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van Niel Guillaume. Published 48 articles in journals. Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Cell Biology, Medical and Health Sciences with emphasis on Basic Medicine with emphasis on Neurosciences and Natural sciences with emphasis on Biological Sciences with emphasis on Developmental Biology.
Identification

Personal identification

Full name
van Niel Guillaume

Citation names

  • Guillaume, van Niel

Author identifiers

Ciência ID
E31A-669E-0016
ORCID iD
0000-0002-8651-9705

Telephones

Telephone
  • (33) 1 40789236 (Professional)

Addresses

  • 102 rue de la Santé, 75014, Paris, Paris, France (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Developmental Biology

Languages

Language Speaking Reading Writing Listening Peer-review
French Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Dutch Elementary (A2) Intermediate (B1) Elementary (A2) Elementary (A2) Beginner (A1)
Education
Degree Classification
2003/04/02
Concluded
 Pathophysiology of human nutrition (Doctorat)
Major in cum Laude
Université de Paris UFR Sciences du Vivant, France
Affiliation

Science

Category
Host institution 		Employer
2017/03/01 - Current Principal Investigator (Research) Centre National de la Recherche Scientifique, France
Institut de Psychiatrie et Neurosciences de Paris, France
2008/10/01 - 2017/03/01 Researcher (Research) Centre National de la Recherche Scientifique, France
Institut Curie Centre de Recherche, France
2005/09/01 - 2008/09/30 Postdoc (Research) Institut Curie Centre de Recherche, France
2003/09/01 - 2005/08/31 Postdoc (Research) Universiteit Utrecht, Netherlands
Projects

Grant

Designation Funders
2020/01 - 2022/12 Contribution des exosomes à la progression des tumeurs gliales
INCA N°2019-125 PLBIO19-059 R19203KP RPT19203KKP U1266
 Institut National du Cancer
2020/01 - 2022/12 Suivi en temps réel et in vivo de la communication médiée par les exosomes lors de la progression de tumeurs gliales.
PGA1 RF20190208474
 Fondation ARC pour la Recherche sur Le Cancer
2017/03 - 2019/03 Role of endosomal dynamic in amyloid related neuropathies
AJE20160635884
 Fondation pour la Recherche Médicale
Outputs

Publications

Journal article
  1. Thouvenin, Olivier; Keiser, Ludovic; Cantaut-Belarif, Yasmine; Carbo-Tano, Martin; Verweij, Frederik; Jurisch-Yaksi, Nathalie; Bardet, Pierre-Luc; et al. "Origin and role of the cerebrospinal fluid bidirectional flow in the central canal". eLife 9 (2020): http://dx.doi.org/10.7554/elife.47699.
    10.7554/elife.47699
  2. Bebelman, Maarten P.; Bun, Philippe; Huveneers, Stephan; van Niel, Guillaume; Pegtel, D. Michiel; Verweij, Frederik J.. "Real-time imaging of multivesicular body–plasma membrane fusion to quantify exosome release from single cells". Nature Protocols 15 1 (2019): 102-121. http://dx.doi.org/10.1038/s41596-019-0245-4.
    10.1038/s41596-019-0245-4
  3. Russell, Ashley E.; Sneider, Alexandra; Witwer, Kenneth W.; Bergese, Paolo; Bhattacharyya, Suvendra N.; Cocks, Alexander; Cocucci, Emanuele; et al. "Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: an ISEV position paper arising from the ISEV membranes and EVs workshop". Journal of Extracellular Vesicles 8 1 (2019): 1684862. http://dx.doi.org/10.1080/20013078.2019.1684862.
    10.1080/20013078.2019.1684862
  4. Verweij, Frederik J.; Hyenne, Vincent; Van Niel, Guillaume; Goetz, Jacky G.. "Extracellular Vesicles: Catching the Light in Zebrafish". Trends in Cell Biology 29 10 (2019): 770-776. http://dx.doi.org/10.1016/j.tcb.2019.07.007.
    10.1016/j.tcb.2019.07.007
  5. Bissig, Christin; Croisé, Pauline; Heiligenstein, Xavier; Hurbain, Ilse; Lenk, Guy M.; Kaufman, Emily; Sannerud, Ragna; et al. "The PIKfyve complex regulates the early melanosome homeostasis required for physiological amyloid formation". Journal of Cell Science 132 5 (2019): jcs229500. http://dx.doi.org/10.1242/jcs.229500.
    10.1242/jcs.229500
  6. Verweij, Frederik J.; Revenu, Celine; Arras, Guillaume; Dingli, Florent; Loew, Damarys; Pegtel, D. Michiel; Follain, Gautier; et al. "Live Tracking of Inter-organ Communication by Endogenous Exosomes In Vivo". Developmental Cell 48 4 (2019): 573-589.e4. http://dx.doi.org/10.1016/j.devcel.2019.01.004.
    10.1016/j.devcel.2019.01.004
  7. Hyenne, Vincent; Ghoroghi, Shima; Collot, Mayeul; Bons, Joanna; Follain, Gautier; Harlepp, Sébastien; Mary, Benjamin; et al. "Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo". Developmental Cell 48 4 (2019): 554-572.e7. http://dx.doi.org/10.1016/j.devcel.2019.01.014.
    10.1016/j.devcel.2019.01.014
  8. Théry, Clotilde; Witwer, Kenneth W; Aikawa, Elena; Alcaraz, Maria Jose; Anderson, Johnathon D; Andriantsitohaina, Ramaroson; Antoniou, Anna; et al. "Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines". Journal of Extracellular Vesicles 7 1 (2018): 1535750. http://dx.doi.org/10.1080/20013078.2018.1535750.
    10.1080/20013078.2018.1535750
  9. Cesi, Giulia; Philippidou, Demetra; Kozar, Ines; Kim, Yeoun Jin; Bernardin, Francois; Van Niel, Guillaume; Wienecke-Baldacchino, Anke; et al. "A new ALK isoform transported by extracellular vesicles confers drug resistance to melanoma cells". Molecular Cancer 17 1 (2018): http://dx.doi.org/10.1186/s12943-018-0886-x.
    10.1186/s12943-018-0886-x
  10. Bergam, Ptissam; Reisecker, Johannes M.; Rakvács, Zsófia; Kucsma, Nóra; Raposo, Graça; Szakacs, Gergely; van Niel, Guillaume. "ABCB6 Resides in Melanosomes and Regulates Early Steps of Melanogenesis Required for PMEL Amyloid Matrix Formation". Journal of Molecular Biology 430 20 (2018): 3802-3818. http://dx.doi.org/10.1016/j.jmb.2018.06.033.
    10.1016/j.jmb.2018.06.033
  11. Nag, Sudeshna; Rani, Shikha; Mahanty, Sarmistha; Bissig, Christin; Arora, Pooja; Azevedo, Cristina; Saiardi, Adolfo; et al. "Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles". (2018):
    10.1242/jcs.216226
  12. Palmulli, Roberta; van Niel, Guillaume. "To be or not to be... secreted as exosomes, a balance finely tuned by the mechanisms of biogenesis". Essays in Biochemistry 62 2 (2018): 177-191. http://dx.doi.org/10.1042/ebc20170076.
    10.1042/ebc20170076
  13. Verweij, Frederik Johannes; Bebelman, Maarten P.; Jimenez, Connie R.; Garcia-Vallejo, Juan J.; Janssen, Hans; Neefjes, Jacques; Knol, Jaco C.; et al. "Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling". Journal of Cell Biology 217 3 (2018): 1157-1157. http://dx.doi.org/10.1083/jcb.20170320601192018c.
    10.1083/jcb.20170320601192018c
  14. van Niel, Guillaume; D'Angelo, Gisela; Raposo, Graça. "Shedding light on the cell biology of extracellular vesicles". Nature Reviews Molecular Cell Biology 19 4 (2018): 213-228. http://dx.doi.org/10.1038/nrm.2017.125.
    10.1038/nrm.2017.125
  15. Verweij FJ; Bebelman MP; Jimenez CR; Garcia-Vallejo JJ; Janssen H; Neefjes J; Knol JC; et al. "Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling.". The Journal of cell biology (2018): http://europepmc.org/abstract/med/29339438.
    10.1083/jcb.201703206
  16. Bissig, Christin; Hurbain, Ilse; Raposo, Graça; van Niel, Guillaume. "PIKfyve activity regulates reformation of terminal storage lysosomes from endolysosomes". Traffic 18 11 (2017): 747-757. http://dx.doi.org/10.1111/tra.12525.
    10.1111/tra.12525
  17. Elkhatib, Nadia; Bresteau, Enzo; Baschieri, Francesco; Rioja, Alba López; van Niel, Guillaume; Vassilopoulos, Stéphane; Montagnac, Guillaume. "Tubular clathrin/AP-2 lattices pinch collagen fibers to support 3D cell migration". Science 356 6343 (2017): eaal4713. http://dx.doi.org/10.1126/science.aal4713.
    10.1126/science.aal4713
  18. Barbazán, Jorge; Alonso-Alconada, Lorena; Elkhatib, Nadia; Geraldo, Sara; Gurchenkov, Vasily; Glentis, Alexandros; van Niel, Guillaume; et al. "Liver Metastasis Is Facilitated by the Adherence of Circulating Tumor Cells to Vascular Fibronectin Deposits". Cancer Research 77 13 (2017): 3431-3441. http://dx.doi.org/10.1158/0008-5472.can-16-1917.
    10.1158/0008-5472.can-16-1917
  19. Van Deun, Jan; Mestdagh, Pieter; Agostinis, Patrizia; Akay, Özden; Anand, Sushma; Anckaert, Jasper; Martinez, Zoraida Andreu; et al. "EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research". Nature Methods 14 3 (2017): 228-232. http://dx.doi.org/10.1038/nmeth.4185.
    10.1038/nmeth.4185
  20. Bissig, Christin; Rochin, Leila; van Niel, Guillaume. "PMEL Amyloid Fibril Formation: The Bright Steps of Pigmentation". International Journal of Molecular Sciences 17 9 (2016): 1438. http://dx.doi.org/10.3390/ijms17091438.
    10.3390/ijms17091438
  21. Sannerud, Ragna; Esselens, Cary; Ejsmont, Paulina; Mattera, Rafael; Rochin, Leila; Tharkeshwar, Arun Kumar; De Baets, Greet; et al. "Restricted Location of PSEN2/¿-Secretase Determines Substrate Specificity and Generates an Intracellular Aß Pool". Cell 166 1 (2016): 193-208. http://dx.doi.org/10.1016/j.cell.2016.05.020.
    10.1016/j.cell.2016.05.020
  22. van Niel, Guillaume. "Study of Exosomes Shed New Light on Physiology of Amyloidogenesis". Cellular and Molecular Neurobiology 36 3 (2016): 327-342. http://dx.doi.org/10.1007/s10571-016-0357-0.
    10.1007/s10571-016-0357-0
  23. Fais, Stefano; O’Driscoll, Lorraine; Borras, Francesc E.; Buzas, Edit; Camussi, Giovanni; Cappello, Francesco; Carvalho, Joana; et al. "Evidence-Based Clinical Use of Nanoscale Extracellular Vesicles in Nanomedicine". ACS Nano 10 4 (2016): 3886-3899. http://dx.doi.org/10.1021/acsnano.5b08015.
    10.1021/acsnano.5b08015
  24. van Niel, Guillaume; Bergam, Ptissam; Di Cicco, Aurelie; Hurbain, Ilse; Lo Cicero, Alessandra; Dingli, Florent; Palmulli, Roberta; et al. "Apolipoprotein E Regulates Amyloid Formation within Endosomes of Pigment Cells". Cell Reports 13 1 (2015): 43-51. http://dx.doi.org/10.1016/j.celrep.2015.08.057.
    10.1016/j.celrep.2015.08.057
  25. Cicero, Alessandra Lo; Delevoye, Cédric; Gilles-Marsens, Floriane; Loew, Damarys; Dingli, Florent; Guéré, Christelle; André, Nathalie; et al. "Exosomes released by keratinocytes modulate melanocyte pigmentation". Nature Communications 6 1 (2015): http://dx.doi.org/10.1038/ncomms8506.
    10.1038/ncomms8506
  26. Kiss, Katalin; Kucsma, Nora; Brozik, Anna; Tusnady, Gabor E.; Bergam, Ptissam; van Niel, Guillaume; Szakacs, Gergely. "Role of the N-terminal transmembrane domain in the endo-lysosomal targeting and function of the human ABCB6 protein". Biochemical Journal 467 1 (2015): 127-139. http://dx.doi.org/10.1042/bj20141085.
    10.1042/bj20141085
  27. Rajendran, L.; Bali, J.; Barr, M. M.; Court, F. A.; Kramer-Albers, E.-M.; Picou, F.; Raposo, G.; et al. "Emerging Roles of Extracellular Vesicles in the Nervous System". Journal of Neuroscience 34 46 (2014): 15482-15489. http://dx.doi.org/10.1523/jneurosci.3258-14.2014.
    10.1523/jneurosci.3258-14.2014
  28. Rajendran, L.; Bali, J.; Barr, M. M.; Court, F. A.; Kramer-Albers, E.-M.; Picou, F.; Raposo, G.; et al. "Emerging Roles of Extracellular Vesicles in the Nervous System". Journal of Neuroscience 34 46 (2014): 15482-15489. http://dx.doi.org/10.1523/jneurosci.3258-14.2014.
    10.1523/jneurosci.3258-14.2014
  29. Colombo, Marina; Moita, Catarina; van Niel, Guillaume; Kowal, Joanna; Vigneron, James; Benaroch, Philippe; Manel, Nicolas; et al. "Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles". Journal of Cell Science 126 24 (2013): 5553-5565. http://dx.doi.org/10.1242/jcs.128868.
    10.1242/jcs.128868
  30. Odintsova, Elena; van Niel, Guillaume; Conjeaud, Hélène; Raposo, Graça; Iwamoto, Ryo; Mekada, Eisuke; Berditchevski, Fedor. "Metastasis Suppressor Tetraspanin CD82/KAI1 Regulates Ubiquitylation of Epidermal Growth Factor Receptor". Journal of Biological Chemistry 288 36 (2013): 26323-26334. http://dx.doi.org/10.1074/jbc.m112.439380.
    10.1074/jbc.m112.439380
  31. Rochin, L.; Hurbain, I.; Serneels, L.; Fort, C.; Watt, B.; Leblanc, P.; Marks, M. S.; et al. "BACE2 processes PMEL to form the melanosome amyloid matrix in pigment cells". Proceedings of the National Academy of Sciences 110 26 (2013): 10658-10663. http://dx.doi.org/10.1073/pnas.1220748110.
    10.1073/pnas.1220748110
  32. Brouwers, Jos F.; Aalberts, Marian; Jansen, Jeroen W. A.; van Niel, Guillaume; Wauben, Marca H.; Stout, Tom A. E.; Helms, J. Bernd; Stoorvogel, Willem. "Distinct lipid compositions of two types of human prostasomes". PROTEOMICS 13 10-11 (2013): 1660-1666. http://dx.doi.org/10.1002/pmic.201200348.
    10.1002/pmic.201200348
  33. Watt, Brenda; van Niel, Guillaume; Raposo, Graça; Marks, Michael S.. "PMEL: a pigment cell-specific model for functional amyloid formation". Pigment Cell & Melanoma Research 26 3 (2013): 300-315. http://dx.doi.org/10.1111/pcmr.12067.
    10.1111/pcmr.12067
  34. Araldi, Elisa; Krämer-Albers, Eva-Maria; Hoen, Esther Nolte-‘t; Peinado, Hector; Psonka-Antonczyk, Katarzyna Maria; Rao, Pooja; van Niel, Guillaume; Yáñez-Mó, María; Nazarenko, Irina. "International Society for Extracellular Vesicles: first annual meeting, April 17–21, 2012: ISEV-2012". Journal of Extracellular Vesicles 1 1 (2012): 19995. http://dx.doi.org/10.3402/jev.v1i0.19995.
    10.3402/jev.v1i0.19995
  35. van Niel, Guillaume; Charrin, Stéphanie; Simoes, Sabrina; Romao, Maryse; Rochin, Leila; Saftig, Paul; Marks, Michael S.; Rubinstein, Eric; Raposo, Graça. "The Tetraspanin CD63 Regulates ESCRT-Independent and -Dependent Endosomal Sorting during Melanogenesis". Developmental Cell 21 4 (2011): 708-721. http://dx.doi.org/10.1016/j.devcel.2011.08.019.
    10.1016/j.devcel.2011.08.019
  36. ten Broeke, Toine; van Niel, Guillaume; Wauben, Marca H. M.; Wubbolts, Richard; Stoorvogel, Willem. "Endosomally Stored MHC Class II Does Not Contribute to Antigen Presentation by Dendritic Cells at Inflammatory Conditions". Traffic 12 8 (2011): 1025-1036. http://dx.doi.org/10.1111/j.1600-0854.2011.01212.x.
    10.1111/j.1600-0854.2011.01212.x
  37. Delevoye, Cédric; Giordano, Francesca; van Niel, Guillaume; Raposo, Graça. "La biogenèse des mélanosomes". médecine/sciences 27 2 (2011): 153-162. http://dx.doi.org/10.1051/medsci/2011272153.
    10.1051/medsci/2011272153
  38. Watt, Brenda; van Niel, Guillaume; Fowler, Douglas M.; Hurbain, Ilse; Luk, Kelvin C.; Stayrook, Steven E.; Lemmon, Mark A.; et al. "N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils". Journal of Biological Chemistry 284 51 (2009): 35543-35555. http://dx.doi.org/10.1074/jbc.m109.047449.
    10.1074/jbc.m109.047449
  39. Buschow, Sonja I.; Nolte-‘t Hoen, Esther N. M.; van Niel, Guillaume; Pols, Maaike S.; ten Broeke, Toine; Lauwen, Marjolein; Ossendorp, Ferry; et al. "MHC II in Dendritic Cells is Targeted to Lysosomes or T Cell-Induced Exosomes Via Distinct Multivesicular Body Pathways". Traffic 10 10 (2009): 1528-1542. http://dx.doi.org/10.1111/j.1600-0854.2009.00963.x.
    10.1111/j.1600-0854.2009.00963.x
  40. van Niel, Guillaume; Wubbolts, Richard; Stoorvogel, Willem. "Endosomal sorting of MHC class II determines antigen presentation by dendritic cells". Current Opinion in Cell Biology 20 4 (2008): 437-444. http://dx.doi.org/10.1016/j.ceb.2008.05.011.
    10.1016/j.ceb.2008.05.011
  41. Matysiak-Budnik, Tamara; Moura, Ivan Cruz; Arcos-Fajardo, Michelle; Lebreton, Corinne; Me´nard, Sandrine; Candalh, Ce´line; Ben-Khalifa, Karima; et al. "Secretory IgA mediates retrotranscytosis of intact gliadin peptides via the transferrin receptor in celiac disease". Journal of Experimental Medicine 205 1 (2007): 143-154. http://dx.doi.org/10.1084/jem.20071204.
    10.1084/jem.20071204
  42. Mallegol, Julia; Van Niel, Guillaume; Lebreton, Corinne; Lepelletier, Yves; Candalh, Céline; Dugave, Christophe; Heath, Joan K.; et al. "T84-Intestinal Epithelial Exosomes Bear MHC Class II/Peptide Complexes Potentiating Antigen Presentation by Dendritic Cells". Gastroenterology 132 5 (2007): 1866-1876. http://dx.doi.org/10.1053/j.gastro.2007.02.043.
    10.1053/j.gastro.2007.02.043
  43. van Niel, Guillaume; Wubbolts, Richard; ten Broeke, Toine; Buschow, Sonja I.; Ossendorp, Ferry A.; Melief, Cornelis J.; Raposo, Graca; van Balkom, Bas W.; Stoorvogel, Willem. "Dendritic Cells Regulate Exposure of MHC Class II at Their Plasma Membrane by Oligoubiquitination". Immunity 25 6 (2006): 885-894. http://dx.doi.org/10.1016/j.immuni.2006.11.001.
    10.1016/j.immuni.2006.11.001
  44. van Niel, Guillaume; Porto-Carreiro, Isabel; Simoes, Sabrina; Raposo, Graça. "Exosomes: A Common Pathway for a Specialized Function". The Journal of Biochemistry 140 1 (2006): 13-21. http://dx.doi.org/10.1093/jb/mvj128.
    10.1093/jb/mvj128
  45. Mallegol, J.; van Niel, G.; Heyman, M.. "Phenotypic and functional characterization of intestinal epithelial exosomes". Blood Cells, Molecules, and Diseases 35 1 (2005): 11-16. http://dx.doi.org/10.1016/j.bcmd.2005.04.001.
    10.1016/j.bcmd.2005.04.001
  46. Van Niel, G. "Intestinal epithelial exosomes carry MHC class II/peptides able to inform the immune system in mice". Gut 52 12 (2003): 1690-1697. http://dx.doi.org/10.1136/gut.52.12.1690.
    10.1136/gut.52.12.1690
  47. Matysiak-Budnik, Tamara; van Niel, Guillaume; Me´graud, Francis; Mayo, Kathryn; Bevilacqua, Claudia; Gaboriau-Routhiau, Vale´rie; Moreau, Marie-Christiane; Heyman, Martine. "Gastric Helicobacter Infection Inhibits Development of Oral Tolerance to Food Antigens in Mice". Infection and Immunity 71 9 (2003): 5219-5224. http://dx.doi.org/10.1128/iai.71.9.5219-5224.2003.
    10.1128/iai.71.9.5219-5224.2003
  48. Matysiak-Budnik T; van Niel G; Mégraud F; Mayo K; Bevilacqua C; Gaboriau-Routhiau V; Moreau MC; Heyman M. "Gastric Helicobacter infection inhibits development of oral tolerance to food antigens in mice.". (2003): http://europepmc.org/abstract/med/12933867.
    10.1128/IAI.71.9.5219-5224.2003
  49. van Niel, Guillaume; Heyman, Martine. "II. Intestinal epithelial cell exosomes: perspectives on their structure and function". American Journal of Physiology-Gastrointestinal and Liver Physiology 283 2 (2002): G251-G255. http://dx.doi.org/10.1152/ajpgi.00102.2002.
    10.1152/ajpgi.00102.2002
  50. van Niel G; Heyman M. "The epithelial cell cytoskeleton and intracellular trafficking. II. Intestinal epithelial cell exosomes: perspectives on their structure and function.". (2002): http://europepmc.org/abstract/med/12121870.
  51. Van Niel, Guillaume; Raposo, Graça; Candalh, Céline; Boussac, Muriel; Hershberg, Robert; Cerf–Bensussan, Nadine; Heyman, Martine. "Intestinal epithelial cells secrete exosome–like vesicles". Gastroenterology 121 2 (2001): 337-349. http://dx.doi.org/10.1053/gast.2001.26263.
    10.1053/gast.2001.26263

Other

Other output
  1. Origin of the bidirectionality of cerebrospinal fluid flow and impact on long-range transport between brain and spinal cord. 2019. Olivier Thouvenin; Ludovic Keiser; Yasmine Cantaut-Belarif; Martin Carbo-Tano; Frederik Verweij; Nathalie Jurisch-Yaksi; Pierre-Luc Bardet; et al. https://doi.org/10.1101/627166.
    10.1101/627166
Activities

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2020/04/01 Doctorate thesis Jury
Thesis Member
 13 candidates (PhD)

Association member

Society Organization name Role
2017/01/01 - Current French socitey of extracellular vesicles Co-Founder and vice presidente

Conference scientific committee

Conference name Conference host
2014/10/01 - Current EMBO advanced course, “Extracellular Vesicles: from Biology to Biomedical Applications”. EMBL Heidelberg