42544
  10. Morais, G.R.; Palma, E.; Marques, F.; Gano, L.; Oliveira, M.C.; Abrunhosa, A.; Miranda, H.V.; et al. "Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents". Journal of Heterocyclic Chemistry 54 1 (2017): 255-267. http://www.scopus.com/inward/record.url?eid=2-s2.0-84952673515&partnerID=MN8TOARS.
    10.1002/jhet.2575
  11. Jasem, Yosef Al; Thiemann, Thies; Gano, Lurdes; Oliveira, Maria Cristina. "Fluorinated steroids and their derivatives". Journal of Fluorine Chemistry 185 (2016): 48-85. http://dx.doi.org/10.1016/j.jfluchem.2016.03.009.
    10.1016/j.jfluchem.2016.03.009
  12. Oliveira, Maria Cristina; Gano, Lurdes; Santos, Isabel; Correia, João D. G.; Serrano, Isa D.; Santos, Sónia Sá; Ribeiro, Marta; et al. "Improvement of the pharmacological properties of amidated kyotorphin by means of iodination". MedChemComm 7 5 (2016): 906-913. http://dx.doi.org/10.1039/c6md00028b.
    10.1039/c6md00028b
  13. Vultos, Filipe; Cunha, Susana; Fernandes, Célia; Oliveira, Maria Cristina; Marques, Fernanda; Botelho, Maria Filomena; Santos, Isabel; Gano, Lurdes. "New estradiol based 111In complex towards the estrogen receptor". Radiochimica Acta 103 11 (2015): 765-776. http://dx.doi.org/10.1515/ract-2014-2355.
    10.1515/ract-2014-2355
  14. Nunes, Patrique; Morais, Goreti Ribeiro; Palma, Elisa; Silva, Francisco; Oliveira, Maria Cristina; Ferreira, Vera F. C.; Mendes, Filipa; et al. "Isostructural Re(i)/99mTc(i) tricarbonyl complexes for cancer theranostics". Organic & Biomolecular Chemistry 13 18 (2015): 5182-5194. http://dx.doi.org/10.1039/c5ob00124b.
    10.1039/c5ob00124b
  15. C. Rodrigues; M. C. Oliveira. "Radioimunoterapia: uma abordagem terapêutica promissora no tratamento do carcinoma do ovário". Saúde & Tecnologia 14 (2015): 26-35. http://dx.doi.org/10.25758/set.1244.
  16. Isabel Santos; Cristina Oliveira; Letícia A. Quental; Goreti Ribeiro Morais; António Paulo. "Hidratos de Carbono Radiofluorados para Imagiologia Nuclear". Boletim da Sociedade Portuguesa de Química (2014): 41. http://dx.doi.org/10.52590/m3.p663.a30001884.
    10.52590/m3.p663.a30001884
  17. Cunha, Susana; Gano, Lurdes; Ribeiro Morais, Goreti; Thiemann, Thies; Oliveira, Maria Cristina. "Progesterone receptor targeting with radiolabelled steroids: An approach in predicting breast cancer response to therapy". The Journal of Steroid Biochemistry and Molecular Biology 137 (2013): 223-241. http://dx.doi.org/10.1016/j.jsbmb.2013.04.003.
    10.1016/j.jsbmb.2013.04.003
  18. Morais, Maurício; Oliveira, Bruno L.; Correia, João D. G.; Oliveira, Maria Cristina; Jiménez, Maria Angeles; Santos, Isabel; Raposinho, Paula D.. "Influence of the Bifunctional Chelator on the Pharmacokinetic Properties of 99mTc(CO)3-Labeled Cyclic a-Melanocyte Stimulating Hormone Analog". Journal of Medicinal Chemistry 56 5 (2013): 1961-1973. http://dx.doi.org/10.1021/jm301647t.
    10.1021/jm301647t
  19. Oliveira, M.C.; Neto, C.; Ribeiro Morais, G.; Thiemann, T.; Morais, G.R.. "Steroid Receptor Ligands for Breast Cancer Targeting: An Insight into Their Potential Role As Pet Imaging Agents". Current Medicinal Chemistry 20 2 (2013): 222-245. http://dx.doi.org/10.2174/092986713804806658.
    10.2174/092986713804806658
  20. Neto, Carina; Oliveira, Maria Cristina; Gano, Lurdes; Marques, Fernanda; Yasuda, Takumi; Thiemann, Thies; Kniess, Torsten; Santos, Isabel. "Novel 7a-alkoxy-17a-(4'-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumours: Synthesis and binding affinity evaluation". Steroids 77 11 (2012): 1123-1132. http://dx.doi.org/10.1016/j.steroids.2012.05.004.
    10.1016/j.steroids.2012.05.004
  21. Morais, Maurício; Raposinho, Paula D.; Oliveira, Maria Cristina; Pantoja-Uceda, David; Jiménez, Maria Angeles; Santos, Isabel; Correia, João D. G.. "NMR Structural Analysis of MC1R-Targeted Rhenium(I) Metallopeptides and Biological Evaluation of 99mTc(I) Congeners". Organometallics 31 16 (2012): 5929-5939. http://dx.doi.org/10.1021/om300502n.
    10.1021/om300502n
  22. Neto, Carina; Oliveira, Maria Cristina; Gano, Lurdes; Marques, Fernanda; Thiemann, Thies; Santos, Isabel. "Novel estradiol based metal complexes of Tc-99m". Journal of Inorganic Biochemistry 111 (2012): 1-9. http://dx.doi.org/10.1016/j.jinorgbio.2012.03.001.
    10.1016/j.jinorgbio.2012.03.001
  23. Cristina Oliveira, Maria; Neto, Carina; Gano, Lurdes; Marques, Fernanda; Santos, Isabel; Thiemann, Thies; Cristina Santos, Ana; Botelho, Filomena; F. Oliveira, Carlos. "Estrogen Receptor Ligands for Targeting Breast Tumours: A Brief Outlook on Radioiodination Strategies". Current Radiopharmaceuticalse 5 2 (2012): 124-141. http://dx.doi.org/10.2174/1874471011205020124.
    10.2174/1874471011205020124
  24. Kuchar, Manuela; Oliveira, Maria Cristina; Gano, Lurdes; Santos, Isabel; Kniess, Torsten. "Radioiodinated sunitinib as a potential radiotracer for imaging angiogenesis—radiosynthesis and first radiopharmacological evaluation of 5-[125I]Iodo-sunitinib". Bioorganic & Medicinal Chemistry Letters 22 8 (2012): 2850-2855. http://dx.doi.org/10.1016/j.bmcl.2012.02.068.
    10.1016/j.bmcl.2012.02.068
  25. Morais, Maurício; Raposinho, Paula D.; Oliveira, Maria Cristina; Correia, João D. G.; Santos, Isabel. "Evaluation of novel 99mTc(I)-labeled homobivalent a-melanocyte-stimulating hormone analogs for melanocortin-1 receptor targeting". JBIC Journal of Biological Inorganic Chemistry 17 4 (2012): 491-505. http://dx.doi.org/10.1007/s00775-011-0871-y.
    10.1007/s00775-011-0871-y
  26. Neto, C.; Fernandes, C.; Oliveira, M.C.; Gano, L.; Mendes, F.; Kniess, T.; Santos, I.; et al. "Radiohalogenated 4-anilinoquinazoline-based EGFR-TK inhibitors as potential cancer imaging agents". Nuclear Medicine and Biology 39 2 (2012): 247-260. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856346831&partnerID=MN8TOARS.
    10.1016/j.nucmedbio.2011.09.001
  27. Oliveira, Cristina; Morais, Goreti Ribeiro; Imai, Masao; Inohae, Eiko; Yamamoto, Chishou; Mataka, Shuntaro; Thiemann, Thies. "Acid Catalysed Reaction of Estrones with Neopentyl Glycol under Forced Conditions". Journal of Chemical Research 34 3 (2010): 158-162. http://dx.doi.org/10.3184/030823410x12678785299942.
    10.3184/030823410x12678785299942
  28. Raposinho, Paula D.; Correia, João D. G.; Oliveira, Maria Cristina; Santos, Isabel; Raposinho, P.D.; Correia, J.D.; Oliveira, M.C.; Santos, I.. "Melanocortin-1 receptor-targeting with radiolabeled cyclic a-melanocyte-stimulating hormone analogs for melanoma imaging". Biopolymers 94 6 (2010): 820-829. http://dx.doi.org/10.1002/bip.21490.
    10.1002/bip.21490
  29. Neto, C.; Oliveira, M.C.; Gano, L.; Marques, F.; Santos, I.; Morais, G.; Yasuda, T.; et al. "Evaluation of novel radioiodinated C7-substituted 6,7-estradiol derivatives for molecular recognition of ER-positive breast tumours". 2 2 (2009): 83-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-68149090478&partnerID=MN8TOARS.
    10.2174/1874471010902020083
  30. Neto, C.; Oliveira, M.C.; Gano, L.; Marques, F.; Santos, I.; Morais, G.R.; Yasuda, T.; et al. "Radioiodinated ligands for the estrogen receptor: Effect of different 7-cyanoalkyl chains on the binding affinity of novel iodovinyl-6-dehydroestradiols". 67 2 (2009): 301-307. http://www.scopus.com/inward/record.url?eid=2-s2.0-58049153116&partnerID=MN8TOARS.
    10.1016/j.apradiso.2008.10.005
  31. Yasuda, T.; Shima, Y.; Ideta, K.; Das Neves Oliveira, C.; Thiemann, T.. "7a-Alkoxyestra-1,3,5(10)-trienes". Journal of Chemical Research 1 (2008): 32-37. http://www.scopus.com/inward/record.url?eid=2-s2.0-42349097797&partnerID=MN8TOARS.
    10.3184/030823408X287140
  32. Morais, Goreti Ribeiro; Yoshioka, Naho; Watanabe, Masataka; Mataka, Shuntaro; Oliveira, Cristina das Neves; Thiemann, Thies. "C7-Substituted Estranes and Related Steroids". ChemInform 38 16 (2007): http://dx.doi.org/10.1002/chin.200716242.
    10.1002/chin.200716242
  33. Fernandes, C.; Oliveira, C.; Gano, L.; Bourkoula, A.; Pirmettis, I.; Santos, I.. "Radioiodination of new EGFR inhibitors as potential SPECT agents for molecular imaging of breast cancer". Bioorganic and Medicinal Chemistry 15 12 (2007): 3974-3980. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247846160&partnerID=MN8TOARS.
    10.1016/j.bmc.2007.04.008
  34. Thiemann, Thies; M., G.; Neves Oliveira, Maria. "Synthesis of C7-Substituted Estra-1,3,5(10),6-Tetraen-3,17 β-Diols". Letters in Organic Chemistry 3 3 (2006): 214-219. http://dx.doi.org/10.2174/157017806775789796.
    10.2174/157017806775789796
  35. Oliveira, M.C.; Videira, M.; Almeida, A.; Gano, L.; Watanabe, M.; Thiemann, T.; Santos, A.C.; et al. "Synthesis and biodistribution studies of two novel radioiodinated areno-annelated estra-1,3,5(10), 16-tetraene-3-ols as promising estrogen receptor radioligands". Journal of Labelled Compounds and Radiopharmaceuticals 49 6 (2006): 559-569. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745609761&partnerID=MN8TOARS.
    10.1002/jlcr.1076
  36. Morais, G.R.; Yoshioka, N.; Watanabe, M.; Mataka, S.; das Neves Oliveira, C.; Thiemann, T.. "C7-Substituted estranes and related steroids". Mini-Reviews in Organic Chemistry 3 3 (2006): 229-251. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746894571&partnerID=MN8TOARS.
  37. Wanga, Jian; Watanabe, Masataka; Mataka, Shuntaro; Thiemann, Thies; Morais, Goreti Ribeiro; Roleira, Fernanda; Silva, Elisiario Tavares da; Silva, Cristina Melo e. "Synthesis and Radiosynthesis of 17a-[p-(Iodophenylethynyl)]estra-3,17ß-diols". Zeitschrift für Naturforschung B 58 8 (2003): 799-804. http://dx.doi.org/10.1515/znb-2003-0813.
    10.1515/znb-2003-0813
  38. Dongol, Krishna Gopal; Melo e Silva, M. Cristina; Matsubara, Kouki; Matsumoto, Taisuke; Mataka, Shuntaro; Thiemann, Thies. "Zeitschrift für anorganische und allgemeine Chemie". Zeitschrift für anorganische und allgemeine Chemie 629 6 (2003): 945-947. http://dx.doi.org/10.1002/zaac.200300017.
    10.1002/zaac.200300017
  39. Melo e Silva, M.Cristina; Patri´cio, Luciana; Gano, Lurdes; Sá e Melo, M.Lui´sa; Inohae, Eiko; Mataka, Shuntaro; Thiemann, Thies. "Synthesis and biological evaluation of two new radiolabelled estrogens: [125I](E)-3-methoxy-17a-iodovinylestra-1,3,5(10),6-tetraen-17ß-ol and [125I](Z)-3-methoxy-17a-iodovinylestra-1,3,5(10),6-tetraen-17ß-ol". Applied Radiation and Isotopes 54 2 (2001): 227-239. http://dx.doi.org/10.1016/s0969-8043(99)00258-4.
    10.1016/s0969-8043(99)00258-4
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/10/23 Radiolabelled Gold Nanoparticles for Image-guided Chemoradiotherapy of Glioblastoma Multiforme
(lisboa, Portugal)
2019/07 Molecular and Nanosized Radioconjugates for Cancer Theranostics
(Lisboa, Portugal)
2019/07 Gold Nanoparticles for Image-Guided Delivery of Pt(IV) Prodrugs
(funchal, Portugal)
2018/04 Biological Assessment of a Radiolabelled LXXLL-Peptide for Breast Cancer Theranostics. 19th European Symposium on Radiopharmacy and Radiopharmaceuticals
(Groningen, Netherlands)
2018 Clickable radioimmunoconjugates: Theranostic agents for TEM1 pre-targeting MEDICIS Promed Final Conference
(Italy)
2014/05/25 Novel 111In-estradiol based complexes for oestrogen receptor targeting 17th European Symposium on Radiopharmacy and Radiopharmaceuticals
European Association of Nuclear Medicine (Pamplona, Spain)
2013/12 Complexos de 111In derivados de estradiol: avaliação pré-clínica para o diagnóstico do cancro da mama,
(porto, Portugal)
2009 Avaliação do potencial clínico de novos radioligandos para o receptor estrogénico em diagnóstico e/ou terapia: resultados finais. CIMAGO Meeting, HUC
CIMAGO (Coimbra, Portugal)
2007/11 Novel Biomarkers for Molecular Imaging of EGFR Positive Tumors
(Porto)
2001/12 Monitorização da Síntese e Purificação de Derivados beta-funcionalizados do tamoxifen por HPLC. 2º Encontro Nacional de Cromatografia
Sociedade Portuguesa de Química (lisboa, Portugal)
1999/12/13 Hormonas Esteróides Radioiodadas com Interesse Biomédico: Síntese Química e Purificação por HPLC 1º Encontro Nacional de Cromatografia
Sociedade Portuguesa de Química (Lisboa)
1999/11/12 Análogos do Estradiol na Detecção de Tumores da Mama: Estudo da Relação Estrutura Química-Actividade Biológica VI Curso de Divulgação de Medicina Nuclear/ A Medicina Nuclear e o Futuro
Instituto Português de Oncologia (lisboa, Portugal)
1999/03/28 Synthesis and Biodistribution of Potential Radiopharmaceutica as Diagnostica for Estrogen Positive Breast Cancer 76th National Meeting of the Japanese Chemical Society
(Yokohama, Japan)
1998/07 Synthesis and Biodistribution of Potential Radiopharmaceuticals for Estrogen Positive Breast Cancers 25th Kuju Symposium, Kuju, Japão
(Kuju, Japan)
1997/10/24 Estereoisómeros do 17alpha- 125I Iodovinyl-6-desidroestradiol-3-metil-éter: Potenciais Radioligandos para Visualização de Receptores de Estrogénios
(Lisboa)
1997/10 17alpha-125I Iodovinylsteroids Substituted at 7alpha: Investigation of a New Series of Iodine-125I-Labelled estrogens as Potential Imaging Agents for Estrogen Receptor positive Breast Cancers Chemistry Meeting
Instituto de Quimica Orgânica/Hannover University (Hannover, Germany)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2021 - Current Exploring the role of androgen receptor-targeting peptides in the early detection of triple negative breast cancers.
Co-supervisor
 Engenharia Química (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019 - 2019 Iodination and radioiodination of novel acridine orange derivatives as DNA-targeted radiopharmaceuticals for Auger therapy
Co-supervisor
Universidade de Lisboa Instituto Superior Tecnico Campus Tecnológico e Nuclear, Portugal
2018 - 2019 UC Ensino e divulgação científica / Programa Doutoral em Quimica do IST
Co-supervisor
 Programa doutoral em Quimica (2018-2019) (Other)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007 - 2011 Sondas Radioactivas Dirigidas a Receptores do Factor de Crescimento Epidérmico e a Receptores Estrogénico
Co-supervisor
2005 - 2005 Estrogénios radioiodados para diagnóstico e terapia de tumores da mama
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020/06/26 Steroid-BODIPY theranostics: Receptor mediated cell uptake and applications in cancer diagnostics and therapy
(Thesis) Main arguer
 Ana Filipa Patrício Amendoeira (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/10/30 Compostos Radioiodados para Terapia Auger
(Thesis) Arguer
 Edgar Pereira (Master)
Universidade NOVA de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2015/05/22 Avaliação do Potencial Clínico de Novos Ligandos para o Receptor Estrogénico em Diagnóstico e Terapia de Tumores da Mama
Thesis Member
 Susana Cunha. (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/11 Sondas Radioactivas Dirigidas a Receptores do Factor de Crescimento Epidérmico e a Receptores Estrogénicos,
Supervisor
 Carina Sofia Rosa Neto (PhD)
Universidade de Lisboa Faculdade de Ciências, Portugal
2011/06 Synthetic Modifications of Estrogens and Androgens
(Thesis) Main arguer
 Somdatta Deb (PhD)
Helsingin yliopisto, Finland
2006/09 Novel Steroidal Derivatives linked to Biologically Active Moieties
Thesis Member
 Goreti de Jesus Ribeiro Morais (PhD)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2021 - 2021 Cancers
2018 - 2018 New Journal of Chemistry
2018 - 2018 Medicinal Chemistry
2017 - 2017 Anti-Cancer agents in Medicinal Chemistry
2015 - 2015 Mini-Reviews in Medicinal Chemistry
2012 - 2014 Molecules
2013 - 2013 International Journal of Nanomedicine
2012 - 2012 Letters in Drug Design & Discovery
2012 - 2012 Cellular & Molecular Biology Letters
2012 - 2012 Nuclear Medicine and Biology
2010 - 2010 Journal of Labelled Compounds and Radiopharmaceuticals
2009 - 2009 Pharmacological Research

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021 - 2021 Estágio em Imagem Médica e Radioterapia IV / Síntese de 125I-Tyr4-BBN para determinação da afinidade de ligação de nanopartículas de ouro funcionalizadas com análogos da BBN a recetores do péptido libertador da Gastrina Imagem Médica e Radioterapia (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2021 - 2021 Estágio em Imagem Médica e Radioterapia V / Síntese de 125I- Tyr8-Substância P para a determinação da afinidade de ligação de nanoparticulas de ouro funcionalizadas com análogos da substância P a recetores da neurocinina-1 Imagem Médica e Radioterapia (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2021 - 2021 UC Radioquímica/ Práticas laboratoriais / Marcação com 125I . Purificação de moléculas radioiodadas Proteção e Segurança Radiológica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/02 - 2017/06 Estágio em Medicina Nuclear III / Marcação de Fragmentos de Anticorpos com 125I Medicina Nuclear (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2015/09 - 2015/12 Estágio em Medicina Nuclear II / Aplicação da terapia com radionuclídeos emissors de electrões Auger no carcinoma da prostata: 125I-DCIBzL Medicina Nuclear (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2015/02 - 2015/06 Estágio em Medicina Nuclear III / 18F-FES PET: Da química à clínica Medicina Nuclear (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2014/09 - 2014/12 Estágio em Medicina Nuclear II / Nanopartículas marcadas com radiohalogéneos para diagnóstico em Medicina Nuclear Medicina Nuclear (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2014/02 - 2014/07 Estágio em Medicina Nuclear III / Cancro do ovário: Diagnóstico e Terapêutica . Medicina Nuclear (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2013/02 - 2013/06 Estágio em Medicina Nuclear III / Ligandos com afinidade para as placas ß-Amilóide: marcação com 125I Medicina Nuclear (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2011 - 2012 Mestrado em Medicina Nuclear / Rádiofármacos com Aplicação em Tomografia por Emissão de Positrões (PET) Medicina Nuclear (Mestrado) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2006 - 2006 Investigação Aplicada em Medicina Nuclear II / Estudo do comportamento biológico da eritropoietina marcada com iodo-125 em modelo animal Medicina Nuclear (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
2005 - 2005 Licenciatura em Química Tecnológica / Estágio Profissionalizante Química Tecnológica (Licenciatura) Universidade de Lisboa Faculdade de Ciências, Portugal
2005 - 2005 Investigação Aplicada em Medicina Nuclear II/ Optimização do Método de Marcação da Eritropoietina com 125I. Avaliação in vitro e in vivo Medicina Nuclear (Licenciatura) Instituto Politécnico de Lisboa Escola Superior de Tecnologia da Saúde de Lisboa, Portugal
1983 - 1985 Licenciatura em Engenharia Química / Introdução a Técnicas Laboratoriais Engenharia Quimica (Licenciatura) Universidade da Beira Interior, Portugal
1983 - 1985 Licenciatura em Engenharia Química / Introdução a Engenharia Química Engenharia Química (Licenciatura) Universidade da Beira Interior, Portugal
1983 - 1985 Licenciatura em Engenharia Química / Química Orgânica I Engenharia Química (Licenciatura)

Journal scientific committee

Journal title (ISSN) Publisher
2006 - Current ARKIVOK