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Andreia Pereira Barateiro Macedo. Concluiu o Doutoramento em Farmácia, especialidade em Biologia Celular e Molecular e Celular em 2012 pela Universidade de Lisboa, Faculdade de Farmácia, o Mestrado em Biotecnologia em 2008 pela Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia e a Licenciatura em Química Aplicada, Ramo Biotecnologia em 2005 pela Universidade Nova de Lisboa, Faculdade de Ciências e Tecnologia. É Investigador no Instituto do Medicamento, Universidade de Lisboa (iMed.ULisboa). Publicou 28 artigos em revistas especializadas. Possui 1 capítulo de livro. Coorientou 3 dissertações de mestrado. Recebeu 3 prémios. Participa e/ou participou como Investigador em 6 projetos.
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Identification

Personal identification

Full name
Andreia Pereira Barateiro Macedo

Citation names

  • Barateiro, Andreia

Author identifiers

Ciência ID
F01C-E625-FA82
ORCID iD
0000-0002-0378-4854
Researcher Id
I-5746-2014
Scopus Author Id
22940127500

Email addresses

  • apb@ff.ulisboa.pt (Professional)

Telephones

Fax
  • 217946491 (Professional)
Telephone
  • 217946400 (Professional)

Addresses

  • Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, Universidade de Lisboa. Av. Professor Gama Pinto, 1649-003, Lisboa, Lisboa, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2019
Concluded
 CONGENTO "Upgrade to new Function B (according to FELASA new cat. B) (Outros)
Fundação Champalimaud, Portugal
2015
Concluded
 Course on Animal Handling and Experimentation at mice and zebrafish (according to FELASA new cat. A) (Outros)
Major in Animal Handling and Experimentation
Instituto Gulbenkian de Ciência, Portugal
2008 - 2012
Concluded
 Pharmacy (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Bilirubin dysregulates myelination in early neonatal life" (THESIS/DISSERTATION)
 Distinção e louvor (Magna cum laude)
2007 - 2008
Concluded
 Biotecnologia (Mestrado)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Epidemiology of genital infection from human papilomavirus (HPV) and study of prognostic indicators. Importance in cervical cancer prevention" (THESIS/DISSERTATION)
 17 (seventeen) values
2000 - 2005
Concluded
 Química Aplicada (Licenciatura)
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
"Characterization of resistance mechanisms to beta-lactamic antibiotics in Haemophilus influenza strands" (THESIS/DISSERTATION)
 15 (fifteen) values
Affiliation

Science

Category
Host institution 		Employer
2019/02/18 - Current Researcher (Research) Universidade de Lisboa Faculdade de Farmácia, Portugal
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Others

Category
Host institution 		Employer
2014/04/01 - 2019/02/17 Postdoctoral fellow position. Project: "The role of S100B in Multiple Sclerosis: from a biomarker to a therapeutic target". Supervisors: Adelaide Fernandes, Jack van Horssen and João J. Cerqueira Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2013/01/02 - 2013/07/31 Postdoc fellow. Project "S100B in CNS myelination and re-myelination: a target for therapeutic intervention on demyelinating disorders", funded by Medal of Honor for Women in Science Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2008/10/01 - 2012/10/25 PhD Student. Project: "How far is oligodendrocyte maturation and function compromised by perinatal risk factors?". Supervisors: Professor Dora Brites and Professor Adelaide Fernandes Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2007/10/01 - 2008/09/30 Research fellow in the project PTDC/SAU-NEU/64385/2006, entitled "Uncovering the potential neurodevelopmental deficits in common neonatal conditions such as hyperbilirubinemia and inflammation" Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2006/12/01 - 2007/09/30 Master Student. Project: "Epidemiologia da infecção genital pelo Vírus do Papiloma Humano e estudos dos indicadores de prognóstico. Importância na prevenção do colo do útero". Supervisor: Ângela Pista Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
2006/02/01 - 2006/10/31 Research fellow. Project: "Estudo da resistência ao oxigénio da bactéria sulfato-redutora Desulfovibrio vulgaris". Supervisor: Margarida Santana Universidade de Lisboa Faculdade de Ciências, Portugal
2005/01/03 - 2005/10/31 Research trainee. Project: "Caracterização dos Mecanismos de Resistência aos Antibióticos beta-lactâmicos em Estirpes de Haemophilus influenzae. Supervisors: Manuela Caniço and Paula Lavado Instituto Nacional de Saúde Doutor Ricardo Jorge, Portugal
Projects

Contract

Designation Funders
2022/01/01 - Current Interplay between innate and acquired immune response at the basis for Multiple Sclerosis cognitive deficits
PTDC-MED-PAT-2582-2021
Researcher
Fundação para a Ciência e a Tecnologia
2022/01/01 - 2023/12/31 Role of obesity in multiple sclerosis: oligodendrocyte-related miRNAs as new targets to induce remyelination
EXPL-MED-NEU-1033-2021
Principal investigator
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2018/09/01 - 2022/12/31 Targeting multiple sclerosis immune- and psycho-pathophysiology by modulation of neuroinflammation
GMSI2017
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
 Merck KGaA
2016 - 2018 Generation of improved cellular and animal models for identification of disease phenotype and new therapeutic targets of Alzheimer's disease
JPCOFUND/0003/2015
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2016 - 2018 Identification and assessment of new psychoactive substances: a European network
JUST/2014/JDRUG/AG/DRUG
Researcher
Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Concluded
2015 - 2017 Optogenetic dissection of neural circuits controlling adiposity
PTDC/BIM-MET/3750/2014
Researcher
Instituto Gulbenkian de Ciência, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2015 - 2016 Evaluation of the impact of ingredients on myelination markers in an ex vivo cerebellar slice culture mode
Nestle2014
Researcher
Nestlé Lausanne
Concluded
2011 - 2014 ARE MICROGLIA A NEW POTENTIAL PHARMACOLOGICAL TARGET IN AMYOTROPHIC LATERAL SCLEROSIS (ALS)?
PTDC/SAU-FAR/118787/2010
Researcher
Fundação para a Ciência e a Tecnologia
Concluded
2006 - 2010 Uncovering the potential neurodevelopmental deficits in commun neonatal conditions such as hyperbilirrubinemia and inflammation
PTDC/SAU-NEU/64385/2006
Researcher
Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2013 - 2014 Role of S100B in multiple sclerosis: from a biomarker to a therapeutic target
Ordem Farmaceuticos2013
Researcher
Ordem dos Farmaceuticos
Concluded
Outputs

Publications

Book chapter
  1. Macedo, Andreia; Santos Gisela; Afonso Vera; Brites, Dora; Fernandes, Adelaide. "Role of S100B on Oligodendrocyte Physiology and Pathology". In Oligodendrocytes: Biology, Functions and Role in the Pathology of Diseases. Nova Science Publishers, 2015.
  2. Barateiro, A.; Santos, G.; Afonso, V.; Brites, D.; Fernandes, A.. "Role of S100B on oligodendrocyte physiology and pathology". 111-163. 2015.
Conference paper
  1. Barros, Catarina; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "Target S100B prevents in vivo MS-like pathology". 2019.
    Published
  2. Barateiro, Andreia; Barros, Catarina; Soromenho, Beatriz; Basto, Afonso; Freitas, Raquel; Brites, Dora; Graça, Luís; Fernandes, Adelaide. "S100B has a crucial role in inflammation and immune response in the in vivo model of Multiple Sclerosis". 2019.
    10.3389/conf.fncel.2019.01.00052
  3. Barros, C.; Pascoal, P.; Santos, G.; Barateiro, A.; Freitas, R.; Brites, D.; Graça, L.; Fernandes, A.. "Inhibition of S100B prevents ex vivo demyelination and improves EAE clinical score". 2018.
    Published • 10.1016/j.freeradbiomed.2018.04.504
  4. Barros, Catarina; Pascoal, Pedro; Santos, Gisela; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "S100B blockage prevents ex vivo demyelination and ameliorates EAE clinical score". 2018.
    Published
Conference poster
  1. Neto, Alexandre; Alberro, Ainhoa; Barros, Catarina; Ribeiro, Ana Rita; Fernandes, Adelaide; Barateiro, Andreia. "Obesity-driven changes in CNS pathology leads to a more aggressive phenotype in an animal model of multiple sclerosis.". Paper presented in 39th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 2023.
  2. Neto, Alexandre; Alberro, Ainhoa; Barros, Catarina; Ribeiro, Ana Rita; Fernandes, Adelaide; Barateiro, Andreia. "Exploring the impact of obesity on multiple sclerosis severity: an in vivo model unveiling aggressive clinical progression". Paper presented in 14th iMed.ULisboa Posgraduate Students Meeting, 2023.
  3. Alexandre Neto; Alberro, Ainhoa; Barros, Catarina; Ana Rita Macário Ribeiro (1916-B3D3-8535); Fernandes, Adelaide; Barateiro, Andreia. "Obesity induces a more aggressive clinical course in an animal model of multiple sclerosis". Paper presented in FENS FRM 2023, 2023.
  4. Alexandre Neto; Alberro, Ainhoa; Barros, Catarina; Ana Rita Macário Ribeiro (1916-B3D3-8535); Fernandes, Adelaide; Barateiro, Andreia. "Exploring the adverse effects of obesity on clinical progression and CNS pathogenesis of multiple sclerosis: an in vivo model study". Paper presented in VII Symposium of the Portuguese Glial Network, 2023.
  5. Ribeiro AR; Pereira R; Barros, Catarina; Barateiro, Andreia; Fernandes, Adelaide. "Impact of age in the central nervous system pathogenesis of the in vivo model of multiple sclerosis". Paper presented in 38th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 2022.
  6. Leitão M; Barros, Catarina; Florindo P; Moreira R; Brites, Dora; Lopes A; Fernandes, Adelaide; Cristina De Mello-Sampayo. "Age-related impact of 4-chloroethcathinone on the central nervous system: addressing animal behavior, neuroinflammation and neurodegeneration". Paper presented in 13th iMed.ULisboa Posgraduate Students Meeting, 2022.
  7. Pereira R; Ribeiro AR; Barros, Catarina; Barateiro, Andreia; Howlett, Susan E; Fernandes, Adelaide. "A comparative study of regional demyelinated lesions along age in an in vivo model of Multiple Sclerosis". Paper presented in 13th iMed.ULisboa Posgraduate Students Meeting, 2022.
  8. Grilo C; Leitão M; Gamito C; Barros, Catarina; Barateiro, Andreia; Florindo P; Moreira R; et al. "Neuronal and behavioral alterations after young mice intake of N-ethylpentylone". Paper presented in 13th iMed.ULisboa Posgraduate Students Meeting, 2022.
  9. Ribeiro AR; Barros, Catarina; VazPinto, Maria; Leitão M; Alberro, Ainhoa; Barateiro, Andreia; Susan E Howllet; Fernandes, Adelaide. "Vamos desmistificar a Esclerose Múltipla". Paper presented in 1ª Edição Jornadas Científicas da Universidade de Lisboa, 2022.
  10. Ribeiro AR; Pereira R; Barros, Catarina; Barateiro, Andreia; Susan E Howllet; Fernandes, Adelaide. "The influence of age in the pathogenesis of Multiple Sclerosis using an in vivo model". Paper presented in Ciência 2022 – Encontro com a Ciência e Tecnologia em Portugal, 2022.
  11. Barros, Catarina; Neto, Alexandre; Barateiro, Andreia; Fernandes, Adelaide. "S100B deletion protects from Multiple Sclerosis-like pathology.". Paper presented in V Symposium of the Portuguese Glial Network, 2021.
  12. Ana Rita Macário Ribeiro (1916-B3D3-8535); Barros, Catarina; Barateiro, Andreia; Howlett, Susan E; Fernandes, Adelaide. "A novel approach to better understand phenotypic alterations in the in vivo model of Multiple Sclerosis at distinct mice age - improved Frailty Index scale.". Paper presented in 37th Annual Congress of ECTRIMS, 2021.
  13. Barros, Catarina; Barateiro, Andreia; Basto, Afonso P.; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "S100B neutralization modulates Multiple Sclerosis-like pathogenesis.". Paper presented in iMed.ULisboa Meeting, 2021.
  14. Barros, Catarina; Barateiro, Andreia; Basto, Afonso P.; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "S100B neutralization modulates T cell immune response in the in vivo model of Multiple Sclerosis". Paper presented in Conte Center Symposium on Neuro-Immune Interactions, 2021.
  15. Ana Rita Macário Ribeiro (1916-B3D3-8535); Barros, Catarina; Barateiro, Andreia; Basto, Afonso P.; Graca, Luis; Howlett, Susan E; Fernandes, Adelaide. "Understanding age-associated changes in immune cell response in an in vivo model of Multiple Sclerosis". Paper presented in Conte Center Symposium on Neuro-Immune Interactions, 2021.
  16. Barros, Catarina; Barateiro, Andreia; Soromenho, Beatriz; Basto, Afonso; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "Pentamidine as new therapeutic strategy against multiple sclerosis-like pathology". Paper presented in 8th Joint ACTRIMS-ECTRIMS Meeting, 2020.
  17. Soromenho, Beatriz; Barros, Catarina; Barateiro, Andreia; Basto, Afonso P.; Freitas, Raquel; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "S100B as a crucial player in Multiple Sclerosis neuroinflammation and immunopathogenesis". Paper presented in 5th Mind-Brain College and 17th Biomedical Engineering Meeting, 2019.
  18. Soromenho, Beatriz; Barros, Catarina; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "S100B specific inhibition prevent CNS damage and inflammation in the in vivo model of Multiple Sclerosis". Paper presented in 11th Postgraduate iMed.ULisboa Students Meeting & 4 i3DU Meeting, 2019.
  19. Barros, Catarina; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "S100B plays an active role in the pathogenesis of the in vivo model of Multiple Sclerosis". Paper presented in IV European Meeting on Glial Cells in Health and Disease, 2019.
  20. Soromenho, Beatriz; Barros, Catarina; Barateiro, Andreia; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "Role of astroglial-derived S100B during demyelination of the Multiple Sclerosis in vivo EAE model". Paper presented in IV Symposium of the Portuguese Glial Network, 2019.
  21. Barros, Catarina; Barateiro, Andreia; Soromenho, Beatriz; Basto, Afonso; Freitas, Raquel; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "S100B targeting change the inflammatory and imune profile of the in vivo model of Multiple Sclerosis". Paper presented in IV Symposium of the Portuguese Glial Network, 2019.
  22. Barros, Catarina; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "Targeting S100B prevents in vivo Multiple Sclerosis-like pathology". Paper presented in 5th International Porto Congress of Multiple Sclerosis, 2019.
  23. Barateiro, Andreia; Barros, Catarina; Pascoal, Pedro; Santos, Gisela; Freitas, Raquel; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "Targeting S100B reduces demyelination-associated pathogenesis in ex vivo and in vivo models mimicking Multiple Sclerosis". Paper presented in 34th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 2018.
  24. Santos, Gisela; Barateiro, Andreia; Brites, Dora; Fernandes, Adelaide. "S100B-RAGE signalling affect de novo myelination and remyelination". Paper presented in XIII European Meeting on Glial Cells in Health and Disease, 2017.
  25. Barros, Catarina; Pascoal, Pedro; Santos, Gisela; Barateiro, Andreia; Freitas, Raquel; Brites, Dora; Graca, Luis; Fernandes, Adelaide. "Inhibition of S100B prevents ex vivo demyelination and improves EAE clinical score". Paper presented in 19th biennial meeting for the Society for Free Radical Research International (SFRRI), 2017.
  26. Pascoal, Pedro; Santos, Gisela; Barateiro, Andreia; Brites, Dora; CERQUEIRA, JOÃO JOSE; Fernandes, Adelaide. "S100B-RAGE axis is increased in Experimental Autoimmune Encephalomyelitis and reduced upon dimethyl fumarate treatment". Paper presented in XV Portuguese Society for Neuroscience, 2017.
  27. Santos, Gisela; Barateiro, Andreia; Brites, Dora; Fernandes, Adelaide. "S100B-RAGE axis as a regulator of oligodendrogenesis". Paper presented in XIX National Congress of Biochemistry, 2016.
  28. Barateiro, Andreia; Afonso, Vera; Ferreira, Carla; Santos, Gisela; CERQUEIRA, JOÃO JOSE; Brites, Dora; van Horssen, J.; Fernandes, Adelaide. "Multiple sclerosis: implications of high S100B levels in demyelination and glia reactivity". Paper presented in 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 2015.
  29. Santos, Gisela; Barateiro, Andreia; Brites, Dora; Fernandes, Adelaide. "Elevated levels of S100B impair oligodendrogenesis". Paper presented in 31st Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), 2015.
  30. Santos, Gisela; Afonso, Vera; Barateiro, Andreia; Brites, Dora; Fernandes, Adelaide. "S100B modulates oligodendrocyte development process". Paper presented in XII European Meeting on Glial Cells in Health and Disease, 2015.
  31. Santos, Gisela; Barateiro, Andreia; Brites, Dora; Fernandes, Adelaide. "S100B affects oligodendrocyte differentiation and maturation processes". Paper presented in XIV Metting of the Portuguese Society for Neurosciences, 2015.
  32. Barateiro, Andreia; Afonso, Vera; Santos, Gisela; CERQUEIRA, JOÃO JOSE; Brites, Dora; van Horssen, J.; Fernandes, Adelaide. "S100B is a key player in multiple sclerosis pathology". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  33. Barateiro, Andreia; Afonso, Vera; Santos, Gisela; CERQUEIRA, JOÃO JOSE; Brites, Dora; van Horsen, J; Fernandes, Adelaide. "S100B levels are increased in multiple sclerosis and modulates demyelination, glial reactivity and inflammation". Paper presented in 6th Joint ACTRIMS-ECTRIMS Meeting, 2014.
  34. Ribeiro, Maria H; Barateiro, Andreia; Vila-Real, H; Fernandes, Adelaide; Brites, Dora. "Anti-inflammatory Effect of naringin and naringenin on TNF-a secretion in cultured cortical astrocytes after stimulation with LPS". Paper presented in ECB 2014, 2014.
Journal article
  1. Rodrigues, R. S.; Moreira, J. B.; Mateus, J. M.; Barateiro, A.; Paulo, S. L.; Vaz, S. H.; Lourenço, D. M.; et al. "Cannabinoid type 2 receptor inhibition enhances the antidepressant and proneurogenic effects of physical exercise after chronic stress". Translational Psychiatry 14 1 (2024): http://dx.doi.org/10.1038/s41398-024-02877-0.
    10.1038/s41398-024-02877-0
  2. da Silva, Inês V.; Pimpão, Catarina; Paccetti-Alves, Inês; Thomas, Sophie R.; Barateiro, Andreia; Casini, Angela; Soveral, Graça. "Blockage of aquaporin-3 peroxiporin activity by organogold compounds affects melanoma cell adhesion, proliferation and migration". The Journal of Physiology (2024): http://dx.doi.org/10.1113/jp284155.
    Accepted • 10.1113/jp284155
  3. Ribeiro, Ana Rita; Pereira, Raquel; Barros, Catarina; Barateiro, Andreia; Alberro, Ainhoa; Afonso Pinto Basto; Graca, Luis; et al. "Age impacts Experimental Autoimmune Encephalomyelitis pathogenesis: focus on S100B temporal Effect". Journal of Neuroinflammation (2024):
    Under revision
  4. Neto, Alexandre; Fernandes, Adelaide; Barateiro, Andreia. "The complex relationship between obesity and neurodegenerative diseases: an updated review". Frontiers in Cellular Neuroscience 17 (2023): http://dx.doi.org/10.3389/fncel.2023.1294420.
    Published • 10.3389/fncel.2023.1294420
  5. Barateiro, Andreia; Barros, Catarina; Pinto, Maria V.; Ribeiro, Ana Rita; Alberro, Ainhoa; Fernandes, Adelaide. "Women in the field of multiple sclerosis: How they contributed to paradigm shifts". Frontiers in Molecular Neuroscience 16 (2023): http://dx.doi.org/10.3389/fnmol.2023.1087745.
    10.3389/fnmol.2023.1087745
  6. Acúrcio RC; Pozzi S; Carreira B; Pojo M; Gómez-Cebrián N; Casimiro S; Fernandes A; et al. "Therapeutic targeting of PD-1/PD-L1 blockade by novel small-molecule inhibitors recruits cytotoxic T cells into solid tumor microenvironment.". Journal for immunotherapy of cancer (2022): http://europepmc.org/abstract/med/35863821.
    10.1136/jitc-2022-004695
  7. Barros C; Barateiro A; Neto A; Soromenho B; Basto AP; Mateus JM; Xapelli S; et al. "S100B inhibition protects from chronic experimental autoimmune encephalomyelitis.". Brain communications (2022): http://europepmc.org/abstract/med/35620168.
    10.1093/braincomms/fcac076
  8. Ribeiro, Ana Rita; Barros, Catarina; Barateiro, Andreia; Howlett, Susan E; Fernandes, Adelaide. "Improved Assessment of Overall Health in Variably Aged Murine Models of Multiple Sclerosis With a Novel Frailty Index Tool". The Journals of Gerontology: Series A 77 1 (2021): 1-9. http://dx.doi.org/10.1093/gerona/glab185.
    10.1093/gerona/glab185
  9. Santos, Gisela; Barateiro, Andreia; Brites, Dora; Fernandes, Adelaide. "S100B Impairs Oligodendrogenesis and Myelin Repair Following Demyelination Through RAGE Engagement". Frontiers in Cellular Neuroscience 14 (2020): http://dx.doi.org/10.3389/fncel.2020.00279.
    Published • 10.3389/fncel.2020.00279
  10. Mahú, Inês; Barateiro, Andreia; Rial-Pensado, Eva; Martinéz-Sánchez, Noelia; Vaz, Sandra H.; Cal, Pedro M.S.D.; Jenkins, Benjamin; et al. "Brain-Sparing Sympathofacilitators Mitigate Obesity without Adverse Cardiovascular Effects". Cell Metabolism 31 6 (2020): 1120-1135.e7. http://dx.doi.org/10.1016/j.cmet.2020.04.013.
    Published • 10.1016/j.cmet.2020.04.013
  11. Santos, G.; Barateiro, A.; Gomes, C.M.; Brites, D.; Fernandes, A.. "Impaired oligodendrogenesis and myelination by elevated S100B levels during neurodevelopment". Neuropharmacology 129 (2018): 69-83. http://www.scopus.com/inward/record.url?eid=2-s2.0-85034070602&partnerID=MN8TOARS.
    10.1016/j.neuropharm.2017.11.002
  12. Caldeira C; Cunha C; Vaz AR; Falcão AS; Barateiro A; Seixas E; Fernandes A; Brites D. "Key Aging-Associated Alterations in Primary Microglia Response to Beta-Amyloid Stimulation.". Frontiers in aging neuroscience (2017): http://europepmc.org/abstract/med/28912710.
    10.3389/fnagi.2017.00277
  13. Barateiro, A.; Mahú, I.; Domingos, A.I.. "Leptin resistance and the neuro-adipose connection". Frontiers in Endocrinology 8 MAR (2017): http://www.scopus.com/inward/record.url?eid=2-s2.0-85017107612&partnerID=MN8TOARS.
    10.3389/fendo.2017.00045
  14. Barateiro A; Brites D; Fernandes A. "Oligodendrocyte Development and Myelination in Neurodevelopment: Molecular Mechanisms in Health and Disease.". Current pharmaceutical design (2016): http://europepmc.org/abstract/med/26635271.
    10.2174/1381612822666151204000636
  15. Barateiro, A.; Chen, S.; Yueh, M.-F.; Fernandes, A.; Domingues, H.S.; Relvas, J.; Barbier, O.; et al. "Reduced myelination and increased glia reactivity resulting from severe neonatal hyperbilirubinemia". Molecular Pharmacology 89 1 (2016): 84-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958151344&partnerID=MN8TOARS.
    10.1124/mol.115.098228
  16. Barateiro, A.; Afonso, V.; Santos, G.; Cerqueira, J.J.; Brites, D.; van Horssen, J.; Fernandes, A.. "S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis". Molecular Neurobiology 53 6 (2016): 3976-3991. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937132572&partnerID=MN8TOARS.
    10.1007/s12035-015-9336-6
  17. Rocha J; Eduardo-Figueira M; Barateiro A; Fernandes A; Brites D; Pinto R; Freitas M; et al. "Erythropoietin reduces acute lung injury and multiple organ failure/dysfunction associated to a scald-burn inflammatory injury in the rat.". (2015): http://europepmc.org/abstract/med/25270658.
    10.1007/s10753-014-0035-7
  18. Rocha, J.; Eduardo-Figueira, M.; Barateiro, A.; Fernandes, A.; Brites, D.; Bronze, R.; Duarte, C.M.; et al. "Anti-inflammatory effect of rosmarinic acid and an extract of rosmarinus officinalis in rat models of local and systemic inflammation". Basic and Clinical Pharmacology and Toxicology 116 5 (2015): 398-413. http://www.scopus.com/inward/record.url?eid=2-s2.0-84926358222&partnerID=MN8TOARS.
    10.1111/bcpt.12335
  19. Zeng, W.; Pirzgalska, R.M.; Pereira, M.M.A.; Kubasova, N.; Barateiro, A.; Seixas, E.; Lu, Y.-H.; et al. "Sympathetic Neuro-adipose Connections Mediate Leptin-Driven Lipolysis". Cell 163 1 (2015): 84-94. http://www.scopus.com/inward/record.url?eid=2-s2.0-84944733460&partnerID=MN8TOARS.
    10.1016/j.cell.2015.08.055
  20. Rocha J; Figueira ME; Barateiro A; Fernandes A; Brites D; Pinto R; Freitas M; et al. "Inhibition of Glycogen Synthase Kinase 3ß (GSK-3ß) Attenuates Organ Injury and Dysfunction Associated to Liver Ischemia-Reperfusion and Thermal Injury in the Rat.". (2014): http://europepmc.org/abstract/med/25394244.
    10.1097/SHK.0000000000000298
  21. Ratilal, B.O.; Arroja, M.M.C.; Rocha, J.P.F.; Fernandes, A.M.A.; Barateiro, A.P.; Brites, D.M.T.O.; Pinto, R.M.A.; Sepodes, B.M.N.; Mota-Filipe, H.D.. "Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion: Laboratory investigation". Journal of Neurosurgery 121 1 (2014): 55-62. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903879102&partnerID=MN8TOARS.
    10.3171/2014.2.JNS132197
  22. Falcão, A.S.; Silva, R.F.M.; Vaz, A.R.; Gomes, C.; Fernandes, A.; Barateiro, A.; Tiribelli, C.; Brites, D.. "Cross-talk between neurons and astrocytes in response to bilirubin: Adverse secondary impacts". Neurotoxicity Research 26 1 (2014): 1-15. http://www.scopus.com/inward/record.url?eid=2-s2.0-84903741375&partnerID=MN8TOARS.
    10.1007/s12640-013-9427-y
  23. Barateiro, A.; Fernandes, A.. "Temporal oligodendrocyte lineage progression: In vitro models of proliferation, differentiation and myelination". Biochimica et Biophysica Acta - Molecular Cell Research 1843 9 (2014): 1917-1929. http://www.scopus.com/inward/record.url?eid=2-s2.0-84902532010&partnerID=MN8TOARS.
    10.1016/j.bbamcr.2014.04.018
  24. Ratilal, B.O.; Rocha, J.P.F.; Fernandes, A.M.A.; Arroja, M.M.C.; Barateiro, A.P.; Brites, D.M.T.O.; Pinto, R.M.A.; Sepodes, B.M.N.; Mota-Filipe, H.D.. "TDZD-8 pre-treatment in transient middle cerebral artery occlusion". Biomedicine and Aging Pathology 4 4 (2014): 361-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908333539&partnerID=MN8TOARS.
    10.1016/j.biomag.2014.07.005
  25. Barateiro, A.; Domingues, H.S.; Fernandes, A.; Relvas, J.B.; Brites, D.. "Rat cerebellar slice cultures exposed to bilirubin evidence reactive gliosis, excitotoxicity and impaired myelinogenesis that is prevented by AMPA and TNF-a inhibitors". Molecular Neurobiology 49 1 (2014): 424-439. http://www.scopus.com/inward/record.url?eid=2-s2.0-84894373448&partnerID=MN8TOARS.
    10.1007/s12035-013-8530-7
  26. Barateiro A; Miron VE; Santos SD; Relvas JB; Fernandes A; Ffrench-Constant C; Brites D. "Unconjugated bilirubin restricts oligodendrocyte differentiation and axonal myelination.". (2013): http://europepmc.org/abstract/med/23086523.
    10.1007/s12035-012-8364-8
  27. Barateiro, A.; Vaz, A.R.; Silva, S.L.; Fernandes, A.; Brites, D.. "ER stress, mitochondrial dysfunction and calpain/jnk activation are involved in oligodendrocyte precursor cell death by unconjugated bilirubin". NeuroMolecular Medicine 14 4 (2012): 285-302. http://www.scopus.com/inward/record.url?eid=2-s2.0-84870563054&partnerID=MN8TOARS.
    10.1007/s12017-012-8187-9
  28. Silva, S.L.; Osório, C.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Silva, R.F.M.; Brites, D.. "Dynamics of neuron-glia interplay upon exposure to unconjugated bilirubin". Journal of Neurochemistry 117 3 (2011): 412-424. http://www.scopus.com/inward/record.url?eid=2-s2.0-79954420884&partnerID=MN8TOARS.
    10.1111/j.1471-4159.2011.07200.x
  29. Fernandes, A.; Barateiro, A.; Falcão, A.S.; Silva, S.L.-A.; Vaz, A.R.; Brito, M.A.; Marques Silva, R.F.; Brites, D.. "Astrocyte reactivity to unconjugated bilirubin requires TNF-a and IL-1ß receptor signaling pathways". GLIA 59 1 (2011): 14-25. http://www.scopus.com/inward/record.url?eid=2-s2.0-78349235777&partnerID=MN8TOARS.
    10.1002/glia.21072
  30. Vaz, A.R.; Silva, S.L.; Barateiro, A.; Fernandes, A.; Falcão, A.S.; Brito, M.A.; Brites, D.. "Pro-inflammatory cytokines intensify the activation of NO/NOS, JNK1/2 and caspase cascades in immature neurons exposed to elevated levels of unconjugated bilirubin". Experimental Neurology 229 2 (2011): 381-390. http://www.scopus.com/inward/record.url?eid=2-s2.0-79956137679&partnerID=MN8TOARS.
    10.1016/j.expneurol.2011.03.004
  31. Vaz, A.R.; Silva, S.L.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Brites, D.. "Selective vulnerability of rat brain regions to unconjugated bilirubin". Molecular and Cellular Neuroscience 48 1 (2011): 82-93. http://www.scopus.com/inward/record.url?eid=2-s2.0-79960929537&partnerID=MN8TOARS.
    10.1016/j.mcn.2011.06.008
  32. Silva, S.L.; Vaz, A.R.; Barateiro, A.; Falcão, A.S.; Fernandes, A.; Brito, M.A.; Silva, R.F.M.; Brites, D.. "Features of bilirubin-induced reactive microglia: From phagocytosis to inflammation". Neurobiology of Disease 40 3 (2010): 663-675. http://www.scopus.com/inward/record.url?eid=2-s2.0-77957807564&partnerID=MN8TOARS.
    10.1016/j.nbd.2010.08.010
  33. Pista, A.; Oliveira, A.; Barateiro, A.; Costa, H.; Verdasca, N.; Paixão, M.T.. "Molecular variants of human papillomavirus type 16 and 18 and risk for cervical neoplasia in Portugal". Journal of Medical Virology 79 12 (2007): 1889-1897. http://www.scopus.com/inward/record.url?eid=2-s2.0-35549000463&partnerID=MN8TOARS.
    10.1002/jmv.21002
Thesis / Dissertation
  1. Barateiro, Andreia Pereira, 1982-. "Bilirubin dysregulates myelination in early neonatal life". PhD, 2012. http://hdl.handle.net/10451/7264.
  2. Barateiro, Andreia. "Epidemiology of genital infection from human papillomavirus (HPV) and study of prognostic indicators. Importance in cervical cancer prevention". Master, Instituto Nacional de Saúde Doutor Ricardo Jorge, 2007.
  3. Barateiro, Andreia. "Characterization of resistance mechanisms to beta-lactamic antibiotics in Haemophilus influenza strands". Degree, Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, 2005.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/02 In Vivo Exploration of Obesity's Influence on the Severity of Multiple Sclerosis: A Comprehensive Analysis of Clinical Progression 54th Meeting of the Portuguese Society of Pharmacology
NOVA Medical School (Portugal)
2023/05 Inflammation: a multiple sclerosis and obesity link The Young Investigator Seminar Series
iMed.ULisboa (Portugal)
2022/10/18 Alterations in CNS Pathogenesis of the In Vivo Model of Multiple Sclerosis: Age Impact VI Symposium of the Portuguese Glial Network
2022/07/04 The impact of age in the in vivo model of Multiple Sclerosis: insights in overall health, spinal cord pathology and gut microbiome 13th iMed.ULisboa Posgraduate Students Meeting
2022/02/09 The impact of age in the glial-immune interplay using the in vivo model of Multiple Sclerosis 52nd Meeting of Portuguese Society of Pharmacology
2021/02/17 Pentamidine prevents multiple sclerosis-like pathogenesis by neutralizing S100B toxic effects 2021 Meeting of the Portuguese Society of Pharmacology
(Portugal)
2021/02/17 Improved frailty index scale in in vivo model of multiple sclerosis: a novel approach to better understand phenotypic alterations in distinct mice age 2021 Meeting of the Portuguese Society of Pharmacology
(Portugal)
2021/02/17 A new pharmacological approach to prevent synaptic loss and promote myelin phagocytosis: A step forward to modulate cognitive impairment and remyelination in MS 2021 Meeting of the Portuguese Society of Pharmacology
(Portugal)
2021/02/17 Nanobody-based strategies to target S100B and improve recovery in an ex vivo demyelinating model 2021 Meeting of the Portuguese Society of Pharmacology
(Portugal)
2020 Oligodendrocytes: Biology, functions and pathology Master's degree in Biopharmaceutical Sciences
Faculdade de Farmácia, Universidade de Lisboa
2019/06/01 S100B has crucial role in neuroinflammation and immune response in the in vivo model of Multiple Sclerosis XIV Meeting of the Portuguese Society for Neuroscience
(Portugal)
2019/02/15 Targeting S100B prevents in vivo Multiple Sclerosis-like pathology. 5th International Porto Congress of Multiple Sclerosis
(Portugal)
2018/05/18 S100B blockage prevents ex vivo demyelination and ameliorates EAE clinical score Reunião de Primavera do Grupo de Estudos de Esclerose Múltipla: “A caminho da personalização? Novas perspetivas no tratamento e monitorização na esclerose múltipla centradas no doente”
(Portugal)
2018/02/05 Involvement of S100B-RAGE axis in myelin damage associated with inflammatory conditions: dysmyelination vs. demyelination 2018 Meeting of the Portuguese Society of Pharmacology
(Portugal)
2017/10/09 Targeting neuroinflammation in Multiple Sclerosis Lisbon Area of Neuroscience Meeting
Instituto de Medicina Molecular (Portugal)
2017/05/04 Targeting neuroinflammation in Multiple Sclerosis 4th Annual Conference of Rede Saúde
(Lisboa, Portugal)
2017/03/09 S100B a new inflammatory target in Multiple Sclerosis 4th International Porto Congress of Multiple Sclerosis 2017
(Portugal)
2016/12/08 Aß Treatment Promotes Microglia Desensitization and Induces Multiple Phenotypes XIX National Congress of Biochemistry
(Portugal)
2014/05/24 Temporal oligodendrocyte lineage progession: experimental models to study myelination and demyelination VII Ciclo de Scienceshops about Multiple Sclerosis
2014/05/24 Temporal oligodendrocyte lineage progression: experimental models to study myelination and demyelination VII Ciclo de Scienceshops about Multiple Sclerosis
(Portugal)
2013/05/30 Unconjugated bilirubin dysregulates oligodendrocyte development and myelinogenesis XIII Meeting of the Portuguese Neuroscience Society
2013/01/14 Potential harmful effects of bilirubin in oligodendrocyte development and myelination Lisbon Area of Neuroscience Meeting
2011/06/06 Potential harmful effects of bilirubin in myelogenesis Trieste Yellow Retreat

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2023/10/01 - 2024/10 Effects of obesity in multiple sclerosis pathogenesis: oligodendrocyte development, myelination and glia reactivity
Supervisor
Universidade de Lisboa Faculdade de Ciências, Portugal
2023/11 - 2024/09/30 Obesidade como fator de risco para o desenvolvimento/progressão de doenças
Supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/01/03 - 2023/06/30 Effects of obesity in multiple sclerosis pathogenesis: glia reactivity
Supervisor
Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2022/09/01 - 2023 New in vitro model of microglia-derived from human PBMCs to unravel their contribution in neurodegenerative disorders
Co-supervisor
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/09/24 - 2022 Detection of Age-associated Changes of the Targets of Diseease Modifying Therapies in Multiple Sclerosis
Co-supervisor
 Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2017 - 2018 Target S100B to reduce Experimental Autoimmune Encephalomyelitis pathogenesis
Co-supervisor
 Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - 2015 Modulation of microglia reactivity by S100B in Multiple Sclerosis
Co-supervisor
 Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2013 - 2014 Role of S100B on central nervous system demyelination and remyelination
Co-supervisor
 Biopharmaceutical Sciences (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019 - 2019 IV Symposium of the Portuguese Glial Network - organizing committee (2019/05/29 - 2019/05/29)
Symposium (Member of the Organising Committee)
 Universidade de Lisboa Faculdade de Farmácia, Portugal
2014/11/07 - 2014/11/08 Profiling alterations in microglia dynamic properties by neuroinflammation (2014/11/07 - 2014/11/08)
Workshop (Member of the Organising Committee)
 Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2012/02/06 - 2012/02/10 Implementation and characterization of nerve cell cultures (2012/02/06 - 2012/02/10)
Workshop (Member of the Organising Committee)
 Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2010/01/25 - 2010/01/29 Basic notions and implementation of nerve cell cultures (2010/01/25 - 2010/01/29)
Workshop (Member of the Organising Committee)
 Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
2009/02/19 - 2009/02/21 Update on the methodologies involved on inflammation assessment (2009/02/19 - 2009/02/21)
Workshop (Other)
 Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023 O papel da microglia no desenvolvimento da Esclerose Múltipla Rita Alexandra Andrade da Cruz Soares Ramos (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2023 Investigating the role of glial cell in an animal model of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay (ARSACS) Benjamim Pedro Fidalgo (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 Neuronal and behavioral alterations after intake of N-ethylpentylone in CD-1 mice
(Thesis) Arguer
 Catarina Isabel Venda Grilo (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 Role of Microbiome in Multiple Sclerosis
(Thesis) Main arguer
 Margarida Barrocas Fazendeiro (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021/11/16 Effects of chronic caffeine consumption on adipose tissue angiogenesis, hypoxia, and inflammation in metabolic diseases: characterization of adenosine receptors
(Thesis) Arguer
 Solange Marques Farreca (Master)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 Protective role of ACEA in a kainic acid-induced model of epilepsy: Synthetic cannabinoids as novel therapies for drug-resistant epilepsy
(Thesis) Main arguer
 Sara Bettencourt Melo Fonseca (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2021 Aging Associated Neuroinflammatory Changes Following EAE Induction Beatriz Lopes da Silva Fernandes (Other)
Universidade de Lisboa Faculdade de Farmácia, Portugal

Association member

Society Organization name Role
2013 - Current Sociedade Portuguesa de Neurociências

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2023/09 - Current Hematology (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2023/03 - Current Hematology II (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - Current Pathologic anatomy and molecular pathogenesis Ciências Farmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - Current Phisiopathology of neuroinflammation Ciências Biofarmacêuticas (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/02/18 - Current Histology and embriology Integrated master degree in Pharmaceutical Sciences (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2020 - Current Advances in Neuropharmaceutics (Curso de doutoramento (conclusão de unidades curriculares)) Universidade de Lisboa Faculdade de Farmácia, Portugal
2015 - Current Neurobiology Integrated master degree in Pharmaceutical Sciences (Mestrado integrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Current Development and Organization of the Nervous System Master in Biopharmaceutical Sciences (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Current Neuropathology and Neuropharmacology Master in Biopharmaceutical Sciences (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal
2014 - Current Pathophysiology of Neuroinflammation Master in Biopharmaceutical Sciences (Mestrado) Universidade de Lisboa Faculdade de Farmácia, Portugal

Journal scientific committee

Journal title (ISSN) Publisher
2020/12 - Current Frontiers in Cellular Neuroscience Frontiers Media SA
2020/02/17 - Current Frontiers in Pediatrics (2296-2360) Frontiers Media SA
2018 - 2018 Frontiers in Neuroscience (1662-453X) Frontiers Media SA
2018 - 2018 Advances in Medical Sciences (1898-4002) Elsevier
2018 - 2018 International Journal of Medical Sciences (1449-1907) Ivyspring International Publisher
2017 - 2017 Neurochemistry International (0197-0186) Elsevier
2014 - 2014 Neurotoxicity Research (1476-3524) Springer-Verlag
Distinctions

Other distinction

2019 Portuguese Neuroscience Society Scholarship
2017 Best Oral Communication at 4th International Porto Congress of Multiple Sclerosis
2015 Stipend for participation at the Training Scholl "Creating and phenotyping mouse models of disease and ageing"
2013 Du Pré grant
Multiple Sclerosis International Federation, United Kingdom