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JOÃO NUNO MOREIRA RESEARCH ACTIVITY Scientific activity is focused on the design of lipid-based nanosystems for anticancer drug and nucleic acid targeted delivery, addressing the impact on the tumor microenvironment, at the cellular and molecular level, both in vitro and in animal models of cancer. With this, novel antitumor targeted strategies are expected to be generated against tumors associated with clear unmet medical needs. The goals of the group also point towards the identification and validation of target proteins overexpressed in tumors associated with clear unmet medical needs. Aiming at increasing the translational potential of the generated knowledge, the involvement of researchers from hospitals and clinicians is fostered. This is crucial to support the identified target proteins as markers for drug targeting, namely in patients-derived samples and thus validate the proposed targeting strategies. Has experience in coordination of funded research projects in several research projects, within academia as well as in collaboration with pharmaceutical industry. TRAINING (concluded) Has supervised 6 post-docs (including an ongoing Marie-Curie fellow), 15 PhD students (including a Marie-Curie student), 10 master students (with experimental work), 8 research fellows and 4 undergraduate students. He is co-editor of 2 books, co-author of 87 publications in peer-reviewed journals, 12 book chapters and 10 filed patents (3 of them have been granted in the United States and 2 in Europe, - and licensed to TREAT U, SA). Has lectured over 175 oral communications by invitation, among PhD and Master courses, as well as in national and international meetings. Has published in high impact journals such Nano Today (IF: 20.722), Biomaterials (IF: 10.273), Journal of Controlled Release (IF: 7.261), ACS Nano (IF: 12.033), Cancer Treatment Reviews (IF: 6.024), Accounts of Chemical Research (IF: 20.323) or Advanced Drug Delivery Reviews (IF: 15.038). One of the Lipid NanoParticles developed by João Nuno Moreira’s research group was awarded with the Orphan Drug Designation for the treatment of malignant pleural mesothelioma, by the European Medicines Agency (2017) and the Food and Drug Administration (2018). EDUCATIONAL BACKGROUND AND POSITIONS: Degree in Pharmaceutical Sciences (PharmD; University of Coimbra); MSc. in Cellular Biology (University of Coimbra); PhD in Pharmaceutical Technology (University of Coimbra/University of Alberta, Edmonton, Canada); Habilitation ("Agregação") in Pharmaceutical Technology (University of Coimbra). Associate Professor, with Tenure (Faculty of Pharmacy, University of Coimbra). AWARDS, MERITS AND OTHERS: Group Leader at CNC (Group of Tumor microenvironment and targeted medicines); President of the Spanish-Portuguese Local Chapter of the Controlled Release Society (Jan 2016 - Jan 2018); Member of the International Committee of the Controlled Release Society (2015/2016); Member of the Board of the Portuguese Association for Cancer Research (ASPIC) (2016 ¿ 2018); Research work on breast cancer, has been honored by the Portuguese Society of Senology (2012); Winner of the 2010 Education Innovation Awards within the scope of the MIT-Portugal program; Lecturer on the advanced course on Principles and Practice in Drug Development (at MIT, Boston, USA;); Co-founder of TREAT U, SA (www.treatu.pt), a spin-off from the University of Coimbra and CNC (2010); Expert reviewer for the European Medicines Agency (2019); PhD and Post-Doc fellowships (Portuguese Foundation for Science and Technology, including panel Coordinator in 2015) and grants from international funding agencies (EuroNanoMed ERA-Net Consortium; Netherlands Organization for Scientific Research; French National Research Agency, Israel Science Foundation, Dutch Cancer Society; COST Actions).
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Identification

Personal identification

Full name
João Nuno Sereno de Almeida Moreira

Citation names

  • Moreira, João Nuno

Author identifiers

Ciência ID
EF1B-FA3D-0787
ORCID iD
0000-0003-3449-0522

Email addresses

  • jmoreira@ff.uc.pt (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Medical Biotechnology - Health-Related Biotechnology
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
Education
Degree Classification
2007/03/19 - 2030/12/31
Ongoing
 Assistant Professor with Tenure (Outros)
Faculty of Pharmacy, University of Coimbra, Portugal
2014/01/16 - 2030
Ongoing
 Habilitation on Pharmaceutical Technology (Biotechnology) (Título de Agregado)
Major in Professor Agregado em Ciências Farmacêuticas, na especialidade de Tecnologia Farmacêutica
Faculty of Pharmacy, University of Coimbra, Portugal
"Sistemas de base nanotecnológica em oncologia: desafios e oportunidades" (THESIS/DISSERTATION)
 Approved by unanimity
2002/03/18
Concluded
 Ph D in Pharmacy, area of expertise Pharmaceutical Technology/Biotechnology (Doutoramento)
Faculty of Pharmacy, University of Coimbra, Portugal
"Targeting Stealth Liposomes to Human Small Cell Lung Cancer" (THESIS/DISSERTATION)
 Praise and Distinction by unanimit
1996 - 2000
Concluded
 Visiting graduate student (Outros)
Faculty of Medicine, University of Alberta, Canada
1995/04/28
Concluded
 Master on Cellular Biology (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Characterization of carboplati-containing liposomes coated with O-palmitoylpullulan" (THESIS/DISSERTATION)
 Very Good (highest classification)
1991/09/06
Concluded
 Degree on Pharmaceutical Sciences (Licenciatura)
Faculty of Pharmacy, University of Coimbra, Portugal
"n/a" (THESIS/DISSERTATION)
 15,3 (out of 20)
Affiliation

Science

Category
Host institution 		Employer
2005/09/01 - Current Researcher (Research) Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
2011 - 2018 Principal Investigator (Research) Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal

Teaching in Higher Education

Category
Host institution 		Employer
2002/03/19 - Current Assistant Professor (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1995/04/29 - 2002/03/17 Assistant (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1992/10/29 - 1995/04/28 Trainee Assistant (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
1991/11/08 - 1992/10/28 Tutor (University Teacher) Faculty of Pharmacy, University of Coimbra, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2010/01/29 - Current Co-founder of TREAT U, SA TREAT U, SA, Portugal
2005 - Current Group Leader (Tumor Microenvironment and Targeted Therapies) Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
Center for Neurosciences and Cell Biology (CNC), University of Coimbra, Portugal
Outputs

Publications

Book chapter
  1. Abreu, Teresa R.; Biscaia, Mariana; Gonçalves, Nélio; Fonseca, Nuno A.; Moreira, João Nuno. "In Vitro and In Vivo Tumor Models for the Evaluation of Anticancer Nanoparticles". In Advances in Experimental Medicine and Biology, 271-299. Springer International Publishing, 2021.
    10.1007/978-3-030-58174-9_12
  2. Ribeiro, Rita; Abreu, Teresa Raquel; Silva, Ana Catarina; Gonçalves, João; Moreira, João Nuno. "Insights on the Formulation of Recombinant Proteins". In Current Applications of Pharmaceutical Biotechnology. Advances in Biochemical Engineering/Biotechnology, 23-54. Springer International Publishing, 2020.
    10.1007/10_2019_119
  3. Silva, Ana Catarina; Costa, Cládia Pina; Almeida, Hugo; Moreira, João Nuno; Sousa Lobo, José Manuel. "Hormones, Blood Products, and Therapeutic Enzymes". In Current Applications of Pharmaceutical Biotechnology. Advances in Biochemical Engineering/Biotechnology., 115-153. Springer International Publishing, 2020.
    Published • 10.1007/10_2019_111
  4. Abreu, T. R.; Biscaia, M.; Gonçalves, N.; Fonseca, Nuno A.; Moreira, João Nuno. "In vitro and in vivo tumor models for the evaluation of anticancer nanoparticles". In Biomedicine for Cancer Therapy, edited by Hélder Santos; Flavia Fontana. Springer Nature, 2020.
    In press
  5. Silva, Ana Catarina; Moreira, João Nuno; Sousa Lobo, José Manuel. "Hematopoietic Growth Factors". In Encyclopedia of Molecular Pharmacology, 1-5. Springer International Publishing, 2020.
    10.1007/978-3-030-21573-6_72-1
  6. Cruz, Ana Filipa; Fonseca, Nuno A.; Gregório, Ana C.; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Moving Liposome Technology from the Bench to the Oncological Patient: Towards Performance-by-Design". In Particles and Nanoparticles in Pharmaceutical Products, edited by Merkus H.; Meesters G.; Oostra W., 171-211. Springer International Publishing, 2018.
    Published • 10.1007/978-3-319-94174-5_4
  7. Fonseca, Nuno A.; Lopes, Rui M.; Cruz, Ana F.; Gregório, Ana C.; Valério-Fernandes, Ângela; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Lipid-Based Nanosystems for the Delivery of siRNA: Challenges and Trends". In Handbook of Nanomaterials for Cancer Theranostics, edited by João Conde, 495-515. Elsevier, 2018.
    Published • 10.1016/b978-0-12-813339-2.00016-5
  8. Lopes, R.M.; Fonseca, N.A.; Cruz, A.F.; Gregório, A.C.; Valério-Fernandes, Â.; Moura, V.; Simões, S.; Moreira, J.N.. "Advances on nucleic acid delivery with nonviral vectors". In Bioinspired Materials for Medical Applications, edited by Lígia Rodrigues, 403-426. Elsevier, 2017.
    Published • 10.1016/b978-0-08-100741-9.00014-0
  9. Gomes-da-Silva, L.C.; Sérgio Simões; Moreira, João Nuno. "The use of liposomes for the systemic delivery of RNAi therapeutics aiming at cancer treatment". In Liposomal delivery systems - Advances and challenges, edited by Ryan De Vooght-Johnson, 105-119. Future Science, 2016.
    Published • 10.4155/fseb2013.14.182
  10. Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio. "Quimioterapia combinada no tratamento do cancro: princípios e estratégias nanotecnológicas de entrega de fármacos". In Biomateriais aplicados ao desenvolvimento de sistemas terapêuticos avançados, edited by H.C. De Sousa; M.E.M. Braga; A. Sosnik, 675-700. Imprensa da Universidade de Coimbra, 2015.
    10.14195/978-989-26-0881-5_17
  11. Catarina, Ana; João Nuno Moreira; Simoes, Sergio. "Combination Chemotherapy in Cancer: Principles, Evaluation and Drug Delivery Strategies". In Current Cancer Treatment - Novel Beyond Conventional Approaches, edited by Öner Özdemir. InTech, 2011.
    Published • 10.5772/22656
  12. Moreira, João Nuno. "Moura V, Gomes da Silva LC, Fonseca NA, Pedroso de Lima MC, Simões S, Moreira JN, Emerging targets and novel nanotechnology-based strategies: changing the treatment paradigm in oncology.". In Brain Cancer, Tumor Targeting and Cervical Cancer, Elena K. Salvatti (Ed.), Nova Science Publishers (2011). ISBN: 978-1-61122-738-3., 39-74. 2011.
    Published
  13. Moreira, João Nuno; Santos, A.; Bimbo, L.M.; Gomes da Silva, L. C.; Pedroso de Lima, M. C.; Simões, S.. "Gene silencing therapy in small cell lung cancer – which agents, targets, and delivery systems?". In Small-Cell Carcinomas: Causes, Diagnosis, and Treatment, edited by Jonathon G. Maldonado; Mikayla K. Cervantes, 1-51. Nova Science Publishers, 2009.
    Published
Conference abstract
  1. Abreu, TA; Godinho-Santos, A; Moreira, JN; Gonçalves, J. "P06.02 Anti-nucleolin CAR (chimeric antigen receptor)-T cell targeting triple-negative breast cancer – critical parameters in CAR-T cells generation". Paper presented in 9th Immunotherapy of Cancer Conference, Munich, 2022.
    Published • 10.1136/jitc-2022-itoc9.42
Conference paper
  1. Costa, Cláudia; Cunha, Sara; Peixoto, Andreia; Moreira, João Nuno; Sousa Lobo, José; Silva, Ana. "Application of the quality-by-design (QbD) approach to improve the nose-to-brain delivery of diazepam-loaded nanostructured lipid carriers (NLC)". 2020.
    https://doi.org/10.3390/IECP2020- 08658
  2. Chiara, Brignole; Bensa, Veronica; Zotto, Genny Del; Bruno, Silvia; Fonseca, Nuno A; Cruz, Ana F; Paolo, Daniela Di; et al. "Nucleolin: A novel cell surface protein for neuroblastoma targeted therapy". Paper presented in AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, 2019.
    10.1158/1535-7163.targ-19-a101
  3. Fonseca, Nuno A.; Moura, Vera; Colelli, Fabiana; Pesce, Daniela; Signorino, Giacomo; Focareta, Laura; Fucci, Alessandra; et al. "In vivo targeting of mesothelioma’s molecular signature with nanoparticle functionalized with nucleolin-binding peptide". Paper presented in 110th Annual Meeting of the American Association for Cancer Research, Atlanta, 2019.
    Published • 10.1158/1538-7445.am2019-2994
  4. Cruz, Ana F.; Fonseca, Nuno A.; Gonçalves, Nélio; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Differential effect of liposomal C6-ceramide/doxorubicin targeted to nucleolin and conventional combinations against triple negative breast cancer stem cells". Paper presented in 10th Annual Meeting of the American Association for Cancer Research, Atlanta, 2019.
    Published • 10.1158/1538-7445.am2019-3622
  5. Marta Isabel Pereira; João T. Barata; Ana Bela Sarmento-Ribeiro; Moreira, João Nuno. "The prognostic impact of nucleolin overexpression in hematologic neoplasms.". Paper presented in Annual Meeting of the Portuguese Society of Hematology, Vilamoura, 2019.
    Published
  6. Fonseca, Nuno A.; Moura, Vera; Colelli, Fabiana; Pesce, Daniela; Cardile, Francesco; Pisano, Claudio; Simões, Sérgio; Moreira, João Nuno. "Targeting nucleolin with doxorubicin-containing nanoparticle induces a significant tumor growth inhibition in an orthotopic animal model of standard of care-resistant mesothelioma". Paper presented in AACR Annual Meeting 2017, Washington DC, 2017.
    Published • 10.1158/1538-7445.am2017-5155
  7. Cruz, Ana Filipa; Fonseca, Nuno A.; Sampaio, Susana F.; Moura, Vera; Almeida, Ramiro D.; Simões, Sérgio; Moreira, João Nuno. "Synergistic cytotoxicity of targeted liposomes containing doxorubicin and C6-ceramide against nucleolin-overexpressing ovarian cancer cells is supported by the downregulation of the Akt pathway". Paper presented in AACR Annual Meeting 2017, Washington DC, 2017.
    Published • 10.1158/1538-7445.am2017-2194
  8. Balça-Silva, Joana; do Carmo, Anália; Sarmento-Ribeiro, A. B.; Moura-Neto, Vivaldo; Lopes, Maria Celeste; Moreira, João Nuno. "Nucleolin overexpression in glioblastoma stem-like cells enables targeted intracellular delivery and improves cytotoxicity". Paper presented in : 41st FEBS Congress - Molecular and Systems Biology for a Better Life, Ephesus, 2016.
    10.1111/febs.2016.283.issue-S1 /react-text react-text: 53 /react-text react-text: 54 /react-text react-text: 55
  9. Valério-Fernandes, Ângela; Fonseca, Nuno A.; Moura, V.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; Simões, S.; Moreira, João Nuno. "Targeting Nucleolin in Lung Cancer: an emerging strategy to overcome stroma-mediated anti-VEGF resistance". Paper presented in 23rd Biennial Congress of the European Association for Cancer Research (EACR-23): From Basic Research to Personalised Cancer Treatment, Munich, 2014.
    Published
  10. Valério-Fernandes, Ângela; Fonseca, Nuno; Moura, Vera; Ladeirinha, Ana; Ferreira, Teresa; Alarcão, Ana; Carvalho, Lina; Simões, Sérgio; Moreira, João Nuno. "Targeting nucleolin: A potential strategy to overcome stroma-mediated bevacizumab resistance in lung cancer.". Paper presented in American Association for Cancer Research (AACR) Annual Meeting 2014: Harnessing Breakthroughs - Targeting Cures, San Diego CA, 2014.
    Published • 10.1158/1538-7445.am2014-3003
  11. Gregório, A.C.; Fonseca, N.A.; Moura, V.; Domingues, G.; Lacerda, M.; Figueiredo, P.; Simões, S.; Dias, S.; Moreira, João Nuno. "Targeting cell-surface nucleolin in metastatic breast cancer.". Paper presented in EACR23 23rd Biennial Congress of the European Association for Cancer Research, Munich, 2014.
    Published
  12. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria L.; Cruz, Maria M E; Soares, Raquel; Simões, Sérgio; Moreira, João. "A novel targeted triggered release nanoparticle against cancer cells of diverse histological origin.". Paper presented in AACR Annual Meeting 2013, Washington DC, 2013.
    Published • 10.1158/1538-7445.am2013-4521
  13. Moreira, João Nuno; N. Monteiro; A. Martins; R. Pires; S. Faria; Fonseca, Nuno A.; R. L. Reis; N. M. Neves. "Immobilization of bioactive factor-loaded liposomes at the surface of electrospun nanofibers targeting tissue engineering strategies". Porto, 2013.
    Published
  14. Monteiro N. S.; Martins A.; Ribeiro D.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "Induction of Human Mesenchymal Stem Cells Osteogenesis by Bioactive Agent-Releasing Liposomes". Paper presented in Term Stem, Guimarães, 2012.
    Published
  15. Carvalho, Lina; Alarcão, A; Ladeirinha, Ana; D'Aguiar, MJ; Ferreira, T; Moura, Vera; Lacerda, Manuela; et al. "Nuclear and cytoplasmic expression of nucleolin depends on accurate validity". Paper presented in 24th European Congress of Pathology., Prague, 2012.
    Published
  16. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, M. Luisa; Cruz, M. Eugenia M.; Soares, Raquel; de Lima, M. Conceicao Pedroso; Simoes, Sergio; Moreira, Joao Nuno. "Limiting tumor invasion with multifunctional nanoparticle targeting the tumor microenvironment.". Paper presented in AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, San Francisco, CA, 2011.
    10.1158/1535-7163.targ-11-c233
  17. Figueiredo, Sara; Moreira, João Nuno; Geraldes, CF; Aime, Silvio; Terreno, Enzo. "Gd-loaded yeast cell wall particles: an innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Torino, 2011.
  18. Gomes-da-Silva, L.C.; Ramalho, JS; Pedroso de Lima, M.C.; Simões, Sérgio; Moreira, João Nuno. "Targeted Gene Silencing for Cancer Treatment.". Paper presented in 16th International Charles Heidelberger Symposium on Cancer Research, Coimbra, 2010.
    Published
  19. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, M. Luisa; Cruz, ME; Maria C. Pedroso de Lima; Simões, Sérgio; Moreira, João Nuno. "Targeting non-viral vectors to tumor cells and the tumor micronvironment.". Paper presented in The 16th International Charles Heidelberger Symposium on Cancer Research, Coimbra, 2010.
    Published
  20. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria Luisa; Cruz, Maria Eugénia; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João Nuno. "Targeted delivery of therapeutics to tumor cells and the tumor microenvironment". Paper presented in AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics, Boston, 2009.
    Published • 10.1158/1535-7163.TARG-09-A129
  21. Carvalho, JFS; Cruz Silva, M.M.; Moreira, João Nuno; Simões, Sérgio; Sa´ e Melo, M. Luisa. "Cytotoxic epoxysterols: chemoenzymatic synthesis, biological evaluation and SAR.". Paper presented in Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, Barcelona, 2009.
    Published
  22. Santos, A.; Pereira, J. P.; Simões, S.; Moreira, João Nuno. "SiRNA mediated downregulation of Bcl-2 in small cell lung cancer cell lines - impact on protein level and cell viability". Paper presented in 20th Meeting of the European-Association-for-Cancer-Research, Lyon, 2008.
    Published
  23. Moura, V.; Simões, S.; Pedroso de Lima, M.C.; Moreira, João Nuno. "Novel approaches to breast cancer therapy – simultaneous targeting to tumor and endothelial cells". Paper presented in 20th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, Geneva, 2008.
    Published • 10.1016/S1359-6349(08)71990-6
  24. Pinto, A. C.; Moreira, João Nuno; Simões, S.. "In vitro evaluation of combined effects of conventional and new cytotoxic agents against a hormone-refractory prostate cancer (HRPC) cell line.". Paper presented in 7th World Basic Urological Research Congress - Joint Meeting of the European Society for Urological Research and the Society for Basic Urologic Research, Dublin, 2007.
    Published
  25. Fonseca, Nuno A.; Moreira, João Nuno; Mendonça, L.; Cabrita, A.; Paiva, A.; Lopes, M. T. C.; Pedroso De Lima, M.C.; et al. "Targeted delivery of antisense oligonucleotides to human T-leukemia cells mediated by novel liposomal formulations: evaluation of in vitro and in vivo anti-tumoral activity". Paper presented in 9th Annual Meeting of the American Society of Gene Therapy, Baltimore, 2006.
    Published • https://doi.org/10.1016/j.ymthe.2006.08.1059
  26. Moreira, João Nuno; Gaspar, Rogério; Allen, T. M.. "In vivo targeting of stealth liposomes against human small cell lung cancer.". Paper presented in 8th Liposome Research Days Conference., Berlin, 2003.
    Published
Conference poster
  1. Martins, Ângela; Ivasiv, Viktoriya; Bertão, Ana; Nunes, Nélson; Aguiar, C. Almeida; Fonseca, A. M.; Moreira, João Nuno; et al. "P12.010 Metal ion-hierarchical zeolites as Fenton-like catalysts for health applications". Paper presented in 20th International Zeolite Conference; Valencia, Spain, 2022.
  2. Santos, Liliana; Tomatis, Francesca; Ferreira, Hugo R. S.; Sereno, José Vitor Oliveira; Almeida, Sara F.F.; Ferreira, Lino; Silva, Ana Paula; et al. "Trastuzumab-resistant HER2+ Brain Tropic Breast Cancer Cells Disrupt the Blood-Brain Barrier: a Potential Route for Brain Drug Delivery". Paper presented in 5th ASPIC International Congress, 2022.
  3. Cláudia Pina Costa; Nizic Nodilo; L. Zadravc; D. Kalogiera; Moreira, João Nuno; José Manuel Sousa Lobo; A. Hafner; Ana Catarina Silva. "P20: Evaluation of the deposition of an in situ hydrogel containing diazepam loaded nanostructured lipid carriers (NLC) in a 3D nasal cavity model.". Paper presented in 13th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2022.
  4. Costa, CP; Cunha, S.; Moreira, João Nuno (EF1B-FA3D-0787); Sousa Loubo, JM; Silva, AC. "Optimization of diazepam-loaded nanostructured lipid carriers (NLC) for nose-to-brain delivery using the quality by design (QbD) approach, Abstract nr 46". Paper presented in Virtual Vancouver Nanomedicine Day, 2020.
  5. C.P. Costa; S. Cunha; Moreira, João Nuno; M.H. Amaral; J.M. Sousa Lobo; A.C. Silva. "Optimization of lipid nanoparticles formulation for nose-to-brain delivery using the quality by design (QbD) approach". Paper presented in 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, 2020.
  6. Ribeiro, R.; Moreira, João Nuno; Gonçalves, J.. "Increasing the affinity of anti-nucleolin antibodies against triple negative breast cancer using a phage display approach". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  7. Abreu, Teresa; Fonseca, Nuno A.; Moreira, João Nuno. "Specific recognition of the onco-target nucleolin by the tumor homing F3 peptide". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  8. Biscaia-Caleiras, M.; Fonseca, Nuno A.; Cruz, A.F.; Gonçalves, N.; Moreira, João Nuno. "Targeted delivery of doxorubicin and C6-ceramide combinations to non-small cell lung cancer cells - Key factors for C6-ceramide's cytotoxicity". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  9. Cruz, A. F.; Fonseca, Nuno A.; Gonçalves, N.; Moura, V.; Simões, S.; Moreira, João Nuno. "Synergistic cytotoxicity of targeted liposomal C6-ceramide and doxorubicin against nucleolin-overexpressing cancer cells is supported by the downregulation of the PI3K/Akt pathway". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  10. Costa, C. P.; Cunha, S.; Moreira, João Nuno; Amaral, N. H.; Sousa Lobo, J. M.. "Hydrogel formulations containing nanostructured lipid carriers (NLC) and nanoemulsions (NE) for intranasal delivery of carbamazepine". Paper presented in 1st Annual Meeting in Pharmaceutical Sciences, 2019.
  11. Cruz, A. F.; Fonseca, Nuno A.; Gonçalves, N.; Moura, V.; Simões, S.; Moreira, João Nuno. "The Potential Of Liposomal C6-ceramide/doxorubicin Targeted To Nucleolin To Decrease Triple-negative Breast Cancer Stem Cell Population, Relative To A Standard Of Treatment". Paper presented in 2019 Controlled Release Society Annual Meeting, 2019.
  12. Costa, C. P.; Cunha, S.; Silva, A.C.; Amaral, M. H.; Sousa Lobo, J. M.; Moreira, João Nuno. "Development Of A Semi-solid Formulation For The Intranasal Delivery Of Carbamazepine By Means Of Lipid-based Nanosystems". Paper presented in 2019 Controlled Release Society Annual Meeting, 2019.
  13. Fonseca, Nuno A.; Gregório, A.C.; Mendes, V.; Lopes, R.; Manadas, B.; Lacerda, M.; Figueiredo, P.; et al. "Tumor intracellular bioavailability of doxorubicin determines therapeutic efficacy of nanoparticle targeted to nucleolin". Paper presented in 3rd ASPIC International Congress, 2018.
  14. C. Pechincha; Fonseca, Nuno A.; J. S. Ramalho; Moreira, João Nuno. "Nucleolin as a functional driver of breast cancer cells and a target for anti-cancer therapies". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  15. Cruz, A. F.; Fonseca, Nuno A.; Moura, V.; Simões, S.; Moreira, João Nuno. "Cytotoxicity of targeted liposomal C6-ceramide and doxorubicin against nucleolin-overexpressing cancer cell lines is supported by the downregulation of the Akt pathway and is more effective than conventional drug combinations". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  16. Romano, N.; Oliveira, A. R.; Moura, V.; Simões, S.; Moreira, João Nuno. "Engineering novel anti-nucleolin antibody fragments with antibody-dependent cell-mediated cytotoxicity". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  17. Gonçalves, N.; Fonseca, Nuno A.; Moreira, João Nuno. "Cell surface/cytoplasmic relative levels of nucleolin: a key feature for successful anticancer nanotherapies targeting nucleolin". Paper presented in XII Spanish-Portuguese Conference on Controlled Drug Delivery, 2018.
  18. Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Valerie LeBleu; Raghu Kalluri; Moreira, João Nuno. "Epigenetic unbalance may increase lung incidence in patients affected by idiopatic pulomonary fibrosis". Paper presented in ERS Conference, 2017.
  19. Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Valerie LeBleu; Moreira, João Nuno. "The presence of activated fibroblasts can explain the increase incidence of lung cancer after pulmonary fibrosis". Paper presented in ASPIC Conference, 2016.
  20. Balça-Silva, Joana; Moreira, João Nuno; do Carmo, Anália; Moura Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela. "Specific cellular association of liposomes by stem-like cells improves therapeutic efficacy in glioblastoma". Paper presented in Annual Meeting of Neuroscience, 2016.
  21. Mariangela Natale; Sylvia Vong; Michael Zeisberg; Lina Carvalho; Björn Tampe; Moreira, João Nuno; Valerie LeBleu; Raghu Kalluri. "Functional role of alfa smooth muscle actin positive cells in the pathogenesis of lung cancer". Paper presented in University of Germany, 2015.
  22. Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Moreira, João Nuno; Valerie LeBleu; Raghu Kalluri. "Genome wide analysis of human lung cancer associated fibroblasts (CAFs): The functional contribution of alfa smooth muscle actin positive myofibroblasts in the initiation of lung cancer". Paper presented in MD Anderson Cancer Center, GAP Conference, 2015.
  23. Moreira, João Nuno; Gregório, A.C.; Fonseca, Nuno A.; Moura, V.; Domingues G.; Lacerda, M.; Figueiredo, P.; Simões, S.; Dias S.. "Targeting cell surface nucleolin in metastatic breast cancer". Paper presented in 1st ASPIC International Congress of the Portuguese Association for Cancer Research, 2014.
  24. Mariangela Natale; Sylvia Vong; Björn Tampe; Michael Zeisberg; Lina Carvalho; Moreira, João Nuno; Valerie LeBleu; Raghu Kalluri. "Cancer Associated Fibroblasts in the microenvironmet of lung cancer". Paper presented in Medimmune, 2014.
  25. Valério-Fernandes, Ângela; Fonseca, Nuno A.; Moura, Vera; Ladeirinha, Ana; Ferreira, Teresa; Alarcão, Ana; Carvalho, Lina; Simões, Sérgio; Moreira, João Nuno. "Nucleolin in lung cancer – an emerging target to overcome stroma-mediated anti-angiogenic resistance". Paper presented in 1st ASPIC International Congress, 2014.
  26. Fonseca, Nuno A.; Rodrigues, Ana S.; Rodrigues-Santos, Paulo; Alves, Vera; Santos-Rosa, Manuel; Moura, Vera; Ramalho-Santos, João; Simões, Sérgio; Moreira, João Nuno. "Nucleolin-mediated targeting of breast cancer cell subpopulations with different stem-like phenotype". Paper presented in 1st ASPIC International Congress, 2014.
  27. Valério-Fernandes, Â.; Fonseca, N.A.; Moura, V.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; et al. "Nucleolin-mediating targeting of the tumor microenvironment in bevacizumab-resistant Lung Cancer". Paper presented in Xth Spanish-Portuguese Conference on Controlled Drug Delivery: Drug Delivery Systems from Lab to Clinic – New Trends and Opportunities, 2013.
  28. Fonseca, Nuno A.; Simões, Sérgio; Moreira, João Nuno. "Rational design of synergistic drug combinations against breast cancer". Paper presented in EMBO Young Scientists’ Forum, 2013.
  29. Valério-Fernandes, Â.; Fonseca, Nuno A.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; Simões, S.; Moreira, João Nuno. "Assessing the potential of nucleolin-targeted strategies against Lung Cancer resistant to anti-VEGF therapies". Paper presented in XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting -TRANSLATIONAL RESEARCH IN CANCER, 2013.
  30. Monteiro N.; Martins A.; Pires R.; Faria S.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "Release of Bioactive Agent from Liposomes Immobilized on Electrospun Nanofibers Targeting Tissue Engineering Applications". Paper presented in Annual Meeting of the Society For Biomaterials, 2013.
  31. Monteiro N.; Martins A.; Ribeiro D.; Faria S.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "On the Use of Dexamethasone Loaded Liposomes to Induce the Osteogenic Differentiation of Human Mesenchymal Stem Cells". Paper presented in Annual Meeting of the Society For Biomaterials, 2013, 2013.
  32. Valério-Fernandes, Â.; Fonseca, Nuno A.; Ladeirinha, A.; Ferreira, T.; Alarcão, A.; Carvalho, L.; Moreira, João Nuno. "Targeted drug delivery to the tumor microenvronment in lung cancer". Paper presented in X Annual Meeting of the Center for Neuroscience and Cell Biology, 2012.
  33. Carvalho, J. F. S.; Jeremias, H.; Silva, M. M. C.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.. "Exploring the relevance of the oxysteril's C-6 and C-7 positions for cytotoxicity". Paper presented in 3rd Portuguese meeting on Medicinal Chemistry, 2012.
  34. Monteiro N. S.; Martins A.; Ribeiro D.; Pires R. A.; Fonseca, Nuno A.; Moreira, João Nuno; Reis R. L.; Neves N. M.. "Release of growth factors from liposomes immobilized on electrospun nanofibers targeting tissue engineering applications". Paper presented in 3rd MIT-Portugal Program Conference, 2012.
  35. Figueiredo, S.; Rizzitelli, S.; Aime, S.; Geraldes, C.F.G.C.; Moreira, João Nuno. "Nature-inspired particles as carriers for multimodal molecular imaging applications". Paper presented in IEEE 2nd Portuguese Meeting In Bioengineering, 2012.
  36. Carvalho, J.F.S.; Jeremias, H.; Silva, M. M. C.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.. "Oxysterol as selective cytotoxic and chemosensitizer agents. Synthesis and cell proliferation studies". Paper presented in . III Congress of the Portuguese Society of Pharmaceutical Sciences and IX Spanish Conference on Controlled Drug Delivery, 2011.
  37. Moura, V.; Figueiredo, P.; Corvo, M. L.; Cruz M. E.; Soares, R.; Pedroso de Lima, M.C.; Simões, S.; Moreira, João Nuno. "Targeted and triggered to the tumor microenviroment: impact on the treatment of solid tumors". Paper presented in Congress of the Portuguese Society of Pharmaceutical Sciences and IX Spanish Conference on Controlled Drug Delivery, 2011.
  38. Fonseca A. R.; Alves, R.; Gonçalves, A. C.; Silva, L.; Alves, A.; Moreira, João Nuno; Sarmento-Ribeiro, A. B.. "RNAi induced down-regulation of FLT3 expression in Acute Myeloid Leukemia (AML) and increase sensitivity to the Proteasome Inhibitor, MG262". Paper presented in THE Young European Scientist Meeting (YES Meeting), 2011.
  39. Figueiredo, S.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.; Terreno, E.. "Gd-loaded yeast cell wall particles as an innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Paper presented in Metal-Based Systems for Molecular Imaging Applications - Cost D38 Final Meeting, 2011.
  40. Figueiredo, S.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E.; Moreira, João Nuno. "Gd-loaded yeast cell wall particles as an innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Paper presented in World Molecular Imaging Congress, 2011.
  41. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.; Aime, S.. "Gd-loaded Yeast cell wall particles: an innovative micron-sized platform for labeling and tracking immune cells by multimodal imaging". Paper presented in 36th FEBS Congress, 2011.
  42. Pinto, A.C.; Moreira, João Nuno; Simões, S.. "Liposomal imatinib-mitoxantrone combination: formulation development and therapeutic evaluation in an animal model of prostate cancer". Paper presented in I Symposium on Nanoscience and Biomedical Nanotechnology, 2011.
  43. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.; Aime, S.. "Yeast cell wall particles as highly sensitive MRI contrast agents". Paper presented in Metal-Based Systems for Molecular Imaging Applications - Joint Working Groups 2 and 6 meeting, 2011.
  44. Carvalho, J. F. S.; Silva, M.M.C.; Moreira, João Nuno; Simões, S.; Riva, S; Sá e Melo, M. L.. "Synthesis of a library of glycosyl and acyl glycosyl oxysterols, cytotoxic profile and SAR". Paper presented in 2nd National Meeting on Medicinal Chemistry - Portuguese Chemical Society (SPQ), 2010.
  45. Carvalho, J. F. S.; Silva, M.M.C.; Moreira, João Nuno; Simoes, S.; Sá e Melo M. L.. "Synthesis and cytotoxic evaluation of trihydroxysteroids". Paper presented in XXI International Symposium on Medicinal Chemistry, 2010.
  46. Figueiredo, S.; Cittadino, E.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "Gd(III)-loaded liposomes as enzyme responsive MRI probes". Paper presented in 2010 World Molecular Imaging Congress, 2010.
  47. Moura, V.; Lacerda, M.; Figueiredo, P.; Corvo, M. L.; Cruz, M. E.; Pedroso De Lima, M.C.; Simões, S.; Moreira, João Nuno. "Targeting non-viral vectors to tumor cells and the tumor micronvironment". Paper presented in 16th International Charles Heidelberger Symposium on Cancer Research, 2010.
    10.1186/1753-6561-4-s2-o26
  48. Gomes da Silva, L. C.; Ramalho, J.S.; De Lima, M.C.P.; Simões, S.; Moreira, João Nuno. "Targeted Gene Silencing for Cancer Treatment". Paper presented in The 16th International Charles Heidelberger Symposium on Cancer Research, 2010.
    10.1186/1753-6561-4-S2-P45
  49. Figueiredo, S.; Geraldes, C. F. G. C.; Moreira, João Nuno; Aime, S.. "MRI intelligent contrast agents as Enzyme Responsive Nanosystems". Paper presented in 5th European Molecular Imaging Meeting, 2010.
  50. Gomes-da-Silva, L.C.; Bimbo, L.; Santos, A.; Ramalho, J. S.; de Lima, M.C.P.; Simões, S.; Moreira, João Nuno. "Ligand-mediated targeted nanocarriers containing siRNA for cancer treatment". Paper presented in Keystone Symposia on Molecular and Cell Biology: New Paradigms in Cancer Therapeutics, 2010.
  51. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "Paramagnetic liposomes as enzyme-responsive relaxometric agents". Paper presented in 8th Inorganic Chemistry Conference, 2009.
  52. Carvalho, J.F.S.; Silva, M.M.C.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.; Carvalho, J. F. S.; Cruz Silva, M.M.. "Cytotoxic epoxysterols: chemoenzymatic synthesis, biological evaluation and SAR". Paper presented in Frontiers in Medicinal Chemistry: Emerging Targets, Novel Candidates and Innovative Strategies, 2009.
  53. Figueiredo, S.; Cittadino, E.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.; Aime, S.. "SMART MRI contrast agents: enzyme responsive Nanosystems". Paper presented in 2009 World Molecular Imaging Congress, 2009.
  54. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C.F.G.C.. "Paramagnetic liposomes as enzyme-responsive relaxometric agents". Paper presented in 7th International Conference on f-Elements, 2009.
  55. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "Paramagnetic liposomes as enzyme-responsive relaxometric agents". Paper presented in The 6th Conference on Field Cycling NMR Relaxometry, 2009.
  56. Figueiredo, S.; Terreno, E.; Moreira, João Nuno; Geraldes, C. F. G. C.; Aime, S.. "MRI intelligent contrast agents: enzyme responsive nanosystems". Paper presented in Meditrans Second Annual Meeting, 2009.
  57. Firmino, F.; Mendonça, L.S.; Moreira, João Nuno; Pedroso De Lima, M.C.; Simões, S.. "Delivery of asODNs to chronic myeloid leukaemia by transferrin receptor targeted liposomes". Paper presented in 7th Congress of the Portuguese-Spanish Chapter of the Controlled Release Society, 2008.
  58. Carvalheiro, M.; Moreira, João Nuno; Simões, S.; Cruz, M.E.M.. "Targeted delivery of c-myc antisense oligodeoxynucleotide to SCLC mediated by novel lipidc vesicles". Paper presented in First Internal Meeting of iMed.UL, 2008.
  59. Pinto, A.C.; Ângelo, S.; Moreira, João Nuno; Simões, S.. "Individual or co-encapsulated liposomal Imatinib-mitoxantrone combination for hormone-refractory prostate cancer therapy". Paper presented in 7th Congress of the Portuguese-Spanish Chapter of the Controlled Release Society, 2008.
  60. Santos, A.; Pereira, J.P.; Sarmento-Ribeiro, A.B.; Simões, S.; Pedroso de Lima, M. C.; Moreira, João Nuno. "Targeted therapeutics in SCLC – BCL2 revisited". Paper presented in Annual Meeting of the Center for Neuroscience and Cell Biology, 2007.
  61. Colla, M.; Moreira, João Nuno; Simões, S.. "Targeted delivery of c-Myc antisense oligodeoxynucleotide mediated by novel lipidic vesicles". Paper presented in 1st European Science Foundation Summer School in Nanomedicine, 2007.
  62. Fonseca, C.; Mendonça, L.; Moreira, João Nuno; Cabrita, A.; Paiva, A.; Lopes, M. T.; Pedroso de Lima, M.C.; Simões, S.. "Novel nanobiotechnology-based approaches for gene silencing: in vitro and in vivo evaluation for the treatment of human acute lymphoblastic leukemia". Paper presented in Encontro da Associação Nacional de Farmácias, 2007.
  63. Pedroso de Lima, M. C.; Moura, V.; Simões, S.; Moreira, João Nuno. "Targeting stealth liposomes to human breast cancer cells with a vasculature-homing peptide". Paper presented in Annual Meeting of the Center for Neuroscience and Cell Biology, 2006.
  64. Santos, A.; Zangemeister-Wittke, U.; Pedroso De Lima, M.C.; Simões, S.; Moreira, João Nuno. "Targeted downregulation of the BCL2 oncogene: a promising therapeutic strategy against small cell lung cancer". Paper presented in 7th Congress of the Portuguese-Spanish Chapter of the Controlled Release Society, 2006.
  65. Carvalho, J. F. S.; Silva, M.M.C.; Marques, A.; Moreira, João Nuno; Simões, S.; Sá e Melo M. L.. "Oxysterols as potential anticancer agents. Synthesis and biological evaluation". Paper presented in Medicinal Chemistry in the 21st Century, 2006.
  66. Colla, M.; Moreira, João Nuno; Simões, S.; Cruz, M. E.. "Antagonist G targeted stabilized antisense-lipid particles (SALP-G): a novel vector for delivery of antisense oligonucleotides to small cell lung cancer". Paper presented in 7th Congress of the Portuguese-Spanish Chapter of the Controlled Release, 2006.
  67. Moreira, João Nuno; Pinto, A. C.; Simões, S.. "Ciprofloxacin and imatinib sensitize hormone-refractory prostate cancer cells to conventional cytotoxic agents in a schedule-dependent manner". Paper presented in ACR Special Conference in Cancer Research - Innovations in prostate cancer research, 2006.
  68. Santos, A.; Zangemeister-Wittke, U.; Pedroso De Lima, M.C.; Simões, S.; Moreira, João Nuno. "Antisense oligonucleotide-containing liposomes targeted to growth fator receptors in small cell lung cancer". Paper presented in International Liposome Society 2005 – Annual Meeting – Liposome Advances: Progress in Drug and Vaccine Delivery, 2005.
  69. Santos, A.; Zangemeister-Wittke, U.; Pedroso de Lima, M. C.; Simões, S.; Moreira, João Nuno. "Antagonist G peptide mediated uptake of liposomes containing bcl-2 antisense oligonucleotides in small cell lung cancer cells". Paper presented in Joint Annual Meeting of Graduate Programmes in Biosciences, 2005.
  70. Santos, A.; Simões, S.; Pedroso de Lima, M. C.; Moreira, João Nuno. "Novel targeted non-viral lipid-based vector for the treatment of human small cell lung cancer: intracellular delivery of antisense oligonucleotides". Paper presented in 2nd Congress of the Portuguese Society of Pharmaceutical Sciences and 6th Congress of the Portuguese-Spanish Chapter of the Controlled Release Society, 2005.
  71. Carvalho, J.F.S.; Cruz Silva, M. M. C.; Marques, A.; Moreira, João Nuno; Simões, S.; Sá e Melo M. L.. "Cytotoxic activity of a library of synthetic sterols". Paper presented in 2nd Congress of the Portuguese Society of Pharmaceutical Sciences and 6th Congress of the Portuguese-Spanish Chapter of the Controlled Release, 2005.
  72. Fonseca, C.; Moreira, João Nuno; de Lima, M.C.P.; Simões, S.. "Targeted delivery and pH-triggered release of antisense oligonucleotides mediated by novel liposome formulations". Paper presented in 2nd Congress of the Portuguese Society of Pharmaceutical Sciences and 6th Congress of the Portuguese-Spanish Chapter of the Controlled Release, 2005.
  73. Santos, A.; Simões, S.; Pedroso De Lima, M.C.; Moreira, João Nuno. "Targeted antisense therapy: a novel approach for the treatment of small cell lung cancer". Paper presented in Joint Annual Meeting of Graduate Programmes in Biosciences, 2004.
  74. Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.; Gonçalves, L.; Providência, L. A.. "Development of liposomes with affinity to ischemic myocardium". Paper presented in IV Congresso de Investigação em Medicina, 2004.
  75. Fonseca, C.; Moreira, João Nuno; Ciudad, C.; Pedroso de Lima, M. C.; Simões, S.. "Efficient intracellular delivery of antisense oligonucleotides to human T-leukemia cells mediated by targeted sterically stabilized pH-sensitive liposomes". Paper presented in 12th Annual Congress of the European Society of Gene Therapy, 2004.
  76. Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.; Gonçalves, L.; Providência, L. A.. "Development of liposomes with affinity to ischemic myocardium". Paper presented in 9th Annual Meeting of the American Society of Nuclear Cardiology, 2004.
  77. Carvalho, J. F. S.; Neves, M. A. C.; Filipe, A.; Moreira, João Nuno; Simões, S.; Sá e Melo M. L.. "Antitumor activity of a library of synthetic sterols". Paper presented in XVIIth International Symposium on Medicinal Chemistry, 2004.
  78. Cruz Silva, M.M.; Carvalho, J.F.S.; Neves, M. A. C.; Filipe, A.; Moreira, João Nuno; Simões, S.; Sá e Melo, M. L.. "Synthesis of polyhydroxysteroids and cytotoxic evaluation on HeLa cells". Paper presented in 19th National Meeting of the Portuguese Society of Chemistry, 2004.
  79. Fonseca, C.; Moreira, João Nuno; Ciudad, C.; Pedroso de Lima, M. C.; Simões, S.. "Novel formulations of targeted pH-sensitive liposomes bearing poly(ethylene glycol) as carriers for antisense oligonucleotides". Paper presented in 5th International Conference on Liposome Advances: Progress in Drug and Vaccine Delivery, 2003.
  80. Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.; Gonçalves, L.; Providência, L. A.. "Development of liposomes with affinity to ischemic myocardium – Preliminary results". Paper presented in Annual Congress of European Association of Nuclear Medicine, 2003.
  81. Antunes, A.; Botelho, M. F.; Gomes, C. M.; de Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Gonçalves, L.; Providência, L. A.. "Desenvolvimento de lipossomas com afinidade para as áreas miocárdicas isquémicas". Paper presented in IX Congresso Nacional de Medicina Nuclear, 2002.
  82. Fonseca, C.; Moreira, João Nuno; De Lima, M.C.P.; Simões, S.. "Novel formulations of targeted pH-sensitive liposomes bearing poly)(ethylene glycol". Paper presented in V Spanish-Portuguese Conference on Controlled Drug Delivery, 2002.
  83. Moreira, João Nuno; Gaspar, R.; Allen, T.M.. "In vivo targeting of Stealth liposomes against human small cell lung cancer". Paper presented in 8th Liposome Research Days Conference, 2002.
  84. Allen, T.M.; Sapra, P.; Moase, E.; Moreira, João Nuno; Iden, D.. "Adventures in targeting". Paper presented in 5th International Conference on Liposome Advances: Progress in Drug and Vaccine, 2001.
  85. Fonseca, C.; Moreira, João Nuno; Pedroso De Lima, M.C.; Simões, S.. "Development of novel formulations of targeted sterically stabilized pH-sensitive liposomes". Paper presented in 5th International Conference on Liposome Advances: Progress in Drug and Vaccine Delivery, 2001.
  86. Moreira, João Nuno; Gaspar, R.; Allen, T. M.. "Post-insertion of peptide ligands into pre-formed stealth® liposomes with retention of binding activity and cytotoxicity". Paper presented in 27th Meeting of the Federation of European Biochemical Societies, 2001.
  87. Moreira, João Nuno; Gaspar, R.; Allen, T. M.. "Imobilização à superfície de lipossomas de moléculas terapeuticamente activas: aumento da sua afinidade para receptores celulares específicos". Paper presented in Segundas Jornadas da Sociedade Portuguesa de Ciências Farmacêuticas, 2001.
  88. Moreira, João Nuno; Gaspar, R.; Allen, T. M.. "Lipossomas no transporte específico de doxorrubicina em terapia anti-tumoral". Paper presented in VII National Symposium of the Portuguese Association of Hospitalar Pharmacists, 2000.
  89. Moreira, João Nuno; Hansen, C.B.; Gaspar, R.; Allen, T.M.. "Pharmacokinetic properties and biodistribution of hexapeptide-targeted Stealth® liposomes". Paper presented in IV Spanish-Portuguese Conference Controlled Drug Delivery, 2000.
  90. Moreira, João Nuno; Kirchmeier, M.; Gaspar, R.; Allen, T.M.. "Intracellular trafficking of hexapeptide-targeted Stealth liposomal doxorubicin in a classical small cell lung cancer cell line". Paper presented in 7th Liposome Research Days Conference, 2000.
  91. Moreira, João Nuno; Hansen, C.B.; Gaspar, R.; Allen, T.M.. "In vitro targeting of poly(ethylene glycol)-grafted liposomes by hexapeptide to a classical small cell lung cancer cell line". Paper presented in 26th International Symposium on Controlled Release of Bioactive Materials, 1999.
  92. Botelho, M. F.; Pedroso de Lima, J. J.; Dormehl, I. C.; Moreira, João Nuno; Santos, A. C.; Gomes, C. M.; Baganha, M. F.. "Visualização de drenagem linfática através da inalação de lipossomas marcados". Paper presented in Congresso de Pneumologia, 1998.
  93. Botelho, M. F.; Moreira, João Nuno; Santos, A. C.; Gomes, C.; Gaspar, R.; Pedroso de Lima, J. J.. "Visualização linfática por simulação da biodistribuição de bacilos com radiolipossomas". Paper presented in III Congress of the Controlled Release Society, Spanish-Portuguese Local Chapter (SPLC-CRS), 1998.
  94. Gaspar, R.; Simões, S.; Moreira, João Nuno; Pereira de Almeida, L.; Alfar, S. C. F.; Gameiro, S.. "Drug targeting strategies with colloidal carriers: an integrated approach for therapeutic innovation". Paper presented in 1st Meeting on Opportunities for Pharmaceutical R&D in Portugal, 1998.
  95. Moreira, João Nuno; Hansen, C. B.; Allen, T.M.; Gaspar, R.. "Carboplatin encapsulation in sterically stabilized liposomes". Paper presented in 12th Annual Meeting of Groupe Tematique de Recherche sur les Vecteures, 1997.
  96. Moreira, João Nuno; Almeida, L.M.; Madeira, V.M.C.; Costa, M.L.. "In vitro characterization of O-palmitoylpullulan coated large unilamellar liposomes containing carboplatin". Paper presented in 1st Spanish-Portuguese Conference on Controlled Drug Delivery, 1995.
  97. Moreira, João Nuno; Almeida, L.M.; Geraldes, C.F.; Costa, M. L.. "Improvement of in vitro stability of liposomes by coating with a modified polysaccharide (O-palmitoylpullulan)". Paper presented in 12th European Conference on Biomaterials, 1995.
  98. Veiga, F.; Simões, S.; Moreira, João Nuno; Sousa, A.. "Evaluation of the in vitro dissolution of some commercial sustained release theophylline dosage forms". Paper presented in 11th Conference on Pharmaceutical Technology, 1992.
Edited book
  1. Moreira, João Nuno. Current Applications of Pharmaceutical Biotechnology. Springer International Publishing. 2020.
    Published • 10.1007/978-3-030-40464-2 • Editor
Journal article
  1. Ana Catarina Silva; João Nuno Moreira; José Manuel Sousa Lobo. "Current Insights on Lipid-Based Nanosystems 2023". Pharmaceuticals (2023): https://doi.org/10.3390/ph16121700.
    10.3390/ph16121700
  2. Ferreira, Débora; Santos-Pereira, Cátia; Costa, Marta; Afonso, Julieta; Yang, Sujuan; Hensel, Janine; McAndrews, Kathleen M.; et al. "Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple negative breast cancer cells". Biomaterials Advances 154 (2023): 213643. http://dx.doi.org/10.1016/j.bioadv.2023.213643.
    10.1016/j.bioadv.2023.213643
  3. A.C. Correia; J.N. Moreira; J.M. Sousa Lobo; A.C. Silva. "Design of experiment (DoE) as a quality by design (QbD) tool to optimize formulations of lipid nanoparticles for nose-to-brain drug delivery". Expert Opinion on Drug Delivery (2023): https://doi.org/10.1080/17425247.2023.2274902.
    10.1080/17425247.2023.2274902
  4. Pina Costa, Cláudia; Nižic Nodilo, Laura; Silva, Renata; Martins, Eva; Zadravec, Dijana; Kalogjera, Livije; Nuno Moreira, João; et al. "In situ hydrogel containing diazepam-loaded nanostructured lipid carriers (DZP-NLC) for nose-to-brain delivery: development, characterization and deposition studies in a 3D-printed human nasal cavity model". International Journal of Pharmaceutics 644 (2023): 123345. http://dx.doi.org/10.1016/j.ijpharm.2023.123345.
    Published • 10.1016/j.ijpharm.2023.123345
  5. Pinho, Jacinta O.; Matias, Mariana; Marques, Vanda; Eleutério, Carla; Fernandes, Célia; Gano, Lurdes; Amaral, Joana D.; et al. "Preclinical validation of a new hybrid molecule loaded in liposomes for melanoma management". Biomedicine & Pharmacotherapy 157 (2023): 114021. http://dx.doi.org/10.1016/j.biopha.2022.114021.
    Published • 10.1016/j.biopha.2022.114021
  6. Cangelosi, Davide; Brignole, Chiara; Bensa, Veronica; Tamma, Roberto; Malaguti, Fabiana; Carlini, Barbara; Giusto, Elena; et al. "Nucleolin expression has prognostic value in neuroblastoma patients". eBioMedicine 85 (2022): 104300. http://dx.doi.org/10.1016/j.ebiom.2022.104300.
    10.1016/j.ebiom.2022.104300
  7. Ana Catarina Silva; João Nuno Moreira; José Manuel Sousa Lobo. "Editorial—Current Insights on Lipid-Based Nanosystems". Pharmaceuticals (2022): https://doi.org/10.3390/ph15101267.
    10.3390/ph15101267
  8. Correia, A.C.; Monteiro, A.R.; Silva, R.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A.C.. "Lipid nanoparticles strategies to modify pharmacokinetics of central nervous system targeting drugs: Crossing or circumventing the blood–brain barrier (BBB) to manage neurological disorders". Advanced Drug Delivery Reviews 189 (2022): 114485. http://dx.doi.org/10.1016/j.addr.2022.114485.
    10.1016/j.addr.2022.114485
  9. Ribeiro, Rita; Carvalho, Maria João; Goncalves, João; Moreira, João Nuno. "Immunotherapy in triple-negative breast cancer: Insights into tumor immune landscape and therapeutic opportunities". Frontiers in Molecular Biosciences 9 (2022): http://dx.doi.org/10.3389/fmolb.2022.903065.
    Open access • Published • 10.3389/fmolb.2022.903065
  10. Cangelosi, Davide; Brignole, Chiara; Bensa, Veronica; Tamma, Roberto; Malaguti, Fabiana; Carlini, Barbara; Calarco, Enzo; et al. "Abstract 1276: Nucleolin has prognostic value in neuroblastoma patients". Cancer Research 82 12_Supplem (2022): 1276-1276. http://dx.doi.org/10.1158/1538-7445.am2022-1276.
    10.1158/1538-7445.am2022-1276
  11. Valério-Fernandes, Ângela; Fonseca, Nuno A.; Gonçalves, Nélio; Cruz, Ana F.; Pereira, Marta I.; Gregório, Ana C.; Moura, Vera; et al. "Nucleolin Overexpression Predicts Patient Prognosis While Providing a Framework for Targeted Therapeutic Intervention in Lung Cancer". Cancers 14 9 (2022): 2217. http://dx.doi.org/10.3390/cancers14092217.
    10.3390/cancers14092217
  12. Ferreira, Débora; Moreira, João Nuno; Rodrigues, Lígia R.. "New advances in exosome-based targeted drug delivery systems". Critical Reviews in Oncology/Hematology 172 (2022): 103628. http://dx.doi.org/10.1016/j.critrevonc.2022.103628.
    10.1016/j.critrevonc.2022.103628
  13. Cruz, Ana Filipa; Fonseca, Nuno A.; Malheiro, Ana Rita; B. Melo, Joana; Gaspar, Maria Manuela; Fernandes, Rui; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Targeted liposomal doxorubicin/ceramides combinations: The importance to assess the nature of drug interaction beyond bulk tumor cells". European Journal of Pharmaceutics and Biopharmaceutics 172 (2022): 61-77. http://dx.doi.org/10.1016/j.ejpb.2022.01.006.
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  18. Ana Filipa Fernandes da Cruz; Mariana Biscaia Caleiras; Nuno A. Fonseca; Nélio Gonçalves; Vera M. Mendes; Susana F. Sampaio; Vera Moura; et al. "The Enhanced Efficacy of Intracellular Delivery of Doxorubicin/C6-Ceramide Combination Mediated by the F3 Peptide/Nucleolin System Is Supported by the Downregulation of the PI3K/Akt Pathway". Cancers (2021): https://www.mdpi.com/2072-6694/13/12/3052.
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  24. Cunha, S.; Costa, C.P.; Moreira, João Nuno; Sousa Lobo, J.M.; Silva, A. C.. "Using the quality by design (QbD) approach to optimize formulations of lipid nanoparticles and nanoemulsions: A review". Nanomedicine: Nanotechnology, Biology and Medicine (2020): 102206. http://dx.doi.org/10.1016/j.nano.2020.102206.
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  27. Costa, C.; Moreira, J.N.; Amaral, M.H.; Sousa Lobo, J.M.; Silva, A.C.. "Nose-to-brain delivery of lipid-based nanosystems for epileptic seizures and anxiety crisis". Journal of Controlled Release 295 (2019): 187-200. http://dx.doi.org/10.1016/j.jconrel.2018.12.049.
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  28. Balça-Silva, Joana; do Carmo, Anália; Tão, Hermínio; Rebelo, Olinda; Barbosa, Marcos; Moura-Neto, Vivaldo; Sarmento-Ribeiro, Ana Bela; Lopes, Maria Celeste; Moreira, João Nuno. "Nucleolin is expressed in patient-derived samples and glioblastoma cells, enabling improved intracellular drug delivery and cytotoxicity". Experimental Cell Research 370 1 (2018): 68-77. http://dx.doi.org/10.1016/j.yexcr.2018.06.005.
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  29. Romano, Sofia; Moura, Vera; Simões, Sérgio; Moreira, João Nuno; Gonçalves, João. "Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies". Scientific Reports 8 1 (2018): http://dx.doi.org/10.1038/s41598-018-25816-8.
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  32. Cruz, Ana Filipa; Fonseca, Nuno Andre; Moura, Vera; Simoes, Sergio; Moreira, Joao Nuno. "Targeting Cancer Stem Cells and Non-Stem Cancer Cells: The Potential of Lipid- Based Nanoparticles". Current Pharmaceutical Design 23 43 (2018): 6563-6572. http://dx.doi.org/10.2174/1381612823666171115105252.
    10.2174/1381612823666171115105252
  33. Gregório, Ana C.; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno; Ana C. Gregório; et al. "Therapeutic Implications of the Molecular and Immune Landscape of Triple-Negative Breast Cancer". Pathology & Oncology Research 24 4 (2017): 701-716. http://dx.doi.org/10.1007/s12253-017-0307-2.
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  35. Fonseca, Nuno A.; Cruz, Ana Filipa; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "The cancer stem cell phenotype as a determinant factor of the heterotypic nature of breast tumors". Critical Reviews in Oncology/Hematology 113 (2017): 111-121. http://dx.doi.org/10.1016/j.critrevonc.2017.03.016.
    10.1016/j.critrevonc.2017.03.016
  36. Gregório, Ana C.; Fonseca, Nuno A.; Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Simões, Sérgio; Dias, Sérgio; Moreira, João Nuno. "Inoculated Cell Density as a Determinant Factor of the Growth Dynamics and Metastatic Efficiency of a Breast Cancer Murine Model". PLOS ONE 11 11 (2016): e0165817. http://dx.doi.org/10.1371/journal.pone.0165817.
    10.1371/journal.pone.0165817
  37. Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al. "Intravenous administration of brain-targeted stable nucleic acid lipid particles alleviates Machado-Joseph disease neurological phenotype". Biomaterials 82 (2016): 124-137. http://dx.doi.org/10.1016/j.biomaterials.2015.12.021.
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  38. Conceição, Mariana; Mendonça, Liliana; Nóbrega, Clévio; Gomes, Célia; Costa, Pedro; Hirai, Hirokazu; Moreira, João Nuno; et al. "Safety profile of the intravenous administration of brain-targeted stable nucleic acid lipid particles". Data in Brief 6 (2016): 700-705. http://dx.doi.org/10.1016/j.dib.2016.01.017.
    10.1016/j.dib.2016.01.017
  39. Nelson Monteiro; Albino Martins; Ricardo A. Pires; Susana Faria; Nuno A. Fonseca; João N. Moreira; Rui L. Reis; et al. "Dual release of a hydrophilic and a hydrophobic osteogenic factor from a single liposome". RSC Advances 6 115 (2016): 114599-114612. https://doi.org/10.1039/C6RA21623D.
    10.1039/C6RA21623D
  40. J. Goncalves; L. Graça; Moreira, João Nuno; I. V. Figueiredo; F. Scappaticci; J. Eurico Fonseca; F. Magro; et al. "Development of e-learning platform about biologic drugs with focus on monoclonal antibodies". International Journal of Clinical Pharmacy 38 2 (2016): 519-520.
    Published
  41. Fonseca, Nuno A.; Rodrigues, Ana S.; Rodrigues-Santos, Paulo; Alves, Vera; Gregório, Ana C.; Simões, Sérgio; Moreira, João Nuno. "Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination". Biomaterials 69 (2015): 76-88. http://dx.doi.org/10.1016/j.biomaterials.2015.08.007.
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  42. Zupancic, Eva; Peres, Carina; I Matos, Ana; Lopes, Joao; N Moreira, Joao; S Gaspar, Rogerio; F Florindo, Helena. "Translational Peptide-associated Nanosystems: Promising Role as Cancer Vaccines". Current Topics in Medicinal Chemistry 16 3 (2015): 291-313. http://dx.doi.org/10.2174/1568026615666150701115508.
    10.2174/1568026615666150701115508
  43. Monteiro, Nelson; Martins, Margarida; Martins, Albino; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.. "Antibacterial activity of chitosan nanofiber meshes with liposomes immobilized releasing gentamicin". Acta Biomaterialia 18 (2015): 196-205. http://dx.doi.org/10.1016/j.actbio.2015.02.018.
    10.1016/j.actbio.2015.02.018
  44. Fonseca, Nuno A.; Gomes-da-Silva, Lígia C.; Moura, Vera; Simões, Sérgio; Moreira, João Nuno. "Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination". Journal of Controlled Release 196 (2014): 122-131. http://dx.doi.org/10.1016/j.jconrel.2014.09.024.
    10.1016/j.jconrel.2014.09.024
  45. Monteiro, Nelson; Ribeiro, Diana; Martins, Albino; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.. "Instructive Nanofibrous Scaffold Comprising Runt-Related Transcription Factor 2 Gene Delivery for Bone Tissue Engineering". ACS Nano 8 8 (2014): 8082-8094. http://dx.doi.org/10.1021/nn5021049.
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  46. Fonseca, Nuno A.; Gregório, Ana C.; Valério-Fernandes, Ângela; Simões, Sérgio; Moreira, João N.. "Bridging cancer biology and the patients' needs with nanotechnology-based approaches". Cancer Treatment Reviews 40 5 (2014): 626-635. http://dx.doi.org/10.1016/j.ctrv.2014.02.002.
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  47. Zupancic, Eva; Silva, JoanaM; Videira, Mafalda A.; Moreira, João N.; Florindo, Helena F.. "Development of a Novel Nanoparticle-based Therapeutic Vaccine for Breast Cancer Immunotherapy". Procedia in Vaccinology 8 (2014): 62-67. http://dx.doi.org/10.1016/j.provac.2014.07.011.
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  48. Monteiro, Nelson; Martins, Albino; Pires, Ricardo; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.. "Immobilization of bioactive factor-loaded liposomes on the surface of electrospun nanofibers targeting tissue engineering". Biomater. Sci. 2 9 (2014): 1195-1209. http://dx.doi.org/10.1039/c4bm00069b.
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  49. Gomes-da-Silva, Lígia Catarina; Simões, Sérgio; Moreira, João Nuno; Gomes-da-Silva, L.C.; Simões, S.; Moreira, J.N.. "Challenging the future of siRNA therapeutics against cancer: the crucial role of nanotechnology". Cellular and Molecular Life Sciences 71 8 (2013): 1417-1438. http://dx.doi.org/10.1007/s00018-013-1502-2.
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  50. Gomes-da-Silva, Lígia C.; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N.. "Impact of anti-PLK1 siRNA-containing F3-targeted liposomes on the viability of both cancer and endothelial cells". European Journal of Pharmaceutics and Biopharmaceutics 85 3 (2013): 356-364. http://dx.doi.org/10.1016/j.ejpb.2013.04.007.
    Published • 10.1016/j.ejpb.2013.04.007
  51. Monteiro, Nelson; Martins, Albino; Ribeiro, Diana; Faria, Susana; Fonseca, Nuno A.; Moreira, João N.; Reis, Rui L.; Neves, Nuno M.; Moreira, João Nuno. "On the use of dexamethasone-loaded liposomes to induce the osteogenic differentiation of human mesenchymal stem cells". Journal of Tissue Engineering and Regenerative Medicine 9 9 (2013): 1056-1066. http://dx.doi.org/10.1002/term.1817.
    Published • 10.1002/term.1817
  52. Gomes-da-Silva, Lígia C; Fernández, Yolanda; Abasolo, Ibane; Schwartz, Simo; Ramalho, José S; Pedroso de Lima, Maria C; Simões, Sérgio; Moreira, João N. "Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform". Nanomedicine 8 9 (2013): 1397-1413. http://dx.doi.org/10.2217/nnm.12.174.
    Published • 10.2217/nnm.12.174
  53. Costa, Pedro M; Cardoso, Ana L; Mendonça, Liliana S; Serani, Angelo; Custódia, Carlos; Conceição, Mariana; Moreira, João N; Pereira de Almeida, Luís; Pedroso de Lima, Maria C. "Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells: a promising system for glioblastoma treatment". Molecular Therapy - Nucleic Acids 2 (2013): e100. http://dx.doi.org/10.1038/mtna.2013.30.
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  54. Gomes, C.P.; Gomes-da-Silva, L.C.; Ramalho, J.S.; de Lima, M.C.P.; Simões, S.; Moreira, J.N.. "Impact of PLK-1 silencing on endothelial cells and cancer cells of diverse histological origin". Current Gene Therapy 13 3 (2013): 189-201. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878633310&partnerID=MN8TOARS.
    10.2174/1566523211313030004
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  56. Gomes-da-Silva, Lígia C.; Santos, Adriana O.; Bimbo, Luís M.; Moura, Vera; Ramalho, José S.; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N.. "Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment". International Journal of Pharmaceutics 434 1-2 (2012): 9-19. http://dx.doi.org/10.1016/j.ijpharm.2012.05.018.
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  57. Gomes-da-Silva, Lígia C.; Fonseca, Nuno A.; Moura, Vera; Pedroso de Lima, Maria C.; Simões, Sérgio; Moreira, João N.. "Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges". Accounts of Chemical Research 45 7 (2012): 1163-1171. http://dx.doi.org/10.1021/ar300048p.
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  58. Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio. "Development, Characterization and In Vitro Evaluation of Single or Co-Loaded Imatinib Mesylate Liposomal Formulations". Journal of Nanoscience and Nanotechnology 12 3 (2012): 2891-2900. http://dx.doi.org/10.1166/jnn.2012.5703.
    10.1166/jnn.2012.5703
  59. Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa. "Selective Cytotoxicity of Oxysterols through Structural Modulation on Rings A and B. Synthesis, in Vitro Evaluation, and SAR". Journal of Medicinal Chemistry 54 18 (2011): 6375-6393. http://dx.doi.org/10.1021/jm200803d.
    10.1021/jm200803d
  60. Botelho, M.F.; De Lima, J.J.P.; Dormehl, I.C.; Fontes Baganha, M.; Gomes, C.M.; Santos, A.C.; Moreira, J.N.; Kilian, E.. "[Visualization of deep lung lymphatic network using radioliposomes]. [Article in Portuguese]". Revista Portuguesa de Pneumologia (English Edition) 17 5 (2011): 240. http://dx.doi.org/10.1016/j.rppnen.2011.09.002.
    10.1016/j.rppnen.2011.09.002
  61. Moura, Vera; Lacerda, Manuela; Figueiredo, Paulo; Corvo, Maria L.; Cruz, Maria E. M.; Soares, Raquel; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N.. "Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer". Breast Cancer Research and Treatment 133 1 (2011): 61-73. http://dx.doi.org/10.1007/s10549-011-1688-7.
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  62. Figueiredo, Sara; Moreira, João Nuno; Geraldes, Carlos F. G. C.; Rizzitelli, Silvia; Aime, Silvio; Terreno, Enzo. "Yeast cell wall particles: a promising class of nature-inspired microcarriers for multimodal imaging". Chemical Communications 47 38 (2011): 10635. http://dx.doi.org/10.1039/c1cc14019a.
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  63. Figueiredo, S.; Moreira, J.N.; Geraldes, C.F.G.C.; Aime, S.; Terreno, E.. "Supramolecular protamine/Gd-loaded liposomes adducts as relaxometric protease responsive probes". Bioorganic and Medicinal Chemistry 19 3 (2011): 1131-1135. http://www.scopus.com/inward/record.url?eid=2-s2.0-79551487375&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.07.057
  64. Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio. "Liposomal imatinib-mitoxantrone combination: Formulation development and therapeutic evaluation in an animal model of prostate cancer". The Prostate 71 1 (2010): 81-90. http://dx.doi.org/10.1002/pros.21224.
    10.1002/pros.21224
  65. Carvalho, Joa~o F. S.; Silva, M. Manuel Cruz; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa. "Sterols as Anticancer Agents: Synthesis of Ring-B Oxygenated Steroids, Cytotoxic Profile, and Comprehensive SAR Analysis". Journal of Medicinal Chemistry 53 21 (2010): 7632-7638. http://dx.doi.org/10.1021/jm1007769.
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  66. Santos, A.O.; Pereira, J.P.; Pedroso de Lima, M.C.; Simões, S.; Moreira, J.N.. "In vitro modulation of Bcl-2 levels in small cell lung cancer cells: effects on cell viability". Brazilian Journal of Medical and Biological Research 43 10 (2010): 1001-1009. http://dx.doi.org/10.1590/s0100-879x2010007500099.
    Published • 10.1590/s0100-879x2010007500099
  67. Mendonça, Liliana S.; Moreira, João N.; de Lima, Maria C. Pedroso; Simões, Sérgio. "Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment". Biotechnology and Bioengineering 107 5 (2010): 884-893. http://dx.doi.org/10.1002/bit.22858.
    Published • 10.1002/bit.22858
  68. Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio. "Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy". Cancer Chemotherapy and Pharmacology 67 2 (2010): 275-284. http://dx.doi.org/10.1007/s00280-010-1315-z.
    Published • 10.1007/s00280-010-1315-z
  69. Santos, Adriana O.; da Silva, Lígia C. Gomes; Bimbo, Luís M.; de Lima, Maria C. Pedroso; Simões, Sérgio; Moreira, João N.. "Design of peptide-targeted liposomes containing nucleic acids". Biochimica et Biophysica Acta (BBA) - Biomembranes 1798 3 (2010): 433-441. http://dx.doi.org/10.1016/j.bbamem.2009.12.001.
    Published • 10.1016/j.bbamem.2009.12.001
  70. Mendonc¸a, Liliana S.; Firmino, Filipe; Moreira, João N.; Pedroso de Lima, Maria C.; Simões, Se´rgio. "Transferrin Receptor-Targeted Liposomes Encapsulating anti-BCR-ABLsiRNA or asODN for Chronic Myeloid Leukemia Treatment". Bioconjugate Chemistry 21 1 (2010): 157-168. http://dx.doi.org/10.1021/bc9004365.
    Published • 10.1021/bc9004365
  71. Santos, R.C.; Salvador, J.A.R.; Marín, S.; Cascante, M.; Moreira, J.N.; Dinis, T.C.P.. "Synthesis and structure-activity relationship study of novel cytotoxic carbamate and N-acylheterocyclic bearing derivatives of betulin and betulinic acid". Bioorganic and Medicinal Chemistry 18 12 (2010): 4385-4396. http://www.scopus.com/inward/record.url?eid=2-s2.0-77953321890&partnerID=MN8TOARS.
    10.1016/j.bmc.2010.04.085
  72. Carvalho, Joa~o F. S.; Cruz Silva, M. Manuel; Moreira, Joa~o N.; Simo~es, Se´rgio; Sa´ e Melo, M. Luisa. "Efficient Chemoenzymatic Synthesis, Cytotoxic Evaluation, and SAR of Epoxysterols". Journal of Medicinal Chemistry 52 13 (2009): 4007-4019. http://dx.doi.org/10.1021/jm9003973.
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  73. Cardoso, Ana; Trabulo, Sara; Moreira, João Nuno; Düzgünes, Nejat; de Lima, Maria C. Pedroso. "Targeted Lipoplexes for siRNA Delivery". Methods in Enzymology (2009): 267-287. http://dx.doi.org/10.1016/s0076-6879(09)65014-x.
    10.1016/s0076-6879(09)65014-x
  74. Pinto, Ana Catarina; Moreira, João Nuno; Simões, Sérgio. "Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner". Cancer Chemotherapy and Pharmacology 64 3 (2008): 445-454. http://dx.doi.org/10.1007/s00280-008-0892-6.
    Published • 10.1007/s00280-008-0892-6
  75. Santos, A.; Sarmento-Ribeiro, A. B.; de Lima, M. C. Pedroso; Simões, S.; Moreira, J. N.. "Simultaneous evaluation of viability and Bcl-2 in small-cell lung cancer". Cytometry Part A 73A 12 (2008): 1165-1172. http://dx.doi.org/10.1002/cyto.a.20634.
    Published • 10.1002/cyto.a.20634
  76. João Nuno Moreira; A. Santos; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões; Moreira, J.N.; Santos, A.; et al. "Non-viral lipid-based nanoparticles for cancer systemic gene silencing". Journal of Nanoscience and Nanotechnology 8 5 (2008): 2187-2204. http://www.scopus.com/inward/record.url?eid=2-s2.0-47149083118&partnerID=MN8TOARS.
    Published • 10.1166/jnn.2008.319
  77. Moreira, João Nuno; Santos, Adriana; Simões, Sérgio. "Bcl-2-Targeted Antisense Therapy (Oblimersen Sodium): Towards Clinical Reality". Reviews on Recent Clinical Trials 1 3 (2006): 217-235. http://dx.doi.org/10.2174/157488706778250050.
    Published • 10.2174/157488706778250050
  78. FONSECA, C; MOREIRA, J; CIUDAD, C; PEDROSODELIMA, M; SIMOES, S. "Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells". European Journal of Pharmaceutics and Biopharmaceutics 59 2 (2005): 359-366. http://dx.doi.org/10.1016/j.ejpb.2004.08.012.
    Published • 10.1016/j.ejpb.2004.08.012
  79. Simões, S; João Nuno Moreira; Nejat Düzgünes N; Maria C. Pedroso de Lima. "On the formulation of pH-sensitive liposomes with long circulation times". Advanced Drug Delivery Reviews 56 7 (2004): 947-965. http://dx.doi.org/10.1016/j.addr.2003.10.038.
    10.1016/j.addr.2003.10.038
  80. Moreira, J.N.; Gaspar, R.. "Antagonist G-mediated targeting and cytotoxicity of liposomal doxorubicin in NCI-H82 variant small cell lung cancer". Brazilian Journal of Medical and Biological Research 37 8 (2004): 1185-1192. http://www.scopus.com/inward/record.url?eid=2-s2.0-4444282289&partnerID=MN8TOARS.
    Published • 10.1590/s0100-879x2004000800008
  81. Moreira, J.N.; Simões, S.. "Technology evaluation: LErafAON, NeoPharm". Current Opinion in Molecular Therapeutics 5 5 (2003): 547-552. http://www.scopus.com/inward/record.url?eid=2-s2.0-0142154204&partnerID=MN8TOARS.
    Published
  82. Moreira, J.N.; Ishida, T.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Ishida, Tatsuhiro; Gaspar, Rogério; Allen, Theresa M.. "Use of the post-insertion technique to insert peptide ligands into pre-formed stealth liposomes with retention of binding activity and cytotoxicity". Pharmaceutical Research 19 3 (2002): 265-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036200912&partnerID=MN8TOARS.
    Published • 10.1023/A:1014434732752
  83. Allen, T.M.; Sapra, P.; Moase, E.; Moreira, João Nuno; Iden, D.. "Adventures in targeting". Journal of Liposome Research 12 1-2 (2002): 5-12. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036331129&partnerID=MN8TOARS.
    10.1081/LPR-120004771
  84. Moreira, João N.; Gaspar, Rogério; Allen, Theresa M.; Moreira, J.N.; Gaspar, R.; Allen, T.M.. "Targeting Stealth liposomes in a murine model of human small cell lung cancer". Biochimica et Biophysica Acta (BBA) - Biomembranes 1515 2 (2001): 167-176. http://dx.doi.org/10.1016/s0005-2736(01)00411-4.
    Published • 10.1016/s0005-2736(01)00411-4
  85. Moreira, J.N.; Hansen, C.B.; Gaspar, R.; Allen, T.M.; Moreira, João N.; Hansen, Christian B.; Gaspar, Rogério; Allen, Theresa M.. "A growth factor antagonist as a targeting agent for sterically stabilized liposomes in human small cell lung cancer". Biochimica et Biophysica Acta - Biomembranes 1514 2 (2001): 303-317. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035479680&partnerID=MN8TOARS.
    Published • 10.1016/S0005-2736(01)00386-8
  86. Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Madeira, V.M.C.; Costa, M.L.. "Carboplatin liposomes coated with O-palmitoylpullulan: In vitro characterization". International Journal of Pharmaceutics 147 2 (1997): 153-164. http://dx.doi.org/10.1016/s0378-5173(96)04808-9.
    Published • 10.1016/s0378-5173(96)04808-9
  87. Moreira, J.N.; Almeida, L.M.; Geraldes, C.F.; Costa, M.L.; Moreira, J. N.; Almeida, L. M.; Geraldes, C. F.; Costa, M. L.. "Evaluation of in vitro stability of large unilamellar liposomes coated with a modified polysaccharide (O-palmitoylpullulan)". Journal of Materials Science: Materials in Medicine 7 5 (1996): 301-303. http://www.scopus.com/inward/record.url?eid=2-s2.0-0030151980&partnerID=MN8TOARS.
    Published • 10.1007/bf00058571
  88. Veiga, F.; Simoes, S.; Moreira, J.N.; Sousa, A.. "Characterization of the in vitro dissolution of some commercial sustained release theophylline dosage forms". Drug Development and Industrial Pharmacy 20 8 (1994): 1471-1483. http://www.scopus.com/inward/record.url?eid=2-s2.0-0028335187&partnerID=MN8TOARS.
Magazine article
  1. Mariana Biscaia Caleiras; Simões, Sérgio (0A12-4D47-DC3C); Moreira, João Nuno. "Lipid Nanoparticles as a tool to tackle de patients needs: from small drugs to mRNA.", News Farma, 2021
  2. Moreira, João Nuno. "A Nanotecnologia e o desenvolvimento de novos medicamentos", Mundo Farmacêutico, 2011
  3. Ferreira, F.; Moreira, João Nuno; Prazeres, D. M.; Rocha, I.; Rodrigues, L.. "Bioteams: do Laboratório para o Mercado", Boletim Biotecnologia - Sociedade Portuguesa de Biotecnologia, 2011
  4. Antunes, A.; Botelho, M. F.; Gomes, C. M.; Lima, J. J. P.; Silva, M. L.; Moreira, João Nuno; Simões, S.. "Desenvolvimento de lipossomas com afinidade para áreas miocárdicas isquémicas", Ser Saúde, 2007
  5. Moreira, João Nuno. "Os lipossomas na terapia antitumoral: de esferas fosfolipídicas à aplicação clínica", Mundo Médico, 2000
Preface / Postscript
  1. Ana Catarina Silva; Moreira, João Nuno; Sousa Lobo, José Manuel; Hugo Almeida. "Preface: Current Applications of Pharmaceutical Biotechnology". Preface to Current Applications of Pharmaceutical Biotechnology, edited by Ana Catarina Silva; Moreira, João Nuno; Sousa Lobo, José Manuel; Almeida, Hugo. Springer International Publishing. 2020.
    Published
Thesis / Dissertation
  1. Moreira, João Nuno. "Targeting of liposomes to human small cell lung cancer". PhD, Universidade de Coimbra Faculdade de Farmácia, 2001.
  2. Moreira, João Nuno. "Characterization of carboplatin-containing liposomes coated with O-palmitoylpullulan". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 1994.

Intellectual property

Patent
  1. Fonseca, Nuno A.; Moura, Vera; Gregório, A.C.; Simões, Sérgio; Moreira, João Nuno. 2019. "Nanodelivery tissue targeting at low systemic exposures and methods thereof (PCT/PT2019/050034)".
    Pending
  2. Moreira, João Nuno; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões. 2018. "Ph-sensitive liposome binding to nucleolin (Granted, EP2291199)".
    Granted/Issued
  3. Nuno A. Fonseca; Gomes-da-Silva, L.C.; Vera Moura; Sérgio Simões; Moreira, João Nuno. 2018. "Platform for targeted delivery to stem cells and tumor cells and methods thereof (Granted - EP2983720)".
    Granted/Issued
  4. Moreira, João Nuno; Vera Moura; Maria C. Pedroso de Lima; Sérgio Simões. 2014. "Targeted delivery to human diseases and disorders (Granted - US Patent 8,741,338)". United States.
    Granted/Issued
  5. Moreira, João Nuno. 2013. "Targeted delivery to human diseases and disorders (Granted - US Patent 8,529,944)".
  6. Moreira, João Nuno. 2012. "Targeted delivery to human diseases and disorders (Granted - US Patent 8,231,895)".
  7. Moreira, João Nuno; Silva, L.; Santos, A.O.; Bimbo, L.; Pedroso de Lima, M.C.; Simões, S.. 2011. "F3-peptide targeted lipid-based nanoparticles useful for the treatment of angiogenesis-dependent diseases (PCT/PT2011/000008)". Portugal.
    Pending
  8. Mendonça, L.; Moreira, João Nuno; Pedroso de Lima, M.C.; Simões, S.. 2011. "Triple targeting with a single therapeutic system (PCT/PT2011/000005)". Portugal.
    Pending
Provisional application for patent
  1. 2020. "Moreira JN, Simões S, Fonseca N, Moura V, Cruz A, “Overcoming drug resistance associated with cancer stem cells and methods thereof” Portuguese Provisional Patent Application 116 084 B.".
    Disclosed
  2. 2018. "Fonseca N, Moura V, Gregório AC, Lopes RM., Simões S, Moreira JN, “Nucleolin-mediated intracellular drug release inhibits tumor growth at low systemic exposure” Portuguese Provisional Patent Application No 115032.".
  3. 2017. "Moreira, JN; Romano, S; Moura, V; Simões, S; Gonçalves, J. “Anti-nucleolin antibody”, Portuguese Provisional Patent Application No. 110214".
    Disclosed

Other

Spin-off company
  1. 2010. TREAT U, Lda (Co-founder). Oncology. http://treatu.pt/.
Distinctions

Award

2013 Best Poster presentation of the Translational and Clinical Research panel (XXII Porto Cancer Meeting & III Porto-Bordeaux Joint Meeting)
2012 Best Poster presentation - "Poster E2: Targeted drug delivery to the tumor microenvronment in lung cancer"
X Annual Meeting of the Center for Neuroscience and Cell Biology and Doctoral Programme in Experimental Biology and Biomedicine, Portugal
2012 João Nuno Moreira's research group was recognized by its activity on breast cancer
2011 2010 Education Innovation Awards
2011 Best Poster presentation- "Liposomal imatinib-mitoxantrone combination: formulation development and therapeutic evaluation in an animal model of prostate cancer"
Universidade Lusófona de Humanidades e Tecnologias, Portugal
2011 Best Oral communication - "Design of anti-PLK1 siRNA-containing liposomes and targeted to cancer cells and the tumor microenvironment"
IX Spanish Conference on Controlled Drug Delivery, Portugal
2011 Best PhD thesis Award for the thesis "Vetorização de fármacos para os vasos sanguíneos tumorais - uma nova terapia para o cancro da mama humano" written by Vera Moura, with supervision of JN Moreira
Controlled Release Society, United States
2010 Second place in the "Idea to Product I2P 2010" contest (5000 euros award)
COTEC Portugal , Portugal
2009 Best business idea with the technology "SMART MEDICINES”
ARRISCA COIMBRA 2009, Portugal
2008 Best Oral communication - "Smart nanomedicines for cancer"
MedTech Europe, Belgium
2007 Best Poster presentation - “Novel nanobiotechnology-based approaches for gene silencing: in vitro and in vivo evaluation for the treatment of human acute lymphoblastic leukemia"”.
Ordem dos Farmaceuticos, Portugal
2002 Best Oral communication - "Novel formulations of targeted pH-sensitive liposomes bearing poly(ethylene glycol)"
Controlled Release Society, United States

Other distinction

2004 Bial Award 2004 (Honourable Mention) fo the work entitled "Desenvolvimento de lipossomas com afinidade para áreas miocárdicas isquémicas"
Fundação Bial, Portugal