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José Luis Costa carried out his undergraduate studies at the University of Porto in Portugal (1998) and obtained his Ph.D. degree in Biology at Uppsala University in Sweden (2004). Prior to joining the Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP) in 2006, he carried out postdoctoral research at the Vrije University Medical Center in Amsterdam, The Netherlands. In 2014, he was appointed as Affiliated Professor at the Medical Faculty of the University of Porto. Currently he is a Principal Researcher at the Institute of Molecular Pathology and Immunology of the University of Porto and Scientific Coordinator of the Genomics Platform of the Institute for Research and Innovation in Health, Porto. During his academic and scientific career, he has published 35 papers in international peer reviewed journals with a corresponding H-index of 19. He has been able to attract competitive funding and was awarded with three prizes, one from the prestigious Royal Swedish Academy of Sciences, another from the Portuguese Society of Oncology and in 2018 the Pfizer award for Clinical Research. He has supervised several Master students both in Amsterdam and Porto. He is currently the supervisor of two PhD students and co-supervisor of two PhD students. He is enrolled in several International Societies, most importantly was founding member of the International Society of Liquid Biopsy and European Liquid Biopsy Society. Scientifically his career has focused on understanding the crucial events that are the basis for the development and progression of cancer. To develop his work, he uses diverse genomic techniques, ranging from basic molecular biology tools to high-throughput technologies. Currently, he aims to deepen his translational research in order to be able to contribute with his knowledge of genomics for the benefit of patients through the application of the latest technologies in the diagnosis and the search for personalized therapy.
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Identification

Personal identification

Full name
José Luis da Silva Borges Costa

Citation names

  • Costa, José Luis

Author identifiers

Ciência ID
F518-0A2A-CD9D
ORCID iD
0000-0001-7132-4094
Researcher Id
B-7126-2008
Scopus Author Id
55937368000

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
Swedish Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
French Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2001 - 2004
Concluded
 - (Doutoramento)
Uppsala Universitet, Sweden
"The tRNALeu (UAA) intron of cyanobacteria. Towards understanding a genetic marker." (THESIS/DISSERTATION)
 Pass
1993 - 1998
Concluded
 Biologia (Licenciatura)
Universidade do Porto Faculdade de Ciências, Portugal
 13 valores
Affiliation

Science

Category
Host institution 		Employer
2016/01/01 - Current Auxiliary Researcher (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2014/01/01 - 2015/12/31 Auxiliary Researcher (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2006/11/01 - 2013/12/31 Postdoc (Research) Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2005/10/01 - 2006/10/31 Postdoc (Research) Vrije Universiteit Medical Centre, Netherlands
2004/10/19 - 2005/09/30 Postdoc (Research) Vrije Universiteit Medical Centre, Netherlands
1998/10/01 - 1999/02/28 Visiting Researcher (Research) Uppsala Universitet, Sweden

Teaching in Higher Education

Category
Host institution 		Employer
2014/03/01 - Current Visiting Professor (University Teacher) Universidade do Porto Faculdade de Medicina, Portugal
2001/01/01 - 2003/12/31 Tutor (University Teacher) Uppsala Universitet, Sweden

Others

Category
Host institution 		Employer
2016/01/01 - Current Coordenador cientifico plataforma Genómica Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
1999/05/01 - 2000/08/31 Investigador auxiliar Laboratórios Bial, Portugal
Projects

Contract

Designation Funders
2018/07 - 2021/07 Lung Cancer Screening - A non-invasive methodology for early diagnosis
PTDC/EMD-EMD/30263/2017
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal

Instituto de Engenharia de Sistemas e Computadores Tecnologia e Ciência, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07 - 2021/07 Neoantigen signature algorithm to predict immunotherapy response
PTDC/MEC-ONC/32018/2017
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
Ongoing
2018/07 - 2021/07 Tregs in cancer immune response
PTDC/MED-PAT/32462/2017
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2018/07 - 2021/06 Microbiome-derived metabolites as new gastric cancer biomarkers
PTDC/MED-OUT/32532/2017
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2018/07 - 2021/06 Determining the Role of the Microenvironment in Shaping the Spectrum of Genetic Mutations Acquired During Cancer Development
PTDC/MED-ONC/32592/2017
Provided by PTCRIS: 125206
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2016/01 - 2019/08 Horizontal transmission of drug resistance: a game changer in the clinical management of cancer patients
Provided by PTCRIS: 141126
Principal investigator
Fundação para a Ciência e a Tecnologia
2016/06 - 2019/05 Gastric Microbiota & Cancer: More than Helicobacter pylori
WCR-16-1352
Researcher
Worldwide Cancer Research, United Kingdom
 Worldwide Cancer Research
2016 - 2019 Detection of tumor biomarkers using circulating tumor cell-free nucleic acids
NORTE-01-0145-FEDER-000029
Principal investigator
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Ongoing
2016/01 - 2018/12 The Role of Exosomes in Tumor Heterogeneity: More than Just Bubbling
Provided by PTCRIS: 141380
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2016/01 - 2018/12 The yin and yang of somatic mutations in cancer immunosurveillance
Provided by PTCRIS: 141461
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Fundação para a Ciência e a Tecnologia
2016 - 2017 Assessment of Somatic Alterations in Plasma of lung cancer patients
FIS-FIS-2015-01_ONC
Researcher
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
 Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP
Concluded
2013 - 2015 Portuguese study of familial dilated cardiomyopathies
PTDC/BIM-MEC/0650/2012
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 Detection of mutation and epigenetic alterations in blood cell-free DNA
38704/ADI/QREN
Principal investigator
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Agência Nacional de Inovação SA
Concluded
2009/01 - 2012/06 Vitamin D, a candidate for new therapy of basal-like breast carcinomas
Provided by PTCRIS: 83264
Researcher
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Journal article
  1. JA Freitas; Irene Gullo; Diogo Garcia; Sara Miranda; Louisa Spaans; Lídia Pinho; Joana Pereira Reis; et al. "The Adaptive Immune Landscape of the Colorectal Adenoma–Carcinoma Sequence". International Journal of Molecular Sciences (2021): https://www.mdpi.com/1422-0067/22/18/9791.
    10.3390/ijms22189791
  2. Gabriela Fernandes; Catarina Costa Dias de Sousa; Joana Pereira Reis; Natália Cruz-Martins; Conceição Souto Moura; Susana Guimarães; Ana Justino; et al. "Liquid Biopsy for Disease Monitoring in Non-Small Cell Lung Cancer: The Link between Biology and the Clinic". Cells (2021): https://www.mdpi.com/2073-4409/10/8/1912.
    10.3390/cells10081912
  3. T. Pereira; Joana Morgado; Francisco Silva; Michele M. Pelter; Vasco Rosa Dias; Rita Barros; Claudia Freitas; et al. "Sharing Biomedical Data: Strengthening AI Development in Healthcare". Healthcare (2021): https://www.mdpi.com/2227-9032/9/7/827.
    10.3390/healthcare9070827
  4. Gabriela Fernandes; Natália Cruz-Martins; Conceição Souto Moura; Susana Guimarães; Joana Pereira Reis; Ana Justino; Maria João Pina; et al. "Clinical Application of Next-Generation Sequencing of Plasma Cell-Free DNA for Genotyping Untreated Advanced Non-Small Cell Lung Cancer". Cancers (2021): https://www.mdpi.com/2072-6694/13/11/2707.
    10.3390/cancers13112707
  5. Joana B. Loureiro; Liliana Raimundo; Juliana Calheiros; Carla Carvalho; Valentina Barcherini; Nuno R. Lima; Célia Gomes; et al. "Targeting p53 for Melanoma Treatment: Counteracting Tumour Proliferation, Dissemination and Therapeutic Resistance". Cancers 13 7 (2021): 1648-1648. https://doi.org/10.3390/cancers13071648.
    10.3390/cancers13071648
  6. Joana Morgado; T. Pereira; Francisco Silva; Claudia Freitas; Eduardo Negrão; Beatriz Flor de Lima; Miguel Correia da Silva; et al. "Machine Learning and Feature Selection Methods for EGFR Mutation Status Prediction in Lung Cancer". Applied Sciences (2021): https://www.mdpi.com/2076-3417/11/7/3273.
    10.3390/app11073273
  7. Tania Pereira; Cláudia Freitas; José Luis Costa; Joana Morgado; Francisco Silva; Eduardo Negrão; Beatriz Flor de Lima; et al. "Comprehensive Perspective for Lung Cancer Characterisation Based on AI Solutions Using CT Images". Journal of Clinical Medicine 10 1 (2020): 118-118. https://doi.org/10.3390/jcm10010118.
    10.3390/jcm10010118
  8. Alexandra Mesquita; José Luís Costa; Fernando Schmitt. "Utility of Circulating Tumor DNA in Different Clinical Scenarios of Breast Cancer". Cancers (2020): https://doi.org/10.3390/cancers12123797.
    10.3390/cancers12123797
  9. Francisco Silva; Tania Pereira; Julieta Frade; José Mendes; Claudia Freitas; Venceslau Hespanhol; José Luis Costa; António Cunha; Hélder P. Oliveira. "Pre-Training Autoencoder for Lung Nodule Malignancy Assessment Using CT Images". Applied Sciences (2020): https://doi.org/10.3390/app10217837.
    10.3390/app10217837
  10. Costa, José Luis. "Identifying relationships between imaging phenotypes and lung cancer-related mutation status: EGFR and KRAS". Scientific Reports (2020): http://dx.doi.org/10.1038/s41598-020-60202-3.
    10.1038/s41598-020-60202-3
  11. Marques, J.F.; Junqueira-Neto, S.; Pinheiro, J.; Machado, J.C.; Costa, J.L.. "Induction of apoptosis increases sensitivity to detect cancer mutations in plasma". European Journal of Cancer 127 (2020): 130-138. http://www.scopus.com/inward/record.url?eid=2-s2.0-85078673234&partnerID=MN8TOARS.
    10.1016/j.ejca.2019.12.023
  12. Junqueira-Neto, S.; Batista, I.A.; Costa, J.L.; Melo, S.A.. "Liquid Biopsy beyond Circulating Tumor Cells and Cell-Free DNA". Acta Cytologica 63 6 (2019): 479-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-85062083142&partnerID=MN8TOARS.
    10.1159/000493969
  13. Costa, J.L.; Schmitt, F.C.. "Liquid Biopsy: A New Tool in Oncology". Acta Cytologica 63 6 (2019): 448-448. http://www.scopus.com/inward/record.url?eid=2-s2.0-85068508309&partnerID=MN8TOARS.
    10.1159/000501355
  14. Fernandes Marques, J.; Pereira Reis, J.; Fernandes, G.; Hespanhol, V.; Machado, J.C.; Costa, J.L.. "Circulating Tumor DNA: A Step into the Future of Cancer Management". Acta Cytologica 63 6 (2019): 456-465. http://www.scopus.com/inward/record.url?eid=2-s2.0-85063397980&partnerID=MN8TOARS.
    10.1159/000492917
  15. Fernandes, M.G.O.; Jacob, M.; Martins, N.; Moura, C.S.; Guimarães, S.; Reis, J.P.; Justino, A.; et al. "Targeted gene next-generation sequencing panel in patients with advanced lung adenocarcinoma: Paving the way for clinical implementation". Cancers 11 9 (2019): http://www.scopus.com/inward/record.url?eid=2-s2.0-85071868403&partnerID=MN8TOARS.
    10.3390/cancers11091229
  16. Cecily P. Vaughn; José Luis Costa; Harriet E. Feilotter; Rosella Petraroli; Varun Bagai; Anna Maria Rachiglio; Federica Zito Marino; et al. "Simultaneous detection of lung fusions using a multiplex RT-PCR next generation sequencing-based approach: a multi-institutional research study". BMC Cancer (2018): https://doi.org/10.1186/s12885-018-4736-4.
    10.1186/s12885-018-4736-4
  17. Prieto-Potin, I.; Montagut, C.; Bellosillo, B.; Evans, M.; Smith, M.; Melchior, L.; Reiltin, W.; et al. "Multicenter Evaluation of the Idylla NRAS-BRAF Mutation Test in Metastatic Colorectal Cancer". Journal of Molecular Diagnostics 20 5 (2018): 664-676. http://www.scopus.com/inward/record.url?eid=2-s2.0-85051652688&partnerID=MN8TOARS.
    10.1016/j.jmoldx.2018.05.008
  18. Ferreira, R.M.; Pereira-Marques, J.; Pinto-Ribeiro, I.; Costa, J.L.; Carneiro, F.; MacHado, J.C.; Figueiredo, C.. "Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota". Gut 67 2 (2018): 226-236. http://www.scopus.com/inward/record.url?eid=2-s2.0-85043251326&partnerID=MN8TOARS.
    10.1136/gutjnl-2017-314205
  19. Da Cruz Paula, A.; Leitão, C.; Marques, O.; Rosa, A.M.; Santos, A.H.; Rêma, A.; de Fátima Faria, M.; et al. "Molecular characterization of CD44+/CD24-/Ck+/CD45-cells in benign and malignant breast lesions". Virchows Archiv 470 3 (2017): 311-322. http://www.scopus.com/inward/record.url?eid=2-s2.0-85010782778&partnerID=MN8TOARS.
    10.1007/s00428-017-2068-4
  20. Deans, Z.C.; Costa, J.L.; Cree, I.; Dequeker, E.; Edsjö, A.; Henderson, S.; Hummel, M.; et al. "Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL". Virchows Archiv 470 1 (2017): 5-20. http://www.scopus.com/inward/record.url?eid=2-s2.0-84988683702&partnerID=MN8TOARS.
    10.1007/s00428-016-2025-7
  21. Oliveira, J.; Gonçalves, A.; Taipa, R.; Melo-Pires, M.; Oliveira, M.E.; Costa, J.L.; Machado, J.C.; et al. "New massive parallel sequencing approach improves the genetic characterization of congenital myopathies". Journal of Human Genetics 61 6 (2016): 497-505. http://www.scopus.com/inward/record.url?eid=2-s2.0-84976533750&partnerID=MN8TOARS.
    10.1038/jhg.2016.2
  22. Barranha, R.; Costa, J.L.; Carneiro, F.; Machado, J.C.. "Genetic heterogeneity in colorectal cancer and its clinical implications,Heterogeneidade genética no cancro colorrectal e as suas implicações clínicas". Acta Medica Portuguesa 28 3 (2015): 370-375. http://www.scopus.com/inward/record.url?eid=2-s2.0-84936944622&partnerID=MN8TOARS.
  23. Castro, L.; Alves, S.; Chaves, S.R.; Costa, J.L.; Soares, P.; Preto, A.. "RAF-1 promotes survival of thyroid cancer cells harboring RET/PTC1 rearrangement independently of ERK activation". Molecular and Cellular Endocrinology 415 (2015): 64-75. http://www.scopus.com/inward/record.url?eid=2-s2.0-84942832084&partnerID=MN8TOARS.
    10.1016/j.mce.2015.08.006
  24. Vissers, L.E.L.M.; Bonetti, M.; Paardekooper Overman, J.; Nillesen, W.M.; Frints, S.G.M.; De Ligt, J.; Zampino, G.; et al. "Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome". European Journal of Human Genetics 23 3 (2015): 317-324. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938421325&partnerID=MN8TOARS.
    10.1038/ejhg.2014.115
  25. Justino, A.; Dias, P.; João Pina, M.; Sousa, S.; Cirnes, L.; Berta Sousa, A.; Carlos Machado, J.; Costa, J.L.. "Comprehensive massive parallel DNA sequencing strategy for the genetic diagnosis of the neuro-cardio-facio-cutaneous syndromes". European Journal of Human Genetics 23 3 (2015): 347-353. http://www.scopus.com/inward/record.url?eid=2-s2.0-84938422130&partnerID=MN8TOARS.
    10.1038/ejhg.2014.97
  26. Vranic, S.; Schmitt, F.; Sapino, A.; Costa, J.L.; Reddy, S.; Castro, M.; Gatalica, Z.. "Apocrine carcinoma of the breast: A comprehensive review". Histology and Histopathology 28 11 (2013): 1393-1409. http://www.scopus.com/inward/record.url?eid=2-s2.0-84886296225&partnerID=MN8TOARS.
  27. Di Lorito, A.; Rosini, S.; Falò, E.; Gustapane, S.; Gomes, M.; Costa, J.L.; Schmitt, F.C.. "Molecular alterations in endometrial archived liquid-based cytology". Diagnostic Cytopathology 41 6 (2013): 492-496. http://www.scopus.com/inward/record.url?eid=2-s2.0-84878020013&partnerID=MN8TOARS.
    10.1002/dc.22869
  28. Costa, J.L.; Sousa, S.; Justino, A.; Kay, T.; Fernandes, S.; Cirnes, L.; Schmitt, F.; Machado, J.C.. "Nonoptical Massive Parallel DNA Sequencing of BRCA1 and BRCA2 Genes in a Diagnostic Setting". Human Mutation 34 4 (2013): 629-635. http://www.scopus.com/inward/record.url?eid=2-s2.0-84875519657&partnerID=MN8TOARS.
    10.1002/humu.22272
  29. Lopes, N.; Carvalho, J.; Durães, C.; Sousa, B.; Gomes, M.; Costa, J.L.; Oliveira, C.; Paredes, J.; Schmitt, F.. "1Alpha,25-dihydroxyvitamin D3induces de novo E-cadherin expression in triple-negative breast cancer cells by CDH1-promoter demethylation". Anticancer Research 32 1 PART 2 (2012): 249-257. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856024024&partnerID=MN8TOARS.
  30. Lopes, N.; Paredes, J.; Costa, J.L.; Ylstra, B.; Schmitt, F.. "Vitamin D and the mammary gland: A review on its role in normal development and breast cancer". Breast Cancer Research 14 3 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84861982740&partnerID=MN8TOARS.
    10.1186/bcr3178
  31. Gerhard, R.; Costa, J.L.; Schmitt, F.. "Benign and malignant apocrine lesions of the breast". Expert Review of Anticancer Therapy 12 2 (2012): 215-221. http://www.scopus.com/inward/record.url?eid=2-s2.0-84856849698&partnerID=MN8TOARS.
    10.1586/era.11.213
  32. Sousa, B.; Paredes, J.; Milanezi, F.; Lopes, N.; Martins, D.; Dufloth, R.; Vieira, D.; et al. "P-cadherin, Vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: An immunohistochemical study". Histology and Histopathology 25 8 (2010): 963-974. http://www.scopus.com/inward/record.url?eid=2-s2.0-77956895496&partnerID=MN8TOARS.
  33. Lopes, N.; Sousa, B.; Martins, D.; Gomes, M.; Vieira, D.; Veronese, L.A.; Milanezi, F.; et al. "Alterations in Vitamin D signalling and metabolic pathways in breast cancer progression: A study of VDR, CYP27B1 and CYP24A1 expression in benign and malignant breast lesions Vitamin D pathways unbalanced in breast lesions". BMC Cancer 10 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77956478256&partnerID=MN8TOARS.
    10.1186/1471-2407-10-483
  34. Carvalho, S.; Milanezi, F.; Costa, J.L.; Amendoeira, I.; Schmitt, F.. "PIKing the right isoform: The emergent role of the p110ß subunit in breast cancer". Virchows Archiv 456 3 (2010): 235-243. http://www.scopus.com/inward/record.url?eid=2-s2.0-77949716267&partnerID=MN8TOARS.
    10.1007/s00428-010-0881-0
  35. Costa, J.L.; Eijk, P.P.; van de Wiel, M.A.; ten Berge, D.; Schmitt, F.; Narvaez, C.J.; Welsh, J.; Ylstra, B.. "Anti-proliferative action of vitamin D in MCF7 is still active after siRNA-VDR knock-down". BMC Genomics 10 (2009): http://www.scopus.com/inward/record.url?eid=2-s2.0-70749144760&partnerID=MN8TOARS.
    10.1186/1471-2164-10-499
  36. Elhai, J.; Kato, M.; Cousins, S.; Lindblad, P.; Costa, J.L.. "Very small mobile repeated elements in cyanobacterial genomes". Genome Research 18 9 (2008): 1484-1499. http://www.scopus.com/inward/record.url?eid=2-s2.0-50649084154&partnerID=MN8TOARS.
    10.1101/gr.074336.107
  37. Costa, J.L.; Meijer, G.; Ylstra, B.; Caldas, C.. "Array Comparative Genomic Hybridization Copy Number Profiling: A New Tool for Translational Research in Solid Malignancies". Seminars in Radiation Oncology 18 2 (2008): 98-104. http://www.scopus.com/inward/record.url?eid=2-s2.0-39749145837&partnerID=MN8TOARS.
    10.1016/j.semradonc.2007.10.005
  38. Chin, S.F.; Teschendorff, A.E.; Marioni, J.C.; Wang, Y.; Barbosa-Morais, N.L.; Thorne, N.P.; Costa, J.L.; et al. "High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer". Genome Biology 8 10 (2007): http://www.scopus.com/inward/record.url?eid=2-s2.0-39749108733&partnerID=MN8TOARS.
    10.1186/gb-2007-8-10-r215
  39. Van De Wiel, M.A.; Costa, J.L.; Smid, K.; Oudejans, C.B.M.; Bergman, A.M.; Meijer, G.A.; Peters, G.J.; Ylstra, B.. "Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations". Cancer Research 65 22 (2005): 10208-10213. http://www.scopus.com/inward/record.url?eid=2-s2.0-27144454948&partnerID=MN8TOARS.
    10.1158/0008-5472.CAN-05-0760
  40. Costa, J.-L.; Romero, E.M.; Lindblad, P.. "Sequence based data supports a single Nostoc strain in individual coralloid roots of cycads". FEMS Microbiology Ecology 49 3 (2004): 481-487. http://www.scopus.com/inward/record.url?eid=2-s2.0-4344572983&partnerID=MN8TOARS.
    10.1016/j.femsec.2004.05.001
  41. Costa, J.-L.; Paulsrud, P.; Lindblad, P.. "The cyanobacterial tRNALeu (UAA) intron: Evolutionary patterns in a genetic marker". Molecular Biology and Evolution 19 6 (2002): 850-857. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036275713&partnerID=MN8TOARS.
    10.1093/oxfordjournals.molbev.a004142
  42. Lindblad, P.; Costa, J.-L.. "The cyanobacterial - Cycad symbiosis". Biology and Environment 102 1 (2002): 31-33. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036743003&partnerID=MN8TOARS.
    10.3318/BIOE.2002.102.1.31
  43. Costa, J.-L.; Paulsrud, P.; Rikkinen, J.; Lindblad, P.. "Genetic Diversity of Nostoc Symbionts Endophytically Associated with Two Bryophyte Species". Applied and Environmental Microbiology 67 9 (2001): 4393-4396. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035458439&partnerID=MN8TOARS.
    10.1128/AEM.67.9.4393-4396.2001
  44. Tamagnini, P.; Costa, J.-L.; Almeida, L.; Oliveira, M.-J.; Salema, R.; Lindblad, P.. "Diversity of cyanobacterial hydrogenases, a molecular approach". Current Microbiology 40 6 (2000): 356-361. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034034712&partnerID=MN8TOARS.
  45. Costa, J.-L.; Paulsrud, P.; Lindblad, P.. "Cyanobiont diversity within coralloid roots of selected cycad species". FEMS Microbiology Ecology 28 1 (1999): 85-91. http://www.scopus.com/inward/record.url?eid=2-s2.0-0032947669&partnerID=MN8TOARS.
    10.1016/S0168-6496(98)00095-6

Intellectual property

Patent
  1. Costa, José Luis. 2018. "Microbiome Markers for Gastric Cancer".
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2017 - Current Horizontal transmission of therapy resistance in cancer: a role for tumor-derived exosomes
Supervisor
 Biomedicina (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2017 - Current PiggyBac transposon-based genetic screening in mice to uncover molecular networks of Braf V600E-induced intestinal tumourigenesis
Co-supervisor
 Biologia Básica e Aplicada (PhD)
Universidade do Porto Faculdade de Medicina, Portugal
2016 - Current Exploring BRCA1 in cancer: from prevention to new therapeutic opportunities
Co-supervisor
 Biotecnologia Molecular e Celular Aplicada às Ciências da Saúde (PhD)
Universidade do Porto, Portugal
2017/09/15 - 2018/12/11 Gene rearrangments in lung cancer: towards the detection in cell free nucleic acids
Supervisor
 Medicina e Oncologia Molecular
Universidade do Porto Faculdade de Medicina, Portugal
2016 - 2017 Breaking the ctDNA sensitivity barrier
Supervisor
 Biologia Celular e Molecular (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
2015 - 2015 A Bayesian hierarchical robust model to detect and identify exonic CNVs Engenharia Matemática (Master)
Universidade do Porto Faculdade de Ciências, Portugal
2011 - 2012 Diagnóstico Genético das sindromes associadas à via de sinalização RAS/MAPK através de sequenciação paralela massiva e estudo de correlações genótipo-fenótipo
Co-supervisor
 Medicina e Oncologia Molecular (Master)
Universidade do Porto Faculdade de Medicina, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2018 Early detection of the three major primary cancers in women by cell-free DNA methylation in liquid biopsies
(Thesis) Main arguer
 Sandra Isabel Pinto Nunes (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 Circulating MicroRNAs as Markers of Prostate Cancer Progression: a Time-based Approach
(Thesis) Main arguer
 David Bidarra de Castro Pinto (Master)
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal
2017 Breaking the ctDNA sensitivity barrier
Supervisor
 Joana Rita Fernandes Marques (Master)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
Distinctions

Award

2018 Prémio Pfizer de Investigação Clinica
Pfizer Portugal, Portugal
2001 The Royal Swedish Academy of Sciences
Kungliga Vetenskapsakademien, Sweden

Other distinction

2007 Bolsa de Investigação ’07
Sociedade Portuguesa de Oncologia, Portugal

Sociedade Portuguesa de Senologia, Portugal