Dominique Moreira Fernandes (E811-246E-94D9)

Curriculum Vitae

Dominique Moreira Fernandes

Dominique Fernandes is a Postdoctoral Researcher at the Synapse Biology group at the Center for Neuroscience and Cell Biology, University of Coimbra, Portugal. She graduated in Biochemistry in 2009, (BSc, University of Porto) and in Cell and Molecular Biology, with a specialization in Neurobiology in 2011 (MSc, University of Coimbra). She concluded her PhD in Experimental Biology and Biomedicine in 2018, under the supervision of Prof. Ana Luísa Carvalho and Dr. Sandra Santos. During her PhD, carried at the University of Coimbra and the Johns Hopkins University in Baltimore, USA, she studied the role of two cell-adhesion proteins, CASPR1 & CASPR2, in underlying key molecular mechanisms that regulate synaptic function in the context of homeostatic synaptic plasticity. She is now interested in exploring how neuronal homeostasis acts to maintain network stability in the brain, and in understanding whether these processes are likely targets for dysfunction in several neuropsychiatric disorders. She is also investigating the mechanisms elicited by CASPR2 autoantibodies that drive pathogenesis in autoimmune synaptic encephalitis. Dominique has published 3 papers (Q1, h-index 2, 78 citations in Scopus, 127 citations in GoogleScholar) and has three more manuscripts in preparation. She is actively participating in 5 different collaborative projects. She has presented her work in over 15 national and international conferences, having won awards for best presentation and multiple travel grants. Dominique often teaches classes, has officially supervised 5 MSc and BSc students, and over 15 students on laboratory rotations. She has participated in grant evaluation committees, contributed to manuscript peer-reviewing and has collaborated in the preparation of several grant proposals, having already submitted as PI. She has extensive expertise in biochemistry and cellular and molecular biology techniques, including preparation of primary cultures of dissociated neurons, cloning and lentiviral production; widefield microscopy and data analysis; cell and acute slice electrophysiology; as well as animal surgery techniques and animal handling.

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Identification

Personal identification

Full name: Dominique Moreira Fernandes

Citation names

Fernandes, D
Fernandes, Dominique

Author identifiers

Ciência ID: E811-246E-94D9
ORCID iD: 0000-0001-5114-6227

Email addresses

dom.mfernandes@gmail.com (Professional)
dominique.fernandes@u-bordeaux.fr (Professional)

Addresses

Equipe Laurent GROC, IINS-CNRS UMR 5297, Centre Broca Nouvelle Aquitaine, 146 Rue Léo Saignat, 33076, Bordeaux, Nouvelle Aquitaine, France (Professional)

Websites

https://www.iins.u-bordeaux.fr/GROC (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Neurosciences
Natural sciences - Biological Sciences - Cell Biology
Natural sciences - Biological Sciences - Molecular Biology
Natural sciences - Biological Sciences - Biochemistry
Natural sciences - Biological Sciences - Developmental Biology

Languages

Language	Speaking	Reading	Writing	Listening
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Intermediate (B1)	Upper intermediate (B2)	Intermediate (B1)	Intermediate (B1)
German	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2011/09 - 2018/06 Concluded	Biologia Experimental e Biomedicina (Doutoramento) Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal "Role of CASPR1 & CASPR2 in the regulation of glutamatergic transmission and synaptic plasticity - Implication for disease pathogenesis" (THESIS/DISSERTATION)	Approved with praise and distinction by unanimity
2014 - 2014 Concluded	Course of Sciences in Laboratory Animals (Curso médio) Centro de Neurociências e Biologia Celular , Portugal
2009/09 - 2011/09 Concluded	Biologia Celular e Molecular (Mestrado integrado) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal "Post-transcriptional mechanisms of regulation of AMPA receptors: Regulation of GluA1 expression by Caspr1" (THESIS/DISSERTATION)	18
2006/09 - 2009/09 Concluded	Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal "Purinergic, cholinergic and tachykinergic signalling in the myenteric plexus of the ileum of control and capsaicin-treated mice - a study by confocal microscopy" (THESIS/DISSERTATION)	15

Affiliation

Science

	Category Host institution	Employer
2022/02/21 - Current	Postdoc (Research)	Centre National de la Recherche Scientifique, France
	Institut Interdisciplinaire de Neurosciences, France
2018/09 - 2021/12	Contracted Researcher (Research)	CNC.IBILI, Portugal

2008/12 - 2009/12	Research Trainee (Research)	Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Others

	Category Host institution	Employer
2011/09 - 2018/06	PhD student	CNC.IBILI, Portugal

2014/09 - 2015/06	Visiting PhD Student	Johns Hopkins University Zanvyl Krieger Mind/Brain Institute, United States

2009/09 - 2011/09	MSc Student	CNC.IBILI, Portugal

Projects

Grant

	Designation	Funders
2018/09 - 2021/12	Understanding the pathogenesis in CASPR2-antibody autoimmune synaptic encephalitis PTDC/MED-NEU/29452/2017 Researcher CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/06 - 2018/03	A role for Contactin-associated proteins 1 and 2 in experience-dependent plasticity PTDC/NEU-NMC/4888/2014 Research Fellow CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2015/12 - 2016/05	Schizophrenia as a disruption of developmental homeostatic plasticity: a role for stargazin 23151 Research Fellow CNC.IBILI, Portugal	Brain and Behavior Research Foundation Concluded
2013/07 - 2015/11	Effects of the orexigenic peptide ghrelin on glutamatergic synaptic transmission PTDC/NEU-NMC/1098/2012 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2013/07 - 2015/09	A Novel Model for Schizophrenia: Defects in Stargazin-Mediated Homeostatic Plasticity. PTDC/NEU-NMC/0750/2012 Researcher CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia
2011/04 - 2013/06	Regulation of the stability of the messenger RNA for the GluR1 subunit of glutamate receptors PTDC/BIA-BCM/113738/2009 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2020 - Current	CIBB Strategic Plan UIDB/04539/2020 Researcher CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia
2018 - 2019/12	CNC.IBILI Strategic Plan UID/NEU/04539/2019 Researcher CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia
2015/01/01 - 2017/12/31	CNC. IBILI UID/NEU/04539/2013 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia
2013 - 2014/12	Strategic Project - LA 1 - 2013-2014 PEst-C/SAU/LA0001/2013 Researcher Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Fundação para a Ciência e a Tecnologia

Outputs

Publications

Conference abstract	Lino, Miguel; Rondão, Tiago; Banerjee, A; Aires, I; Rodrigues, M; Fernandes, Dominique; Freitas, J; et al. "Extracellular Vesicles Secreted by Mononuclear Cells from Umbilical Cord Blood Induce Neuroprotection and Angiogenesis and Attenuate Microglia Reactivity in a Mouse Model of Brain Ischemia". Paper presented in European Journal of Clinical Investigation, 2022. Published Fernandes, D; Santos, Sandra; Whitt, Jessica L; Coutinho, Ester; Leite, M. Isabel; Buckley, Camilla; Lee, Hey-Kyoung; Carvalho, Ana Luisa. "Autism-associated CASPR2 regulates synaptic AMPA receptors in the context of homeostatic synaptic plasticity". Paper presented in Joint Biennial Meeting of the International Society of Neurochemistry and the European Society for Neurochemistry (ISN-ESN), Paris, 2017. Published Silva, Isabel; Duarte-Araújo, Margarida; Fernandes, Dominique; Ferreirinha, Fátima; Vieira, Cátia; Correia-de-Sá, Paulo. "Tripartite myenteric synapse: crosstalk between excitatory A2A, NK1 and M3 receptors". Paper presented in Purines 2010, 2010. Published
Conference poster	Serrenho, Débora; Fernandes, Dominique; Vasconcelos, Ana; Santos, Sandra; Cortes, Luisa; Coutinho, Ester; Carvalho, Ana Luisa. "Human anti-CASPR2 autoantibodies impact synaptic transmission and neuronal excitability (to be presented)". Paper presented in 8th European Synapse Meeting, 2022. Carvalhais, Lia; Carvalho, Mário; Selleri, D; Fernandes, Dominique; Schmidt, J; Milosevic, I; Carvalho, Ana Luisa; Pinheiro, Paulo. "New insights into the roles of SNAP-29 in neuronal and synaptic functions (to be presented)". Paper presented in 8th European Synapse Meeting, 2022. Fernandes, Dominique; Vasconcelos, Ana; Santos, Sandra; Coutinho, Ester; Whitt, Jessica L; Lee, Hey-Kyoung; Carvalho, Ana Luísa. "CASPR2 autoantibodies elicit concentration-dependent perturbations in the regulation of AMPA receptor trafficking and synaptic plasticity". Paper presented in 13th FENS Forum of Neuroscience, 2022. Oliveira, Ana Rafaela; Cammarata, G; Cardoso, AM; Seabra, C; Guedes, J; Cardoso, AL; Fernandes, Dominique; et al. "Autism associated CASPR2 auto-immune antibodies modify the developmental trajectory and network activity in human brain organoids". Paper presented in 13th FENS Forum of Neuroscience, 2022. Vasconcelos, Ana; Fernandes, Dominique; Santos, Sandra Manuela Domingues dos; Coutinho, Ester; Carvalho, Ana Luisa. "Concentration-dependent effects elicited by CASPR2 autoantibodies in the regulation of AMPA receptor trafficking and synaptic plasticity". Paper presented in Encephalitis Society 2021, 2021. Vasconcelos, Ana; Fernandes, Dominique; Santos, Sandra Manuela Domingues dos; Coutinho, Ester; Whitt, Jessica L; Lee, Hey-Kyoung; Carvalho, Ana Luisa. "CASPR2 autoantibodies elicit concentration-dependent perturbations in the regulation of AMPA receptor trafficking and synaptic plasticity.". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021. Oliveira, Ana Rafaela; Seabra, Catarina; Guedes, Joana; Cammarata, Giuseppe; Cardoso, Ana Maria; Fernandes, Dominique; Coutinho, Ester; et al. "Uncovering the neurodevelopmental consequences of anti-CASPR2 antibody exposure in 3D brain organoids". Paper presented in XVII Meeting of the Portuguese Society for Neuroscience, 2021. Fernandes, Dominique; Vasconcelos, Ana; Santos, Sandra Manuela Domingues dos; Coutinho, Ester; Whitt, Jessica L; Lee, Hey-Kyoung; Carvalho, Ana Luisa. "CASPR2 autoantibodies elicit concentration-dependent perturbations in the regulation of AMPA receptor trafficking and synaptic plasticity". Paper presented in Currents Trends in Biomedicine: The Synaptic Dimension of Brain Disorders, 2021. Oliveira, AR; Seabra, CM; Guedes, JR; Cammarata, G; Fernandes, D; Coutinho, E; Carvalho, AL; Ferreira, L.; Peça, J. "Uncovering the role of immune response in ASD: Neurodevelopmental consequences of anti-CASPR2 antibodies exposure in 3D brain organoids". Paper presented in EMBL Symposium - Organoids: Modelling Organ Development and Disease in 3D Culture, 2020. Fernandes, Dominique; Vasconcelos, Ana M.; Santos, Sandra; Coutinho, Ester; Whitt, Jessica L; Beltrão, Nuno; Rondão, Tiago; et al. "Disrupted AMPA receptor function and synaptic plasticity upon genetic- or antibody-mediated loss of autism-related CASPR2". Paper presented in CIBB Annual Meeting, 2019. Fernandes, Dominique; Vasconcelos, Ana M.; Santos, Sandra; Coutinho, Ester; Whitt, Jessica L; Beltrão, Nuno; Rondão, Tiago; et al. "CASPR2 autoantibodies disrupt AMPA receptor function". Paper presented in Encephalitis Conference 2019, 2019. Fernandes, Dominique; Santos, Sandra; Coutinho, Ester; Whitt, Jessica L; Rondão, Tiago; Leite, M. Isabel; Buckley, Camilla; Lee, Hey-Kyoung; Carvalho, Ana Luísa. "Disrupted AMPA receptor function and homeostatic synaptic plasticity upon genetic- or antibody-mediated loss of autism-associated CASPR2". Paper presented in 11th FENS Forum of Neuroscience, 2018. Fernandes, Dominique; Santos, Sandra; Coutinho, Ester; Whitt, Jessica L; Rondão, Tiago; Leite, M. Isabel; Buckley, Camilla; Lee, Hey-Kyoung; Carvalho, Ana Luísa. "Disrupted AMPA receptor function and homeostatic synaptic plasticity upon genetic- or antibody-mediated loss of autism-associated CASPR2". Paper presented in 8th Meeting of the European Molecular and Cellular Cognition Society, 2018. Fernandes, Dominique; Santos, Sandra; Whitt, Jessica L; Coutinho, Ester; Leite, M. Isabel; Buckley, Camilla; Lee, Hey-Kyoung; Carvalho, Ana Luísa. "Autism-associated Caspr2 regulates synaptic AMPA receptors in the context of homeostatic synaptic plasticity". Paper presented in Joint Biennial Meeting of the International Society of Neurochemistry and the European Society for Neurochemistry (ISN-ESN), 2017. Fernandes, Dominique; Santos, Sandra; Whitt, Jessica L; Ester Coutinho; Leite, M. Isabel; Buckley, Camilla; Lee, Hey-Kyoung; Carvalho, Ana Luísa. "Autism-associated Caspr2 regulates synaptic AMPA receptors in the context of homeostatic synaptic plasticity". Paper presented in 2017 Excitatory Synapses & Brain Function Gordon Research Conference, 2017. Fernandes, Dominique; Santos, Sandra; Whitt, Jessica L; Coutinho, Ester; Leite, M. Isabel; Buckley, Camilla; Lee, Hey-Kyoung; Carvalho, Ana Luísa. "Contactin-associated proteins 1 and 2 (Caspr1 & Caspr2) - unexpected key players in the regulation of homeostatic synaptic scaling". Paper presented in 2016 Regional meeting of the International Society for Neurochemistry – Synaptic Function and Dysfunction in Brain Diseases, 2016. Fernandes, Dominique; Santos, Sandra; Ribeiro, Luís; Ceccarelli, Anna; Carvalho, Ana Luísa. "An interplay between Contactin-associated protein 1 and the RNA-binding protein ZBP1 in the regulation of homeostatic synaptic scaling". Paper presented in 2016 Regional meeting of the International Society for Neurochemistry – Synaptic Function and Dysfunction in Brain Diseases, 2016. Fernandes, Dominique; Santos, Sandra; Whitt, Jessica L; Coutinho, Ester; Leite, M. Isabel; Buckley, Camilla; Lee, Hey-Kyoung; Carvalho, Ana Luísa. "Homeostatic scaling of synaptic AMPA receptors: the unexpected role of Contactin-associated proteins 1 and 2 (Caspr1 & Caspr2)". Paper presented in Integrating Hebbian and Homeostatic Plasticity, 2016. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Homeostatic regulation of synaptic AMPA receptors by Caspr1 and the RNA-binding protein ZBP1". Paper presented in 5th European Synapse Meeting, 2015. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Unveiling the puzzle on homeostatic plasticity \| How Contactin-associated proteins 1 and 2 (Caspr1 & Caspr2) fit in to homeostatically regulate synaptic AMPA receptors.". Paper presented in 13th Annual Molecular and Cellular Cognition Society Meeting, 2014. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Unveiling the puzzle on homeostatic plasticity \| How Contactin-associated proteins 1 and 2 (Caspr1 & Caspr2) fit in to homeostatically regulate synaptic AMPA receptors". Paper presented in Neuroscience 2014 - Society for Neuroscience Annual Meeting, 2014. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Unveiling the puzzle on homeostatic plasticity \| How Contactin-associated proteins 1 and 2 (Caspr1 & Caspr2) fit in to homeostatically regulate synaptic AMPA receptors". Paper presented in Annual Meeting of the Greater Baltimore Chapter of Society for Neuroscience, 2014. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Contactin-associated proteins 1 & 2: novel players in the homeostatic regulation of synaptic AMPA receptors". Paper presented in 9th FENS Forum of Neuroscience, 2014. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Contactin-associated proteins 1 & 2: novel players in the homeostatic regulation of synaptic AMPA receptors". Paper presented in 2013 XI CNC Annual Meeting., 2013. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Homeostatic regulation of AMPA receptors in synaptic plasticity: a posttranscriptional interplay between Caspr1 and the RNA-binding protein ZBP1". Paper presented in RNA Society 18th Annual Meeting, 2013. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Contactin-associated proteins (Caspr1 & Caspr2): novel players in the activity-dependent regulation of synaptic AMPA receptors". Paper presented in XIII Reunião da Sociedade Portuguesa de Neurociências, 2013. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Activity-dependent post-transcriptional regulation of AMPA receptors by the Contactin associated protein 1". Paper presented in 2012 Champalimaud Neuroscience Symposium, 2012. Fernandes, Dominique; Ribeiro, Luís; Santos, Sandra; Carvalho, Ana Luísa. "Post-transcriptional regulation of the mRNA for the GluA1 subunit of glutamate receptors". Paper presented in Sinal2011 - 5th Annual Meeting on Cell Signalling, 2011. Silva, Isabel; Fernandes, Dominique; Ferreirinha, Fátima; Vieira, Cátia; Duarte-Araújo, Margarida; Correia-de-Sá, Paulo. "Crosstalk between excitatory A2A, M3 and NK1 receptors on a tripartite myenteric synapse". Paper presented in Worldpharma 2010, 2010. Silva, Isabel; Fernandes, Dominique; Ferreirinha, Fátima; Vieira, Cátia; Marques, Patrícia; Duarte-Araújo, Margarida; Correia-de-Sá, Paulo. "Synergism between NK1 and A2A, but not M3, receptors to control ACh release at a tripartite myenteric synapse". Paper presented in XVIII Congresso Nacional de Bioquímica, 2010. Silva, Isabel; Duarte-Araújo, Margarida; Fernandes, Dominique; Ferreirinha, Fátima; Vieira, Cátia; Correia-de-Sá, Paulo. "Tripartite myenteric synapse: crosstalk between excitatory A2A, M3 and NK1 receptors". Paper presented in Purines 2010, 2010.
Journal article	Ana Luisa Carvalho; Dominique Fernandes. "It takes two to tango: Concerted protein translation and degradation necessary for synaptic scaling". PLOS Biology (2021): https://doi.org/10.1371/journal.pbio.3001448. 10.1371/journal.pbio.3001448 Fernandes, Dominique; Santos, Sandra D; Coutinho, Ester; Whitt, Jessica L; Beltrão, Nuno; Rondão, Tiago; Leite, M Isabel; et al. "Disrupted AMPA Receptor Function upon Genetic- or Antibody-Mediated Loss of Autism-Associated CASPR2". Cerebral Cortex 29 12 (2019): 4919-4931. http://dx.doi.org/10.1093/cercor/bhz032. Published • 10.1093/cercor/bhz032 Fernandes, Dominique; Carvalho, Ana Luísa. "Mechanisms of homeostatic plasticity in the excitatory synapse". Journal of Neurochemistry 139 6 (2016): 973-996. http://dx.doi.org/10.1111/jnc.13687. Published • 10.1111/jnc.13687
Thesis / Dissertation	Fernandes, Dominique Moreira. "Role of Caspr1 and Caspr2 in the regulation of glutamatergic transmission and synaptic plasticity - implication for disease pathogenesis". PhD, 2018. http://hdl.handle.net/10316/80524. Fernandes, Dominique Moreira. "Post-transcriptional mechanisms of regulation of AMPA receptors : regulation of GluA1 expression by the contactin associated protein 1". Master, 2011. http://hdl.handle.net/10316/25915.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2022/07	Disrupted AMPA Receptor function upon autoantibody-mediated loss of CASPR2	13th FENS Forum of Neuroscience (Paris, France)
2022/06	Disrupted AMPA receptor traffic and synaptic plasticity upon genetic- or immune-mediated loss of autism-associated CASPR2	IINS seminar meetings (Bordeaux, France)
2022/05	Role of autism-associated CASPR2 in the regulation of glutamate AMPA receptors & synaptic plasticity	Scharfmann Lab at Cochin Institute (Paris, France)
2021/10	CASPR2 autoantibodies elicit concentration-dependent perturbations in the regulation of AMPA receptor trafficking and synaptic plasticity	Currents Trends in Biomedicine: The Synaptic Dimension of Brain Disorders (Baeza, Spain)
2019/09	Disrupted AMPA receptor function and synaptic plasticity upon genetic- or antibody-mediated loss of autism-associated CASPR2	7th European Synapse Meeting (Lausanne, Switzerland)
2019/05	Disrupted AMPA receptor function and synaptic plasticity upon genetic- or antibody-mediated loss of autism-associated CASPR2	1st Retreat of the Neuroscience & Disease Research Line of CIIB (Miranda do Corvo, Portugal)
2018/07	Disrupted AMPA receptor function and homeostatic synaptic plasticity upon genetic- or antibody-mediated loss of autism-associated CASPR2	ENCODS2018 – European Neuroscience Conference of Doctoral Students (Berlin, Germany)
2018/01	Disrupted AMPA receptor function upon genetic- or antibody-mediated loss of autism-associated CASPR2	BEB Day 2018 (Coimbra, Portugal)
2017/05	Caspr2 & Neuropsychiatric disorders: Insights into the pathogenic mechanisms of CASPR2-related mutation and autoantibodies	XV Meeting of the Portuguese Society for Neuroscience (Braga, Portugal)
2014/12	Contactin-associated proteins 1 & 2: new pieces in the puzzle of homeostatic plasticity?	2014 XII CNC Annual Meeting (Coimbra, Portugal)
2013/09	Contactin-associated proteins 1 & 2: novel players in the homeostatic regulation of synaptic AMPA receptors	2013 Champalimaud Neuroscience Symposium (Lisboa, Portugal)
2013	Contactin-associated protein 1: novel player in the activity-dependent regulation of synaptic AMPA receptors	XIII Reunião da Sociedade Portuguesa de Neurociências (Luso, Portugal)
2012/05	Caspr1 post-transcriptionally regulates the GluA1 subunit of AMPA glutamate receptors through activation of the Src signaling pathway	Sinal 2012 - 6th national meeting on cell signaling Instituto de Investigação em Ciências da Vida e da Saúde (Braga, Portugal)
2010	Interaction of purinergic, tachykinergic and muscarinic receptors on a tripartite synapse	IJUP 2010 – Investigação Jovem na Universidade do Porto Universidade do Porto (Porto, Portugal)
2009	Differential distribution and functional characterization of adenosine A1, A2A, A2B and A3 receptors in the rat myenteric plexus	XL Reunião Annual da Sociedade Portuguese de Farmacologia, XXVIII Reunião de Farmacologia Clínica e IX Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Porto, Portugal)
2009	Physiological interactions of excitatory A2A, M3 and NK1 receptors expressed in a tripartite myenteric synapse	XL Reunião Annual da Sociedade Portuguese de Farmacologia, XXVIII Reunião de Farmacologia Clínica e IX Reunião de Toxicologia Sociedade Portuguesa de Farmacologia (Porto, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2019/09 - 2020/12	Exploring the pathogenic mechanisms elicited by antibody-mediated loss of CASPR2 in autoimmune synaptic encephalitis Supervisor	Biologia Celular e Molecular (Master) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2020/02 - 2020/06	Dissecting the roles of SNAP29 in neuronal polarized trafficking and development Co-supervisor	Biologia (Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019/02 - 2019/07	Effect of Autoantibodies against CASPR2 from patients with autoimmune encephalitis in AMPA receptor function Co-supervisor	Biologia (Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2017/02 - 2017/07	Pathogenic mechanisms of Caspr2 autoantibodies from anti-Caspr2 autoimmune synaptic encephalitis Co-supervisor	Bioquímica (Degree) Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015/09 - 2015/12	Homeostatic regulation of AMPA Receptors: the role of ZBP1 in regulating GluA1 Co-supervisor	Biotecnologia (Degree) Università degli Studi del Sannio, Italy

Event organisation

	Event name Type of event (Role)	Institution / Organization
2013/12 - 2013/12	XI CNC Annual Meeting (2013/12 - 2013/12) Meeting (Co-organisor)	Centro de Neurociências e Biologia Celular , Portugal
2012/06 - 2012/06	1st BEB Symposium: Science Dreams, Challenges Arise (2012/06 - 2012/06) Symposium (Co-organisor)	Centro de Neurociências e Biologia Celular , Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2018/03 - 2018/03	Brain Awareness Week - Selfie Science: informal sharing of research in a public outreach video Other	Brain Awareness Week
2018/03 - 2018/03	World Sleep Day - contribution to the design of a comic strip on the importance of sleep Other	Brain Awareness Week

Association member

	Society Organization name	Role
2018 - Current	European Molecular and Cellular Cognition Society (EMCCS)
2009 - Current	Sociedade Portuguesa de Neurociências (SPN)
2016 - 2018	International Society for Neurochemistry (ISN)
2014 - 2016	Society for Neurosciences (SfN)

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2021/11 - 2021/11	Cellular and Molecular Neurobiology (02001298). Invited teacher. Molecular mechanisms of learning and memory. 3 hours.	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2021/10 - 2021/10	Advanced Course on Cell and Molecular Neurobiology. Teaching seminar: Role of AMPA receptor trafficking and function in synaptic plasticity and dysregulation in disease. 2 hours	Neurociências (Doutoramento)	Universidade de Lisboa Faculdade de Medicina, Portugal
2021/02 - 2021/07	MTBM - Métodos e Técnicas em Biologia Molecular (01001011). Invited teacher	Biologia (Licenciatura)	Universidade de Coimbra, Portugal
2021/03 - 2021/03	Advanced Course on Synapse Structure and Function. Lecture: Disrupted synaptic transmission and plasticity upon genetic or antibody-mediated disruption of Caspr2.	Biologia Experimental e Biomedicina (Doutoramento)	Universidade de Coimbra Instituto de Investigação Interdisciplinar, Portugal
2020/11 - 2020/11	Neurobiology (14241065). Teaching seminar: Role of AMPA receptor trafficking and function in synaptic plasticity and dysregulation in disease. 2 hours	Ciências Biomédicas (Licenciatura)	Universidade do Algarve, Portugal
2020/10 - 2020/10	Advanced Course on Cell and Molecular Neurobiology. Teaching seminar: Role of AMPA receptor trafficking and function in synaptic plasticity and dysregulation in disease. 2 hours	Neurociências (Doutoramento)	Universidade de Lisboa Faculdade de Medicina, Portugal
2020/02 - 2020/07	MTBM - Métodos e Técnicas em Biologia Molecular (01001011). Invited teacher	Biologia (Licenciatura)	Universidade de Coimbra, Portugal
2019/12/11 - 2019/12/11	Neuronal Circuits and Behaviour (02035364). Practical session on electrophysiology data analysis. 2 hours	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2019/10 - 2019/10	Advanced Course on Cell and Molecular Neurobiology. Teaching seminar: Role of AMPA receptor trafficking and function in synaptic plasticity and dysregulation in disease. 2 hours	Neurociências (Doutoramento)	Universidade de Lisboa Faculdade de Medicina, Portugal
2019/04 - 2019/04	Advanced Course on Neuronal Circuits & Behaviour. Lecture: CASPR2 & Glutamatergic Function: Disrupted AMPA receptor function and synaptic plasticity upon genetic- or antibody-mediated loss of CASPR2.	Biologia Experimental e Biomedicina (Doutoramento)	Universidade de Coimbra, Portugal
2018/10 - 2018/10	MBCM Lab Talks - CASPR2 & Glutamatergic Function:Disrupted AMPA receptor function & synaptic plasticity upon genetic- or antibody-mediated loss of CASPR2 \| Understanding the pathogenesis of CASPR2-antibody autoimmune synaptic encephalitis	Biologia Celular e Molecular (Mestrado integrado)	Universidade de Coimbra, Portugal
2017/02 - 2017/02	Advanced Course on Synapses, Neuronal Circuits & Behaviour. Lecture: Contactin-associated proteins 1 & 2: a role in neuronal homeostasis	Biologia Experimental e Biomedicina (Doutoramento)	Universidade de Coimbra, Portugal

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2021 - 2021	Reviewer for major grant applications Evaluator	Rosetrees Trust, United Kingdom

Journal scientific committee

	Journal title (ISSN)	Publisher
2021/05 - 2021/05	eLife
2019/10 - 2019/10	Frontiers in Pharmacology (1663-9812)	Frontiers Media SA
2018/12 - 2019/05	Neuropharmacology (0028-3908)	Elsevier
2018/05 - 2018/08	iScience (2589-0042)	Elsevier
2018/05 - 2018/05	Frontiers in Molecular Neuroscience (1662-5099)	Frontiers Media SA

Mentoring / Tutoring

	Topic	Student name
2020/07 - Current	Curricular Internship - Master in Molecular and Cellular Biology of the University of Coimbra.	Project: Dissecting the roles of SNAP-29 in synaptic function and plasticity
2011 - Current	Mentoring of laboratory rotations	Mentoring of over 15 BSc/MSc students in curricular lab rotations or voluntary internships
2016/09 - 2017/09	Curricular Internship - Master in Molecular and Cellular Biology of the University of Coimbra.	Project: Exosomes-based therapy for stroke

Distinctions

Award

2019	Award for Best Presentation at the 7th European Synapse Meeting (Lausanne, Switzerland)
2018	Award for Best Poster Presentation at the 8th Meeting of the European Molecular and Cellular Cognition Society (Berlin, Germany)

Other distinction

2022	SPN Travel Award to attend: 13th FENS Forum (Paris, France) Sociedade Portuguesa de Neurociências, Portugal
2018	Registration fee waiver to attend: ENCODS2018 – European Neuroscience Conference by Doctoral Students 2018 (Berlin, Germany) IBRO, Portugal
2018	SPN Travel Award to attend: 11th FENS Forum (Berlin, Germany) Sociedade Portuguesa de Neurociências, Portugal
2017	Travel Award to attend: Gordon Research Conference on Excitatory Synapses & Brain Function (Les Diablerets, Switzerland) Hello Bio, Portugal
2017	Registration fee waiver to attend: XV Meeting of the Portuguese Society for Neuroscience (Braga, Portugal). Sociedade Portuguesa de Neurociências, Portugal
2017	Registration fee waiver to attend: Biennial Meeting of the International Society of Neurochemistry and the European Society for Neurochemistry (Paris, France). International Society of Neurochemistry, Portugal
2017	Travel Award to attend: Biennial Meeting of the International Society of Neurochemistry and the European Society for Neurochemistry. (Paris, France). International Society of Neurochemistry, Portugal
2016	Registration fee waiver to attend: 7th International Society of Neurochemistry Special Conference - Synaptic Function and Dysfunction in Brain Diseases (Coimbra, Portugal) Sociedade Portuguesa de Neurociências, Portugal
2011	PhD Fellowship Fundação para a Ciência e a Tecnologia, Portugal
2008	Fellowship for Integration in Research - BII / UMIB-ICBAS / 2008-3 Fundação para a Ciência e a Tecnologia, Portugal