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Carolina Rocha Pereira. Concluded her PhD in Pharmaceutical Sciences, Specialty Pharmacology and Pharmacotherapy, on January 10th 2013, from the University of Porto, Faculty of Pharmacy. Degree in Pharmaceutical Sciences on July 28th 2005, from the University Institute of Health Sciences (IUCS-CESPU). She is Assistant Professor at IUCS-CESPU. She has published 18 papers in specialized journals and several abstracts in international scientific journals. She is co-author of 3 book chapters. She has made several scientific communications (oral and poster) at national and international congresses, conferences and meetings. She was part of research projects, particularly in the pedagogical field, some of which were at an international level (TOX-OER; OEMONOM). She supervised/co-supervised 4 Master's dissertations. She has received 2 awards. She participated in several Master's juries and was responsible for the evaluation of several Master's and PhD seminars, as well as Master's dissertations. She collaborates as a reviewer in several international journals with peer review, with a good impact index, in the pharmacological and toxicological fields. She works in the area(s) of Medical and Health Sciences with an emphasis on Pharmacology and Toxicology. She has extensive expertise in university teaching, being responsible for curricular units on Pharmacology, Therapeutics, Pharmacotherapy and Pathophysiology. In its Science Vitae curriculum, the most frequent terms in the context of scientific, technological and artistic-cultural production are: Health Sciences; Medical and health sciences; membrane transporters; efflux pumps; multidrug resistance; toxicokinetics.
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Identification

Personal identification

Full name
Carolina Rocha Pereira

Citation names

  • Rocha-Pereira, Carolina

Author identifiers

Ciência ID
E710-8F24-EE9B
ORCID iD
0000-0002-1296-8858
Researcher Id
S-5428-2016
Scopus Author Id
14421779400

Email addresses

  • carolina.pereira@iucs.cespu.pt (Professional)

Telephones

Telephone
  • 224157100 Ext.: 185 (Professional)

Addresses

  • Associate Laboratory i4HB - Institute for Health and Bioeconomy, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Porto, Portugal (Professional)
  • UCIBIO - Applied Molecular Biosciences Unit, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313, Porto, Porto, Portugal (Professional)
  • 1H-TOXRUN - One Health Toxicology Research Unit, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116, Gandra, Porto, Portugal (Professional)
  • University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 , Gandra, Porto, Portugal (Professional)

Websites

  • orcid.org/0000-0002-1296-8858 (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
French Elementary (A2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Spanish; Castilian Upper intermediate (B2) Upper intermediate (B2) Intermediate (B1) Upper intermediate (B2)
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Education
Degree Classification
2016/05/02 - 2019/03/31
Concluded
 Postdoctoral Project NORTE-01-0145-FEDER-000024 New Technologies for three Health Challenges of Modern Societies: Diabetes, Drug Abuse and Kidney Diseases (DESignBIOtecHealth) (Postgraduate Certificate)
Major in Toxicology
Universidade do Porto Faculdade de Farmácia, Portugal
2013/01/10
Concluded
 Pharmaceutical Sciences - Pharmacology and Pharmacotherapy (Doctor of Philosophy)
Universidade do Porto Faculdade de Farmácia, Portugal
"Functional and morphological characterization of vascular presynaptic adenosine receptors in spontaneously hypertensive rats." (THESIS/DISSERTATION)
 Approved with distinction
2006/01/06 - 2007/12/18
Concluded
 Specialist in Pharmaceutical Technology - Biopharmacy (Postgraduate Certificate)
Universidade do Porto Faculdade de Farmácia, Portugal
 17
2007/01/29 - 2007/02/16
Concluded
 Researcher-Coordinator - Course of Science in Laboratory Animals (prepared according to the FELASA recommendations, Category C - Researcher-coordinator for the practice of animal experimentation) (Postgraduate Certificate)
Major in Animal Science
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2005/07/28
Concluded
 Pharmaceutical Sciences (Doctor)
Instituto Universitário de Ciências da Saúde, Portugal
"N/A" (THESIS/DISSERTATION)
 Fifteen values
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2023 - Current Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2013 - Current Adjunct Teacher (Polytechnic Teacher) Instituto Politécnico de Saude do Norte - Campus de Penafiel, Portugal
2020 - 2022 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
Instituto Universitário de Ciências da Saúde, Portugal
2012/09/01 - 2016/04/22 Invited Assistant Professor (University Teacher) Instituto Universitário de Ciências da Saúde, Portugal
2013/09 - 2016/01 Invited Adjunct Teacher (Polytechnic Teacher) Universidade Católica Portuguesa Faculdade de Ciências da Saúde e Enfermagem Porto, Portugal
2009/10/01 - 2013/07/31 Invited Assistant (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2016/05/02 - 2019/03/31 Invited Researcher (Master classes) Universidade do Porto Faculdade de Farmácia, Portugal
2006/02/01 - 2006/03/30 Free participation in the research project "Stability of pesticides in treated water for human consumption, after chloration" IAREN - Instituto Água Região Norte, Portugal
Projects

Grant

Designation Funders
2016/05 - 2019/03 New Technologies for three Health Challenges of Modern Societies: Diabetes, Drug Abuse and Kidney Diseases (DESignBIOtecHealth). Task 3: Exploratory ADME & Safety NORTE-01-0145-FEDER-000024
HEALTH_RL2_PHD_GEB_01
 ICETA - Instituto de Ciências e Tecnologias Agrárias e Agro-Alimentares da Universidade do Porto
2006/11 - 2011/03 Functional and morphological characterization of presynaptic adenosine receptors in spontaneously hypertensive rats (SHR)
SFRH /BD / 32161 / 2006
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Institute for Health and Bioeconomy
LA/P/0140/2020
10.54499/LA/P/0140/2020
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal

Universidade NOVA de Lisboa, Portugal

INESC Microsistemas e Nanotecnologias, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2020/01/01 - 2023/12/31 Applied Molecular Biosciences Unit
UIDB/04378/2020
10.54499/UIDB/04378/2020
Universidade NOVA de Lisboa, Portugal

Unidade de Ciências Biomoleculares Aplicadas, Portugal

Rede de Química e Tecnologia Laboratório Associado para a Química Verde, Portugal

Associação para a Inovação e Desenvolvimento da FCT, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade do Porto, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2020 - 2023 OEMONOM Open access Educational Materials On Naturally Occurring Molecules - sources, biological activity and use
2020-1-CZ01-KA203-078218
Post-doc
Universidade do Porto Faculdade de Farmácia, Portugal
 Comissão Europeia e co-financiado pelo Programa Erasmus+ da União Europeia
Ongoing
2018/07/02 - 2021/09/30 Antimicrobials from the sea: innovative agent models to reverse multidrug resistance
PTDC/SAU-PUB/28736/2017
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal

Instituto de Biologia Molecular e Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2015 - 2018 TOX-OER Learning Toxicology through Open Educational Resources
2015-1-ES01- KA203-015957
Post-doc
Universidade do Porto Faculdade de Farmácia, Portugal
 Comissão Europeia e co-financiado pelo Programa Erasmus+ da União Europeia
Concluded
2008/01/01 - 2011/03/31 New therapeutic approaches in cancer: rational design and synthesis of new adenosine A3 receptor ligands
PTDC/QUI/70359/2006
Universidade de Coimbra Unidade de Investigação e Desenvolvimento Química-Física Molecular, Portugal

Instituto Politécnico do Porto Instituto Superior de Engenharia do Porto, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. "Antidepressores". In Toxicologia Forense, 329-355. Lisboa, Portugal: Lidel - Edições Técnicas LDA, 2015.
    Published
  2. "Image analysis in microscopy An historical perspective". In Image Analysis in Life Science, 1-18. Kerala: Research Signpost, 2009.
    Published
  3. "Quantitative image analysis of immunohistochemistry specimens using SACAIA method". In Image Analysis in Life Science, 19-33. Kerala: Research Signpost, 2009.
    Published
Journal article
  1. Silva, Bárbara; Soares, Jorge; Rocha-Pereira, Carolina; Mladenka, Premysl; Remião, Fernando. "Khat, a Cultural Chewing Drug: A Toxicokinetic and Toxicodynamic Summary". Toxins 14 2 (2022): 71. http://dx.doi.org/10.3390/toxins14020071.
    Published • 10.3390/toxins14020071
  2. Silva, Vera; Gil-Martins, Eva; Silva, Bárbara; Rocha-Pereira, Carolina; Sousa, Maria Emília; Remião, Fernando; Silva, Renata. "Xanthones as P-glycoprotein modulators and their impact on drug bioavailability". Expert Opinion on Drug Metabolism & Toxicology 17 4 (2021): 441-482. http://dx.doi.org/10.1080/17425255.2021.1861247.
    Published • 10.1080/17425255.2021.1861247
  3. Carolina Rocha-Pereira; Carolina I. Ghanem; Renata Silva; Alfredo G. Casanova; Margarida Duarte-Araújo; Salomé Gonçalves-Monteiro; Emília Sousa; Maria de Lourdes Bastos; Fernando Remião. "P-glycoprotein activation by 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) in rat distal ileum: ex vivo and in vivo studies". Toxicology and Applied Pharmacology 386 (2020): 114832-114832. https://doi.org/10.1016/j.taap.2019.114832.
    10.1016/j.taap.2019.114832
  4. Eva Martins; Vera Silva; Agostinho Lemos; Andreia Palmeira; Ploenthip Puthongking; Emília Sousa; Carolina Rocha-Pereira; et al. "Newly Synthesized Oxygenated Xanthones as Potential P-Glycoprotein Activators: In Vitro, Ex Vivo, and In Silico Studies". Molecules 24 4 (2019): 707-707. https://doi.org/10.3390%2Fmolecules24040707.
    10.3390/molecules24040707
  5. Rocha-Pereira, Carolina. "Histological and Toxicological Evaluation, in Rat, of a P-glycoprotein Inducer and Activator: the 1-(propan-2- ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5)". EXCLI J 18 (2019): 697-722.
    Published
  6. C.R. Pereira; C.I. Ghanem; R. Silva; M.D. Araújo; S.G. Monteiro; A.G. Casanova; S. Chhann; et al. "The effects of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5) on P-glycoprotein activity and expression in the rat instestinal mucosa: An ex vivo and in vivo approach". Toxicology Letters 295 (2018): S268-S268. https://doi.org/10.1016%2Fj.toxlet.2018.07.027.
    10.1016/j.toxlet.2018.07.027
  7. C. Rocha-Pereira; J. Soares; A.G. Casanova; H. Carmo; F. Carvalho; M.D.L. Bastos; F. Remião. "TOX-OER MOOC: The liver as target organ". Toxicology Letters 295 (2018): S258-S259. https://doi.org/10.1016%2Fj.toxlet.2018.06.1049.
    10.1016/j.toxlet.2018.06.1049
  8. Mariline Gameiro; Renata Silva; Carolina Rocha-Pereira; Helena Carmo; Félix Carvalho; Maria Bastos; Fernando Remião. "Cellular Models and In Vitro Assays for the Screening of modulators of P-gp, MRP1 and BCRP". Molecules 22 4 (2017): 600-600. https://doi.org/10.3390%2Fmolecules22040600.
    10.3390/molecules22040600
  9. A. Ferreira; F. Ponte; R. Silva; C.R. Pereira; E. Sousa; M. Pinto; M. Bastos; F. Remião. "1-(Propan-2-ylamino)-4-propoxy-9h-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein activator: In vivo study and method development and validation for biological samples quantification". Toxicology Letters 258 (2016): S184-S185. https://doi.org/10.1016%2Fj.toxlet.2016.06.1681.
    10.1016/j.toxlet.2016.06.1681
  10. Ana Filipa Ferreira; Filipa Ponte; Renata Silva; Carolina Rocha-Pereira; Emília Sousa; Madalena Pinto; Maria de Lourdes Bastos; Fernando Remião. "Quantification of 1-(propan-2-ylamino)-4-propoxy-9H-thioxanthen-9-one (TX5), a newly synthetized P-glycoprotein inducer/activator, in biological samples: method development and validation". Biomedical Chromatography 31 2 (2016): e3802-e3802. https://doi.org/10.1002%2Fbmc.3802.
    10.1002/bmc.3802
  11. Ricardo Jorge Dinis-Oliveira; Mariana Soares; Carolina Rocha-Pereira; Félix Carvalho. "Human and experimental toxicology of orellanine". Human & Experimental Toxicology 35 9 (2016): 1016-1029. https://doi.org/10.1177%2F0960327115613845.
    10.1177/0960327115613845
  12. C. Rocha-Pereira; J.B. Sousa; M.S. Vieira-Rocha; P. Fresco; J. Gonçalves; C. Diniz. "Differential inhibition of noradrenaline release mediated by inhibitory A1-adenosine receptors in the mesenteric vein and artery from normotensive and hypertensive rats". Neurochemistry International 62 4 (2013): 399-405. https://doi.org/10.1016%2Fj.neuint.2013.02.010.
    10.1016/j.neuint.2013.02.010
  13. Carolina Rocha-Pereira; Silvia Magdalena Arribas; Paula Fresco; Maria Carmen González; Jorge Gonçalves; Carmen Diniz. "Impaired Inhibitory Function of Presynaptic A1-Adenosine Receptors in SHR Mesenteric Arteries". Journal of Pharmacological Sciences 122 2 (2013): 59-70. https://doi.org/10.1254%2Fjphs.12266fp.
    10.1254/jphs.12266fp
  14. C Rocha-Pereira; P Fresco; SM Arribas; MC González; MV Conde; J Gonçalves; C Diniz. "PRESYNAPTIC ADENOSINE RECEPTORS IN SUPERIOR MESENTERIC ARTERY FROM SPONTANEOUSLY HYPERTENSIVE RATS: A FUNCTIONAL AND MORPHOLOGICAL STUDY: PP.29.169". Journal of Hypertension 28 (2010): e499-e500. https://doi.org/10.1097%2F01.hjh.0000379707.68136.a5.
    10.1097/01.hjh.0000379707.68136.a5
  15. Paula Fresco; Jorge M.A. Oliveira; Filip Kunc; Ana Sofia Soares; Carolina Rocha-Pereira; Jorge Gonçalves; Carmen Diniz. "A2A adenosine-receptor-mediated facilitation of noradrenaline release in rat tail artery involves protein kinase C activation and ß¿ subunits formed after a2-adrenoceptor activation". Neurochemistry International 51 1 (2007): 47-56. https://doi.org/10.1016%2Fj.neuint.2007.03.009.
    10.1016/j.neuint.2007.03.009
  16. Carmen Diniz; Sandra Leal; Karen Logan; Carolina Rocha-Pereira; Ana Sofia Soares; Eduardo Rocha; Jorge Gonçalves; Paula Fresco. "Immunohistochemical localization of angiotensin II receptor types 1 and 2 in the mesenteric artery from spontaneously hypertensive rats". Microscopy Research and Technique 70 8 (2007): 677-681. https://doi.org/10.1002%2Fjemt.20453.
    10.1002/jemt.20453
  17. Sandra Leal; Carmen Diniz; Carlos Sá; Jorge Gonçalves; Ana Sofia Soares; Carolina Rocha-Pereira; Paula Fresco. "Semiautomated computer-assisted image analysis to quantify 3,3'-diaminobenzidine tetrahydrochloride-immunostained small tissues". Analytical Biochemistry 357 1 (2006): 137-143. https://doi.org/10.1016%2Fj.ab.2006.07.017.
    10.1016/j.ab.2006.07.017
Thesis / Dissertation
  1. Maria Carolina Rocha e Pinho Pereira Meireles Amorim. "Functional and morphological characterization of vascular presynaptic adenosine receptors in spontaneously hypertensive rats.". PhD, 2013. https://hdl.handle.net/10216/73436.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022 - 2023 In vivo evaluation of NPS: focus on Cathinones
Supervisor
 Biomedical Sciences Degree (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2021 - 2022 Spermatogenesis protection by P-Glycoprotein modulation
Co-supervisor
 Mestrado em Toxicologia Analítica, Clínica e Forense (Master)
2020 - 2021 Xenobióticos Tóxicos para a Espermatogénese
Co-supervisor
 Mestrado em Toxicologia Analítica Clínica e Forense (Other)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 - 2021 Assessment of potential neuroprotective effects of new xanthones derivatives
Supervisor
 Estágio de Investigação em Ciências Biomédicas (Degree)
Instituto Universitário de Ciências da Saúde, Portugal
2017 - 2018/11 Newly synthetized xanthones as potential P-glycoprotein and BCRP modulators at the intestinal barrier: in vitro and ex vivo studies
Supervisor
 Toxicologia Analítica Clínica e Forense (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2017 - 2018 Validation of an analytical method for toxicokinetic study of 6-(2-aminopropyl)benzofuran (6-APB) in rats
Co-supervisor
 Mestrado em Ciências Forenses (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Universidade do Porto Faculdade de Medicina, Portugal
2015 - 2016 In vivo studies on the toxic effects of orellanine: search for efficient antidotes
Co-supervisor
 Mestrado em Toxicologia Analítica, Clínica e Forense (Master)
Universidade do Porto Faculdade de Farmácia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021 Crosstalk between autophagic intermediaries in neurotoxicity induced by Synthetic Cannabinoids
(Thesis) Arguer
 Catarina Pereira Teixeira (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 Role of autophagy in the neurotoxicity induced by synthetic cannabinoids
(Thesis) Arguer
 Rosa Patrícia Ferreira Pinto (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2020 Interindividual variability in ABCB1 expression in human Sertoli cells
(Thesis) Arguer
 Samuel Madureira Silva (Master)
Universidade do Porto Faculdade de Farmácia, Portugal
2019 Cancro da mama: Análise do tratamento, das reações adversas e dos procedimentos adotados pelos profissionais de saúde
(Thesis) Arguer
 Tânia Dias Lourenço (Other)
Universidade do Porto Faculdade de Farmácia, Portugal

Consulting

Activity description Institution / Organization
2018 - 2018 Avaliação prévia a tese de doutoramento, requisito essencial da Universidade de Salamanca para a obtenção do doutoramento europeu. Assim, como investigadora doutorada e integrada numa Universidade estrangeira, foi-me solicitada a declaração de qualidade e mérito científicos da tese do Alfredo Casanova, favorável à atribuição do grau de doutor internacional. Universidade do Porto Faculdade de Farmácia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2021 - 2021 Toxicology and Applied Pharmacology
2020 - 2020 Toxicology and Applied Pharmacology
2019 - 2019 Journal of Chemistry
2018 - 2018 Brazilian Journal of Pharmaceutical Sciences

Other jury / evaluation

Activity description Institution / Organization
2019 - 2020 New brain targeting approaches based on PEGylated PLGA nanoparticles for drug delivery and treatment of neurodegenerative disorders Universidade do Porto Faculdade de Farmácia, Portugal
2019 - 2020 DME/Tox studies for new pharmacological agents
2014 - 2015 Importance of Fluoride Salts in Forensic Toxicology Universidade do Porto Faculdade de Farmácia, Portugal
Distinctions

Other distinction

2009 Best Poster presentation
1999 Student with distinction, 12th school year