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Inês Marques is a research assistant working in the Gut-Brain axis group at CNC-UC, University of Coimbra. She completed her undergraduate education in Biology at the University of Coimbra in 2022, during which she was awarded a Scientific Initiation Grant by the Portuguese Foundation for Science and Technology (FCT) to study enteric mitochondrial dynamics in a Parkinson's disease mouse model. She then recently graduated from the MRes in Molecular and Cellular Biosciences at Imperial College London (UK) in 2023, where she focused her studies on bacterial competition in the gut (project 1) and T cell activation dynamics (project 2). With a background in microbiology and immunology, she is currently interested in studying how the gut microbiome shapes host health and disease, specifically in the context of gut-brain immune dynamics. She has experience in a variety of techniques such as bacterial and mammalian cell culture, retroviral gene transduction, qPCR, flow cytometry, tissue sectioning and confocal microscopy. Moreover, she co-authored four research publications, one book chapter, three poster presentations and inclusively received a second place award for a first-author poster presentation.
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Identification

Personal identification

Full name
Inês José Melo Marques

Citation names

  • Marques, Inês
  • Melo-Marques I

Author identifiers

Ciência ID
EA11-1237-4C67
ORCID iD
0000-0003-2128-296X

Email addresses

  • ines.marques@cnc.uc.pt (Professional)

Addresses

  • Faculdade de Medicina da Universidade de Coimbra, Rua Larga, Pólo I, 1º andar, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Microbiology
  • Natural sciences - Biological Sciences - Cell Biology
  • Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Proficiency (C2) Advanced (C1) Proficiency (C2) Advanced (C1)
Education
Degree Classification
2024/05/06 - 2024/05/17
Concluded
 FELASA Accredited Laboratory Animal Science Course (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022 - 2023
Concluded
 MRes Molecular and Cellular Biosciences (Master)
Major in Microbiology and Immunology
Imperial College London, United Kingdom
"Project 1: Nutrient utilisation by gut commensal bacteria Project 2: Investigation of TCR signalling and cytokine effects on T cell activation using a unique fluorescent protein" (THESIS/DISSERTATION)
 Distinction
2019 - 2022
Concluded
 Biologia (Licenciatura)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Mitochondrial dysfunction as an activator of innate immunity in the ileum of a Parkinson’s disease mouse model" (THESIS/DISSERTATION)
 17
Affiliation

Science

Category
Host institution 		Employer
2020/07 - 2022/09 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2021/09 - 2021/10 Research Trainee (Research) Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal

Others

Category
Host institution 		Employer
2023/11 - Current Research assistant Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Projects

Grant

Designation Funders
2021/09/01 - 2021/09/30 Assessment of mitochondrial network integrity on ileal neurons in a Parkinson’s disease mouse model
4539 (UC)
Scientific Initiation Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book chapter
  1. Candeias E, Nunes-Costa D, Pereira-Santos AR, Magalhães JD, Melo-Marques I, Guedes B, Esteves AR, Empadinhas N, Cardoso. "Neurotoxicity induced by the microbial metabolite ß-methylamino-L-alanine: pathways and mechanisms". 747–778-747–778. Elsevier, 2024.
    10.1016/b978-0-443-23763-8.00068-3
Conference poster
  1. Candeias E, Melo-Marques I, Munoz-Pinto M, Esteves AR, Magalhães JD, Carneiro DR, Empadinhas N, Cardoso SM. "The gut-immune-brain axis in Parkinson disease". Paper presented in AD/PD 2023 - International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders, 2023.
  2. Melo-Marques I, Munoz-Pinto M, Candeias E, Esteves AR, Cardoso SM. "Mitochondrial dysfunction triggers ileum innate immunity in a PD mouse model". Paper presented in VI MeetLab Coimbra (University of Coimbra), 2022.
  3. Magalhães JD, Silva DF, Melo-Marques I, Candeias E, Empadinhas N, Cardoso SM. "Listeria monocytogenes infection paradigm to “gut-first PD”". Paper presented in BEB Day 2022 – The Overview Effect (Coimbra, Portugal), 2022.
Journal article
  1. Inês Melo-Marques; Sandra Morais Cardoso; Nuno Empadinhas. "Bacterial extracellular vesicles at the interface of gut microbiota and immunity". Gut Microbes (2024): https://doi.org/10.1080/19490976.2024.2396494.
    10.1080/19490976.2024.2396494
  2. Mário F. Munoz-Pinto; Emanuel Candeias; Inês Melo-Marques; A. Raquel Esteves; Ana Maranha; João D. Magalhães; Diogo Reis Carneiro; et al. "Gut-first Parkinson’s disease is encoded by gut dysbiome". Molecular Neurodegeneration 19 1 (2024): http://dx.doi.org/10.1186/s13024-024-00766-0.
    10.1186/s13024-024-00766-0
  3. Maranha A, Alarico S, Nunes-Costa D, Melo-Marques I, Roxo I, Castanheira P, Caramelo O, Empadinhas N. "Drinking Water Microbiota, Entero-Mammary Pathways, and Breast Cancer: Focus on Nontuberculous Mycobacteria". Microorganisms (2024): https://doi.org/10.3390/microorganisms12071425.
    10.3390/microorganisms12071425
  4. Magalhães JD, Candeias E, Melo-Marques I, Abreu AE, Pereira-Santos AR, Esteves AR, Cardoso SM, Empadinhas N. "Nocardia cyriacigeorgica Elicits Gut Disturbances in a Leaky Gut Model of Colitis, but Not the Harmful Cascade Leading to Gut-First Parkinson’s Disease". International Journal of Molecular Sciences (2024): https://doi.org/10.3390/ijms25063423.
    10.3390/ijms25063423
  5. Bon L, Banas A, Dias I, Melo-Marques I, Cardoso SM, Chaves S, Santos MA. "New Multitarget Rivastigmine–Indole Hybrids as Potential Drug Candidates for Alzheimer’s Disease". Pharmaceutics (2024): https://doi.org/10.3390/pharmaceutics16020281.
    10.3390/pharmaceutics16020281
  6. Horrocks V, King OG, Yip AYG, Melo-Marques I, McDonald JAK. "Role of the gut microbiota in nutrient competition and protection against intestinal pathogen colonization.". Microbiology (Reading, England) (2023): http://europepmc.org/abstract/med/37540126.
    10.1099/mic.0.001377
  7. Magalhães JD, Candeias E, Melo-Marques I, Silva DF, Esteves AR, Empadinhas N, Cardoso SM. "Intestinal infection triggers mitochondria-mediated a-synuclein pathology: relevance to Parkinson's disease.". Cellular and molecular life sciences : CMLS (2023): http://europepmc.org/abstract/med/37249642.
    10.1007/s00018-023-04819-3
Thesis / Dissertation
  1. "Nutrient utilisation by gut commensal bacteria". Master, Imperial College London, 2023.
  2. "Investigation of TCR signalling and cytokine effects on T cell activation using a unique fluorescent protein". Master, Imperial College London, 2023.
  3. "Mitochondrial dysfunction as an activator of innate immunity in the ileum of a Parkinson’s disease mouse model". Degree, Universidade de Coimbra, 2022.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02/15 Research database guidelines for successful utilization Aula TP para alunos da disciplina de Biologia do Envelhecimento

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/04/11 - 2024/04/11 Volunteer at Brain Awareness Week 2024 (2024/04/11)
2023/12/20 - 2023/12/20 Volunteer at CIBB Meeting 2023 (2023/12/20)
Conference (Other)
 Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
2022/07/15 - 2022/07/15 Volunteer at "Académica sobre rodas" science communication activities (2022/07/15)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2024/03/06 - 2024/03/06 Attendance to First Aid Training
Workshop
 Formação - Primeiros socorros
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2023/05/19 - 2023/05/19 Attendance at "Advances and Innovations in Clinical Infectious Diseases"
Symposium
 Advances and Innovations in Clinical Infectious Diseases
University College London, United Kingdom
2021 - 2021 Attendance at "Biologia ao fim da tarde" seminar series
Seminar
 Biologia ao fim da tarde
Universidade do Porto, Portugal
2020 - 2020 Attendace at "IV MeetLab Coimbra"
Conference
 IV MeetLab Coimbra
Universidade de Coimbra, Portugal

Mentoring / Tutoring

Topic Student name
2022 - Current Lab supervisor Several students
Distinctions

Award

2022 2nd place in poster presentation (VI MeetLab Coimbra)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2019 Prémio "UC à frente"
Universidade de Coimbra, Portugal