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Paula Laranjeira. Completed the Doutoramento in Biociências in 2016/01/07 by Universidade de Coimbra Faculdade de Ciencias e Tecnologia and Licenciatura in Biologia in 2003 by Universidade de Coimbra. Attends the Mestrado integrado in Medicina by Universidade de Coimbra Faculdade de Medicina since 2016/09/01. Is Researcher in Centro Hospitalar e Universitário de Coimbra EPE and in Universidade de Coimbra Faculdade de Medicina. Published 28 articles in journals. Has 2 section(s) of books. Has received 5 awards and/or honors. Participates and/or participated as Researcher in 2 project(s) and Supervisor in 3 project(s). Works in the area(s) of Natural sciences with emphasis on Biological Sciences with emphasis on Immune Cell Biology. In his curriculum Ciência Vitae the most frequent terms in the context of scientific, technological and artistic-cultural output are: mesenchymal stromal/stem cells; immunosuppression; Imunologia; Hematologia; Citometria de Fluxo; Células Mesenquimais Estaminais; Hepatocellular carcinoma; Cholangiocarcinoma; Immune system; Prognosis biomarkers; Immunophenotyping.
Identification

Personal identification

Full name
Paula Laranjeira
Gender
Female

Citation names

  • Laranjeira, Paula
  • Paula Laranjeira

Author identifiers

Ciência ID
E918-65E6-11E6
ORCID iD
0000-0002-1136-6118
Researcher Id
B-3806-2014

Email addresses

  • 1979paula@gmail.com (Professional)

Addresses

  • Unidade Funcional de Citometria de Fluxo (UFCF), Centro Hospitalar e Universitário de Coimbra, Av. Bissaya Barreto, Bloco de Celas, 3000-075, Coimbra, Coimbra, Portugal (Professional)

Websites

  • https://www.chuc.min-saude.pt/ (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
Education
Degree Classification
2016/09/01 - 2024/07/31
Ongoing
Medicina (Mestrado integrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
16 out of 20
2016/01/07
Concluded
Biociências (Doutoramento)
Major in Especialidade: Biologia Celular e Molecular
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Immunomodulation by mesenchymal stromal cells: relevance to mesenchymal stromal cells-based therapies" (THESIS/DISSERTATION)
Aprovado com distinção e louvor por unanimidade
1999 - 2003
Concluded
Biologia (Licenciatura)
Universidade de Coimbra, Portugal
16 out of 20
Affiliation

Science

Category
Host institution
Employer
2018/01/01 - Current Researcher (Research) Universidade de Coimbra Faculdade de Medicina, Portugal
2016/10/01 - Current Researcher (Research) Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2020/02/03 - 2022/01/31 Contracted Researcher (Research) Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2013/11/01 - 2016/01/07 Researcher (Research) Centro do Sangue e da Transplantação de Coimbra, Instituto Português do Sa, Portugal
2002/10 - 2013/10/31 Researcher (Research) Centro de Histocompatibilidade do Centro, Portugal
2010/01/01 - 2012/07/31 Researcher (Research) Universidad de Salamanca, Spain
Instituto de Biología Molecular y Celular del Cáncer, Spain

Teaching in Higher Education

Category
Host institution
Employer
2003/09 - 2009/09 Assistant (Polytechnic Teacher) Instituto Politécnico de Castelo Branco, Portugal
Projects

Grant

Designation Funders
2021/06/01 - 2025/06/30 canSERV
Proposal number: 101058620
Researcher
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
European Comission
Ongoing
2020/01/01 - 2023/12/31 The role of immune cells in the incidence of insulin resistance
SFRH/BD/143849/2019
Supervisor
Universidade de Coimbra, Portugal
Ongoing
2020/01/01 - 2023/12/31 CD20+ T Cells as a biomarker of inflammatory status and a promising target against cardiac rejection in heart transplanted patients
SFRH/BD/145054/2019
Supervisor
Universidade de Coimbra, Portugal
Ongoing

Contract

Designation Funders
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Universidade de Coimbra, Portugal

Universidade de Coimbra Instituto de Investigação Clínica e Biomédica de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/04/19 - 2023/11/30 Papel da células imunes no metabolismo
CHUC-115-20
Ongoing
2019/07/01 - 2021/06/30 MsCellProduction: Produção de Células Estaminais Mesenquimais em conformidade com os requisitos de Boas Práticas de Fabrico
POCI-01-247-FEDER-38313
Researcher
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Ongoing
2016/10 - 2020/01 LIPIDOMICS AND IMMUNE SYSTEM EVALUATION IN HEPATOCELLULAR CARCINOMA AND CHOLANGIOCARCINOMA
Supervisor
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Concluded
2015/10 - 2019/09 MASSTRPLAN
Researcher
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
EU Framework Programme for Research and Innovation Marie Sklodowska-Curie Actions
Concluded
2010/02/05 - 2013/06/04 O papel da glicosilação de aminofosfolipido no stress oxidativo e na resposta imune: uma abordagem lipidomica.
PTDC/QUI-BIQ/104968/2008
Universidade de Aveiro, Portugal

Universidade de Aveiro Unidade de Investigação de Química Orgânica Produtos Naturais e Agroalimentares, Portugal

Instituto Português do Sangue e da Transplantação IP, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2007/01/01 - 2011/07/31 CARACTERIZAÇÃO IMUNOFENOTÍPICA, GENÓMICA E GENÉTICA DAS DIFERENTES LINHAS CELULARES HEMATOPOIÉTICAS EM SÍNDROMES MIELODISPLÁSICOS E LEUCEMIAS MIELOBLÁSTICAS AGUDAS
SFRH/BD/32097/2006
Universidade de Coimbra, Portugal

Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Laranjeira, Paula; Paiva, Artur. "Chapter 1 - Advances in pathogenesis of systemic lupus erythematosus". In Hot topics in Systemic lupus erythematosus, 1-8. Lisboa: PERMANYER, 2022.
    Published
  2. Laranjeira, Paula; Artur Paiva. "An updated approach to myelodysplastic syndromes". In Recent Advances in Hematology Research – Myelodysplastic Syndromes: From Diagnosis to Treatment, edited by Emma E. Steffensen, 457-478. New York, United States: Nova Science Publishers, Inc., 2020.
    Published
  3. Laranjeira, Paula; Ribeiro, Andreia; Mendes, Sandrine; Henriques, Ana; Luisa, M.; Paiv, Artur. "Immunophenotypic Characterization of Normal Bone Marrow Stem Cells". In Flow Cytometry - Recent Perspectives, 457-480. Rijeka, Croatia: InTech, 2012.
    Published • 10.5772/38523
Conference abstract
  1. Carmen Martín-Sierra; Laranjeira, Paula; Artur Paiva. "Evaluation of tumour infiltrating leukocytes and peripheral blood T, NK, monocytes and dendritic cells from patients with hepatocellular carcinoma and cholangiocarcinoma.". Paper presented in Pulmonol, 2018.
    Published
  2. Carmen Martín-Sierra; Laranjeira, Paula; Artur Paiva. "Evaluation of T cell-mediated antitumor immune response in liver tumors - an approach using tumor and peripheral blood samples". Paper presented in HPB, 2018.
    Published
  3. Pedrosa, Monia; Duarte, Cátia; Laranjeira, Paula Margarida dos Santos; Gomes, Joana; Ribeiro, Tania; Santos, Francisco; Antunes, Brigida; et al. "Human bone marrow-derived mesenchymal stromal cells strongly inhibit cytokine production by naive, memory and effector CD4+ and CD8+ T cells from rheumatoid arthritis patients, independently of disease activity status". Paper presented in 35th European Workshop for Rheumatology Research, Budapeste, 2015.
    Published
  4. Matarraz, Sergio; López, Antonio; Barrena, Susana; Fernandez, Carlos; Jensen, Evan; Flores, Juan; Rasillo, Ana; et al. "Bone marrow cells from myelodysplastic sydromes show altered immunophenotypic profiles which may contribute to the diagnosis and prognostic stratification of the disease: a pilot study on series of 56 patients.". Paper presented in XXIII International Symposium on Technical Innovations in Laboratory Haematology, Brighton, 2010.
    Published
  5. Sergio Matarraz; Laranjeira, Paula; Artur Paiva; Alberto Orfao. "Altered immunophenotypic profiles of CD34- bone marrow cells from myelodysplastic syndromes contribute to the diagnostic and prognostic stratification of the disease.". Paper presented in Cytometry Part B (Clinical Cytometry), 2010.
    Published
  6. Laranjeira, Paula; Artur Paiva. "Chemokine expression in peripheral blood monocytes, neutrophils and dendritic cells in multiple sclerosis.". Paper presented in Cytometry P art B (Clinical Cytometry) 2008, 2008.
    Published
  7. Laranjeira, Paula; Artur Paiva; Alberto Orfao. "Myelodysplastic syndromes: immunophenotypic features of CD34 negative bone marrow cells from different hematopoietic lineages.". Paper presented in Cytometry P art B (Clinical Cytometry), 2008.
    Published
  8. Laranjeira, Paula Margarida dos Santos; Paiva, Artur; Silva, Isabel; Henriques, Ana; Morgado, José Mário; Matos, Rosa; Almeida, Sérgio; et al. "Myelodisplastic syndromes: immunophenotypic features of CD34 negative bone marrow cells from different hematopoietic lineages.". Paper presented in Haematologica - XLIX Reunión Nacional de la AEHH y XXIII Congreso Nacional de la SETH, Pamplona, 2007.
    Published
  9. Laranjeira, Paula; Artur Paiva. "Residual leukocyte phenotyping in leukodepleted red blood cell concentrates.". Paper presented in VoxSanguinis, 2006.
    Published
  10. Santos, Paulo; Morgado, José Mário; Pratas, Rui; Figueiredo, Constança; Crespo, Inês; Laranjeira, Paula Margarida dos Santos; Freitas, Albertina; et al. "IL-1ß, IL-6, IL-12, TNF-a and TNF-ß produced by peripheral blood monocytes and subsets of dendritic cells in multidrug-resistant pulmonary tuberculosis.". Paper presented in 18th European Immunogenetics and Histocompatibility Conference, Sofia, 2004.
    Published
  11. Roncon-Albuquerque, R; Henriques-Coelho, T; Vasconcelos, M; Laranjeira, P; Nogueira, A; Teles, A; Leite-Moreira, AF. "Distinct pattern of myocardial gene expression of interleukin-6 in acute pressure and volume overload". Paper presented in ESC Congress 2004 - European Heart Journal, Munich, 2004.
    Published
  12. Santos, Paulo; Morgado, José Mário; Figueiredo, Constança; Laranjeira, Paula Margarida dos Santos; Freitas, Albertina; Paiva, Artur; Domingos, A; Regateiro, Fernando; Segorbe-Luís, A. "Cytokine production by peripheral blood monocytes and subsets of dendritic cells from MDR-TB patients". Paper presented in European Respiratory Society Annual Congress, Viena, 2003.
    Published
Conference poster
  1. Cristiana Rodrigues; Laranjeira, Paula; Pinho, A. C. O.; Isabel Silva; Sandra Silva; Margarida Coucelo; Catarina Geraldes; Artur Paiva. "CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia". Paper presented in CIMAGO FMUC, 2024.
  2. Pinho, Aryane; Barbosa, Pedro; Lazaro, André; Paula, Diogo; Campos, José Carlos; Tralhão, José; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "CD20+ T cells and Mitochondrial Respiration - insights from human studies". Paper presented in XI Jornadas de Cirurgia, Bariatric Sessions 1ª edição, 2023.
  3. Pinho, Aryane; Pedro Barbosa; Lazaro, André; Paula, Diogo; Tralhão, José; Campos, José Carlos; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "ALTA FREQUÊNCIA DE CÉLULAS T CD 20 NO TECIDO ADIPOSO OMENTAL DE INDIVÍDUOS COM OBESIDADE". Paper presented in 19 º Congresso Português de Diabetes, 2023.
  4. Barbosa, Pedro; Pinho, Aryane; Lazaro, André; Paula, Diogo; Campos, José Carlos; Tralhão, José; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "Is inflammation an underlying factor for insulin resistance development?". Paper presented in III Metabolism, Aging and Disease Meeting, 2023.
  5. Barbosa, Pedro; Pinho, Aryane; Lazaro, André; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "Phenotypic characterization of circulating and adipose tissue infiltrated CD4+ Treg cell.". Paper presented in Advancing Arkansas Lifespan Research Conference, University of Arkansas for Medical Sciences, Little Rock, Arkansas., 2023.
  6. Pinho, Aryane; Pedro Barbosa; Lazaro, André; Campos, José Carlos; Tralhão, José; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "Increased CD20+ T cell infiltration in omental adipose tissue from patients with obesity". Paper presented in IDF Congress 2022, 2022.
  7. Pedro, Barbosa; Pinho, Aryane; Lazaro André; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "Phenotypic characterization of circulating and adipose tissue infiltrated CD4+ Treg cells". Paper presented in IDF World Diabetes Congress Lisbon and Online, 2022.
  8. Barbosa, Pedro; Pinho, Aryane; Lazaro, André; Tralhão, José; Campos, José Carlos; Paiva, Artur; Laranjeira, Paula; Carvalho, Eugenia. "Characterization of circulating immune cells in subjects undergoing bariatric surgery". Paper presented in 26º Congresso Portuguesa de Obesidade, 2022.
  9. Barbosa, Pedro; Pinho, Aryane; Lazaro, André; Laranjeira, Paula; Carvalho, Eugenia. "Modelação das células T reguladoras associada ao fenótipo de insulinorresistência: estudo piloto". Paper presented in 18º Congresso Português de Diabetes, 2022.
  10. Carmen Martín-Sierra; Laranjeira, Paula; M. Rosário Domingues; Artur Paiva. "Functional and phenotypic characterization of TIL from human tumor biopsies in hepatocellular carcinoma and cholangiocarcinoma patients.". Paper presented in XVI Congresso da Sociedade Ibérica de Citometria, 2019.
  11. Carmen Martín-Sierra; Laranjeira, Paula; Artur Paiva. "Functional impairment of circulating precursors (FceRI+ monocytes) and fully differentiated myeloid dendritic cells in hepatocellular carcinoma and cholangiocarcinoma patients.". Paper presented in XVI Congresso da Sociedade Ibérica de Citometria, 2019.
  12. Carmen Martín-Sierra; Laranjeira, Paula; Artur Paiva. "Serum lipidomic profile of hepatocellular carcinoma and cholangiocarcinoma patients.". Paper presented in Redox-omic Technologies and their Application in Health and Disease – Summer School, 2018.
  13. Simone Colombo; Carmen Martín-Sierra; Laranjeira, Paula; Artur Paiva; M. Rosário Domingues. "Oxidized arachiyl aminophospholipidsdiversely modulate the inflammatory response mediated by peripheral blood monocytes & myeloid dendritic cells.". Paper presented in Redox-omic Technologies and their Application in Health and Disease – Summer School, 2018.
  14. Carmen Martín-Sierra; Laranjeira, Paula; Artur Paiva. "Evaluation of tumour infiltrating leukocytes and peripheral blood T, NK, monocytes and dendritic cells from patients with hepatocellular carcinoma and cholangiocarcinoma.". Paper presented in CIMAGO Scientific Meeting, 2018.
  15. Laranjeira, Paula; Rodrigues, Raquel; Carvalheiro, Tiago; Farinha, Margarida; Constanço, Conceição; Silva, Isabel; Inácio, Maria Jesus; et al. "Estudo da maturação eritróide normal e em síndromes mielodisplásicas com base na expressão de CD44 e CD35". Paper presented in Reunião Anual da Sociedade Portuguesa de Hematologia, 2013.
  16. Laranjeira, Paula; Ribeiro, Andreia; Mendes, Sandrine; Velada, Isabel; Leite, Cristiana; Andrade, Pedro; Santos, Francisco; et al. "Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, NK and T cells". Paper presented in XIII Congresso da Sociedade Ibérica de Citometria, 2013.
  17. Melo, Tânia; Santinha, Deolinda; Silva, Raquel Nunes da; Silva, Ana Cristina; Maciel, Elisabete; Simões, Cláudia; Horta, Sara; et al. "Expression of cytokines in monocytes and dendritic cells exposed to oxidized phosphatidylserines". Paper presented in XIII Congresso da Sociedade Ibérica de Citometria, 2013.
  18. Matarraz, Sergio; Teodosio, Cristina; Fernandez, Carlos; Aibors, M; Jara-Acevedo, María; López, Antonio; Gonzalez-Gonzalez, María; et al. "The proliferation index of specific compartments of bone marrow cells in myelodysplastic syndromes is associated with the subtypes of the disease and patient outcome". Paper presented in XXVII Congress of the International Society for Advancement of Cytometry, 2012.
  19. Matarraz, Sergio; López, Antonio; Barrena, Susana; Fernandez, Carlos; Jensen, Evan; Flores, Juan; Rasillo, Ana; et al. "Bone marrow cells from myelodysplastic syndromes show altered immunophenotypic profiles which may contribute to the diagnosis and prognostic stratification of the disease: a pilot study". Paper presented in 15th Congress of European Hematology Association, 2010.
  20. Laranjeira, Paula; Paiva, Artur; Silva, Isabel; Henriques, Ana; Morgado, José Mário; Matos, Rosa; Almeida, Sérgio; et al. "Myelodysplastic Syndromes: Immunophenotypic Features of CD34 Negative Bone Marrow Cells from Different Hematopoietic Lineages". Paper presented in ESH Conference: Myelodysplastic Syndromes, 2009.
  21. Laranjeira, Paula; Pedreiro, Susana; Morgado, José Mário; Almeida, Sérgio; Vitória, Helena; Pereira, A; Pais, Maria Luísa; Órfão, Alberto; Paiva, Artur. "Phenotypic and Functional Evaluation of T and NK Cells in Myelodysplastic Syndromes". Paper presented in ESH Conference: Myelodysplastic Syndromes, 2009.
  22. Pedreiro, Susana; Laranjeira, Paula; Morgado, José Mário; Silva, Isabel; Inácio, Maria Jesus; Matos, Rosa; Almeida, Sérgio; et al. "Estudo Fenotípico e Funcional de Células T e NK em Síndromes Mielodisplásicos". Paper presented in XI Congresso da Sociedade Ibérica de Citometria, 2009.
  23. Mateus, Natália; Morgado, José Mário; Laranjeira, Paula; Macário, Maria Carmo; Pais, Maria Luísa; Paiva, Artur. "Estudo do Reportório TCR-VB em Subpopulações de Células T de Doentes com Esclerose Múltipla". Paper presented in XI Congresso da Sociedade Ibérica de Citometria, 2009.
  24. Henriques, Ana; Rama, Luís; Matos, Rosa; Laranjeira, Paula; Morgado, José Mário; Silva, Isabel; Inácio, Maria Jesus; et al. "Expressão de TLRs e de Citocinas em Monócitos em Atletas de Alta Competição". Paper presented in XI Congresso da Sociedade Ibérica de Citometria, 2009.
  25. Henriques, Ana; Marrão, Gina; Laranjeira, Paula; Morgado, José Mário; Silva, Isabel; Inácio, Maria Jesus; Drouet, E; et al. "Alterações Fenotípicas e Funcionais das Células T e NK em Carcinoma da mama". Paper presented in XI Congresso da Sociedade Ibérica de Citometria, 2009.
  26. Laranjeira, Paula; Paiva, Artur; Silva, Isabel; Henriques, Ana; Morgado, José Mário; Matos, Rosa; Almeida, Sérgio; et al. "Myelodisplastic syndromes: immunophenotypic features of CD34 negative bone marrow cells from different hematopoietic lineages". Paper presented in 7th Euroconference on Clinical Cell Analysis, 2007.
  27. Laranjeira, Paula; Macário, Maria Carmo; Freitas, Albertina; Morgado, José Mário; Pais, Maria Luísa; Paiva, Artur. "Chemokine expression in peripheral blood monocytes, neutrophils and dendritic cells in multiple sclerosis.". Paper presented in 7th Euroconference on Clinical Cell Analysis, 2007.
  28. Laranjeira, Paula; Macário, Maria Carmo; Freitas, Albertina; Pais, Maria Luísa; Paiva, Artur. "Expressão de quimiocinas em monócitos, neutrófilos e células dendríticas do sangue periférico em esclerose múltipla". Paper presented in X Congresso da Sociedade Ibérica de Citometria, 2007.
  29. Laranjeira, Paula; Artur Paiva. "Caracterização Fenotípica dos percursores mielóides CD34+ da medula óssea normal e de Síndromes Mielodisplásicos.". Paper presented in X Congresso da Sociedade Ibérica de Citometria, 2007.
  30. Laranjeira, Paula. "Phenotypic alterarations on peripheral blood T cells from elite endurance athletes during a training season". Paper presented in X Congresso da Sociedade Ibérica de Citometria, 2007.
  31. Laranjeira, Paula. "Alterações na frequência de células dendríticas e monócitos produtores de citocinas em atletas de alta competição durante o ano de treinamento.". Paper presented in X Congresso da Sociedade Ibérica de Citometria, 2007.
  32. Laranjeira, Paula. "Alterações na expressão de receptores de citocinas nos leucócitos do sangue periférico de Esclerose Múltipla". Paper presented in X Congresso da Sociedade Ibérica de Citometria, 2007.
  33. Alves, M; Laranjeira, Paula; Guerra, N; Paiva, Artur; Pais, Maria Luísa; Neto, P. "Residual leucocyte phenotyping in leucodeplected red blood cell concentrates". Paper presented in XXIXth International Congress of the International Society of Blood Transfusion, 2006.
  34. Laranjeira, Paula. "Estudo do impacto da ressecção cirúrgica no aumento das células tumorais circulantes em doentes com cancro colorectal primário ou metastático". 2006.
  35. Laranjeira, Paula; Henriques, Ana; Silva, Isabel; Morgado, José Mário; Paiva, Artur. "Immunophenotypic features of myeloid blast cells from patients with myelodysplastic syndromes". Paper presented in 5th Euroconference & 8th Workshop on Clinical Cell Analysis, 2005.
  36. Laranjeira, Paula; Henriques, Ana; Silva, Isabel; Morgado, José Mário; Teixeira, Adriana; Regateiro, Fernando; Paiva, Artur. "Aberrações fenotípicas nos blastos da medula óssea de síndromes mielodisplásicos". Paper presented in Reunião Anual da Sociedade Portuguesa de Hematologia, 2005.
  37. Laranjeira, Paula. "IL-1ß, IL-6, TNF-a and TNF-ß produced by perypheral blood Monocytes and subsets of Dendritic Cells in multidrug-resistant pulmonary tuberculosis.". Paper presented in 18th European Immunogenetics and Histocompatibility Conference, 2004.
  38. Laranjeira, Paula. "Cytokine production by peripheral blood monocytes and subsets of dendritic cells from MDR-TB patients.". Paper presented in European Respiratory Society Annual Congress, 2003.
  39. Laranjeira, Paula. "Produção de Citocinas por Monócitos e sub-populações de Células Dendríticas de sangue periférico de doentes com Tuberculose Resistente (MDR-TB).". Paper presented in VIII Congresso da Sociedade Ibérica de Citometria, 2003.
  40. Laranjeira, Paula. "Estudo da Activação Plaquetária em Doenças Neurodegenerativas". Paper presented in VIII Congresso da Sociedade Ibérica de Citometria, 2003.
  41. Laranjeira, Paula. "Expressão de Bcl-2, Bax e Fas nas Células do Sangue Periférico, em Doenças Neurodegenerativas". Paper presented in VIII Congresso da Sociedade Ibérica de Citometria, 2003.
Journal article
  1. Aryane Cruz Oliveira Pinho; Pedro Barbosa; André Lazaro; José G. Tralhão; Maria João Pereira; Artur Paiva; Paula Laranjeira; Eugenia Carvalho. "Identification and characterization of circulating and adipose tissue infiltrated CD20+ T cells from subjects with obesity that undergo bariatric surgery". Immunology Letters (2024): https://doi.org/10.1016/j.imlet.2024.106911.
    10.1016/j.imlet.2024.106911
  2. Aryane Cruz Oliveira Pinho; Pedro Barbosa; Maria João Pereira; Artur Paiva; Eugenia Carvalho; Paula Laranjeira. "The role of CD20+ T cells: Insights in human peripheral blood". Cytometry Part B: Clinical Cytometry (2024): https://doi.org/10.1002/cyto.b.22178.
    10.1002/cyto.b.22178
  3. Rodrigues, Cristiana; Laranjeira, Paula; Pinho, Aryane; Silva, Isabel; Silva, Sandra; Coucelo, Margarida; Oliveira, Ana Catarina; et al. "CD20+ T cells in monoclonal B cell lymphocytosis and chronic lymphocytic leukemia: frequency, phenotype and association with disease progression". Frontiers in Oncology 14 (2024): http://dx.doi.org/10.3389/fonc.2024.1380648.
    10.3389/fonc.2024.1380648
  4. Pedro Barbosa; Aryane Pinho; André Lázaro; Diogo Paula; José G. Tralhão; Artur Paiva; Maria J. Pereira; Eugenia Carvalho; Paula Laranjeira. "Bariatric Surgery Induces Alterations in the Immune Profile of Peripheral Blood T Cells". Biomolecules (2024): https://doi.org/10.3390/biom14020219.
    10.3390/biom14020219
  5. Aryane Cruz Oliveira Pinho; Paula Laranjeira; Eugenia Carvalho. "Role of CD20+ T cells in cancer, autoimmunity and obesity". Journal of Endocrinology (2024): https://doi.org/10.1530/JOE-23-0242.
    10.1530/JOE-23-0242
  6. Pedro Barbosa; Aryane Pinho; André Lázaro; Daniela Rosendo-Silva; Diogo Paula; José Campos; José G. Tralhão; et al. "CD8+ Treg cells play a role in the obesity-associated insulin resistance". Life Sciences (2024): http://dx.doi.org/10.1016/j.lfs.2023.122306.
    10.1016/j.lfs.2023.122306
  7. Helena Beatriz Ferreira; Tânia Melo; Inês M. S. Guerra; Ana S. P. Moreira; Paula Laranjeira; Artur Paiva; Laura Goracci; et al. "Whole Blood and Plasma-Based Lipid Profiling Reveals Distinctive Metabolic Changes in Systemic Lupus Erythematosus and Systemic Sclerosis". Journal of Proteome Research (2023): https://doi.org/10.1021/acs.jproteome.3c00321.
    10.1021/acs.jproteome.3c00321
  8. Paula Laranjeira; Francisco dos Santos; Maria João Salvador; Irina N. Simões; Carla M. P. Cardoso; Bárbara M. Silva; Helena Henriques-Antunes; et al. "Umbilical-Cord-Derived Mesenchymal Stromal Cells Modulate 26 Out of 41 T Cell Subsets from Systemic Sclerosis Patients". Biomedicines (2023): https://doi.org/10.3390/biomedicines11051329.
    10.3390/biomedicines11051329
  9. Sílvia Martins; Natália António; Tiago Carvalheiro; Paula Laranjeira; Ricardo Rodrigues; Lino Gonçalves; Cândida Tomaz; Artur Paiva. "Reduced numbers of regulatory T cells in chronic heart failure seems not to be restored by cardiac resynchronization therapy". BMC Cardiovascular Disorders (2023): https://doi.org/10.1186/s12872-023-03109-x.
    10.1186/s12872-023-03109-x
  10. André Branco; Ana L. Tiago; Paula Laranjeira; Maria C. Carreira; João C. Milhano; Francisco dos Santos; Joaquim M. S. Cabral; et al. "Hypothermic Preservation of Adipose-Derived Mesenchymal Stromal Cells as a Viable Solution for the Storage and Distribution of Cell Therapy Products". Bioengineering (2022): https://doi.org/10.3390/bioengineering9120805.
    10.3390/bioengineering9120805
  11. Sampaio-Ribeiro, Gabriela; Ana Ruivo; Ana Silva; Ana Lúcia Santos; Rui Caetano Oliveira; Paula Laranjeira; Maria Augusta Cipriano; José Guilherme Tralhão; Artur Paiva. "Extensive Phenotypic Characterization of T Cells Infiltrating Liver Metastasis from Colorectal Cancer: A Potential Role in Precision Medicine". Cancers 14 24 (2022): 6069-6069. http://dx.doi.org/10.3390/cancers14246069.
    10.3390/cancers14246069
  12. Neves, Filipa Loureiro; Amaral, Mariana Nunes Gonçalves Afonso; Silva, Sandra Filomena Durães da; Silva, Isabel Maria Melo; Laranjeira, Paula Margarida dos Santos; Pinto, Carla Regina de Jesus; Paiva, Artur Augusto; Dias, Andrea Sofia da Silva; Coelho, Maria Leonor Almeida Carvalho Vieira. "Immunoparalysis in critically ill children". Immunology (2022): http://dx.doi.org/10.1111/imm.13595.
    10.1111/imm.13595
  13. Paula Laranjeira; Tiago Rodrigues; Ana Silva; Pedro Barbosa; Teresa Reis; Cristiana Lopes; Aryane Pinho; et al. "A single dose of COVID-19 vaccine induces a strong T cell and B cell response in healthcare professionals recovered from SARS-CoV-2 infection". Clinical and Experimental Medicine (2022): https://doi.org/10.1007/s10238-022-00801-8.
    Published • 10.1007/s10238-022-00801-8
  14. Costa Carvalho, J; Macário, MC; Batista, S; Alen Coutinho, I; Laranjeira, P; Loureiro, C; Paiva, A; Todo Bom, A. "Successful desensitization to alemtuzumab, with flow cytometric analysis of peripheral blood cells". Journal of Investigational Allergy and Clinical Immunology 32 6 (2022): http://dx.doi.org/10.18176/jiaci.0795.
    Accepted • 10.18176/jiaci.0795
  15. Paula Laranjeira; Mónia Pedrosa; Cátia Duarte; Susana Pedreiro; Brígida Antunes; Tânia Ribeiro; Francisco dos Santos; et al. "Human Bone Marrow Mesenchymal Stromal/Stem Cells Regulate the Proinflammatory Response of Monocytes and Myeloid Dendritic Cells from Patients with Rheumatoid Arthritis". Pharmaceutics (2022): https://doi.org/10.3390/pharmaceutics14020404.
    10.3390/pharmaceutics14020404
  16. Ana Silva; Sandra Silva; Isabel Silva; Susana Santos; Paula Laranjeira; Catarina Geraldes; Helena Silva; et al. "Bone marrow follicular-like T cells in monoclonal gammopathies". Cytometry Part B: Clinical Cytometry (2021): https://doi.org/10.1002/cyto.b.22029.
    10.1002/cyto.b.22029
  17. Martín-Sierra, C.; Martins, R.; Coucelo, M.; Abrantes, A. M.; Oliveira, R. C.; Tralhão, J. G.; Botelho, M. F.; et al. "Elevated soluble TNFa levels and upregulated TNFa mRNA expression in purified peripheral blood monocyte subsets associated with high-grade hepatocellular carcinoma". Journal of Inflammation 17 1 (2020): http://dx.doi.org/10.1186/s12950-020-00243-7.
    Published • 10.1186/s12950-020-00243-7
  18. Martín-Sierra, Carmen; Colombo, Simone; Martins, Ricardo; Laranjeira, Paula; Melo, Tânia; Abrantes, Ana Margarida; Oliveira, Rui Caetano; et al. "Tumor Resection Induces Alterations on Serum Phospholipidome of Liver Cancer Patients". Lipids (2020): http://dx.doi.org/10.1002/lipd.12221.
    Published • 10.1002/lipd.12221
  19. Martín-Sierra, C.; Martins, R.; Laranjeira, P.; Coucelo, M.; Abrantes, A.M.; Oliveira, R.C.; Tralhão, J.G.; et al. "Functional and Phenotypic Characterization of Tumor-Infiltrating Leukocyte Subsets and Their Contribution to the Pathogenesis of Hepatocellular Carcinoma and Cholangiocarcinoma". Translational Oncology 12 11 (2019): 1468-1479. http://dx.doi.org/10.1016/j.tranon.2019.07.019.
    Published • 10.1016/j.tranon.2019.07.019
  20. Mónia Pedrosa; Joana Gomes; Paula Laranjeira; Cátia Duarte; Susana Pedreiro; Brígida Antunes; Tânia Ribeiro; et al. "Immunomodulatory effect of human bone marrow-derived mesenchymal stromal/stem cells on peripheral blood T cells from rheumatoid arthritis patients". Journal of Tissue Engineering and Regenerative Medicine (2019): https://doi.org/10.1002/term.2958.
    10.1002/term.2958
  21. Laranjeira, Paula. "CD43 and CD49d from the B-Cell Chronic Lymphoproliferative Disorders Diagnostic Panel Are Useful to Detect Erythroid Dysplasia". Cytometry Part B: Clinical Cytometry (2019): http://dx.doi.org/10.1002/cyto.b.21792.
    10.1002/cyto.b.21792
  22. Laranjeira, Paula. "Functional Impairment of Circulating FceRI+ Monocytes and Myeloid Dendritic Cells in Hepatocellular Carcinoma and Cholangiocarcinoma Patients". (2019): http://dx.doi.org/10.1002/cyto.b.21777.
    10.1002/cyto.b.21777
  23. C. Martín-Sierra; P. Laranjeira; M.R. Domingues; A. Paiva. "Lipoxidation and cancer immunity". Redox Biology (2019): 101103-101103. https://doi.org/10.1016/j.redox.2019.101103.
    10.1016/j.redox.2019.101103
  24. Simone Colombo; Carmen Martín-Sierra; Tânia Melo; Paula Laranjeira; Artur Paiva; Pedro Domingues; M. Rosário Domingues. "Modulation of the inflammatory response of immune cells in human peripheral blood by oxidized arachidonoyl aminophospholipids". Archives of Biochemistry and Biophysics 660 (2018): 64-71. https://doi.org/10.1016/j.abb.2018.10.003.
    10.1016/j.abb.2018.10.003
  25. Laranjeira, Paula. "Impact of cardiac resynchronization therapy on circulating IL-17 producing cells in patients with advanced heart failure.". Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing (2018): https://doi.org/10.1007/s10840-018-0491-3.
    10.1007/s10840-018-0491-3
  26. Paula Laranjeira; Marta Duque; Martin Vojtek; Maria J. Inácio; Isabel Silva; Ana C. Mamede; Mafalda Laranjo; et al. "Amniotic membrane extract differentially regulates human peripheral blood T cell subsets, monocyte subpopulations and myeloid dendritic cells". Cell and Tissue Research 373 2 (2018): 459-476. https://doi.org/10.1007/s00441-018-2822-1.
    10.1007/s00441-018-2822-1
  27. Laranjeira, Paula; Gomes, Joana; Pedreiro, Susana; Pedrosa, Monia; Martinho, Antonio; Antunes, Brigida; Ribeiro, Tania; et al. "Human Bone Marrow-Derived Mesenchymal Stromal Cells Differentially Inhibit Cytokine Production by Peripheral Blood Monocytes Subpopulations and Myeloid Dendritic Cells". Stem Cells International 2015 2015 (2015): 1-15.
    Published • 10.1155/2015/819084
  28. Laranjeira, Paula; Rodrigues, Raquel; Carvalheiro, Tiago; Constanço, Conceição; Vitória, Helena; Matarraz, Sergio; Trindade, Hélder; Órfão, Alberto; Paiva, Artur. "Expression of CD44 and CD35 during normal and myelodysplastic erythropoiesis". Leukemia Research 39 3 (2015): 361-370.
    Published • 10.1016/j.leukres.2014.12.009
  29. Laranjeira, Paula; Pedrosa, Monia; Pedreiro, Susana; Gomes, Joana; Martinho, Antonio; Antunes, Brigida; Ribeiro, Tania; et al. "Effect of human bone marrow mesenchymal stromal cells on cytokine production by peripheral blood naive, memory, and effector T cells". Stem Cell Research & Therapy 6 1 (2015): 3-3.
    Published • 10.1186/scrt537
  30. Ribeiro, Andreia; Laranjeira, Paula; Mendes, Sandrine; Velada, Isabel; Leite, Cristiana; Andrade, Pedro; Santos, Francisco; et al. "Mesenchymal stem cells from umbilical cord matrix, adipose tissue and bone marrow exhibit different capability to suppress peripheral blood B, natural killer and T cells". Stem Cell Research & Therapy 4 5 (2013): 125-125.
    Published • 10.1186/scrt336
  31. Simões, Cláudia; Silva, Ana Cristina; Domingues, Pedro; Laranjeira, Paula; Paiva, Artur; Domingues, M. Rosário M.. "Modified phosphatidylethanolamines induce different levels of cytokine expression in monocytes and dendritic cells". Chemistry and Physics of Lipids 175-176 (2013): 57-64.
    Published • 10.1016/j.chemphyslip.2013.07.008
  32. Henriques, Ana; Gomes, Vera; Duarte, Cátia; Pedreiro, Susana; Carvalheiro, Tiago; Areias, Marlene; Caseiro, Armando; et al. "Distribution and functional plasticity of peripheral blood Th(c)17 and Th(c)1 in rheumatoid arthritis". Rheumatology International 33 8 (2013): 2093-2099.
    Published • 10.1007/s00296-013-2703-6
  33. Simões, Cláudia; Silva, Ana Cristina; Domingues, Pedro; Laranjeira, Paula; Paiva, Artur; Domingues, M. Rosário M.. "Phosphatidylethanolamines Glycation, Oxidation, and Glycoxidation: Effects on Monocyte and Dendritic Cell Stimulation". Cell Biochemistry and Biophysics 66 3 (2012): 477-487.
    Published • 10.1007/s12013-012-9495-2
  34. Matarraz, Sergio; Teodosio, Cristina; Fernandez, Carlos; Albors, Manuel; Jara-Acevedo, María; López, Antonio; Gonzalez-Gonzalez, María; et al. "The Proliferation Index of Specific Bone Marrow Cell Compartments from Myelodysplastic Syndromes Is Associated with the Diagnostic and Patient Outcome". PLoS ONE 7 8 (2012): e44321-e44321.
    Published • 10.1371/journal.pone.0044321
  35. Silva, Raquel Nunes da; Silva, Ana Cristina; Maciel, Elisabete; Simões, Cláudia; Horta, Sara; Laranjeira, Paula; Paiva, Artur; Domingues, Pedro; Domingues, M. Rosário M.. "Evaluation of the capacity of oxidized phosphatidylserines to induce the expression of cytokines in monocytes and dendritic cells". Archives of Biochemistry and Biophysics 525 1 (2012): 9-15.
    Published • 10.1016/j.abb.2012.05.022
  36. Morgado, José Mário; Rama, Luís; Silva, Isabel; de Jesus Inácio, Maria; Henriques, Ana; Laranjeira, Paula; Pedreiro, Susana; et al. "Cytokine production by monocytes, neutrophils, and dendritic cells is hampered by long-term intensive training in elite swimmers". European Journal of Applied Physiology 112 2 (2011): 471-482.
    Published • 10.1007/s00421-011-1966-4
  37. Henriques, Ana; Inês, Luís; Carvalheiro, Tiago; Couto, Maura; Andrade, Ângela; Pedreiro, Susana; Laranjeira, Paula; et al. "Functional characterization of peripheral blood dendritic cells and monocytes in systemic lupus erythematosus". Rheumatology International 32 4 (2011): 863-869.
    Published • 10.1007/s00296-010-1709-6
  38. Matarraz, Sergio; López, Antonio; Barrena, Susana; Fernandez, Carlos; Jensen, Evan; Flores, Juan; Rasillo, Ana; et al. "Bone marrow cells from myelodysplastic syndromes show altered immunophenotypic profiles that may contribute to the diagnosis and prognostic stratification of the disease: A pilot study on a series of 56 patients". Cytometry Part B: Clinical Cytometry 78 3 (2010): 154-168.
    Published • 10.1002/cyto.b.20513
  39. Tralhão, J.G.; Hoti, E.; Serôdio, M.; Laranjeiro, P.; Paiva, A.; Abrantes, A.M.; Pais, M.L.; Botelho, M.F.; Castro Sousa, F.. "Perioperative tumor cell dissemination in patients with primary or metastatic colorectal cancer". European Journal of Surgical Oncology (EJSO) 36 2 (2010): 125-129.
    Published • 10.1016/j.ejso.2009.07.003
  40. Henriques, Ana; Inês, Luís; Couto, Maura; Pedreiro, Susana; Santos, Catarina; Magalhães, Mariana; Santos, Paulo; et al. "Frequency and functional activity of Th17, Tc17 and other T-cell subsets in Systemic Lupus Erythematosus". To compare frequency and functional activity of peripheral blood (PB) Th(c)17, Th(c)1 and Treg cells and the amount of type 2 cytokines mRNA we recruited SLE patients in active (n = 15) and inactive disease (n = 19) and healthy age- and gender-matched controls (n = 15). The study of Th(c)17, Th(c)1 and Treg cells was done by flow cytometry and cytokine mRNA by real-time PCR. Compared to NC, SLE pa 264 1 (2010): 97-103. http://hdl.handle.net/10174/21618.
    10.1016/j.cellimm.2010.05.004
  41. Cortesão, Emília; Espadana, Ana; Laranjeiro, Paula; Jara, Maria; Orfão, Alberto. "Successful treatment with VAD of a myelodysplastic syndrome occurring during the course of a smoldering multiple myeloma". Leukemia Research 33 1 (2009): 195-197.
    Published • 10.1016/j.leukres.2008.04.009
  42. Morgado, José Mário; Pratas, Rui; Laranjeira, Paula; Henriques, Ana; Crespo, Inês; Regateiro, Fernando; Paiva, Artur. "The phenotypical and functional characteristics of cord blood monocytes and CD14-/low/CD16+ dendritic cells can be relevant to the development of cellular immune responses after transplantation". Transplant Immunology 19 1 (2008): 55-63.
    Published • 10.1016/j.trim.2007.11.002
Thesis / Dissertation
  1. Martín Sierra, Maria Del Carmen. "Lipidomics and immune system evaluation in hepatocellular carcinoma and cholangiocarcinoma". PhD, 2020. http://hdl.handle.net/10773/30162.
  2. Laranjeira, Paula Margarida dos Santos. "Immunomodulation by mesenchymal stromal cells: relevance to mesenchymal stromal cells-based therapies". PhD, 2016. http://hdl.handle.net/10316/29602.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2007 Myelodisplastic syndromes: immunophenotypic features of CD34 negative bone marrow cells from different hematopoietic lineages XLIX Reunión Nacional de la AEHH y XXIII Congreso Nacional de la SETH
(Pamplona, Spain)
2007 Papel das quimiocinas na previsão da resposta à terapêutica em Esclerose Múltipla VII Jornadas de Análises Clínicas e Saúde Pública
Escola Superior das Tecnologias da Saúde de Coimbra (Coimbra, Portugal)
2004 Citometria de fluxo: princípios básicos e aplicações clínicas V Jornadas de Engenharia Electrotécnica e das Telecomunicações
Escola Superior de Tecnologia do Instituto Politécnico de Castelo Branco (Castelo Branco, Portugal)

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2021/11/23 - 2021/11/23 "Immune Checkpoints - Immunobiology" talk in the course "Flow cytometry advances in solid tumors" - duration: 4 hours. (Outros) Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2011 - 2011 Curso de imunologia [Immunology course] Extensão e divulgação científica (Curso médio) Sindicato das Ciências e Tecnologias da Saúde e Centro de Histocompatibilidade do Centro, Portugal
2009 - 2009 Curso de actualização em imunologia [Immunology updating course] Extensão e divulgação científica (Curso médio) Centro de Histocompatibilidade do Centro (Coimbra) e pela Escola Superior de Saúde Jean Piaget Nordeste, Portugal
2005 - 2009 Imunologia [Immunology] (Licenciatura) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2004 - 2009 Oncobiologia [Oncobiology] (Licenciatura) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2004 - 2009 Investigação Aplicada [Applied Research] Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
2003 - 2009 Projecto de Investigação [Research Project] (Licenciatura) Instituto Politécnico de Castelo Branco Escola Superior de Saúde Dr Lopes Dias, Portugal
Distinctions

Other distinction

2020 Bolsa SPD - GIFT
Sociedade Portuguesa de Diabetologia, Portugal