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João Filipe Alves de Amorim. Concluiu o(a) Mestrado em Cellular and Molecular Biology em 2014 pelo(a) Universidade de Coimbra Faculdade de Ciencias e Tecnologia e Licenciatura em Biochemistry em 2012 pelo(a) Universidade de Trás-os-Montes e Alto Douro. É Investigador no(a) Universidade de Coimbra. Publicou 7 artigos em revistas especializadas. Possui 2 capítulo(s) de livros. Organizou 1 evento(s). Recebeu 3 prémio(s) e/ou homenagens.
Identification

Personal identification

Full name
João Filipe Alves de Amorim

Citation names

  • Amorim, João

Author identifiers

Ciência ID
E417-60F5-C614
ORCID iD
0000-0002-7720-6264

Telephones

Mobile phone
  • (+1) 8572007840 (Personal)

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Proficiency (C2) Proficiency (C2) Advanced (C1) Proficiency (C2)
Education
Degree Classification
2015/12/01 - 2019/12/11
Concluded
 Biologia Experimental e Biomedicina (Doutoramento)
Major in Biologia Molecular, Celular e do Desenvolvimento
Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
 18
2012 - 2014
Concluded
 Biologia Celular e Molecular (Mestrado integrado)
Major in Neurociências
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mitochondria in glutamatergic nerve terminals are selectively affected by exposure to Aß1-42 modeling early Alzheimer's disease" (THESIS/DISSERTATION)
 18
2008 - 2012
Concluded
 Bioquímica (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"Effect of exposure to parabens, during the period of pregnancy, in renal antioxidant capacity of the F1 generation" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2020/01/01 - Current Postdoc (Research) Harvard Medical School Department of Genetics, United States
Harvard Medical School Department of Genetics, United States
2015/12/01 - 2019/12/11 Researcher (Research) Universidade de Coimbra, Portugal
2013/09 - 2014/06 Researcher (Research) Universidade de Coimbra, Portugal
2012/01 - 2012/06 Research Trainee (Research) Universidade de Trás-os-Montes e Alto Douro, Portugal
Outputs

Publications

Book chapter
  1. Schultz, Michael B.; Rinaldi, Conrad; Lu, Yuancheng; Amorim, João A.; Sinclair, David A.. "Molecular and Cellular Characterization of SIRT1 Allosteric Activators". In Basiswissen Psychologie, 133-149. Springer Berlin Heidelberg, 2019.
    Published • 10.1007/978-1-4939-9434-2_8
  2. Amorim, Joao Alves; Teodoro, Joao Soeiro; Palmeira, Carlos Marques; Rolo, Anabela Pinto. "Sirtuins and Bile Acids: Potential Anti-obesity Strategies Targeting Mitochondria". In Anti-Obesity Drug Discovery and Development: Volume 4, 57-97. BENTHAM SCIENCE PUBLISHERS, 2018.
    10.2174/9781681085586118040005
Conference poster
  1. Amorim, João; Thakur, Sachin; Bonkowski, Michael S; Rolo, Anabela P.; Palmeira, Carlos M.; Sinclair, David A.. "An activation-defective mouse mutant as a model to unravel the mechanisms of SIRT1 activators". Paper presented in Mechanisms of Aging | CSHL - Cold Spring Harbor Laboratory, 2018.
  2. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A.; Palmeira, Carlos M.. "Modification of mitochondria in glutamatergic nerve terminals in early Alzheimer's disease". Paper presented in Mitochondrial DNA and neurodegeneration, 2015.
  3. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A; Palmeira, Carlos M.. "Altered mitochondria membrane potential in glutamatergic terminals associated with synaptic loss in an in vitro animal model of early Alzheimer's disease". Paper presented in 25th Biennial Meeting of the International Society for Neurochemistry, 2015.
  4. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A.; Palmeira, Carlos M.. "Predominant susceptibility of mitochondrial membrane potential from glutamatergic nerve terminals in an in vitro model of early Alzheimer’s disease". Paper presented in XIV Meeting of the Portuguese Society for Neurosciences, 2015.
  5. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A.; Palmeira, Carlos M.. "Glutamatergic nerve terminals display altered mitochondria in an animal model of early Alzheimer's disease". Paper presented in Portuguese Society of Biochemistry, 2014.
  6. Amorim, João; Canas, Paula M.; Duarte, Filipe V.; Tomé, Angelo R.; Rolo, Anabela P.; Cunha, Rodrigo A.; Palmeira, Carlos M.. "Mitochondria in glutamatergic nerve terminals are selectively affected by exposure to Aß1-42 modeling early Alzheimer's disease". Paper presented in MITOBRAIN: Mitochondrial Functions and Dysfunctions in the CNS, 2014.
Journal article
  1. Palmeira, Carlos Marques; Teodoro, João Soeiro; Amorim, João Alves; Steegborn, Clemens; Sinclair, David A.; Rolo, Anabela Pinto. "Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins". Free Radical Biology and Medicine 141 (2019): 483-491. http://dx.doi.org/10.1016/j.freeradbiomed.2019.07.017.
    10.1016/j.freeradbiomed.2019.07.017
  2. Amorim, João; Thakur, Sachin; Bonkowski, Michael S; Rolo, Anabela P.; Palmeira, Carlos M.; Sinclair, David A.. "A NEW MOUSE MODEL TO UNRAVEL THE MECHANISM OF SIRT1 ACTIVATION". Innovation in Aging 2 (Suppl 1) (2018): 878-878. https://academic.oup.com/innovateage/article/2/suppl_1/878/5183703.
  3. Ross, J M; Coppotelli, G; Amorim, J; Hillstedt, E; Potts, E; Sinclair, D. "DISRUPTING THE EPIGENOME IN NOVEL NICE MICE TO STUDY AGE-RELATED COGNITIVE DECLINE". Innovation in Aging 2 suppl_1 (2018): 626-626. http://dx.doi.org/10.1093/geroni/igy023.2333.
    10.1093/geroni/igy023.2333
  4. Teodoro, João S.; Amorim, João A.; Silva, Rui; Rolo, Anabela P.; Steegborn, Clemens; Sinclair, David A.; Palmeira, Carlos M.. "Sirtuin- cAMP crosstalk in metabolic diseases: nucleus versus mitochondria". Free Radical Biology and Medicine 120 (2018): S160. http://dx.doi.org/10.1016/j.freeradbiomed.2018.04.526.
    10.1016/j.freeradbiomed.2018.04.526
  5. Amorim, João A.; Canas, Paula M.; Tomé, Angelo R.; Rolo, Anabela P.; Agostinho, Paula; Palmeira, Carlos M.; Cunha, Rodrigo A.. "Mitochondria in Excitatory and Inhibitory Synapses have Similar Susceptibility to Amyloid-ß Peptides Modeling Alzheimer’s Disease". Journal of Alzheimer's Disease 60 2 (2017): 525-536. http://dx.doi.org/10.3233/jad-170356.
    10.3233/jad-170356
  6. Duarte, Filipe V.; Amorim, João A.; Varela, Ana T.; Teodoro, João S.; Gomes, Ana P.; Cunha, Rodrigo A.; Palmeira, Carlos M.; Rolo, Anabela P.. "Adenosine receptors: regulatory players in the preservation of mitochondrial function induced by ischemic preconditioning of rat liver". Purinergic Signalling 13 2 (2016): 179-190. http://dx.doi.org/10.1007/s11302-016-9548-x.
    10.1007/s11302-016-9548-x
  7. Duarte, Filipe; Amorim, Joao; Palmeira, Carlos; Rolo, Anabela. "Regulation of Mitochondrial Function and its Impact in Metabolic Stress". Current Medicinal Chemistry 22 20 (2015): 2468-2479. http://dx.doi.org/10.2174/0929867322666150514095910.
    10.2174/0929867322666150514095910
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2015 Modification of mitochondria in excitatory synapses in early Alzheimer's disease VIII Encontro de Bioquímica da Universidade de Trás-os-Montes e Alto Douro
Nebioq - Nucleo de Estudante de Bioquímica (Vila Real, Portugal)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/09/08 - 2016/09/08 The 12th Edition of the Doctoral Programme of Experimental Biology and Biomedicine (PDBEB) of the Center for Neurosciences and Cell Biology – University of Coimbra, proudly presented the Third Edition of the BEB Symposium, which took place on September 8 at the Museu da Ciência de Coimbra (The Science Museum that is part of the University of Coimbra UNESCO Heritage Site). More information at: http://www.uc.pt/en/iii/bebsymposium (2016/09/08 - 2016/09/08)
Congress (Co-organisor)
 The 12th Edition of the Doctoral Programme of Experimental Biology and Biomedicine (PDBEB) of the Center for Neuroscience and Cell Biology (CNC) — University of Coimbra, Portugal
Distinctions

Award

2015 Travel Grant - Mitochondrial DNA and Neurodegenration EMBO Workshop
European Molecular Biology Organization, Germany
2015 Full PhD Fellowship
Fundação para a Ciência e a Tecnologia, Portugal
2014 Travel Award - MITOBRAIN: Mitochondrial Functions and Dysfunctions in the CNS
International Bordeaux Neurocampus, France