JORGE MANUEL ROLO PEDROSA (E51B-E91E-D2FF)

Curriculum Vitae

JORGE MANUEL ROLO PEDROSA

Jorge Pedrosa, born in 1964, holds a degree in Biochemistry and a PhD in Biomedical Sciences. Jorge Pedrosa is a Full Professor at the School of Medicine (EM) - University of Minho (UM) and a Principal Investigator at the Inflammasignal team at the Life and Health Sciences Research Institute (ICVS) - UM. Presently, JP serves as President of the Portuguese Society of Microbiology (SPM), President of the Clinical Academic Center 2CA - Braga, President of B.ACIS (Tech transfer office, EM UMinho), Coordinator of the InflammaSignal Research Team/ICVS and member of the Scientific Council of the Lusófona Platform for Clinical Research and Biomedical Innovation. His research interests are in the field of Health Sciences-Immunology and he is particularly interested in the host immune response against infections by highly virulent mycobacteria, namely Mycobacterium ulcerans, the causative agent of the emergent tropical disease Buruli ulcer, and Mycobacterium tuberculosis, the causative agent of tuberculosis. He is using animal models in Biosafety Level 3 laboratories and collaborating with a network of health care institutions in Portugal and in Africa, to both evaluate new strategies aiming at the modulation of the host immune response (e.g. design of new vaccines) and to develop new systems of specific delivery of antimicrobial agents to infected cells. Jorge Pedrosa has published 77 peer-reviewed research articles, with an h-index of 33 and that have been cited more than 3000 times. He has supervised 11 PhD-Students and 3 MSc. His main Research Contributions include: - First demonstration of a protective role played by neutrophils in the early phase of experimental tuberculosis. - First isolation from the environment of a pure culture of M. ulcerans, the causative agent of the emergent infectious disease Buruli ulcer, implicating the involvement of aquatic insects in the transmission of this neglected disease. - Characterization of the host inflammatory response to M. ulcerans; - First description of an intracellular growth phase for M. ulcerans, as well as of the mechanisms of macrophage-mediated immune control for this pathogen.

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Identification

Personal identification

Full name: JORGE MANUEL ROLO PEDROSA

Citation names

Pedrosa, Jorge

Author identifiers

Ciência ID: E51B-E91E-D2FF
ORCID iD: 0000-0002-8204-4888

Knowledge fields

Medical and Health Sciences - Basic Medicine - Immunology
Medical and Health Sciences - Health Sciences - Infectious Diseases

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
Portuguese (Mother tongue)

Education

	Degree	Classification
1996 - 1999 Concluded	Ciências Biomédicas (Doutoramento) Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
1994 Concluded	Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal
1986 Concluded	Anatomia Patológica, Citológica e Tanatológica (Bacharelato) Escola Superior de Tecnologias da Saúde do Porto, Portugal

Affiliation

Science

	Category Host institution	Employer
2001 - Current	Principal Investigator (Research)	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2009 - Current	Full Professor (University Teacher)	Universidade do Minho Escola de Medicina, Portugal

2005 - 2009	Associate Professor (University Teacher)	Universidade do Minho Escola de Medicina, Portugal

2000 - 2005	Assistant Professor (University Teacher)	Universidade do Minho Escola de Medicina, Portugal

1992 - 1997	Visiting Teacher (Polytechnic Teacher)	Instituto Politécnico do Porto Escola Superior de Saúde, Portugal

Positions / Appointments

	Category Host institution	Employer
2024/07/31 - Current	Organic Unit President	2CA-Braga, Portugal
	2CA-Braga, Portugal
2019 - Current	Organic Unit President	B.ACIS Associação Ciência, Inovação e Saúde, Portugal

2019 - 2021	Organic Unit Vice-President	Universidade do Minho Escola de Medicina, Portugal

2010 - 2019	Organic Unit Director	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
	Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Others

	Category Host institution	Employer
1986 - 1996	Técnico de Diagnóstico e Terapêutica de 2ª Classe	Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal

Projects

Grant

	Designation	Funders
2007/07 - 2010/06	New perspectives in the neurobiology of depression: beyond the ¿neurochemical hypothesis¿ 72699 Provided by PTCRIS: 72699 PTDC/SAU-NEU/72699/2006 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Contract

	Designation	Funders
2021/01/01 - 2025/12/31	ICVS/3B¿s - Laboratório Associado, Instituto de Ciências da Vida e da Saúde / Grupo de Investigação em Biomateriais, Biodegradaveis e Biomiméticos LA/P/0050/2020 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2023 - 2025	In vitro screening-based selection and in vivo efficacy evaluation of bacteriophages as potential new assets in the topical treatment of Buruli Ulcer disease. GSK Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	GlaxoSmithKline España Ongoing
2023/03/01 - 2024/08/31	Immunometabolic requirements in Buruli Ulcer 10.54499/2022.05266.PTDC Researcher Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2022 - 2024	Extracellular Vesicles as Potential Biomarkers in Fabry Disease Progression Amicus Therapeutics Principal investigator	Amicus Therapeutics SLU Ongoing
2022 - 2024	A Flexible Platform for Generating Synthetic Virus to Control Infectious Diseases La Caixa Foundation Researcher	Caixa d'Estalvis i Pensions de Barcelona Ongoing
2021 - 2022	Buruli Ulcer - Family-Based Whole Exome Sequencing 2CA Researcher	2CA-Braga Concluded
2018 - 2021	lmmunogenetic determinants of susceptibility/resistance to Buruli ulcer: a family- and population-based study for a neglected tropical disease POCI-01-0145-FEDER-031312 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2019/01/01 - 2019/12/31	ICVS/3B¿s - Associate Laboratory, Life and Health Sciences Research Institute / Biomaterials, Biodegradables and Biomimetics Research Group UID/Multi/50026/2019 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2016/01 - 2019/12	Transcriptome Analysis of Animal Models of Spontaneous Healing of Buruli Ulcer Infect-Era-002 Principal investigator	ERA-Net Cofund scheme Concluded
2016 - 2019	SynPhage: Construction of synthetic phages to combat infectious bacterial diseases. PTDC/BBB-BSS/6471/2014 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2016 - 2019	Development of a novel colour-coded RING FISH method: an innovative tool for the detection of antibiotic resistant clinical pathogens. PTDC/DTP-PIC/4562/2014 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2013	BURULIVAC: identification and development of a vaccine against Buruli Ulcer. 241500 Researcher	European Commission Seventh Framework Programme for Research and Technological Development
2011/01/01 - 2012/12/31	Strategic Project - LA 26 - 2011-2012 PEst-C/SAU/LA0026/2011 Universidade do Minho, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009 - 2012	Buruli Ulcer - From the understanding of the mechanisms of host resistance to the development of new interventions against an emergent mycobacteriosis. Proc.Nº 94776 Principal investigator	Fundação Calouste Gulbenkian
2008/01/01 - 2011/12/31	Nanoestruturas Endereçadas para Imagem Molecular Médica Multimodal PTDC/QUI/70063/2006 Universidade do Minho, Portugal Universidade de Coimbra, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/07/01 - 2011/06/30	NanoMeDiag-Plataformas nanobioanalíticas para diagnóstico médico de infeccções provocadas por microorganismos patogénicos NANO/NMed-SD/0076/2007 Universidade do Minho, Portugal Centro de Física das Universidades do Minho e do Porto, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/07/01 - 2010/12/31	ELUCIDAÇÃO DE MECANISMOS PATOLÓGICOS ASSOCIADOS A FORMA JUVENIL DA LIPOFUSCINOSE CERÓIDE NEURONAL: DO MODELO DE LEVEDURA PARA SISTEMAS MAIS COMPLEXOS PTDC/SAU-NEU/70161/2006 Universidade do Minho, Portugal Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2009	Role of Interleukin-23 (IL-23) and IL-17 in the regulation of the immune response to the infection by Mycobacterium tuberculosis PTDC/SAU-MII/70895/2006 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2003 - 2005	Impact of difficult-to-treat mycobacterioses in public health: multi-drug resistant tuberculosis and Buruli Ulcer Proc. Nº 55762 Principal investigator	Fundação Calouste Gulbenkian Concluded

Outputs

Publications

Book chapter

Foulon, Mélanie; Fraga, Alexandra G.; Yeramian, Edouard; Pedrosa, Jorge; Marsollier, Laurent. "Multiple facets and functions of the toxin mycolactone produced by Mycobacterium ulcerans". In Biology of Mycobacterial Lipids, 271-290. Elsevier, 2022.
10.1016/b978-0-323-91948-7.00008-7
Fevereiro, João; Fraga, Alexandra G.; Pedrosa, Jorge. "The Immunology of Buruli Ulcer". 2019.

Journal article

Dominguez, Juan; Mendes, Ana I.; Pacheco, Ana R.; Peixoto, Maria J.; Pedrosa, Jorge; Fraga, Alexandra G.. "Repurposing of statins for Buruli Ulcer treatment: antimicrobial activity against Mycobacterium ulcerans". Frontiers in Microbiology 14 (2023): http://dx.doi.org/10.3389/fmicb.2023.1266261.
10.3389/fmicb.2023.1266261
Azarias Da Silva, Marne; Nioche, Pierre; Soudaramourty, Calaiselvy; Bull-Maurer, Anne; Tiouajni, Mounira; Kong, Dechuan; Zghidi-Abouzid, Ouafa; et al. "Repetitive mRNA vaccination is required to improve the quality of broad-spectrum anti–SARS-CoV-2 antibodies in the absence of CXCL13". Science Advances 9 31 (2023): http://dx.doi.org/10.1126/sciadv.adg2122.
10.1126/sciadv.adg2122
Santa Cruz, André; Mendes-Frias, Ana; Azarias-da-Silva, Marne; André, Sónia; Oliveira, Ana Isabel; Pires, Olga; Mendes, Marta; et al. "Post-acute sequelae of COVID-19 is characterized by diminished peripheral CD8+ß7 integrin+ T cells and anti-SARS-CoV-2 IgA response". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-37368-1.
10.1038/s41467-023-37368-1
Mendes, Ana Isabel; Fraga, Alexandra Gabriel; Peixoto, Maria João; Aroso, Ivo; Longatto-Filho, Adhemar; Marques, Alexandra Pinto; Pedrosa, Jorge. "Gellan gum spongy-like hydrogel-based dual antibiotic therapy for infected diabetic wounds". Bioengineering & Translational Medicine 8 3 (2023): http://dx.doi.org/10.1002/btm2.10504.
10.1002/btm2.10504
MENDES, Ana Isabel; PEIXOTO, Maria João; MARQUES, Alexandra Pinto; PEDROSA, Jorge; FRAGA, Alexandra Gabriel. "An optimized mouse model of Staphylococcus aureus infected diabetic ulcers". BMC Research Notes 15 1 (2022): http://dx.doi.org/10.1186/s13104-022-06170-5.
10.1186/s13104-022-06170-5
André, Sonia; Azarias da Silva, Marne; Picard, Morgane; Alleaume-Buteau, Aurélie; Kundura, Lucy; Cezar, Renaud; Soudaramourty, Calaiselvy; et al. "Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients". Cell Death and Disease 13 8 (2022): http://dx.doi.org/10.1038/s41419-022-05190-0.
10.1038/s41419-022-05190-0
Mendes, Ana I.; Rebelo, Rita; Aroso, Ivo; Correlo, Vitor M.; Fraga, Alexandra G.; Pedrosa, Jorge; Marques, Alexandra P.. "Development of an antibiotics delivery system for topical treatment of the neglected tropical disease Buruli ulcer". International Journal of Pharmaceutics 623 (2022): 121954. http://dx.doi.org/10.1016/j.ijpharm.2022.121954.
10.1016/j.ijpharm.2022.121954
André, Sonia; Picard, Morgane; Cezar, Renaud; Roux-Dalvai, Florence; Alleaume-Butaux, Aurélie; Soundaramourty, Calaiselvy; Cruz, André Santa; et al. "T cell apoptosis characterizes severe Covid-19 disease". Cell Death & Differentiation (2022): http://dx.doi.org/10.1038/s41418-022-00936-x.
10.1038/s41418-022-00936-x
Fevereiro, João; Fraga, Alexandra G.; Pedrosa, Jorge. "Genetics in the Host- Mycobacterium ulcerans interaction". Immunological Reviews 301 1 (2021): 222-241. http://dx.doi.org/10.1111/imr.12958.
10.1111/imr.12958
Frias, Jorge; Toubarro, Duarte; Fraga, Alexandra; Botelho, Claudia; Teixeira, José; Pedrosa, Jorge; Simões, Nelson. "Purification and Characterization of a Thrombolytic Enzyme Produced by a New Strain of Bacillus subtil". Journal of Microbiology and Biotechnology 31 2 (2021): 327-337. http://dx.doi.org/10.4014/jmb.2008.08010.
10.4014/jmb.2008.08010
Santa Cruz, André; Mendes-Frias, Ana; Oliveira, Ana Isabel; Dias, Luís; Matos, Ana Rita; Carvalho, Alexandre; Capela, Carlos; et al. "Interleukin-6 Is a Biomarker for the Development of Fatal Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia". Frontiers in Immunology 12 (2021): http://dx.doi.org/10.3389/fimmu.2021.613422.
10.3389/fimmu.2021.613422
Fevereiro, João; Fraga, Alexandra G.; Capela, Carlos; Sopoh, Ghislain E.; Dossou, Ange; Ayelo, Gilbert Adjimon; Peixoto, Maria João; et al. "Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer". Emerging Microbes & Infections 10 1 (2021): 223-225. http://dx.doi.org/10.1080/22221751.2021.1878936.
10.1080/22221751.2021.1878936
Fevereiro, João; Sajjadi, Nikta; Fraga, Alexandra G.; Teixeira, Pedro M.; Pedrosa, Jorge. "Individual and clinical variables associated with the risk of Buruli ulcer acquisition: A systematic review and meta-analysis". PLOS Neglected Tropical Diseases 14 4 (2020): e0008161. http://dx.doi.org/10.1371/journal.pntd.0008161.
10.1371/journal.pntd.0008161
Duarte, Diana; Fraga, Alexandra G.; Pedrosa, Jorge; Martel, Fátima; Vale, Nuno. "Increasing the potential of cell-penetrating peptides for cancer therapy using a new pentagonal scaffold". European Journal of Pharmacology 860 (2019): 172554. http://dx.doi.org/10.1016/j.ejphar.2019.172554.
10.1016/j.ejphar.2019.172554
Oliveira, Hugo; Mendes, Ana; Fraga, Alexandra G.; Ferreira, Alice; Pimenta, Andreia I.; Mil-Homens, Dalila; Fialho, Arsénio M.; Pedrosa, Jorge; Azeredo, Joana. "K2 Capsule Depolymerase Is Highly Stable, Is Refractory to Resistance, and Protects Larvae and Mice from Acinetobacter baumannii Sepsis". Applied and Environmental Microbiology 85 17 (2019): http://dx.doi.org/10.1128/aem.00934-19.
10.1128/aem.00934-19
Fraga, Alexandra G.; Trigo, Gabriela; Murthy, Ramya K.; Akhtar, Shamim; Hebbur, Madhavi; Pacheco, Ana Rita; Dominguez, Juan; et al. "Antimicrobial activity of Mycobacteriophage D29 Lysin B during Mycobacterium ulcerans infection". PLOS Neglected Tropical Diseases 13 8 (2019): e0007113. http://dx.doi.org/10.1371/journal.pntd.0007113.
10.1371/journal.pntd.0007113
Miranda, Margarida S; Rodrigues, Marcia T; Domingues, Rui M A; Torrado, Egidio; Reis, Rui L; Pedrosa, Jorge; Gomes, Manuela E. "Exploring inhalable polymeric dry powders for anti-tuberculosis drug delivery.". Materials science & engineering. C, Materials for biological applications 93 (2018): 1090-1103. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=MEDLINE&KeyUT=MEDLINE:30274040&KeyUID=MEDLINE:30274040.
10.1016/j.msec.2018.09.004
Miranda, Margarida S.; Rodrigues, Marcia T.; Domingues, Rui M. A.; Costa, Rui R.; Paz, Elvira; Rodriguez-Abreu, Carlos; Freitas, Paulo; et al. "Development of Inhalable Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in Microparticulate System for Antituberculosis Drug Delivery". Advanced Healthcare Materials 7 15 (2018): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000440983700007&KeyUID=WOS:000440983700007.
10.1002/adhm.201800124
Fraga, Alexandra G.; Barbosa, Ana Margarida; Ferreira, Catarina M.; Fevereiro, João; Pedrosa, Jorge; Torrado, Egídio. "Immune-evasion Strategies of Mycobacteria and Their Implications for the Protective Immune Response". Current Issues in Molecular Biology (2018): 169-198. http://dx.doi.org/10.21775/cimb.025.169.
10.21775/cimb.025.169
Vale, N.; Correia, A.; Silva, S.; Figueiredo, P.; Mäkilä, E.; Salonen, J.; Hirvonen, J.; et al. "Preparation and biological evaluation of ethionamide-mesoporous silicon nanoparticles against Mycobacterium tuberculosis". Bioorganic and Medicinal Chemistry Letters 27 3 (2017): 403-405. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008457887&partnerID=MN8TOARS.
10.1016/j.bmcl.2016.12.060
De Trizio, A.; Srisuk, P.; Costa, R.R.; Fraga, A.G.; Modena, T.; Genta, I.; Dorati, R.; et al. "Natural based eumelanin nanoparticles functionalization and preliminary evaluation as carrier for gentamicin". Reactive and Functional Polymers 114 (2017): 38-48. http://www.scopus.com/inward/record.url?eid=2-s2.0-85015691972&partnerID=MN8TOARS.
10.1016/j.reactfunctpolym.2017.03.004
Sousa, Nuno; Palha, Joana Almeida; Pedrosa, Jorge; Leão, Cecília. "Building an innovative Medical School in Portugal: the experience of the University of Minho". Fundacion Educacion Medica 20 1 (2017): 5-9. http://hdl.handle.net/1822/50269.
Published
Capela, C.; Dossou, A.D.; Silva-Gomes, R.; Sopoh, G.E.; Makoutode, M.; Menino, J.F.; Fraga, A.G.; et al. "Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer". PLoS Neglected Tropical Diseases 10 4 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84964851240&partnerID=MN8TOARS.
10.1371/journal.pntd.0004671
Silva, J.P.; Gonçalves, C.; Costa, C.; Sousa, J.; Silva-Gomes, R.; Castro, A.G.; Pedrosa, J.; Appelberg, R.; Gama, F.M.. "Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment". Journal of Controlled Release 235 (2016): 112-124. http://www.scopus.com/inward/record.url?eid=2-s2.0-84973165158&partnerID=MN8TOARS.
10.1016/j.jconrel.2016.05.064
Cruz, A.; Ludovico, P.; Torrado, E.; Gama, J.B.; Sousa, J.; Gaifem, J.; Appelberg, R.; et al. "IL-17A promotes intracellular growth of Mycobacterium by inhibiting apoptosis of infected macrophages". Frontiers in Immunology 6 SEP (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84946550863&partnerID=MN8TOARS.
10.3389/fimmu.2015.00498
Capela, C.; Sopoh, G.E.; Houezo, J.G.; Fiodessihoué, R.; Dossou, A.D.; Costa, P.; Fraga, A.G.; et al. "Clinical Epidemiology of Buruli Ulcer from Benin (2005-2013): Effect of Time-Delay to Diagnosis on Clinical Forms and Severe Phenotypes". PLoS Neglected Tropical Diseases 9 9 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84943174778&partnerID=MN8TOARS.
10.1371/journal.pntd.0004005
Barroso, T.R.G.; Martins, V.C.; Cardoso, F.; Cardoso, S.; Pedrosa, J.; Correia-Neves, M.; Rivas, J.; Freitas, P.P.. "Detecting antibody-labeled BCG MNPs using a magnetoresistive biosensor and magnetic labeling technique". Journal of Nano Research 34 (2015): 49-60. http://www.scopus.com/inward/record.url?eid=2-s2.0-84951007612&partnerID=MN8TOARS.
10.4028/www.scientific.net/JNanoR.34.49
Cruz, A.; Torrado, E.; Carmona, J.; Fraga, A.G.; Costa, P.; Rodrigues, F.; Appelberg, R.; et al. "BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4⁺IL-17⁺TNF⁺IL-2⁺ T cells". Vaccine 33 1 (2015): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-84919360521&partnerID=MN8TOARS.
10.1016/j.vaccine.2014.11.013
Carvalho, A.; Costa, P.; Triunfante, V.; Branca, F.; Rodrigues, F.; Santos, C.L.; Correia-Neves, M.; et al. "Analysis of a local HIV-1 epidemic in portugal highlights established transmission of Non-B and Non-G subtypes". Journal of Clinical Microbiology 53 5 (2015): 1506-1514. http://www.scopus.com/inward/record.url?eid=2-s2.0-84928032043&partnerID=MN8TOARS.
10.1128/JCM.03611-14
Silva-Gomes, R.; Marcq, E.; Trigo, G.; Gonçalves, C.M.; Longatto-Filho, A.; Castro, A.G.; Pedrosa, J.; Fraga, A.G.. "Spontaneous Healing of Mycobacterium ulcerans Lesions in the Guinea Pig Model". PLoS Neglected Tropical Diseases 9 12 (2015): http://www.scopus.com/inward/record.url?eid=2-s2.0-84953274374&partnerID=MN8TOARS.
10.1371/journal.pntd.0004265
Gama, J.B.; Ohlmeier, S.; Martins, T.G.; Fraga, A.G.; Sampaio-Marques, B.; Carvalho, M.A.; Proença, F.; et al. "Proteomic analysis of the action of the mycobacterium ulcerans toxin Mycolactone: Targeting host cells cytoskeleton and collagen". PLoS Neglected Tropical Diseases 8 8 (2014): 1-14. http://www.scopus.com/inward/record.url?eid=2-s2.0-84939784611&partnerID=MN8TOARS.
10.1371/journal.pntd.0003066
Teixeira-Coelho, M.; Guedes, J.; Ferreirinha, P.; Howes, A.; Pedrosa, J.; Rodrigues, F.; Lai, W.S.; et al. "Differential post-transcriptional regulation of IL-10 by TLR2 and TLR4-activated macrophages". European Journal of Immunology 44 3 (2014): 856-866. http://www.scopus.com/inward/record.url?eid=2-s2.0-84896030127&partnerID=MN8TOARS.
10.1002/eji.201343734
Trigo, G.; Martins, T.G.; Fraga, A.G.; Longatto-Filho, A.; Castro, A.G.; Azeredo, J.; Pedrosa, J.. "Phage Therapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model". PLoS Neglected Tropical Diseases 7 4 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84876876365&partnerID=MN8TOARS.
10.1371/journal.pntd.0002183
Menino, J.F.; Saraiva, M.; Gomes-Rezende, J.; Sturme, M.; Pedrosa, J.; Castro, A.G.; Ludovico, P.; Goldman, G.H.; Rodrigues, F.. "P. brasiliensis Virulence Is Affected by SconC, the Negative Regulator of Inorganic Sulfur Assimilation". PLoS ONE 8 9 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84884191896&partnerID=MN8TOARS.
10.1371/journal.pone.0074725
Martins, M.; Rodrigues, A.; Pedrosa, J.M.; Carvalho, M.J.; Cabrita, A.; Oliveira, R.. "Update on the challenging role of biofilms in peritoneal dialysis". Biofouling 29 8 (2013): 1015-1027. http://www.scopus.com/inward/record.url?eid=2-s2.0-84883650134&partnerID=MN8TOARS.
10.1080/08927014.2013.824566
Menino, J.F.; Saraiva, M.; Gomes-Alves, A.G.; Lobo-Silva, D.; Sturme, M.; Gomes-Rezende, J.; Saraiva, A.L.; et al. "TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival". PLoS Neglected Tropical Diseases 7 7 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84880846173&partnerID=MN8TOARS.
10.1371/journal.pntd.0002317
Carmona, J.; Cruz, A.; Moreira-Teixeira, L.; Sousa, C.; Sousa, J.; Osorio, N.S.; Saraiva, A.L.; et al. "Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response". PLoS ONE 8 6 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84879468975&partnerID=MN8TOARS.
10.1371/journal.pone.0067277
Osório, N.S.; Rodrigues, F.; Gagneux, S.; Pedrosa, J.; Pinto-Carbó, M.; Castro, A.G.; Young, D.; Comas, I.; Saraiva, M.. "Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic- and nonantibiotic-related pressure". Molecular Biology and Evolution 30 6 (2013): 1326-1336. http://www.scopus.com/inward/record.url?eid=2-s2.0-84877727980&partnerID=MN8TOARS.
10.1093/molbev/mst038
Martins, T.G.; Trigo, G.; Fraga, A.G.; Gama, J.B.; Longatto-Filho, A.; Saraiva, M.; Silva, M.T.; Castro, A.G.; Pedrosa, J.. "Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulcerans Infection". PLoS Neglected Tropical Diseases 6 11 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84870754979&partnerID=MN8TOARS.
10.1371/journal.pntd.0001925
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Intellectual property

Patent

Silva, João Pedro; Appelberg, Rui; Pedrosa, Jorge; Castro, Gil; Gama, Miguel. 2017. "Antimicrobial peptide-loaded hyaluronic acid-based formulations for the treatment of infectious diseases".
Pending

Activities

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2018 - Current	Innate Immunity in Mycobacterium ulcerans infection: implications in therapeutics Supervisor of Juan Pablo Dominguez Enriquez	Health Sciences (PhD)
2017 - 2023	Genética da resistência do Hospedeiro a Mycobacterium ulcerans, ponte entre modelos clínicos e celulares/animais. Supervisor of João Pedro Gouveia Fevereiro	Medicine (PhD)
2018 - 2022	An Innovative Therapeutic Approach for Infected Chronic Wounds Supervisor of Ana Isabel da Silva Mendes	Health Sciences (PhD)
2012 - 2016	Immunogenetic determinants of susceptibility/resistance to Mycobacterium ulcerans infection: a population based study - Benin biological bank on Buruli ulcer Supervisor of Carlos Alberto Pereira Capela	Medicine (PhD)
2009 - 2014	Molecular cytopathogenesis induced by the mycobacterium ulcerans toxin, mycolactone Supervisor of José Bernardo da Costa Gama	Health Sciences (PhD)
2009 - 2014	Determining the immune response in human immunodefficiency virus infection : HIV -1 diversity as tool for epidemic monitoring Supervisor of Alexandre Manuel Câmara de Carvalho	Medicine (PhD)
2009 - 2013	Influence of the variability of mycobacterium tuberculosis strains on the host immune response Co-supervisor of Jenny Andrea Carmona Valencia	Health Sciences (PhD)
2007 - 2012	Host-pathogen interactions in mycobacterium ulcerans infections. Implications for the development of new control strategies Supervisor of Teresa Maria Gonçalves Martins	Health Sciences (PhD)
2007 - 2012	Impact of mycobacterial recognition by toll like receptors in the regulation of IL-10 and T helper type of responses Co-supervisor of Maria Rosinda Teixeira Coelho	Health Sciences (PhD)
2005 - 2010	Understanding Burulli Ulcer: Elucidation of the Cellular and Molecular Mechanisms Underlying Infection with Mycobacterium ulcerans Supervisor of Alexandra Gabriel Fraga	Health Sciences (PhD)
2008 - 2009	Modulation of the immune response to mycobacteria: implications on protection and pathology Supervisor of Daniela Ramos Pereira	Health Sciences (Master)
2008 - 2009	Characterization of the in vitro cytokine response of phagocytes to Mycobacteria Supervisor of Carole Sousa	Health Sciences (Master)
2005 - 2008	Estudo da resposta fagocitária a isolados clínicos de Candida albicans Co-supervisor of Marlene Santos	. (Master)
2004 - 2007	Estudo da Resposta Imune Celular À Infecção Experimental por Microbactérias de Diferentes Virulências: Desenvolvimento de Novas Estratégias Preventivas Supervisor of Egídio Manuel Pires Torrado	Health Sciences (PhD)
2004 - 2007	Understanding Bcg Vaccination:implications for the Design of New Preventive Strategies Against Mycrobacteriosis Co-supervisor of Andrea Patrícia Ribeiro da Cruz	Health Sciences (PhD)
2002 - 2003	Estudo do papel das proteínas secretadas por Candida albicans e Mycobacterium avium em infecções experimentais, e o seu potencial como antigénios alvo em estudos de imunoprotecção Supervisor of Egídio Torrado	. (Master)