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Paul M. D'Agostino is a molecular microbiologist with of focus on natural product biosynthesis, genome mining and biochemistry. He completed his PhD 2014 at the Western Sydney University followed by a Postdoctoral position at the University of New South Wales (Australia) and the Technische Universität München via a competitive Technische Universität München Foundation Fellowship and a prestigious Marie Sklodowska-Curie Actions Individual Fellowship. Paul M. D'Agostino has an excellent track record for the stage of his career including 39 publications (18 first authorship, 2203 citations, H-index = 21, i10-index = 19), and a single author review (Natural Product Reports) describing his current state of his research niche. He also has 2 publications almost ready for submission including a first author and a corresponding author position. Paul M. D'Agostino has also presented at many national and international conferences including 15 oral presentations (4 invited, 2 keynote) and 23 posters. He has attended a variety of workshops and has managed to obtain competitive funding including several awards and research grants. Paul M. D'Agostino has also been involved in student supervision of PhD, Masters and Bachelor level including research internships, practical courses and lectures. Paul M. D'Agostino is currently located at the Technische Universität Dresden and the Helmholtz Institute of Pharmaceutical Research Saarland (HIPS) with a focus on natural product discovery via genome mining, direct pathway cloning and heterologous expression.
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Identification

Personal identification

Full name
Paul DAgostino

Author identifiers

Ciência ID
EC1D-9418-19A8
ORCID iD
0000-0002-8323-5416

Addresses

  • Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) Campus E8.1 , 66123 , Saarbrücken, Saarland, Germany (Professional)

Websites

Affiliation

Science

Category
Host institution 		Employer
2023/09/01 - Current Researcher (Research) Helmholtz Institute of Pharmaceutical Research Saarland, Germany
Helmholtz-Zentrum für Infektionsforschung GmbH, Germany
Projects

Other

Designation Funders
2021 - Current Symbiotic cyanobacteria: An untapped source of novel biosynthetic logic and chemical diversity
Technical University of Dresden Research Pool Fund
Principal investigator
Technische Universität Dresden, Germany
2021 - Current Symbiotic cyanobacteria: An untapped source of novel biosynthetic logic and chemical diversity
Hans Fischer Society
Principal investigator
2021 - Current Novel ultraviolet radiation filters from cyanobacteria
PPP Programme for Project-Related Personal Exchange with Australia
Principal investigator
2020 - Current Exploration of cyanobacterial pharmaceutic lasso-peptides by DiPaC (Direct Pathway Cloning)
57560020
Principal investigator
2019 - Current Novel ultraviolet radiation filters from extreme environments
DP190103314
Principal investigator
Australian Research Council
2018 - Current Biosynthese des cyanobakteriellen Sekundärstoffs Cyanobakterin, ein potenter Inhibitor von Photosystemen
Hans Fischer Society
Principal investigator
Outputs

Publications

Book chapter
  1. D’Agostino, Paul M.; Moffitt, Michelle; Neilan, Brett. "Current Knowledge of Paralytic Shellfish Toxin Biosynthesis, Molecular Detection and Evolution". In Toxins and Biologically Active Compounds from Microalgae, Volume 1, edited by Rossini, GP, 251-280. CRC Press, 2014.
    Published • 10.1201/b16569-13
  2. Hennell, J.R.; D'Agostino, P.M.; Lee, S.; Khoo, C.S.; Sucher, N.J.. "Using genbank® for genomic authentication: A tutorial". In Plant DNA Fingerprinting and Barcoding, edited by Nikolaus J. Sucher; James R. Hennell; Maria C. Carles. Humana Press, 2012.
    Published • 10.1007/978-1-61779-609-8_15
Conference poster
  1. DAgostino, Paul. "Potential elicitation of staurosporine production". Paper presented in World Microbe Forum, 2021.
  2. Lamm, K; Greunke, C; Duell, ER; D'Agostino, PM; Glöckle, A; Gulder, TAM. "Unlocking the metabolic potential of selected biosynthetic gene clusters using DiPaC". Paper presented in John Innes/Rudjer Boškovic Summer School on “Microbial Specialised Metabolites: From Genome to Molecule, 2018.
  3. Cullen, Alescia; D’Agostino, PM; Mazmouz, R; Neilan, BA. "Understanding differential toxin profiles between two Scytonema cf. crispum strains". Paper presented in John Innes/Rudjer Boškovic Summer School on “Microbial Specialised Metabolites: From Genome to Molecule", 2018.
  4. Duell, ER; D'Agostino, PM; Greunke, C; Lamm, K; Glöckle, A; Gulder, TAM. "Unlocking the biosynthetic potential of cyanobacterial secondary metabolites using direct pathway cloning and heterologous expression". Paper presented in Gordon Research Seminars on Natural Products and Bioactive Compounds (GRS). Frontiers in Natural Products: Synthesis, Biosynthesis, and Drug Discovery, 2018.
  5. Pereyra, JPA; D’Agostino, PM.; Greunke, C; Lamm, K; Glöckle, A; Gulder, TAM. "Genomic analysis of PST-producing strains for determining toxin profile formation". Paper presented in Gordon Research Seminars on Natural Products and Bioactive Compounds (GRS). Frontiers in Natural Products: Synthesis, Biosynthesis, and Drug Discovery, 2018.
  6. D’Agostino, PM.; Rappolder, SE; Gulder, TAM. "Genome mining and Direct Pathway Cloning (DiPaC) for natural product discovery in Gordonia polyisoprenivorans WS4843". Paper presented in Applied Natural Products: from discoveries to innovations, 2018.
  7. Duell, ER; D'Agostino, PM; Greunke, C; Lamm, K.; Glöckle, A; Gulder, TAM. "Direct pathway cloning and heterologous expression of cyanobacterial secondary metabolites". Paper presented in Applied Natural Products: from discoveries to innovations, 2018.
  8. Pereyra, JPA; D’Agostino, PM; Woodhouse, JN; Neilan, BA. "Molecular and physiological survey of saxitoxin-producing Anabaena circinalis isolated from geographically distinct regions of Australia". Paper presented in 10th International Conference on Toxic Cyanobacteria, 2016.
  9. Mazmouz, R; D'Agostino, PM; Chau, R; Katoch, M; Javalkote, V; Pickford, R; Pearson, L; Neilan, BA; Katoch, M.. "Cyanobacterial mycosporine-like amino acids: genetics, biosynthesis and heterologous expression". Paper presented in 13th International Symposium on the Genetics of Industrial Microorganisms, 2016.
  10. D’Agostino, PM.; Gulder, TAM. "Heterologous expression of the Serratia fonticola DSM4576 phenazine gene cluster". Paper presented in John Innes/Rudjer Boškovic Summer School on “Microbial Diversity and Specialised Metabolites", 2016.
  11. Pereyra, JPA; D’Agostino, PM; Woodhouse, JN; Neilan, BA. "Analysis of PST production amongst Anabaena circinalis strains". Paper presented in UNSW School of Biotechnology and Biomolecular Sciences Symposium, 2015.
  12. Micallef, ML; D'Agostino, PM; Sharma, D; Viswanathan, R; Moffitt, MC. "Complex secondary metabolite potential of the group V cyanobacteria revealed through whole genome sequencing". Paper presented in Natural Product Discovery and Development in the Post Genomic Era, 2015.
  13. D'Agostino, PM; Woodhouse, JN; Mazmous, R; Wood, S; Neilan, BA. "Insertions within the saxitoxin biosynthetic gene cluster gives rise to differential toxin profiles in the benthic cyanobacterium Scytonema crispum". Paper presented in 16th International Conference on Harmful Algae, 2014.
  14. D’Agostino, PM; Song, X; Neilan, BA; Moffitt, MC. "Proteomic analysis of a saxitoxin-producing and non-toxic strain of Anabaena circinalis reveal each is a distinct ecotype". Paper presented in 2nd PROTEOMICS & BEYOND Symposium, 2014.
  15. Yeung, A; D’Agostino, PM; Poljak, A; Pearson, L; Waite, TD; Neilan, BA. "Using iTRAQ to uncover growth rate dependent proteomic changes in Microcystis aeruginosa under iron limitation". Paper presented in 2nd PROTEOMICS & BEYOND Symposium, 2014.
  16. Micallef, ML; Sharma, D; D’Agostino, PM; Viswanathan, R; Moffitt, MC. "Biochemical characterisation of a prenyltransferase involved in the biosynthesis of the hapalindoles and welwitindolinones". Paper presented in Joint Academic Microbiology Seminars, 2013.
  17. D’Agostino, PM; Cavaliere, R; Jones, AC; Muenchhoff, J; Neilan, BA.; Moffitt, MC. "Transcriptional analysis of the saxitoxin biosynthetic gene cluster in cyanobacteria". Paper presented in Joint Academic Microbiology Seminars, 2012.
  18. D’Agostino, PM; Cavaliere, R; Jones, AC; Muenchhoff, J; Neilan, BA; Moffitt, MC. "Transcriptional analysis of the saxitoxin biosynthetic gene cluster in cyanobacteria". Paper presented in American Society of Pharmacognosy, 2011.
  19. Micallef, ML; D’Agostino, PM; Moffitt, MC. "Complex biosynthetic pathways revealed through genome sequencing of the cyanobacterium Westiella intricata HT-29-1". Paper presented in American Society of Pharmacognosy, 2011.
  20. Abas, M; D’Agostino, PM; Griffin, S; Moffitt, MC. "Investigation of geosmin biosynthesis gene transcription in cyanobacteria". Paper presented in American Society of Microbiology General conference, 2010.
  21. D’Agostino, PM; Abas, M; Kalaitzis, JK; Moffitt, MC. "Characterisation of the gene cluster responsible for the anti-cancer compound Hapalosin". Paper presented in Australian Society of Microbiology Conference, 2008.
Journal article
  1. Zdouc, Mitja M; Blin, Kai; Louwen, Nico L L; Navarro, Jorge; Loureiro, Catarina; Bader, Chantal D; Bailey, Constance B; et al. "MIBiG 4.0: advancing biosynthetic gene cluster curation through global collaboration". Nucleic Acids Research 53 D1 (2025): D678-D690. https://doi.org/10.1093/nar/gkae1115.
    Open access • Published • 10.1093/nar/gkae1115
  2. Mo, Xu-Hua; Pu, Qing-Yin; Lübken, Tilo; Yu, Gui-Hong; Malay, Mert; D’Agostino, Paul M.; Gulder, Tobias A.M.. "Discovery and biosynthesis of non-canonical C16-terpenoids from Pseudomonas". Cell Chemical Biology 31 12 (2024): 2128-2137.e4. https://doi.org/10.1016/j.chembiol.2024.09.002.
    Open access • Published • 10.1016/j.chembiol.2024.09.002
  3. Ilic-Tomic, Tatjana; Kramar, Ana; Kostic, Mirjana; Vojnovic, Sandra; Milovanovic, Jelena; Petkovic, Milos; D’Agostino, Paul M.; Gulder, Tobias A. M.; Nikodinovic-Runic, Jasmina. "Functionalization of silk with actinomycins from Streptomyces anulatus BV365 for biomedical applications". Frontiers in Bioengineering and Biotechnology 12 (2024): https://doi.org/10.3389/fbioe.2024.1466757.
    Open access • Published • 10.3389/fbioe.2024.1466757
  4. Bustos-Diaz, Edder D.; Cruz-Perez, Arely; Garfias-Gallegos, Diego; D'Agostino, Paul M.; Gehringer, Michelle M.; Cibrian-Jaramillo, Angelica; Barona-Gomez, Francisco. "Phylometagenomics of cycad coralloid roots reveals shared symbiotic signals". Microbial Genomics 10 3 (2024): http://dx.doi.org/10.1099/mgen.0.001207.
    Open access • Published • 10.1099/mgen.0.001207
  5. Ouyang, Xiaodan; D'Agostino, Paul M.; Wahlsten, Matti; Delbaje, Endrews; Jokela, Jouni; Permi, Perttu; Gaiani, Greta; et al. "Direct pathway cloning and expression of the radiosumin biosynthetic gene cluster". Organic & Biomolecular Chemistry 21 23 (2023): 4893-4908. http://dx.doi.org/10.1039/d3ob00385j.
    Open access • Published • 10.1039/d3ob00385j
  6. D'Agostino, Paul M.. Corresponding author: D'Agostino, Paul M.. "Highlights of biosynthetic enzymes and natural products from symbiotic cyanobacteria". Natural Product Reports 40 11 (2023): 1701-1717. http://dx.doi.org/10.1039/d3np00011g.
    Published • 10.1039/d3np00011g
  7. Stevanovic, Milena; D'Agostino, Paul M.; Mojicevic, Marija; Gulder, Tobias A. M.; Nikodinovic-Runic, Jasmina; Vojnovic, Sandra. "Streptomyces sp. BV410: Interspecies cross-talk for staurosporine production". Journal of Applied Microbiology 133 4 (2022): 2560-2568. http://dx.doi.org/10.1111/jam.15726.
    10.1111/jam.15726
  8. Eusébio, Nádia; Castelo-Branco, Raquel; Sousa, Diana; Preto, Marco; D’Agostino, Paul; Gulder, Tobias A. M.; Leão, Pedro N.. "Discovery and Heterologous Expression of Microginins from Microcystis aeruginosa LEGE 91341". ACS Synthetic Biology 11 10 (2022): 3493-3503. http://dx.doi.org/10.1021/acssynbio.2c00389.
    Published • 10.1021/acssynbio.2c00389
  9. D'Agostino, Paul M.; Seel, Catharina J.; Ji, Xiaoqi; Gulder, Tanja; Gulder, Tobias A. M.. "Biosynthesis of cyanobacterin, a paradigm for furanolide core structure assembly". Nature Chemical Biology 18 6 (2022): 652-658. http://dx.doi.org/10.1038/s41589-022-01013-7.
    Published • 10.1038/s41589-022-01013-7
  10. Jung, Patrick; D’Agostino, Paul M.; Brust, Katharina; Büdel, Burkhard; Lakatos, Michael. "Final Destination? Pinpointing Hyella disjuncta sp. nov. PCC 6712 (Cyanobacteria) Based on Taxonomic Aspects, Multicellularity, Nitrogen Fixation and Biosynthetic Gene Clusters". Life 11 9 (2021): 916. http://dx.doi.org/10.3390/life11090916.
    10.3390/life11090916
  11. Pearson, Leanne A.; D'Agostino, Paul M.; Neilan, Brett A.. "Recent developments in quantitative PCR for monitoring harmful marine microalgae". Harmful Algae 108 (2021): 102096. http://dx.doi.org/10.1016/j.hal.2021.102096.
    10.1016/j.hal.2021.102096
  12. Jung, Patrick; D’Agostino, Paul M.; Büdel, Burkhard; Lakatos, Michael. "Symphyonema bifilamentata sp. nov., the Right Fischerella ambigua 108b: Half a Decade of Research on Taxonomy and Bioactive Compounds in New Light". Microorganisms 9 4 (2021): 745. http://dx.doi.org/10.3390/microorganisms9040745.
    10.3390/microorganisms9040745
  13. Wylensek, David; Hitch, Thomas C. A.; Riedel, Thomas; Afrizal, Afrizal; Kumar, Neeraj; Wortmann, Esther; Liu, Tianzhe; et al. "A collection of bacterial isolates from the pig intestine reveals functional and taxonomic diversity". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-19929-w.
    Open access • 10.1038/s41467-020-19929-w
  14. D'Agostino, Paul M.; Yeung, Anna C. Y.; Poljak, Anne; David Waite, Trevor; Neilan, Brett A.. "Comparative proteomics of the toxigenic diazotroph Raphidiopsis raciborskii (cyanobacteria) in response to iron". Environmental Microbiology 23 1 (2020): 405-414. http://dx.doi.org/10.1111/1462-2920.15328.
    Published • 10.1111/1462-2920.15328
  15. Benaud, Nicole; Edwards, Richard J.; Amos, Timothy G.; D'Agostino, Paul M.; Gutiérrez-Chávez, Carolina; Montgomery, Kate; Nicetic, Iskra; Ferrari, Belinda C.. "Antarctic desert soil bacteria exhibit high novel natural product potential, evaluated through long-read genome sequencing and comparative genomics". Environmental Microbiology 23 7 (2020): 3646-3664. http://dx.doi.org/10.1111/1462-2920.15300.
    Published • 10.1111/1462-2920.15300
  16. Paul M. D'Agostino; Bakir Al-Sinawi; Rabia Mazmouz; Julia Muenchhoff; Brett A. Neilan; Michelle C. Moffitt. "Identification of promoter elements in the Dolichospermum circinale AWQC131C saxitoxin gene cluster and the experimental analysis of their use for heterologous expression". BMC Microbiology 20 (2020): 35. https://bmcmicrobiol.biomedcentral.com/articles/10.1186/s12866-020-1720-3.
    Open access • Published • 10.1186/s12866-020-1720-3
  17. Marija Mojicevic; Paul M. D'Agostino; Aleksandar Pavic; Sandra Vojnovic; Ramsankar Senthamaraikannan; Branka Vasiljevic; Tobias A. M. Gulder; Jasmina Nikodinovic-Runic. "Streptomyces sp. BV410 isolate from chamomile rhizosphere soil efficiently produces staurosporine with antifungal and antiangiogenic properties". MicrobiologyOpen 9 (2020): e986. https://onlinelibrary.wiley.com/doi/full/10.1002/mbo3.986.
    Open access • Published • 10.1002/mbo3.986
  18. Zhengyi Qian; Torsten Bruhn; Paul M. D'Agostino; Alexander Herrmann; Martin Haslbeck; Noémi Antal; Hans-Peter Fiedler; Ruth Brack-Werner; Tobias A. M. Gulder. "Discovery of the Streptoketides by direct cloning and rapid heterologous expression of a cryptic PKS II gene cluster from Streptomyces sp. Tü6314". The Journal of Organic Chemistry 85 2 (2019): 664-673. https://pubs.acs.org/doi/abs/10.1021/acs.joc.9b02741.
    Published • 10.1021/acs.joc.9b02741
  19. Tobias M. Milzarek; Manuel Einsiedler; Hülya Aldemir; Paul M. D’Agostino; Julia K. Evers; Gesa Hertrampf; Katharina Lamm; et al. "Bypassing Biocatalytic Substrate Limitations in Oxidative Dearomatization Reactions by Transient Substrate Mimicking". Organic Letters 21 12 (2019): 4520-4524. https://pubs.acs.org/doi/10.1021/acs.orglett.9b01398.
    Published • 10.1021/acs.orglett.9b01398
  20. Elke R. Duell; Paul M. D’Agostino; Nicole Shapiro; Tanja Woyke; Thilo M. Fuchs; Tobias A.M. Gulder. "Direct pathway cloning of the sodorifen biosynthetic gene cluster and recombinant generation of its product in E. coli". Microbial Cell Factories 18 (2019): 32. https://microbialcellfactories.biomedcentral.com/articles/10.1186/s12934-019-1080-6.
    Open access • Published • 10.1186/s12934-019-1080-6
  21. Paul M. D'Agostino; Michael J. Boundy; Tim D. Harwood; Wayne W. Carmichael; Brett A. Neilan; Susanna A. Wood. Corresponding author: Paul M. D'Agostino. "Re-evaluation of paralytic shellfish toxin profiles in cyanobacteria using hydrophilic interaction liquid chromatography-tandem mass spectrometry". Toxicon 158 (2019): 1-7. https://doi.org/10.1016/j.toxicon.2018.11.301.
    Published • 10.1016/j.toxicon.2018.11.301
  22. Marija Mojicevic; Paul M. D’Agostino; Jasmina Nikodinovic-Runic; Branka Vasiljevic; Tobias A.M. Gulder; Sandra Vojnovic. "Antifungal potential of bacterial rhizosphere isolates associated with three ethno-medicinal plants (poppy, chamomile, and nettle)". International Microbiology 22 (2019): 343-353. https://link.springer.com/article/10.1007%2Fs10123-019-00054-8.
    Published • 10.1007/s10123-019-00054-8
  23. Paul M. D'Agostino; Jason N. Woodhouse; Heng Tai Liew; Ludek Sehnal; Russel Pickford; Hon Lun Wong; Brendan P. Burns; Brett A. Neilan. "Bioinformatic, phylogenetic and chemical analysis of the UV-absorbing compounds scytonemin and mycosporine-like amino acids from the microbial mat communities of Shark Bay, Australia". Environmental Microbiology 21 2 (2018): 702-715. https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/1462-2920.14517.
    Published • 10.1111/1462-2920.14517
  24. Cullen, Alescia; D’Agostino, Paul M.; Mazmouz, Rabia; Pickford, Russell; Wood, Susanna; Neilan, Brett A.. "Insertions within the Saxitoxin Biosynthetic Gene Cluster Result in Differential Toxin Profiles". ACS Chemical Biology 13 11 (2018): 3107-3114. https://pubs.acs.org/doi/10.1021/acschembio.8b00608.
    Published • 10.1021/acschembio.8b00608
  25. Paul M. D’Agostino; Tobias A. M. Gulder. "Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression". ACS Synthetic Biology 7 7 (2018): 1702-1708. https://pubs.acs.org/doi/10.1021/acssynbio.8b00151.
    Open access • Published • 10.1021/acssynbio.8b00151
  26. Christian Greunke; Elke Regina Duell; Paul Michael D’Agostino; Anna Glöckle; Katharina Lamm; Tobias Alexander Marius Gulder. "Direct Pathway Cloning (DiPaC) to unlock natural product biosynthetic potential". Metabolic Engineering 47 (2018): 334-345. https://www.sciencedirect.com/science/article/abs/pii/S1096717618300247?via%3Dihub.
    Published • 10.1016/j.ymben.2018.03.010
  27. Joao P.A. Pereyra; Paul M. D'Agostino; Rabia Mazmouz; Jason N. Woodhouse; Russell Pickford; Ian Jameson; Brett A. Neilan. "Molecular and morphological survey of saxitoxin-producing cyanobacterium Dolichospermum circinale ( Anabaena circinalis ) isolated from geographically distinct regions of Australia". Toxicon 138 (2017): 68-77. https://www.sciencedirect.com/science/article/pii/S0041010117302428?via%3Dihub.
    Published • 10.1016/j.toxicon.2017.08.006
  28. Anna C. Y. Yeung; Paul M. D'Agostino; Anne Poljak; James McDonald; Mark W. Bligh; T. David Waite; Brett A. Neilan; R. M. Kelly. "Physiological and Proteomic Responses of Continuous Cultures of Microcystis aeruginosa PCC 7806 to Changes in Iron Bioavailability and Growth Rate". Applied and Environmental Microbiology 82 19 (2016): 5918-5929. https://doi.org/10.1128/AEM.01207-16.
    Published • 10.1128/AEM.01207-16
  29. Paul M. D'Agostino; Vivek S. Javalkote; Rabia Mazmouz; Russell Pickford; Pravin R. Puranik; Brett A. Neilan; H. Nojiri. "Comparative Profiling and Discovery of Novel Glycosylated Mycosporine-Like Amino Acids in Two Strains of the Cyanobacterium Scytonema cf. crispum". Applied and Environmental Microbiology 82 19 (2016): 5951-5959. https://aem.asm.org/content/82/19/5951.
    Open access • Published • 10.1128/AEM.01633-16
  30. Pearson, L; Dittmann, E; Mazmous, R; Ongley, S; D’Agostino, PM; Neilan, BA. "The genetics, biosynthesis and regulation of toxic specialized metabolites of cyanobacteria". Harmful Algae 54 (2016): 98-111. https://www.sciencedirect.com/science/article/pii/S1568988315301517.
    Published • 10.1016/j.hal.2015.11.002
  31. Paul M. D'Agostino; Jason N. Woodhouse; A. Katharina Makower; Anna C. Y. Yeung; Sarah E. Ongley; Melinda L. Micallef; Michelle C. Moffitt; Brett A. Neilan. "Advances in genomics, transcriptomics and proteomics of toxin-producing cyanobacteria". Environmental Microbiology Reports 8 1 (2015): 3-13. https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/1758-2229.12366.
    Published • 10.1111/1758-2229.12366
  32. Paul M. D'Agostino; Xiaomin Song; Brett A. Neilan; Michelle C. Moffitt. "Proteogenomics of a saxitoxin-producing and non-toxic strain of A nabaena circinalis (cyanobacteria) in response to extracellular NaCl and phosphate depletion". Environmental Microbiology 18 2 (2015): 461-476. https://sfamjournals.onlinelibrary.wiley.com/doi/abs/10.1111/1462-2920.13131.
    Published • 10.1111/1462-2920.13131
  33. Micallef, ML; D'Agostino, PM; Sharma, D; Viswanathan, R; Moffitt, MC. "Genome mining for natural product biosynthetic gene clusters in the Subsection V cyanobacteria.". BMC Genomics 16 (2015): 669. https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-1855-z.
    Open access • Published • 10.1186/s12864-015-1855-z
  34. Micallef, M.L.; D'Agostino, P.M.; Al-Sinawi, B.; Neilan, B.A.; Moffitt, M.C.. "Exploring cyanobacterial genomes for natural product biosynthesis pathways". Marine Genomics 21 (2015): 1-12. https://www.sciencedirect.com/science/article/abs/pii/S1874778714001573?via%3Dihub.
    Published • 10.1016/j.margen.2014.11.009
  35. D'Agostino, P.M.; Song, X.; Neilan, B.A.; Moffitt, M.C.. "Comparative proteomics reveals that a saxitoxin-producing and a nontoxic strain of Anabaena circinalis are two different ecotypes". Journal of Proteome Research 13 3 (2014): 1474-1484. https://pubs.acs.org/doi/10.1021/pr401007k.
    Published • 10.1021/pr401007k
  36. Wiese, Maria; D’Agostino, Paul M.; Mihali, Troco K.; Moffitt, Michelle C.; Neilan, Brett A.. "Neurotoxic Alkaloids: Saxitoxin and Its Analogs". Marine Drugs 8 7 (2010): 2185-2211. https://www.mdpi.com/1660-3397/8/7/2185.
    Open access • Published • 10.3390/md8072185
Thesis / Dissertation
  1. DAgostino, Paul. "Molecular investigations of a saxitoxin-producing strain and a non-toxic strain of Anabaena circinalis". PhD, Western Sydney University, 2014.
  2. DAgostino, Paul. "Characterisation of the gene cluster responsible for the anti-cancer compound hapalosin". Master, Western Sydney University, 2008.
Working paper
  1. Eusebio, Nadia; Castelo -Branco, Raquel; Sousa, Diana; Preto, Marco; D'Agostino, Paul M.; Gulder, Tobias; Leão, Pedro. Corresponding author: Leão, Pedro. 2022. "Discovery and heterologous expression of microginins from Microcystis aeruginosa LEGE 91341". https://chemrxiv.org/engage/chemrxiv/article-details/622700285f1d9a40aeb4944d.
    10.26434/chemrxiv-2022-7bsz1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024 Direct Pathway Cloning (DiPaC) towards the efficient capture and expression of diverse cyanobacterial biosynthetic gene clusters Matthias Schleiden Institute Invited Speaker
Friedrich Schiller University Jena, (Jena, Germany)
2023 Direct Pathway Cloning (DiPaC) towards the efficient capture and expression of diverse cyanobacterial biosynthetic gene clusters BlueBio4Future Training Courses
CIIMAR (Porto, Portugal)
2021 Applying Direct Pathway Cloning (DiPaC) Towards the Capture and Expression of Cyanobacterial Biosynthetic Gene Clusters Cyano Online Seminar Series
2021 Applying Direct Pathway Cloning (DiPaC) Towards the Capture and Expression of Cyanobacterial Biosynthetic Gene Clusters Wawrick Seminar Series
2019 Direct Pathway Cloning (DiPaC) in the Hunt for Novel (Bio-)Chemistry Cluster Meeting: EU Action Plan against Antimicrobial Resistance
(Spain)