Personal identification

Full name

João Pedro da Costa Alvares Viegas Nunes

Author identifiers

Ciência ID

F413-C6F8-AFF1

ORCID iD

0000-0003-0127-5420

Researcher Id

Q-8648-2017

Scopus Author Id

55974674700

Websites

• https://www.linkedin.com/in/joao-costa-nunes/ (Professional)
• https://www.researchgate.net/profile/Joao_Costa-Nunes (Professional)

Knowledge fields

• Natural sciences - Biological Sciences - Behavioural Sciences Biology
• Medical and Health Sciences - Basic Medicine - Neurosciences
• Medical and Health Sciences - Clinical Medicine - Cardiac and Cardiovascular Systems

Languages

Language	Speaking	Reading	Writing	Listening	Peer-review
Portuguese (Mother tongue)
English	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)	Proficiency (C2)

	Degree	Classification
2017/11/01 - 2018/12/31 Concluded	Visiting Behavioral Expert (Pós-doutoramento) Instituto de Medicina Molecular, Portugal
2018 - 2018 Concluded	Hands-On the Rodent Brain (Outros) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/04/01 - 2016/10 Concluded	Diabetes, aging and metabolic complications (Pós-doutoramento) CNC.IBILI, Portugal
2016 - 2016 Concluded	Cell Culture and Tissue Training Course (Outros) Centro de Neurociências e Biologia Celular da Universidade de Coimbra, Portugal
2015/01/06 - 2015/12/21 Concluded	Translational Neuroscience (Doutoramento) Universiteit Maastricht School for Mental Health and Neuroscience, Netherlands "Insulin receptor sensitization improves affective pathology in various mouse models" (THESIS/DISSERTATION)	N/A
2012 - 2012 Concluded	Fundamentals of Neuroscience (Outros) Instituto de Ciências da Vida e da Saúde / Escola de Ciências da Saúde, Portugal
2008/10/01 - 2011/05/19 Concluded	Biologia Humana e Ambiente (Mestrado integrado) Universidade de Lisboa Faculdade de Ciências, Portugal "Behavioural effects of chronic administration of imipramine in food and water regarding anxiety and depression paradigms on naïve C57BL/6N male mice (Defesa com 19 val.)" (THESIS/DISSERTATION)	17 Valores
2009 - 2009 Concluded	Laboratory Animal Science FELASA Classe C (80h) (Título de Habilitação de Coordenação Científica) Instituto de Biologia Celular e Molecular, Portugal
2008 - 2008 Concluded	Internship (Outros) Instituto Gulbenkian de Ciência, Portugal
2004/09/06 - 2007/09/11 Concluded	Biologia (Licenciatura) Major in Biologia Evolutiva e Desenvolvimento Universidade de Lisboa Faculdade de Ciências, Portugal "n/a (Bolonha)" (THESIS/DISSERTATION)	13 Valores

Science

	Category Host institution	Employer
2017/06/13 - Current	Researcher (Research)	Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova Institut molekularnoj mediciny, Russia

Grant

	Designation	Funders
2018/09 - Current	The role of isotopic water composition, Western diet and genetic serotonin transporter deficiency in metabolic and affective disorders during aging N/A Principal investigator Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova Institut molekularnoj mediciny, Russia	Rossijskij fond fundamental'nyh issledovanij Ongoing
2018/07 - Current	Effects of Dicholine Fumarate on Experimental Autoimmune Encephalomyelitis (EAE) in the Mouse: study on C57Bl/6 female mice. n/a Invited Scientist Fellow Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova Institut regenerativnoj mediciny, Russia	Rossijskij fond fundamental'nyh issledovanij
2018 - Current	A study of the mechanisms of aggression in the mouse model of genetic deficit of a key enzyme in the synthesis of serotonin in the central nervous system: a study of the role of stress. n/a Post-doc Fellow Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova Institut molekularnoj mediciny, Russia

Contract

	Designation	Funders
2017/11 - Current	Behavioral characterization of FUS-tg mouse model of ALS. N/A Principal investigator Pervyj Moskovskij gosudarstvennyj medicinskij universitet imeni I M Secenova Institut molekularnoj mediciny, Russia	Neuroplast BV Ongoing

Publications

Conference poster	de Munter J; JP Costa-Nunes. "Functional and molecular changes induced by intrathecal administration of autologous stem cells (Neuro-CELLS) in a balloon compressed spinal cord injury rat model". Paper presented in Annual Scientific Meeting of Clinical Proteomics and Postgenome Medicine, 2017. JP Costa-Nunes. "Distinct opposing effects of predation stress on aggressive behavior of Tph2 het and wild type mice". Paper presented in New Horizons in Psychopharmacology: from basic research to clinical application., 2015. Dong, P.; Rawls, G.. "Distinct opposing effects of predation stress on aggressive behavior of Tph2 het and wild type mice.". Paper presented in 3rd General Assembly Meeting of the AGGRESSOTYPE consortium, 2015. 10.1115/pvp2003-2046
Journal article	Nunes, João. "Insulin receptor in the brain: Mechanisms of activation and the role in the CNS pathology and treatment". CNS Neuroscience and Therapeutics (2018): 10.1111/cns.12866 Nunes, João. "Effects of voluntary imipramine intake via food and water in paradigms of anxiety and depression in naïve mice". Translational Neuroscience and Clinics (2016): 10.18679/CN11-6030/R.2016.018 Strekalova T; Costa-Nunes JP; Veniaminova E; Kubatiev A; Lesch KP; Chekhonin VP; Evans MC; Steinbusch HW. "Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice.". (2016): http://europepmc.org/abstract/med/26921863. 10.1016/j.jad.2016.02.045 Strekalova T; Evans M; Costa-Nunes J; Bachurin S; Yeritsyan N; Couch Y; Steinbusch HM; et al. "Tlr4 upregulation in the brain accompanies depression- and anxiety-like behaviors induced by a high-cholesterol diet.". (2015): http://europepmc.org/abstract/med/25712260. 10.1016/j.bbi.2015.02.015 Costa-Nunes JP; Cline BH; Araújo-Correia M; Valença A; Markova N; Dolgov O; Kubatiev A; et al. "Animal Models of Depression and Drug Delivery with Food as an Effective Dosing Method: Evidences from Studies with Celecoxib and Dicholine Succinate.". (2015): http://europepmc.org/abstract/med/26064929. 10.1155/2015/596126 Cline BH; Costa-Nunes JP; Cespuglio R; Markova N; Santos AI; Bukhman YV; Kubatiev A; et al. "Dicholine succinate, the neuronal insulin sensitizer, normalizes behavior, REM sleep, hippocampal pGSK3 beta and mRNAs of NMDA receptor subunits in mouse models of depression.". (2015): http://europepmc.org/abstract/med/25767439. 10.3389/fnbeh.2015.00037 Strekalova T; Evans M; Chernopiatko A; Couch Y; Costa-Nunes J; Cespuglio R; Chesson L; et al. "Deuterium content of water increases depression susceptibility: The potential role of a serotonin-related mechanism.". (2014): http://europepmc.org/abstract/med/25092571. 10.1016/j.bbr.2014.07.039 Costa-Nunes J; Zubareva O; Araújo-Correia M; Valença A; Schroeter CA; Pawluski JL; Vignisse J; et al. "Altered emotionality, hippocampus-dependent performance and expression of NMDA receptor subunit mRNAs in chronically stressed mice.". (2014): http://europepmc.org/abstract/med/24308441. 10.3109/10253890.2013.872619 Markova N; Chernopiatko A; Schroeter CA; Malin D; Kubatiev A; Bachurin S; Costa-Nunes J; Steinbusch HM; Strekalova T. "Hippocampal gene expression of deiodinases 2 and 3 and effects of 3,5-diiodo-L-thyronine T2 in mouse depression paradigms.". (2013): http://europepmc.org/abstract/med/24386638. 10.1155/2013/565218 Pawluski JL; Valença A; Santos AI; Costa-Nunes JP; Steinbusch HW; Strekalova T. "Pregnancy or stress decrease complexity of CA3 pyramidal neurons in the hippocampus of adult female rats.". (2012): http://europepmc.org/abstract/med/23036618. 10.1016/j.neuroscience.2012.09.059 Vignisse J; Steinbusch HW; Bolkunov A; Nunes J; Santos AI; Grandfils C; Bachurin S; Strekalova T. "Dimebon enhances hippocampus-dependent learning in both appetitive and inhibitory memory tasks in mice.". (2011): http://europepmc.org/abstract/med/21163318. 10.1016/j.pnpbp.2010.12.007
Thesis / Dissertation	JP Costa-Nunes. "Insulin receptor sensitization improves affective pathology in various mouse models". PhD, Universiteit Maastricht School for Mental Health and Neuroscience, 2015. https://cris.maastrichtuniversity.nl/portal/en/publications/insulin-receptor-sensitization-improves-affective-pathology-in-various-mouse-models(503e46df-e23c-4f59-a7cf-219d01417fb3).html. JP Costa-Nunes. "Behavioural effects of chronic administration of Imipramine in food and water regarding anxiety and depression paradigms on naïve C57BL/6N male mice". Master, Universidade de Lisboa Faculdade de Ciências, 2011. http://hdl.handle.net/10451/3508.