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Ana Isabel Madaleno Sebastião completed the Integrated Master's degree in Pharmaceutical Sciences in the Faculty of Pharmacy of the University of Coimbra (FFUC) in 2020. At the moment, she is a PhD student in the doctoral program PhD in Pharmaceutical Sciences at FFUC, which is funded by Fundação para a Ciência e Tecnologia (FCT). Ana has published seven articles in journals and participated in three projects prior to her PhD project. Ana's work is in the area of medical and health sciences, with a focus on pharmacology and pharmacy.
Identification

Personal identification

Full name
Ana Isabel Madaleno Sebastião
Gender
Female

Citation names

  • Sebastião, Ana Isabel
  • Sebastião, AI

Author identifiers

Ciência ID
E611-D60B-6087
ORCID iD
0000-0002-1687-2968

Email addresses

  • anaisabelsebastiao@gmail.com (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Advanced (C1) Upper intermediate (B2) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2021/12/07 - 2025
Ongoing
 PhD in Pharmaceutical Sciences (Doutoramento)
University of Coimbra, Faculty of Pharmacy, Portugal
"Development of a prophylactic dendritic cell-based vaccine: the only way to halt triple-negative breast cancer?" (THESIS/DISSERTATION)
2023 - 2024
Concluded
 VII Modular Training in Laboratory Animal Science (Outros)
Major in Laboratory animal science
University of Coimbra Centre for Neuroscience and Cell Biology, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal
Function A, B, SS
2023/07/13
Concluded
 Curso Teórico de 20h de Ciências de Animais de Laboratório (Outros)
Sociedade Portuguesa de Ciências em Animais de Laboratório, Portugal
2023
Concluded
 Flow Cytometry and Cell Sorting - From Basic Concepts to Artificial Intelligence applied to Data Analysis (Outros)
Universidade de Coimbra, Portugal
2021/02/25 - 2021/05/31
Concluded
 English for Academic Purposes II (Outros)
University of Coimbra, Faculty of Arts and Humanities , Portugal
 17
2020/12/02 - 2021/02/25
Concluded
 Portuguese Academic Writing (Outros)
University of Coimbra, Faculty of Arts and Humanities , Portugal
 16
2015/09 - 2020/09
Concluded
 Pharmaceutical Sciences (Mestrado integrado)
University of Coimbra, Faculty of Pharmacy, Portugal
"NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify" (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2021/01/22 - 2021/11/16 Researcher (Research) University of Coimbra, Faculty of Pharmacy, Portugal
University of Coimbra Centre for Neuroscience and Cell Biology, Portugal
2020/01/06 - 2020/03/31 Research Trainee (Research) University of Coimbra, Faculty of Pharmacy, Portugal
University of Coimbra Centre for Neuroscience and Cell Biology, Portugal
2019/04 - 2019/08 Research Trainee (Research) University of Coimbra, Faculty of Pharmacy, Portugal
University of Coimbra Centre for Neuroscience and Cell Biology, Portugal
2018/07 - 2018/09 Research Trainee (Research) Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Others

Category
Host institution 		Employer
2021/12/07 - Current PhD Student University of Coimbra, Faculty of Pharmacy, Portugal
2020/05/04 - 2020/08/31 Curricular Internship - Pharmacist Farmácia de Celas, Portugal
2019/08 - 2019/09 Summer Internship - Pharmacist Farmácia Salutis, Portugal
Projects

Grant

Designation Funders
2021/12/01 - Current Development of a prophylactic dendritic cell-based vaccine: the only way to halt triple-negative breast cancer?
DOI: 10.54499/2021.04586.BD
PhD Student Fellow
University of Coimbra, Faculty of Pharmacy, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
2021/03 - 2021/12 Vesículas extracelulares de Giardia lamblia na imunomodulação de células do hospedeiro: potencial aplicação terapêutica das EVs de Giardia na inflamação intestinal
PTDC/SAU-PAR/31506/2017
Other
University of Coimbra, Faculty of Pharmacy, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2021/01/22 - 2021/11/16 TECNICOV : Development of rapid tests for antibody anti-SARS-CoV-2 monitorization in serum and saliva
POCI-01-02B7-FEDER-069745
Research Fellow
University of Coimbra, Faculty of Pharmacy, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Concluded
2020/01/06 - 2020/03/31 Development of a new medical device for prevention of allergic contact dermatitis
PD/BDE/142926/2018
Research Trainee
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing
Outputs

Publications

Conference poster
  1. Sebastião, AI; Oliveira, Filomena; Simões, Gonçalo; Mateus, Daniela; Gomes, Célia; Neves, Bruno; Carrascal, Mylène A.; Cruz, Maria Teresa. Corresponding author: Cruz, Maria Teresa. "Dendritic cells loaded with cancer-testis antigens to halt triple-negative breast cancer". Paper presented in III ASPIC-ASEICA International Meeting, 2023.
  2. Faria, Clarissa Perez; Ferreira, Bárbara; Ágata Lourenço; Mateus, Daniela; Sebastião, Ana Isabel; Neves, Bruno; Cruz, Maria Teresa; Maria do Céu Rodrigues de Sousa. Corresponding author: Maria do Céu Rodrigues de Sousa. "Extracellular Vesicles of Giardia lamblia modulate host cell innate immunity: new avenues for the exploitation of novel therapies". Paper presented in 33rd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID), 2023.
  3. Sebastião, AI; Oliveira, Filomena; Simões, Gonçalo; Mateus, Daniela; Gomes, Célia; Neves, Bruno; Carrascal, Mylène A.; Cruz, Maria Teresa. Corresponding author: Cruz, Maria Teresa. "Dendritic Cell-Loading Vaccine With Cancer-Testis Antigens To Halt Triple-Negative Breast Cancer Cell". Paper presented in XLVIII SPI Annual Meeting 2023, 2023.
  4. Mateus, Daniela; Sebastião, Ana Isabel; Carrascal, Mylène; Cortes, Luisa; Carmo, Anália; Matos, Ana Miguel; Maria Goreti Ferreira Sales; Cruz, Maria Teresa. Corresponding author: Cruz, Maria Teresa. ""SARS-CoV-2, Dendritic Cells, and Immunity: the connected dots"". Paper presented in BEB day, 2022.
Journal article
  1. Jesus, Ana; Correia-da-Silva, Marta; Confraria, Catarina; Silva, Sílvia; Brites, Gonçalo; Sebastião, AI; Carrascal, Mylène; et al. "Persulfated Ascorbic Acid Glycoside as a Safe and Stable Derivative of Ascorbic Acid for Skin Care Application". Molecules 29 19 (2024): 4604. http://dx.doi.org/10.3390/molecules29194604.
    10.3390/molecules29194604
  2. Brites, Gonçalo S.; Ferreira, Isabel; Sebastião, AI; Sousa, Cátia; Silva, Ana; Carrascal, Mylene; Oliveira, Rui C.; et al. "Blocking the adverse outcome pathway of skin sensitization through a N-acetyl cysteine and lysine-loaded hydrogel". Journal of Pharmaceutical Analysis (2024): 101071. http://dx.doi.org/10.1016/j.jpha.2024.101071.
    10.1016/j.jpha.2024.101071
  3. Jesus, Sandra; Panão Costa, João; Colaço, Mariana; Lebre, Filipa; Mateus, Daniela; Sebastião, AI; Cruz, Maria T.; Alfaro-Moreno, Ernesto; Borges, Olga. "Exploring the immunomodulatory properties of glucan particles in human primary cells". International Journal of Pharmaceutics 655 (2024): 123996. http://dx.doi.org/10.1016/j.ijpharm.2024.123996.
    10.1016/j.ijpharm.2024.123996
  4. Mateus, Daniela; Sebastião, AI; Frasco, Manuela F.; Carrascal, Mylène A.; Falcão, Amílcar; Gomes, Célia M.; Neves, Bruno; Sales, Maria G. F.; Cruz, Maria T.. Corresponding author: Cruz, Maria T.. "Artificial Dendritic Cells: A New Era of Promising Antitumor Immunotherapy". Small (2023): http://dx.doi.org/10.1002/smll.202303940.
    10.1002/smll.202303940
  5. Jesus, Ana; Sebastião, AI; Brites, Gonçalo; Correia-da-Silva, Marta; Cidade, Honorina; Cruz, Maria T.; Sousa, Emília; Almeida, Isabel F.. "A Hydrophilic Sulfated Resveratrol Derivative for Topical Application: Sensitization and Anti-Allergic Potential". Molecules 28 7 (2023): 3158. http://dx.doi.org/10.3390/molecules28073158.
    10.3390/molecules28073158
  6. Sebastião, AI; Daniela Mateus; Mylène A. Carrascal; Cátia Sousa; Luísa Cortes; Martin F. Bachmann; Anália do Carmo; et al. Corresponding author: Maria Teresa Cruz. "CuMV VLPs Containing the RBM from SARS-CoV-2 Spike Protein Drive Dendritic Cell Activation and Th1 Polarization". Pharmaceutics (2023): https://doi.org/10.3390/pharmaceutics15030825.
    10.3390/pharmaceutics15030825
  7. Correia, Bárbara P.; Sousa, Mariana P.; Sousa, Cristina E. A.; Mateus, Daniela; Sebastião, AI; Cruz, Maria Teresa; Matos, Ana Miguel; Pereira, Ana Cláudia; Moreira, Felismina T. C.. "Development of colorimetric cellulose-based test-strip for the rapid detection of antibodies against SARS-CoV2 virus". Cellulose (2022): http://dx.doi.org/10.1007/s10570-022-04808-y.
    10.1007/s10570-022-04808-y
  8. Cardoso, Ana R.; Alves, João Frederico; Frasco, Manuela F.; Piloto, Ana Margarida; Serrano, Verónica; Mateus, Daniela; Sebastião, AI; et al. "An ultra-sensitive electrochemical biosensor using the spike protein for capturing antibodies against SARS-CoV-2 in point-of-care". Materials Today Bio (2022): 100354. http://dx.doi.org/10.1016/j.mtbio.2022.100354.
    Open access • Published • 10.1016/j.mtbio.2022.100354
  9. Conte, Fernanda; Pereira, Ana Catarina; Brites, Gonçalo Sousa; Ferreira, Isabel; Silva, Ana Cristina; Sebastião, AI; Matos, Patrícia; et al. "Exploring the antioxidant, anti-inflammatory and antiallergic potential of Brazilian propolis in monocytes". Journal of Pharmacy and Pharmacology (2022): https://doi.org/10.1016/j.phyplu.2022.100231.
    Published
  10. Mateus, Daniela; Sebastião, Ana Isabel; Carrascal, Mylène A.; Carmo, Anália do; Matos, Ana Miguel; Cruz, Maria Teresa. "Crosstalk between estrogen, dendritic cells, and SARS-CoV-2 infection". Reviews in Medical Virology (2021): http://dx.doi.org/10.1002/rmv.2290.
    Published • 10.1002/rmv.2290
  11. Brites, Gonçalo Sousa; Ferreira, Isabel; Sebastião, Ana Isabel; Silva, Ana; Carrascal, Mylene; Neves, Bruno Miguel; Cruz, Maria T.. "Allergic contact dermatitis: From pathophysiology to development of new preventive strategies". Pharmacological Research 162 (2020): 105282. http://dx.doi.org/10.1016/j.phrs.2020.105282.
    Published • 10.1016/j.phrs.2020.105282
  12. Sebastião, Ana Isabel; Ferreira, Isabel; Brites, Gonçalo; Silva, Ana; Neves, Bruno Miguel; Teresa Cruz, Maria. "NLRP3 Inflammasome and Allergic Contact Dermatitis: A Connection to Demystify". Pharmaceutics 12 9 (2020): 867. http://dx.doi.org/10.3390/pharmaceutics12090867.
    Open access • Published • 10.3390/pharmaceutics12090867
Activities

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2020/02/05 - 2020/02/07 SPF Meeting: L Reunião Sociedade Portuguesa de Farmacologia XXXVIII Reunião Farmacologia Clínica XIX Reunião Toxicologia (2020/02/05 - 2020/02/07)
Meeting (Other)
 Sociedade Portuguesa de Farmacologia, Portugal
2019/03/07 - 2019/03/08 XII Congresso Científico NEF/AAC: "Doenças (Re)Emergentes - Um Problema de Saúde Pública" (2019/03/07 - 2019/03/08)
Congress (Member of the Organising Committee)
 Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023/10/28 - Current 1st IMMUNO-ONCOLOGY SPO-SPI JOINT MEETING
Meeting
 1st IMMUNO-ONCOLOGY SPO-SPI JOINT MEETING
Sociedade Portuguesa de Imunologia, Portugal
2022/09/30 - Current European Researchers' Night
Other
 European Researchers' Night
Universidade de Coimbra, Portugal
2023/10/26 - 2023/10/27 III ASPIC-ASEICA International Meeting
Meeting
 III ASPIC-ASEICA International Meeting
Associação Portuguesa de Investigação em Cancro, Portugal
2023/10/26 - 2023/10/27 XLVIII SPI Annual Meeting 2023
Meeting
 XLVIII SPI Annual Meeting 2023
Sociedade Portuguesa de Imunologia, Portugal
2021/09/24 - 2021/09/24 Immune System - a friend or a foe?
Other
 European Researchers' Night
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/02/05 - 2020/02/07 SPF Meeting: L Reunião Sociedade Portuguesa de Farmacologia XXXVIII Reunião Farmacologia Clínica XIX Reunião Toxicologia
Meeting
 SPF Meeting
Sociedade Portuguesa de Farmacologia, Portugal
2020/01/10 - 2020/01/10 Introduction to Laboratory Safety and Introduction to BSL-2
University of Coimbra - Centre for Neurociences and Cell Biology, Portugal
2017/11/24 - 2017/11/25 XII Congresso Científico AEFFUP - "Farmacêutico Com Valor"
Congress
 XII Congresso Científico AEFFUP
Associação de Estudantes da Faculdade de Farmácia da Universidade do Porto, Portugal

Association member

Society Organization name Role
2022 - Current GreenLabs@CIBB GreenKeeper
2021 - Current EIT Health
2019/06 - 2020/09 Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra Coordinator of Formation Department
2018/06 - 2019/05 Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra Collaborator of Formation Department
2017/06 - 2018/05 Núcleo de Estudantes de Farmácia da Associação Académica de Coimbra Collaborator of Student Support Office

Mentoring / Tutoring

Topic Student name
2024/01/15 - 2024/05/31 Tutor of lab rotation in Master in Biomedical Research 7 students
Distinctions

Award

2023 ImmunoTools Award
2020 3% Best Students Award
University of Coimbra, Faculty of Pharmacy, Portugal
2018 3% Best Students Award
University of Coimbra, Faculty of Pharmacy, Portugal