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I have graduated in Biochemistry by the University of Minho in 2013 and finished a master degree in Biochemistry at the University of Porto in 2015. During my masters I started my neuroscientist career within a project developed at IBMC (supervision of Márcia Liz and Carla Lopes), in the context of the neurogenerative disorder Transthyretin Amyloid Polyneuropathy (ATTR-PN) (Sci Rep 2020, 1st author; Best Poster award - XIV Meeting of the Portuguese Society for Neuroscience 2015). My growing interest in neurosciences encouraged me to pursue to a PhD (2017-2021). I obtained a scholarship through a competitive call from FCT (SFRH/BD/118728/2016) to develop my PhD thesis under the supervision of Márcia Liz (Neurodegeneration Team, Nerve Regeneration Group, IBMC/i3S, Porto) and co-supervision of Tiago Outeiro (University Medical Center Göttingen, Germany) and James Bamburg (Colorado State University, USA). My PhD project focused on actin cytoskeleton dysfunction in the context of PD with cognitive impairment (1st author: Front Cell Dev Biol 2020; Cell Death Dis 2024). During my PhD, I received a FLAD R&D@PhD fellowship allowing me a 4-month stay in James Bamburg's lab (JoVe 2017 co-author) and was supported by the Portugal-Germany Science Cooperation Programme (FCT-DAAD) to work in Tiago Outeiro's laboratory. Following my PhD, in 2022 I had a junior researcher contract supported by Creative Bio-Peptides Inc. to support the research in the context of CCR5 involvement in PD. In 2023, I received support from a Pfizer-funded grant, during which I worked on implementing the generation of neurons from iPS cells within the context of FAP. Currently, I am leading a project funded by a Pfizer's Global Medical Grants and starting a 6-year Junior Researcher contract from FCT.
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Identification

Personal identification

Full name
Marina Isabel Oliveira da Silva

Citation names

  • Oliveira da Silva, Marina Isabel

Author identifiers

Ciência ID
E319-898F-8C38
ORCID iD
0000-0002-8941-5805

Email addresses

  • marina.silva@ibmc.up.pt (Professional)

Telephones

Telephone
  • 220408800 Ext.: 6142 (Professional)

Addresses

  • Instituto de Investigação e Inovação em Saúde. Rua Alfredo Allen, 208, 4200-135, Porto, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2016 - 2021/09/14
Concluded
 Biologia Molecular e Celular (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"Actin dysfunction in neurodegenerative disorders: Uncovering Cofilin-1 pathology in Lewy Body dementias" (THESIS/DISSERTATION)
2021/07
Concluded
 Accreditation to work with small rodents (Outros)
Direcção-Geral de Alimentação e Veterinária, Portugal
2021
Concluded
 Intelletual Property Management Workshop (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016
Concluded
 Introductory course in Laboratory Animal Science following FELASA cat. B recommendations (Outros)
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2015
Concluded
 Bioquímica (Mestrado)
Major in Sem especialização
Universidade do Porto Faculdade de Ciências, Portugal
"Dissecting the role of cytoskeleton remodelling in a Drosophila model of TTR-induced neurodegeneration" (THESIS/DISSERTATION)
 18
2013
Concluded
 Bioquímica (Licenciatura)
Universidade do Minho, Portugal
"O papel dos macrófagos no estadio sacular do desenvolvimento pulmonar" (THESIS/DISSERTATION)
 16
Affiliation

Others

Category
Host institution 		Employer
2024/01/01 - Current Junior Researcher (Funding by Pfizer Inc.) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/01/01 - 2023/12/31 Junior Researcher (Funding by Pfizer Inc.) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/01/01 - 2022/12/31 Junior Researcher (Funding by Creative Bio-Peptides Inc.) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2016 - 2021/09/14 PhD Student Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2019/09/29 - 2019/10/12 Visiting PhD Student Universitätsmedizin Göttingen Abteilung Experimentelle Neurodegeneration, Germany
Universitätsmedizin Göttingen Abteilung Experimentelle Neurodegeneration, Germany
2018/11/04 - 2018/11/17 Visiting PhD Student Universitätsmedizin Göttingen Abteilung Experimentelle Neurodegeneration, Germany
2017/03/01 - 2017/06/30 Visiting PhD Student Colorado State University, United States
Colorado State University, United States
2015/10/01 - 2016/12/31 Research Fellow Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2014/09 - 2015/09 Master Student Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2012/04 - 2013/06 Research Intern Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Projects

Contract

Designation Funders
2024/09 - 2030/08 Novel therapeutics to synaptic dysfunction in Parkinson’s Disease: targeting CCR5 chemokine receptor
2023.08100.CEECIND/CP2844/CT0016
Principal investigator
Fundação para a Ciência e a Tecnologia
Ongoing
2024/01/01 - 2025/12/31 A human sensory neuron model to explore the pathophysiology of Transthyretin Amyloid Polyneuropathy
ID#87074543
Principal investigator
Pfizer Inc
Ongoing

Other

Designation Funders
2023/01/01 - 2023/12/31 Exploring axonal microtubule and mitochondrial transport defects in Transthyretin Amyloid Polyneuropathy (ATTR-PN)
67463999
Post-doc
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Pfizer Inc
2022/01/01 - 2022/12/31 Research Agreement with Creative Bio-Peptides Inc. Novel therapeutics to synaptic dysfunction in Parkinson’s Disease: targeting CCR5 chemokine receptor.
N/A
Post-doc
Creative Bio-Peptides Inc
2017/01/01 - 2022/03/31 Actin cytoskeleton disruption as a novel player in the pathogenesis of familial amyloid polyneuropathy: impact in the development of new therapeutic approaches
IF/00902/2015 50k€
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
2018 - 2021 Dissecting the actin cytoskeleton as novel therapeutic target in familial amyloid polyneuropathy
PTDC/MED-NEU/28336/2017
PhD Student Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2018 - 2019 Cofilin-actin rods as mediators of alpha-synuclein-induced synaptic dysfunction in Parkinson's disease
FCT/DAAD cooperation 2018/2019
PhD Student Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2019 Dissect the relevance of cytoskeleton alterations in the pathogenesis of amyloid-related disorders: familial amyloidotic polyneuropathy as a case study
NORTE-01-0145-FEDER-000008
PhD Student Fellow
2017 - 2018 Promoting Cytoskeleton Biology @IBMC
38/2017
PhD Student Fellow
Fundação Luso-Americana
Outputs

Publications

Conference abstract
  1. Magalhaes, Joana; Eira, Jéssica; Dias P. Vítor; Nóvoa, Guilherme; Oliveira da Silva, Marina Isabel; Yu-Yu Kan; Dias, A.; et al. Corresponding author: Liz, Márcia Almeida. "Rac1 activation triggers axonal cytoskeleton dysfunction in Transthyretin Amyloid Polyneuropathy". Paper presented in 2024 International Symposium on Amyloidosis, Rochester, Minnesota, 2024.
  2. J Magalhães, J Eira, G Nóvoa, MI Oliveira da Silva, V Dias, JP de Faria, AI Seixas, S-T Hsieh , MA Liz. "Axonal cytoskeleton alterations precede neurodegeneration in Transthyretin Amyloid Polyneuropathy". Paper presented in 2023 Peripheral Nerve Society Annual Meeting, Copenhagen, 2023.
  3. Oliveira da Silva, Marina Isabel. "Alpha-Synuclein induces cofilin pathology: implications on the molecular basis of Parkinson's disease". Paper presented in American Society for Cell Biology, San Diego, 2018.
  4. Oliveira da Silva, Marina Isabel. "Cofilin-actin rods as mediators of alpha-synuclein-induced synaptic dysfunction in Parkinson's disease". Paper presented in American Society for Cell Biology, Philadelphia, 2017.
Conference poster
  1. M. I. Oliveira da Silva, M. Santejo, I. W. Babcock, A. Magalhães, L. S. Minamide, SJ Won, E. Castillo, E. Gerhardt, C. F. "a-Synuclein induces cofilin pathology and dendritic spine impairment via a cellular prion protein (PrPC)/ chemokine receptor 5(CCR5)-dependent pathway". Paper presented in AD/PD™ 2024 Alzheimer's & Parkinson's Diseases Conference, 2024.
  2. J Magalhães, J Eira, G Nóvoa, MI Oliveira da Silva, V Dias, JP de Faria, AI Seixas, S-T Hsieh , MA Liz.. "Axonal cytoskeleton alterations precede neurodegeneration in Transthyretin Amyloid Polyneuropathy". Paper presented in 2023 Peripheral Nerve Society Annual Meeting, 2023.
  3. J Magalhães, J Eira, G Nóvoa, MI Oliveira da Silva, V Dias, JP de Faria, AI Seixas, S-T Hsieh , MA Liz. "Axonal cytoskeleton alterations precede neurodegeneration in Transthyretin Amyloid Polyneuropathy". Paper presented in EMBO workshop: Neural development and Neurodegeneration, 2022.
  4. J Magalhães, J Eira, G Nóvoa, MI Oliveira da Silva, V Dias, JP de Faria,AI Seixas,, S-T Hsieh, MA Liz. "Axonal cytoskeleton alterations precede neurodegeneration in Transthyretin Amyloid Polyneuropathy". Paper presented in EMBO: Neural development and neurodegeneration, 2022.
  5. Oliveira da Silva MI, Babcock IW, Santejo M, Minamide LS, Castillo E, Sawnson RA, Outeiro TF, Bamburg JR, Liz MA. "a-Synuclein induces cofilin pathology: implications for Parkinson's disease dementia". Paper presented in Cell Bio Virtual 2020 - Online ASCB/EMBO Meeting, 2020.
  6. Oliveira da Silva MI, Babcock IW, Santejo M, Minamide LS, Castillo E, Sawnson RA, Outeiro TF, Bamburg JR, Liz MA. "Alpha-Synuclein induces hippocampal cofilin pathology, through CXCR4/CCR5 and PrPC/NOX pathways, leading to spine impairment". Paper presented in CSHL, 2020.
  7. Oliveira da Silva MI, Santejo M, Swanson RA Outeiro TF , Bamburg JR, Liz MA. "a-Synuclein induces cofilin pathology: implications on Parkinson's disease dementia". Paper presented in i3S Annual Meeting, 2019.
  8. Oliveira da Silva MI, Santejo M, Outeiro TF, Bamburg JR, Liz MA. "a-Synuclein induces cofilin pathology: implications on Parkinso's disease dementia". Paper presented in Synuclein Meeting 2019: Where we are and where we need to go, 2019.
  9. Oliveira da Silva MI, Outeiro TF, Bamburg JR, Liz MA. "a-Synuclein induces cofilin pathology: implications on the molecular basis of Parkinson's disease". Paper presented in ASCB/EMBO, 2018.
  10. Oliveira da Silva MI, Outeiro TF, Bamburg JR, Liz MA. "Cofilin-actin rods as mediators of a-synuclein-induced synaptic dysfunction in Parkinson´s disease". Paper presented in ASCB/EMBO, 2017.
  11. Oliveira da Silva MI. "Dissecting the impact of amyloidogenic TTR in neuronal cytoskeleton using a fly model". Paper presented in 2016 Portuguese Drosophila Meeting, 2016.
  12. Oliveira da Silva MI. "Dissecting the role of cytoskeleton remodelling in transthyretin-induced neurodegeneration in a Drosophila model". Paper presented in XIV Meeting of the Portuguese Society for Neuroscience, 2015.
Journal article
  1. Oliveira da Silva, Marina I.; Santejo, Miguel; Babcock, Isaac W.; Magalhães, Ana; Minamide, Laurie S.; Won, Seok-Joon; Castillo, Erika; et al. "a-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway". Cell Death & Disease 15 4 (2024): http://dx.doi.org/10.1038/s41419-024-06630-9.
    10.1038/s41419-024-06630-9
  2. I. Oliveira da Silva, Marina; Lopes, Carla S.; Liz, Márcia A.. "Transthyretin interacts with actin regulators in a Drosophila model of familial amyloid polyneuropathy". Scientific Reports 10 1 (2020): http://dx.doi.org/10.1038/s41598-020-70377-4.
    Published • 10.1038/s41598-020-70377-4
  3. Oliveira da Silva, Marina I.; Liz, Márcia A.. "Linking Alpha-Synuclein to the Actin Cytoskeleton: Consequences to Neuronal Function". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00787.
    Published • 10.3389/fcell.2020.00787
  4. Oliveira da Silva, Marina Isabel; et al. "Modified Roller Tube Method for Precisely Localized and Repetitive Intermittent Imaging During Long-term Culture of Brain Slices in an Enclosed System.". Journal of visualized experiments : JoVE (2017): http://europepmc.org/articles/PMC5786369.
    Published • 10.3791/56436
Preprint
  1. Joana Magalhães; Vítor Dias; Jessica Eira; Guilherme Nóvoa; Marina I. Oliveira da Silva; Yu Yu Kan; Andreia Dias; et al. "Rac1 inhibition prevents axonal cytoskeleton dysfunction in Transthyretin Amyloid Polyneuropathy". 2024. https://doi.org/10.1101/2024.11.27.625664.
    10.1101/2024.11.27.625664
Thesis / Dissertation
  1. "Actin dysfuntion in neurodegenrative disorders: Uncovering cofilin-1 pathology in Lewy Body dementias.". PhD, Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, 2021.
  2. Oliveira da Silva, Marina Isabel. "Dissecting the role of cytoskeleton remodelling in a Drosophila model of TTR-induced neurodegeneration". Master, Universidade do Porto Faculdade de Ciências, 2015.

Other

Other output
  1. Cofilin pathology is a new player on a-synuclein-induced spine impairment in models of hippocampal synucleinopathy. 2021. MI Oliveira da Silva; M Santejo; IW Babcock; A Magalhães; LS Minamide; E Castillo; E Gerhardt; et al. https://doi.org/10.1101/2021.02.02.425931.
    10.1101/2021.02.02.425931
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2025/02/19 a-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway X Bioengineering week
IST, Lisbon (Lisbon, Portugal)
2024/04/18 RoundTable: A decade building Science: What happens after your PhD? 10th McBiology Symposium
(Porto, Portugal)
2024/03/13 The molecular mechanisms behind dementia. RoundTable: "Memory's Pathways: A Conversation with Alzheimer's" VI Jornadas Ibéricas de Genética e Biotecnologia - UTAD
(Vila Real, Portugal)
2021/03 Alpha-Synuclein induces cofilin patholgy: implications for Parkinson's disease dementia ADPD 2021 - The 15th International Conference on Alzheimer's and Parkinson's Disease
(Virtual)
2019/11/06 a -Synuclein induces cofilin pathology: implications on Parkinson's disease dementia 6th MCBiology Symposium at i3S
Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2019/09/26 a -Synuclein induces cofilin pathology: implications on Parkinson's disease dementia 2nd PhDay at i3S
Instituto de Investigação e Inovação em Saúde (Porto, Portugal)
2017/11 Cofilin-actin rods as mediators of a-synuclein-induced synaptic dysfunction in Parkinson’s dementia - Short Communication i3S Annual Meeting 2017
Instituto de Investigação e Inovação em Saúde (Póvoa de Varzim, Portugal)
2016/11 Dissecting the impact of amyloidogenic TTR in neuronal cytoskeleton using a fly model - Short Communication 5th i3S Annual Meeting
Instituto de Investigação e Inovação em Saúde (Póvoa de Varzim, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019 - 2019 2nd PhDay | PhD countdown: a time for Science (2019/09/29 - 2019/09/29)
Symposium (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2016 - 2016 2nd Annual MCBiology Symposium: Orchestrating life, from molecules to cells (2016/11/26 - 2016/11/26)
Symposium (Member of the Organising Committee)
 Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012 - 2012 III Jornadas de Bioquímica "Viagem entre dois mundos". (2012/03/26 - 2012/03/27)
Symposium (President of the Organising Committee)
 Universidade do Minho, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2016 - Current Porto de Crianças: "À descoberta do cérebro". Câmara Municipal do Porto.
Other
2024/11/26 - 2024/12/17 Research Project Management 4th Edition
Workshop
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/06/14 Characterization of the neuroprotective effect of anti-aggregation molecules in a Drosophila model of Machado-Joseph Disease
(Thesis) Main arguer
 Ana Mafalda Claro (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2022/07/26 The role of L-DOPA decarboxylase on neurite outgrowth and maintenance
(Thesis) Main arguer
 Sofia Miranda Fernandes (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2018 Vascular alterations in Alzheimer's Disease - a role for Transthyretin?
(Thesis) Main arguer
 Diana Martins Machado (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024/07/31 - Current Alzheimer's Research & Therapy Journal Springer Nature

Association member

Society Organization name Role
2024/02 - Current European Society for Clinical Investigation (ESCI) Association Member

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/02 Distinção "Investigador do mês" Prevenir

Mentoring / Tutoring

Topic Student name
2022/07 - 2023/09 Mestrado em Biomedicina Molecular Vitor Dias
2023/01 - 2023/07 Estágio voluntário - Mestrado integrado em Bioengenharia Andreia Silva
2021/09 - 2022/07 Mestrado em Bioquímica Guilherme Nóvoa
2019 - 2020/01/01 Impact of cofilin-actin rods formation on Parkinson’s Dementia - Mestrado em Bioquímica Miguel Santejo
2018 - 2018 Estágio Voluntário - BSc Ana Beatriz Ramos
2017 - 2017 Estágio Voluntário - BSc Daniela Marinho Lopes

Other jury / evaluation

Activity description Institution / Organization
2023/02/23 - 2033/02/24 Poster evaluator/Scientific committee at the 9th McBiology Symposium
Distinctions

Award

2024 Junior Researcher: 2023.08100.CEECIND - FCT Scientific Employment Stimulus
Fundação para a Ciência e a Tecnologia, Portugal
2017 R&D@PhD Internship Grant by FLAD
Fundação Luso-Americana, Portugal
2015 Best Poster award
Sociedade Portuguesa de Neurociências, Portugal

Other distinction

2017 FCT PhD Scholarship
Fundação para a Ciência e a Tecnologia, Portugal