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Bruno Sepodes is a Pharmacist and Full Professor of Pharmacological Sciences, with additional interests and responsibilities in the domains of Pharmacoepidemiology and Regulatory Science, at the Faculty of Pharmacy of the Universidade de Lisboa (FFUL, Portugal). He is a Pharmacist (PharmD) by training, holding a MSc in Regulatory Science, a PhD in Pharmacology and Habilitation in Pharmacology and Pharmacotherapy, all by the University of Lisbon (Portugal). Bruno also holds a MPH degree from the Bloomberg School of Public Health of the Johns Hopkins University (USA), obtained in 2020. In addition to teaching Pharmacology, Pharmacotherapy and Regulatory Science at the Universidade de Lisboa, Bruno is the Vice-President of the School Council, a Member of the Scientific Council, Member of the Commission for the Promotion of Equality, Inclusion and Non-Discrimination, and President of the Ethics Committee for Research with Human Beings of FFUL. Bruno is Honorary Senior Lecturer in the Centre for Translational Medicine & Therapeutics within William Harvey Research Institute at the Queen Mary University of London (United Kindgom). As Senior Expert for INFARMED (the Portuguese National Authority for Medicines and Health Products), he became a member of the European Medicines Agency’s Committee for Orphan Medicinal Products (COMP) in 2008 and served for two mandates as Chairperson (2012-2018). Additionally, Bruno is also member of the European Medicines Agency’s Committee for Human Medicinal Products (CHMP) and of the Committee of Advanced Therapies (CAT). Since November 2018, Bruno is the Vice-Chair of the Committee of Human Medicinal Products (CHMP), with several other leadership roles at the European Medicines Agency, in activities related to the work of this committee. Additionally, Bruno represents the European Commission and the Regulatory Network at the Assembly of the International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). Since 2022, Bruno is the Co-Chair of the Emergency Task Force (ETF) at EMA, dealing both with public health emergencies and preparedness. In terms of awards and public recognition of his work, in 2018 Bruno received the “EURORDIS Leadership Black Pearl Award” on Rare Diseases, an award created by the EURORDIS Rare Disease Europe, and attributed to an individual who has demonstrated remarkable leadership in the field of rare diseases at a European level. Bruno received 15 national and international scientific awards and was on the top 100 inspirational industry professionals of “The Medicine Maker Power List 2018”, under the category ‘Masters of Change’ for year 2018. In 2021 Bruno was distinguished in Portugal with the award ‘Prémio Almofariz – Personality of the Year” given the active contributions to the regulatory and scientific discussions during the COVID-19 pandemic.
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Identification

Personal identification

Full name
Bruno Miguel Nogueira Sepodes

Citation names

  • Sepodes, Bruno
  • Bruno Sepodes
  • B. Sepodes
  • B.M.N. Sepodes

Author identifiers

Ciência ID
F312-4140-7A60
ORCID iD
0000-0002-2761-0955
Scopus Author Id
6507271629

Email addresses

  • bsepodes@ff.ulisboa.pt (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
French Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Education
Degree Classification
2020
Concluded
 Master of Public Health (MPH) (Master Universitario)
Johns Hopkins University Bloomberg School of Public Health, United States
2014
Concluded
 n/a (Título de Agregado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"n/a" (THESIS/DISSERTATION)
2008
Concluded
 Doutoramento em Farmácia (Doutoramento)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"Modulação Farmacológica da Lesão Induzida por Isquémia-Reperfusão Hepática" (THESIS/DISSERTATION)
2008
Concluded
 Farmácia (Doutoramento)
Major in Especialidade: Farmacologia
Universidade de Lisboa, Portugal
"Modulação Farmacológica da Lesão Induzida por Isquémia - Reperfusão Hepática" (THESIS/DISSERTATION)
2006
Concluded
 Mestrado em Regulação e Avaliação do Medicamento e Produtos de Saúde (Mestrado)
Universidade de Lisboa Faculdade de Farmácia, Portugal
""Contribuição para o desenvolvimento não-clínico do Tempol como novo fármaco anti-inflamatório"" (THESIS/DISSERTATION)
2001
Concluded
 Licenciatura em Ciências Farmacêuticas (Licenciatura)
Universidade de Lisboa Faculdade de Farmácia, Portugal
"n.a." (THESIS/DISSERTATION)
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2021/12/07 - Current Full Professor (University Teacher) Universidade de Lisboa, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2020/10/01 - 2021/12/06 Associate Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2008 - 2020 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2016 - 2019 Assistant Professor (University Teacher) Universidade de Lisboa, Portugal
2013 - 2016 Assistant Professor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2006 - 2008 Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2005 - 2006 Trainee Assistant (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal
2003 - 2005 Tutor (University Teacher) Universidade de Lisboa Faculdade de Farmácia, Portugal

Positions / Appointments

Category
Host institution 		Employer
2022 - Current Vice-President of the School Board Universidade de Lisboa Faculdade de Farmácia, Portugal
2022 - Current Membro do Conselho Científico Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2022 Membro do Conselho de Escola Universidade de Lisboa, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2019 - 2022 Conselho Pedagógico Universidade de Lisboa, Portugal
Universidade de Lisboa Faculdade de Farmácia, Portugal
2018 - 2019 Conselho geral ou orgão correspondente Universidade de Lisboa, Portugal
2017 - 2019 Conselho pedagógico Universidade de Lisboa, Portugal
2013 - 2016 Conselho pedagógico Universidade de Lisboa Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2022 - Current Co-Chair da Emergency Task Force (ETF) European Medicines Agency, Netherlands
2018/10 - Current Vice-Presidente (Vice-Chair) do Comité dos Medicamentos de Uso Humano (CHMP) European Medicines Agency, Netherlands
2013 - Current Membro do Comité de Terapias Avançadas (CAT) European Medicines Agency, Netherlands
2012 - Current Membro do Comité dos Medicamentos de Uso Humano (CHMP) European Medicines Agency, Netherlands
2018 - 2020 Membro do Comité dos Medicamentos Órfãos (COMP) European Medicines Agency, Netherlands
2012/09 - 2018/09 Presidente do Comité dos Medicamentos Órfãos (COMP) European Medicines Agency, Netherlands
2008 - 2012 Membro do Comité dos Medicamentos Órfãos (COMP) European Medicines Agency, Netherlands
Projects

Contract

Designation Funders
2023 - Current MORE EFFECTIVE AND ETHICAL USE OF REGISTRY DATA TO SUPPORT PATIENT- CENTERED REGULATORY AND HEALTH TECHNOLOGY ASSESSMENT DECISION-MAKING (MORE-EUROPA)
Project 101095479
Co-Principal Investigator (Co-PI)
Universidade de Lisboa Faculdade de Farmácia, Portugal
 European Commission
Ongoing
2019/01/01 - 2019/12/31 Instituto de Investigação do Medicamento
UID/DTP/04138/2019
Universidade de Lisboa Faculdade de Farmácia, Portugal

Universidade de Lisboa Instituto de Investigação do Medicamento, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013/06/01 - 2015/11/30 S-Glutationilação na Doença de Parkinson.
PTDC/NEU-OSD/0502/2012
 Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/08/31 Peptidos de interacção com a albumina para melhor a farmacocinética das proteinas
PTDC/SAU-FAR/115846/2009
Universidade de Lisboa Instituto Superior Técnico, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2013/12/31 Projecto Estratégico - UI 4013 - 2011-2012
PEst-OE/SAU/UI4013/2011
Universidade de Lisboa Faculdade de Farmácia, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Book
  1. Mateus, Vanessa; Sepodes, Bruno; Pinto, Rui Manuel Amaro. New Pharmacological Approaches in Crohn's Disease: Preclinical Study. Lambert Academic Publishing. 2019.
    Published
  2. Sepodes, Bruno. Prontuário Terapêutico 11. 2012.
  3. Sepodes, Bruno. Prontuário Terapêutico 10. 2011.
  4. Sepodes, Bruno. Prontuário Terapêutico 9. 2010.
  5. Sepodes, Bruno. Prontuário Terapêutico 8. Portugal. 2009.
Book chapter
  1. Drafi, F.; Ponist, S.; Sepodes, B.; Bauerova, K.. "Effects of Selected Non-biological and Biological Disease-Modifying Anti-rheumatic Drugs, and mRNA Vaccines on Mononuclear Phagocyte System". 321-341. 2022.
  2. Bettencourt-Câmara, Madalena; Sepodes, Bruno; Bronze, Rosário; Figueira, Maria-Eduardo. "Supplements in the EU: an updated analysis of health claims related to articular joint health". Book Publisher International, 2019.
    10.9734/EJNFS/2016/19031
  3. Câmara, Madalena Bettencourt da; Figueira, Maria Eduardo; Ferreira, João Pedro Borges; Coelho, Ana Varela; Feliciano, Rui; Silva, Andreia Bento da; Mecha, Elsa; et al. "Caracterização química e avaliação da actividade biológica da framboesa (Rubus Idaeus L.) : Contribuição para o desenvolvimento de uma alegação de saúde". 2019.
Conference paper
  1. Edite Teixeira de Lemos; Flávio Reis; Lina Carvalho; Natércia Teixeira; Alice Santos Silva; Georgina Correia da Silva; Petronila Rocha Pereira; et al. "O exercício físico como modulador positive dos factores de risco cardiovascular- acção cardiometabólica, antioxidante e anti-inflamatória.". 2008.
Conference poster
  1. Marques, Adriana; Torre, Carla; Pinto, Rui; Sepodes, Bruno; Rocha, Joao. Corresponding author: Marques, Adriana. "Treatment Advances in Sepsis and Septic Shock: Modulating pro- and anti-inflammatory mechanisms (A review)". Paper presented in Simpósio Científico "O Futuro Hoje: Novas Terapêuticas Moleculares e Biológicas” - Ordem dos Farmacêuticos, SRSRA, 2023.
  2. Marques, Adriana; Torre, Carla; Pinto, Rui; Rocha, Joao; Sepodes, Bruno. Corresponding author: Marques, Adriana. "Tumor Mutational Burden in Colorectal Cancer: Implications for Treatment". Paper presented in Simpósio Científico "O Futuro Hoje: Novas Terapêuticas Moleculares e Biológicas” - Ordem dos Farmacêuticos, SRSRA, 2023.
  3. Mateus, Vanessa; Rocha, João; Mota-Filipe, Hélder; Sepodes, Bruno; Pinto, Rui Manuel Amaro. "Erythropoietin as a new hope for Inflammatory Bowel Disease". Paper presented in 3rd Innovation Week - Conferência Anual das Redes Temáticas Interdisciplinares, 2017.
Journal article
  1. Stephanie Buchholz; Eugenia Di Meco; Ewa Z. Balkowiec-Iskra; Bruno Sepodes; Marco Cavaleri. "Generating clinical evidence for treatment and prevention options for long COVID". Nature Medicine (2024): https://doi.org/10.1038/s41591-024-03031-5.
    10.1038/s41591-024-03031-5
  2. Francesca Cerreta; Ewa Balkowiec Iskra; Amelia Cupelli; Bruno Sepodes; Elina Rönnemaa; Mário Miguel Rosa; Sabine Mayrhofer; et al. "Medicines for an aging population: The EMA perspective and policies". Journal of the American Geriatrics Society (2024): https://doi.org/10.1111/jgs.18953.
    10.1111/jgs.18953
  3. Bouwman, L.; Sepodes, B.; Leufkens, H.; Torre, C.. "Trends in orphan medicinal products approvals in the European Union between 2010–2022". Orphanet Journal of Rare Diseases 19 1 (2024): http://www.scopus.com/inward/record.url?eid=2-s2.0-85186179835&partnerID=MN8TOARS.
    10.1186/s13023-024-03095-z
  4. Frantisek Drafi; Katarina Bauerova; Martin Chrastina; Mohsen Taghdisiesfejír; João Rocha; Rosa Direito; Maria Eduardo Figueira; Bruno Sepodes; Silvester Ponist. "Rhodiola rosea L. Extract, a Known Adaptogen, Evaluated in Experimental Arthritis". Molecules (2023): https://doi.org/10.3390/molecules28135053.
    10.3390/molecules28135053
  5. Adriana Marques; Carla Torre; Rui Pinto; Bruno Sepodes; João Rocha. "Treatment Advances in Sepsis and Septic Shock: Modulating Pro- and Anti-Inflammatory Mechanisms". Journal of Clinical Medicine (2023): https://doi.org/10.3390/jcm12082892.
    10.3390/jcm12082892
  6. Joaquim Bié; Bruno Sepodes; Pedro C. B. Fernandes; Maria H. L. Ribeiro. "Polyphenols in Health and Disease: Gut Microbiota, Bioaccessibility, and Bioavailability". Compounds (2023): https://doi.org/10.3390/compounds3010005.
    10.3390/compounds3010005
  7. Inês Martinho; António Teixeira Rodrigues; José Guerreiro; João Rocha; Bruno Sepodes; Carla Torre. "A cross-country utilization patterns comparison of high expenditure therapeutic groups between Portugal and six European countries: the two sides of the Portuguese coin". Expert Review of Pharmacoeconomics & Outcomes Research (2023): https://doi.org/10.1080/14737167.2023.2144839.
    10.1080/14737167.2023.2144839
  8. Denkinger, M.; Knol, W.; Cherubini, A.; Simonds, A.; Lionis, C.; Lacombe, D.; Petelos, E.; et al. "Inclusion of functional measures and frailty in the development and evaluation of medicines for older adults". The Lancet Healthy Longevity 4 12 (2023): e724-e729. http://www.scopus.com/inward/record.url?eid=2-s2.0-85176733704&partnerID=MN8TOARS.
    10.1016/S2666-7568(23)00208-8
  9. Domingues, M.; Torre, C.; Guerreiro, J.P.; Barata, P.; Correia-Neves, M.; Rocha, J.; Sepodes, B.; Teixeira Rodrigues, A.. "COVID-19 pandemic and the quality of antibiotic use in primary care: an interrupted time-series study". International Journal for Quality in Health Care 35 2 (2023): http://www.scopus.com/inward/record.url?eid=2-s2.0-85160165752&partnerID=MN8TOARS.
    10.1093/intqhc/mzad014
  10. Joaquim Bié; Bruno Sepodes; Pedro C. B. Fernandes; Maria H. L. Ribeiro. "Enzyme Immobilization and Co-Immobilization: Main Framework, Advances and Some Applications". Processes (2022): https://doi.org/10.3390/pr10030494.
    10.3390/pr10030494
  11. Batista, Jorge; Torre, Carla; Sousa Lobo, José Manuel; Sepodes, Bruno. "A review of the continuous professional development system for pharmacists". Human Resources for Health 20 1 (2022): http://hdl.handle.net/10362/147862.
    https://doi.org/10.1186/s12960-021-00700-1
  12. Sepodes, B.; Mol, P.. "Editorial: Insights in Regulatory Science 2021". Frontiers in Medicine 9 (2022): http://www.scopus.com/inward/record.url?eid=2-s2.0-85139180491&partnerID=MN8TOARS.
    10.3389/fmed.2022.1033558
  13. Torre, Carla; Rodrigues, Antonio Teixeira; Domingues, Mariana; Guerreiro, Jose; Rocha, Joao; Sepodes, Bruno. "Does COVID-19 pandemic impacted on quality of antibiotic use in the community? An interrupted time-series analysis". Pharmacoepidemiology and Drug Safety (2022): https://publons.com/wos-op/publon/57446840/.
  14. Torre, Carla; Teixeira, Maria Manuel; Borges, Fabio Cardoso; Barao, Paula; Rocha, Joao; Sepodes, Bruno; Teixeira MM; et al. "A review of patient-reported outcomes for European medicines agency regulatory approval of oncologic drugs between 2017 and 2020". Pharmacoepidemiology and Drug Safety (2022): https://publons.com/wos-op/publon/57446844/.
    10.3389/fmed.2022.968272
  15. Rafael Amaral; Carla Torre; João Rocha; Bruno Sepodes. "Ebola outbreaks: A stress test of the preparedness of medicines regulatory systems for public health crises". Drug Discovery Today (2021): https://doi.org/10.1016/j.drudis.2021.06.019.
    10.1016/j.drudis.2021.06.019
  16. Rosa Direito; João Rocha; Bruno Sepodes; Maria Eduardo-Figueira. "From Diospyros kaki L. (Persimmon) Phytochemical Profile and Health Impact to New Product Perspectives and Waste Valorization". Nutrients (2021): https://doi.org/10.3390/nu13093283.
    10.3390/nu13093283
  17. Sepodes B; Rocha J; Batista J; Figueira ME; Dráfi F; Torre C. "Implementation and Access to Pre-exposure Prophylaxis for Human Immunodeficiency Virus by Men Who Have Sex With Men in Europe.". Frontiers in medicine (2021): http://europepmc.org/abstract/med/34513883.
    10.3389/fmed.2021.722247
  18. "Improvement of wheat cookies’ nutritional quality, by partial substitution with common bean and maize flours, sustained human glycemia and enhanced satiety perception". Cereal Chemistry (2021): http://dx.doi.org/10.1002/cche.10460.
    10.1002/cche.10460
  19. Rosa Direito; João Rocha; Bruno Sepodes; Maria Eduardo-Figueira. "Phenolic Compounds Impact on Rheumatoid Arthritis, Inflammatory Bowel Disease and Microbiota Modulation". Pharmaceutics 13 2 (2021): 145-145. https://doi.org/10.3390/pharmaceutics13020145.
    10.3390/pharmaceutics13020145
  20. Bártolo I; Santos BS; Fontinha D; Machado M; Francisco D; Sepodes B; Rocha J; et al. "Spiro-ß-lactam BSS-730A Displays Potent Activity against HIV and Plasmodium.". ACS infectious diseases (2021): http://europepmc.org/abstract/med/33395253.
    10.1021/acsinfecdis.0c00768
  21. Grácio, Madalena; Rocha, João; Pinto, Rui; Ferreira, Ricardo Boavida; Solas, João; Eduardo-Figueira, Maria; Sepodes, Bruno; Ribeiro, Ana Cristina; Boavida Ferreira, Ricardo. "A proposed lectin-mediated mechanism to explain the in vivo antihyperglycemic activity of ¿-conglutin from Lupinus albus seeds". (2021): http://hdl.handle.net/10400.5/23789.
    https://doi.org/10.1002/fsn3.2520
  22. Mota, Joana; Direito, Rosa; Rocha, João; Fernandes, João; Sepodes, Bruno; Figueira, Maria Eduardo; Raymundo, Anabela; et al. "Lupinus albus protein componentes inhibit MMP-2 and MMP-9 gelatinolytic activity in vitro and in vivo". International Journal of Molecular Sciences (2021): http://hdl.handle.net/10400.5/22755.
    10.3390/ijms222413286
  23. Viana, Paula; Meisel, Leonor; Lopes, Ana; de Jesus, Rosário; Sarmento, Georgina; Duarte, Sofia; Sepodes, Bruno; et al. "Identification of Antibiotics in Surface-Groundwater. A Tool towards the Ecopharmacovigilance Approach: A Portuguese Case-Study". Antibiotics 10 8 (2021): 888-888. http://hdl.handle.net/10316/103678.
    https://doi.org/10.3390/antibiotics10080888
  24. Sepodes, Bruno. "The translational value of animal models in orphan medicines designations for rare paediatric neurological diseases". Regulatory Toxicology and Pharmacology 118 (2020): 104810-104810. http://dx.doi.org/10.1016/j.yrtph.2020.104810.
    10.1016/j.yrtph.2020.104810
  25. Sepodes, Bruno; Carvalho, Marta; Sepodes, Bruno; Martins, Ana Paula. "Patient access to gene therapy medicinal products: a comprehensive review". BMJ Innovations (2020): bmjinnov--2020--0004-bmjinnov--2020--0004. http://dx.doi.org/10.1136/bmjinnov-2020-000425.
    10.1136/bmjinnov-2020-000425
  26. Segundo Mariz; Kerstin Westermark; Bruno Sepodes. "Designation of orphan conditions in Europe: regulatory observations and considerations after implementation of regulation 141/2000". Expert Opinion on Orphan Drugs (2020): 1-7. https://doi.org/10.1080/21678707.2020.1784720.
    10.1080/21678707.2020.1784720
  27. Eichler HG; Cavaleri M; Enzmann H; Scotti F; Sepodes B; Sweeney F; Vamvakas S; Rasi G. "Clinical trials for Covid-19: can we better use the short window of opportunity?". Clinical pharmacology and therapeutics (2020): http://europepmc.org/abstract/med/32407539.
    10.1002/cpt.1891
  28. Rocha, João; Leandro, Raquel; Direito, Rosa; Gonçalves, Margarida; Duarte, Maria Paula; Fernandes, Adelaide; Sepodes, Bruno; et al. "Attenuation of colonic injury and inflammation by administration of a phenolic extract of summer savory (Satureja hortensis l.) in experimental inflammatory bowel disease in mice". Applied Sciences 10 23 (2020): 8465-8465. http://hdl.handle.net/10362/114530.
    https://doi.org/10.3390/app10238465
  29. Sheean ME; Malikova E; Duarte D; Capovilla G; Fregonese L; Hofer M; Magrelli A; et al. "Nonclinical data supporting orphan medicinal product designations in the area of rare infectious diseases.". Drug discovery today (2019): http://europepmc.org/abstract/med/31704277.
    10.1016/j.drudis.2019.10.015
  30. Sepodes, Bruno. "Are Novel, Nonrandomized Analytic Methods Fit for Decision Making? The Need for Prospective, Controlled, and Transparent Validation.". Clinical pharmacology and therapeutics (2019): https://doi.org/10.1002/cpt.1638.
    10.1002/cpt.1638
  31. Rosa Direito; João Rocha; Ana-Teresa Serra; Adelaide Fernandes; Marisa Freitas; Eduarda Fernandes; Rui Pinto; et al. "Anti-inflammatory Effects of Persimmon (Diospyros kaki L.) in Experimental Rodent Rheumatoid Arthritis". Journal of Dietary Supplements (2019): https://doi.org/10.1080/19390211.2019.1645256.
    10.1080/19390211.2019.1645256
  32. Rosa Direito; Catarina Reis; Luís Roque; Margarida Gonçalves; Ana Sanches-Silva; Maria Manuela Gaspar; Rui Pinto; et al. "Phytosomes with Persimmon (Diospyros kaki L.) Extract: Preparation and Preliminary Demonstration of In Vivo Tolerability". Pharmaceutics (2019): https://doi.org/10.3390/pharmaceutics11060296.
    10.3390/pharmaceutics11060296
  33. João Rocha; Ana Lima; Maria Margarida Gonçalves; Maria Paula Duarte; Vanessa Mateus; Catarina Sousa; Adelaide Fernandes; et al. "Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice". Medicines (2019): https://www.mdpi.com/2305-6320/6/2/65.
    10.3390/medicines6020065
  34. Borg, J.-J.; Melchiorri, D.; Sepodes, B.; Caramella, C.M.; Tomino, C.; Micallef, B.; Serracino-Inglott, A.; Nistico, R.. "Optimising bench science to withstand regulatory scrutiny". Pharmacological Research 139 (2019): 491-493. http://www.scopus.com/inward/record.url?eid=2-s2.0-85055581024&partnerID=MN8TOARS.
    10.1016/j.phrs.2018.10.014
  35. O’Connor, D.J.; Sheean, M.E.; Hofer, M.P.; Tsigkos, S.; Mariz, S.; Fregonese, L.; Larsson, K.; et al. "Defining orphan conditions in the context of the European orphan regulation: challenges and evolution". Nature Reviews Drug Discovery (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85063584936&partnerID=MN8TOARS.
    10.1038/nrd.2018.128
  36. Carvalho, M.; Martins, A.P.; Sepodes, B.. "Hurdles in gene therapy regulatory approval: a retrospective analysis of European Marketing Authorization Applications". Drug Discovery Today 24 3 (2019): 823-828. http://www.scopus.com/inward/record.url?eid=2-s2.0-85059141441&partnerID=MN8TOARS.
    10.1016/j.drudis.2018.12.007
  37. Mendes, C.; Rocha, J.; Direito, R.; Fernandes, A.; Sepodes, B.; Figueira, M.-E.; Ribeiro, M.H.. "Anti-inflammatory activity of grapefruit juice in an in vivo model of ulcerative colitis: Comparability studies of unprocessed and bioprocessed juices". Journal of Functional Foods 63 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85072299230&partnerID=MN8TOARS.
    10.1016/j.jff.2019.103564
  38. Rocha, J.; Direito, R.; Lima, A.; Mota, J.; Gonçalves, M.; Duarte, M.P.; Solas, J.; et al. "Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice". Biomedicine and Pharmacotherapy 118 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85070874907&partnerID=MN8TOARS.
    10.1016/j.biopha.2019.109351
  39. Direito, Rosa; Rocha, João; Lima, Ana; Gonçalves, Maria Margarida Boavida Pontes; Duarte, Maria Paula Amaro de Castilho; Mateus, Vanessa; Sousa, Catarina; et al. "Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in Experimental Bowel Disease in Mice". (2019): http://hdl.handle.net/10362/97775.
    https://doi.org/10.3390/medicines6020065
  40. Rocha, João; Direito, Rosa; Lima, Ana; Mota, Joana; Gonçalves, Margarida; Duarte, Maria Paula; Solas, João; et al. "Reduction of inflammation and colon injury by a Pennyroyal phenolic extract in experimental inflammatory bowel disease in mice". (2019): http://hdl.handle.net/10400.5/18269.
    https://doi.org/10.1016/j.biopha.2019.109351
  41. Direito, Rosa; Reis, Catarina; Roque, Luís; Gonçalves, Margarida; Sanches-Silva, Ana; Gaspar, Maria Manuela; Pinto, Rui; et al. "Phytosomes with persimmon (Diospyros kaki l.) extract". (2019): http://hdl.handle.net/10362/146961.
    https://doi.org/10.3390/pharmaceutics11060296
  42. Sepodes, Bruno. "The Challenges of the European Medicines Evaluation by 2025". (2019): https://doi.org/10.25756/rpf.v11i2-3.220.
    https://doi.org/10.25756/rpf.v11i2-3.220
  43. Andrea Ecker; Segundo Mariz; Frauke Naumann-Winter; Koenraad Norga; Ingeborg Barisic; Thomas Girard; Paolo Tomasi; Dirk Mentzer; Bruno Sepodes. "Comparative analysis of the scope of European Union paediatric investigation plans with corresponding orphan designations". Archives of Disease in Childhood 103 5 (2018): 427-430. https://doi.org/10.1136/archdischild-2017-313352.
    10.1136/archdischild-2017-313352
  44. Mateus, V.; Rocha, J.; Mota-Filipe, H.; Sepodes, B.; Pinto, R.. "Hemin reduces inflammation associated with TNBS-induced colitis". Clinical and Experimental Gastroenterology 11 (2018): 325-334. http://www.scopus.com/inward/record.url?eid=2-s2.0-85057986901&partnerID=MN8TOARS.
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  45. Vieira da Silva, S.A.; Clemente, A.; Rocha, J.; Direito, R.; Marques, H.C.; Sepodes, B.; Figueira, M.-E.; Ribeiro, M.H.. "Anti-inflammatory effect of limonin from cyclodextrin (un)processed orange juices in in vivo acute inflammation and chronic rheumatoid arthritis models". Journal of Functional Foods 49 (2018): 146-153. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051776212&partnerID=MN8TOARS.
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  46. Sepodes, Bruno. "Thiadiazolidinone-8 Ameliorates Inflammation Associated with Experimental Colitis in Mice.". Pharmacology (2018): http://europepmc.org/abstract/med/28965119.
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  47. Mateus, Vanessa; Rocha, João; Alves, Paula; Mota-Filipe, Hélder; Sepodes, Bruno; Pinto, Rui. "Thiadiazolidinone-8 ameliorates inflammation associated with experimental colitis in mice". (2018): http://hdl.handle.net/10400.21/7898.
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  48. Mateus, Vanessa; Rocha, João; Mota-Filipe, Helder; Sepodes, Bruno; Pinto, Rui. "Hemin reduces inflammation associated with TNBS-induced colitis". (2018): http://hdl.handle.net/10400.21/9220.
    10.2147/CEG.S166197
  49. Benedetta Polsinelli; Stelios Tsigkos; Frauke Naumann-Winter; Segundo Mariz; Bruno Sepodes. "Evolving prevalence of haematological malignancies in orphan designation procedures in the European Union". Orphanet Journal of Rare Diseases 12 1 (2017): https://doi.org/10.1186%2Fs13023-017-0567-7.
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  50. Sepodes, Bruno. "Demonstrating significant benefit of orphan medicines: analysis of 15 years of experience in Europe.". Drug discovery today (2017): http://europepmc.org/abstract/med/29024805.
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  51. Sepodes, Bruno. "Development of Exon Skipping Therapies for Duchenne Muscular Dystrophy: A Critical Review and a Perspective on the Outstanding Issues.". Nucleic acid therapeutics (2017): http://europepmc.org/abstract/med/28796573.
    10.1089/nat.2017.0682
  52. Sepodes, Bruno. "Dyospiros kaki phenolics inhibit colitis and colon cancer cell proliferation, but not gelatinase activities.". The Journal of nutritional biochemistry (2017): http://europepmc.org/abstract/med/28494341.
    10.1016/j.jnutbio.2017.03.002
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    10.1016/j.drudis.2017.06.003
  54. Sepodes, Bruno. "Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework.". Frontiers in medicine (2017): http://europepmc.org/abstract/med/29124055.
    10.3389/fmed.2017.00182
  55. Sepodes, Bruno. "Advanced Therapy Medicinal Products for Rare Diseases: State of Play of Incentives Supporting Development in Europe.". Frontiers in medicine (2017): http://europepmc.org/abstract/med/28560211.
    10.3389/fmed.2017.00053
  56. Mateus, Vanessa; Rocha, João; Alves, Paula; Mota-Filipe, Helder; Sepodes, Bruno; Pinto, Rui Manuel Amaro. "Anti-inflammatory effect of erythropoietin in the TNBS-induced colitis". (2017): http://hdl.handle.net/10400.21/6659.
    10.1111/bcpt.12663
  57. Sepodes B. "Regulation Of Orphan Medicinal Products In Europe: History Trends And Challenges.". (2016): http://europepmc.org/abstract/med/27673673.
    10.1016/j.clinthera.2016.07.101
  58. Figueira ME; Oliveira M; Direito R; Rocha J; Alves P; Serra AT; Duarte C; et al. "Protective effects of a blueberry extract in acute inflammation and collagen-induced arthritis in the rat.". Biomedicine & Pharmacotherapy 83 (2016): 1191-1202. http://europepmc.org/abstract/med/27551767.
    10.1016/j.biopha.2016.08.040
  59. Mateus V; Rocha J; Alves P; Mota-Filipe H; Sepodes B; Pinto RM. "Anti-Inflammatory Effect of Erythropoietin in the TNBS-induced Colitis.". (2016): http://europepmc.org/abstract/med/27579991.
    10.1111/bcpt.12663
  60. Sousa M; Machado V; Costa R; Figueira ME; Sepodes B; Barata P; Ribeiro L; Soares R. "Red Raspberry Phenols Inhibit Angiogenesis: A Morphological and Subcellular Analysis Upon Human Endothelial Cells.". (2016): http://europepmc.org/abstract/med/26590362.
    10.1002/jcb.25452
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  62. Morel T; Lhoir A; Picavet E; Mariz S; Sepodes B; Llinares J; Cassiman D. "Regulatory watch: The orphan drug pipeline in Europe.". (2016): http://europepmc.org/abstract/med/27245390.
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  63. Straub, Volker; Balabanov, Pavel; Bushby, Kate; Ensini, Monica; Goemans, Nathalie; De Luca, Annamaria; Pereda, Alejandra; et al. "Stakeholder cooperation to overcome challenges in orphan medicine development: the example of Duchenne muscular dystrophy". Lancet Neurology 15 8 (2016): 882-890. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000377545800024&KeyUID=WOS:000377545800024.
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  64. Bettencourt-Câmara, Madalena; Sepodes, Bruno; Bronze, Rosário; Figueira, Maria-Eduardo. "Supplements in the European Union: an analysis of health claims related to articular joint health". (2016): http://hdl.handle.net/10400.26/9918.
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  65. Cardoso FL; Herz J; Fernandes A; Rocha J; Sepodes B; Brito MA; McGavern DB; Brites D. "Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects.". (2015): http://europepmc.org/abstract/med/25924675.
    10.1186/s12974-015-0299-3
  66. Tsigkos S; Mariz S; Llinares J; Fregonese L; Aarum S; Naumann-Winter F; Westermark K; Sepodes B. "Erratum to: Establishing medical plausibility in the context of orphan medicines designation in the European Union.". (2015): http://europepmc.org/abstract/med/26444545.
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  67. Rocha, J.; Figueira, M.-E.; Barateiro, A.; Fernandes, A.; Brites, D.; Pinto, R.; Freitas, M.; et al. "Inhibition of glycogen synthase kinase-3ß attenuates organ injury and dysfunction associated with liver ischemia-reperfusion and thermal injury in the rat". Shock 43 4 (2015): 369-378. http://www.scopus.com/inward/record.url?eid=2-s2.0-84924905290&partnerID=MN8TOARS.
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  68. Rocha J; Figueira ME; Barateiro A; Fernandes A; Brites D; Pinto R; Freitas M; et al. "Inhibition of Glycogen Synthase Kinase 3ß (GSK-3ß) Attenuates Organ Injury and Dysfunction Associated to Liver Ischemia-Reperfusion and Thermal Injury in the Rat.". (2014): http://europepmc.org/abstract/med/25394244.
  69. Segundo Mariz; Stelios Tsigkos; Laura Fregonese; Stiina Aarum; Eleonora Dehlink; Jordi Llinares; Bruno Sepodes. "The orphan framework as a new opportunity: an expert opinion". Expert Opinion on Orphan Drugs 2 11 (2014): 1181-1186. http://dx.doi.org/10.1517/21678707.2014.973849.
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  70. Figueira ME; Câmara MB; Direito R; Rocha J; Serra AT; Duarte CM; Fernandes A; et al. "Chemical characterization of a red raspberry fruit extract and evaluation of its pharmacological effects in experimental models of acute inflammation and collagen-induced arthritis.". (2014): http://europepmc.org/abstract/med/25322288.
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  71. Rocha J; Eduardo-Figueira M; Barateiro A; Fernandes A; Brites D; Bronze R; Duarte C; et al. "Anti-Inflammatory Effect of Rosmarinic Acid and an Extract of Rosmarinus officinalis in Rat Models of Local and Systemic Inflammation.". (2014): http://europepmc.org/abstract/med/25287116.
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  72. Rocha J; Eduardo-Figueira M; Barateiro A; Fernandes A; Brites D; Pinto R; Freitas M; et al. "Erythropoietin Reduces Acute Lung Injury and Multiple Organ Failure/Dysfunction Associated to a Scald-Burn Inflammatory Injury in the Rat.". (2014): http://europepmc.org/abstract/med/25270658.
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  73. Bernardo Oliveira Ratilal; Mariana Moreira Coutinho Arroja; Joao Pedro Fidalgo Rocha; Adelaide Maria Afonso Fernandes; Andreia Pereira Barateiro; Dora Maria Tuna Oliveira Brites; Rui Manuel Amaro Pinto; et al. "Neuroprotective effects of erythropoietin pretreatment in a rodent model of transient middle cerebral artery occlusion". Journal of Neurosurgery 121 1 (2014): 55-62. http://dx.doi.org/10.3171/2014.2.jns132197.
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  74. Márcia Reto; Cristina Almeida; João Rocha; Bruno Sepodes; Maria-Eduardo Figueira. "Green Tea (<i>Camellia sinensis</i>): Hypocholesterolemic Effects in Humans and Anti-Inflammatory Effects in Animals". FNS 05 22 (2014): 2185-2194. http://dx.doi.org/10.4236/fns.2014.522231.
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  75. Stelios Tsigkos; Segundo Mariz; Jordi Llinares; Laura Fregonese; Stiina Aarum; Naumann-Winter Frauke; Kerstin Westermark; Bruno Sepodes. "Establishing medical plausibility in the context of orphan medicines designation in the European Union". Orphanet Journal of Rare Diseases 9 1 (2014): 175-175. http://dx.doi.org/10.1186/s13023-014-0175-8.
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  76. Joao Rocha; Maria-Eduardo Figueira; Andreia Barateiro; Adelaide Fernandes; Dora Brites; Rui Pinto; Marisa Freitas; et al. "Inhibition of Glycogen Synthase Kinase 3ß (GSK-3ß) Attenuates Organ Injury and Dysfunction Associated to Liver Ischemia-Reperfusion and Thermal Injury in the Rat". Shock (2014): 1-1. http://dx.doi.org/10.1097/shk.0000000000000298.
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  77. Ratilal, B.O.; Rocha, J.P.F.; Fernandes, A.M.A.; Arroja, M.M.C.; Barateiro, A.P.; Brites, D.M.T.O.; Pinto, R.M.A.; Sepodes, B.M.N.; Mota-Filipe, H.D.. "TDZD-8 pre-treatment in transient middle cerebral artery occlusion". Biomedicine and Aging Pathology 4 4 (2014): 361-367. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908333539&partnerID=MN8TOARS.
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  78. Tsigkos, S.; Llinares, J.; Mariz, S.; Aarum, S.; Fregonese, L.; Dembowska-Baginska, B.; Elbers, R.; et al. "Use of biomarkers in the context of orphan medicines designation in the European Union". Orphanet Journal of Rare Diseases 9 1 (2014): http://www.scopus.com/inward/record.url?eid=2-s2.0-84893226672&partnerID=MN8TOARS.
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  79. S. Silva; B. Sepodes; J. Rocha; R. Direito; A. Fernandes; D. Brites; M. Freitas; et al. "Protective effects of hydroxytyrosol-supplemented refined olive oil in animal models of acute inflammation and rheumatoid arthritis". The Journal of Nutritional Biochemistry (2014): http://dx.doi.org/10.1016/j.jnutbio.2014.11.011.
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  80. Vaquer, Guillaume; Riviere, Frida; Mavris, Maria; Bignami, Fabrizia; Llinares-Garcia, Jordi; Westermark, Kerstin; Sepodes, Bruno. "Animal models for metabolic, neuromuscular and ophthalmological rare diseases". Nature Reviews Drug Discovery 12 4 (2013): 287-305.
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  81. Mateus, V.; Escola Superior de Tecnologia da Saúde de Lisboa - IPL - Pharmacology and Translational Research Group, iMED; Faísca, P.; Departamento de Anatomia Patologica, Faculdade de Medicina Veterinária - ULHT. Portugal; Mota-Filipe, H.; Pharmacology and Translational Research Group, iMED – Faculdade de Farmácia. Universidade de Lisboa. Po; Sepodes, Bruno M.; Pharmacology and Translational Research Group, iMED – Faculdade de Farmácia. Universidade de Lisboa. ; Pinto, R.; Pharmacology and Translational Research Group, iMED – Faculdade de Farmácia. Universidade de Lisboa. Portugal; Mateus, V.; Faísca, P.; et al. "Development of TNBS-induced colitis: animal model to test new pharmacological approaches". (2013): http://www.actafarmaceuticaportuguesa.com/index.php/afp/article/view/4.
  82. Sequeira Silva, Ângela; Rosa, Bruno; Soares, João; Sepodes, Bruno. "CHALLENGES AND OPPORTUNITIES IN APPROACH THERAPY OF RHEUMATOID ARTHRITIS". (2013): https://doi.org/10.25756/rpf.v5i2.52.
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  83. Serra, Ana Teresa; Rocha, J.; Sepodes, B.; Matias, Ana A.; Feliciano, Rodrigo P.; de Carvalho, Agostinho; Bronze, Maria R.; Duarte, Catarina M. M.; Figueira, M. E.. "Evaluation of cardiovascular protective effect of different apple varieties - Correlation of response with composition". Food Chemistry 135 4 (2012): 2378-2386.
    10.1016/j.foodchem.2012.07.067
  84. Ferreira, Paula; Repolho, Marta; Ribeiro, Maria Joana; Sepodes, Bruno. "DIAGNOSIS AND THERAPEUTIC APPROACH OF OSTEOARTHRITIS". (2012): http://revista.farmacoterapia.pt/index.php/rpf/article/view/75.
    10.25756/rpf.v4i1.75
  85. Sepodes, Bruno; Pharmacology & Translational Research, Faculdade de Farmácia da Universidade de Lisboa. Portugal Preside; Mota-Filipe, Helder; Pharmacology & Translational Research, Faculdade de Farmácia da Universidade de Lisboa. Portugal Pr; Sepodes, Bruno; Pharmacology & Translational Research, Faculdade de Farmácia da Universidade de Lisboa. Portugal Preside; Mota-Filipe, Helder; Pharmacology & Translational Research, Faculdade de Farmácia da Universidade de Lisboa. Portugal Pr. "Doenças Raras e Medicamentos Órfãos". (2012): http://www.actafarmaceuticaportuguesa.com/index.php/afp/article/view/16.
  86. Faia, Tânia; Morais, Sílvia; Rosa, Andreia; Santos, Joana; Sepodes, Bruno. "A MULTIDIMENSIONAL PERSPECTIVE THE IN MIGRAINE TREATMENT". (2012): https://doi.org/10.25756/rpf.v4i3.67.
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  87. Westermark K; Holm BB; Söderholm M; Llinares-Garcia J; Rivière F; Aarum S; Butlen-Ducuing F; et al. "European regulation on orphan medicinal products: 10 years of experience and future perspectives.". (2011): http://europepmc.org/abstract/med/21532564.
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  88. Kapoor, A.; Shintani, Y.; Collino, M.; Osuchowski, M. F.; Busch, D.; Patel, N. S. A.; Sepodes, B.; et al. "BENEFICIAL ROLE OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-BETA/DELTA IN SEPTIC SHOCK". Shock 36 (2011): 20-20. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000294389500056&KeyUID=WOS:000294389500056.
  89. Maio, R.; Sepodes, B.; Thiemermann, C.; Mota-Filipe, H.. "OPPORTUNITIES TO ENHANCE ORGAN VIABILITY". Shock 36 (2011): 3-3. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000294389500003&KeyUID=WOS:000294389500003.
  90. Rocha, J.; Sepodes, B.; Pinto, R.; Raposo, J.; Borga, P.; Ferreira, C.; Mota-Filipe, H.. "PRE-TREATMENT WITH ERYTHROPOIETIN REDUCES ORGAN FAILURE IN A RAT MODEL OF THERMAL INJURY". Shock 36 (2011): 29-29. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000294389500088&KeyUID=WOS:000294389500088.
  91. da Silva, G.; Tanica, M.; Rocha, J.; Serrano, R.; Gomes, E. T.; Sepodes, B.; Silva, O.. "In vivo anti-inflammatory effect and toxicological screening of Maytenus heterophylla and Maytenus senegalensis extracts". Human & Experimental Toxicology 30 7 (2011): 693-700.
    10.1177/0960327110379242
  92. Brachkova, M. I.; Marques, P.; Rocha, J.; Sepodes, B.; Duarte, M. A.; Pinto, J. F.. "Alginate films containing Lactobacillus plantarum as wound dressing for prevention of burn infection". Journal of Hospital Infection 79 4 (2011): 375-377.
    10.1016/j.jhin.2011.09.003
  93. Maio, Rui; Sepodes, Bruno; Patel, Nimesh S. A.; Thiemermann, Christoph; Mota-Filipe, Helder; Costa, Paulo. "ERYTHROPOIETIN PRESERVES THE INTEGRITY AND QUALITY OF ORGANS FOR TRANSPLANTATION AFTER CARDIAC DEATH". Shock 35 2 (2011): 126-133.
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  94. Rauter, A.P.; Martins, A.; Borges, C.; Mota-Filipe, H.; Pinto, R.; Sepodes, B.; Justino, J.. "Erratum: Antihyperglycaemic and protective effects of flavonoids on streptozotocin-induced diabetic rats (Phytotherapy Research (2010) 24, Supplement 2 DOI: 10.1002/ptr.3017)". Phytotherapy Research 24 SUPPL. 2 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77953906546&partnerID=MN8TOARS.
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  95. Eduardo-Figueira, M.; Rocha, J.; Silva, A. L.; Bronze, M. R.; Mota-Filipe, H.; Sepodes, B.. "Characterization of the anti-hypercholesterolemic effect of traditional and exotic apple varieties from Portugal". Diabetes Obesity & Metabolism 12 (2010): 67-68. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000282373600106&KeyUID=WOS:000282373600106.
  96. Rauter, Amelia P.; Martins, Alice; Borges, Carlos; Mota-Filipe, Helder; Pinto, Rui; Sepodes, Bruno; Justino, Jorge. "Antihyperglycaemic and Protective Effects of Flavonoids on Streptozotocin-Induced Diabetic Rats". Phytotherapy Research 24 (2010): S133-S138.
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  97. Silva, A. L.; Rocha, J.; Mota-Filipe, H.; Sepodes, B.; Eduardo-Figueira, M.. "Evaluation of the anti-inflammatory effect of coffee and its polyphenols on a local inflammation model in rats". Diabetes Obesity & Metabolism 12 (2010): 61-61. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000282373600090&KeyUID=WOS:000282373600090.
  98. Roubaud, J.; Rocha, J.; Sepodes, B.; Eduardo-Figueira, M.. "Protective effect of kiwifruit in local model of inflammation in the rat". Diabetes Obesity & Metabolism 12 (2010): 60-60. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000282373600088&KeyUID=WOS:000282373600088.
  99. Rocha, J.; Eduardo-Figueira, M.; Bronze, M. R.; Sepodes, B.; Mota-Filipe, H.. "Protective effect of rosmarinic acid in local and systemic models of inflammation in the rat". Diabetes Obesity & Metabolism 12 (2010): 59-59. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000282373600087&KeyUID=WOS:000282373600087.
  100. Kapoor, Amar; Shintani, Yasunori; Collino, Massimo; Bailey, Lucy; Patel, Nimesh; Sepodes, Bruno. "Protective role of PPAR-beta/delta in cardiac dysfunction and organ injury/inflammation caused by endotoxemia in mice". Inflammation Research 59 (2010): S20-S20. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000275660100032&KeyUID=WOS:000275660100032.
  101. Rocha, Joao; Figueira, Maria Eduardo; Marques, Patricia; Lima, Beatriz Silva; Sepodes, Bruno; Filipe, Helder Mota. "Rosmarinic acid attenuates inflammatory-induced organ injury in thermal injury and liver ischemia-reperfusion-injury". Inflammation Research 59 (2010): S19-S19. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000275660100030&KeyUID=WOS:000275660100030.
  102. Kapoor, A.; Shintani, Y.; Collino, M.; Bailey, L. K.; Patel, N. S. A.; Sepodes, B.; Tripatara, P.; et al. "027 Protective role of peroxisome proliferator-activated receptor I/I' in cardiac dysfunction and organ injury/inflammation caused by endotoxin in mice". Heart 96 4 (2010): e8-e8. http://dx.doi.org/10.1136/hrt.2009.191064o.
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  103. Kapoor, Amar; Shintani, Yasunori; Collino, Massimo; Osuchowski, Marcin F.; Busch, Daniel; Patel, Nimesh S. A.; Sepodes, Bruno; et al. "Protective Role of Peroxisome Proliferator-activated Receptor-beta/delta in Septic Shock". American Journal of Respiratory and Critical Care Medicine 182 12 (2010): 1506-1515.
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  104. Milsom, A. B.; Patel, N. S. A.; Mazzon, E.; Tripatara, P.; Storey, A.; Mota-Filipe, H.; Sepodes, B.; et al. "Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice". Nitric Oxide-Biology and Chemistry 22 2 (2010): 141-148.
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  105. Patel, Nimesh S. A.; Brines, Michael; Sepodes, Bruno; Brown, Paul A. J.; Stewart, Keith N.; Mota-Filipe, Helder; Cerami, Anthony; Thiemermann, Christoph. "A TISSUE PROTECTIVE, BUT NON-HAEMATOPOIETIC, ANALOGUE OF ERYTHROPOIETIN FOR THE TREATMENT OF ACUTE KIDNEY INJURY". Shock 32 (2009): 5-5. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000269226200018&KeyUID=WOS:000269226200018.
  106. Rocha, Joao Pedro; Sepodes, Bruno Miguel; Eduardo-Figueira, Maria; Bronze, Rosario; Duarte, Catarina; Serra, Teresa; Silva-Lima, Beatriz; Mota-Filipe, Helder. "Anti-inflammatory effect of Rosmarinic acid on a model of carrageenan-induced paw edema". Faseb Journal 23 (2009): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000208621505443&KeyUID=WOS:000208621505443.
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  168. Pinto, R.; Carvalho, R.; Sepodes, B.; Barrento, C.; Mota-Filipe, H.; Silva-Lima, B.. "Involvement of nitric oxide synthase pathway and alpha 1-adrenoceptors in the noradrenaline-release induced by phenylephrine in the rat vas deferens". Fundamental & Clinical Pharmacology 18 (2004): 69-69. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000208663600379&KeyUID=WOS:000208663600379.
  169. Sepodes, B.; Pinto, R.; McDonald, M.; Thiemermann, C.; Mota-Filipe, H.. "The effect of haemoglobin pretreatment on the liver ischaemia/reperfusion injury". Fundamental & Clinical Pharmacology 18 (2004): 124-124. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000208663600704&KeyUID=WOS:000208663600704.
  170. Mota-Filipe H; Sepodes B; McDonald MC; Cuzzocrea S; Pinto R; Thiemermann C. "The novel PARP inhibitor 5-aminoisoquinolinone reduces the liver injury caused by ischemia and reperfusion in the rat.". (2002): http://europepmc.org/abstract/med/12444369.
  171. Sepodes, B.; McDonald, M. C.; Pinto, R.; Maio, R.; Caneira-da-Silva, M.; Mota-Filipe, H.; Thiemermann, C.. "THE EFFECT OF 5-AIQ ON THE LIVER ISCHAEMIA/REPERFUSION INJURY". Shock 18 Supplement (2002): 23-23. http://dx.doi.org/10.1097/00024382-200209001-00062.
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  172. Sepodes, B; Pinto, R; McDonald, MC; Mota-Filipe, H; Thiemermann, C. "Dithiocarbamates attenuate the organ injury and dysfunction caused by endotoxin in the rat". British Journal of Pharmacology 135 (2002): http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000174345200072&KeyUID=WOS:000174345200072.
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  174. Mota-Filipe, H.; Sepodes, B.; Pinto, R.; McDonald, M. C.; Thiemermann, C.; Chaudry, I.. "PRETREATMENT OF RATS WITH HEMOGLOBIN REDUCES THE MULTIPLE ORGAN INJURY CAUSED BY ENDOTOXIN.". Shock 15 Supplement (2001): 71-71. http://dx.doi.org/10.1097/00024382-200106001-00211.
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Preprint
  1. Rosa Direito; Sandra Maria Barbalho; Bruno Sepodes; Maria Eduardo Figueira. "Plant-Derived Bioactive Compounds: Exploring Neuroprotective, Metabolic, and Hepatoprotective Effects for Health Promotion and Disease Prevention". 2024. https://doi.org/10.20944/preprints202402.0641.v1.
    10.20944/preprints202402.0641.v1
Thesis / Dissertation
  1. Macedo, André Filipe Teixeira Sousa. "The regulatory and scientific challenges of digital therapeutics". Master, 2024. http://hdl.handle.net/10451/63333.
  2. Manso, Catarina Valente. "Avanços no desenvolvimento não-clínico e clínico de vacinas contra o vírus da imunodeficiência humana". Master, 2023. http://hdl.handle.net/10451/64302.
  3. Ribeiro, Joana Rodrigues. "Opportunities and regulatory challenges of phage therapy". Master, 2023. http://hdl.handle.net/10451/58528.
  4. Ferreira, Tiago André Bastos. "Avanços terapêuticos na abordagem do Linfoma de Hodgkin". Master, 2023. http://hdl.handle.net/10451/64012.
  5. Carvalhal, André da Rocha. "Avaliac¸a~o da relaça~o benefi´cio-risco na utilizaca~o de estero´ides anabolizantes". Master, 2023. http://hdl.handle.net/10451/64019.
  6. Rosi, Lorena Correia. "Enquadramento científico e regulamentar dos suplementos alimentares na Europa". Master, 2022. http://hdl.handle.net/10451/54542.
  7. Ferraz, João Miguel Nunes. "Acesso dos doentes à profilaxia de pré-exposição (PrEP) para o VIH na Europa". Master, 2022. http://hdl.handle.net/10451/63136.
  8. Alfenim, Sara Cristina Traguedo. "Geriatric medicines development: improving regulatory strategies towards establishing an evidence-based benefit-risk balance in the geriatric population". Master, 2022. http://hdl.handle.net/10451/54107.
  9. Domingos, Ana de Sousa. "Evolução regulamentar do mercado de medicamentos genéricos: análise retrospetiva do mercado português, europeu e internacional". Master, 2021. http://hdl.handle.net/10451/54066.
  10. Pereira, Carla Alexandra Guerreiro. "Therapeutic Advancements: the role of SGLT1 inhibitors in the current management of type 2 Diabetes". Master, 2021. http://hdl.handle.net/10451/52833.
  11. Felicidade, João Francisco Alves Falcão. "Therapeutic advancements in the management of HIV/AIDS". Master, 2021. http://hdl.handle.net/10451/53001.
  12. Freire, Maria Monteiro. "O papel do farmacêutico na gestão da saúde mental". Master, 2021. http://hdl.handle.net/10451/53058.
  13. Correia, Maria João Belo. "O impacto da profilaxia pré-exposição (PrEP) ao VIH na Europa". Master, 2021. http://hdl.handle.net/10451/52703.
  14. Carqueia, Cláudia Filipa Lopes. "Perfil de eficácia e segurança da isotretinoína na terapêutica em dermatologia". Master, 2021. http://hdl.handle.net/10451/52853.
  15. Pereira, Carla Alexandra Guerreiro. "Therapeutic Advancements: the role of SGLT1 inhibitors in the current management of type 2 Diabetes". Master, 2021. http://hdl.handle.net/10451/52833.
  16. Francisco, Jéssica Alexandra Pereira. "Impacto regulamentar no desenvolvimento e acesso de medicamentos para a atrofia muscular espinhal". Master, 2021. http://hdl.handle.net/10451/58222.
  17. Felicidade, João Francisco Alves Falcão. "Therapeutic advancements in the management of HIV/AIDS". Master, 2021. http://hdl.handle.net/10451/53001.
  18. Dias, Regina Simões. "Critical analysis of the worldwide regulatory tools for expedited marketing authorization". Master, 2021. http://hdl.handle.net/10451/54433.
  19. Guarino, Carolina de Vasconcelos. "HIV- infection in women, children and adolescents in Portugal". Master, 2021. http://hdl.handle.net/10451/52873.
  20. Carvalho, Marta Alexandra Bogalho Rodrigues de. "Advanced therapy medicinal products : new strategies for clinical applications of cell and gene therapy". PhD, 2020. http://hdl.handle.net/10451/48501.
  21. Tanoeiro, Beatriz de Jesus Carvalho e. "O metilfenidato no tratamento da perturbação de hiperatividade e défice de atenção em pediatria: análise da utilização off-label e problemas de segurança". Master, 2020. http://hdl.handle.net/10451/54059.
  22. Amaral, Rafael José Maia. "Evaluation of the regulatory preparedness for health threats and health crisis". Master, 2020. http://hdl.handle.net/10451/54064.
  23. Oliveira, Constança Matias de. "Neuroblastoma: approaches for the optimisation of the dose rationale for BGA002 and clinical trial design in rare paediatric diseases". Master, 2020. http://hdl.handle.net/10451/52220.
  24. Carona, Mónica Tenreiro. "The effects of cage-divided housing on anxiety and working memory in mice". Master, 2019. http://hdl.handle.net/10451/43344.
  25. Mendes, Dina Isabel Pereira. "Utilização off label de medicamentos em pediatria - desafios atuais e estratégias futuras". Master, 2019. http://hdl.handle.net/10451/54810.
  26. Almeida, Joana Filipa Coutinho do Nascimento. "Impacto da legislação pediátrica no desenvolvimento de novos medicamentos: comparação entre Europa, Estados Unidos da América e Japão". Master, 2019. http://hdl.handle.net/10451/54816.
  27. Moreira, Alexandra Isabel da Costa. "Abordagem regulamentar da Vacina Humana / Veterinária. Evolução do mercado e seus custos-benefícios". Master, 2019. http://hdl.handle.net/10451/54809.
  28. Roma, João Gabriel Mira Calhau de Carvalho. "E-commerce no setor das farmácias: case-study de desenvolvimento em Portugal". Master, 2019. http://hdl.handle.net/10451/43356.
  29. Soares, Leonor Mascarenhas Neto de Melo. "Nanjing Statements: A Formação e o Desenvolvimento de Competências do Farmacêutico para o Futuro da Profissão". Master, 2019. http://hdl.handle.net/10451/43374.
  30. Bacalhau, Patrícia Alexandra Santos. "O potencial colaborativo do farmacêutico comunitário na terapêutica do cancro da próstata". Master, 2017. http://hdl.handle.net/10451/36000.
  31. Ferreira, Pedro António Mendonça. "Ébola e Zika: lições e potenciais alterações decorrentes dos surtos". Master, 2017. http://hdl.handle.net/10451/36079.
  32. Bugalho, Ana Rita Flores. "Doenças transmissíveis, doenças não transmissíveis e os desafios do século XXI". Master, 2017. http://hdl.handle.net/10451/35944.
  33. Mateus, Vanessa. "Pharmacological modulation of inflammation associated with inflammatory bowel disease : - study in an animal model". PhD, 2016. http://hdl.handle.net/10451/24862.
  34. Antunes, Joana Filipa Mendes. "Construction of glucocorticoid receptor minigene to study alternative splicing mechanism : the role of dehydroepiandrosterone on the receptor for activated C kinase-1 expression". Master, 2016. http://hdl.handle.net/10451/34591.
  35. Fonseca, Maria Sofia Soares. "Construção de uma base de dados de estudos clínicos sobre factores de transferência". Master, 2016. http://hdl.handle.net/10451/27598.
  36. Helfrich, Alexandra Sofia Pontes Leite. "Reprogramming Fear Memory through the Inhibition of GSK-3 during Reconsolidation". Master, 2016. http://hdl.handle.net/10451/35771.
  37. Saramago, Tiago Daniel Cordeiro. "A consulta do viajante em farmácia : papel do farmacêutico no aconselhamento e terapêutica do viajante". Master, 2016. http://hdl.handle.net/10451/34509.
  38. Oliveira, Cláudia Sofia Ferraz. "Abordagem Farmacoterapêutica da fibrose quística". Master, 2015. http://hdl.handle.net/10451/26867.
  39. Guerra, Joana Filipa Salgueiro. "Potencialidades da manipulação farmacológica de órgãos sólidos para transplante". Master, 2015. http://hdl.handle.net/10451/26828.
  40. Costa, Manuel Dias. "Perspectivas terapêuticas na abordagem da esquizofrenia". Master, 2015. http://hdl.handle.net/10451/26794.
  41. Trigo, Daniel Artur Pereira da Mota dos Santos. "A utilização de medicamentos biológicos na terapêutica da asma". Master, 2015. http://hdl.handle.net/10451/46019.
  42. Moreira, Alexandra Isabel da Costa. "A qualidade do medicamento : contributos para uma abordagem diferencial entre o medicamento humano e o medicamento veterinário". Master, 2015. http://hdl.handle.net/10451/27046.
  43. Reis, Inês Antunes dos; Espadanal, Daniela. "Farmacoterapia da Depressão na Criança e no Adolescente". Master, 2015. http://hdl.handle.net/10451/26883.
  44. Cláudio, Tiago José Gomes. "Farmacoterapia da depressão em doentes com Síndrome da Imunodeficiência Adquirida". Master, 2014. http://hdl.handle.net/10451/26784.
  45. Loureiro, Joana Rebelo Mendes. "Abordagem farmacoterapêutica na fibrose quística". Master, 2014. http://hdl.handle.net/10451/26842.
  46. Páscoa, Dídia Helena Teixeira da Silva; Amaral, Sara Vieira; Ferra, Ana Maria Monteiro; Ferraz, Vanessa Alexandra Duarte. "Abordagem farmacoterapêutica da fibrose quística". Master, 2014. http://hdl.handle.net/10451/26871.
  47. Mendes, Ana Catarina Simões Martins; Lopes, Ana Raquel Gaspar Gomes Cardoso; Pinheiro, Ana Catarina Santos. "Perspectivas terapêuticas na abordagem da esquizofrenia". Master, 2014. http://hdl.handle.net/10451/26853.
  48. Silva, Fábio da Costa. "Orphan medicines and therapeutic innovation". Master, 2014. http://hdl.handle.net/10451/26906.
  49. Espadanal, Daniela. "Farmacoterapia da depressão em crianças e adolescentes". Master, 2014. http://hdl.handle.net/10451/25724.
  50. Ambaram, Miguel Bhatt. "Terapêutica da diabetes mellitus do tipo 2". Master, 2014. http://hdl.handle.net/10451/26748.
  51. Raposo, Carla Sofia Alexandre. "O papel das normas de orientação clínica no uso racional do medicamento em oncologia". Master, 2014. http://hdl.handle.net/10451/15860.
  52. Cândido, Sara Filipa Fernandes. "Fisiopatologia e terapêutica da dor neuropática". Master, 2013. http://hdl.handle.net/10451/46030.
  53. Repolho, Marta Batista da Rosa. "Imunoterapia na artrite reumatóide em Portugal : avanços terapêuticos, riscos e benefícios". Master, 2013. http://hdl.handle.net/10451/15295.
  54. Raposo, João Paulo Freire de Carvalho e Castro. "Abordagem farmacoterapêutica das doenças inflamatórias do intestino". Master, 2013. http://hdl.handle.net/10451/46025.
  55. Salgueiro, Catarina Vicente Barroso Reis. "Efeito terapêutico de agonistas dos receptores canabinóides". Master, 2013. http://hdl.handle.net/10451/46185.
  56. Nogueira , João André Jorge. "A utilização de anticorpos na terapêutica antitumoral". Master, 2013. http://hdl.handle.net/10451/30599.
  57. Rocha, João Pedro Fidalgo, 1982-. "Inflamação e mecanismos citoprotectores em modelos de lesão pulmonar". PhD, 2013. http://hdl.handle.net/10451/9267.
  58. Russo, Joana Isabel Silveira. "Nefrotoxicidade induzida por fármacos: caracterização da realidade hospitalar, medidas preventivas e oportunidades de intervenção". Master, 2013. http://hdl.handle.net/10451/11257.
  59. Requetim, Luís Ricardo Charneca. "A utilização em terapêutica de substâncias com atividade nootrópica". Master, 2013. http://hdl.handle.net/10400.1/6885.
  60. Santos, Sara Manuela Barreiros dos. "Imunoterapia oncológica: avanços terapêuticos, riscos e benefícios". Master, 2013. http://hdl.handle.net/10451/24607.
  61. Amorim, Daniela Sofia Rodrigues. "A terapêutica da dor neuropática em Portugal: proposta de uma linha orientadora de uniformização". Master, 2012. http://hdl.handle.net/10451/11309.
  62. Henriques, Sónia Isabel Gonçalves. "Implementação de um painel de provadores de alimentos. Comparação dos hábitos de consumo alimentar e acuidade sensorial de dois grupos de indivíduos". Master, 2012. http://hdl.handle.net/10451/11355.
  63. Apolinário, Célia Luísa dos Santos. "Farmacoterapia no cancro da mama". Master, 2012. http://hdl.handle.net/10400.1/3521.
  64. Damásio, Mariana Peig Dória. "Farmacoterapia das perturbações do sono: insónia". Master, 2011. http://hdl.handle.net/10400.1/2724.
  65. Freitas, Cassius Francisco de Andrade. "Avaliação da atividade anti-inflamatória de um extrato de framboesa na Artrite Reumatóide". Master, 2011. http://hdl.handle.net/10451/11010.
  66. Costa, Cátia Sofia Piriquito. "Contraceptivos orais". Master, 2011. http://hdl.handle.net/10400.1/1757.
  67. Santos, Inês Isabel Carromeu. "Terapêutica hormonal de substituição". Master, 2010. http://hdl.handle.net/10400.1/12187.
  68. Sepodes, Bruno Miguel Nogueira, 1977-. "Modulação farmacológica da lesão induzida por isquémia- reperfusão hepática". PhD, 2008. http://sibul.reitoria.ul.pt/F/?func=item-global&doc_library=ULB01&type=03&doc_number=000533091.

Intellectual property

Patent
  1. Ana Rita Jesus; Amélia Pilar Rauter; Alice Martins; Ribeiro, Rogério T.; Maria Paula Macedo; Catarina Dias; Jorge Justino; et al. 2017. "New C-glycosylpolyphenol antidiabetic agents, effect on glucose tolerance and interaction with beta-amyloid. Therapeutic applications of the synthesized agent(s) and of Genista tenera ethyl acetate extracts containing some of those agents".
    Granted/Issued
Distinctions

Award

2021 Prémio Almofariz - FIGURA DO ANO (Personality of the Year)
Revista Farmácia Distribuição - Netfarma, Portugal
2018 EURORDIS Leadership Black Pearl Award
European Organisation for Rare Diseases, France

Other distinction

2012 Nutrition Awards 2012 – 1a Menção Honrosa
Fundação Calouste Gulbenkian, Portugal
2010 Arthur E. Baue Award
2009 2nd Poster Prize at the 21st DIA Annual Euromeeting 2009
2007 Menção honrosa do prémio das comunicações livres
Sociedade Portuguesa de Cirurgia, Portugal
2007 Prémio Ana Maria Correia
2006 Prémio da Melhor Comunicação Livre
2005 1º Prémio das Comunicações Livres (Investigação Experimental)
2002 Young Scientist Award
1998 Prémio Natiris de Fitoterapia