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João Luís Neto is currently a posdoctoral fellow working on genomics, transcriptomics and bioinformatics in oncobiology at Instituto de Medicina Molecular João Lobo Antunes (Lisboa, Portugal). In 2018 he was a postdoctoral research associate working in bioinformatics at the UK Dementia Research Institute at University College London (London, UK). He has a PhD in Basic and Applied Biology (University of Porto, 2017) and performed his doctoral studies at the Center for Genomic Medicine at the Massachusetts General Hospital (Boston, MA, USA). João has published 8 articles in peer-reviewed journals, has 1 paper currently under review and 2 in preparation. He has received 2 awards for presentations of previous work. In recent years João has shown a broad professional adaptability and learning ability in different areas, switching from a mainly wet lab scientist to a bioinformatician (in 2018), and from working in neurodegenerative disorders to oncobiology (2019 and onward).
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Identification

Personal identification

Full name
João Luís Aguiar Martins Neto

Citation names

  • João Luís Neto
  • João L. Neto

Author identifiers

Ciência ID
E512-57B7-6129
ORCID iD
0000-0003-0863-158X

Knowledge fields

  • Exact Sciences - Computer and Information Sciences - Bioinformatics
  • Medical and Health Sciences - Clinical Medicine - Oncology
  • Medical and Health Sciences - Basic Medicine - Immunology
  • Medical and Health Sciences - Basic Medicine - Human Genetics
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Biochemistry

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2017
Concluded
 Biologia Básica e Aplicada (Doutoramento)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
"CAG repeat instability in Huntington´s disease: insights from HD patients and mouse models" (THESIS/DISSERTATION)
 Aprovado
2010
Concluded
 Bioquímica (Mestrado)
Universidade do Porto Faculdade de Ciências, Portugal
"The role of synaptic vesicles’ molecular machinery encoding genes in migraine susceptibility" (THESIS/DISSERTATION)
 18
2008
Concluded
 Bioquímica (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
"Enxaqueca: Determinação de factores de susceptibilidade por estudos de associação" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2019/02 - 2021/08 Postdoc (Research) Instituto de Medicina Molecular, Portugal
2018/04 - 2018/12 Postdoc (Research) University College London Institute of Neurology, United Kingdom
UK Dementia Research Institute, United Kingdom
2012/01 - 2017/10 Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2012/01 - 2017/10 Researcher (Research) Massachusetts General Hospital Center for Genomic Medicine, United States
2011/01 - 2011/12 Research Assistant (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008/09 - 2010/12 Research Trainee (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2008/02 - 2008/09 Research Trainee (Research) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Others

Category
Host institution 		Employer
2012/01 - 2017/10 PhD student Massachusetts General Hospital Center for Genomic Medicine, United States
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2004/08 - 2005/06 Student trainee at company CLINAQUA, Laboratório de Análises de Águas, Portugal
Projects

Grant

Designation Funders
2019/02/01 - Current IL-7/IL-7R signaling networks in health and malignancy
info:eu-repo/grantAgreement/EC/H2020/648455/EU
Post-doc Fellow
European Commission
Ongoing
2011/02/01 - 2011/12/31 Mutational spectrum and improvement in laboratory techniques applied to molecular diagnosis of neurological disorders
PIC/IC/83232/2007
Research Fellow
Concluded
Outputs

Publications

Conference poster
  1. Santos, M.; Carmona, S.; Neto, João Luís; Damásio, J.; Sequeiros, J.; Barbot, C.; Coutinho, P.; et al. "Identifying novel KIF1C-cerebellar ataxia variants by exome sequencing and molecular characterization". Paper presented in European Human Genetics Conference (ESHG 2019), 2019.
  2. Neto, João Luís; Lee, J. M.; Gillis, T.; Guide, J. R.; Lager, B.; Dempsey, S.; Alonso, I.; Wheeler, V. C.; Mouro-Pinto, R.. "Intergenerational instability in Huntington’s disease: insights from mice models". Paper presented in HD2016: Hereditary Disease Foundation Symposium, 2016.
  3. Neto, João Luís; Lee, J. M.; Gillis, T.; Guide, J. R.; Lager, B.; Alonso, I.; Wheeler, V. C.; Mouro-Pinto, R.. "Intergenerational instability in Huntington’s disease: insights from mice models". Paper presented in 49th European Human Genetics Conference (ESHG 2016), 2016.
  4. Neto, João Luís; Mouro-Pinto, R.; Anderson, M. A.; Ruliera, J.; Mysore, J.; Gillis, T.; MacDonald, M. E.; et al. "Novel characterization of CAG repeat instability in Huntington’s disease (HD) patientderived lymphoblastoid cell line and sperm DNA.". Paper presented in MGH Executive Committee On Research (ECOR) Scientific Advisory Committee Meeting, 2016.
  5. Neto, João Luís; Wheeler, V. C.; Mouro-Pinto, R.. "Intergenerational instability in Huntington’s Disease: insights from mouse models". Paper presented in MGH Executive Committee On Research (ECOR) Scientific Advisory Committee Meeting, 2015.
  6. Neto, João Luís; Biagioli, M.; Mouro-Pinto, R.; Guide, J.; St. Claire, J.; Kovalenko, M.; Alonso, I.; Wheeler, V. C.. "‘ChIPing’ away: looking for chromatin modifications in Huntington’s disease knock-in mice models.". Paper presented in Center for Human Genetic Research 2014 Retrea, 2014.
  7. Santos, D.; Coelho, T.; Neto, João Luís; Pinto-Basto, J.; Sequeiros, J.; Alonso, I.; Lemos, C.; Sousa, A.. "The role of APCS and RBP4 genes as modifiers of age-at-onset in Familial Amyloid Polyneuropathy (FAP ATTRV30M)". Paper presented in American Society of Human Genetics (ASHG) 62nd Annual Meeting, 2012.
  8. Neto, João Luís; Lemos, C.; Pereira-Monteiro, J.; Sequeiros, J.; Sousa, A.; Alonso, I.. "Genetic variation in SNAP25 is involved in common migraine susceptibility.". Paper presented in 16th Portuguese Society of Human Genetics (SPGH) Meeting, 2012.
  9. Lemos, C.; Coelho, T.; Santos, D.; Neto, João Luís; Alves-Ferreira, M.; Pinto-Basto, J.; Sequeiros, J.; Alonso, I.; Sousa, A.. "Variability in age-at-onset of familial amyloid polyneuropathy (FAP ATTRV30M): an extended haplotype effect?". Paper presented in European Human Genetics Conference 2012, 2012.
  10. Santos, D.; Coelho, T.; Neto, João Luís; Pinto-Basto, J.; Sequeiros, J.; Alonso, I.; Lemos, C.; Sousa, A.. "APCS and RBP4: possible modifiers of age-at-onset in familial amyloid polyneuropathy (FAP ATTRV30M)". Paper presented in European Human Genetics Conference 2012, 2012.
  11. Vaz-Osório, S.; Neto, João Luís; Pereira-Monteiro, J.; Barros, J.; Sequeiros, J.; Sousa, A.; Alonso, I.; Lemos, C.. "The role of genes involved in neurogenic inflammation as susceptibility factors for migraine". Paper presented in European Human Genetics Conference 2012, 2012.
  12. Quintas, M.; Neto, João Luís; Pereira-Monteiro, J.; Barros, J.; Sequeiros, J.; Sousa, A.; Alonso, I.. "Migraine susceptibility factors: the role of GABA genes in females’ liability". Paper presented in European Human Genetics Conference 2012, 2012.
  13. Neto, João Luís; Alonso, I.; Wheeler, V. C.. "The role of epigenetic modifiers in Huntington disease trinucleotide instability". Paper presented in GABBA Program 16th Annual Scientific Meeting, 2012.
  14. Sousa, A.; Lemos, C.; Martins-da-Silva, A.; Magalhães, R.; Neto, João Luís; Alonso, I.; Pinto-Basto, J.; Sequeiros, J.; Coelho, T.. "Familial amyloid polyneuropathy (ATTRV30M): what can we learn from the study of families of this AD disorder in which the proband had no affected parent at the time of diagnosis?". Paper presented in 12th International Congress of Human Genetics (ICHG) / 61st Annual Meeting of the American Society of Human Genetics (ASHG), 2011.
  15. Santos, D.; Coelho, T.; Neto, João Luís; Pinto-Basto, J.; Sequeiros, J.; Alonso, I.; Lemos, C.; Sousa, A.. "Searching for modifiers of age-at-onset in familial amyloid polyneuropathy (FAP) ATTRV30M: a candidate gene approach". Paper presented in 12th International Congress of Human Genetics (ICHG) / 61st Annual Meeting of the American Society of Human Genetics (ASHG), 2011.
  16. Neto, João Luís; Lemos, C.; Coelho, T.; Pinto-Basto, J.; Sequeiros, J.; Alonso, I.; Sousa, A.. "The role of cis-acting genetic modifiers in phenotypic variability of familial amyloid polyneuropathy ATTRV30M". Paper presented in 12th International Congress of Human Genetics (ICHG) / 61st Annual Meeting of the American Society of Human Genetics (ASHG), 2011.
  17. Neto, João Luís; Lemos, C.; Pereira-Monteiro, J.; Sequeiros, J.; Sousa, A.; Alonso, I.. "Common variation in the SNAP25 gene and migraine predisposition". Paper presented in 15th Congress of the International Headache Society, 2011.
  18. Neto, João Luís; Lemos, C.; Pereira-Monteiro, J.; Sequeiros, J.; Sousa, A.; Alonso, I.. "The role of the STXBP1 and UNC13B genes in migraine susceptibility.". Paper presented in i3S Scientific Retreat, 2011.
  19. Lemos, C.; Coelho, T.; Neto, João Luís; Pinto-Basto, J.; Sequeiros, J.; Alonso, I.; Sousa, A.. "Can variability of age-atonset in familial amyloid polyneuropathy ATTRV30M be explained by cis-acting genetic modifiers?". Paper presented in i3S Scientific Retreat, 2011.
  20. Neto, João Luís; Lemos, C.; Pereira-Monteiro, J.; Sequeiros, J.; Sousa, A.; Alonso, I.. "The role of the STXBP1 and UNC13B genes in migraine susceptibility". Paper presented in 14th Portuguese Society of Human Genetics (SPGH) Meeting, 2010.
  21. Lemos, C.; Neto, João Luís; Pereira-Monteiro, J.; Mendonça, D.; Barros, J.; Sequeiros, J.; Alonso, I.; Sousa, A.. "Association of endothelin receptor type A and migraine without aura in a group of Portuguese patients". Paper presented in American Society of Human Genetics (ASHG) 60th Annual Meeting, 2010.
  22. Neto, João Luís; Lemos, C.; Pereira-Monteiro, J.; Sequeiros, J.; Sousa, A.; Alonso, I.. "Synaptic vesicles related genes and migraine predisposition". Paper presented in American Society of Human Genetics (ASHG) 60th Annual Meeting, 2010.
  23. Lemos, C.; Neto, João Luís; Pereira-Monteiro, J.; Mendonça, D.; Barros, J.; Sequeiros, J.; Alonso, I.; Sousa, A.. "A variant in EDNRA is associated with migraine without aura in a group of Portuguese patients". Paper presented in European Human Genetics Conference 2010, 2010.
  24. Neto, João Luís; Lemos, Carolina; Pereira-Monteiro, J.; Sequeiros, J.; Alonso, I.. "Assessment of the role of synaptic vesicles' molecular machinery encoding genes in migraine susceptibility". Paper presented in i3S Scientific Retreat, 2010.
  25. Lemos, C.; Neto, João Luís; Mendonça, D.; Pereira-Monteiro, J.; Ramos, E. M.; Barros, J.; Sequeiros, J.; Alonso, I.; Sousa, A.. "Unravelling susceptibility factors for migraine". Paper presented in i3S Scientific Retreat, 2010.
Journal article
  1. "Molecular Characterization of Portuguese Patients with Hereditary Cerebellar Ataxia". Cells 11 6 (2022): 981-981. http://dx.doi.org/10.3390/cells11060981.
    10.3390/cells11060981
  2. Almeida, Afonso R. M.; Neto, João L.; Cachucho, Ana; Euzébio, Mayara; Meng, Xiangyu; Kim, Rathana; Fernandes, Marta B.; et al. "Interleukin-7 receptor a mutational activation can initiate precursor B-cell acute lymphoblastic leukemia". Nature Communications 12 1 (2021): http://dx.doi.org/10.1038/s41467-021-27197-5.
    10.1038/s41467-021-27197-5
  3. Gabriela M Almeida; Carla Pereira; Ji-Hyeon Park; Carolina Lemos; Sofia Campelos; Irene Gullo; Diana Martins; et al. "CD44v6 High Membranous Expression Is a Predictive Marker of Therapy Response in Gastric Cancer Patients". Biomedicines (2021): https://www.mdpi.com/2227-9059/9/9/1249.
    10.3390/biomedicines9091249
  4. Alves-Ferreira, Miguel; Quintas, Marlene; Sequeiros, Jorge; Sousa, Alda; Pereira-Monteiro, José; Alonso, Isabel; Neto, João Luís; Lemos, Carolina. "A genetic interaction of NRXN2 with GABRE, SYT1 and CASK in migraine patients: a case-control study". The Journal of Headache and Pain 22 1 (2021): http://dx.doi.org/10.1186/s10194-021-01266-y.
    10.1186/s10194-021-01266-y
  5. Silva, Ana Patricia; Almeida, Afonso R.M.; Cachucho, Ana; Neto, João L; Demeyer, Sofie; Ramos de Matos, Mafalda; Hogan, Thea; et al. "Overexpression of wild type IL-7Ra promotes T-cell acute lymphoblastic leukemia/lymphoma". Blood (2021): http://dx.doi.org/10.1182/blood.2019000553.
    10.1182/blood.2019000553
  6. Kovalenko, Marina; Erdin, Serkan; Andrew, Marissa A; St Claire, Jason; Shaughnessey, Melissa; Hubert, Leroy; Neto, João Luís; et al. "Histone deacetylase knockouts modify transcription, CAG instability and nuclear pathology in Huntington disease mice". eLife 9 (2020): http://dx.doi.org/10.7554/elife.55911.
    10.7554/elife.55911
  7. Quintas, Marlene; Neto, João Luís; Sequeiros, Jorge; Sousa, Alda; Pereira-Monteiro, José; Lemos, Carolina; Alonso, Isabel. "Going Deep into Synaptic Vesicle Machinery Genes and Migraine Susceptibility – A Case-Control Association Study". Headache: The Journal of Head and Face Pain 60 10 (2020): 2152-2165. http://dx.doi.org/10.1111/head.13957.
    10.1111/head.13957
  8. Guerreiro, Rita; Escott-Price, Valentina; Hernandez, Dena G.; Kun-Rodrigues, Celia; Ross, Owen A.; Orme, Tatiana; Neto, Joao Luis; et al. "Heritability and genetic variance of dementia with Lewy bodies". Neurobiology of Disease 127 (2019): 492-501. http://dx.doi.org/10.1016/j.nbd.2019.04.004.
    10.1016/j.nbd.2019.04.004
  9. Guerreiro, Rita; Orme, Tatiana; Neto, João Luís; Bras, Jose; Hardy, John; Kun-Rodrigues, Celia; Darwent, Lee; et al. "LRP10 in a-synucleinopathies". The Lancet Neurology 17 12 (2018): 1032-1033. http://dx.doi.org/10.1016/s1474-4422(18)30399-5.
    10.1016/s1474-4422(18)30399-5
  10. Neto, João Luís; Lee, Jong-Min; Afridi, Ali; Gillis, Tammy; Guide, Jolene R.; Dempsey, Stephani; Lager, Brenda; et al. "Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington’s Disease Knock-In Mice". Genetics 205 2 (2016): 503-516. http://dx.doi.org/10.1534/genetics.116.195578.
    10.1534/genetics.116.195578
  11. Quintas, Marlene; Neto, João Luís; Pereira-Monteiro, José; Barros, José; Sequeiros, Jorge; Sousa, Alda; Alonso, Isabel; Lemos, Carolina. "Interaction between gamma-Aminobutyric Acid A Receptor Genes: New Evidence in Migraine Susceptibility". PLoS ONE 8 9 (2013): e74087. http://dx.doi.org/10.1371/journal.pone.0074087.
    10.1371/journal.pone.0074087
  12. Lemos, C.; Neto, J. L.; Pereira-Monteiro, J.; Mendonça, D.; Barros, J.; Sequeiros, J.; Alonso, I.; Sousa, A.. "A role for endothelin receptor type A in migraine without aura susceptibility? A study in Portuguese patients". European Journal of Neurology 18 4 (2010): 649-655. http://dx.doi.org/10.1111/j.1468-1331.2010.03239.x.
    10.1111/j.1468-1331.2010.03239.x
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/10 Overexpression of wild type IL-7Ra and Notch1 mutations cooperate to promote T-cell acute lymphoblastic leukemia iMM Computational Biology and Bioinformatics Day
2020/03 IL7R mutational activation drives precursor B-cell acute lymphoblastic leukemia iMM scientific retreat
2016/12 Intergenerational and somatic repeat instability in knock-in mice models of Huntington’s disease GABBA Program 20th Annual Scientific Meeting
2015/12 Characterizing CAG repeat instability in Huntigton’s Disease (HD) patient-derived lymphoblastoid cell lines (LCLs) GABBA Program 19th Annual Scientific Meeting
2014/12 Multiple approaches toward disentangling CAG instability in Huntington’s disease. GABBA Program 18th Annual Scientific Meeting
2013/12 ChIPing’ away: looking for chromatin modifications in Huntington’s disease knock-in mice models GABBA Program 17th Annual Scientific Meeting
2011/11 Investigação de polimorfismos em genes envolvidos na inflamação neurogénica como factores de susceptibilidade para enxaqueca. Portuguese Headache Society Autumn Meeting
2011/11 O papel dos genes ligados ao cromossoma X na susceptibilidade à enxaqueca. Portuguese Headache Society Autumn Meeting
2010/04 Papel das vesículas sinápticas na susceptibilidade à enxaqueca Portuguese Headache Society Spring Meeting
2010/02 The role of synaptic vesicles in migraine susceptibility IJUP 2010
2009/04 How to search for variants associated with increased susceptibility of migraine? Portuguese Headache Society Spring Meeting
2009/04 Association of EDNRA with migraine without aura in a group of Portuguese patients. Portuguese Headache Society Autumn Meeting

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2012/01 - 2012/07 Organizing Committee - GABBA Annual Symposium "Patterns in life: Deciphering the Code of Nature" (2012/07/06)
Conference (Member of the Organising Committee)

Committee member

Activity description
Role 		Institution / Organization
2008/09 - 2010/07 Student representative in the Biochemistry MSc (University of Porto) scientific committee
Distinctions

Award

2011 1st place of the Tecnifar Headache Award
Sociedade Portuguesa de Cefaleias, Portugal

Tecnifar, Portugal
2010 1st place of the Tecnifar Headache Award
Sociedade Portuguesa de Cefaleias, Portugal

Tecnifar, Portugal