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Ivo E. Sampaio-Dias (https://orcid.org/0000-0002-9071-6197) is an Invited Assistant Professor at the Department of Chemistry and Biochemistry of the Faculty of Sciences of the University of Porto (FCUP) and an Integrated Ph.D. researcher at REQUIMTE (since 2021) in the framework of the 3rd Individual CEEC - Scientific Employment Stimulus by FCT (DOI: 10.54499/2020.02311.CEECIND/CP1596/CT0004) performing independent research as a Project Leader in ORCHIDS@REQUIMTE (https://www.fc.up.pt/orchids/projlead.html) on Melanostatin (MIF-1) neuropeptide as a strategy to tackle Parkinson's disease (PD). Ivo Dias received his Ph.D. in Sustainable Chemistry (October 2018) from Porto, Aveiro, and Nova de Lisboa Universities after completing his M.Sc. (2013) and B.Sc. (2011) in Biochemistry. His multidisciplinary training includes certification as an independent researcher in tissues and cell culture by the Portuguese Institute of Oncology (2017). During 2018-2020, IESD integrated an FCT-funded research project (ref: PTDC/BIA-MIB/29059/2017) entitled "SilaSeco: Synthesis and Biological Evaluation of Sila-Secosteroids" as a post-doc researcher, combining docking, organic synthesis, and biological evaluation of vitamin D derivatives with antineoplastic activity, being co-inventor of a PCT patent (ref. PCT/IB2022/052839) "Sila-Analogues of Vitamin D Compounds, Method of Producing Said Compounds and Uses Thereof". In 2024, IESD secured a competitive research grant funded by the FCT entitled "Melanostatin Peptide-Peptoid Hybrids: A Tailored Pharmacological Strategy to Tackle Parkinson’s Disease", being currently the PI of another FCT-funded project "DynaPro: Probing Dynamic Chirality to the Rescue of Melanostatin in Parkinson's Therapy" (DOI: 10.54499/2022.01175.PTDC), with the establishment of relevant partnerships at both national (Laboratory of Toxicology, Faculty of Pharmacy, University of Porto) and international institutions (Center for Research in Biological Chemistry and Molecular Materials and BioFarma research group at USC, and IKERBASQUE at the University of the Basque Country), to carry pharmacological, biological, and computational experiments. Since 2013, IESD has published 23 research papers in journals of high impact factors, 14 of which as the corresponding author, including Green Chemistry, Journal of Medicinal Chemistry, ACS Chemical Neuroscience, and Organic Chemistry Frontiers. Furthermore, IESD has participated in several national and international scientific events presenting 30 oral communications (including an invited keynote) and 57 posters, 6 of them distinguished (4 in the field of MIF-1 research). IESD received the IACOBUS Research Papers Award (2024) and the IACOBUS Patents Award (2022), which reward research excellence in transborder cooperation between Galicia and North Portugal. IESD has supervised a total of 55 students: 4 Ph.D. (Sustainable Chemistry), 8 M.Sc. (Biochemistry/Pharmaceutical Chemistry), 15 B.Sc. (Chemistry/Biochemistry), and 28 undergraduate students. IESD has also participated as a member of academic degrees of 21 students (including 3 Ph.D. and 9 M.Sc.). Previous teaching activities include positions as an Assistant (2017-2019) and Adjunct Professor (2019-2020) at the Health School of the Institute Polytechnic of Porto and as a tutor of the Synthesis of Pharmaceuticals course included in the Master's degrees in Chemistry (Q4024) and Biochemistry (Q4114) at FCUP (2021-2023). In 2018, IESD was awarded a grant from the European Peptide Society to attend the 35th European Peptide Symposium (35EPS) in Dublin, Ireland. In 2023, IESD was appointed Associate Editorial Board Member of Current Medicinal Chemistry (Bentham Science). Main research topics: i) development of new methodologies in peptide chemistry; ii) synthesis and pharmacological characterization of allosteric modulators targeting GPCRs with applications in Medicinal Chemistry.
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Identification

Personal identification

Full name
Ivo Emanuel Sampaio Dias
Date of birth
1989/02/13
Gender
Male

Citation names

  • Ivo E. Sampaio-Dias

Author identifiers

Ciência ID
E41A-83AF-9308
ORCID iD
0000-0002-9071-6197
Researcher Id
L-1651-2016
Scopus Author Id
55846135300

Email addresses

  • ivdias@fc.up.pt (Professional)

Addresses

  • Dept. of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, Rua do Campo Alegre s/n, Porto, Portugal, 4169-007, Massarelos, Porto, Portugal (Professional)

Websites

Knowledge fields

  • Exact Sciences - Chemical Sciences
  • Medical and Health Sciences - Basic Medicine

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2014/02/22 - 2018/10/10
Concluded
 Sustainable Chemistry (Doutoramento)
Major in Organic and Medicinal Chemistry
Universidade do Porto Faculdade de Ciências, Portugal

Universidade de Aveiro Departamento de Química, Portugal

Universidade Nova de Lisboa Departamento de Química, Portugal
"Enantioselective Synthesis and Biological Evaluation of PLG and GPE Peptidomimetics" (THESIS/DISSERTATION)
 Approved
2017/09/04 - 2017/09/08
Concluded
 Basic Course of Cell Culture (Diploma de especialização)
Major in Biology
Instituto Português de Oncologia do Porto Francisco Gentil Centro de Investigação, Portugal
 Approved
2011/09 - 2013/11
Concluded
 Biochemistry (Mestrado)
Major in Organic and Medicinal Chemistry
Universidade do Porto Faculdade de Ciências, Portugal

Universidade de Santiago de Compostela Facultad de Farmacia, Spain
"Síntese de Prolinomiméticos do PLG com Potencial Atividade Neuroprotetora" (THESIS/DISSERTATION)
 18 out of 20
2011/02 - 2012/07
Concluded
 Extracurricular Internship in Organic Synthesis (Outros)
Universidade do Porto Faculdade de Ciências, Portugal
 5 out of 5
2008/09 - 2011/09
Concluded
 Biochemistry (Licenciatura)
Major in Organic and Medicinal Chemistry
Universidade do Porto, Portugal
"Síntese de Novos Tripéptidos Prolinomiméticos com Potencial Actividade Neuroprotectora" (THESIS/DISSERTATION)
 16 out of 20
2008 - 2009
Concluded
 Extracurricular Course: Introduction to Legal Medicine (Outros)
Major in Medicina Legal (Legal Medicine)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
 Approved
Affiliation

Science

Category
Host institution 		Employer
2021/01/01 - Current Contracted Researcher (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2022/09/01 - 2022/11/30 Visiting Researcher (Research) Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Spain
REQUIMTE LAQV Porto, Portugal
2018/11/01 - 2021/03/31 Researcher (Research) REQUIMTE LAQV Porto, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2018 - 2019 Postdoc (Research) REQUIMTE, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2009/09 - 2011/02 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008 - 2011 Researcher (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2024/02/01 - Current Invited Assistant Professor (University Teacher) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2021/09 - 2023/12 Tutor (University Teacher) Universidade do Porto Faculdade de Ciências, Portugal
Universidade do Porto Faculdade de Ciências, Portugal
2019/09/16 - 2020/09 Invited Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2017/09 - 2019/09 Invited Assistant (Polytechnic Teacher) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Others

Category
Host institution 		Employer
2014/01 - 2018/01 PhD Student Fundação para a Ciência e a Tecnologia, Portugal
REQUIMTE, Portugal
Projects

Grant

Designation Funders
2014/01 - 2018/10/10 Enantioselective Synthesis and Biological Evaluation of PLG and GPE Proline Mimetics (SFRH/BD/93632/2013)
SFRH/BD/93632/2013
PhD Student Fellow
Fundação para a Ciência e a Tecnologia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2009 - 2011 Study of the Role of Class III Peroxidases from Arabidopsis thaliana by Reverse and Functional Genetics (C2008 LA280125 BII 2)
C2008 LA280125 BII 2
Research Fellow
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2025/01/01 - Current Pep2mer: Melanostatin Peptide-Peptoid Hybrids - A Tailored Pharmacological Strategy to Tackle Parkinson’s Disease (2023.14440.PEX)
2023.14440.PEX
Principal investigator
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2024/10/01 - Current PepTRAP - An Innovative Pharmacological Approach to Tackle Parkinson's Disease
BIP Proof - 70
Principal investigator
REQUIMTE LAQV Porto, Portugal
 Universidade do Porto
Ongoing
2021/04/01 - 2027/03/31 SilaPro: A Bioisosteric Strategy to Rescue MIF-1 Neuropeptide by the Development of Orally-Available Sila-Derivatives for Application in Parkinson's Disease (2020.02311.CEECIND/CP1596/CT0004)
2020.02311.CEECIND/CP1596/CT0004
10.54499/2020.02311.CEECIND/CP1596/CT0004
Principal investigator
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Laboratório Associado para a Química Verde - Tecnologias e Processos Limpos (LA/P/0008/2020)
LA/P/0008/2020
10.54499/LA/P/0008/2020
Researcher
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Aveiro, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade de Évora, Portugal

Unidade de Investigação Vidro e Cerâmica para as Artes, Portugal

Universidade de Lisboa Instituto Dom Luiz, Portugal

Universidade NOVA de Lisboa, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2023/01/01 - 2024/12/31 DynaPro: Probing Dynamic Chirality to the Rescue of Melanostatin in Parkinson's Therapy (2022.01175.PTDC)
2022.01175.PTDC
10.54499/2022.01175.PTDC
Principal investigator
Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Universidade de Santiago de Compostela Facultade de Farmacia, Spain

Universidad del País Vasco, Spain
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2021/03 SilaSeco - Synthesis and Biological Evaluation of Sila-Secosteroids (REQUIMTE 2019-85)
PTDC/BIA-MIB/29059/2017
Research Fellow
REQUIMTE LAQV Porto, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/11/01 - 2019/11/30 SilaSeco - Synthesis and Biological Evaluation of Sila-Secosteroids (REQUIMTE 2018-16)
PTDC/BIA-MIB/29059/2017
Post-doc Fellow
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. Maronde, DAIANE; Ivo E. Sampaio-Dias; Luís Pinto da Silva; Lourenço, Leandro; J. E. Rodriguez-Borges. "Coelenterazine Derivatives as Potential Drugs for Photodynamic Therapy". Paper presented in 8th International Electronic Conference on Medicinal Chemistry, 2022.
    10.3390/ecmc2022-13447
Conference poster
  1. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Correia, Xavier Cruz; Hugo F. Costa-Almeida; García-Mera, Xerardo; José Brea; María Isabel Loza; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Bioisosteric Replacement of Proline by Heteroaromatic Scaffolds in Melanostatin Neuropeptide". Paper presented in X SEQT Symposium of Medicinal Chemistry Young Researchers, 2024.
  2. Sara C. Silva-Reis; Daniela Correia da Silva; David M. Pereira; Correia, Xavier Cruz; Hugo F. Costa-Almeida; Beatriz L. Pires-Lima; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Neuropeptide Conjugates as Aß25-35-Induced Protein Aggregation Inhibitors". Paper presented in X SEQT Symposium of Medicinal Chemistry Young Researchers, 2024.
  3. Hugo F. Costa-Almeida; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Correia, Xavier Cruz; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Rescuing Melanostatin Neuropeptide for Application in Neurodegenerative Diseases". Paper presented in X SEQT Symposium of Medicinal Chemistry Young Researchers, 2024.
  4. Correia, Xavier Cruz; Sara C. Silva-Reis; Hugo F. Costa-Almeida; Beatriz L. Pires-Lima; Miguel Santejo; Márcia A. Liz; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Assembly of Bioactive Glypromate Derivatives using 2-Azanorbornane as a Proline Isostere". Paper presented in X SEQT Symposium of Medicinal Chemistry Young Researchers, 2024.
  5. Costa-Almeida, Hugo F.; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Correia, Xavier Cruz; Maronde, DAIANE; Vera M. Costa; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Lipophilic Bullet Strategy to Rescue Melanostatin Neuropeptide for Application in Neurodegenerative Diseases". Paper presented in Ciência 2024, 2024.
  6. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Hugo F. Costa-Almeida; Correia, Xavier Cruz; Daniela Correia da Silva; David M. Pereira; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Unveiling Neuroprotective Conjugates against Aß25-35-Induced In Vitro Protein Aggregation". Paper presented in Ciência 2024, 2024.
  7. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Brea; María Isabel Loza; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Heteroaromatic-Based Melanostatin Isosteres for Application in Parkinson's Disease". Paper presented in Ciência 2024, 2024.
  8. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Synthesis and structural analysis of cyclic aza-amino acid derivatives for the assembly of azapeptides". Paper presented in 15º Encontro Nacional de Química Orgânica (ENQO) / 8º Encontro Nacional de Química Terapêutica (ENQT), 2024.
  9. Ivo E. Sampaio-Dias; Maronde, DAIANE; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Costa, Vera M; García-Mera, Xerardo; J. E. Rodriguez-Borges. Corresponding author: Ivo E. Sampaio-Dias. "Exploring the Lipophilic Bullet Approach in Melanostatin Neuropeptide". Paper presented in IX SEQT Symposium of Medicinal Chemistry Young Researchers, 2023.
  10. Joana P. Oliveira; Henrique R. Rodrigues; Correia, Xavier Cruz; Sara C. Silva-Reis; Costa-Almeida, Hugo F.; Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Application of Aza-Proline-Based Scaffolds for the Assembly of Glypromate Analogues". Paper presented in 16th Meeting of Young Researchers of University of Porto (IJUP'23), 2023.
  11. Henrique R. Rodrigues; Joana P. Oliveira; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Sara C. Silva-Reis; Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Exploring the Synthesis of Activated Aza-Proline and Aza-Pipecolic Acid and Their Structural Analysis by X-ray Crystallography". Paper presented in 16th Meeting of Young Researchers of University of Porto (IJUP'23), 2023.
  12. Mariana Silva; Tiago Pinheiro; Inês Ferreira; Ivo E. Sampaio-Dias; Maronde, DAIANE; Luís Pinto da Silva; J. E. Rodriguez-Borges. Corresponding author: Maronde, DAIANE. "Exploring the assembly of aminopyrazine acrylamides for application in cancer treatment: optimization of the reactional conditions". Paper presented in 16th Meeting of Young Researchers of University of Porto (IJUP'23), 2023.
  13. Inês Ferreira; Mariana Silva; Tiago Pinheiro; Ivo E. Sampaio-Dias; Maronde, DAIANE; Luís Pinto da Silva; J. E. Rodriguez-Borges. Corresponding author: Maronde, DAIANE. "Synthesis of aminopyrazine-based acrylamides as precursors of new photosensitizers for application in cancer treatment". Paper presented in 16th Meeting of Young Researchers of University of Porto (IJUP'23), 2023.
  14. Tiago Pinheiro; Mariana Silva; Inês Ferreira; Ivo E. Sampaio-Dias; Maronde, DAIANE; Luís Pinto da Silva; J. E. Rodriguez-Borges. Corresponding author: Maronde, DAIANE. "Synthesis of aminopyrazine derivatives with potential application in cancer treatment". Paper presented in 16th Meeting of Young Researchers of University of Porto (IJUP'23), 2023.
  15. Correia, Xavier Cruz; Sara C. Silva-Reis; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Ivo E. Sampaio-Dias. "On-Site N-Hydroxylation of Proline-Containing Peptides". Paper presented in ENEQUI - Encontro Nacional de Estudantes de Química, 2023.
  16. Beatriz L. Pires-Lima; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Costa, Vera M; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. "Using Proline Bioisosteres for the Assembly of Potent Melanostatin (MIF-1) Analogues". Paper presented in ENEQUI - Encontro Nacional de Estudantes de Química, 2023.
  17. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; da Silva, Daniela Correia; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; Costa, Vera Marisa; et al. "Discovery of Glypromate Conjugates with Biomedical Applications in Alzheimer's Disease". Paper presented in 2nd Symposium on Alzheimer's Disease, 2023.
  18. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Miguel Santejo; Liz, Márcia Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Ivo E. Sampaio-Dias. "Discovery of Neuroprotective Hits Using 2-Azanorbornane as a Constrained Proline Surrogate in Glypromate Neuropeptide". Paper presented in Congreso Internacional: XXVI Encontro Galego-Portugués de Química, 2022.
  19. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Sara C. Silva-Reis. "Design, Synthesis, and Biological Evaluation of Glypromate-Based Neuroprotective Conjugates with Pharmaceutical Active Ingredients". Paper presented in Congreso Internacional: XXVI Encontro Galego-Portugués de Química, 2022.
  20. Maronde, DAIANE; Ivo E. Sampaio-Dias; Luís Pinto da Silva; Leandro M. O. Lourenço; José Enrique Rodriguez Borges. "Study of New Derivatives Based on Coelenterazine for Photodynamic Therapy". Paper presented in Congreso Internacional: XXVI Encontro Galego-Portugués de Química, 2022.
  21. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Hugo F. Costa-Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Peptide-amine Conjugates targeting Neurodegenerative Diseases". Paper presented in XX National Meeting of the Spanish Society of Medicinal Chemistry (SEQT), 2022.
  22. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Application of Hybrid Glypromate® Conjugates in Neurodegenerative Diseases". Paper presented in Encontro Ciência 2022, 2022.
  23. Renata Santana; Ivo E. Sampaio-Dias; Luciano Eduardo Rodrigues dos Santos; Sara C. Silva-Reis; García-Mera, Xerardo; José Enrique Rodriguez Borges. "A New Methodology for the Synthesis of N-functionalized Glycines: Assembly of Melanostatin-Based Peptoids". Paper presented in 15th Meeting of Young Researchers of University of Porto (IJUP'22), 2022.
  24. Luciano Eduardo Rodrigues dos Santos; Ivo E. Sampaio-Dias; Renata Santana; Sara C. Silva-Reis; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Macrocyclization of Melanostatin Neuropeptide by Ring-Closing Metathesis". Paper presented in 15th Meeting of Young Researchers of University of Porto (IJUP'22), 2022.
  25. Hugo F. Costa-Almeida; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Xavier Cruz Correia; García-Mera, Xerardo; José Enrique Rodriguez Borges; Ivo E. Sampaio-Dias. "Synthesis and Pharmacological Evaluation of Melanostatin Analogues Containing Chiral ß-Amino Acids as Proline Surrogates". Paper presented in 7th International Electronic Conference on Medicinal Chemistry, 2021.
  26. Xavier Cruz Correia; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Hugo F. Costa-Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Using aza-Proline for the Assembly of a Melanostatin aza-Peptide Derivative". Paper presented in 7th International Electronic Conference on Medicinal Chemistry, 2021.
  27. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Beatriz L. Pires-Lima; Xavier Cruz Correia; Hugo F. Costa-Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. "The Design of New Trofinetide® Conjugates Using Constrained Prolines". Paper presented in XXVII Encontro Nacional da Sociedade Portuguesa de Química, 2021.
  28. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Miguel Santejo; Liz, Márcia Almeida; Cristina Alcoholado; Algarra, Manuel; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Probing Constrained Prolines for the Assembly of Neuroprotective Glypromate® Peptidomimetics". Paper presented in RICT – 56th International Conference on Medicinal Chemistry (Interfacing Chemical Biology and Drug Discovery), 2021.
  29. Hugo F. Costa-Almeida; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Xavier Cruz Correia; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Assembly of Melanostatin Peptidomimetics Using Chiral ß-Amino Acids as Proline Surrogates". Paper presented in XIV Meeting of Young Researchers of the University of Porto (IJUP), 2021.
  30. Beatriz L. Pires-Lima; Xavier Cruz Correia; Hugo F. Costa-Almeida; Sara C. Silva-Reis; García-Mera, Xerardo; José Enrique Rodriguez Borges; Ivo E. Sampaio-Dias. "Replacement of Proline Residue in Melanostatin Neuropeptide by Chiral and Achiral Scaffolds: a Bioisosteric Approach". Paper presented in VI Jornadas da Bioquímica, 2021.
  31. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Beatriz L. Pires-Lima; Xavier Cruz Correia; Hugo F. Costa-Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. "NeuroPro: An Innovative Approach for the Assembly of New Neuroprotective Conjugates.". Paper presented in Digital Colloquium, 2021.
  32. Xavier Cruz Correia; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Hugo F. Costa-Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Exploring the Assembly of Melanostatin (MIF-1) Aza-Peptidomimetics". Paper presented in Digital Colloquium, 2021.
  33. Beatriz L. Pires-Lima; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Xavier Cruz Correia; Hugo F. Costa-Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Exploring the role of Proline's Secondary Amine on Melanostatin (MIF-1) Neuropeptide using a Bioisosteric Approach". Paper presented in Digital Colloquium, 2021.
  34. Hugo F. Costa-Almeida; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Beatriz L. Pires-Lima; Xavier Cruz Correia; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Exploring the Synthesis and Pharmacological Evaluation of Melanostatin (MIF-1) Peptidomimetics Bearing Chiral ß-Amino Acids as Proline Surrogates". Paper presented in Digital Colloquium, 2021.
  35. Ivo E. Sampaio-Dias; José Enrique Rodriguez Borges; José Brea; Dolores Viña; Mabel Losa; Olga Caamaño; Humbert González-Díaz; García-Mera, Xerardo. "PTML Computational Study, Synthesis, and Pharmacological Assay of MIF-1 Peptidomimetics". Paper presented in MOL2NET 2020, International Conference on Multidisciplinary Sciences, 6th edition, 2021.
  36. Beatriz L. Pires-Lima; Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Correia, Xavier Cruz; Hugo F. Costa-Almeida; García-Mera, Xerardo; José Enrique Rodriguez Borges. "Exploring the Bioisosterism of Proline Residue in Melanostatin Neuropeptide Using Heteroaromatic Scaffolds". Paper presented in 7th International Electronic Conference on Medicinal Chemistry, 2021.
  37. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Xerardo García-Mera; José E. Rodríguez-Borges. "Rescuing of neuroprotective peptides by chemical conjugation with lipophilic active pharmaceutical ingredients". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
  38. Beatriz Lopes P. Lima; Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Xerardo García-Mera; José E. Rodríguez-Borges. "Synthesis, pharmacological, and biological evaluation of pyridine-based MIF-1 peptidomimetics as positive allosteric modulators of D2R". Paper presented in 6th International Electronic Conference on Medicinal Chemistry, 2020.
  39. Ivo E. Sampaio-Dias; António Xavier V. C. Cruz-Correia. "Synthesis of Novel Amprenavir Analogues Based on 2-Furoyl Scaffolds". Paper presented in Encontro Investigação Jovem da Universidade do Porto, 2020.
  40. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; García-Mera, Xerardo; José E. Rodríguez-Borges. "Synthesis, Pharmacological and Biological Evaluation of PLG Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2 Receptors". Paper presented in XXVI Encontro Nacional da Sociedade Portuguesa de Química, 2019.
  41. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Liz, Márcia Almeida; José Enrique Rodríguez Borges. "Development of New GPE Conjugates with Potentially Synergistic Properties (Desenvolvimento de Novos Conjugados do GPE com Propriedades Potencialmente Sinérgicas)". Paper presented in XXIV Encontro Luso-Galego de Química, 2018.
  42. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; José E. Rodríguez-Borges. "Preparation of enantiomerically pure forms of 2-azanorbornane-3-exo-carboxylic acid through asymmetric aza-Diels-Alder reactions (Preparação das formas enantiomericamente puras do ácido 2-azanorbornano-3-exo-carboxílico através de reacções de aza-Diels-Alder assimétricas)". Paper presented in XXIV Encontro Luso-Galego de Química, 2018.
  43. Ivo E. Sampaio-Dias; Silva-Reis, Sara C.; X. Garcia-Mera; J. E. Rodriguez-Borges. "One-Pot Assembly of Oligopeptides in Solution-Phase". Paper presented in 35th European Peptide Symposium (35EPS) Dublin, 2018.
  44. Ivo E. Sampaio-Dias; Silva-Reis, Sara C.; X. Garcia-Mera; J. E. Rodriguez-Borges. "Development of a Highly Efficient One-pot Protocol for the Synthesis of Oligopeptides in Solution-Phase". Paper presented in 16th Iberian Peptide Meeting (16EPI) / 4th Chemical Biology Group Meeting (4GEQB) Barcelona, 2018.
  45. Ivo E. Sampaio-Dias; Silva-Reis, Sara C.; X. Garcia-Mera; J. E. Rodriguez-Borges. "Greener Approach for the Synthesis of Oligopeptides in Solution-Phase". Paper presented in 12º Encontro Nacional de Química Orgânica (ENQO) / 5º Encontro Nacional de Química Terapêutica (ENQT), 2018.
  46. Silva-Reis, Sara C.; Ivo E. Sampaio-Dias; Jéssica Eira; Márcia Liz; J. E. Rodriguez-Borges. "Exploring the Potential Synergic Effect of GPE Lipophilic Conjugates with Neuroprotective Amines". Paper presented in 12º Encontro Nacional de Química Orgânica (ENQO) / 5º Encontro Nacional de Química Terapêutica (ENQT), 2018.
  47. Silva-Reis, Sara C.; Ivo E. Sampaio-Dias; J. E. Rodriguez-Borges. "Synthesis of Lipophilic Glycyl-L-Prolyl-L-Glutamic acid (GPE) derivatives as Potential Neuroprotective Therapeutic Agents". Paper presented in 10th Meeting of Young Researchers of University of Porto (IJUP'17), 2017.
  48. Ivo E. Sampaio-Dias; Sara Ribeiro; X. Garcia-Mera; J. E. Rodriguez-Borges. "Synthesis and Pharmacological Evaluation of PLG Peptidomimetics (Síntese e Avaliação Farmacológica de Peptidomiméticos do PLG)". Paper presented in XXII Encontro Luso-Galego de Química: XXII ELGQ, 2016.
  49. Ivo E. Sampaio-Dias; Sara Ribeiro; X. Garcia-Mera; J. E. Rodriguez-Borges. "Design, Synthesis and Evaluation of PLG Peptidomometics based on 2-azanorbornane scaffold". Paper presented in Terceiro Simpósio Iberoamericano de Química Orgânica, 2016.
  50. Ivo E. Sampaio-Dias; Sara Ribeiro; X. Garcia-Mera; J. E. Rodriguez-Borges. "Synthesis and Allosteric Modulation of the Dopamine Receptor by 2-azanorbornane-based peptidomimetics of L-prolyl-L-leucylglycinamide (PLG)". Paper presented in Encontro Ciência 2016, 2016.
  51. Sara Ribeiro; Ivo E. Sampaio-Dias; X. Garcia-Mera; J. E. Rodriguez-Borges. "Lipophilic-Derived Peptidomimetics of Neuropeptide GPE with 2-azanorbornane system as Proline Scaffold". Paper presented in 9th Meeting of Young Researchers of University of Porto (IJUP'16), 2016.
  52. Ivo E. Sampaio-Dias; X. Garcia-Mera; J. E. Rodriguez-Borges; Dinarte Neves. "Synthesis of PLG Analogues with Potencial Neuroprotective Activity based on Picolinic Acid Scaffold". Paper presented in III AEICBAS Biomedical Congress, 2015.
  53. Ivo E. Sampaio-Dias; Dinarte Neves; X. Garcia-Mera; J. E. Rodriguez-Borges. "Exploring the Synthesis of PLG Peptidomimetics with Potential Neuroprotective Activity Based on Picolinic Acid Scaffold". Paper presented in 8th Meeting of Young Researchers of University of Porto (IJUP'15), 2015.
  54. I. E. Sampaio-Dias; D. Neves; Fabiana Barros-Santos; X. Garcia-Mera; J. E. Rodriguez-Borges. "Synthesis of Neuroprotective Prolinomimetic Tripeptides PLG Analogs (Síntese de Tripéptidos Prolinomiméticos Neuroprotectores Análogos do PLG)". Paper presented in XX Encontro Luso-Galego de Química, 2014.
  55. Ivo E. Sampaio-Dias; Dinarte Neves; José Enrique Rodríguez Borges; García-Mera, Xerardo. "Enantiosselective Synthesis and Biological Evaluation of Proline mimetic of PLG Based on (1R,3S)-2-azabicyclo[2.2.1]heptane". Paper presented in IJUP 2014, 2014.
  56. Dias, Ivo Emanuel Sampaio; José Enrique Rodríguez Borges; Xerardo García Mera. "Synthesis of new Prolimimetics of PLG with Potencial Neuroprotective Activity". Paper presented in IJUP 2013, 2013.
  57. Ivo E. Sampaio-Dias; José Enrique Rodriguez Borges; García-Mera, Xerardo. "New Synthetic Approach to Prolinemimetics of PLG Derived From 2-Azabicyclo[2.2.1]heptane System". Paper presented in 10º Encontro Nacional de Química Orgânica, 2013.
  58. Ivo E. Sampaio-Dias; J. E. Rodriguez-Borges; García-Mera, Xerardo. "Synthesis of New Prolinemimetics Based on 2-azabicyclo[2.2.1]heptane System". Paper presented in 10º Encontro Nacional de Química Orgância, 1º Simpósio Luso-Brasileiro de Química Orgânica, 2013.
  59. Ivo E. Sampaio-Dias; J. E. Rodriguez-Borges; García-Mera, Xerardo. Corresponding author: Ivo E. Sampaio-Dias. "Synthesis of New Proline-Mimetics of PLG with Potencial Neuroprotective Activity". Paper presented in 6th Meeting of Young Researchers of U. Porto, 2013.
  60. Dias, Ivo Emanuel Sampaio; Ana Silva Guimarães; Raquel Figueiredo; Mariana Sottomayor. "Overexpression of target class III peroxidases in Arabidopsis thaliana". Paper presented in IJUP 2011, 2011.
  61. Dias, Ivo Emanuel Sampaio; Fábio Rizzo Aguiar; José Enrique Rodríguez Borges. "Synthesis of New Proline-Mimetics Tripeptides with Neuroprotective Activity". Paper presented in IJUP, 2011.
  62. Ivo E. Sampaio-Dias; J. E. Rodriguez-Borges; Fábio Rizzo Aguiar. "Synthesis of New Proline-Mimetics Tripeptides with Neuroprotective Activity". Paper presented in 4th Meeting of Young Researchers of U. Porto, 2011.
  63. Ivo E. Sampaio-Dias; Raquel Figueiredo; Ana Silva Guimarães; Sottomayor, Mariana. "Overexpression of target class III peroxidases in Arabidopsis thaliana". Paper presented in 4th Meeting of Young Researchers of U. Porto, 2011.
  64. Ana Silva Guimarães; Dias, Ivo Emanuel Sampaio; Raquel Figueiredo; Mariana Sottomayor. "Overexpression of target class III peroxidases in Arabidopsis thaliana". Paper presented in Ciência 2010, 2010.
  65. Ivo E. Sampaio-Dias; Raquel Figueiredo; Ana Silva Guimarães; Sottomayor, Mariana. "Overexpression of target class III peroxidases in Arabidopsis thaliana". Paper presented in Ciência 2010, 2010.
Journal article
  1. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; Beatriz L. Pires-Lima; García-Mera, Xerardo. Corresponding author: Ivo E. Sampaio-Dias. "Telescoped One-Pot Strategy for the Assembly of cis-4-Hydroxy-L-Prolyl Amides". ACS Sustainable Chemistry & Engineering (2024): http://dx.doi.org/10.1021/acssuschemeng.4c07215.
    Published • 10.1021/acssuschemeng.4c07215
  2. Sara C. Silva-Reis; Costa, Vera M; da Silva, Daniela Correia; Pereira, David; Correia, Xavier Cruz; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Discovery of hybrid Glypromate conjugates with neuroprotective activity against paraquat-induced toxicity". RSC Medicinal Chemistry (2024): http://dx.doi.org/10.1039/d4md00584h.
    Published • 10.1039/d4md00584h
  3. Sara C. Silva-Reis; Costa, Vera M; da Silva, Daniela Correia; Pereira, David; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; J. E. Rodriguez-Borges; Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Exploring structural determinants of neuroprotection bias on novel glypromate conjugates with bioactive amines". European Journal of Medicinal Chemistry (2024): 116174. http://dx.doi.org/10.1016/j.ejmech.2024.116174.
    Published • 10.1016/j.ejmech.2024.116174
  4. Silva-Reis, Sara C.; Correia, Xavier C.; Costa-Almeida, Hugo F.; Pires-Lima, Beatriz L.; Maronde, Daiane; Costa, Vera M.; García-Mera, Xerardo; et al. Corresponding author: Ivo E. Sampaio-Dias. "Stapling Amantadine to Melanostatin Neuropeptide: Discovery of Potent Positive Allosteric Modulators of the D2 Receptors". ACS Medicinal Chemistry Letters (2023): http://dx.doi.org/10.1021/acsmedchemlett.3c00264.
    Published • 10.1021/acsmedchemlett.3c00264
  5. Sara C. Silva-Reis; Ivo E. Sampaio-Dias; Costa, Vera Marisa; Correia, Xavier Cruz; Costa-Almeida, Hugo F.; García-Mera, Xerardo; J. E. Rodriguez-Borges. "Concise Overview of Glypromate Neuropeptide Research: From Chemistry to Pharmacological Applications in Neurosciences". ACS Chemical Neuroscience (2023): http://dx.doi.org/10.1021/acschemneuro.2c00675.
    Open access • Published • 10.1021/acschemneuro.2c00675
  6. Monteiro, Marta; Ivo E. Sampaio-Dias; Mateus, Nuno; de Freitas, Victor; Cruz, Luís. "Preparation of 10-(hexylcarbamoyl)pyranomalvidin-3-glucoside from 10-carboxypyranomalvidin-3-glucoside using carbodiimide chemistry". Food Chemistry 393 (2022): 133429. http://dx.doi.org/10.1016/j.foodchem.2022.133429.
    Published • 10.1016/j.foodchem.2022.133429
  7. Ivo E. Sampaio-Dias; Carlos A. D. Sousa; Sara C. Silva-Reis; Luís Pinto da Silva; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Ivo E. Sampaio-Dias. "Isolation and Structural Characterization of Stable Carbamic-Carbonic Anhydrides: An Experimental and Computational Study". Organic Chemistry Frontiers (2022): http://dx.doi.org/10.1039/d2qo00038e.
    Published • 10.1039/d2qo00038e
  8. Ivo E. Sampaio-Dias; Silva-Reis, Sara C.; Pires-Lima, Beatriz L.; Correia, Xavier Cruz; Costa-Almeida, Hugo F.. Corresponding author: Ivo E. Sampaio-Dias. "A Convenient On-Site Oxidation Strategy for the N-Hydroxylation of Melanostatin Neuropeptide Using Cope Elimination". Synthesis (2021): http://dx.doi.org/10.1055/a-1695-1095.
    Published • 10.1055/a-1695-1095
  9. Ivo E. Sampaio-Dias; Santejo, Miguel; Silva-Reis, Sara C.; Liz, Márcia A.; Alcoholado, Cristina; Algarra, Manuel; García-Mera, Xerardo; Rodríguez-Borges, José E.. Corresponding author: Ivo E. Sampaio-Dias. "Design, Synthesis, and Biological Evaluation of Hybrid Glypromate Analogues Using 2-Azanorbornane as a Prolyl and Pipecolyl Surrogate". ACS Chemical Neuroscience 12 19 (2021): 3615-3624. http://dx.doi.org/10.1021/acschemneuro.1c00339.
    Published • 10.1021/acschemneuro.1c00339
  10. Ivo E. Sampaio-Dias; Reis-Mendes, Ana; Costa, Vera Marisa; García-Mera, Xerardo; Brea, José; Loza, María Isabel; Pires-Lima, Beatriz L.; et al. Corresponding author: Ivo E. Sampaio-Dias. "Discovery of New Potent Positive Allosteric Modulators of Dopamine D2 Receptors: Insights into the Bioisosteric Replacement of Proline to 3-Furoic Acid in the Melanostatin Neuropeptide". Journal of Medicinal Chemistry 64 9 (2021): 6209-6220. http://dx.doi.org/10.1021/acs.jmedchem.1c00252.
    Published • 10.1021/acs.jmedchem.1c00252
  11. Ivo E. Sampaio-Dias; Rodríguez-Borges, José E.; Yáñez-Pérez, Víctor; Arrasate, Sonia; Llorente, Javier; Brea, José M.; Bediaga, Harbil; et al. Corresponding author: Ivo E. Sampaio-Dias. "Synthesis, Pharmacological, and Biological Evaluation of 2-Furoyl-Based MIF-1 Peptidomimetics and the Development of a General-Purpose Model for Allosteric Modulators (ALLOPTML)". ACS Chemical Neuroscience 12 1 (2020): 203-215. http://dx.doi.org/10.1021/acschemneuro.0c00687.
    Published • 10.1021/acschemneuro.0c00687
  12. Brandão, Pedro; Moreira, Joana; Almeida, Joana; Nazareth, Nair; Ivo E. Sampaio-Dias; Vasconcelos, Vitor; Martins, Rosário; et al. "Norhierridin B, a New Hierridin B-Based Hydroquinone with Improved Antiproliferative Activity". Molecules 25 7 (2020): 1578. http://dx.doi.org/10.3390/molecules25071578.
    Published • 10.3390/molecules25071578
  13. Ivo E. Sampaio-Dias; Luís Pinto da Silva; Silva, Sandra G.; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Ivo E. Sampaio-Dias. "A Sustainable Strategy for the Assembly of Glypromate® and its Structurally-Related Analogues by Tandem Sequential Peptide Coupling". Green Chemistry 22 11 (2020): 3584-3596. http://dx.doi.org/10.1039/d0gc00143k.
    Published • 10.1039/d0gc00143k
  14. Sara C. Silva-Reis; V. D. dos Santos, A. Catarina; García-Mera, Xerardo; José Enrique Rodriguez Borges; Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Bioinspired Design for the Assembly of Glypromate® Neuropeptide Conjugates with Active Pharmaceutical Ingredients". New Journal of Chemistry 44 48 (2020): 21049-21063. http://dx.doi.org/10.1039/d0nj04851h.
    Published • 10.1039/d0nj04851h
  15. Ivo E. Sampaio-Dias; Silva-Reis, Sara C.; García-Mera, Xerardo; Brea, José M.; Loza, Maria Isabel; Alves, Carla; Algarra, Manuel; Rodríguez-Borges, José Enrique. Corresponding author: Ivo E. Sampaio-Dias. "Synthesis, Pharmacological and Biological Evaluation of MIF-1 Picolinoyl Peptidomimetics as Positive Allosteric Modulators of D2R". ACS Chemical Neuroscience (2019): http://dx.doi.org/10.1021/acschemneuro.9b00259.
    Published • 10.1021/acschemneuro.9b00259
  16. Costa, Margarida; Ivo E. Sampaio-Dias; Castelo-Branco, Raquel; Scharfenstein, Hugo; Rezende de Castro, Roberta; Silva, Artur; Schneider, Maria Paula C.; et al. "Structure of Hierridin C, Synthesis of Hierridins B and C, and Evidence for Prevalent Alkylresorcinol Biosynthesis in Picocyanobacteria". Journal of Natural Products 82 2 (2019): 393-402. http://dx.doi.org/10.1021/acs.jnatprod.8b01038.
    Published • 10.1021/acs.jnatprod.8b01038
  17. Ivo E. Sampaio-Dias; Sara C. Silva-Reis; Luís Pinto da Silva; García-Mera, Xerardo; Miguel A. Maestro; José Enrique Rodriguez Borges. Corresponding author: Ivo E. Sampaio-Dias. "Mechanistic Insights for the Transprotection of Tertiary Amines with Boc2O via Charged Carbamates: Access to Both Enantiomers of 2-Azanorbornane-3-exo-carboxylic Acids". Organic Chemistry Frontiers (2019): https://doi.org/10.1039/C9QO00957D.
    Published • 10.1039/C9QO00957D
  18. Ivo E. Sampaio-Dias; Margarida Costa; Raquel Castelo-Branco; Hugo Scharfenstein; Roberta Rezende de Castro; Artur Silva; Maria Paula Cruz Schneider; et al. "Structure, Synthesis of Hierridin C and Discovery of Prevalent Alkylresorcinol Biosynthesis in Picocyanobacteria". ChemRxiv (2018): https://doi.org/10.26434/chemrxiv.7090526.v1.
    Open access • Published
  19. Neves, Patrícia; Nogueira, Lucie S.; Valente, Anabela A.; Pillinger, Martyn; Gonçalves, Isabel S.; Ivo E. Sampaio-Dias; Sousa, Carlos A.D.; Rizzo-Aguiar, Fabio; José Enrique Rodriguez Borges. "Performance of Chiral Tetracarbonylmolybdenum Pyrindanyl Amine Complexes in Catalytic Olefin Epoxidation". Journal of Organometallic Chemistry 858 (2018): 29-36. http://dx.doi.org/10.1016/j.jorganchem.2018.01.003.
    Published • 10.1016/j.jorganchem.2018.01.003
  20. Ivo E. Sampaio-Dias; Sousa, Carlos A. D.; Sara C. Silva-Reis; Ribeiro, Sara; García-Mera, Xerardo; José Enrique Rodriguez Borges. Corresponding author: Ivo E. Sampaio-Dias. "Highly Efficient One-Pot Assembly of Peptides by Double Chemoselective Coupling". Organic & Biomolecular Chemistry 15 36 (2017): 7533-7542. http://dx.doi.org/10.1039/c7ob01544e.
    Published • 10.1039/c7ob01544e
  21. Ivo E. Sampaio-Dias; Sousa, Carlos A. D.; García-Mera, Xerardo; Ferreira da Costa, Joana; Caamaño, Olga; Rodríguez-Borges, José E.. Corresponding author: Ivo E. Sampaio-Dias. "Novel L-prolyl-L-leucylglycinamide (PLG) tripeptidomimetics based on a 2-azanorbornane scaffold as positive allosteric modulators of the D2R". Org. Biomol. Chem. 14 47 (2016): 11065-11069.
    Published • 10.1039/C6OB02248K
  22. Sousa, Carlos A. D.; Ivo E. Sampaio-Dias; García-Mera, Xerardo; Lima, Carlos F. R. A. C.; Rodríguez-Borges, José E.. "On the scope of oxidation of tertiary amines: Meisenheimer rearrangements versus Cope elimination in 2-(cyanoethyl)-2-azanorbornanes". Org. Chem. Front. 3 12 (2016): 1624-1634.
    Published • 10.1039/C6QO00330C
  23. Sousa, Carlos A. D.; Lima, Carlos F. R. A. C.; Ivo E. Sampaio-Dias; Garcia-Mera, Xerardo; Rodríguez-Borges, José E.. "Reactivity and Mechanistic Studies of the Reactions of Chlorodiphenylphosphine and Its Oxide with Methyl Glyoxylate, Glyoxylate Oximes, and Methyl Cyanoformate". Heteroatom Chemistry 26 4 (2015): 249-256.
    Published • 10.1002/hc.21255
  24. Sousa, Carlos A. D.; Ivo E. Sampaio-Dias; Rizzo-Aguiar, Fabio; Garcia-Mera, Xerardo; Rodríguez-Borges, José E.. "Enantiopure synthesis of 7-(1-pyrindanyl)propargyl ethers as rasagiline analogues via chemical or enzymatic resolution of 1-pyrindan-7-ol". RSC Adv. 5 126 (2015): 104509-104515.
    Published • 10.1039/C5RA24868J
  25. Ferreira da Costa, Joana; Caamaño, Olga; Fernández, Franco; García-Mera, Xerardo; Ivo E. Sampaio-Dias; Brea, José Manuel; Cadavid, María Isabel. "Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of l-prolyl-l-leucyl-glycinamide (PLG) modified in the l-proline or l-proline and l-leucine scaffolds". European Journal of Medicinal Chemistry 69 na (2013): 146-158.
    Published • 10.1016/j.ejmech.2013.08.001
Magazine article
  1. Ivo E. Sampaio-Dias. "DynaPro: Avaliação da Quiralidade Dinâmica no Resgate da Melanostatina na Terapia da Parkinson", Química, 2024
Newsletter article
  1. Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Cinco artigos de investigadores da Faculdade de Ciências conquistaram o prémio do programa IACOBUS papers", Notícias Universidade do Porto, 2024, https://noticias.up.pt/fcup/programa-iacobus-papers-premeia-artigos-de-investigadores-da-fcup/.
  2. Ivo E. Sampaio-Dias. Corresponding author: Ivo E. Sampaio-Dias. "Membros do DQB publicam na conceituada revista Green Chemistry", Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 2020, https://dqb.fc.up.pt/index.php/2020/11/artigo-green-chemistry/.
Thesis / Dissertation
  1. Ivo E. Sampaio-Dias. "Enantioselective Synthesis and Biological Evaluation of PLG and GPE Proline Mimetics". PhD, Universidade do Porto Faculdade de Ciências, 2018.
  2. Ivo E. Sampaio-Dias. "Synthesis and Biological Evaluation of PLG Proline Mimetics with Potential Neuroprotective Activity". Master, Universidade do Porto Faculdade de Ciências, 2013.
  3. "Synthesis of New Prolinomimetic Tripeptides with Potential Neuroprotective Activity". Degree, Universidade do Porto Faculdade de Ciências, 2011.

Intellectual property

Patent
  1. J. E. Rodriguez-Borges; de Castro, Baltazar; Ivo E. Sampaio-Dias; Julián Martínez; Perez-Fernandez, Roman; Ruzo, Samuel; Mouriño, Antonio. 2024. "Sila-Analogos de Compuestos de Vitamina D, Metodo de Produccion de Dichos Compuestos y Usos de los Mismos (Patent Granted: ES2946255)". Spain.
    Granted/Issued
  2. J. E. Rodriguez-Borges; de Castro, Baltazar; Ivo E. Sampaio-Dias; Julián Martínez; Perez-Fernandez, Roman; Ruzo, Samuel; Mouriño, Antonio. 2023. "Sila-Análogos da Vitamina D, Métodos de Produção dos Referidos Compostos, Usos dos Mesmos e Composição Farmacêutica Compreendendo os Compostos". Portugal.
    Granted/Issued
  3. J. E. Rodriguez-Borges; de Castro, Baltazar; Ivo E. Sampaio-Dias; Julián Martínez; Ruzo, Samuel; Mouriño, Antonio. 2023. "Sila-Analogues of Vitamin D Compounds, Method of Producing Said Compounds e Uses Thereof".
    Granted/Issued
Provisional application for patent
  1. 2022. "PCT/IB2022/052839: Sila-Analogues of Vitamin D Compounds, Method of Producing Said Compounds and Uses Thereof".
    Protected

Other

Other output
  1. Chemistry in Action ("Química em Acção"). Textbook of laboratory activities within the scope of the "Summer in Project", promoted by Junior University, University of Porto.. 2010. Ivo E. Sampaio-Dias; Maria Luísa do Vale; Filipe Peralta.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01/11 Development of New Neurotherapeutics in Parkinson's Disease Research - A Medicinal Chemistry Approach Semana das Profissões
Colégio Nossa Senhora do Rosário (Porto, Portugal)
2023/11/29 Insights on the Influence of Proline Residue on the Biological Effects of Glypromate Bioconjugates EPI 2023 - XVIII Iberian Peptide Meeting
European Peptide Society (Sesimbra, Portugal)
2023/11/28 Synthesis of Pyridine-Based Melanostatin Derivatives EPI 2023 - XVIII Iberian Peptide Meeting
European Peptide Society (Sesimbra, Portugal)
2023/10/31 Biochemistry and Biotechnology - Medicinal Chemistry Jornadas DQB-DEQ
Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto (Porto, Portugal)
2023/05/03 Exploring Proline's Puckering Effect on the Allosteric Modulatory Activity of Melanostatin Neuropeptide Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto
Associação de Estudantes da Faculdade de Farmácia da Universidade do Porto (Porto, Portugal)
2023/05 Probing (Tri)Phosgene-Free Assembly of Semicarbazides in Aza-Peptide Synthesis 16th Meeting of Young Researchers of University of Porto (IJUP'23)
University of Porto (Porto, Portugal)
2023/05 Tackling Parkinson's disease by modulation of dopamine receptors using chiral nonproteinogenic melanostatin analogs 16th Meeting of Young Researchers of University of Porto (IJUP'23)
University of Porto (Porto, Portugal)
2023/03 Effective Peptide-Based Conjugates for Application in Central Nervous System Disorders ENEQUI - Encontro Nacional de Estudantes de Química
Faculdade de Ciências da Universidade do Porto (Porto, Portugal)
2023/03 Synthesis and Biological Evaluation of Potent Melanostatin Analogs with Application in Parkinson's Disease ENEQUI - Encontro Nacional de Estudantes de Química
Faculdade de Ciências da Universidade do Porto (Porto, Portugal)
2023/02/01 Glypromate Conjugates for Application in Neurodegenerative Diseases SPF Meeting
(Coimbra, Portugal)
2022/12/06 Synthesis, Pharmacological and Toxicological Evaluation of Melanostatin-Based Peptidomimetics to Tackle Parkinson's Disease Simpósio de Investigação da Faculdade de Farmácia da Universidade do Porto
Faculdade de Fármacia da Universidade do Porto (Porto, Portugal)
2022/11/16 Uma Abordagem Bioisostérica na Descoberta de Potentes Análogos da Melanostatina Usando ß-Aminoácidos Congreso Internacional: XXVI Encontro Galego-Portugués de Química
Colégio Oficial de Químicos da Galiza (COLQUIGA) and Associação de Químicos da Galiza (Santiago de Compostela, Spain)
2022/11/16 Discovery of Melanostatin-Based Potent Modulators of the Dopamine D2 Receptors Using Furoic Acids as Proline Surrogates Congreso Internacional: XXVI Encontro Galego-Portugués de Química
Colégio Oficial de Químicos da Galiza (COLQUIGA) and Associação de Químicos da Galiza (Santiago de Compostela, Spain)
2022/11/16 Melanostatin Aza-Peptides as Potent Allosteric Modulators of the Dopamine D2 Receptors Congreso Internacional: XXVI Encontro Galego-Portugués de Química
Colégio Oficial de Químicos da Galiza (COLQUIGA) and Associação de Químicos da Galiza (Santiago de Compostela, Spain)
2022/11/16 A Sustainable Methodology for the Preparation of HIV Protease Inhibitors to Tackle Viral Resistance Congreso Internacional: XXVI Encontro Galego-Portugués de Química
Colégio Oficial de Químicos da Galiza (COLQUIGA) and Associação de Químicos da Galiza (Santiago de Compostela, Spain)
2022/11/01 A Chemical Strategy to Improve Bioavailability of Glypromate Peptide-Conjugates 8th International Electronic Conference on Medicinal Chemistry
Pharmaceuticals (MDPI)
2022/11/01 Synthesis, Pharmacological and Toxicological Evaluation of Potent Melanostatin Peptidomimetics Incorporating Chiral ß-Amino Acids as Proline Surrogates 8th International Electronic Conference on Medicinal Chemistry
Pharmaceuticals (MDPI)
2022/11/01 Coelenterazine Derivatives as Potential Drugs for Photodynamic Therapy 8th International Electronic Conference on Medicinal Chemistry
2022/10/13 Application of Melanostatin-based Modulators of the D2 Receptors in Parkinson's Disease Invited Lecture at Center for Research in Biological Chemistry and Molecular Materials (CiQUS)
ComBioMed Research group, Center for Research in Biological Chemistry and Molecular Materials (CiQUS), Santiago de Compostela, Spain (Santiago de Compostela, Spain)
2022/06/22 Melanostatin Bioisosteres as Modulators of the D2 Receptors with Application in Parkinson's Therapy 20th National Medicinal Chemistry Meeting
Spanish Society of Medicinal Chemistry (Santiago de Compostela, Spain, Spain)
2022 Fostering Chemical Sustainability in HIV Drug Research 15th Meeting of Young Researchers of University of Porto (IJUP'22)
University of Porto (Porto, Portugal)
2022 Synthesis and Pharmacological Evaluation of Melanostatin Peptidomimetics Using ß-Amino Acids as Proline Surrogates with Application in Parkinson's Disease 15th Meeting of Young Researchers of University of Porto (IJUP'22)
University of Porto (Porto, Portugal)
2022 Thiophene-Based Melanostatin (MIF-1) Neuropeptide Analogues by O-to-S Bioisosteric Replacement in MIF-1 Furoyl Peptidomimetics 15th Meeting of Young Researchers of University of Porto (IJUP'22)
University of Porto (Porto, Portugal)
2021/11 Constrained Glypromate® Analogues Incorporating a Bicyclic Proline Surrogate 7th International Electronic Conference on Medicinal Chemistry
Pharmaceuticals (MDPI)
2021/05 A Bioisosteric Approach using Aza-Proline (azPro) as a Proline Surrogate in Melanostatin Neuropeptide 14th Meeting of Young Researchers of the University of Porto (IJUP)
Young Researchers of the University of Porto (IJUP) (Porto, Portugal)
2021/05 Exploring the Role of the N-terminal Amine in Melanostatin Neuropeptide: A Bioisosteric Approach using (S)-Tetrahydro-2-furoic Acid as a Proline Surrogate 14th Meeting of Young Researchers of the University of Porto (IJUP)
Young Researchers of the University of Porto (IJUP) (Porto, Portugal)
2021/03 Synthesis and Pharmacological Evaluation of Novel Melanostatin (MIF-1) Peptidomimetics Using 2-Furoic Acid as a Proline Surrogate Digital Colloquium
National Association of Chemistry Students (ANEQ) (Portugal)
2020/11/03 Norhierridin B, a new hierridin B-based hydroquinone with improved antiproliferative activity 6th International Electronic Conference on Medicinal Chemistry
ECMC2020
2019/11/20 Mechanical Study for the Transprotection of Tertiary Amines using Boc2O: Access to Both Enantiomers of 2-Azanorbornane-3-Exo-Carboxylic Acid (Estudo Mecanístico para a Transproteção de Aminas Terciárias usando Boc2O: Acesso a Ambos os Enantiómeros do Ácido 2-Azanorbornano-3-exo-carboxílico) XXV Encontro Luso-Galego de Química
(Santiago de Compostela, Spain)
2017/09/03 Isolation, Synthesis and Biosynthesis of Hierridin C, a Novel Antiplasmodial Compound from Cyanobium sp. LEGE 06113 10th European Conference on Marine Natural Products
(Crete, Greece)
2017/04/27 The Potential of Bioactive Compounds Analogues of Tripéptides GPE and PLG in the Treatment of Neurodegenerative Diseases 4th PubHD
(Porto, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2024/11/01 - Current Bioisosteric Strategy to Improve the Bioavailability of Melanostatin and Glypromate Neuropeptides for Application in Parkinson's Therapy
Supervisor of António Xavier Vieira da Costa e Cruz Correia
 Chemistry (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2024/09/01 - Current Exploring the Gamma-Lactam-to-Pyrrolidine Replacement in the Modulatory Activity of PAOPA
Supervisor of Tiago Gusmão Guedes Grosjean Dias
 Biochemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2024/09/01 - Current Synthesis and Biological Evaluation of alpha-Alkylated Prolyl Derivates of Melanostatin Neuropeptide
Co-supervisor of Helena Sofia Moreira Teixeira
 Biochemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2024/09/01 - Current Design, Synthesis, and Biological Evaluation of Litocholic Acid Conjugates for Application in Cancer Therapy
Co-supervisor of Maria Beatriz Igreja Cardoso
 Biochemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2023/12/31 - Current Synthesis and Biological Evaluation of Alicyclic Melanostatin and Glypromate Peptidomimetics with Application in Neurodegenerative Diseases
Supervisor of Hugo Filipe Costa Almeida
 Sustainable Chemistry (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2023/10/01 - Current Synthesis, Pharmacological, and Biological Evaluation of Pyridine-Based Melanostatin Derivatives
Co-supervisor of Beatriz Lopes Pires de Lima
 Sustainable Chemistry (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2024/07 - 2025/07 Synthesis of Melanostatin Conjugates with Neuroprotective Amines
Supervisor of Eduardo Grossi de Vicq Ferreira da Costa
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2024/07 - 2025/07 Synthesis of Melanostatin Conjugates with Psychostimulant Amines
Supervisor of Afonso Filipe Moreira de Carvalho
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2024/05/20 - 2024/08/20 Supervisor of a research fellow at REQUIMTE. Fellowship reference: REQUIMTE 2024-15
Supervisor of Sara Carolina Silva Reis
 Research Fellowship (Master)
REQUIMTE LAQV Porto, Portugal
2023/09 - 2024/07/26 Synthesis and Biological Evaluation of New Glypromate Fluorescent Conjugates
Supervisor of Joana Pinto de Oliveira
 Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2023/11 - 2024/07/05 Synthesis and Biological Evaluation of New Melanostatin-Based Peptides Targeting Parkinson's Disease
Supervisor of Bruna Dias Machado da Silva
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2023/11 - 2024/07/05 Synthesis and Biological Evaluation of New Melanostatin-Based Peptides Targeting Parkinson's Disease
Supervisor of Ana Delfim Almeida Torres
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2023/11 - 2024/07/05 Synthesis and Biological Evaluation of New Fluorescent Probes for Neurological Disorders
Supervisor of Joana Pinto de Oliveira
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2023/07 - 2024/06/27 Synthesis of Methylated Peptidomimetics of Melanostatin Neuropeptide
Supervisor of David Afonso Brandão Ferreira
 Technological Course "Chemical-biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2020/01/01 - 2024/06/14 NeuroPro: Peptide Conjugates for Neurodegenerative Diseases using Constrained Prolines
Co-supervisor of Sara Carolina Silva Reis
 Sustainable Chemistry (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2022/09 - 2023/11/22 Synthesis and Biological Evaluation of Melanostatin Aza-peptides for Application in Parkinson's Disease
Supervisor of António Xavier Vieira da Costa e Cruz Correia
 Biochemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2022/09 - 2023/11/22 Synthesis, Pharmacological, and Toxicological Evaluation of Carbamate-Based Melanostatin Analogues With Potential Anti-Parkinson Activity
Supervisor of Hugo Filipe Costa Almeida
 Pharmaceutical Chemistry (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/02/06 - 2023/08/05 Supervisor of a research fellow in the framework of the project "DynaPro: Probing Dynamic Chirality to the Rescue of Melanostatin in Parkinson's Therapy" - Grant reference: 2022.01175.PTDC. Fellowship reference: REQUIMTE 2023-01
Supervisor of António Xavier Vieira da Costa e Cruz Correia
 Research Fellowship (Degree)
REQUIMTE LAQV Porto, Portugal
2023/02/06 - 2023/08/05 Supervisor of a research fellow in the framework of the project "DynaPro: Probing Dynamic Chirality to the Rescue of Melanostatin in Parkinson's Therapy" - Grant reference: 2022.01175.PTDC. Fellowship reference: REQUIMTE 2023-01
Supervisor of Hugo Filipe Costa Almeida
 Research Fellowship (Degree)
REQUIMTE LAQV Porto, Portugal
2023/02 - 2023/07/27 Synthesis and Biological Evaluation of Pyrazine-Based Compounds with Potential Anti-Cancer Activity
Co-supervisor of Tiago Miguel Pinheiro Alves
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2023/02/06 - 2023/07/06 Synthesis of Non-Proteinogenic Amino Acids for Application in Neurological Disorders
Supervisor of Henrique da Rocha Rodrigues
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2023/02/06 - 2023/07/06 Synthesis of Non-Proteinogenic Amino Acids for Application in Neurological Disorders
Supervisor of Joana Pinto de Oliveira
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2022/09/01 - 2023/06/04 Incorporation of 4-Fluoroprolines in Melanostatin and Glypromate Neuropeptides to Study the Proline Puckering Effect on Bioactivity
Supervisor of André Daniel Malta Aires Melo da Cruz
 Technological Course "Chemical-biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2021/09 - 2022/11/22 Synthesis and Pharmacological Evaluation of Melanostatin Hybrid Peptide-Peptoid Derivatives
Co-supervisor of Renata Fontes Santana
 Biochemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2021/09 - 2022/11/22 Synthesis and Pharmacological Evaluation of Melanostatin Macrocyclic Derivatives
Supervisor of Luciano Eduardo Rodrigues dos Santos
 Biochemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2022/07/04 - 2022/07/31 Incorporation of 4-Fluoroprolines in Melanostatin and Glypromate Neuropeptides to Study the Proline Puckering Effect on Bioactivity
Supervisor of André Daniel Malta Aires Melo da Cruz
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
2021/09 - 2022/07/04 Synthesis of Azapeptidomimetics with Potential Anti-Parkinson Activity
Supervisor of Bruno Filipe Oliveira Magalhães
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2022/02 - 2022/07 Synthesis of Racetams For Application in Neurological Disorders
Supervisor of António Xavier Vieira da Costa e Cruz Correia
 Extra-curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências da Nutrição e Alimentação, Portugal
2021/07 - 2022/07 Synthesis and Biological Evaluation of Melanostatin Aza-Derivatives
Supervisor of Bruno Filipe Oliveira Magalhães
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2020/09/17 - 2021/12/02 Synthesis and Pharmacological Evaluation of Melanostatin Isosteres with Potential Anti-Parkinson Activity
Supervisor of Beatriz Lopes Pires de Lima
 Biochemistry (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2021/02/01 - 2021/07/20 Synthesis and Pharmacological Evaluation of Melanostatin Azapeptidomimetics with Potential Anti-Parkinson Activity
Supervisor of António Xavier Vieira da Costa e Cruz Correia
 Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2021/02/01 - 2021/07/14 Synthesis of Cyclic ß-Amino Acids for Application in Anti-Parkinson Peptides
Co-supervisor of Hugo Filipe Costa Almeida
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2020/02/03 - 2020/12 Synthesis of Potential HIV-1 Protease Inhibitors
Supervisor of António Xavier Vieira da Costa e Cruz Correia
 Extra-curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2020/02/03 - 2020/12 Synthesis of Potential HIV-1 Protease Inhibitors
Supervisor of Ana Teresa Gonçalves e Silva
 Extra-curricular Internship Program (PEEC - FCUP) (Scientific initiation)
2020/02 - 2020/09 Synthesis of Gemini-Silylated Precursors of Vitamin D
Co-supervisor of Isabel Santos
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2020/02/03 - 2020/07 Synthesis and Biological Evaluation of Rasagiline Isosteres as Potential Anti-Parkinson Drugs
Supervisor of Gabriel Machado Azevedo
 Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/09 - 2020/07 Synthesis and Biological Evaluation of Levofloxacin Analogues
Supervisor of Filomena Amaral
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2019/09 - 2020 Synthesis and Biological Evaluation of Levofloxacin Analogues
Supervisor of Beatriz Barbosa
 Technological Course "ChemicalBiological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2019/02 - 2019/09 Synthesis of Chiral Precursors of Sila-Derivatives of Vitamin D
Co-supervisor of Beatriz Lopes Pires de Lima
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2019/02 - 2019/07 Synthesis of PTS Derivatives as Potential Reagents in Micellar Catalysis
Co-supervisor of Júlia Gomes
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2018/09 - 2019/07 Synthesis of MIF-1 Analogues using 2-azanorbornane-3-exo-carboxylic acid scaffold as Proline Mimetic
Supervisor of Pedro Moreira
 Technological Course "Chemical-Biological Analyses", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2018/09 - 2019/07 Synthesis of MIF-1 Analogues using 2-azanorbornane-3-exo-carboxylic acid scaffold as Proline Mimetic
Supervisor of Mariana Sousa
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2017/09 - 2018/07 Synthesis and Evaluation of Darunavir Analogues Based on 3-(2-Furoyl)acrylic acid
Supervisor of Guilherme Leal Martinho da Rocha
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2017/09 - 2018/07 Synthesis and Evaluation of Darunavir Analogues Based on 2-Furoic Acid
Supervisor of António Xavier Vieira da Costa e Cruz
 Technological Course "Chemical-Biological Analyses", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2017/02 - 2017/07 Synthesis of PLG and GPE Analogues with Potential Neuroprotective Activity
Co-supervisor of Sara Carolina Silva Reis
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2017/02 - 2017/07 Synthesis and Biological Evaluation of GPE Conjugates with Potential Neuroprotective Activity
Supervisor of Ana Catarina Vieira Dias dos Santos
 Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2016/09 - 2017/07 Contribution to the Synthesis of MIF-1 Peptidomimetics
Supervisor of Catarina Pontes
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2016/09 - 2017/07 Contribution to the Synthesis of MIF-1 Peptidomimetics
Supervisor of Mónica Marques
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
2016/02 - 2016/07 Synthesis of Beta-Amino Acids Derived from Natural Products
Supervisor of Sara Carolina Silva Reis
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2016/02 - 2016/07 Synthesis of Glycyl-L-Prolyl-L-Glutamic Acid Derivatives as Potential Therapeutic Agents
Supervisor of Sara Carolina Silva Reis
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2016/02 - 2016/07 Synthesis of Glycyl-L-Prolyl-L-Glutamic Acid Derivatives as Potential Therapeutic Agents
Supervisor of Cláudia Patrícia Santos Ribeiro
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2015/09 - 2016/07 Contribution to the Synthesis of PLG and GPE Peptidomimetics
Supervisor of Alexandre Filipe Oliveira Pinto
 Technological Course "Chemical-Biological Analyses", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2015/09 - 2016/07 Contribution to the Synthesis of PLG and GPE Peptidomimetics
Co-supervisor of Veridiano Moreno
 Technological Course "Chemical-Biological Analysis", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2015/02 - 2015/09 Synthesis of Novel Tripeptides Derived from Picolinic Acid with Potential Neuroprotective Activity
Co-supervisor of Célio Dinarte Sousa Neves
 Biochemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2015/02 - 2015/07 Synthesis of PLG Analogues Derived From 3-Furoic Acid
Supervisor of Liliana Patrícia Maciel Almeida
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2015/02 - 2015/07 Synthesis of PLG Peptidomimetics Derived from Picolinic Acid
Supervisor of Célio Dinarte Sousa Neves
 Extra-curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2014/09 - 2015/07 Synthesis of PLG Analogues Derived From 2-Furoic Acid
Supervisor of Junjie Lin
 Technological Course "Chemical-Biological Analyses", Colégio de Gaia (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal
2014/02 - 2014/07 Enantioselective Synthesis of Proline Mimetic Cycloadducts Using (-)-8-Phenylmenthol as a Chiral Auxiliary
Co-supervisor of Aline Lukasievicz Chenet
 Chemistry (Degree)
Universidade do Porto Faculdade de Ciências, Portugal
2013/02 - 2013/07 Synthesis of Neuroprotective Tripeptides Mimetics of PLG and GPE
Co-supervisor of Liliana Cristina Moreira Raeiro
 Extra-Curricular Internship Program (PEEC - FCUP) (Scientific initiation)
Universidade do Porto Faculdade de Ciências, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2016/09/23 - 2016/09/26 3rd Iberoamerican Symposium of Organic Chemistry (2016/09/23 - 2016/09/26)
Symposium (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2016/09/05 - 2016/09/07 1st International Symposium on Lipid and Antioxidants (2016/09/05 - 2016/09/07)
Symposium (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal
2016/02/10 - 2016/02/12 15th Iberian Peptide Meeting (2016/02/10 - 2016/02/12)
Meeting (Member of the Organising Committee)
 Universidade do Porto Faculdade de Ciências, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/07/10 - 2023/07/14 Scientific Project with a High School Student - Student's name: Joana Moura dos Santos
Exhibition
 School of Chemistry and Biochemistry 2023
Universidade do Porto Faculdade de Ciências, Portugal
2019/04 - 2019/04 Demonstration of Experiments to High School Students
Exhibition
 Mostra UP
Universidade do Porto, Portugal
2016/09/23 - 2016/09/26 3rd Iberoamerican Symposium of Organic Chemistry
Symposium
 3rd Iberoamerican Symposium of Organic Chemistry
Universidade do Porto Faculdade de Ciências, Portugal
2016/09/05 - 2016/09/07 1st International Symposium on Lipid and Antioxidants
Symposium
 1st International Symposium on Lipid and Antioxidants
Universidade do Porto Faculdade de Ciências, Portugal
2016/03/21 - 2016/03/23 Scientific Project with 4 High School Students
Exhibition
 LabWeek - Semana com a Química
Universidade do Porto Faculdade de Ciências, Portugal
2016/02/18 - 2016/02/19 Open Days - University of Porto
Exhibition
 Dias Abertos da Universidade do Porto
Universidade do Porto Faculdade de Ciências, Portugal
2016/02/10 - 2016/02/12 15th Iberian Peptide Meeting
Meeting
 15th Iberian Peptide Meeting
Universidade do Porto Faculdade de Ciências, Portugal
2016 - 2016 XVI Iberian Peptide Meeting
Meeting
 XVI Encontro Peptídico Ibérico
SPQ, Portugal
2015/07/06 - 2015/07/10 Scientific Project with 4 High School Students
Exhibition
 School of Chemistry and Biochemistry 2015
Universidade do Porto Faculdade de Ciências, Portugal
2014/07/14 - 2014/07/18 Scientific Project with 4 High School Students
Exhibition
 School of Chemistry and Biochemistry 2014
Universidade do Porto Faculdade de Ciências, Portugal
2010/07/01 - 2010/07/30 Demonstration of Experiments to High School Students (Verão em Projecto: Química em Ação)
Exhibition
 Universidade Júnior
Universidade do Porto Faculdade de Ciências, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2024/07/22 Desenvolvimento de Novas Moléculas para a Proteção da Membrana Celular Contra o Stress Oxidativo
(Thesis) Main arguer
 Nathália Silva da Fônseca (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2024/06/14 NeuroPro: Peptide Conjugates for Neurodegenerative Diseases using Constrained Prolines
Supervisor
 Sara Carolina Silva Reis (PhD)
Universidade do Porto Faculdade de Ciências, Portugal
2024/05/10 Multicomponent Strategies for GPCR TArgeting: Allosteric Modulation of Dopamine Receptor D2 and Development of Potent and Selective CB2R agonists
(Thesis) Main arguer
 Carlos Rodríguez García (PhD)
Universidade de Santiago de Compostela, Spain
2023/12/04 Preparação de Membranas de Diálise Bioativas Contendo Novos Antioxidantes Lipofílicos: Caracterização e Biocompatibilidade
(Thesis) Arguer
 Rute Sara Brandão Rebelo (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2023/11/22 Synthesis and Biological Evaluation of Melanostatin Aza-Peptides for Application in Parkinson's Disease
Supervisor
 António Xavier Vieira da Costa e Cruz Correia (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2023/11/22 Synthesis, Pharmacological, and Toxicological Evaluation of Carbamate-Based Melanostatin Analogues with Potential Anti-Parkinson Activity
Supervisor
 Hugo Filipe Costa Almeida (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2023/09/28 Desenvolvimento de Novas Moléculas com Potencial Atividade Protetora das Doenças Cardiovasculares e Neurodegenerativas
(Thesis) Arguer
 Francisca Filipa da Silva Arques (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2023/08/06 A2B Adenosine Receptor as a Novel Target in Cancer Immunotherapy: Validation and Optimization of New Ligands
Thesis Member
 Rubén Prieto Díaz (PhD)
Universidade de Santiago de Compostela, Spain
2022/11/22 Síntese e Avaliação Farmacológica de Derivados Macrocíclicos da Melanostatina
Supervisor
 Luciano Eduardo Rodrigues dos Santos (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2022/11/22 Síntese e Avaliação Farmacológica de Híbridos Péptido-Peptóide da Melanostatina
Supervisor
 Renata Fontes Santana (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2022/11/14 Target-Oriented Synthesis and Evaluation of Chemiluminescent Molecules with Anticancer Activity
(Thesis) Arguer
 José Pedro Araújo e Silva (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2022/07/21 From Synthesis to Pharmacology: An Overview on Melanostatin Peptidomimetics as Allosteric Modulators of the Dopamine D2 Receptors
Supervisor
 Hugo Filipe Costa Almeida (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2022/07/20 Target-Oriented Design of Chemiluminescent Mimetics with Anticancer Activity
(Thesis) Arguer
 João Miguel Gomes de Sousa (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2021/12/14 Bioavailability and anti-inflammatory activity of olive oil polyphenols ("Biodisponibilidade e actividade anti-inflamatória de polifenóis do azeite")
(Thesis) Main arguer
 Vânia Margarida da Silva Costa (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2021/12/02 Synthesis and Pharmacological Evaluation of Melanostatin Isosteres with Potential Anti-Parkinson Activity
Supervisor
 Beatriz Lopes Pires de Lima (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2021/07/20 Synthesis and Pharmacological Evaluation of Melanostatin Azapeptidomimetics with Potential Anti-Parkinson Activity
Supervisor
 António Xavier Vieira Costa Cruz Correia (Other)
2021/07/16 New Ligands and Pharmacological Tools for the study of G Protein-Coupled Receptors Using Multicomponent Reactions
Thesis Member
 Ana Mallo Abreu (PhD)
Universidade de Santiago de Compostela, Spain
2021/07/14 Synthesis of Cyclic ß-Amino Acids for Application in Anti-Parkinson Peptides
Supervisor
 Hugo Filipe Costa Almeida (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2020/12/18 Isolation and Synthesis of Phenols From Olive Oil and Optimization of Their Quantification in Biofluids (Isolamento e Síntese de Fenóis do Azeite e Otimização da sua Quantificação em Biofluídos)
(Thesis) Main arguer
 Sofia Andreia Pires da Silva (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2020/09/10 Synthesis and Biological Evaluation of Rasagiline Isosteres as Potential Anti-Parkinson Drugs
Supervisor
 Gabriel Machado Azevedo (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2020/07/30 Chemical Functionalization of Natural Antocianic Derivatives for Novel Technological Applications
(Thesis) Main arguer
 Ângela Maria da Costa Santos (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2017/07/04 Synthesis and Biological Evaluation of GPE Conjugates with Potential Neuroprotective Activity
Supervisor
 Ana Catarina Vieira Dias dos Santos (Other)
2016/07/22 Synthesis of Glycyl-L-Prolyl-L-Glutamic Acid Derivatives as Potential Therapeutic Agents
Supervisor
 Sara Carolina Silva Reis (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2016/07/22 Synthesis of Glycyl-L-Prolyl-L-Glutamic Acid Derivatives as Potential Therapeutic Agents
Supervisor
 Cláudia Patrícia Santos Ribeiro (Other)
Universidade do Porto Faculdade de Ciências, Portugal
2015/07 Synthesis of New Tripeptides Derived from Picolinic Acid with Potential Neuroprotective Activity
Supervisor
 Célio Dinarte Sousa Neves (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Ad Hoc journal article review

Journal title (ISSN) Publisher
2024/05/21 - Current Bioorganic Chemistry (0045-2068) Elsevier
2023/01 - Current Chemistry Select Wiley-VCH GmbH, Weinheim
2022/11 - Current Tetrahedron Letters Elsevier
2022/08/03 - Current RSC Advances Royal Society of Chemistry
2022/08/03 - Current Organic Chemistry Frontiers (2052-4129) Royal Society of Chemistry

Association member

Society Organization name Role
2023/11/30 - Current Portuguese Chemical Society (SPQ) Effective member
2016 - Current The European Peptide Society Regular member

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021 - Current Laboratory classes (tutor) within the scope of the Curricular Unit "Synthesis of Drugs" (Master in Chemistry/Biochemistry) Chemistry (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2022/11/21 - 2022/11/21 Invited Lecture: Greener Approaches in Peptide Synthesis for the Assembly of Bioactive Peptides (within the scope of the Curricular Unit "Synthesis of Bioproducts", Master in Applications in Biotechnology and Synthetic Biology) Applications in Biotechnology and Synthetic Biology (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2021/11/22 - 2021/11/22 Invited Lecture: Greener Approaches in Peptide Synthesis for the Assembly of Bioactive Peptides (within the scope of the Curricular Unit "Synthesis of Bioproducts", Master in Applications in Biotechnology and Synthetic Biology) Applications in Biotechnology and Synthetic Biology (Mestrado) Universidade do Porto Faculdade de Ciências, Portugal
2019/02 - 2021/09 Applied Organic Chemistry (Química Orgânica Aplicada) Pharmacy (Farmácia) (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2019/02 - 2019/07 Biomaterials and Biocompatibility (Biomateriais e Biocompatibilidade) Medicinal Biotechnology (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2018/09 - 2019/02 Biological Chemistry I (Química Biológica I) Medicinal Biotechnology (Biotecnologia Medicinal) (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2018/09 - 2019/02 Biological Physical Chemistry (Química-Física Biológica) Medicinal Biotechnology (Biotecnologia Medicinal) (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2018/12 - 2018/12 Seminars in Applied Biochemistry (Seminários em Bioquímica Aplicada) Biochemistry in Health (Bioquímica em Saúde) (Mestrado integrado) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2018/02 - 2018/07 Integrated Laboratory Practices II (Práticas Laboratoriais Integradas II) Pharmacy (Farmácia) (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal
2017/09 - 2018/02 Integrated Laboratory Practices I (Práticas Laboratoriais Integradas I) Pharmacy (Farmácia) (Licenciatura) Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Interview (newspaper / magazine)

Activity description Newspaper / Forum
2024/10 PepTRAP: uma abordagem farmacológica inovadora para combater a doença de Parkinson Universidade do Porto Inovação
2024/06 DynaPro: Avaliação da Quiralidade Dinâmica no Resgate da Melanostatina na Terapia da Parkinson Química
2024/04/11 "Cientistas da FCUP estudam novo fármaco para o tratamento do Parkinson" "FCUP scientists study new drug to treat Parkinson's" Notícias Universidade do Porto / Agência Lusa

Interview (tv / radio show)

Program Topic
2024/07/16 - 2024/07/16 90 segundos de Ciência Projeto DynaPro Desenvolve Terapia Alternativa para a Doença de Parkinson

Journal scientific committee

Journal title (ISSN) Publisher
2023/09/11 - Current Associate Editorial Board Member of "Current Medicinal Chemistry" (1875-533X) Bentham Science Publishers

Other jury / evaluation

Activity description Institution / Organization
2024/05/02 - Current Selection Juri (President) for a researcher position at REQUIMTE, funded by FCT. Ref. REQUIMTE 2024-15 REQUIMTE LAQV Porto, Portugal
2024/05/17 - 2024/05/17 External Reviewer Doctoratus Europeus | PhD Student: Giovanni Gaziano | Thesis: Rational Design and Optimization of Anthranil Amide Derivatives as New Cannabinoid 2 Receptor Selective Ligands Università degli Studi di Bari Aldo Moro Dipartimento di Farmacia Scienze del Farmaco, Italy
2023/07/17 - 2023/07/17 External Reviewer Doctoratus Europeus | PhD Student: Rubén Prieto Díaz | Thesis: A2B Adenosine Receptor as a Novel Target in Cancer Immunotherapy: Validation and Optimization of New Ligands Universidade de Santiago de Compostela Facultade de Farmacia, Spain
2023/01/18 - 2023/01/18 Selection Juri (President) for a researcher position in the framework of the Project "DynaPro: Probing Dynamic Chirality to the Rescue of Melanostatin in Parkinson's Therapy", with reference 2022.01175.PTDC, funded by FCT. Ref. REQUIMTE 2023-01 (Position: 1) REQUIMTE LAQV Porto, Portugal
2023/01/18 - 2023/01/18 Selection Juri (President) for a researcher position in the framework of the Project "DynaPro: Probing Dynamic Chirality to the Rescue of Melanostatin in Parkinson's Therapy", with reference 2022.01175.PTDC, funded by FCT. Ref. REQUIMTE 2023-01 (Position 2) REQUIMTE LAQV Porto, Portugal
2022/07 - 2022/07 Professional Aptitude Evaluation entitled "Synthesis and Biological Evaluation of Melanostatin Aza-Derivatives" Student's name: Bruno Filipe Oliveira Magalhães | Role: Supervisor
Distinctions

Award

2024 IACOBUS Research Papers Award
European Grouping of Territorial Cooperation Galicia - Norte de Portugal (GNP-EGTC), Spain
2024 Best Poster Presentation
Sociedad Española de Química Terapéutica (SEQT), Spain
2024 Best Flash Poster Presentation
Sociedad Española de Química Terapéutica (SEQT), Spain
2024 BIP PROOF - support program for developing proofs of concept by the University of Porto.
Universidade do Porto, Portugal
2024 1st Place in the 2024 Photography Contest | FCUP Campus: Our View
Universidade do Porto Faculdade de Ciências, Portugal
2023 Best Oral Communication
Simpósio de Investigação da Faculdade de Fármacia da Universidade do Porto, Portugal
2023 Best Poster Presentation
Sociedad Española de Química Terapéutica (SEQT), Spain
2022 Best Oral Communication
Simpósio de Investigação da Faculdade de Fármacia da Universidade do Porto, Portugal
2022 Best Oral Communication
XV Meeting of Young Researchers of the Uninversity of Porto (IJUP), Portugal
2022 IACOBUS Patents Award
European Grouping of Territorial Cooperation Galicia - Norte de Portugal (GNP-EGTC), Spain
2021 Best Oral Communication
XIV Meeting of Young Researchers of the University of Porto (IJUP), Portugal
2021 Best Poster Presentation
XIV Meeting of Young Researchers of the University of Porto (IJUP), Portugal
2018 EPS bursary for participation in 35EPS
European Peptide Society, United Kingdom

Other distinction

2022 Invited Visiting Scientist
Centro Singular de Investigación en Química Biológica y Materiales Moleculares, Spain