João Moura Alves (EF1E-2954-7885)

Curriculum Vitae

João Moura Alves

João Moura graduated in Biochemistry in the University of Porto in 2002 and completed a PhD degree in Biomedical Sciences in 2009, on the same University. He authored 24 publications in peer-review journals (14 as first author) and won 15 prizes/distinctions. During the third year of his bachelor¿s degree, João Moura started his scientific career as an undergraduate fellow in Pedro Moradas Ferreira¿s lab at the former IBMC (Porto, Portugal), studying the promoters of the three hydrogenases in Thiocapsa roseopersicina. He continued this study in the Biological Research Center (Szeged, Hungary), under the supervision of Kornel Kovacs, as part of his 6-month Erasmus scholarship. He later moved to Hematology, where he studied the migration patterns of neoplastic T-cells under the supervision of Margarida Lima in ICBAS (Porto, Portugal). During his PhD, he did extensive training in flow cytometry, cell sorting and cellular and molecular biology techniques. From the completion of his PhD in 2009 to the beginning of 2016, he moved away from science, embracing a part-time academic career in IPVC and a venture into the private sector. From 2014 to 2016, he laid ground for his return to science, collaborating in original work and reviewing important topics that led to 6 publications. In mid 2016 he resumed his full-time research activities in the CNC.IBILI (Coimbra, Portugal), under the supervision of Eugénia Carvalho and, as a result, in the last 5 years he authored 16 publications with an accumulated impact factor over 56 (Web of Science) and 266 citations with h=8 (Google scholar). In 2017, he earned a post-doc grant to continue this work. Simultaneously, he has sought independent financial support to continue his research, earning 10 scientific prizes and a total of 24.000¿ in small prizes and projects (as PI) that were used in the pursue of new diagnostic and therapeutic strategies in diabetic complications. He is a very skilled researcher with a broad and multidisciplinary background developed through his career, and with a strong experience in immunology and diabetic wound healing.

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Identification

Personal identification

Full name: João Moura Alves

Citation names

Moura, João

Author identifiers

Ciência ID: EF1E-2954-7885
ORCID iD: 0000-0002-7817-0881
Google Scholar ID: m1pE8LMAAAAJ&hl
Scopus Author Id: 57196873688

Email addresses

jmoura@cnc.uc.pt (Professional)
jmouraalves@gmail.com (Personal)

Addresses

Centro de Neurociências e Biologia Celular, Universidade de Coimbra, pólo I, Faculdade de Medicina, 1ºandar, 3004-504, Coimbra, Coimbra, Portugal (Professional)

Websites

http://www.cnbc.pt/about/people_show.asp?Id=33 (Professional)

Knowledge fields

Medical and Health Sciences - Basic Medicine - Immunology

Languages

Language	Speaking	Reading	Writing	Listening
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Advanced (C1)	Advanced (C1)	Intermediate (B1)	Advanced (C1)
Hungarian	Beginner (A1)	Beginner (A1)	Beginner (A1)	Beginner (A1)
Spanish; Castilian	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)

Education

	Degree	Classification
2009 Concluded	PhD in Biomedical Sciences (Doutoramento) Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal "Estudo comparativo dos mecanismos que regulam a migração e o tropismo tecidular dos linfócitos T normais e dos linfócitos T neoplásicos" (THESIS/DISSERTATION)	Unanimidade - unanimity
2002 Concluded	Bioquímica (Licenciatura) Universidade do Porto Faculdade de Ciências, Portugal "IDENTIFICAÇÃO E ESTUDO DOS PROMOTORES DOS OPERÕES (hup, hyd e hox) CODIFICANTES PARA AS 3 HIDROGENASES DE Thiocapsa roseopersicina BBS." (THESIS/DISSERTATION)	14

Affiliation

Science

	Category Host institution	Employer
2020/08/01 - Current	Postdoc (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2018/12/01 - 2020/07/31	Researcher (Research)	Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

2016/09/15 - 2018/11/30	Postdoc (Research)	Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

2003/01/01 - 2006/01/01	Research Trainee (Research)	Centro Hospitalar Universitário do Porto EPE, Portugal

2002/02/01 - 2002/08/01	Research Trainee (Research)	BRC, Hungary

2001/02/01 - 2002/02/01	Research Trainee (Research)	IBMC, Portugal

Teaching in Higher Education

	Category Host institution	Employer
2010/12/01 - 2016/09/14	Adjunct Teacher (Polytechnic Teacher)	Instituto Politécnico de Viana do Castelo, Portugal

2004/02/01 - 2010/11/30	Assistant (Polytechnic Teacher)	Instituto Politécnico de Viana do Castelo, Portugal

Projects

Grant

	Designation	Funders
2017 - 2020	HealthyAging 2020 CENTRO-01-0145-FEDER-000012-N2323 Post-doc Fellow CNC.IBILI, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2007/01 - 2009/06	Estudo comparativo dos mecanismos que regulam a migração e o tropismo tecidular dos linfócitos T normais e dos linfócitos T neoplásicos SFRH/BD/34471/2007 PhD Student Fellow	Ministério da Ciência Tecnologia e Ensino Superior Concluded

Contract

	Designation	Funders
2020/04/01 - 2021/03/31	Dissecting the role of relaxation in the reduction of inflammation and improved healing in diabetic foot ulcers Luís Marques – SPD 2020 grant Principal investigator Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal	Sociedade Portuguesa de Diabetologia Ongoing
2019 - 2021	CD20+ T Cells as a biomarker of inflammatory status and a promising target against cardiac rejection in heart transplanted patients Bolsa de Investigação SPT - Século XXI Principal investigator CNC.IBILI, Portugal	Sociedade Portuguesa de Transplantação Ongoing
2019 - 2020	MicroRNAs como biomarcadores e moduladores da cicatrização da úlcera diabética em pacientes sujeitos a terapia de relaxamento BOLSA LUÍS MARQUES -SPD Researcher CNC.IBILI, Portugal	Sociedade Portuguesa de Diabetologia Ongoing
2017 - 2019	Inhibition of macrophage protein tyrosine phosphatase 1B (PTP1B) as a novel therapy for improved wound healing in diabetes 17/0005621 Researcher University of Aberdeen, United Kingdom CNC.IBILI, Portugal	Diabetes UK Concluded
2016 - 2018	Combination therapy synergistically accelerates diabetic wound closure European Research Program in Microvascular Complications of Diabetes 2016 Researcher CNC.IBILI, Portugal	European Foundation for the Study of Diabetes Concluded
2016 - 2017	T-cells as a DFU biomarker Dr. M. M. Almeida Ruas 2016 Principal investigator CNC.IBILI, Portugal	Sociedade Portuguesa de Diabetologia Concluded

Outputs

Publications

Book chapter	Moura, João. "Saboreando a comida, molécula a molécula!". In Gastronomia, Religião e Cultura, edited by Centro de Estudos Regionais. Portugal: Centro de Estudos Regionais, 2021. Accepted
Journal article	Ermelindo C Leal; Tatiana Emanuelli; Diana Santos; João Moura; Ana Catarina RG Fonseca; Ana Burgeiro; Eugenia Carvalho. "Dysregulation of endoplasmic reticulum stress response in skin wounds in a streptozotocin-induced diabetes mouse model". Journal of Molecular Endocrinology (2023): https://doi.org/10.1530/JME-22-0122. 10.1530/JME-22-0122 Isadora Pombeiro; João Moura; Maria Graça Pereira; Eugénia Carvalho. "Stress-Reducing Psychological Interventions as Adjuvant Therapies for Diabetic Chronic Wounds". Current Diabetes Reviews (2021): https://doi.org/10.2174/1573399817666210806112813. 10.2174/1573399817666210806112813 Fernandes, Hélia; Moura, João; Carvalho, Eugénia. "mTOR Signaling as a Regulator of Hematopoietic Stem Cell Fate.". Stem cell reviews and reports (2021): https://doi.org/10.1007/s12015-021-10131-z. Published • 10.1007/s12015-021-10131-z Bombeiro, Isadora; Moura, João; Pereira, Maria da Graça; Carvalho, Eugénia. "Stress-reducing psychological interventions as adjuvant therapies for diabetic chronic wounds". Current Diabetes Reviews (2021): Accepted Seraphim, Patricia M.; Moura, João; Leal, Ermelindo C.; Gonçalves, Pedro; Gonçalves, Jenifer P.; Carvalho, Eugénia. "Lack of lymphocytes impairs macrophage polarization and angiogenesis in diabetic wound healing". Life Sciences 254 (2020): 117813. http://dx.doi.org/10.1016/j.lfs.2020.117813. Published • 10.1016/j.lfs.2020.117813 Moura, João. "Imbalance in T-cell differentiation as a biomarker of chronic diabetic foot ulceration.". Cellular & molecular immunology (2019): https://doi.org/10.1038/s41423-019-0233-1. Published • 10.1038/s41423-019-0233-1 Moura, João; Sørensen, Anja; Leal, Ermelindo C.; Svendsen, Rikke; Carvalho, Lina; Willemoes, Rie Juul; Jørgensen, Per Trolle; et al. "microRNA-155 inhibition restores Fibroblast Growth Factor 7 expression in diabetic skin and decreases wound inflammation". Scientific Reports 9 1 (2019): http://dx.doi.org/10.1038/s41598-019-42309-4. Published • 10.1038/s41598-019-42309-4 Moura, J.; Madureira, P.; Leal, E.C.; Fonseca, A.C.; Carvalho, E.. "Immune aging in diabetes and its implications in wound healing". Clinical Immunology 200 (2019): 43-54. http://dx.doi.org/10.1016/j.clim.2019.02.002. Published • 10.1016/j.clim.2019.02.002 DALGAARD, LOUISE T.; LEAL, ERMELINDO C.; SVENDSEN, RIKKE; MOURA, JOÃO; SØRENSEN, ANJA E.; JØRGENSEN, PER T.; CARVALHO, EUGENIA. "Effects of the Diabetes-Induced MicroRNA-155 on Wound Healing and Fibroblast Growth Factor 7 Expression". Diabetes 67 Supplement (2018): 29-LB. http://dx.doi.org/10.2337/db18-29-lb. Published • 10.2337/db18-29-lb Pereira, Sónia G.; Moura, João; Carvalho, Eugénia; Empadinhas, Nuno. "Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies". Frontiers in Microbiology 8 (2017): http://dx.doi.org/10.3389/fmicb.2017.01791. Published • 10.3389/fmicb.2017.01791 Moura, João. "Effector T-cell accumulation and reduction in TCR diversity as a promising early DFU biomarker". Diabetologia 60 (2017): S470-S471. Published • https://doi.org/10.1007/s00125-017-4350-z Alves, João; Petkovic, Marija; Anja Elaine Sørensen; Leal, Ermelindo C; Rie Juul Willemoes; P.T. Jørgensen; Jesper Wengel; Carvalho, Eugenia; Louise Torp Dalgaard. "Regulation of miRNA-146a and miR-29a during wound healing in a mouse model of type 1 diabetes". Diabetologia 60 Suppl. 1 (2017): 120-120. Published • 10.1007/s00125-017-4350-z Alves, João. "Impaired T-cell differentiation in diabetic foot ulceration.". Cellular & molecular immunology (2016): https://europepmc.org/articles/PMC5596240. 10.1038/cmi.2015.116 Moura, João. "New insights into the impaired t-cell function in diabetic foot ulcerations". Medicine 95 10 (2016): 22-22. Published • doi: 10.1097/MD.0000000000002371 Lima, Margarida; Leander, Magdalena; Santos, Marlene; Santos, Ana Helena; Lau, Catarina; Queirós, Maria Luís; Gonçalves, Marta; et al. "Chemokine Receptor Expression on Normal Blood CD56+NK-Cells Elucidates Cell Partners That Comigrate during the Innate and Adaptive Immune Responses and Identifies a Transitional NK-Cell Population". Journal of Immunology Research 2015 (2015): 1-18. http://dx.doi.org/10.1155/2015/839684. Published • 10.1155/2015/839684 Alves, João. "Challenges to Cultural Learning through International Cooperation: Festival of Sra. D’Agonia-Portugal". International Journal of Business and Social Science 6 7 (2015): 100-106. Published • DOI: 10.30845/ijbss Alves, João. "Festa Nossa Senhora d’Agonia: contributo para a análise do impacto sociocultural, ambiental e económico na sub-região do Alto Minho (Portugal)". Evidência 11 11 (2015): 189-210. https://www.uniaraxa.edu.br/ojs/index.php/evidencia/article/download/478/457. Published Moura, João; Børsheim, Elisabet; Carvalho, Eugenia. "The Role of MicroRNAs in Diabetic Complications—Special Emphasis on Wound Healing". Genes 5 4 (2014): 926-956. http://dx.doi.org/10.3390/genes5040926. Published • 10.3390/genes5040926 Moura, J.; da Silva, L.; Cruz, M. T.; Carvalho, E.. "Molecular and cellular mechanisms of bone morphogenetic proteins and activins in the skin: potential benefits for wound healing". Archives of Dermatological Research 305 7 (2013): 557-569. http://dx.doi.org/10.1007/s00403-013-1381-2. Published • 10.1007/s00403-013-1381-2 Alves, João. "Effects of domestic violence on children: a case study developed by an art teacher at a rural village in Portugal". Diálogos com a Arte 3 (2013): 318-324. https://9c6a2e0d-453e-40c4-aed1-da121f257c31.filesusr.com/ugd/6d6107_600d4ae3800d428a90b0817d660c95c5.pdf. Published MOURA, J; RODRIGUES, J; SANTOS, A; DOSANJOSTEIXEIRA, M; QUEIROS, M; SANTOS, M; GONCALVES, M; et al. "Chemokine receptor repertoire reflects mature T-cell lymphoproliferative disorder clinical presentation". Blood Cells, Molecules, and Diseases 42 1 (2009): 57-63. http://dx.doi.org/10.1016/j.bcmd.2008.08.002. Published • 10.1016/j.bcmd.2008.08.002 Costa, Elísio; Lima, Margarida; Alves, João Moura; Rocha, Susana; Rocha-Pereira, Petronila; Castro, Elisabeth; Miranda, Vasco; et al. "Inflammation, T-Cell Phenotype, and Inflammatory Cytokines in Chronic Kidney Disease Patients Under Hemodialysis and its Relationship to Resistance to Recombinant Human Erythropoietin Therapy". Journal of Clinical Immunology 28 3 (2008): 268-275. http://dx.doi.org/10.1007/s10875-007-9168-x. Published • 10.1007/s10875-007-9168-x Moura, João. "Cytokine expression of T lymphocytes and its relationship to recombinant human erythropoietin therapy in chronic renal failure patients". Cytometry Part B Clinical Cytometry 72 2 (2007): 140-141. Published • https://doi.org/10.1002/cyto.b.20170 Moura, João. "Chemokine receptor repertoire on large granular lymphocytic leukemia vs peripheral T-cell lymphoma and T-cell prolymphocytic leukemia: A comparative study". Cytometry Part B Clinical Cytometry 67 1 (2005): 46-47. Published • https://doi.org/10.1002/cyto.b.20074 Moura, João. "Human CD27+ CD28+ T cells unfold into two different populations representing different activation stages". Cytometry Part B: Clinical Cytometry 67B 1 (2005): 47-47. http://dx.doi.org/10.1002/cyto.b.20074. Published • 10.1002/cyto.b.20074 Lima, M.; Almeida, J.; Teixeira, M.A.; Santos, A.H.; Queirós, M.L.; Fonseca, S.; Moura, J.; et al. "Reactive phenotypes after acute and chronic NK-cell activation". Journal of Biological Regulators and Homeostatic Agents 18 3-4 (2004): 331-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-21144440686&partnerID=MN8TOARS. Published
Thesis / Dissertation	Alves, João. "Estudo comparativo dos mecanismos que regulam a migração e o tropismo tecidular dos linfócitos T normais e dos linfócitos T neoplásicos". PhD, Universidade do Porto, 2009. https://repositorio-aberto.up.pt/bitstream/10216/19391/2/Tese%20de%20JooAlves.pdf.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2021	O impacto do distress na distribuição das populações leucocitárias em indivíduos com úlcera do pé diabético	Sociedade Portuguesa de Diabetologia (Portugal)
2020	Nutrição e imunidade, o que precisamos para combater infeções	Sensibilização para uma alimentação saudável importante em tempos de pandemia CNC.IBILI (Portugal)
2019	BROadTHERapeutic - A new BROad THERapeutic strategy for addressing long term transplant rejection, autoimmune disease and chronic inflammatory disorders. 2nd HIR Retreat, Porto, Portugal, 2019.	2nd HIR Retreat I3S (Porto, Portugal)
2019	Saboreando a comida, molécula a molécula!	Gastronomia e Cultura Centro de Estudos Regionais de Viana do Castelo (Portugal)
2018	Novel biomarkers therapies that can tip the delicate balance in diabetic wound healing	9th Symposium on Bioengineering Universidade do Porto (Porto, Portugal)
2018	Um novo biomarcador para a úlcera diabética – resultados de um estudo longitudinal	Reunião Anual da Sociedade Portuguesa de Diabetologia Sociedade Portuguesa de Diabetologia (Vila Moura, Portugal)
2017	Impaired T-cell differentiation in diabetic foot ulceration	2nd Meeting on Biomedical Research @UC Universidade de Coimbra (Coimbra, Portugal)
2016	Accelerated aging of T-cell immunity may be a major player in diabetic foot ulcerations	1st Symposium on Aging Research Universidade de Coimbra (Coimbra, Portugal)
2015	Dissecando o papel dos LT na deficiente resposta imunitária à cicatrização de feridas diabéticas	Reunião Anual da Sociedade Portuguesa de Diabetologia Sociedade Portuguesa de Diabetologia (Tomar, Portugal)
2015	New insights into the impaired T-cell function in diabetic foot ulcerations	UMIB Summit UMIB (Porto, Portugal)
2008	HUMAN T-CELL MEMORY: TO TRULY REMEMBER OR JUST GUESS	Reunião Anual da Sociedade Portuguesa de Imunologia Sociedade Portuguesa de Imunologia (Porto, Portugal)
2007	Estudo Comparativo dos Mecanismos que Regulam a Migração e o Tropismo Tecidular dos Linfócitos T Normais e Neoplásicos - Utilidade para o Diagnóstico de Doenças Linfoproliferativas	I Jornadas de Análises Clínicas e Saúde Pública de Bragança Instituto Politécnico de Bragança (Bragança, Portugal)
2006	A new human T cell population with recent activation phenotype	Reunião Anual da Sociedade Portuguesa de Imunologia Sociedade Portuguesa de Imunologia (Braga, Portugal)
2005	HUMAN CD27+ CD28+ T CELLS UNFOLD INTO TWO DIFFERENT POPULATIONS REPRESENTING DIFFERENT ACTIVATION STAGES	5th Euroconference on Clinical Cell Analysis ESCCA (Atenas, Greece)
2005	CHEMOKINE RECEPTOR REPERTOIRE ON PERIPHERAL T-CELL LYMPHOMA AND T-CELL PROLYMPHOCYTIC LEUKAEMIA CELLS	IX Congresso da Sociedade Ibérica de Citometria Sociedade Ibérica de Citometria (Porto, Portugal)
2005	HUMAN BLOOD T AND NK CELL IN-VITRO STIMULATION REVEALS A SIMILAR ACTIVATION FENOTYPE THAT RESEMBLES EARLY ACTIVATION STAGES DURING ACUTE VIRUS INFECTION	5th Euroconference on Clinical Cell Analysis; Atenas EWGCCA (Atenas, Greece)

Event organisation

	Event name Type of event (Role)	Institution / Organization
2008 - 2008	Tertúlias Científicas de Viana do Castelo 2008 (2008 - 2008) Congress (President of the Organising Committee)	Instituto Politécnico de Viana do Castelo, Portugal
2007 - 2007	Tertúlias Científicas de Viana do Castelo 2007 (2007 - 2007) Congress (President of the Organising Committee)	Instituto Politécnico de Viana do Castelo, Portugal
2006 - 2006	Tertúlias Científicas de Viana do Castelo 2006 (2006 - 2006) Congress (President of the Organising Committee)	Instituto Politécnico de Viana do Castelo, Portugal

Distinctions

Award

2020	Pedro Eurico Lisboa 2020 honorable mention prize Sociedade Portuguesa de Diabetologia, Portugal
2020	Luís Marques SPD 2020 prize Sociedade Portuguesa de Diabetologia, Portugal
2019	Bolsa de Investigação SPT - Século XXI - Ano de 2017 Sociedade Portuguesa de Transplantação, Portugal
2019	Luís Marques – SPD 2019 prize Sociedade Portuguesa de Diabetologia, Portugal
2018	Pedro Eurico Lisboa 2018 honorable mention prize Sociedade Portuguesa de Diabetologia, Portugal
2018	Second best communication in the Portuguese Diabetes Association (SPD) congress Sociedade Portuguesa de Diabetologia, Portugal
2017	SPD/Lily grant Sociedade Portuguesa de Diabetologia, Portugal
2016	Dr. M. M. Almeida Ruas 2016 prize Sociedade Portuguesa de Diabetologia, Portugal
2016	Selected abstract at the 1st Symposium on Aging Research CNC.IBILI, Portugal Universidade de Coimbra, Portugal
2016	Forum Hematológico do Norte prize for the publication of the “Impaied T-cell differentiation in diabetic foot ulcerations” paper Forum Hematológico do Norte, Portugal
2015	Best communication in the Multidisciplinary Unit of Biomedical Investigation (UMIB) congress Universidade do Porto Unidade Multidisciplinar de Investigação Biomédica, Portugal
2015	Best communication in the Portuguese Diabetes Association congress Sociedade Portuguesa de Diabetologia, Portugal

Other distinction

2017	Pos-doc scholarship in the HEALTHY AGING 2020 project Fundação para a Ciência e a Tecnologia, Portugal
2007	PhD scholarship Fundação para a Ciência e a Tecnologia, Portugal
2006	Personal scholarship from "Forum Hematológico do Norte" Forum Hematológico do Norte, Portugal
2004	Personal scholarship from Novartis/GHOP Novartis AG, Switzerland
2002	Erasmus scholarship Universidade do Porto, Portugal