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My main research interests are related with the "immortal" germ line lineage and female fertility. More specifically, the regulation of gene expression during oogenesis and early embryonic development. I also have a strong interest in meiotic recombination, DNA repair and mitosis. My research group mostly uses Drosophila melanogaster as our model organism. I did my BSc (5 years) in plant biology at the University of Lisbon (Portugal) and my PhD research under the supervision of Antony Carr (University of Sussex, UK), where I worked with DNA damage checkpoints in fission yeast. My postdoctoral research was done under the supervision of Ruth Lehmann (Skirball Institute of Biomolecular Medicine, New York, USA), where I worked on the regulation of gene expression during Drosophila primordial germ cells segregation. I established my research group at Instituto Gulbenkian de Ciencia (IGC) in 2006, and have since moved first to the University of Algarve, Portugal (where I got tenure) and recently to the University of Aveiro (Portugal).
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Identification

Personal identification

Full name
Rui Gonçalo Viegas Russo da Conceição Martinho

Citation names

  • Martinho, Rui Gonçalo

Author identifiers

Ciência ID
F31D-C783-3D89
ORCID iD
0000-0002-1641-3403

Addresses

  • Universidade de Aveiro, Departamento de Ciência Médicas, Campus Universitario de Santiago, Agra do Crasto - Edificio 30, 3810-193, Aveiro, Aveiro, Portugal (Professional)

Websites

Knowledge fields

  • Natural sciences - Biological Sciences - Developmental Biology
Education
Degree Classification
1995/10/01 - 2000/01/28
Concluded
 Biologia / Biology (Doctor of Philosophy)
University of Sussex, United Kingdom
"Analysis of Rad3 and Chk1 checkpoint protein kinases " (THESIS/DISSERTATION)
1989/10/01 - 1994/07/14
Concluded
 Biol. Vegetal e Aplicada / Plant Biology (Licenciatura)
Major in Biologia Vegetal e Aplicada
Universidade de Lisboa Faculdade de Ciências, Portugal
 18 (out of 20)
Affiliation

Science

Category
Host institution 		Employer
2008/04/01 - 2011/08/31 Contracted Researcher (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2006/01/01 - 2008/03/31 Postdoc (Research) Instituto Gulbenkian de Ciência, Portugal
Instituto Gulbenkian de Ciência, Portugal
2000 - 2005 Postdoc (Research) New York University Skirball Institute of Biomolecular Medicine, United States
New York University Skirball Institute of Biomolecular Medicine, United States

Teaching in Higher Education

Category
Host institution 		Employer
2024/08/15 - Current Associate Professor (University Teacher) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
Universidade de Aveiro Instituto de Biomedicina, Portugal
2018/09/01 - 2024/08/14 Assistant Professor (University Teacher) Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2011/09/01 - 2018/08/31 Assistant Professor (University Teacher) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal
2011/01/01 - 2011/07/31 Invited Assistant Professor (University Teacher) Universidade do Algarve Departamento de Ciências Biomédicas e Medicina, Portugal

Positions / Appointments

Category
Host institution 		Employer
2022/06/01 - Current Membro do Conselho do Departamento de Ciências Médicas Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018/10/23 - Current Director do Programa Doutoral em Biomedicina / Director of the Doctoral Program in Biomedicine Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2018/10/23 - 2024/03/15 Membro da Comissão Executiva do Departamento de Ciências Médicas / Member of the Executive Committee of the Department of Medical Sciences Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2016/04/15 - 2018/08/31 Conselho pedagógico do Departamento de Ciências Biomédicas e Medicina / Pedagogical Council of the Department of Biomedical Sciences and Medicine Universidade do Algarve, Portugal
2012/07/13 - 2018 Conselho científico do Departamento de Ciências Biomédicas e Medicina / Scientific Council of the Department of Biomedical Sciences and Medicine Universidade do Algarve, Portugal
Outputs

Publications

Book chapter
  1. Marques, Bruno; Matos, Ricardo; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Oogenesis Signaling from Development to Environmental Plasticity and Aging". In Tissue-Specific Cell Signaling, 317-336. Springer International Publishing, 2020.
    Published • 10.1007/978-3-030-44436-5_11
  2. Marques, Bruno; Matos, Ricardo; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Regulation of the Oocyte Epigenome During Prophase I Arrest". In Encyclopedia of Reproduction, edited by Skinner, Michael K., 218-224. Elsevier, 2018.
    Published • 10.1016/b978-0-12-801238-3.64457-4
  3. Martinho, Rui Gonçalo; Carr, Antony M.. "Isolation of DNA Structure-Dependent Checkpoint Mutants in S. pombe". In DNA Repair Protocols, edited by Henderson, Daryl S., 1-9. Humana Press, 1999.
    Published • 10.1385/1-59259-675-4:1
Journal article
  1. Varland, Sylvia; Silva, Rui Duarte; Kjosås, Ine; Faustino, Alexandra; Bogaert, Annelies; Billmann, Maximilian; Boukhatmi, Hadi; et al. Corresponding author: Martinho, Rui Gonçalo. "N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity". Nature Communications 14 1 (2023): http://dx.doi.org/10.1038/s41467-023-42342-y.
    Open access • Published • 10.1038/s41467-023-42342-y
  2. Carmo, Catarina; Coelho, João; Silva, Rui D; Tavares, Alexandra; Boavida, Ana; Gaetani, Paola; Guilgur, Leonardo G; Martinho, Rui Gonçalo; Oliveira, Raquel A. Corresponding author: Oliveira, Raquel A. "A dual-function SNF2 protein drives chromatid resolution and nascent transcript removal in mitosis". EMBO reports 24 9 (2023): http://dx.doi.org/10.15252/embr.202256463.
    Open access • Published • 10.15252/embr.202256463
  3. Cabrita, Brigite; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Genetic and Epigenetic Regulation of Drosophila Oocyte Determination". Journal of Developmental Biology 11 2 (2023): 21. http://dx.doi.org/10.3390/jdb11020021.
    Open access • Published • 10.3390/jdb11020021
  4. Feijão, Tália; Marques, Bruno; Silva, Rui D.; Carvalho, Célia; Sobral, Daniel; Matos, Ricardo; Tan, Tian; et al. Corresponding author: Martinho, Rui Gonçalo. "Polycomb group (PcG) proteins prevent the assembly of abnormal synaptonemal complex structures during meiosis". Proceedings of the National Academy of Sciences 119 42 (2022): http://dx.doi.org/10.1073/pnas.2204701119.
    Open access • Published • 10.1073/pnas.2204701119
  5. Prudêncio, Pedro; Savisaar, Rosina; Rebelo, Kenny; Martinho, Rui Gonçalo; Carmo-Fonseca, Maria. Corresponding author: Martinho, Rui Gonçalo. "Transcription and splicing dynamics during early Drosophila development". RNA 28 2 (2022): 139-161. http://dx.doi.org/10.1261/rna.078933.121.
    Open access • Published • 10.1261/rna.078933.121
  6. Gomes, Teresa Lopes; Oliveira-Marques, Virgínia de; Hampson, Richard John; Jacinto, António; de Moraes, Luciana Vieira; Martinho, Rui Gonçalo. Corresponding author: de Moraes, Luciana Vieira. "theLiTE™: A Screening Platform to Identify Compounds that Reinforce Tight Junctions". Frontiers in Pharmacology 12 (2022): http://dx.doi.org/10.3389/fphar.2021.752787.
    Open access • Published • 10.3389/fphar.2021.752787
  7. Rathore, Om Singh; Silva, Rui D.; Ascensão-Ferreira, Mariana; Matos, Ricardo; Carvalho, Célia; Marques, Bruno; Tiago, Margarida N.; et al. Corresponding author: Martinho, Rui Gonçalo. "NineTeen Complex-subunit Salsa is required for efficient splicing of a subset of introns and dorsal–ventral patterning". RNA 26 12 (2020): 1935-1956. http://dx.doi.org/10.1261/rna.077446.120.
    Open access • Published • 10.1261/rna.077446.120
  8. Prudêncio, Pedro; Rebelo, Kenny; Grosso, Ana Rita; Martinho, Rui Gonçalo; Carmo-Fonseca, Maria. Corresponding author: Carmo-Fonseca, Maria. "Analysis of Mammalian Native Elongating Transcript sequencing (mNET-seq) high-throughput data". Methods 178 (2020): 89-95. http://dx.doi.org/10.1016/j.ymeth.2019.09.003.
    Open access • Published • 10.1016/j.ymeth.2019.09.003
  9. Navarro-Costa, Paulo; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "The emerging role of transcriptional regulation in the oocyte-to-zygote transition". PLOS Genetics 16 3 (2020): e1008602. http://dx.doi.org/10.1371/journal.pgen.1008602.
    Open access • Published • 10.1371/journal.pgen.1008602
  10. Silva, Rui D.; Mirkovic, Mihailo; Guilgur, Leonardo G.; Rathore, Om S.; Martinho, Rui Gonçalo; Oliveira, Raquel A.. Corresponding author: Martinho, Rui Gonçalo. "Absence of the Spindle Assembly Checkpoint Restores Mitotic Fidelity upon Loss of Sister Chromatid Cohesion". Current Biology 28 17 (2018): 2837-2844.e3. http://dx.doi.org/10.1016/j.cub.2018.06.062.
    Open access • Published • 10.1016/j.cub.2018.06.062
  11. Prudêncio, Pedro; Guilgur, Leonardo G; Sobral, João; Becker, Jörg D; Martinho, Rui Gonçalo; Navarro-Costa, Paulo. Corresponding author: Martinho, Rui Gonçalo. "The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization". EMBO reports 19 8 (2018): http://dx.doi.org/10.15252/embr.201845728.
    Open access • Published • 10.15252/embr.201845728
  12. Ribeiro, Ana Luisa; Silva, Rui D.; Foyn, Håvard; Tiago, Margarida N.; Rathore, Om Singh; Arnesen, Thomas; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Naa50/San-dependent N-terminal acetylation of Scc1 is potentially important for sister chromatid cohesion". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep39118.
    Open access • Published • 10.1038/srep39118
  13. Navarro-Costa, Paulo; McCarthy, Alicia; Prudêncio, Pedro; Greer, Christina; Guilgur, Leonardo G.; Becker, Jörg D.; Secombe, Julie; Rangan, Prashanth; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Early programming of the oocyte epigenome temporally controls late prophase I transcription and chromatin remodelling". Nature Communications 7 1 (2016): http://dx.doi.org/10.1038/ncomms12331.
    Open access • Published • 10.1038/ncomms12331
  14. Rathore, Om Singh; Faustino, Alexandra; Prudêncio, Pedro; Van Damme, Petra; Cox, Cymon J.; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms". Scientific Reports 6 1 (2016): http://dx.doi.org/10.1038/srep21304.
    Open access • Published • 10.1038/srep21304
  15. Silva, Rui D.; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Developmental roles of protein N-terminal acetylation". PROTEOMICS 15 14 (2015): 2402-2409. http://dx.doi.org/10.1002/pmic.201400631.
    Open access • Published • 10.1002/pmic.201400631
  16. Martinho, Rui Gonçalo; Guilgur, Leonardo G.; Prudêncio, Pedro. Corresponding author: Martinho, Rui Gonçalo. "How gene expression in fast-proliferating cells keeps pace". BioEssays 37 5 (2015): 514-524. http://dx.doi.org/10.1002/bies.201400195.
    Open access • Published • 10.1002/bies.201400195
  17. Ferreira, Tânia; Prudêncio, Pedro; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Drosophila protein kinase N (Pkn) is a negative regulator of actin–myosin activity during oogenesis". Developmental Biology 394 2 (2014): 277-291. http://dx.doi.org/10.1016/j.ydbio.2014.08.008.
    Open access • Published • 10.1016/j.ydbio.2014.08.008
  18. Pereira, P.A.; Navarro-Costa, P.; Martinho, Rui Gonçalo; Becker, J.D.. "Evolutionarily conserved mechanisms of male germline development in flowering plants and animals". Biochemical Society Transactions 42 2 (2014): 377-382.
    Published • 10.1042/BST20130261
  19. Guilgur, L.G.; Prudêncio, P.; Sobral, D.; Liszekova, D.; Rosa, A.; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Requirement for highly efficient pre-mRNA splicing during Drosophila early embryonic development". eLife 2014 3 (2014):
    Open access • Published • 10.7554/eLife.02181.001
  20. Alves, Ema; Henriques, Bárbara J.; Rodrigues, João V.; Prudêncio, Pedro; Rocha, Hugo; Vilarinho, Laura; Martinho, Rui Gonçalo; Gomes, Cláudio M.. Corresponding author: Martinho, Rui Gonçalo. "Mutations at the flavin binding site of ETF:QO yield a MADD-like severe phenotype in Drosophila". Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1822 8 (2012): 1284-1292. http://dx.doi.org/10.1016/j.bbadis.2012.05.003.
    Open access • Published • 10.1016/j.bbadis.2012.05.003
  21. Guilgur, L. G.; Prudencio, P.; Ferreira, T.; Pimenta-Marques, A. R.; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Drosophila aPKC is required for mitotic spindle orientation during symmetric division of epithelial cells". Development 139 3 (2012): 503-513. http://dx.doi.org/10.1242/dev.071027.
    Open access • Published • 10.1242/dev.071027
  22. Van Damme, Petra; Hole, Kristine; Pimenta-Marques, Ana; Helsens, Kenny; Vandekerckhove, Joël; Martinho, Rui Gonçalo; Gevaert, Kris; Arnesen, Thomas. "NatF Contributes to an Evolutionary Shift in Protein N-Terminal Acetylation and Is Important for Normal Chromosome Segregation". PLoS Genetics 7 7 (2011): e1002169. http://dx.doi.org/10.1371/journal.pgen.1002169.
    Open access • Published • 10.1371/journal.pgen.1002169
  23. de las Heras, José Manuel; Martinho, Rui Gonçalo; Lehmann, Ruth; Casanova, Jordi. "A functional antagonism between the pgc germline repressor and torso in the development of somatic cells". EMBO reports 10 9 (2009): 1059-1065. http://dx.doi.org/10.1038/embor.2009.128.
    Open access • Published • 10.1038/embor.2009.128
  24. Rangan, Prashanth; DeGennaro, Matthew; Jaime-Bustamante, Kean; Coux, Rémi- Xavier; Martinho, Rui Gonçalo; Lehmann, Ruth. "Temporal and Spatial Control of Germ-Plasm RNAs". Current Biology 19 1 (2009): 72-77. http://dx.doi.org/10.1016/j.cub.2008.11.066.
    Open access • Published • 10.1016/j.cub.2008.11.066
  25. Pimenta-Marques, Ana; Tostões, Rui; Marty, Thomas; Barbosa, Vítor; Lehmann, Ruth; Martinho, Rui Gonçalo. Corresponding author: Martinho, Rui Gonçalo. "Differential requirements of a mitotic acetyltransferase in somatic and germ line cells". Developmental Biology 323 2 (2008): 197-206. http://dx.doi.org/10.1016/j.ydbio.2008.08.021.
    Open access • Published • 10.1016/j.ydbio.2008.08.021
  26. Martinho, Rui Gonçalo; Kunwar, Prabhat S.; Casanova, Jordi; Lehmann, Ruth. "A Noncoding RNA Is Required for the Repression of RNApolII-Dependent Transcription in Primordial Germ Cells". Current Biology 14 2 (2004): 159-165. http://dx.doi.org/10.1016/j.cub.2003.12.036.
    Open access • Published • 10.1016/j.cub.2003.12.036
  27. Read, R. L.; Martinho, Rui Gonçalo; Wang, S.-W.; Carr, A. M.; Norbury, C. J.. "Cytoplasmic poly(A) polymerases mediate cellular responses to S phase arrest". Proceedings of the National Academy of Sciences 99 19 (2002): 12079-12084. http://dx.doi.org/10.1073/pnas.192467799.
    Open access • Published • 10.1073/pnas.192467799
  28. Christensen, P. U.; Bentley, N. J.; Martinho, Rui Gonçalo; Nielsen, O.; Carr, A. M.. "Mik1 levels accumulate in S phase and may mediate an intrinsic link between S phase and mitosis". Proceedings of the National Academy of Sciences 97 6 (2000): 2579-2584. http://dx.doi.org/10.1073/pnas.97.6.2579.
    Open access • Published • 10.1073/pnas.97.6.2579
  29. Martinho, Rui Gonçalo; Lindsay, H. D.; Flaggs, G.; DeMaggio, A. J.; Hoekstra, M. F.; Carr, A. M.; Bentley, N. J.. "Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses". The EMBO Journal 17 24 (1998): 7239-7249. http://dx.doi.org/10.1093/emboj/17.24.7239.
    Open access • Published • 10.1093/emboj/17.24.7239
  30. Martinho, Rui Gonçalo; Castel, S; Ureña, J; Fernández-Borja, M; Makiya, R; Olivecrona, G; Reina, M; Alonso, A; Vilaró, S. "Ligand binding to heparan sulfate proteoglycans induces their aggregation and distribution along actin cytoskeleton.". Molecular Biology of the Cell 7 11 (1996): 1771-1788. http://dx.doi.org/10.1091/mbc.7.11.1771.
    Open access • Published • 10.1091/mbc.7.11.1771
Preprint
  1. Carmo, Catarina; Coelho, João; Silva, Rui; Tavares, Alexandra; Boavida, Ana; Gaetani, Paola; Martinho, Rui Gonçalo; Oliveira, Raquel A.. Corresponding author: Oliveira, Raquel A.. "An SNF2 helicase-like protein links mitotic transcription termination to sister chromatid resolution". 2022. http://dx.doi.org/10.1101/2022.11.21.517340.
    10.1101/2022.11.21.517340
  2. Varland, Sylvia; Silva, Rui Duarte; Kjosås, Ine; Faustino, Alexandra; Bogaert, Annelies; Billmann, Maximilian; Boukhatmi, Hadi; et al. Corresponding author: Martinho, Rui Gonçalo. "N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity". 2022. http://dx.doi.org/10.1101/2022.09.01.505523.
    10.1101/2022.09.01.505523
  3. Prudêncio, Pedro; Savisaar, Rosina; Rebelo, Kenny; Martinho, Rui Gonçalo; Carmo-Fonseca, Maria. Corresponding author: Martinho, Rui Gonçalo. "Transcription and splicing dynamics during early Drosophila development". 2020. http://dx.doi.org/10.1101/2020.11.05.367888.
    10.1101/2020.11.05.367888
  4. Prudêncio, Pedro; Guilgur, Leonardo G.; Sobral, João; Becker, Jörg D.; Martinho, Rui Gonçalo; Navarro-Costa, Paulo. Corresponding author: Martinho, Rui Gonçalo. "The Trithorax group protein dMLL3/4 instructs the assembly of the zygotic genome at fertilization". 2018. http://dx.doi.org/10.1101/242008.
    10.1101/242008

Intellectual property

Patent
  1. Martinho, Rui Gonçalo; Marques, Virginia Mylena de Oliveira; Hampson, Richard John. 2016. "Method for identifying cancer drug candidates in Drosophila". United States.
    Granted/Issued