Rafael Martins Galupa (EA11-3D2C-13D9)

Curriculum Vitae

Rafael Galupa é Doutorado em Ciências da Vida pela Université Paris-Saclay (2017) e Mestre em Biomedicina pelo Karolinska Institutet (2013). Em 2010, concluiu a Licenciatura em Biologia – Ramo Biologia Molecular e Genética na Faculdade de Ciências da Universidade de Lisboa, pela qual recebeu vários prémios de melhor estudante, e no mesmo ano obteve uma bolsa da Comissão Europeia para uma estadia científica no Institut Curie, em Paris. Desde 2018, e após obtenção de uma bolsa Marie Sklodowska-Curie/EIPOD, é investigador pós-doutorado no Laboratório Europeu de Biologia Molecular (EMBL), em Heidelberg. Desde 2020, é também cofundador e codiretor da Cartas com Ciência, organização sem fins lucrativos que atua na área da educação em ciência e justiça social nos países de língua portuguesa. Como (co)autor, Rafael publicou 15 artigos em revistas científicas com revisão por pares, incluindo Nature, Cell, Nature Genetics, Molecular Cell. Orador convidado em 5 eventos científicos, 12 seminários de mestrado ou licenciatura e mais de uma dezena de evetos de divulgação científica. Supervisiona ou supervisionou até à data 4 estudantes de doutoramento (México, Portugal, Reino Unido), 2 estudantes de mestrado (Croácia, Reino Unido) e 2 estudantes de licenciatura (França, Reino Unido). Em articulação com as suas atividades de investigação, faz ou fez parte de várias sociedades científicas, e de comissões consultivas e organizadoras, como o Fórum de Igualdade, Diversidade e Inclusão do EMBL.

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Identification

Personal identification

Full name: Rafael Martins Galupa

Citation names

Galupa, Rafael

Author identifiers

Ciência ID: EA11-3D2C-13D9
ORCID iD: 0000-0001-7319-043X

Email addresses

rafael.galupa@embl.de (Professional)
rafael.galupa@cartascomciencia.org (Professional)

Websites

https://www.cartascomciencia.org/equipa (Professional)
https://scholar.google.com/citations?user=EXJmG9UAAAAJ&hl=en (Scholar)
https://www.embl.org/people/person/ab51d2e11e15446c647a05ad3084bba14803f01fd3bd5d1deb9cf851feffe96d/ (Scholar)

Knowledge fields

Natural sciences - Biological Sciences - Genetics and Heredity
Natural sciences - Biological Sciences - Developmental Biology
Social Sciences - Educational Sciences

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)
French	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Croatian	Beginner (A1)	Elementary (A2)	Elementary (A2)	Beginner (A1)	Beginner (A1)

Education

	Degree	Classification
2013/10 - 2017/09 Concluded	Sciences de la vie et de la santé (Doctorat) Université Paris-Saclay, France "Exploring the structural and functional dynamics of the X-inactivation centre locus during development" (THESIS/DISSERTATION)
2011/08 - 2013/06 Concluded	Biomedicine (Master) Karolinska Institutet, Sweden "The role of the long non-coding RNA Linx in X-inactivation" (THESIS/DISSERTATION)
2007/09 - 2010/07 Concluded	Biologia (Licenciatura) Major in Biologia Molecular e Genética Universidade de Lisboa Faculdade de Ciências, Portugal	18

Affiliation

Science

	Category Host institution	Employer
2018/06 - Current	Postdoc (Research)	European Molecular Biology Laboratory, Germany

2017/10 - 2018/05	Postdoc (Research)	Institut Curie Centre de Recherche, France

2013/10 - 2017/09	Researcher (Research)	Institut Curie Centre de Recherche, France

2013/01 - 2013/09	Research Trainee (Research)	Institut Curie Centre de Recherche, France

2012 - 2012	Research Trainee (Research)	Karolinska Institutet Institutionen för mikrobiologi tumör- och cellbiologi, Sweden

2011 - 2011	Research Trainee (Research)	Institut Curie Centre de Recherche, France

2010 - 2010	Research Trainee (Research)	Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal

2008 - 2010	Research Trainee (Research)	Universidade de Lisboa Faculdade de Ciências, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2015 - Current	Invited Assistant (University Teacher)	Université de Paris IUT Paris Diderot, France

2018 - 2020	Invited Assistant (University Teacher)	Universidade de Lisboa Faculdade de Ciências, Portugal

Projects

Grant

	Designation	Funders
2018/06/03 - Current	Building synthetic gene regulatory networks to explore transcriptional regulation mechanisms during development NA Post-doc Fellow European Molecular Biology Laboratory, Germany	Ongoing

Other

	Designation	Funders
2020/05/05 - Current	Cartas com Ciência NA Co-diretor	Ongoing

Outputs

Publications

Conference abstract	"Avaliar em contextos de Cooperação Internacional para o Desenvolvimento: um referencial em construção focado na Educação em Ciência". Paper presented in III Encontro Internacional de Língua Portuguesa e Relações Lusófonas (LUSOCONF2021), 2021. "Educação (não) formal em Ciência(s): Partilha da experiência de um programa de troca de cartas entre estudantes e cientistas". Paper presented in V Bienal STEM+L, 2021. "Avaliar para aprender com a Cartas com Ciência: um exemplo de parceria institucional em prol da transformação social em comunidades de língua portuguesa". Paper presented in 11.ª Conferência FORGES (Fórum da Gestão do Ensino Superior nos países e regiões de Língua Portuguesa: A Cooperação no Ensino Superior dos Países e Regiões de Língua Portuguesa Perante os Desafios Globais), 2021.
Journal article	Giulia Furlan; Rafael Galupa. "Mechanisms of Choice in X-Chromosome Inactivation". Cells (2022): https://www.mdpi.com/2073-4409/11/3/535. 10.3390/cells11030535 Tsai, Albert; Galupa, Rafael; Crocker, Justin. "Robust and efficient gene regulation through localized nuclear microenvironments". Development 147 19 (2020): dev161430. http://dx.doi.org/10.1242/dev.161430. 10.1242/dev.161430 Galupa, Rafael; Crocker, Justin. "Enhancer-Promoter Communication: Thinking Outside the TAD". Trends in Genetics 36 7 (2020): 459-461. http://dx.doi.org/10.1016/j.tig.2020.04.002. 10.1016/j.tig.2020.04.002 Collombet, Samuel; Ranisavljevic, Noémie; Nagano, Takashi; Varnai, Csilla; Shisode, Tarak; Leung, Wing; Piolot, Tristan; et al. "Parental-to-embryo switch of chromosome organization in early embryogenesis". Nature 580 7801 (2020): 142-146. http://dx.doi.org/10.1038/s41586-020-2125-z. 10.1038/s41586-020-2125-z Galupa, Rafael; Nora, Elphège Pierre; Worsley-Hunt, Rebecca; Picard, Christel; Gard, Chris; van Bemmel, Joke Gerarda; Servant, Nicolas; et al. "A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary". Molecular Cell 77 2 (2020): 352-367.e8. http://dx.doi.org/10.1016/j.molcel.2019.10.030. 10.1016/j.molcel.2019.10.030 van Bemmel, Joke G.; Galupa, Rafael; Gard, Chris; Servant, Nicolas; Picard, Christel; Davies, James; Szempruch, Anthony James; et al. "The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist". Nature Genetics 51 6 (2019): 1024-1034. http://dx.doi.org/10.1038/s41588-019-0412-0. 10.1038/s41588-019-0412-0 Galupa R; Heard E. "X-Chromosome Inactivation: A Crossroads Between Chromosome Architecture and Gene Regulation.". Annual review of genetics (2018): http://europepmc.org/abstract/med/30256677. 10.1146/annurev-genet-120116-024611 Furlan G; Gutierrez Hernandez N; Huret C; Galupa R; van Bemmel JG; Romito A; Heard E; Morey C; Rougeulle C. "The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products.". Molecular cell (2018): http://europepmc.org/abstract/med/29706539. 10.1016/j.molcel.2018.03.024 Galupa R; Heard E. "Topologically Associating Domains in Chromosome Architecture and Gene Regulatory Landscapes during Development, Disease, and Evolution.". Cold Spring Harbor symposia on quantitative biology (2018): http://europepmc.org/abstract/med/29686034. 10.1101/sqb.2017.82.035030 Galupa R; Heard E. "X-chromosome inactivation: new insights into cis and trans regulation.". Current opinion in genetics & development (2015): http://europepmc.org/abstract/med/26004255. 10.1016/j.gde.2015.04.002 L. Giorgetti; R. Galupa; E. P. Nora; T. Piolot; F. Lam; J. Dekker; G. Tiana; E. Heard. "Predictive polymer modeling reveals coupled fluctuations in chromosome conformation and transcription". (2014): http://hdl.handle.net/2434/235049. 10.1016/j.cell.2014.03.025
Report	Galupa, Rafael Martins. 2011. Histopatologia da doença da murchidão do pinheiro em Pinus pinaster infectados pelo nemátodo Bursaphelenchus xylophilus. http://hdl.handle.net/10451/3468.

Other

Other output

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure. 2017. Borensztein, Maud; Syx, Laurène; Ancelin, Katia; Diabangouaya, Patricia; Picard, Christel; Liu, Tao; Liang, Jun-Bin; et al. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337400/.
10.1038/nsmb.3365
Contribution of epigenetic landscapes and transcription factors to X-chromosome reactivation in the inner cell mass. 2017. Borensztein, Maud; Okamoto, Ikuhiro; Syx, Laurène; Guilbaud, Guillaume; Picard, Christel; Ancelin, Katia; Galupa, Rafael; et al. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5670228/.
10.1038/s41467-017-01415-5

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2019	Solving the Xic puzzle: a TAD challenging	Edith Heard – 17 years of eXisting at Curie Institut Curie (Paris, France)
2018	A conserved element across a TAD boundary regulates Xist expression to modulate choice in mouse X inactivation	The X chromosome – Genetics and Epigenetics Collège de France (Paris, France)
2018	(Poster) TAD architecture and non-coding RNA loci in the regulation of X-chromosome inactivation	Keystone Symposia: Chromatin Architecture and Chromosome Organisation (Whistler, Canada)
2017	Dissecting structure and function at the Xic locus	Internal seminars Friedrich Miescher Institute (Basileia, Switzerland)
2017	(Poster) The structural and regulatory landscape of the X-inactivation centre	EMBL Conference: Chromatin and Epigenetics (Heidelberg, Germany)
2017	The structural and regulatory landscape of the X-inactivation centre	Abcam Meeting: Chromatin and transcriptional silencing (Paris, France)
2016	The structural and regulatory puzzle of the Xic	8ème Colloque Club de Belles Souris IGBMC (Strasbourg, France)
2016	X inactivation: new insights into cis and trans regulation	Systems Biology Workshop AgroBio (Melbourne, Australia)
2016	(Poster) The noncoding Linx locus is a new regulator of the probability of choice	X-chromosome inactivation Royal Society (Londres, United Kingdom)
2015	(Poster) The structural and regulatory puzzle of the X-inactivation centre	EMBL Conference: From Functional Genomics to Systems Biology EMBL (Heidelberg, Germany)
2014	The structural and regulatory puzzle of the Xic	1st Meeting of FSER Laureates Institut Curie (Paris, France)
2014	(Poster) Genetic dissection of the structural and regulatory landscape of the Xic and its lncRNAs	Keystone Symposia: Long noncoding RNAs, marching toward mechanism (Santa Fe, United States)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2021 - Current	Exploring enhancer function during fruit fly development Supervisor of Esther Karumbi
2019 - Current	Delimiting the mechanisms for encoding synthetic pattern formation in the early embryo of Drosophila melanogaster Co-supervisor of Gilberto Alvarez
2017 - 2021	Interrogating the complex role of UBX & multi-enhancer transcriptional hubs throughout development Co-supervisor of Mariana Rama Pedro Alves
2018 - 2018	A synthetic genetic toolbox to explore developmental gene regulatory networks Supervisor of Tin Kocijan
2016 - 2018	Unravelling the interplay between transcription and chromosome conformation in XCI Co-supervisor of Chris Gard
2015 - 2016	Exploring The Structure And Function Of The X-Inactivation Centre During Mouse Embryonic Stem Cell Differentiation Co-supervisor of Chris Gard

Event organisation

	Event name Type of event (Role)	Institution / Organization
2019 - 2019	Retiro Científico de Investigadores Pós-doutorados (EMBL) (2019)
2014 - 2016	Seminários Científicos "Ratatouille" (Institut Curie) (2014)
2014 - 2014	Retiro Científico do Labex DEEP (Institut Curie) (2014)
2014 - 2014	Retiro Científico para Estudantes de Doutoramento (Institut Curie) (2014)

Association member

	Society Organization name	Role
2018 - Current	Genetics Society of America
2017 - Current	Societé Française de Génétique
2017 - Current	Societé Française de Biologie du Développement

Committee member

	Activity description Role	Institution / Organization
2021 - Current	Fórum para Igualdade, Diversidade e Inclusão (EMBL) Member
2019 - Current	Trusted Advisors Programme

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2015 - Current	Génomique	Magistère de Génétique (Magister)	Université de Paris, France
2018 - 2020	Fronteiras de Investigação em Biologia	Biologia Molecular e Genética (Mestrado integrado)	Universidade de Lisboa Faculdade de Ciências, Portugal
2016 - 2016	Épigénétique	Magistère de Génétique (Magister)	Université de Paris, France

Distinctions

Award

2010	Prémio Melhores Alunos Graduados Universidade de Lisboa Faculdade de Ciências, Portugal
2008	Prémio Brotero Jardim Botânico de Lisboa, Portugal
2008	Prémio Melhores Alunos 1º Ano 1ª Vez (UL) Universidade de Lisboa, Portugal
2008	Prémio Melhores Alunos 1º Ano 1ª Vez (FCUL) Universidade de Lisboa Faculdade de Ciências, Portugal

Other distinction

2018	EIPOD/Marie Sklodowska-Curie Postdoctoral Fellowship European Molecular Biology Laboratory, Germany
2016	Bourse 4ème année thèse Fondation pour la Recherche Médicale, France
2013	Scholarship for Internship Abroad Karolinska Institutet, Sweden
2013	Erasmus Placement Scholarship Karolinska Institutet, Sweden
2013	Master's Scholarship Karolinska Institutet, Sweden
2012	Master's Scholarship Karolinska Institutet, Sweden
2011	Leonardo Da Vinci Fellowship Universidade de Lisboa Faculdade de Ciências, Portugal
2009	Bolsa Fundação Amadeu Dias Universidade de Lisboa, Portugal
2009	Bolsa de Mérito Universidade de Lisboa Faculdade de Ciências, Portugal
2008	Bolsa de Mérito Universidade de Lisboa Faculdade de Ciências, Portugal
2008	Bolsa de Iniciação à Investigação Científica Universidade de Lisboa Faculdade de Ciências, Portugal