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Joana Filipa Melfe Tomás. É Investigador no(a) Universidade da Beira Centro de Investigação em Ciências da Saúde. Publicou 8 artigos em revistas especializadas. Nas suas atividades profissionais interagiu com 48 colaborador(es) em coautorias de trabalhos científicos. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Cerebrospinal fluid; Choroid plexus; Odorant receptors; Olfactory; Polyamines; Receptor de androgénio; DNA; .
Identification

Personal identification

Full name
Joana Filipa Melfe Tomás

Citation names

  • Tomás, Joana

Author identifiers

Ciência ID
F51D-5365-D95D
ORCID iD
0000-0001-8796-5152

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Education
Degree Classification
2023/10/12 - 2023/10/12
Concluded
 Gestão de resíduos hospitalares e resíduos líquidos Perigosos (Outros)
Universidade da Beira Interior, Portugal

Ambimed – Gestão Ambiental, Lda. , Portugal
2021/06/15 - 2021/07/08
Concluded
 Introdução à utilização e proteção dos dados pessoais (Outros)
Universidade da Beira Interior Centro de Formação Interação UBI Tecido Empresarial, Portugal

Assosiação Empresarial da Covilhã, Belmonte e Penamacor - AECBP, Portugal
2011/09/15 - 2020/05/13
Concluded
 Biomedicina (Doutoramento)
Major in Neurociencias
Universidade da Beira Interior, Portugal
2015/04 - 2015/04
Concluded
 Nucleic Acids Sequencing and Analysis, A theorical & hands-on course (Outros)
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015/01 - 2015/02
Concluded
 II PERSONAL TRAINING COURSE FOR BIOMEDICAL RESEARCHERS IN SCIENCE AND USERS OF EXPERIMENTAL ANIMALS. CATEGORY C (Outros)
Minimal Invasive Surgery Centre "Jesus Usón", Spain
2013/11 - 2013/11
Concluded
 I Hands-on Course on Fluorescence Microscopy and Image Analysis (Outros)
Major in Microscopy
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2007/10/01 - 2008/09/30
Concluded
 Bioquímica (Mestrado integrado)
Universidade da Beira Interior, Portugal
"Androgen receptor alternative spliced transcrips: tissue expression and evolutionary analysis" (THESIS/DISSERTATION)
 17
2008/02 - 2008/06
Concluded
 Technology Based Entrepreneurship Course - 30h course (Outros)
Universidade da Beira Interior, Portugal

Universidade de Coimbra, Portugal

Universidade de Aveiro, Portugal
2002/10/01 - 2007/09/30
Concluded
 Bioquímica (Licenciatura)
Universidade da Beira Interior, Portugal
"Dirrect Effects of Anti-cancer Drugs and Endocrine Disruptors on Gene Expression of Several Genes in Spermatogonia Stem Cells; University of Beira Interior and Utrecht university" (THESIS/DISSERTATION)
 14
Affiliation

Science

Category
Host institution 		Employer
2011/09/13 - 2020/05/13 Researcher (Research) Universidade da Beira Interior, Portugal
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal

Other Careers

Category
Host institution 		Employer
2019/06/03 - Current Assistente Técnico (Assistente Técnico) Universidade da Beira Interior, Portugal
Universidade da Beira Interior, Portugal

Others

Category
Host institution 		Employer
2010/12 - 2011/04 Trainner of Food Safety and Hygiene Instituto Politécnico da Guarda Escola Superior de Turismo e Hotelaria, Portugal
2009/12 - 2010/07 Trainner of Biology, Anatomy and Pysico-chemical Belalbi, Formação e serviços, LDA, Portugal
2009/07 - 2009/09 Microbiology laboratory analyst FIT – Fomento da Industria do Tomate, , Portugal
Projects

Grant

Designation Funders
2019/02/25 - 2020/06/02 Desafios interdisciplinares em Neurodegeneração (ICON)”
CENTRO-01 -0145-FEDER-000013
Research Fellow
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
Ongoing
2016/08 - 2018/02 Relationship between adenosine and chromosomal instability: a new perspective to understand the oncogenic mechanism in glioblastoma
PTDC/BIM-ONC/7121/2014
 Fundação para a Ciencia e Tecnologia / FEDER
2013/03 - 2015/05 Hormonal and Inflammatory basis of age-related diseases
CENTRO-07-ST24-FEDER-002015; HIB 2-001
 QREN
Outputs

Publications

Book chapter
  1. Gonçalves, Isabel; Quintela, Telma; Duarte, Ana Catarina; Hubbard, Peter; Baltazar, Graça; Schwerk, Christian; Belin, Andrea Carmine; Tomás, Joana; Santos, Cecília Reis A.. "Experimental Tools to Study the Regulation and Function of the Choroid Plexus". In Blood-Brain Barrier, 205-230. Springer New York, 2018.
    Published • 10.1007/978-1-4939-8946-1_13
Conference poster
  1. Costa, A; Gonçalves I; Cascalheira, JF; Duarte AC; Tomás, Joana; Santos CRA. "Bitter taste signaling in glioblastoma". Paper presented in 11th FENS Forum of Neuroscience, 2018.
  2. Tomás, Joana. "Bitter taste signaling in glioblastoma". Paper presented in XIII Annual CICS-UBI Symposium. Covilhã Julho 2018, 2018.
  3. De, Rajat; Nayak, Losiana. "Unveiling the chemosensing mechanosms at the brain barriers: taste and olfactory signaling pathways". Paper presented in XIII Annual CICS-UBI Symposium. Covilhã Julho 2018, 2017.
  4. Ravindran, K.; Rabby, M.. "The senses of the choroid plexos: unveiling the mechanisms of chemical surveillance at brain barriers.". Paper presented in Encontro com a Ciência e Tecnologia em Portugal. Centro de Congressos de Lisboa. Lisboa 4-6 de Junho 2016, 2016.
  5. Tomás, Joana. "Intra and Extracellular pre-miR-29b purification by an arginine monolithic support.". Paper presented in XVI Congresso Latino-Americano de Cromatografia (XVI COLACRO). Lisboa, Portugal 2016, 2016.
  6. Tomás, Joana. "Implementation of biotechnological platform to obtain a HPV-16 E6 and E7 plasmid DNA vaccine.". Paper presented in I Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Endocrinology and Neurosciences. Covilhã, Portugal 2015, 2015.
  7. Tomás, Joana. "Estradiol and bisphenol-A regulation of the taste transduction pathway in rat choroid plexus". Paper presented in X Annual CICS Symposium. Covilhã Julho 2015, 2015.
  8. Tomás, Joana. "Polyplexes-mediated delivery of pre-miR-29b for Alzheimer’s disease therapeutics.". Paper presented in I Congress in Health Sciences Research: Towards Innovation and Entrepreneurship Trends in Endocrinology and Neurosciences. Covilhã, Portugal 2015, 2015.
  9. Tomás, Joana. "Biotechnological approach to prepare a DNA vaccine for HPV induced-cervical cancer treatment". Paper presented in 30th International Papillomavirus Conference. Lisboa, Portugal 2015, 2015.
  10. Tomás, Joana. "Does choroid plexos can smell?". Paper presented in VII Annual CICS Symposium, Covilhã Julho 2012, 2012.
  11. Tomás, Joana. "Splice Variants for the Androgen Receptor in Testis of Vertebrates.". Paper presented in 17th European Workshop on Molecular and Cellular Endocrinology of the Testis. Stockholm, Sweden April 2012, 2012.
Journal article
  1. Susana Ferreira, Ana L. Silva, Joana Tomás, Cristiana Mateus, Fernanda Domingues, Mónica Oleastro. "Characterization of AreABC, an RND-Type Efflux System Involved in Antimicrobial Resistance of Aliarcobacter butzleri". Antimicrobial Agents and Chemotherapy 65 9 (2021): http://dx.doi.org/10.1128/aac.00729-21.
    10.1128/aac.00729-21
  2. Daniela Talhada; Ana Raquel Costa-Brito; Ana Catarina Duarte; Ana Raquel Costa; Telma Quintela; Joana Tomás; Isabel Gonçalves; Cecília Reis Alves Santos. "The choroid plexus: Simple structure, complex functions". Journal of Neuroscience Research (2019): https://doi.org/10.1002/jnr.24571.
    10.1002/jnr.24571
  3. Joana Tomás; Cecília R.A. Santos; Ana C. Duarte; Maria Maltez; Telma Quintela; Manuel C. Lemos; Isabel Gonçalves. "Bitter taste signaling mediated by Tas2r144 is down-regulated by 17ß-estradiol and progesterone in the rat choroid plexus". Molecular and Cellular Endocrinology 495 (2019): 110521-110521. https://doi.org/10.1016/j.mce.2019.110521.
    10.1016/j.mce.2019.110521
  4. Helena Marcelino; Vanda C. Nogueira; Cecília R.A. Santos; Patrícia Quelhas; Tiago M.A. Carvalho; João Fonseca-Gomes; Joana Tomás; et al. "Adenosine inhibits human astrocyte proliferation independently of adenosine receptor activation". Journal of Neurochemistry (2019): https://doi.org/10.1111%2Fjnc.14937.
    10.1111/jnc.14937
  5. Almeida, A.M.; Tomás, J.; Pereira, P.; Queiroz, J.A.; Sousa, F.; Sousa, Â.. "HPV-16 targeted DNA vaccine expression: The role of purification". Biotechnology Progress 34 2 (2018): 546-551. http://www.scopus.com/inward/record.url?eid=2-s2.0-85040709703&partnerID=MN8TOARS.
    10.1002/btpr.2603
  6. Santos, C.R.A.; Duarte, A.C.; Quintela, T.; Tomás, J.; Albuquerque, T.; Marques, F.; Palha, J.A.; Gonçalves, I.. "The choroid plexus as a sex hormone target: Functional implications". Frontiers in Neuroendocrinology 44 (2017): 103-121. http://www.scopus.com/inward/record.url?eid=2-s2.0-85008324860&partnerID=MN8TOARS.
    10.1016/j.yfrne.2016.12.002
  7. Costa AR; Marcelino H; Gonçalves I; Quintela T; Tomás J; Duarte AC; Fonseca AM; Santos CR. "Sex hormones protect against amyloid-beta induced oxidative stress in the choroid plexus cell line Z310.". (2016): http://europepmc.org/abstract/med/27328988.
    10.1111/jne.12404
  8. Gonçalves I; Hubbard PC; Tomás J; Quintela T; Tavares G; Caria S; Barreiros D; R A Santos C. ""Smelling" the cerebrospinal fluid: Olfactory signaling molecules are expressed in and mediate chemosensory signaling from the choroid plexus.". (2016): http://europepmc.org/abstract/med/26934374.
    10.1111/febs.13700
  9. Tomás, J.; Santos, C.R.A.; Quintela, T.; Gonçalves, I.. ""Tasting" the cerebrospinal fluid: Another function of the choroid plexus?". Neuroscience 320 (2016): 160-171. http://www.scopus.com/inward/record.url?eid=2-s2.0-84958260325&partnerID=MN8TOARS.
    10.1016/j.neuroscience.2016.01.057
  10. Pereira, P.; Pedro, A.Q.; Tomás, J.; Maia, C.J.; Queiroz, J.A.; Figueiras, A.; Sousa, F.. "Advances in time course extracellular production of human pre-miR-29b from Rhodovulum sulfidophilum". Applied Microbiology and Biotechnology 100 8 (2016): 3723-3734. http://www.scopus.com/inward/record.url?eid=2-s2.0-84957660777&partnerID=MN8TOARS.
    10.1007/s00253-016-7350-x
  11. Pereira, P.A.; Tomás, J.F.; Queiroz, J.A.; Figueiras, A.R.; Sousa, F.. "Recombinant pre-miR-29b for Alzheimer's disease therapeutics". Scientific Reports 6 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84955595017&partnerID=MN8TOARS.
    10.1038/srep19946
  12. Laurentino, S.S.; Pinto, P.I.S.; Tomás, J.; Cavaco, J.E.; Sousa, M.; Barros, A.; Power, D.M.; Canário, A.V.M.; Socorro, S.. "Identification of androgen receptor variants in testis from humans and other vertebrates". Andrologia 45 3 (2013): 187-194. http://www.scopus.com/inward/record.url?eid=2-s2.0-84876814362&partnerID=MN8TOARS.
    10.1111/j.1439-0272.2012.01333.x
Thesis / Dissertation
  1. Tomás, Joana Filipa Melfe. "Androgen receptor alternative spliced transcripts: tissue expression and evolutionary analysis". Master, 2008. http://hdl.handle.net/10400.6/2777.
  2. Tomás, Joana. "Dirrect Effects of Anti-cancer Drugs and Endocrine Disruptors on Gene Expression of Several Genes in Spermatogonia Stem Cells". Degree, Universidade da Beira Interior Faculdade de Ciências, 2007.
Activities

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2014/09/01 - 2015/09/30 Effect of the endocrin disruptor BPA in the taste patway in the choroid plexus
Co-supervisor
 Bioquímica (Master)
Universidade da Beira Interior, Portugal
2013/09/01 - 2014/09/30 Neuroinflamação e neurogénese no plexo coróide
Co-supervisor
 Ciências Biomédicas (Master)
Universidade da Beira Interior, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2014/02/21 - 2015/11/28 Organization of the International Congress in Health Sciences Research Towards Innovation and Entrepreneurship (2015/11/26 - 2015/11/28)
Congress (Co-organisor)
 Universidade da Beira Interior Faculdade de Ciências da Saúde, Portugal

Other jury / evaluation

Activity description Institution / Organization
2015 - 2015 Examiner of 1st Cycle in Biotechnology Project - Marina Bonifácio, “Papel de adesinas nos mecanismos de patogenicidade de Arcobacter butzleri” Universidade da Beira Interior, Portugal
Distinctions

Award

2016 Selected paper - World Biomedical Frontiers, Neuroscience (ISSN: 2328-0166)
2015 Best poster presentation
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015 Best oral commmunication
Universidade da Beira Interior Centro de Investigação em Ciências da Saúde, Portugal
2015 Best oral communication
Instituto Politécnico da Guarda Escola Superior de Saúde, Portugal