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In Dec. 2011, Ana Fernandes-Platzgummer (AFP) concluded the doctoral program in Bioengineering Systems, jointly offered by Faculty of Sciences and Technology, Universidade Nova de Lisboa, IST ¿ University de Lisboa, School of Engineering, Universidade do Minho and with the support of the MIT-Portugal Program. Since PhD, AFP pursued her investigation at iBB-IST (2012-2016 as post-doctoral fellow; 2016-present as research assistant) focused on developing efficient, scalable and cost-effective production processes for the large-scale ex vivo expansion of human adult cells and the production of their extracellular vesicles in controlled bioreactors. AFP have 34 publications (20 SCI papers, 7 book chapters and 7 proceedings) with ca. 74 co-authors. In Sep. 2019, AFP was hired as an Invited Assistant Professor at IST, and since then she dedicates 15% of her time in teaching activities. She have completed the supervision of 9 MSc students and 6 Laboratory Rotations/Seed Projects of PhD students. Since the 2021, she is Principal Investigator of the ¿Smart bioprocess design for cellular and molecular therapies LAB¿ at SCERG-iBB and currently, she supervises 1 junior PhD researcher, 3 PhD students and 2 master students.
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Identification

Personal identification

Full name
Ana Fernandes-Platzgummer

Citation names

  • Fernandes-Platzgummer, Ana
  • Fernandes, AM

Author identifiers

Ciência ID
EA11-6777-F573
ORCID iD
0000-0002-5367-6528

Email addresses

  • ana.fernandes@tecnico.ulisboa.pt (Professional)

Addresses

  • Instituto Superior Técnico. Av. Rovisco Pais, 1049-001, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Engineering and Technology - Chemical Engineering
  • Engineering and Technology - Industrial Biotechnology - Bioprocessing Technologies
  • Natural sciences - Biological Sciences - Cell Biology

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2012/03/01 - 2016/11/30
Concluded
 Engenharia Bioquímica e Biotecnoclogia (Pós-doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/09/25 - 2013/01/24
Concluded
 Maternity leave (Outros)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2007/11/01 - 2011/12/15
Concluded
 PhD in Bioengineering (MIT-Portugal Program) (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Bioreactor culture systems for the expansion of mouse embryonic stem cells" (THESIS/DISSERTATION)
 Muito Bom
2010/06/01 - 2010/09/30
Concluded
 Maternity leave (Outros)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2005/09/01 - 2007/01/29
Concluded
 Biotecnologia (Engenharia Bioquímica) (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Scale-up of mouse embryonic stem cell expansion in a stirred culture system" (THESIS/DISSERTATION)
 Aprovado
2005
Concluded
 Engenharia Biológica (5 years) (Licenciatura)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Cloning of human targets in eucaryotic expression vectors and generation of serum free transfectants in mammalian cell culture" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2016/12/01 - Current Contracted Researcher (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
2012/02/01 - 2016/11/30 Postdoc (Research) Universidade de Lisboa Instituto Superior Técnico, Portugal
Universidade de Lisboa Instituto Superior Técnico, Portugal
2003/10/05 - 2004/04/30 Visiting Researcher (Research) Universität für Bodenkultur Wien, Austria
Universidade de Lisboa Instituto Superior Técnico, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2019/09/01 - Current Invited Assistant Professor (University Teacher) Universidade de Lisboa Instituto Superior Técnico, Portugal

Others

Category
Host institution 		Employer
2012/09/20 - 2013/01/19 Maternity leave Universidade de Lisboa Instituto Superior Técnico, Portugal
2010/06/01 - 2010/09/30 Maternity Leave Universidade de Lisboa Instituto Superior Técnico, Portugal
Projects

Grant

Designation Funders
2021/09/01 - 2025/08/31 UROPRINT: Urinary bladder bioprinting for fully autologous transplantation
964883 H2020-FETOPEN-2018-2019-2020-01
Researcher
European Union
Ongoing
2020/04/01 - 2025/03/31 AMELIE: Anchored Muscle cELls for IncontinencE
: H2020-SC1-BHC-2018-2020
Researcher
European Union
Ongoing
2022/01/01 - 2024/12/31 Quality by design-centered platform for the manufacturing of CAR-engineered NK cells and extracellular vesicles for immunotherapy
PTDC/EQU-EQU/3708/2021
Principal investigator
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2022/06/30 EXOpro: Development of a scalable manufacturing process for therapeutic human mesenchymal stem/stromal cell-derived exosomes
PTDC/EQU-EQU/31651/2017
Principal investigator
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2019/02/03 - 2021/03/01 NeuroAbetaClear: Development of a scalable manufacturing process for therapeutic human mesenchymal stem/stromal cell-derived exosomes
LISBOA-01-0145-FEDER-031057
Researcher
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Governo da República Portuguesa Ministério da Ciência Tecnologia e Ensino Superior
Concluded
2016/04/01 - 2019/03/31 HSCexpand: Design and operation of a prototype packed-bed reactor for the production of hematopoietic stem/progenitor cells
PTDC/QEQ-EPR/6623/2014
Principal investigator
Universidade de Lisboa Instituto Superior Técnico, Portugal

Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2015/04/01 - 2016/12/31 CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications
info:eu-repo/grantAgreement/FCT/5665-PICT/137185/PT
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2012/03/01 - 2016/11/30 Integrated Bioreactor Operation Towards the Expansion and in situ Selection of Human Hematopoietic Stem/Progenitor Cells
SFRH/BPD/82062/2011
Post-doc Fellow
2011/01/02 - 2013/12/31 Scalable Reactor Systems for the Production of Human Mesenchymal Stem Cells
info:eu-repo/grantAgreement/FCT/3599-PPCDT/114231/PT
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2010/04/01 - 2013/09/13 StemCellQCM - Acoutic detectors for stem cell adhesion and differentiation
info:eu-repo/grantAgreement/FCT/3599-PPCDT/105189/PT
Researcher
Universidade do Algarve Faculdade de Ciências e Tecnologia
Concluded
2009/04/01 - 2013/09 Smart small-scale devices: systems for controlled delivery of bioactive molecules, cell expansion and for sensing cell environment.
info:eu-repo/grantAgreement/FCT/3599-PPCDT/83907/PT
Researcher
Universidade do Algarve Faculdade de Ciências e Tecnologia
2010/01/01 - 2012/12 Exploring human embryonic stem cell fate using 3-D cellular microarrays
info:eu-repo/grantAgreement/FCT/3599-PPCDT/101088/PT
Researcher
Universidade do Algarve Faculdade de Ciências e Tecnologia
2010/01/01 - 2012/12 Integrated Process for the Expansion and Neural Differentiation of Human Embryonic Stem Cells in Stirred Suspension Bioreactors
PTDC/EQU-ERQ/105277/2008
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2007/11/01 - 2011/12/15 Bioreactor culture systems for the expansion of mouse embryonic stem cells
SFRH/BD/36070/2007
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
Concluded

Contract

Designation Funders
2021 - Current Isolation, scalable expansion of human mesenchymal stem/stromal cells (MSCs) and production of MSC-derived extracellular vesicles (EVs) in xeno-free conditions, using CTS reagents of Thermo Fisher
IBB-LT_2021
Researcher
Ongoing
2018/12/01 - 2021/11/30 Bioprocessing Strategies for high productivity in the Culture of Human Stem Cells in Stirred Tank Bioreactors and their downstream
CELLS4ALL H2020-INNOVOUCHER-2018-0039
Researcher
European Union
Ongoing
2019/07/01 - 2021/06/30 MSCellProduction: Produção de Células Estaminais Mesenquimais em conformidade com os requisitos de Boas Práticas de Fabrico
POCI-01-0247-FEDER- 038313
Researcher
Autoridade de Gestão do Programa Operacional Competitividade e Internacionalização
Concluded
2016/12/01 - 2018/11/30 Accelerating progress toward the new era of precision medicine
SAICTPAC/0021/2015
Research Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing

Other

Designation Funders
2016/06/01 - 2017/11/30 Biomanufacturing platform for large-scale production of different stem/progenitor cells for the bioengineering of a porcine whole-liver for transplantation
iBB Internal Grants 2016/2017
Principal investigator
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Universidade de Lisboa Instituto de Bioengenharia e Biociências
Concluded
2016/06/01 - 2017/11/30 Identification and characterization of new antifungals produced by mesenchymal stem/stromal cells: aiming the development of new therapeutic approaches against the fungal pathogen Candida glabrata
iBB internal grants 2016/2017
Principal investigator
Universidade de Lisboa Instituto de Bioengenharia e Biociências, Portugal
 Universidade de Lisboa Instituto de Bioengenharia e Biociências
Concluded
Outputs

Publications

Book chapter
  1. Fernandes-Platzgummer, Ana; Andrade, Pedro Z.; Cabral, Joaquim M. S.; da Silva, Cláudia Lobato. "Scalable Manufacturing of Human Hematopoietic Stem/Progenitor Cells Exploiting a Co-culture Platform with Mesenchymal Stromal Cells". In Methods in Molecular Biology. Springer US, 2020.
    10.1007/7651_2020_289
  2. de Almeida Fuzeta, Miguel; de Matos Branco, André Dargen; Fernandes-Platzgummer, Ana; da Silva, Cláudia Lobato; Cabral, Joaquim M. S.. "Addressing the Manufacturing Challenges of Cell-Based Therapies". In Advances in Biochemical Engineering/Biotechnology. Springer Berlin Heidelberg, 2019.
    10.1007/10_2019_118
  3. Fernandes-Platzgummer, Ana; Badenes, Sara M.; da Silva, Cláudia L.; Cabral, Joaquim M. S.. "Bioreactors for Stem Cell and Mammalian Cell Cultivation". In Bioprocessing Technology for Production of Biopharmaceuticals and Bioproducts, 131-173. John Wiley & Sons, Inc., 2018.
    10.1002/9781119378341.ch4
  4. Fernandes-Platzgummer, Ana; Carmelo, Joana G.; da Silva, Cláudia Lobato; Cabral, Joaquim M. S.. "Clinical-Grade Manufacturing of Therapeutic Human Mesenchymal Stem/Stromal Cells in Microcarrier-Based Culture Systems". In Methods in Molecular Biology, 375-388. Springer New York, 2016.
    10.1007/978-1-4939-3584-0_22
  5. Badenes, S.M.; Fernandes-Platzgummer, A.; Rodrigues, C.A.V.; Diogo, M.M.; Da Silva, C.L.; Cabral, J.M.S.. "Microcarrier Culture Systems for Stem Cell Manufacturing". In Methods in Molecular Biology. 2016.
    10.1016/B978-0-444-63265-4.00004-2
  6. Carmelo, J.G.; Fernandes-Platzgummer, A.; Cabral, J.M.S.; Lobato da Silva, C.. "Scalable ex vivo expansion of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems". In Methods in Molecular Biology. 2015.
    10.1007/7651_2014_100
  7. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; da Silva, Cláudia Lobato; Cabral, Joaquim M. S.. "Large-Scale Expansion of Mouse Embryonic Stem Cells on Microcarriers". In Embryonic Stem Cell Therapy for Osteo-Degenerative Diseases, 121-134. Humana Press, 2010.
    10.1007/978-1-60761-962-8_8
Conference abstract
  1. Isabel Doutor; Branco, André; Fernandes-Platzgummer, Ana. "Optimization of the Ex Vivo Expansion of Umbilical Cord Blood Natural Killer Cells and Production of Derived Extracellular Vesicles Under Static Conditions"". 2023.
  2. Doutor, Isabel; Branco, André; Fernandes-Platzgummer, Ana. "Technology-driven platform for the manufacturing of extracellular vesicles derived from umbilical cord blood CAR- engineered NK cells for immunotherapy". Paper presented in IST PhD Open Days, 2022.
  3. Carreira, Maria Catarina; Branco, André; 601D-DE5F-A9B0. "Influence of culture media on Mesenchymal Stromal Cell expansion and hematopoietic support capacity". Paper presented in NInTec Science Days, Instituto Superior Técnico, 2022.
  4. Carreira, Maria Catarina; Fernandes-Platzgummer, Ana. "Influence of Culture Conditions on The Ex-Vivo Expansion and Hematopoietic Supportive Capacity of Human Mesenchymal Stromal Cells". Paper presented in 11th International Molecular Biology and Biotechnology Congress (Online), Çukurova University (Turquia), 2022.
  5. Fuzeta, Miguel de Almeida ; Oliveira, FD; Costa, AC; Fernandes-Platzgummer, Ana; Jung, S.; Tseng, RJ; Milligan, W.; et al. "Scalable Production of Human Mesenchymal Stromal Cell (MSC)-Derived Extracellular Vesicles in Microcarrier-based Bioreactors under Xeno(geneic)-free Conditions". Paper presented in International Society for Cell and Gene Therapy Meeting (Virtual), Paris, 2020.
  6. Cunha, Raquel; Calado, Cecília Ribeiro da Cruz ; Cabral, Joaquim; Silva, Cláudia; Fernandes-Platzgummer, Ana. "Development of scalable processes to produce therapeutic MSC-derived extracellular vesicles". Paper presented in International Society for Extracellular Vesicles Meeting - ISEV2020 (virtual), Philadelphia, 2020.
  7. Fernandes-Platzgummer, Ana; Rosa, Sara; Silva, Ricardo M.; Cunha, Raquel; Fuzeta, Miguel de Almeida ; Calado, Cecília Ribeiro da Cruz ; Cabral, Joaquim; Azevedo, Ana; Silva, Cláudia. "Scaling-up the manufacturing of well- characyerized mesenchumal stromal cell-derived extracellular vesicles for biomedical applications". Paper presented in International Society for Extracellular Vesicles Meeting 2020 (Virtual), Philadelphia, 2020.
  8. Pereira, M.J.C.; Ramalhete, Luís; Aleixo, Sandra; Lobato da Silva, C.; Cabral, Joaquim M. S.; Calado, C.R.C.; Fernandes-Platzgummer, Ana. "Evaluating the impact of culture conditions on human mesenchymal stem/stromal cell derived exosomes through FTIR microscopy". Paper presented in 24th Engineering Society for Animal Cell Technology 2019, Copenhaga, 2019.
  9. Pereira, M.J.C.; Ramalhete, Luís; Aleixo, Sandra; Lobato da Silva, C.; Cabral, Joaquim M. S.; Calado, C.R.C.; Fernandes-Platzgummer, Ana. "Evaluating the impact of culture conditions on human mesenchymal stem/stromal cell derived exosomes through FTIR microscopy". Paper presented in Advancing Manufacture of Cell and Gene Therapies VI, San Diego, 2019.
  10. Pereira, M.J.C.; Ramalhete, Luís; Aleixo, Sandra; Lobato da Silva, C.; Cabral, Joaquim M. S.; Calado, C.R.C.; Fernandes-Platzgummer, Ana. "Evaluating the impact of culture conditions on human mesenchymal stem/stromal cell derived exosomes through FTIR microscopy". Paper presented in 1st International Symposium Secretome without Borders, Braga, 2018.
  11. Fernandes-Platzgummer, Ana. "Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems". Paper presented in 1st Stem Cell Community Day, Hamburgo, 2017.
  12. Cabral, Joaquim M. S.; Diogo, Maria Margarida; Lobato da Silva, C.; Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Henrique, Domingos. "Optimization and Integration of the Expansion and Neural Commitment of Mouse Embryonic Stem Cells". Paper presented in 6th European Symposium on Biochemical Engineering Science, Salzgurg, 2016.
  13. Fernandes-Platzgummer, Ana; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems". Paper presented in Proteins and Antibody Engineering Summit, Lisboa, 2015.
  14. Fernandes-Platzgummer, Ana; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems". Paper presented in 9th International Meeting of the Portuguese Society for Stem Cells, Oeiras, 2015.
  15. Fernandes-Platzgummer, Ana; Carmelo, J.G.; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems". Paper presented in Scale-Up and Manufacturing of Cell-Based Therapies IV, San Diego, 2015.
  16. Carmelo, J.G.; Fernandes-Platzgummer, Ana; Weber, J.L.; Bear, M.; Hevy, M.; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems". Paper presented in 10th European Symposium on Biochemical Engineering Sciences and the 6th International Forum on Industrial Bioprocesses, Lille, 2014.
  17. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scale-up of mouse embryonic stem cell expansion: from spinner-flask to a fully controlled bioreactor". Paper presented in 8th ESBES-European Symposium on Biochemical Engineering Science, Bolonha, 2010.
  18. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Baptista, Ricardo; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scale-up of Mouse Embryonic Stem Cell Expansion: From Spinner-Flask to a Fully Controlled Bioreactor". Paper presented in IV International Meeting of the Portuguese Society of Stem Cells and Celular Therapy, Lisboa, 2009.
  19. Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Diogo, Maria Margarida; Lobato da Silva, C.; Henrique, Domingos; Dordick, J.S.; Cabral, Joaquim M. S.. "Micro-scale and Bioreactor Systems for the Expansion of mouse embryonic stem (mES) cells". Paper presented in CHEMPOR 2008: 10th International Chemical and Biological Engineering Conference, Braga, 2008.
  20. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Lobato da Silva, C.; Henrique, Domingos; Cabral, Joaquim M. S.. "Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system". Paper presented in Tissue Engineering and Regenerative Medicine International Society, 2008 Annual TERMIS - EU Meeting, Porto, 2008.
  21. Diogo, Maria Margarida; Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Lobato da Silva, C.; Henrique, Domingos; Cabral, Joaquim M. S.. "Large-scale and nano-scale approaches for the expansion of mouse embryonic stem (mES) cells". Paper presented in Third International Meeting of SPCE-TC, Faro, 2008.
  22. Fernandes-Platzgummer, Ana; Eibes, Gemma; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Modeling of mouse embryonic stem cell expansion in a strirred culture system". Paper presented in III International Meeting of the Portuguese Society of Stem Cells and Celular Therapy, Faro, 2008.
  23. Diogo, Maria Margarida; Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Lobato da Silva, C.; Henrique, Domingos; Cabral, Joaquim M. S.. "Optimization of expansion and neural commitment of mouse embryonic stem cells". Paper presented in MicroBiotecXXXIII JPG 2007, Lisboa, 2007.
  24. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scale-up of Mouse Embryonic Stem Cell Expansion in a stirred culture system". Paper presented in II International Meeting of the Portuguese Society of Stem Cells and Celular Therapy, Coimbra, 2007.
Conference paper
  1. Morini, Sara; Ulpiano, Cristiana; Cabral, Joaquim; Silva, Cláudia; Baptista, Pedro; Fernandes-Platzgummer, Ana. "Large-scale expansion and characterization of non-parenchymal cells towards the bioengineering of a porcine whole liver". Paper presented in ESACT-UK Virtual Conference, 2021.
  2. Canha Pereira, Maria Joao; Ramalhete, Luis; Aleixo, Sandra; da Silva, Claudia Lobato; Cabral, Joaquim M. S.; Calado, Cecilia R. C.; Fernandes-Platzgummer, Ana. "Impact of the human mesenchymal stem cells donor on conditional medium composition". 2019.
    10.1109/enbeng.2019.8692511
  3. Rosa, Filipa O.P.; Cunha, Bernardo; Carmelo, Joana G.; Fernandes-Platzgummer, Ana; da Silva, Claudia L.; Calado, Cecilia R. C.. "Mid-infrared spectroscopy: A groundbreaking tool for monitoring mammalian cells processes". Paper presented in 2017 Ieee 5th Portuguese Meeting on Bioengineering (Enbeng), 2017.
    10.1109/enbeng.2017.7889479
  4. Fernandes, Tiago G.; Diogo, Maria Margarida; Fernandes-Platzgummer, Ana; da Silva, Claudia Lobato; Cabral, Joaquim M. S.. "Effect of hypoxia on proliferation and neural commitment of embryonic stem cells at different stages of pluripotency". 2011.
    10.1109/enbeng.2011.6026039
Conference poster
  1. Doutor, Isabel; Fernandes-Platzgummer, Ana. "Optimizing the ex vivo expansion of umbilical cord blood natural killer cells and derived extracellular vesicle production under static conditions". Paper presented in XLVIII Annual Meeting Portuguese Society for Immunology, 2023.
  2. Doutor, Isabel; Branco, André; Fonte, Pedro; Fernandes-Platzgummer, Ana. "Optimization of the Ex Vivo Expansion of Umbilical Cord Blood Natural Killer Cells and Production of Derived Extracellular Vesicles Under Static Conditions". 2023.
  3. Doutor, Isabel; Fernandes-Platzgummer, Ana. "Optimization of ex vivo umbilical cord blood-derived natural killer cell expansion and production of derived extracellular vesicles under static conditions". 2022.
  4. Doutor, Isabel; Fernandes-Platzgummer, Ana. "Optimization of the ex-vivo expansion of umbilical cord blood-derived natural killer cells and production of their derived extracellular vesicles under static conditions". 2022.
  5. Morini, Sara; Ulpiano, Cristiana; Cabral, Joaquim; Silva, Cláudia; Baptista, Pedro; Fernandes-Platzgummer, Ana. "Biomanufacturing platform development for the large-scale production of non-parenchymal cells towards the bioengineering of a porcine whole liver". Paper presented in 13th IBEC Symposium - Bioengineering for Future and Precision Medicine, 2020.
  6. Fuzeta, Miguel de Almeida ; Fernandes-Platzgummer, Ana; Bernardes, Nuno; Cabral, Joaquim; da Silva, Claudia Lobato. "Manufacturing Extracellular Vesicles Derived from Human Mesenchymal Stromal Cells (MSC) in Bioreactors for Cancer Therapy". Paper presented in International Society for Extracellular Vesicles Meeting 2020. Philadelphia, Pennsylvania, USA., 2020.
  7. Fernandes-Platzgummer, Ana; Ramalhete, Luis; Aleixo, Sandra; Silva, Cláudia; Cabral, Joaquim; Calado, Cecília Ribeiro da Cruz. "Evaluating the impact of culture conditions on human mesenchymal stromal cell-derived extracellular vesicles molecular fingerprint through FTIR spectroscopy". Paper presented in International Society for Extracellular Vesicles Meeting 2020. Philadelphia, Pennsylvania, USA, 2020.
  8. Silva, Ricardo M.; Rosa, Sara; Silva, Cláudia; Fernandes-Platzgummer, Ana; Azevedo, Ana. "A chromatography approach for clinical-grade purification of MSC-derived extracellular vesicles". Paper presented in Microbiotec 2019, Coimbra, Portugal, 2019.
  9. Pereira, M.J.C.; Ramalhete, Luís; Aleixo, Sandra; Lobato da Silva, C.; Cabral, Joaquim M. S.; Calado, CRC; Fernandes-Platzgummer, Ana. "Evaluating the impact of culture conditions on human mesenchymal stem/stromal cell derived exosomes through FTIR microscopy". Paper presented in Engineering Society for Animal Cell Technology 2019, Copenhagen, Denmark, 2019.
  10. Pereira, M.J.C.; Ramalhete, Luís; Aleixo, Sandra; Lobato da Silva, C.; Cabral, Joaquim M. S.; Calado, C.R.C.; Fernandes-Platzgummer, Ana. "Evaluating the Impact of Culture Conditions on Mesenchymal Stem/Stromal Cell-derived Extracellular Vesicles Through FTIR Spectroscopy". Paper presented in 6th IEEE Portuguese meeting in Bioengineering, Lisboa, Portugal, 2019.
  11. de Matos Branco, André Dargen; Bucar, Sara; Lilaia, C.; Cabral, Joaquim M. S.; Fernandes-Platzgummer, Ana; Lobato da Silva, C.. "Cytokine Optimization for Ex Vivo Expansion of Hematopoietic Stem/Progenitor cells in a Mesenchymal Stem/Stromal Cell Co-Culture System". Paper presented in 6th IEEE Portuguese meeting in Bioengineering, Lisboa, Portugal, 2019.
  12. Borges, A.S.G.; Fernandes, Tiago Baptista; Lobato da Silva, C.; Fernandes-Platzgummer, Ana. "Isolation and Characterization of Diferente Cell Types from Lipoaspirates Used for Treating Alopecia". Paper presented in Annual International (bio) Medical Students Meeting, Lisboa, Portugal, 2019.
  13. Fernandes-Platzgummer, Ana; Pinto, Diogo S.; de Almeida Fuzeta, Miguel; Rodrigues, Carlos A.V.; Bernardes, Nuno; Jung, S-H; Tseng, R-J; et al. "Scalable expansion of human umbilical cord matrix- and adipose tissue-derived mesenchymal stem/stromal cells and derived exosomes in the single-use, vertical wheel bioreactor system using a human platelet lysate culture supplement". Paper presented in Advancing Manufacture of Cell and Gene Therapies VI, San Diego, USA, 2019.
  14. de Almeida Fuzeta, Miguel; Pinto, Diogo S.; Oliveira, Filipa D.; Rodrigues, Carlos A.V.; Fernandes-Platzgummer, Ana; Jung, S-H; Lee, Brian; et al. "Manufacturing Human Mesenchymal Stem/stromal Cells (MSC) and MSC-derived Extracellular Vesicles in Vertical-Wheel Bioreactors". Paper presented in 1st International Symposium Secretome without Borders, Braga, Portugal, 2018.
  15. Fernandes-Platzgummer, Ana; de Soure, A.M.; Huang, Y.-F.; Miligan, W.; Mizukami, Amanda; Swiech, Kamilla; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Umbilical cord matrix derived-mesenchymal stem/stromal cell production in microcarrier-based culture systems". Paper presented in Scale-up and Manufacturing of Cell-Based Therapies IV, San Diego, CA USA, 2017.
  16. Fernandes-Platzgummer, Ana; de Soure, A.M.; Moreira, F.; Lilaia, C.; Liu, S-H; Ku, C-P; Huang, Y-F; et al. "A human platelet lysate-based culture supplement for the sucssful isolation and scalable expansion of umbilical cord matrix-derived mesenchymal stem/stromal cells". Paper presented in Bioprocessing of Advanced Cellular Therapies Congress , London, UK, 2016.
  17. Fernandes-Platzgummer, Ana; Carmelo, J.G.; de Soure, A.M.; Moreira, F.; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scalable production of human mesenchymal stem/stromal cells from different human sources in microcarrier-based stirred culture systems". Paper presented in Cell Culture Engineering XV, Palm Springs, USA, 2016.
  18. Fernandes-Platzgummer, Ana; Mata, M.F.; Loper, J.P.; Cabral, Joaquim M. S.; Lobato da Silva, C.. "Bioengineering approaches for the ex vivo expansion and angiogenic fortification of human CD34+ progenitor cells". Paper presented in 2nd International Advanced Course on Regenerative Medicine Manufacturing, South Caroline, USA, 2016.
  19. Fernandes-Platzgummer, Ana; Carmelo, Joana G.; Weber, J.L.; Bear, M.; Hevy, M.; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scalable production of human mesenchymal stem/stromal cells in microcarrier-based culture systems". Paper presented in 4th International Conference on Stem Cell Engineering, San Diego, CA USA, 2014.
  20. Lobato da Silva, C.; Carmelo, J.G.; Fernandes-Platzgummer, Ana; Weber, J.L.; Bear, M.; Hevy, M.; Diogo, Maria Margarida; Cabral, Joaquim M. S.. "Evaluation of microcarrier-based suspension cultures for human mesenchymal stem cells". Paper presented in Scale-up and Manufacturing of Cell-Based Therapies III, San Diego, CA USA, 2014.
  21. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Optimized Operation of a Stirred Tank Bioreactor Towards the Controlled Production of Mouse Embryonic Stem Cells". Paper presented in International Advanced Course on Regenerative Medicine Manufacturing, Portugal, 2013.
  22. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Optimized Operation of a Stirred Tank Bioreactor Towards the Controlled Production of Mouse Embryonic Stem Cells". Paper presented in 9th European Symposium on Biochemical Engineering Science (ESBES), Turkey, 2012.
  23. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Production of mouse embryonic stem cells in a stirred bioreactor". Paper presented in ESACT- European Society of Animal Cell Technology, Vienna, Austria, 2011.
  24. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scaleup of mouse embryonic stem cell expansion: from spinner-flask to a fully controlled bioreactor". Paper presented in SBE- Stem CellEngineering Conference, Boston, USA, 2010.
  25. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Baptista, Ricardo; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scale-up of Mouse Embryonic Stem Cell Expansion: From Spinner-Flask to a Fully Controlled Bioreactor". Paper presented in 7th Annual Meeting of the international Society for Stem Cell Research, Spain, 2009.
  26. Fernandes-Platzgummer, Ana; Fernandes, Tiago G.; Diogo, Maria Margarida; Lobato da Silva, C.; Dordick, J.S.; Cabral, Joaquim M. S.. "Effects of low oxygen tension on mouse embryonic stem cell expansion". Paper presented in 7th ISSCR Annual Meeting, Barcelona, Spain, 2009.
  27. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Baptista, Ricardo; Lobato da Silva, C.; Cabral, Joaquim M. S.. "Scale-up of Mouse Embryonic Stem Cell Expansion: From Spinner-Flask to a Fully Controlled Bioreactor". Paper presented in 7th Annual Meeting of the international Society for Stem Cell Research, 2009.
  28. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; Lobato da Silva, C.; Henrique, Domingos; Cabral, Joaquim M. S.. "Mouse Embryonic Stem Cell Expansion in a Microcarrier-Based Stirred Culture System". Paper presented in SBE´s First International Conference on Stem Cell Engineering, Coronado Island, USA, 2008.
  29. Fernandes-Platzgummer, Ana; Diogo, Maria Margarida; lobato, cláudia; Henrique, Domingos; Cabral, Joaquim M. S.. "Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system". Paper presented in MICRO´07-BIOTEC´07-XXXIII JPG, 2007.
  30. da Silva, Cláudia Lobato; Andrade, Pedro; dos Santos, Francisco; Fernandes-Platzgummer, Ana; Porada, Graça; Cabral, Joaquim M. S.. "Expansion of human adult bone marrow mesenchymal stem cells using gelatin microcarriers under dynamic culture conditions". Paper presented in 36th Annual Scientific Meeting - ISEH Society for Hematology and Stem Cells, 2007.
Journal article
  1. Fernandes-Platzgummer, Ana; Cunha, Raquel; Morini, Sara; Joaquim M.S. Cabral; da Silva, Claudia Lobato. Corresponding author: Fernandes-Platzgummer, Ana. "Optimized operation of a controlled stirred tank reactor system for the production of mesenchymal stromal cells and their extracellular vesicles". Bioengineering and Biotechnology (2023):
    Accepted
  2. Marques, Cláudia Raquel; Fuzeta, Miguel de Almeida; dos Santos Cunha, Raquel Medina; Pereira-Sousa, Joana; Silva, Deolinda; Campos, Jonas; Teixeira-Castro, Andreia; et al. "Neurodifferentiation and Neuroprotection Potential of Mesenchymal Stromal Cell-Derived Secretome Produced in Different Dynamic Systems". Biomedicines 11 5 (2023): 1240. http://dx.doi.org/10.3390/biomedicines11051240.
    10.3390/biomedicines11051240
  3. Silva, Ricardo M.; Rosa, Sara Sousa; Cunha, Raquel; L. da Silva, Cláudia; Azevedo, Ana M.; Fernandes-Platzgummer, Ana. "Anion exchange chromatography-based platform for the scalable purification of extracellular vesicles derived from human mesenchymal stromal cells". Separation and Purification Technology 310 (2023): 123238. http://dx.doi.org/10.1016/j.seppur.2023.123238.
    10.1016/j.seppur.2023.123238
  4. Branco, André; Tiago, Ana L.; Laranjeira, Paula; Carreira, Maria C.; Milhano, João C.; dos Santos, Francisco; Cabral, Joaquim M. S.; et al. "Hypothermic Preservation of Adipose-Derived Mesenchymal Stromal Cells as a Viable Solution for the Storage and Distribution of Cell Therapy Products". Bioengineering 9 12 (2022): 805. http://dx.doi.org/10.3390/bioengineering9120805.
    10.3390/bioengineering9120805
  5. de Almeida Fuzeta, Miguel; Gonçalves, Pedro P.; Fernandes-Platzgummer, Ana; Cabral, Joaquim M. S.; Bernardes, Nuno; da Silva, Cláudia L.. "From Promise to Reality: Bioengineering Strategies to Enhance the Therapeutic Potential of Extracellular Vesicles". Bioengineering 9 11 (2022): 675. http://dx.doi.org/10.3390/bioengineering9110675.
    10.3390/bioengineering9110675
  6. Bucar, Sara; Branco, André Dargen de Matos; Mata, Márcia F.; Milhano, João Coutinho; Caramalho, Íris; Cabral, Joaquim M. S.; Fernandes-Platzgummer, Ana; da Silva, Cláudia L.. "Influence of the mesenchymal stromal cell source on the hematopoietic supportive capacity of umbilical cord blood-derived CD34+-enriched cells". Stem Cell Research & Therapy 12 1 (2021): http://dx.doi.org/10.1186/s13287-021-02474-8.
    10.1186/s13287-021-02474-8
  7. Cunha, R.; Calado, C.; Cabral, J.M.; da Silva, C.L.; Fernandes-Platzgummer, A.. "Towards improved large-scale manufacturing processes of mesenchymal stromal cell-derived extracellular vesicles". Cytotherapy 23 5 (2021): S116. http://dx.doi.org/10.1016/s1465324921004606.
    Published • 10.1016/s1465324921004606
  8. Cunha, Raquel; Calado, Cecília Ribeiro da Cruz ; Cabral, Joaquim; Silva, Cláudia; Fernandes-Platzgummer, Ana. "Optimization of culture conditions for the production of mesenchymal stromal cell-derived extracellular vesicles towards its translation into large-scale manufacturing (PS08.01.) - ISEV2021 Abstract Book". Journal of Extracellular Vesicles 10 S1 (2021): http://dx.doi.org/10.1002/jev2.12083.
    Published • 10.1002/jev2.12083
  9. Fuzeta, Miguel de Almeida ; Bernardes, Nuno; Simonides Immanuel van de van de Wakker; Marieke T. T. Roefs; Wilte Olijve; Fernandes-Platzgummer, Ana; Pieter Vader; et al. "Scalable bioreactor production and angiogenic potential of extracellular vesicles derived from human mesenchymal stromal cells (PS09.07.)- ISEV2021 Abstract Book". Journal of Extracellular Vesicles 10 S1 (2021): http://dx.doi.org/10.1002/jev2.12083.
    Published • 10.1002/jev2.12083
  10. de Almeida Fuzeta, Miguel; Bernardes, Nuno; Oliveira, Filipa D.; Costa, Ana Catarina; Fernandes-Platzgummer, Ana; Farinha, José Paulo; Rodrigues, Carlos A. V.; et al. "Scalable Production of Human Mesenchymal Stromal Cell-Derived Extracellular Vesicles Under Serum-/Xeno-Free Conditions in a Microcarrier-Based Bioreactor Culture System". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.553444.
    10.3389/fcell.2020.553444
  11. Branco, André; Bucar, Sara; Moura-Sampaio, Jorge; Lilaia, Carla; Cabral, Joaquim M. S.; Fernandes-Platzgummer, Ana; Lobato da Silva, Cláudia. "Tailored Cytokine Optimization for ex vivo Culture Platforms Targeting the Expansion of Human Hematopoietic Stem/Progenitor Cells". Frontiers in Bioengineering and Biotechnology 8 (2020): http://dx.doi.org/10.3389/fbioe.2020.573282.
    10.3389/fbioe.2020.573282
  12. Fernandes-Platzgummer, A.; Rosa, S.S.; Silva, R.; Cunha, R.; Fuzeta, M.A.; Calado, C.; Carvalho, C.; et al. "Design and operation of a fully controlled platform for the production and purification of well-defined mesenchymal stromal cell (MSC)-derived extracellular vesicles". Cytotherapy 22 5 (2020): S48-S49. http://dx.doi.org/10.1016/j.jcyt.2020.03.058.
    10.1016/j.jcyt.2020.03.058
  13. Fuzeta, M.A.; Oliveira, F.D; Costa, A.C.; Fernandes-Platzgummer, A.; Jung, S.; Tseng, R.; Milligan, W.; et al. "Scalable Production of Human Mesenchymal Stromal Cell (MSC)-Derived Extracellular Vesicles in Microcarrier-based Bioreactors under Xeno(geneic)-free Conditions". Cytotherapy 22 5 (2020): S23-S24. http://dx.doi.org/10.1016/j.jcyt.2020.03.499.
    10.1016/j.jcyt.2020.03.499
  14. Azevedo, Rita I.; Minskaia, Ekaterina; Fernandes-Platzgummer, Ana; Vieira, Ana I. S.; da Silva, Cláudia L.; Cabral, Joaquim M. S.; Lacerda, João F.. "Mesenchymal stromal cells induce regulatory T cells via epigenetic conversion of human conventional CD4 T cells in vitro". STEM CELLS 38 8 (2020): 1007-1019. http://dx.doi.org/10.1002/stem.3185.
    10.1002/stem.3185
  15. Pinto DS; Ahsan T; Serra J; Fernandes-Platzgummer A; Cabral JMS; da Silva CL. "Modulation of the in vitro angiogenic potential of human mesenchymal stromal cells from different tissue sources.". Journal of cellular physiology (2020): http://europepmc.org/abstract/med/32037550.
    Published • 10.1002/jcp.29622
  16. Pushp, Pallavi; Sahoo, Bijayalaxmi; Ferreira, Frederico C.; Sampaio Cabral, Joaquim M.; Fernandes-Platzgummer, Ana; Gupta, Mukesh K.. "Functional comparison of beating cardiomyocytes differentiated from umbilical cord-derived mesenchymal/stromal stem cells and human foreskin-derived induced pluripotent stem cells". Journal of Biomedical Materials Research Part A 108 3 (2019): 496-514. http://dx.doi.org/10.1002/jbm.a.36831.
    10.1002/jbm.a.36831
  17. Azevedo, Rita I; Minskaia, Ekaterina; Lobato da Silva, Cláudia; Fernandes Platzgummer, Ana; Vieira, Ana I.S.; Cabral, Joaquim M.S.; Lacerda, Joao F. "Epigenetic Profile of Treg-like Cells Induced By Mesenchymal Stem Cells in Vitro Resembles That of Natural Treg". Blood 132 Supplement (2018): 2578-2578. http://dx.doi.org/10.1182/blood-2018-99-112452.
    10.1182/blood-2018-99-112452
  18. Mizukami, Amanda; de Abreu Neto, Mario Soares; Moreira, Francisco; Fernandes-Platzgummer, Ana; Huang, Yi-Feng; Milligan, William; Cabral, Joaquim M. S.; et al. "A Fully-Closed and Automated Hollow Fiber Bioreactor for Clinical-Grade Manufacturing of Human Mesenchymal Stem/Stromal Cells". Stem Cell Reviews and Reports 14 1 (2018): 141-143. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000424277300012&KeyUID=WOS:000424277300012.
    10.1007/s12015-017-9787-4
  19. Mizukami, A.; Neto, M.S.; Moreira, F.; Fernandes-Platzgummer, A.; Huang, Y.; Milligan, W.; Cabral, J.M.; et al. "Efficient clinical-scale expansion of adipose tissue-derived mesenchymal stem/stromal cells in a closed and automated hollow-fiber bioreactor under xeno-free culture conditions". Cytotherapy 19 5 (2017): S154. http://dx.doi.org/10.1016/j.jcyt.2017.02.231.
    10.1016/j.jcyt.2017.02.231
  20. Azevedo, Rita; Minskaia, Ekaterina; Lobato da Silva, C.; Fernandes-Platzgummer, Ana; Vieira, A.I.S.; Cabral, Joaquim M.S.; Lacerda, Joao F. "Mechanisms of Regulatory T Cell Recruitment By Mesenchymal Stem Cells in Vitro". Blood 130 Supplement (2017): 1161-1161. https://ashpublications.org/blood/article/130/Supplement%201/1161/116378/Mechanisms-of-Regulatory-T-Cell-Recruitment-By.
    Published
  21. Source, A.; Fernandes-Platzgummer, A.; Moreira, F.; Liu, S.; Ku, C.; Huang, Y.; Milligan, W.; Cabral, J.S.; da Silva, C.L.. "A Human Platelet Lysate-Based Culture Supplement for the Successful Isolation and Scalable Expansion of umbilical Cord Matrix-Derived Mesenchymal Stem/Stromal Cells". Cytotherapy 18 6 (2016): S129. http://dx.doi.org/10.1016/j.jcyt.2016.03.246.
    10.1016/j.jcyt.2016.03.246
  22. de Soure, A.M.; Fernandes-Platzgummer, A.; da Silva, C.L.; Cabral, J.M.S.. "Scalable microcarrier-based manufacturing of mesenchymal stem/stromal cells". Journal of Biotechnology 236 (2016): 88-109. http://www.scopus.com/inward/record.url?eid=2-s2.0-84983744590&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2016.08.007
  23. Mizukami, A.; Fernandes-Platzgummer, A.; Carmelo, J.G.; Swiech, K.; Covas, D.T.; Cabral, J.M.S.; da Silva, C.L.. "Stirred tank bioreactor culture combined with serum-/xenogeneic-free culture medium enables an efficient expansion of umbilical cord-derived mesenchymal stem/stromal cells". Biotechnology Journal 11 8 (2016): 1048-1059. http://www.scopus.com/inward/record.url?eid=2-s2.0-84979769173&partnerID=MN8TOARS.
    10.1002/biot.201500532
  24. Rosa, F.; Sales, K.C.; Carmelo, J.G.; Fernandes-Platzgummer, A.; da Silva, C.L.; Lopes, M.B.; Calado, C.R.C.. "Monitoring the ex-vivo expansion of human mesenchymal stem/stromal cells in xeno-free microcarrier-based reactor systems by MIR spectroscopy". Biotechnology Progress 32 2 (2016): 447-455. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976240523&partnerID=MN8TOARS.
    10.1002/btpr.2215
  25. Almeida, A.R.; Correia, D.V.; Fernandes-Platzgummer, A.; Da Silva, C.L.; Da Silva, M.G.; Anjos, D.R.; Silva-Santos, B.. "Delta one T cells for immunotherapy of chronic lymphocytic leukemia: Clinical-grade expansion/differentiation and preclinical proof of concept". Clinical Cancer Research 22 23 (2016): 5795-5804. http://www.scopus.com/inward/record.url?eid=2-s2.0-85006276843&partnerID=MN8TOARS.
    10.1158/1078-0432.CCR-16-0597
  26. de Soure, A.M.; Fernandes-Platzgummer, A.; Moreira, F.; Lilaia, C.; Liu, S.-H.; Ku, C.-P.; Huang, Y.-F.; et al. "Integrated culture platform based on a human platelet lysate supplement for the isolation and scalable manufacturing of umbilical cord matrix-derived mesenchymal stem/stromal cells". Journal of Tissue Engineering and Regenerative Medicine (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84978971078&partnerID=MN8TOARS.
    10.1002/term.2200
  27. Soure, António M.; Fernandes-Platzgummer, Ana; Moreira, Francisco; Liu, Shi-Hwei; Ku, Chen-Peng; Huang, Yi-Feng; Milligan, William; Cabral, Joaquim S.; da Silva, Claudia L.. "A human platelet lysate-based culture supplement for the successful isolation and scalable expansion of umbilical cord matrix-derived mesenchymal stem/stromal cells". Cytotherapy 17 6 (2015): S43. http://dx.doi.org/10.1016/j.jcyt.2015.03.455.
    10.1016/j.jcyt.2015.03.455
  28. Carmelo, J.G.; Fernandes-Platzgummer, A.; Diogo, M.M.; da Silva, C.L.; Cabral, J.M.S.. "A xeno-free microcarrier-based stirred culture system for the scalable expansion of human mesenchymal stem/stromal cells isolated from bone marrow and adipose tissue". Biotechnology Journal 10 8 (2015): 1235-1247. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938992877&partnerID=MN8TOARS.
    10.1002/biot.201400586
  29. da Silva, C.L.; Carmelo, J.G.; Fernandes-Platzgummer, A.; Weber, J.L.; Bear, M.; Hervy, M.; Diogo, M.M.; Cabral, J.S.. "Scalable production of human mesenchymal stem/stromal cells in microcarrier-based culture systems". Cytotherapy 16 4 (2014): S101-S102. http://dx.doi.org/10.1016/j.jcyt.2014.01.377.
    10.1016/j.jcyt.2014.01.377
  30. Fernandes-Platzgummer, A.; Diogo, M.M.; Lobato da Silva, C.; Cabral, J.M.S.. "Maximizing mouse embryonic stem cell production in a stirred tank reactor by controlling dissolved oxygen concentration and continuous perfusion operation". Biochemical Engineering Journal 82 (2014): 81-90. http://www.scopus.com/inward/record.url?eid=2-s2.0-84889596268&partnerID=MN8TOARS.
    10.1016/j.bej.2013.11.014
  31. Dos Santos, F.; Campbell, A.; Fernandes-Platzgummer, A.; Andrade, P.Z.; Gimble, J.M.; Wen, Y.; Boucher, S.; et al. "A xenogeneic-free bioreactor system for the clinical-scale expansion of human mesenchymal stem/stromal cells". Biotechnology and Bioengineering 111 6 (2014): 1116-1127. http://www.scopus.com/inward/record.url?eid=2-s2.0-84899649027&partnerID=MN8TOARS.
    10.1002/bit.25187
  32. Silva, M.F.F.; Fernandes-Platzgummer, A.; Aires-Barros, M.R.; Azevedo, A.M.. "Integrated purification of monoclonal antibodies directly from cell culture medium with aqueous two-phase systems". Separation and Purification Technology 132 (2014): 330-335. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902685625&partnerID=MN8TOARS.
    10.1016/j.seppur.2014.05.041
  33. Fernandes-Platzgummer, A.; Diogo, M.M.; Baptista, R.P.; Silva, C.L.D.; Cabral, J.M.. "Scale-up of mouse embryonic stem cell expansion in stirred bioreactors". Biotechnology Progress 27 5 (2011): 1421-1432. http://www.scopus.com/inward/record.url?eid=2-s2.0-80053909366&partnerID=MN8TOARS.
    10.1002/btpr.658
  34. Fernandes, T.G.; Diogo, M.M.; Fernandes-Platzgummer, A.; da Silva, C.L.; Cabral, J.M.S.. "Different stages of pluripotency determine distinct patterns of proliferation, metabolism, and lineage commitment of embryonic stem cells under hypoxia". Stem Cell Research 5 1 (2010): 76-89. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953286613&partnerID=MN8TOARS.
    10.1016/j.scr.2010.04.003
  35. Fernandes, T.G.; Fernandes-Platzgummer, A.M.; da Silva, C.L.; Diogo, M.M.; Cabral, J.M.S.. "Kinetic and metabolic analysis of mouse embryonic stem cell expansion under serum-free conditions". Biotechnology Letters 32 1 (2009): 171-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-72249097517&partnerID=MN8TOARS.
    10.1007/s10529-009-0108-0
  36. Fernandes, A.M.; Fernandes, T.G.; Diogo, M.M.; da Silva, C.L.; Henrique, D.; Cabral, J.M.S.. "Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system". Journal of Biotechnology 132 2 (2007): 227-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-35348996645&partnerID=MN8TOARS.
    10.1016/j.jbiotec.2007.05.031
Thesis / Dissertation
  1. Fernandes-Platzgummer, Ana. "Bioreactor culture systems for the expansion of mouse embryonic stem cells". PhD, Universidade de Lisboa Instituto Superior Técnico, 2011.
  2. Fernandes-Platzgummer, Ana. "Scale-up of mouse embryonic stem cell expansion in a stirred culture system". Master, Universidade de Lisboa Instituto Superior Técnico, 2007.
  3. Fernandes-Platzgummer, Ana. "Cloning of human targets in eucaryotic expression vectors and generation of serum free transfectants in mammalian cell culture". Degree, Universität für Bodenkultur Wien, 2005.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2020/05 Scaling-up the manufacturing of well-characyerized mesenchumal stromal cell-derived extracellular vesicles for biomedical applications International Society for Extracellular Vesicles Meeting 2020 (Virtual)
International Society for Extracellular Vesicles (Philadelphia, United States)
2019/05 Evaluating the impact of culture conditions on human mesenchymal stem/stromal cell derived exosomes through FTIR microscopy" 24th Engineering Society for Animal Cell Technology 2019
Engineering Society for Animal Cell Technology (Copenhaga, Denmark)
2019/01 Evaluating the impact of culture conditions on human mesenchymal stem/stromal cell derived exosomes through FTIR microscopy Advancing Manufacture of Cell and Gene Therapies VI
ECI (San Diego, United States)
2018/12/05 Manufacturing Challenges in Cellular therapies Master course
Faculdade de Farmácia da Universidade de Lisboa
2018 "Evaluating the impact of culture conditions on human mesenchymal stem/stromal cell derived exosomes through FTIR microscopy 1st International Symposium Secretome without Borders
University of Minho (Braga, Portugal)
2017 Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems 1st Stem Cell Community Day
Eppendorf (Hamburg, Germany)
2016/01/01 Scalable production of human stem cells in bioreactors Advance course "Stem Cells get practical- Approaches on stem cells isolation, characterization and differentiation"
University of Minho (Portugal)
2015/01 Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems Scale-Up and Manufacturing of Cell-Based Therapies IV
ECI (San Diego, United States)
2015 Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems 9th International Meeting of the Portuguese Society for Stem Cells
Portuguese Society for Stem Cells (Oeiras, Portugal)
2014/11 Scalable production of human mesenchymal stem/stromal cells in microcarrier-based stirred culture systems 6th Proteins and Antibody Engineering Summit (PEGS)
Cambridge Healthtech Institute (CHI) (Lisboa, Portugal)
2010/09 Scale-up of mouse embryonic stem cell expansion: from spinner-flask to a fully controlled bioreactor 8th ESBES European Symposium on Biochemical Engineering Science
European Symposium on Biochemical Engineering Science (Bologne, Italy)
2009 Scale-up of Mouse Embryonic Stem Cell Expansion: From Spinner-Flask to a Fully Controlled Bioreactor IV International Meeting of the Portuguese Society of Stem Cells and Celular Therapy
Portuguese Society of Stem Cells and Celular Therapy (Lisboa, Portugal)
2008 Mouse embryonic stem cell expansion in a microcarrier-based stirred culture system Tissue Engineering and Regenerative Medicine International Society (TERMIS) 2008
Tissue Engineering and Regenerative Medicine International Society (Porto, Portugal)
2008 Modeling of mouse embryonic stem cell expansion in a strirred culture system III International Meeting of the Portuguese Society of Stem Cells and Celular Therapy
Portuguese Society of Stem Cells and Celular Therapy (Faro, Portugal)
2007/03/21 Scale-up of Mouse Embryonic Stem Cell Expansion in a stirred culture system International Courses on Toxicology 2007
Center for Neurosciences and Cell Biology, University of Coimbra (Coimbra, Portugal)
2007 Scale-up of Mouse Embryonic Stem Cell Expansion in a stirred culture system II International Meeting of the Portuguese Society of Stem Cells and Celular Therapy
Portuguese Society of Stem Cells and Celular Therapy (Coimbra, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/01/01 - Current Biomeat - Manufacturing cultured meat through a scalable and cost-effective bioprocess
Supervisor
Universidade de Lisboa Instituto Superior Técnico, Portugal
2023/01/01 - Current GMP-compliant manufacturing of mesenchymal stromal cells-derived extracellular vesicles with immunomodulatory potential
Supervisor
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/04/05 - Current Technology-driven platform for the manufacturing of extracellular vesicles derived from umbilical cord blood CAR-engineered NK cells for immunotherapy
Supervisor
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/02/01 - Current Design and operation of a prototype bioreactor for the expansion and in situ selection of human hematopoietic stem/progenitor cells
Supervisor of André Dargen de Matos Branco
 Bioengenharia (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09/01 - 2022/12 Establishment of functional assays to evaluate the therapeutic potential of mesenchymal stromal cell-derived products
Supervisor
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/09/01 - 2022/11 Optimization of hematopoietic Stem Cells/ Mesenchymal Stromal Cells Co-cultures
Supervisor
Associação do Instituto Superior Técnico para a Investigação e Desenvolvimento, Portugal
2021/09/01 - 2022/11 Delineation Of Optimal Culture Conditions For The Expansion And Differentiation Of Bovine Mesenchymal Stromal Cells
Supervisor
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/09/01 - 2021/11/01 Delineation of optimal culture conditions for therapeutic human mesenchymal stromal cell-derived extracellular vesicles (MSC-EVs) production in dynamic cultures
Supervisor
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/09/01 - 2021/11 Breaking Down Mesenchymal Stem/Stromal Cells: Uncovering the Potential of Decellularized Extracellular Matrix
Supervisor
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/02/01 - 2021/09/24 Biomanufacturing platform for the large-scale production of different stem/progenitor cells towards the bioengineering of a porcine whole-liver
Co-supervisor of Sara Morini
 Bioengenharia (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/02/01 - 2021/06 Development of scalable processes to produce therapeutic mesenchymal stromal cell-derived extracellular vesicles and their characterization
Supervisor of Raquel Medina Cunha
 Post-doctoral researcher hired through the project EXOpro (Other)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/02/01 - 2021/01/21 Evaluation and establishment of isolation and culture methodologies for mesenchymal stromal cells from umbilical cord matrix and adipose tissue towards the development of a cell therapy for autoimmune diseases
Supervisor of Ana Lúcia Bastos Tiago
 Engenharia Biomédica (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/09/01 - 2020/12/14 Development of a novel scalable downstream process, for the isolation and purification of a fully characterized mesenchymal stem/stromal cells-derived extracellular vesicles-based product
Supervisor of Ricardo Miguel medalha da Silva
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/09/01 - 2019/12 Study the Influence of the source of human mesenchymal stem/stromal cell on the molecular fingerprint of therapeutic extracellular vesicles, through FTIR spectroscopy
Co-supervisor of Filipa Pires
 Engenharia Biomédica (Master)
Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2019/02/01 - 2019/07/31 Evaluation of the angiogenic potential of conditioned media from cellular lines of mesenchymal stem cells derived from adipose tissue cultivated in a dynamic system
Supervisor of Elga Johanna Vargas,
Universidad Nacional de Colombia, Colombia
2017/01/06 - 2018 Isolation and Characterization of Different Cell Types from Lipoaspirates Used for Treating Alopecia
Supervisor of Ana Sofia Galrinho Borges
 Master in Biomedical Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/01/05 - 2017/12 Study the Influence of the culture conditions on therapeutic human mesenchymal stem/stromal cell-derived exosomes cargo through FTIR spectroscopy
Supervisor of Maria João Canha Pereira
 Master in Biologic Engineering (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/02/01 - 2017/04/30 Optimization of the mycoplasm detection protocol on stem cell cultures
Supervisor of Clara Maerk
Medizinische Universität Wien, Austria
2016/09/01 - 2016/12/15 Isolation and dynamic expansion of porcine mesenchymal stem/stromal cell from bone marrow
Supervisor of Sara Morini
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/02/05 - 2016/12/05 Decellularization and recellularization of porcine livers and design and construction of an automatic machine setup for liver perfusion decellularization
Supervisor of Manuel Larião de Almeida
 Engenharia Biológica (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - 2016/09/27 Ex-vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells
Supervisor of Jorge Moura Sampaio
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - 2016/09/27 Expansion of Adipose-derived Stem/Stromal Cells under dynamic culture conditions
Supervisor of Margarida Maria Pacheco Barroso
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - 2016/09/26 Integrated process for the production and purification of monoclonal antibodies from animal cell cultures
Co-supervisor of Nicholus Joab Mukhwana
 Biotecnologia (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - 2015/12/20 Quantification of Mesenchymal Stem/Stromal Cell Differentiation
Supervisor of Andreia Santos
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/02/01 - 2015/11/30 Ex-vivo expansion of umbilical cord-derived mesenchymal stem/stromal cells in a stirred-tank bioreactor using serum-xenogeneic-free culture medium
Supervisor of Amanda Mizukami
Universidade de São Paulo Câmpus de Ribeirão Preto, Brazil
2015/06/01 - 2015/07/31 Ex-vivo expansion of mesenchymal stem/stromal cells from human sources under xenogeneic-free culture conditions
Supervisor of Matilde Melo
Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/06/01 - 2015/07/31 Monitoring mesenchymal stem/stromal cell culture by the analysis of glucose and lactate metabolism
Supervisor of Daniel Pais
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/01/01 - 2015/01/31 Induction of Immune Tolerance in Human Allogeneic Hematopoietic Stem Cell Transplantation
Supervisor of Joana Carmelo
2013/07/01 - 2013/12/31 Production of human Mesenchymal Stem cells in bioreactor systems
Supervisor of Joana carmelo
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/05/01 - 2013/12/31 Production of human Mesenchymal Stem cells in bioreactor systems
Supervisor of Joana Serra
Universidade de Lisboa Instituto Superior Técnico, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2012/03/16 - 2012/03/17 3rd Scientific Meeting of Institute for Biotechnology and Bioengineering (2012/03/16 - 2012/03/17)
Meeting
 Instituto de Biotecnologia e Bioengenharia, Portugal
2008/09/01 - 2009/05/15 IV International Meeting of the Portuguese Society of Stem Cells and Celular Therapies (2009/04/29 - 2009/04/30)
Congress (Member of the Organising Committee)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2003 - 2003 Organization of the conference "Protein crystallography” as a student of Biological Engineering (2003 - 2003)
Conference (Co-organisor)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2002 - 2003 Organization of the 2nd Cycle of Biological Engineering Conferences (IST): 1st Conference “Anaerobic digestion process for the treatment of urban solid residues - Valorsul” and 2nd Conference “From Fly to Man- Basic Investigation in Portugal”. (2002 - 2003)
Conference (Co-organisor)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2002 - 2002 Organization of the 1st BioEmpresas (BioEnterprises), IST, to promote and strengthen the relationship between Enterprises and University; (2002 - 2002)
Conference (Co-organisor)
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2001 - 2002 Organization of the 1st Cycle of Biological Engineering Conferences (IST): 1st Conference “Present and Future of Biological Engineering in the Pharmaceutical Industry – An Enterpriser´s Perspective” and 2nd Conference “Present and Future of Biological Engineering in the Food Industry”; (2001 - 2002)
Conference (Co-organisor)
 Universidade de Lisboa Instituto Superior Técnico, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2021/10 - Current National initiative to celebrate the International Stem Cell Day, 4 seminars to more than 100 students between 15-18 years old.
Ciência Viva, Portugal

Sociedade Portuguesa de Células Estaminais e Terapia Celular, Portugal
2022/03/02 - 2022/03/02 Detection of Plagiarism with Urkund and MOSS
Workshop
2021/04/08 - 2021/04/08 Bioprocessing 2021 organized by LabRoots
Workshop
2021/02/18 - 2021/02/23 Teaching STEM Students - A workshop for TA's, 4th Edition (8 hours) - IST Academic Development Office
Workshop
 Teaching STEM Students
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/02/02 - 2020/02/02 Emotional intelligence to power the teaching learning process (7 hours) - IST Academic Development Office
Workshop
 Emotional intelligence to power the teaching learning process
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/11/12 - 2018/11/15 2nd FLxFlow Course: Principles and Applications of Flow Cytometry (40 hours) Instituto Gulbenkian Ciência.
Workshop
 2nd FLxFlow Course: Principles and Applications of Flow Cytometry
Instituto Gulbenkian de Ciência, Portugal
2016/10/17 - 2016/10/17 Cancer Cell Migration in Space and Time
Workshop
 Projec ReTuBi
Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal
2016/06/27 - 2016/06/27 II Workshop of Stem Cells: From Basic Research to Therapeutic Application
Workshop
Centro Hospitalar e Universitário de Coimbra EPE, Portugal
2016/05/25 - 2016/05/25 Clinical trials of the investigator's initiative, organized by PtCRIN
Workshop
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP, Portugal
2013/07/19 - 2013/07/19 International Conference on Stem Cells for Drug Screening and Regenerative Medicine
Biocant Associação de Transferência de Tecnologia, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2021/12 Cardiac differentiation of human induced Pluripotent Stem Cells in Vertical-Wheel bioreactors
(Thesis) Main arguer
 Inês Ribeiro (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2021/07 Tridimensional culture approaches to advance representation of the tumor microenvironment in preclinical and translational research
(Thesis) Main arguer
 Maria Teresa Franchi Mendes (PhD)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2021/01/19 Cultured meat from stem cells: challenges and prospects
(Thesis) Main arguer
 Gonçalo Filipe Marques Fernando (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2020/11/21 Mesenchymal Stromal Cell-based Strategies to Enhance Tissue Vascularization: Exploring Magnetic Field Stimulation and Design of Fluidic Models for Vascular Studies
(Thesis) Arguer
 Ana Carina Baeta Manjua (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/11 Development of a non-invasive method for the in vitro monitoring of 3D cell cultures
(Thesis) Main arguer
 Maria Margarida Rodrigues (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/11 Exploring a xenogeneic-free manufacturing process for the ex-vivo expansion of Human Periosteum-Derived Stem Cells
(Thesis) Main arguer
 Margarida Uva (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/12/11 Scalable platform for the expansion of human mesenchymal stem/stromal cells under dynamic conditions
(Thesis) Arguer
 Francisco António Guilherme Moreira (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/11 Optimization of a Xeno(geneic)-free microcarrier-based culture system for the expansion of human mesenchymal stem cells
(Thesis) Main arguer
 Filipa Inês de Carvalho Guimarães (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/11 Separation of CHO-derived vesicles through multimodal and heparin affinity chromatogray
(Thesis) Main arguer
 Ana Francisca Dias Gomes Candeias (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/11 Unveiling human Cardiac Stem Cells role in myocardial ischemia-reperfusion injury
(Thesis) Main arguer
 Ivo Miguel Ferreira da Paixão Reis (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2018/10 Comparação da análise morfológica de embriões humanos de processos de procriação medicamente assistida com o perfil molecular do meio de cultura
(Thesis) Main arguer
 Joana de Sousa Emídio dos Santos (Master)
Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2017/12/13 Effect of industrial GMP human plasma derived supplement on hMSC behaviour
(Thesis) Main arguer
 Maura Cimino (PhD)
Universidade do Porto Faculdade de Engenharia, Portugal
2017/12/04 Heparin Functionalization of Fibrin Hydrogels for Tissue Engineering
(Thesis) Main arguer
 Jéssica Reais Ramalho (Master)
Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2017/11/03 Scalable expansion and harvesting of hiPSCs using dissolvable microcarriers
(Thesis) Main arguer
 André Lopes Rodrigues (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2017/05 Engineering the microenvironment of Mesenchymal Stem/Stromal Cells to tune their trophic activity
(Thesis) Arguer
 Marta Helena Guerreiro Costa (PhD)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/03/01 Molecular Stimulation of MSCs for Improved Cell Retention and Functional Responses
(Thesis) Main arguer
 Ana Cláudia Correia Grácio (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/11/24 The effect of key process parameters on human mesenchymal stem cell expansion and harvest
(Thesis) Main arguer
 Gonçalo Nuno Barata Fonte (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/09 Developing an advanced therapy medicinal product (ATMP) for the treatment of GvHD
(Thesis) Main arguer
 Brígida Isabel do Amaral Neves Antunes (Master)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2014/07/22 Expansion of multipotent mesenchymal stromal cells on gelatin coated alginate microcarriers
(Thesis) Main arguer
 Samuel Duarte Jorge (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/11/21 Developing an Advanced Therapy Medicinal Product (ATMP) for regulatory approval: optimization of product release and shelf-life
(Thesis) Main arguer
 Bernardo Martins da Cunha Abecasis (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal
2013/06/26 Optimizing the production of human mesenchymal stem/stromal cells in xeno-free microcarrier-based reactor systems
(Thesis) Main arguer
 Joana Isabel Gonçalves Carmelo (Master)
Universidade de Lisboa Instituto Superior Técnico, Portugal

Committee member

Activity description
Role 		Institution / Organization
2019/02/22 - 2019/02/23 Abstract selection for the 6th IEEE Portuguese Meeting on Bioengineering (ENBENG 2019) organized by IEEE EMBS Portugal Chapter. Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal

Conference scientific committee

Conference name Conference host
2022/03/10 - 2022/03/11 12th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) Universidade do Minho - ICVS
2019/10/10 - 2019/10/12 11th International Meeting of the Portuguese Society for Stem Cells and Cell Therapies (SPCE-TC) iMed.ULisboa / Faculdade de Farmácia da Universidade de Lisboa, Portugal
2019/05/08 - 2019/05/11 33rd EUROPEAN IMMUNOGENETICS AND HISTOCOMPATIBILITY CONFERENCE CCB, Lisboa, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2017/01/01 - Current Participation in the module "From clinic to molecular biology II" Medicina (Mestrado integrado) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/01/01 - Current Participation in the module "Cell and Tissue Engineering" Engenharia Biomédica (Mestrado integrado) Instituto Politécnico de Lisboa Instituto Superior de Engenharia de Lisboa, Portugal
2015/09/01 - Current Cell and Tissue Engineering Engenharia Biomédica (Licenciatura) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - Current Project in Biotechnology Biotecnologia (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - Current Cell and Tissue Engineering Biotecnologia (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - Current Cell and Tissue Engineering Microbiologia (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2015/09/01 - Current Cell and Tissue Engineering Bioengenharia e Nanossistemas (Mestrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/09/01 - Current Cell and Tissue Engineering Engenharia Biológica (Mestrado integrado) Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/01/01 - 2018 Participation in the module "Biology and Technology of Stem Cells" Biologia Evolutiva e do Desenvolvimento (Mestrado) Universidade de Lisboa Faculdade de Ciências, Portugal
2014/01/01 - 2017/12/31 Cell and Tissue Engineering module of the MIT-Portugal PhD program in Bioengineering Systems (IST) (Doutoramento) Universidade de Lisboa Instituto Superior Técnico, Portugal
2014/10/21 - 2014/10/22 Advance Course: Cell Therapy- The Importance of Stem Cells, Progenitor Cells and Mature cells in Transfusion Medicine and Transplantation (Outros) Instituto Português do Sangue e da Transplantação IP, Portugal

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022/01 - Current Comissão de Acompanhamento de Tese de Doutoramento de Luis Pires Manuel Ramalhete
Member
 Universidade Nova de Lisboa Comprehensive Health Research Centre, Portugal
2019/07 - 2019/07 Comissão de Acompanhamento de Tese de Doutoramento de Sara Morini
Member
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2019/02 - 2019/02 Comissão de Acompanhamento de Tese de Doutoramento de Ana Carina Manjua
Evaluator
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2018/07 - 2018/07 Comissão de Acompanhamento de Tese de Doutoramento de Sara Alexandra Rosa
Evaluator
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/09 - 2016/09 Comissão de Acompanhamento de Tese de Doutoramento de Francisco Moreira
Evaluator
 Universidade de Lisboa Instituto Superior Técnico, Portugal
2016/01 - 2016/01 Comissão de Acompanhamento de Tese de Doutoramento de Marta Helena Guerreiro Costa
Evaluator
 Universidade de Lisboa Instituto Superior Técnico, Portugal