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Ana Luísa Graça is a Junior Researcher at i3S - Instituto de Investigação e Inovação em Saúde. With over 6 years of experience in academia, she has actively participated in significant international projects, focusing on innovative approaches in Life Sciences, Tissue Engineering, and Biomaterials. As an active member of the scientific community, she was also a member of several conference organizing committees. Ana Luísa Graça holds a degree in Genetics and Biotechnology from the University of Trás-os-Montes e Alto Douro and a master's in Molecular Biomedicine from the University of Aveiro. She holds a PhD in Tissue Engineering, Regenerative Medicine, and Stem Cells from the University of Minho, conducting her research at the 3B’s Research Group in collaboration with the University of Wuerzburg.
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Identification

Personal identification

Full name
Ana Luísa Ferreira Graça

Citation names

  • Graça, Ana
  • Graça, Ana Luísa
  • Graça, Ana L.

Author identifiers

Ciência ID
EF10-B08D-E965
ORCID iD
0000-0002-4338-9525

Email addresses

  • agraca@i3s.up.pt (Professional)

Addresses

  • i3S - Instituto de Investigação e Inovação em Saúde - Rua Alfredo Allen 208 , 4200-135, Porto, Porto, Portugal (Professional)

Knowledge fields

  • Natural sciences - Biological Sciences - Cell Biology
  • Engineering and Technology - Materials Engineering
  • Medical and Health Sciences - Medical Biotechnology - Biomaterials
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Elementary (A2) Upper intermediate (B2) Beginner (A1) Upper intermediate (B2) Beginner (A1)
Education
Degree Classification
2017 - 2023
Concluded
 Doutoramento em Engenharia de Tecidos, Medicina Regenerativa & Células Estaminais (Doutoramento)
Universidade do Minho Instituto de Investigação em Biomateriais Biodegradáveis e Biomiméticos, Portugal
"Human Blood-derived Extracellular Vesicles in Tendon Tissue Engineering and Regenerative Medicine Applications" (THESIS/DISSERTATION)
 Muito Bom (Maximum Grade)
2014 - 2016
Concluded
 Mestrado em Biomedicina Molecular (Mestrado)
Universidade de Aveiro, Portugal
"Predictors of aging and potential of FTIR to detect protein aggregates" (THESIS/DISSERTATION)
 17
2011 - 2014
Concluded
 Genética e Biotecnologia (Licenciatura)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
"Análise do gene SERPING1 em Angioedema Hereditário" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2024 - Current Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Others

Category
Host institution 		Employer
2017/09/01 - 2023/12/21 Doctoral Program in Tissue Engineering, Regenerative Medicine and Stem Cells (TERM&SC) Biomaterials Biodegradables and Biomimetics, Portugal
2023/06 - 2023/09 Guest Scientist Julius-Maximilians-Universität Würzburg, Germany
Julius-Maximilians-Universität Würzburg, Germany
2022/03 - 2022/06 Visiting PhD Student Julius-Maximilians-Universität Würzburg, Germany
Julius-Maximilians-Universität Würzburg, Germany
2014/09/01 - 2016/12/13 Master Degree: Molecular Biomedicine; Thesis: Predictors of Aging and Potential of FTIR to Detect Protein Aggregates Universidade de Aveiro, Portugal
2011/09/01 - 2014/06/30 Degree: Genetics and Biotechnology; Report: Análise do gene SERPING1 em Angioedema Hereditário Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
Projects

Grant

Designation Funders
2017/09/01 - 2022/07/31 Bolsa de Doutoramento
PD/BD/135255/2017 and COVID/BD/152017/2021
PhD Student Fellow
Universidade do Minho Instituto de Investigação em Biomateriais Biodegradáveis e Biomiméticos, Portugal
Concluded

Contract

Designation Funders
2024 - Current FibroSkin - FibroSkin – Uncovering biomechanical drivers in skin fibrosis to engineer a novel biomimetic 3D tissue model
2022.06048.PTDC
Post-doc
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/05/01 - 2023/10/31 Magnetically Assisted Tissue Engineering Technologies for Tendon Regeneration
772817
10.3030/772817
PhD Student
Universidade do Minho Instituto de Investigação em Biomateriais Biodegradáveis e Biomiméticos, Portugal
 European Commission
Concluded
2018/10/01 - 2022/06/30 Overcoming specific weaknesses in tendon biology to design advanced regenerative therapies
810850
10.3030/810850
PhD Student
Universidade do Minho Instituto de Investigação em Biomateriais Biodegradáveis e Biomiméticos, Portugal
 European Commission
Concluded
Outputs

Publications

Book chapter
  1. Graça, Ana Luísa; Bagur-Cardona, Sara; Stiliyanov-Atanasov, Kristiyan; Gomes, Manuela E.; Gomez-Florit, Manuel. "Cell-Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine". In Handbook of the Extracellular Matrix, 1-33. Springer International Publishing, 2023.
    10.1007/978-3-030-92090-6_34-1
  2. Graça, Ana Luísa; Gomez-Florit, Manuel; Gomes, Manuela Estima; Docheva, Denitsa. "Tendon Aging". In Biochemistry and Cell Biology of Ageing: Part IV, Clinical Science, 121-147. Springer International Publishing, 2023.
    10.1007/978-3-031-26576-1_7
Conference abstract
  1. Graça, Ana Luísa; Rui M A Domingues; Denitsa Docheva; Manuel Gomez-Florit; Manuela E Gomes. "Platelet-derived Extracellular Vesicles Promote Stem Cells Tenogenic Commitment in a Bioengineered Tendon 3D Model". Paper presented in 31st Annual Meeting of the European Orthopaedic Research Society (EORS), 2024.
  2. Graça, Ana Luísa; Marcia T Rodrigues; Rui M A Domingues; Manuela E Gomes; Manuel Gomez-Florit. "Polarized Macrophage-derived Extracellular Vesicles as Potential Mediators of Tendon Repair". Paper presented in 31st Annual Meeting of the European Orthopaedic Research Society (EORS), 2024.
  3. Graça, Ana; Gomez-Florit, Manuel; Marcia T. Rodrigues; Rui L. Reis; Manuela E. Gomes. "Platelet Lysate Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications". Paper presented in TERMIS-EU 2020, Manchester, 2020.
    Published
Conference poster
  1. Rafaela Presa; Luís B. Bebiano; Graça, Ana L.; Rita Valença Filipe; Rúben F. Pereira. "Mechanical characterization of human skin to guide the design of hydrogels for in vitro skin modeling". Paper presented in 53rd Annual ESDR Meeting, 2024.
  2. Graça, Ana L.; Domingues, R.M.A.; Gomez-Florit, M.; Gomes, M.E.. "Platelet-derived Extracellular Vesicles Promote Stem Cells Tenogenic Commitment in a Bioengineered Tendon 3D Model". Paper presented in REMIX Workshop, 2023.
  3. Graça, Ana L.; Domingues, R.M.A.; Calejo, I.; Gomez-Florit, M.; Gomes, M.E.. "Platelet-derived Extracellular Vesicles Show Therapeutic Effects on a 3D Tendon Disease Model 32nd Annual Conference of the European Society for Biomaterials.". Paper presented in 32nd Annual Conference of the European Society for Biomaterials, 2022.
  4. Graça, Ana Luísa; Domingues, Rui M. A.; Calejo, Isabel; Reis, Rui L.; Gomez-Florit, Manuel; Manuela E. Gomes. "Platelet-derived Extracellular Vesicles Show Therapeutic Effects on a 3D Tendon Disease Model". Paper presented in Third Achilles Workshop, 2021.
  5. Graça, Ana; Manuel Gomez-Florit; Márcia T. Rodrigues; Rui L. Reis; Manuela E. Gomes. "Platelet Lysate Derived Extracellular Vesicles for Tissue Engineering and Regenerative Medicine Applications". Paper presented in Second Achilles Conference, 2019.
  6. Graça, Ana; Manuel Gomez-Florit; Rui L. Reis; Manuela E. Gomes. "Proteomic Analysis of Platelet Lysate Derived Extracellular Vesicles". Paper presented in 1st Discoveries Forum on Regenerative and Precision Medicine, 2019.
  7. Graça, Ana; Manuel Gomez-Florit; Rui L. Reis; Manuela E. Gomes. "Proteomic Analysis of Platelet Lysate-Derives Extracellular Vesicles". Paper presented in Frist Achilles Conference, 2019.
  8. Graça, Ana; Manuel Gomez-Florit; Márcia T. Rodrigues; Pedro S. Babo; Rui L. Reis; Manuela E. Gomes. "Isolation and Characterization of Platelet Lysate Derived Exosomes Isolation for Tissue Engineering and Regenerative Medicine Applications". Paper presented in Chem2Nature Final Conference, 2018.
  9. Graça, Ana; Manuel Gomez-Florit; Pedro S. Babo; Rui L. Reis; Manuela E. Gomes. "Optimization of Platelet Lysate Derived Exosomes Isolation for Tissue Engineering and Regenerative Medicine Applications". Paper presented in Chem2Nature Summer School, 2018.
  10. Sandra Magalhães; Graça, Ana; Joana Tavares; Manuel A. S. Santos; Ivonne Delgadillo; Brian Goodfellow; Alexandra nunes. "Identification of protein aggregation in saccharomyces cerevisiae using FTIR and NMR spectroscopy". Paper presented in Jornadas do CICECO, 2018.
  11. Manuel Gomez-Florit; Graça, Ana; Pedro S. Babo; Rui L. Reis; Manuela E. Gomes. "Optimization of Platelet Lysate Derived Exosomes Isolation for Tissue Engineering and Regenerative Medicine Applications". Paper presented in European Society for Biomaterials Annual Meeting, 2018.
  12. Graça, Ana Luísa; Gomez-Florit, Manuel; Rodrigues, Márcia T.; Babo, Pedro; Reis, Rui L.; Gomes. Manuela E.. "Isolation and characterization of platelet lysate-derived exosomes for future tissue engineering and regenerative medicine applications". Paper presented in Chem2Nature2018, Guimaraes, 2018.
Journal article
  1. Graça, Ana Luísa; Kroner-Weigl, Niklas; Reyes Alcaraz, Viviana; Müller-Deubert, Sigrid; Rudert, Maximilian; Docheva, Denitsa. "Demonstration of Self-Assembled Cell Sheet Culture and Manual Generation of a 3D Tendon/Ligament-Like Organoid by using Human Dermal Fibroblasts". Journal of Visualized Experiments 208 (2024): http://dx.doi.org/10.3791/66047.
    10.3791/66047
  2. Ana L. Graça; Rui M. A. Domingues; Manuel Gomez-Florit; Manuela E. Gomes. "Platelet-Derived Extracellular Vesicles Promote Tenogenic Differentiation of Stem Cells on Bioengineered Living Fibers". International Journal of Molecular Sciences (2023): https://doi.org/10.3390/ijms24043516.
    10.3390/ijms24043516
  3. Ana L. Graça; Rui M. A. Domingues; Isabel Calejo; Manuel Gómez-Florit; Manuela E. Gomes. "Therapeutic Effects of Platelet-Derived Extracellular Vesicles in a Bioengineered Tendon Disease Model". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms23062948.
    10.3390/ijms23062948
  4. Ana L. Graça; Manuel Gómez-Florit; Hugo Osório; Márcia T. Rodrigues; Rui M. A. Domingues; Rui L. Reis; Manuela E. Gomes. "Controlling the fate of regenerative cells with engineered platelet-derived extracellular vesicles". Nanoscale (2022): https://doi.org/10.1039/D1NR08108J.
    10.1039/D1NR08108J
  5. Gomez-Florit, Manuel; Pardo, Alberto; Domingues, Rui M. A.; Graça, Ana L.; Babo, Pedro S.; Reis, Rui L.; Gomes, Manuela E.. "Natural-Based Hydrogels for Tissue Engineering Applications". Molecules 25 24 (2020): 5858. http://dx.doi.org/10.3390/molecules25245858.
    Published • 10.3390/molecules25245858
  6. Magalhães, Sandra; Graça, Ana; Tavares, Joana; Santos, Manuel A. S.; Delgadillo, Ivonne; Nunes, Alexandra. "Saccharomyces cerevisiae as a Model to Confirm the Ability of FTIR to Evaluate the Presence of Protein Aggregates". Spectral Analysis Review 06 01 (2018): 1-11. http://dx.doi.org/10.4236/sar.2018.61001.
    10.4236/sar.2018.61001
  7. Graça, Ana; Magalhães, Sandra; Nunes, Alexandra. "Biological Predictors of Aging and Potential of FTIR to Study Age-related Diseases and Aging Metabolic Fingerprint". Current Metabolomics 5 2 (2017): http://dx.doi.org/10.2174/2213235x04666161107150017.
    10.2174/2213235x04666161107150017
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023 Platelet-derived Extracellular Vesicles: a revolutionary cue of tendon repair and regeneration 31st Annual Meeting of the European Orthopaedic Research Society (EORS)
(Porto, Portugal)
2022 Platelet-derived Extracellular Vesicles Show Therapeutic Effects on a 3D Tendon Disease Model TERMIS-EU 2022
(Cracóvia, Poland)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023 - 2023 31st Annual Meeting of the European Orthopaedic Research Society (EORS) - Chair and New Investigator and Social Media Committee (2023 - 2023) Universidade do Minho Instituto de Investigação em Biomateriais Biodegradáveis e Biomiméticos, Portugal
2022 - 2022 Final Achilles Conference - Member of the Organizing Team (2022 - 2022) Universidade do Minho Instituto de Investigação em Biomateriais Biodegradáveis e Biomiméticos, Portugal
2021/10/25 - 2021/10/27 Third Achilles Workshop - Member of the Organizing Team (2021/10/25 - 2021/10/27)
Conference (Member of the Organising Committee)
 Biomaterials Biodegradables and Biomimetics, Portugal
2019/11 - 2019/11 Second Achilles Conferences - Member of the Organizing Team (2019/11 - 2019/11)
Conference (Member of the Organising Committee)
 Biomaterials Biodegradables and Biomimetics, Portugal
2019/06 - 2019/06 Frist Achilles Conference - Member of the Organizing Team (2019/06 - 2019/06)
Conference (Member of the Organising Committee)
 Biomaterials Biodegradables and Biomimetics, Portugal

Association member

Society Organization name Role
2024 - Current Portuguese Network on Extracellular Vesicles (PNEV)
2017 - 2019 PhDynamics Initiative

Mentoring / Tutoring

Topic Student name
2024/03 - 2024/10 3D-Printed Microfiber-Reinforced Hydrogels to Modulate Skin Repair and Fibrosis Solange Soares