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Identification

Personal identification

Full name
António José Freitas Duarte

Citation names

  • Duarte, António

Author identifiers

Ciência ID
EF13-C5B0-2323
ORCID iD
0000-0002-9255-3635

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Intermediate (B1) Advanced (C1)
French Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Spanish; Castilian Beginner (A1) Intermediate (B1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2019 - 2019/07/11
Concluded
 Habilitation in Veterinary Sciences (Agregação em Ciências Veterinárias) (Título de Agregado)
Major in Veterinary Sciences (Ciências Veterinárias)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
"“Regulation of Insulin-like growth factor II expression by the Wilms´tumour suppressor protein”" (THESIS/DISSERTATION)
1997
Concluded
 DPhil (Doutoramento)
Major in Mammalian Molecular Genetics
University of Oxford Wolfson College, United Kingdom
"Regulation of Insulin-like growth factor II expression by the Wilms´ tumour suppressor protein WT1 " (THESIS/DISSERTATION)
 ---
1993
Concluded
 MSc in Agricultural Biotechnology (Mestrado)
Newcastle University, United Kingdom
"Analysis of gastrin gene transcription in the rat pancreatic tumour cell line AR4-2J" (THESIS/DISSERTATION)
 ---
1992
Concluded
 Licenciatura em Medicina Veterinária (Licenciatura)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
"n/a" (THESIS/DISSERTATION)
 15 valores
Affiliation

Science

Category
Host institution 		Employer
2006 - 2015 Visiting Researcher (Research) Instituto Gulbenkian de Ciência, Portugal
1998 - 2001 Postdoc (Research) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2007/09/01 - Current Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2001 - 2007 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Positions / Appointments

Category
Host institution 		Employer
2016 - Current Conselho científico/técnico-científico ou orgão correspondente Universidade de Lisboa, Portugal
2016 - Current Coordenação ou direção de centro de investigação, departamento ou equivalente Universidade de Lisboa, Portugal

Others

Category
Host institution 		Employer
2008/02/01 - 2010/07/05 CEO, responsible for the production of the first Portuguese made biopharmaceutical, a conjugated vaccine against typhoid fever developed by the Novartis Vaccines Institute of Global Health. Genibet Biopharmaceuticals, Portugal
2008/02/01 - 2010/07/05 Chief Executive Officer of Genibet Biopharmaceuticals, leading the process of GMP certification of the first biopharmaceutical production unit in Portugal. Genibet Biopharmaceuticals, Portugal
1998 - 2001 Postdoctoral fellow Fundação para a Ciência e a Tecnologia, Portugal
1993 - 1997 PhD student Fundação para a Ciência e a Tecnologia, Portugal
1992 - 1993 MSc student Fundação para a Ciência e a Tecnologia, Portugal
Projects

Grant

Designation Funders
1999 - 2002 PRAXIS P/CVT/11187/1998 Regulation of muscle development in mammals by a new transcription factor with a bHLH domain and its interaction with the Notch signalling system
P/CVT/11187/1998
Principal investigator
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
1999 - 2002 PRAXIS P/CVT/11187/1998 Regulation of muscle development in mammals by a new transcription factor with a bHLH domain and its interaction with the Notch signalling system
P/CVT/11187/1998
 Fundação para a Ciência e a Tecnologia
Outputs

Publications

Journal article
  1. Pâmela Cristina Lopes Gurgel Valente; Maria Conceição Peleteiro; Sandra Carvalho; Rodolfo Oliveira Leal; Constança Pomba; António Duarte; Jorge Correia. "Co-Expression of T- and B-Cell Markers in a Canine Intestinal Lymphoma: A Case Report". Animals (2022): https://doi.org/10.3390/ani12243531.
    10.3390/ani12243531
  2. Alexandre Trindade; António Duarte. "Notch Signaling Function in the Angiocrine Regulation of Tumor Development". Cells 9 11 (2020): 2467-2467. https://doi.org/10.3390/cells9112467.
    10.3390/cells9112467
  3. Liliana Mendonça; Alexandre Trindade; Catarina Carvalho; Jorge Correia; Marina Badenes; Joana Gigante; António Duarte. "Metastasis is impaired by endothelial-specific Dll4 loss-of-function through inhibition of epithelial-to-mesenchymal transition and reduction of cancer stem cells and circulating tumor cells". Clinical & Experimental Metastasis 36 4 (2019): 365-380. https://doi.org/10.1007/s10585-019-09973-2.
    10.1007/s10585-019-09973-2
  4. Marina Badenes; Alexandre Trindade; Hugo Pissarra; Luís Lopes-da-Costa; António Duarte. "Delta-like 4/Notch signaling promotes Apc Min/+ tumor initiation through angiogenic and non-angiogenic related mechanisms". BMC Cancer 17 1 (2017): https://doi.org/10.1186%2Fs12885-016-3036-0.
    10.1186/s12885-016-3036-0
  5. Alexandre Trindade; Dusan Djokovic; Joana Gigante; Liliana Mendonça; António Duarte. "Endothelial Dll4 overexpression reduces vascular response and inhibits tumor growth and metastasization in vivo". BMC Cancer 17 1 (2017): https://doi.org/10.1186%2Fs12885-017-3171-2.
    10.1186/s12885-017-3171-2
  6. Pedrosa AR; Graça JL; Carvalho S; Peleteiro MC; Duarte A; Trindade A. "Notch signaling dynamics in the adult healthy prostate and in prostatic tumor development.". (2015): http://europepmc.org/abstract/med/26419726.
    10.1002/pros.23102
  7. Pedrosa AR; Trindade A; Carvalho C; Graça J; Carvalho S; Peleteiro MC; Adams RH; Duarte A. "Endothelial Jagged1 promotes solid tumor growth through both pro-angiogenic and angiocrine functions.". (2015): http://europepmc.org/abstract/med/26213336.
  8. Pedrosa AR; Trindade A; Fernandes AC; Carvalho C; Gigante J; Tavares AT; Diéguez-Hurtado R; et al. "Endothelial JAGGED1 antagonizes dll4 regulation of endothelial branching and promotes vascular maturation downstream of dll4/notch1.". (2015): http://europepmc.org/abstract/med/25767274.
    10.1161/ATVBAHA.114.304741
  9. Murta D; Batista M; Trindade A; Silva E; Mateus L; Duarte A; Lopes-da-Costa L. "Dynamics of Notch signalling in the mouse oviduct and uterus during the oestrous cycle.". (2015): http://europepmc.org/abstract/med/25940784.
  10. Basto AP; Badenes M; Almeida SC; Martins C; Duarte A; Santos DM; Leitão A. "Immune response profile elicited by the model antigen ovalbumin expressed in fusion with the bacterial OprI lipoprotein.". (2015): http://europepmc.org/abstract/med/25467796.
    10.1016/j.molimm.2014.10.020
  11. Djokovic D; Trindade A; Gigante J; Pinho M; Harris AL; Duarte A. "Incomplete Dll4/Notch signaling inhibition promotes functional angiogenesis supporting the growth of skin papillomas.". (2015): http://europepmc.org/abstract/med/26314892.
    10.1186/s12885-015-1605-2
  12. Jahnsen ED; Trindade A; Zaun HC; Lehoux S; Duarte A; Jones EA. "Notch1 is pan-endothelial at the onset of flow and regulated by flow.". (2015): http://europepmc.org/abstract/med/25830332.
    10.1371/journal.pone.0122622
  13. Murta D; Batista M; Silva E; Trindade A; Mateus L; Duarte A; Lopes-da-Costa L. "Differential expression of Notch component and effector genes during ovarian follicle and corpus luteum development during the oestrous cycle.". (2014): http://europepmc.org/abstract/med/24695060.
  14. Murta D; Batista M; Trindade A; Silva E; Henrique D; Duarte A; Lopes-da-Costa L. "In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse.". (2014): http://europepmc.org/abstract/med/25412258.
    10.1371/journal.pone.0113365
  15. Camelo, S.; Raoul, W.; Lavalette, S.; Calippe, B.; Cristofaro, B.; Levy, O.; Houssier, M.; et al. "Erratum: Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages (Angiogenesis (2012) 16 (609-622))". Angiogenesis 16 2 (2013): 479-480. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879479166&partnerID=MN8TOARS.
    10.1007/s10456-012-9331-8
  16. Cristofaro, B.; Shi, Y.; Faria, M.; Suchting, S.; Leroyer, A.S.; Trindade, A.; Duarte, A.; et al. "Dll4-notch signaling determines the formation of native arterial collateral networks and arterial function in mouse ischemia models". Development (Cambridge) 140 8 (2013): 1720-1729. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875442488&partnerID=MN8TOARS.
    10.1242/dev.092304
  17. Murta, D.; Batista, M.; Silva, E.; Trindade, A.; Henrique, D.; Duarte, A.; Lopes-da-Costa, L.. "Dynamics of Notch Pathway Expression during Mouse Testis Post-Natal Development and along the Spermatogenic Cycle". PLoS ONE 8 8 (2013): http://www.scopus.com/inward/record.url?eid=2-s2.0-84883404801&partnerID=MN8TOARS.
    10.1371/journal.pone.0072767
  18. Trindade, A.; Djokovic, D.; Gigante, J.; Badenes, M.; Pedrosa, A.-R.; Fernandes, A.-C.; Lopes-da-Costa, L.; et al. "Low-Dosage inhibition of DLL4 signaling promotes wound healing by inducing functional Neo-Angiogenesis". PLoS ONE 7 1 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855938803&partnerID=MN8TOARS.
    10.1371/journal.pone.0029863
  19. Liu, R.; Trindade, A.; Sun, Z.; Kumar, R.; Weaver, F.A.; Krasnoperov, V.; Naga, K.; Duarte, A.; Gill, P.S.. "Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues". Biochemical and Biophysical Research Communications 418 1 (2012): 173-179. http://www.scopus.com/inward/record.url?eid=2-s2.0-84863403912&partnerID=MN8TOARS.
    10.1016/j.bbrc.2012.01.002
  20. Larrivée, B.; Prahst, C.; Gordon, E.; del Toro, R.; Mathivet, T.; Duarte, A.; Simons, M.; Eichmann, A.. "ALK1 Signaling Inhibits Angiogenesis by Cooperating with the Notch Pathway". Developmental Cell 22 3 (2012): 489-500. http://www.scopus.com/inward/record.url?eid=2-s2.0-84858176226&partnerID=MN8TOARS.
    10.1016/j.devcel.2012.02.005
  21. Benedito, R.; Rocha, S.F.; Woeste, M.; Zamykal, M.; Radtke, F.; Casanovas, O.; Duarte, A.; Pytowski, B.; Adams, R.H.. "Notch-dependent VEGFR3 upregulation allows angiogenesis without VEGF-VEGFR2 signalling". Nature 484 7392 (2012): 110-114. http://www.scopus.com/inward/record.url?eid=2-s2.0-84859453770&partnerID=MN8TOARS.
    10.1038/nature10908
  22. Laranjeiro, R.; Alcobia, I.; Neves, H.; Gomes, A.C.; Saavedra, P.; Carvalho, C.C.; Duarte, A.; Cidadão, A.; Parreira, L.. "The notch ligand delta-like 4 regulates multiple stages of early hemato-vascular development". PLoS ONE 7 4 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84859710001&partnerID=MN8TOARS.
    10.1371/journal.pone.0034553
  23. Camelo, S.; Raoul, W.; Lavalette, S.; Calippe, B.; Cristofaro, B.; Levy, O.; Houssier, M.; et al. "Delta-like 4 inhibits choroidal neovascularization despite opposing effects on vascular endothelium and macrophages". Angiogenesis 15 4 (2012): 609-622. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875035470&partnerID=MN8TOARS.
    10.1007/s10456-012-9290-0
  24. Remédio, L.; Carvalho, T.; Caiado, F.; Bastos-Carvalho, A.; Martins, D.; Duarte, A.; Yagita, H.; Dias, S.. "Context- and Cell-Dependent Effects of Delta-Like 4 Targeting in the Bone Marrow Microenvironment". PLoS ONE 7 12 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84871412471&partnerID=MN8TOARS.
    10.1371/journal.pone.0052450
  25. Real, C.; Remédio, L.; Caiado, F.; Igreja, C.; Borges, C.; Trindade, A.; Pinto-do-Ó, P.; et al. "Bone marrow-derived endothelial progenitors expressing delta-like 4 (Dll4) regulate tumor angiogenesis". PLoS ONE 6 4 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79953685607&partnerID=MN8TOARS.
    10.1371/journal.pone.0018323
  26. Duarte, António. "Lineage-instructive function of C/EBPa in multipotent hematopoietic cells and early thymic progenitors". Blood (2010): http://dx.doi.org/10.1182/blood-2010-03-275404.
    10.1182/blood-2010-03-275404
  27. Del Toro, R.; Prahst, C.; Mathivet, T.; Siegfried, G.; Kaminker, J.S.; Larrivee, B.; Breant, C.; et al. "Identification and functional analysis of endothelial tip cell-enriched genes". Blood 116 19 (2010): 4025-4033. http://www.scopus.com/inward/record.url?eid=2-s2.0-78149422176&partnerID=MN8TOARS.
    10.1182/blood-2010-02-270819
  28. Djokovic, D.; Trindade, A.; Gigante, J.; Badenes, M.; Silva, L.; Liu, R.; Li, X.; et al. "Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis". BMC Cancer 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-78549253191&partnerID=MN8TOARS.
    10.1186/1471-2407-10-641
  29. Trindade, A.; Kumar, S.R.; Scehnet, J.S.; Lopes-Da-costa, L.; Becker, J.; Jiang, W.; Liu, R.; Gill, P.S.; Duarte, A.. "Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos". Blood 112 5 (2008): 1720-1729. http://www.scopus.com/inward/record.url?eid=2-s2.0-52649121738&partnerID=MN8TOARS.
    10.1182/blood-2007-09-112748
  30. Koch, U.; Fiorini, E.; Benedito, R.; Besseyrias, V.; Schuster-Gossler, K.; Pierres, M.; Manley, N.R.; et al. "Delta-like 4 is the essential, nonredundant ligand for Notchl during thymic T cell lineage commitment". Journal of Experimental Medicine 205 11 (2008): 2515-2523. http://www.scopus.com/inward/record.url?eid=2-s2.0-58149151302&partnerID=MN8TOARS.
    10.1084/jem.20080829
  31. Benedito, R.; Trindade, A.; Hirashima, M.; Henrique, D.; Da Costa, L.L.; Rossant, J.; Gill, P.S.; Duarte, A.. "Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli". BMC Developmental Biology 8 (2008): http://www.scopus.com/inward/record.url?eid=2-s2.0-59649084735&partnerID=MN8TOARS.
    10.1186/1471-213X-8-117
  32. Tammela, T.; Zarkada, G.; Wallgard, E.; Murtomäki, A.; Suchting, S.; Wirzenius, M.; Waltari, M.; et al. "Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation". Nature 454 7204 (2008): 656-660. http://www.scopus.com/inward/record.url?eid=2-s2.0-48349129069&partnerID=MN8TOARS.
    10.1038/nature07083
  33. Suchting, S.; Freitas, C.; Le Noble, F.; Benedito, R.; Bréant, C.; Duarte, A.; Eichmann, A.. "The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching". Proceedings of the National Academy of Sciences of the United States of America 104 9 (2007): 3225-3230. http://www.scopus.com/inward/record.url?eid=2-s2.0-33847607880&partnerID=MN8TOARS.
    10.1073/pnas.0611177104
  34. Lahiri, D.; Button, J.R.; Duarte, A.; Moorwood, K.; Graham, C.F.; Ward, A.. "Nephropathy and defective spermatogenesis in mice transgenic for a single isoform of the Wilms' tumour suppressor protein, WT1-KTS, together with one disrupted Wt1 allele". Molecular Reproduction and Development 74 3 (2007): 300-311. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846441242&partnerID=MN8TOARS.
    10.1002/mrd.20491
  35. Scehnet, J.S.; Jiang, W.; Kumar, S.R.; Krasnoperov, V.; Trindade, A.; Benedito, R.; Djokovic, D.; et al. "Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion". Blood 109 11 (2007): 4753-4760. http://www.scopus.com/inward/record.url?eid=2-s2.0-34247479498&partnerID=MN8TOARS.
    10.1182/blood-2006-12-063933
  36. Suchting, S.; Freitas, C.; Le Noble, F.; Benedito, R.; Bréant, C.; Duarte, A.; Eichmann, A.. "Negative regulators of vessel patterning". Novartis Foundation Symposium 283 (2007): 77-80. http://www.scopus.com/inward/record.url?eid=2-s2.0-40949110123&partnerID=MN8TOARS.
  37. Seo, S.; Fujita, H.; Nakano, A.; Kang, M.; Duarte, A.; Kume, T.. "The forkhead transcription factors, Foxc1 and Foxc2, are required for arterial specification and lymphatic sprouting during vascular development". Developmental Biology 294 2 (2006): 458-470. http://www.scopus.com/inward/record.url?eid=2-s2.0-33745099879&partnerID=MN8TOARS.
    10.1016/j.ydbio.2006.03.035
  38. Benedito, R.; Duarte, A.. "Expression of Dll4 during mouse embryogenesis suggests multiple developmental roles". Gene Expression Patterns 5 6 (2005): 750-755. http://www.scopus.com/inward/record.url?eid=2-s2.0-21744442626&partnerID=MN8TOARS.
    10.1016/j.modgep.2005.04.004
  39. Duarte, A.; Hirashima, M.; Benedito, R.; Trindade, A.; Diniz, P.; Bekman, E.; Costa, L.; Henrique, D.; Rossant, J.. "Dosage-sensitive requirement for mouse Dll4 in artery development". Genes and Development 18 20 (2004): 2474-2478. http://www.scopus.com/inward/record.url?eid=2-s2.0-5444261424&partnerID=MN8TOARS.
    10.1101/gad.1239004
  40. Campos, L.S.; Duarte, A.J.; Branco, T.; Henrique, D.. "mDll1 and mDll3 expression in the developing mouse brain: Role in the establishment of the early cortex". Journal of Neuroscience Research 64 6 (2001): 590-598. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035877174&partnerID=MN8TOARS.
    10.1002/jnr.1111
  41. Pissarra, L.; Henrique, D.; Duarte, A.. "Expression of hes6, a new member of the Hairy/Enhancer-of-split family, in mouse development". Mechanisms of Development 95 1-2 (2000): 275-278. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034235253&partnerID=MN8TOARS.
    10.1016/S0925-4773(00)00348-8
  42. Duarte, A.; Caricasole, A.; Graham, C.F.; Ward, A.. "Wilms' tumour suppressor protein isoforms have opposite effects on Igf2 expression in primary embryonic cells, independently of p53 genotype". British Journal of Cancer 77 2 (1998): 253-259. http://www.scopus.com/inward/record.url?eid=2-s2.0-0031964537&partnerID=MN8TOARS.
  43. Caricasole, A.; Duarte, A.; Larsson, S.H.; Hastie, N.D.; Little, M.; Holmes, G.; Todorov, I.; Ward, A.. "RNA binding by the Wilms tumor suppressor zinc finger proteins". Proceedings of the National Academy of Sciences of the United States of America 93 15 (1996): 7562-7566. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029839457&partnerID=MN8TOARS.
    10.1073/pnas.93.15.7562
  44. Little, M.H.; Holmes, G.; Pell, L.; Caricasole, A.; Duarte, A.; Law, M.; Ward, A.; Wainwright, B.. "A novel target for the Wilms' tumour suppressor protein (WT1) is bound by a unique combination of zinc fingers". Oncogene 13 7 (1996): 1461-1469. http://www.scopus.com/inward/record.url?eid=2-s2.0-0029826777&partnerID=MN8TOARS.
  45. Ward A; Pooler JA; Miyagawa K; Duarte A; Hastie ND; Caricasole A. "Repression of promoters for the mouse insulin-like growth factor II-encoding gene (Igf-2) by products of the Wilms' tumour suppressor gene wt1.". (1995): http://europepmc.org/abstract/med/8566784.
    10.1016/0378-1119(95)00645-1
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2016 - Current Utilização da reação em cadeia da polímerase para detecção de rearranjos do receptor de antigénio (PRRA) no diagnóstico e acompanhamento de cães com linfoma multicêntrico
Supervisor
 Ciências Veterinárias (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2011 - 2011 The Role of Endothelial DLL4 in Cancer Metastasis
Supervisor
 Ciências Veterinárias (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2009 - 2009 Utilização de murganhos no estudo de novos alvos da terapia oncológica anti-angiogénica
Supervisor
 Ciências Veterinárias (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2009 - 2009 The role of jagged 1 in adult angiogenesis and in solid tumor development
Supervisor
 Ciências Veterinárias (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2009 - 2009 In vivo evaluation of the role of Delta-like 4/Notch signaling in the development of intestinal tumors
Supervisor
 Ciências Veterinárias (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2008 - 2008 Estudo da Função do Gene Delta 4 na Regulação da Angiogénese
Supervisor
 Ciência e Tecnologia Animal (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2003 - 2003 Estudo de Gliomas Cerebrais no Cão, Padrões Imagiológicos, Estudo das Mutações de P53, Expressão dos Receptores do Factor de Crescimento Epidérmico (EGFR) e Marcadores Imunohistoquímicos
Co-supervisor
 Ciências Veterinárias (PhD)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal