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Identification

Personal identification

Full name
Diana Pádua

Citation names

  • D. Pádua

Author identifiers

Ciência ID
EB17-E082-EFEA
ORCID iD
0000-0002-5780-9842

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Molecular Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Natural sciences - Biological Sciences - Biochemical Research Methods
  • Medical and Health Sciences - Basic Medicine - Toxicology
  • Medical and Health Sciences - Basic Medicine - Medicinal Chemistry
Outputs

Publications

Conference poster
  1. D. Pádua; P. Figueira; J. Peixoto; R.T. Lima; A. Pombinho; C.F. Pereira; R. Almeida; P. Mesquita. "Ciclopirox and HMGA1 may act together in promoting a gastric cancer stem-like phenotype". Paper presented in 30th Porto Cancer Meeting - RNA Biology in cancer: fundamentals and clinical relevance, 2024.
  2. P. Mesquita; A. Coelho; A.S. Ribeiro; L.F.C. Póvoas; N. Leça; C. de Oliveira; D. Ferreira; et al. "YTHDF3 contributes to an aggressive phenotype in gastric cancer". Paper presented in 30th Porto Cancer Meeting - RNA Biology in cancer: fundamentals and clinical relevance, 2024.
  3. I. Monteiro; D. F. Pinto; D. Pádua; C. F. Pereira; R. Almeida; P. Mesquita. "Evaluation of the role of HMGA1 protein in colon cancer stem cells". Paper presented in IJUP - Encontro de Investigação Jovem da U.Porto, 2024.
  4. D. Pádua; P. Figueira; M. Pinto; A. F. Maia; J. Peixoto; R. T. Lima; A. Pombinho; et al. "Ciclopirox no tratamento do cancro do estômago: eficácia anti-tumoral comprometida pela biogénese de células estaminais do cancro do estômago (Ciclopirox in the treatment of stomach cancer: antitumor efficacy compromised by stomach cancer stem cell biogenesis)". Paper presented in 5º Encontro Nacional de Jovens Investigadores em Oncologia, 2023.
  5. D. Pádua; P. Figueira; J. Peixoto; R. T. Lima; A. Pombinho; C. F. Pereira; R. Almeida; P. Mesquita. "Ciclopirox in Gastric Cancer Therapy: Promising Anticancer Efficacy Tempered by the Promotion of Cancer Stem-Like Cells Biogenesis". Paper presented in EACR Conference: Stem Cell Biology, Cancer Plasticity and Therapeutic Potential, 2023.
  6. D. Pádua; M. Pinto; P. Figueira; C. F. Pereira; R. Almeida; P. Mesquita. "A Hipóxia Química induz Células Estaminais do Cancro do Estômago (Chemical Hypoxia Induces Stomach Cancer Stem Cells)". Paper presented in 4º Encontro Nacional de Jovens Investigadores em Oncologia, 2022.
    https://doi.org/10.54499/SFRH/BD/146186/2019
  7. D. Pádua; M. Pinto; P. Figueira; C. F. Pereira; R. Almeida; P. Mesquita. "Chemical hypoxia originates gastric cancer stem-like cells via upregulation of SOX2 and c-MYC expression". Paper presented in 5th ASPIC International Congress, 2022.
  8. D. Pádua; P. Figueira; CF. Pereira; P. Mesquita; R. Almeida. "HMGA1 overexpression promotes gastric cancer stem-like cell phenotype via upregulation of SOX2 and c-Myc expression". Paper presented in 28th Porto Cancer Meeting - Extracellular Vesicles, Cell Communication and Cancer, 2022.
  9. D. Pádua; I. Ribeiro; P. Figueira; A. F. Freire; C. F. Pereira; R. Almeida; P. Mesquita. "HMGA1 overexpression increases the levels of key reprogramming transcription factors in a non-CSC colon population". Paper presented in 28th Porto Cancer Meeting - Extracellular Vesicles, Cell Communication and Cancer, 2022.
  10. D. Pádua; P. Figueira; C. F. Pereira; P. Mesquita; R. Almeida. "HMGA1 overexpression induces gastric cancer stem cell phenotype". Paper presented in 12th International Meeting of the Portuguese Society for Stem cells and Cell Therapies (SPCE-TC), 2022.
  11. D. Pádua; I. Ribeiro; P. Figueira; AF. Freire; R. Almeida; P. Mesquita. "HMGA1 rises the expression of key reprogramming transcription factors in a non-CSC colon population". Paper presented in 12th International Meeting of the Portuguese Society for Stem cells and Cell Therapies (SPCE-TC), 2022.
  12. D. Pádua; P. Figueira; P. Mesquita; C. F. Pereira; R. Almeida. "HMGA1: a potential valuable player on gastric cancer stem cells reprogramming". Paper presented in 27th Porto Cancer Meeting, 2021.
  13. CV de Oliveira; LFC Póvoas; D Ferreira; D. Pádua; P Mesquita; Pereira, B.; C Jerónimo; R Almeida. Corresponding author: CV de Oliveira. "Epitranscriptomics in gastric cancer: the role of of YTHDF3 in tumor characterization". Paper presented in 27th PORTO CANCER MEETING | Stemness & Metastasis: Advances in Research and Clinical Translation, 2021.
  14. P. Figueira; D. Pádua; P. Mesquita; R. Almeida. "Expressão aberrante de MUC2 em carcinoma gástrico (Aberrant expression of MUC2 in gastric carcinoma)". Paper presented in 2º Encontro Nacional de Jovens Investigadores em Oncologia, 2020.
  15. I. Ribeiro; D. Pádua; A. F. Freire; P. Figueira; R. Almeida; P. Mesquita. "Identification of transcription factors associated with a cancer stem cell phenotype in colon cancer cells". Paper presented in XII Jornadas de Genética e Biotecnologia / II Jornadas Ibéricas de Genética y Biotecnologia, 2020.
  16. Henriques, Taciane; Santos, Diandra dos; Guimaraes, Isabella; Tessarollo, Nayara; Lyra, Paulo; Mesquisa, Patricia; Pádua, Diana; et al. "Abstract A133: Role of CXCR2 in the acquisition of pan-resistant phenotype in high grade serous ovarian cancer cells". Paper presented in AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Hynes Convention Center, Boston, Massachusetts, Estados Unidos da América, 2019.
    10.1158/1535-7163.targ-19-a133
  17. D. Pádua; R. Barros; A. Amaral; P. Mesquita; H. Fernandes; AR. Pombinho; CF. Pereira; R. Almeida. "SOX2 é um marcador funcional de células estaminais do cancro gástrico (SOX2 is a functional marker of gastric cancer stem cells)". Paper presented in 1º Encontro Nacional de Jovens Investigadores em Oncologia, Liga Portuguesa Contra o Cancro – Núcleo Regional do Norte, Porto, Portugal, 2019.
  18. A. F. Freire; D. Pádua; S. Ribeirinho-Soares; F. Pereira; P. Mesquita; R. Almeida. "Isolation and characterization of intestinal CSCs using a traceable lentiviral-based reporter system". Paper presented in 7th i3S annual meeting, Axis Vermar Conference & Beach Hotel, Póvoa do Varzim, Portugal, 2018.
  19. S. Ribeirinho; P. Mesquita; A. F. Freire; D. Pádua; R. Coelho; C. Marques; R. Barros; et al. "SOX2 as a predictive biomarker of resistance to therapy in stage II CRC patients". Paper presented in 7th i3S annual meeting, Axis Vermar Conference & Beach Hotel, Póvoa do Varzim, Portugal, 2018.
  20. Pádua, Diana; Barros, Rita; Almeida, Raquel. "Isolation and characterization of gastric cancer stem cells based on SOX2/OCT4 activity". Paper presented in IJUP 10ª edição – Encontro de Investigação Jovem Universidade do Porto, Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal, 2017.
Journal article
  1. D. Pádua; Figueira, Paula; Pombinho, António; Monteiro, Inês; Pereira, Carlos Filipe; Almeida, Raquel; Mesquita, Patrícia. "HMGA1 stimulates cancer stem-like features and sensitivity to monensin in gastric cancer". Experimental Cell Research 442 2 (2024): 114257. http://dx.doi.org/10.1016/j.yexcr.2024.114257.
    10.1016/j.yexcr.2024.114257
  2. T. Vilarinho; D. Pádua; B. Pereira; P. Mesquita; R. Almeida. "MISP Is Overexpressed in Intestinal Metaplasia and Gastric Cancer". Current Oncology 31 5 (2024): https://doi.org/10.3390/curroncol31050210.
    Published • 10.3390/curroncol31050210
  3. Pádua, Diana; Figueira, Paula; Pinto, Mariana; Maia, André Filipe; Peixoto, Joana; Lima, Raquel T.; Pombinho, António; et al. "High-Throughput Drug Screening Revealed That Ciclopirox Olamine Can Engender Gastric Cancer Stem-like Cells". Cancers 15 17 (2023): 4406. http://dx.doi.org/10.3390/cancers15174406.
    10.3390/cancers15174406
  4. Pádua, Diana; Pinto, Débora Filipa; Figueira, Paula; Pereira, Carlos Filipe; Almeida, Raquel; Mesquita, Patrícia. "HMGA1 Has Predictive Value in Response to Chemotherapy in Gastric Cancer". Current Oncology 29 1 (2021): 56-67. http://dx.doi.org/10.3390/curroncol29010005.
    10.3390/curroncol29010005
  5. Henriques, Taciane Barbosa; dos Santos, Diandra Zipinotti; dos Santos Guimarães, Isabella; Tessarollo, Nayara Gusmão; Lyra-Junior, Paulo Cilas Morais; Mesquita, Patricia; Pádua, Diana; et al. "Inhibition of CXCR2 plays a pivotal role in re-sensitizing ovarian cancer to cisplatin treatment". Aging 13 10 (2021): 13405-13420. http://dx.doi.org/10.18632/aging.203074.
    Published • 10.18632/aging.203074
  6. Ribeirinho-Soares, Sara; Pádua, Diana; Amaral, Ana Luísa; Valentini, Elvia; Azevedo, Daniela; Marques, Cristiana; Barros, Rita; et al. "Prognostic significance of MUC2, CDX2 and SOX2 in stage II colorectal cancer patients". BMC Cancer 21 1 (2021): http://dx.doi.org/10.1186/s12885-021-08070-6.
    Published • 10.1186/s12885-021-08070-6
  7. Pádua, Diana; Figueira, Paula; Ribeiro, Inês; Almeida, Raquel; Mesquita, Patrícia. "The Relevance of Transcription Factors in Gastric and Colorectal Cancer Stem Cells Identification and Eradication". Frontiers in Cell and Developmental Biology 8 (2020): http://dx.doi.org/10.3389/fcell.2020.00442.
    Published • 10.3389/fcell.2020.00442
  8. Pádua, Diana; Barros, Rita; Amaral, Ana Luísa; Mesquita, Patrícia; Freire, Ana Filipa; Sousa, Mafalda; Maia, André Filipe; et al. "A SOX2 Reporter System Identifies Gastric Cancer Stem-Like Cells Sensitive to Monensin". Cancers 12 2 (2020): 495. http://dx.doi.org/10.3390/cancers12020495.
    Published • 10.3390/cancers12020495
  9. Pádua, Diana; Rocha, E.; Gargiulo, D.; Ramos, A.A.. "Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer". Phytochemistry Letters 14 (2015): 91-98. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942853309&partnerID=MN8TOARS.
    10.1016/j.phytol.2015.09.007

Intellectual property

Provisional application for patent
  1. 2019. "USE OF MONENSIN IN A METHOD FOR THE TREATMENT OF CANCER WITH FOCUS ON CANCER STEM CELLS".
    Protected
  2. 2019. "USE OF CPX FOR INDUCTION OF STEM CELL€S PROPERTIES".
    Protected
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2019/10/11 SOX2 is a functional marker of gastric cancer stem cells 11th Edition of the International Meeting of the Portuguese Society for Stem Cells & Cell Therapies
(Lisboa, Portugal)
2019/05/02 SOX2 is a functional marker of gastric cancer stem cells 26th Porto Cancer Meeting & 5th Joint Meeting Porto-Bordeaux 2019
Instituto de Investigação e Inovação da Universidade do Porto (Porto, Portugal)
2019/01/16 CSC reprogramming: reconstructing the transcription factor CANCEL STEM Consortium Meeting
UC-BIOTECH, Biocant Park, CNC (Cantanhede, Portugal)
2017/11/10 Isolation and characterization of gastric cancer stem cells based on SOX2/OCT4 activity 6th i3S annual meeting
(Póvoa do Varzim, Portugal)

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2022/10/04 - 2022/10/06 Introduction to Full Spectrum Profiling™ using the Cytek® System + SpectroFlo® Demo - Aurora/Northern Lights (Cytek Flow Cytometry) Training
Other
 Introduction to Full Spectrum Profiling™ using the Cytek® System + SpectroFlo® Demo - Aurora/Northern Lights (Cytek Flow Cytometry) Training
Cytek Biosciences Inc, United States

Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2021/09/24 - 2021/09/24 Webinars/Web Conferences: 3º Encontro Nacional de Jovens Investigadores em Oncologia (3rd National Meeting of Young Researchers in Oncology)
Meeting
 3º Encontro Nacional de Jovens Investigadores em Oncologia
Liga Portuguesa Contra o Cancro Núcleo Regional do Norte, Portugal
2020/09/25 - 2020/09/25 Webinars/Web Conferences: Cancer Biology: From Basic to Translational Research Cancer Biology: From Basic to Translational Research
Liga Portuguesa Contra o Cancro, Portugal
2020/09/14 - 2020/09/18 PhD Advanced Course on Molecular Biomarkers and Technologies
Other
 PhD Advanced Course on Molecular Biomarkers and Technologies
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/06/30 - 2020/06/30 Webinars/Web Conferences: Impacts of Covid-19 on cancer diagnosis and treatment Impacts of Covid-19 on cancer diagnosis and treatment
Imperial College Academic Health Science Centre (AHSC) - Imperial College London, United Kingdom
2018/04/24 - 2018/04/24 High-Dimensional Single Cell Analysis
Workshop
 High-Dimensional Single Cell Analysis, Izasa Scientific
2015/10/25 - 2015/10/25 O mar como fonte de potenciais agentes anticancerígenos (The sea as a source of potential anticancer agents) - Authors: Alice Ramos, B. Castro-Carvalho, M. Prata-Sena, D. Gargiulo, F. Malhão, M. Moreira, P. Marques, E. Costa, D. Pádua, N. Oliveira, Tida Dethoup, Suradet Buttachon, Anake Kijjoa, Eduardo Rocha.
Congress
 III CONGRESSO NATURALES MEDICINAE – Doenças Oncológicas
2015/05/25 - 2015/05/25 Marine-derived fungi extracts and isolated compounds as anti-proliferative and cell death-inducing agents in human cancer cell lines. Authors: Alice Ramos, B. Castro-Carvalho, M. Prata-Sena, D. Gargiulo, F. Malhão, M. Moreira, P. Marques, E. Costa, D. Pádua, N. Oliveira, Tida Dethoup, Suradet Buttachon, Anake Kijjoa, Eduardo Rocha
Meeting
 MARBIOTECH - Survey of natural substances from marine organisms with potential pharmacological and ecological applications
Universidade do Porto Centro Interdisciplinar de Investigação Marinha e Ambiental, Portugal
2014/11/17 - 2014/11/17 From gene to genius 1st annual symposium of the Doctoral Program in Molecular and Cell Biology
Symposium
 From gene to genius. 1st annual symposium of the Doctoral Program in Molecular and Cell Biology
Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2014/05/14 - 2014/05/14 Ciências Forenses (Forensic Sciences)
Workshop
 Ciências Forenses
Universidade do Porto Faculdade de Ciências, Portugal
2013/12/19 - 2013/12/19 SPI Workshop – Thymus @ Porto II
Workshop
 SPI Workshop – Thymus @ Porto II
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Universidade do Porto Instituto de Biologia Molecular e Celular, Portugal
2013/11/27 - 2013/11/27 Bioinvasões num contexto de Alterações Climáticas: Implicações para a Saúde Ambiental, Animal e Humana (Bioinvasions in a context of Climate Change: Implications for Environmental, Animal and Human Health)
Workshop
 Bioinvasões num contexto de Alterações Climáticas: Implicações para a Saúde Ambiental, Animal e Humana
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2018/07/11 Avaliação do Efeito Antitumoral de Compostos Naturais de Origem Marinha (Evaluation of the Antitumor Effect of Natural Compounds of Marine Origin)
(Thesis) Main arguer
 Sofia de Almeida Mateus (Other)
Universidade do Porto Faculdade de Ciências, Portugal

Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
Distinctions

Award

2024 Cancers 2024 Best PhD Thesis Award
Cancers, Switzerland

Other distinction

2019 FCT PhD Studentships
Fundação para a Ciência e a Tecnologia, Portugal