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Rita Caridade Silva graduated in Applied Biology at the University of Minho in 2019. During this time, she has performed a bachelor's internship project in the field of oncology, studying the biological effect of RKIP expression in lung adenocarcinoma at the Life and Health Sciences Research Institute (ICVS). In this work, she had the chance to learn and develop a multidisciplinary technical profile, including cell culture techniques, western blot, cell viability, proliferation assays, and cell migration studies (wound-healing assay). After that, from 2019 to 2021, she enrolled in the Master's program in Health Sciences at the Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho. At the end of 2019, she did a laboratory rotation in the Neurosciences Research Domain (ICVS) under the supervision of Dr. Fábio Teixeira, exploring the combinatorial potential of stem cells secretome (SCS) and Safinamide for Parkinson's disease (PD) treatment. Following this, at the beginning of 2020, she received appropriate training in laboratory animal science by attending a course that follows the Federation for European Laboratory Animal Sciences Associations (FELASA) recommendations (category C), which currently allows her to work with laboratory animals for research purposes. In 2021, she completed her MSc dissertation entitled "Combining Stem Cells Secretome (SCS) and N-acetylcysteine (NAC) to Parkinson's Disease modeling and repair" under Dr. Fábio Teixeira and Dr. António Salgado's supervision. Her research work focused on the development of a novel combinatorial therapeutic strategy for PD modeling and repair, using a stem cell-free-based approach and a potential neuroprotective PD drug. The results found NAC as modulators of brain repair, given its capacity to promote neuroprotection and signaling pathways modulation, thereby contributing to dopaminergic integrity preservation. From January 2022 to December 2022, she joined Dr. Fábio Teixeira's group as a research fellow under the project entitled "Focused Ultrasound combined with Stem Cells Secretome and Pharmacotherapies: establishing a Multimodal path for Parkinson's disease repair" exploring the impact of combinatory multimodal drugs and magnetic resonance (MRI)-guided focused ultrasound (FUS) on blood-brain barrier transient openings to the precise delivery of pharmacological strategies in Parkinson's disease-affected brain areas. Accordingly, she undertook a 4-month lab rotation at NeuroSpin (France), acquiring skills in MRI-guided focused ultrasound (FUS) and combined drug delivery techniques for Parkinson's disease. Currently, she is a PhD student in the Biomedicine doctoral program at the Faculty of Medicine (FMUP), University of Porto. She began her PhD scholarship funded by FCT in January 2023, and is now focusing on her PhD project titled "Repurposing Multimodal Strategies for Parkinson’s Disease: Creating the Path for Disease Delay and Repair." Her research interests lie in discovering innovative treatment approaches for Parkinson's Disease. Throughout her dedicated work, she successfully published a total of five papers in peer-reviewed journals, with two of them as a first author (including a literature review and a results paper). Additionally, she presented her research at various international conferences such as ENCODS (awarded for poster presentation), AD/PD22 (oral presentation), IBRO (poster presentation), and AD/PD24 (poster presentation), along with a national presentation and pitch poster presentation. Recently, she received the PAPRE Prize (Programme of Support for Publication in High-Quality Scientific Journals) from the Porto Polytechnic Institute and a Travel Grant from the Portuguese Society for Neuroscience (SPN).
Identification

Personal identification

Full name
Rita Caridade Silva
Date of birth
1998/03/15
Gender
Female

Citation names

  • Caridade-Silva, Rita
  • Silva, Rita Caridade

Author identifiers

Ciência ID
F51E-0A89-D85B
ORCID iD
0000-0003-4819-6359
Scopus Author Id
57896788900

Email addresses

  • rcaridade@i3s.up.pt (Professional)
  • ritacaridade@hotmail.com (Personal)

Addresses

  • i3S - Instituto de Investigação e Inovação em Saúde, 4200-135 , Porto, Porto, Portugal (Professional)

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences - Health Sciences
  • Natural sciences - Biological Sciences - Biology

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese (Mother tongue)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Education
Degree Classification
2022/09/09 - 2026
Ongoing
Doctoral Programme in Biomedicine (Doutoramento)
Universidade do Porto Faculdade de Medicina, Portugal
2023/12/04 - 2023/12/05
Concluded
Workshop on Scientific Writing: How to streamline the process of writing a scientific paper (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/11/06 - 2023/11/08
Concluded
3D microscopy imaging with clearness | 1st edition (Outros)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/06 - 2023/06
Concluded
Laboratory Rotation (Outros)
Major in Neuroimaging and Neurodegenerative disorders
Commissariat à l'Énergie Atomique et aux Énergies Alternatives NeuroSpin, France
18
2022/09/26 - 2022/09/30
Concluded
Introduction to Digital BioImage Analysis | 4th Edition (Outros)
Major in Digital BioImage Analysis
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2022/01 - 2022/07
Concluded
Specialized Training Course in Fundamentals for Scientific Research (Outros)
Universidade do Minho, Portugal
Approved
2019/09/11 - 2021/11/01
Concluded
Master in Health Sciences (Mestrado)
Major in Neurosciences
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Laboratório Associado ICVS 3B's, Portugal
"Combining Stem Cells Secretome and N-acetylcysteine to Parkinson's Disease modeling and repair" (THESIS/DISSERTATION)
Thesis: 19; Master's degree: 18 (ou of 20)
2019/11 - 2020/05
Concluded
Laboratory Rotation (Outros)
Major in Regenerative Medicine and Cellular Therapies
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
16
2020/02/10 - 2020/02/28
Concluded
Advanced training: Being a Bio-Entrepreneur (Outros)
Major in Bioentrepreneurship
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
17
2020/01/27 - 2020/02/07
Concluded
Laboratory Animal Science (Outros)
Major in Animals Science
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
17
2016/09/19 - 2019/07/05
Concluded
Applied Biology (Licenciatura)
Major in Life sciences
Universidade do Minho Escola de Ciências, Portugal
"Biological effect of RKIP expression in lung cancer cell lines" (THESIS/DISSERTATION)
16
Affiliation

Science

Category
Host institution
Employer
2022/01/20 - 2022/12/31 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2023/09/25 - 2024/07/31 Invited Assistant (Polytechnic Teacher) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal

Others

Category
Host institution
Employer
2022 - Current Acreditação da Direcção Geral de Alimentação e Veterinária (DGAV) como pessoa competente (investigador) para uso de animais. Direcção-Geral de Alimentação e Veterinária, Portugal
2023/05/08 - 2023/08/10 Internship Commissariat à l'Énergie Atomique et aux Énergies Alternatives NeuroSpin, France
Commissariat à l'Énergie Atomique et aux Énergies Alternatives NeuroSpin, France
Projects

Grant

Designation Funders
2023/01/01 - Current Repurposing multimodal strategies for Parkinson’s Disease: creating the path for disease delay and repair?
2022.13323.BD
PhD Student Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
Outputs

Publications

Book chapter
  1. Araújo, Bruna; Silva, Rita Caridade ; Domingues, Helena S; Salgado, António José; Teixeira, Fábio Gabriel. "Mesenchymal Stem Cells Secretome: a potential biopharmaceutical component to regenerative medicine?". In Hand Book of Stem cells, edited by Prof Kh H Haider. Portugal: Springer Nature, 2022.
    Published • https://doi.org/10.1007/978-981-16-6016-0_46-1
Book review
  1. Araújo, Bruna; Caridade-Silva, Rita; Soares-Guedes, Carla; Martins-Macedo, Joana; Gomes, Eduardo D; Monteiro, Susana; Teixeira, Fábio G. "Neuroinflammation and Parkinson's Disease-From Neurodegeneration to Therapeutic Opportunities". (2022): https://doi.org/10.3390/cells11182908.
    Published • doi.org/10.3390/cells11182908
Conference abstract
  1. Caridade-Silva, Rita; Araújo, Bruna; Campos, Jonas; Domingues, Helena S.; Salgado, António José; Teixeira, Fábio G. "N-acetylcysteine as a Parkinson's disease therapy: creating a strategy for disease modeling and repair". Paper presented in International conference on Alzheimer's and Parkinson's Disease and related neurological disorders, Barcelona, 2022.
Conference poster
  1. Araújo, Bruna; Caridade-Silva, Rita; Svenningsson, Per; Pinto, Luisa; Teixeira, Fábio Gabriel. "Impact of Abrogation of Adult Hippocampal Cytogenesis on Parkinson's Disease Pre-clinical Model". Paper presented in International Conference on Alzheimer's and Parkinson's Diseases and related neurological disorders 2024, 2024.
  2. Caridade-Silva, Rita; Araújo, Bruna; Vilaça- Ferreira, AC.; Fernandes, Hugo; Wade-Martins, Richard; Teixeira, Fábio G. "Multi-targeted strategies to arrest Parkinson’s Disease: the utility of repurposing drugs for neuroprotective approaches". Paper presented in International conference on Alzheimer's and Parkinson's Disease and related neurological disorders (2024), 2024.
  3. Caridade-Silva, Rita; Araújo, Bruna; Hugo JR Fernandes; Wade-Martins, Richard. "Repurposing Multimodal Strategies for Parkinson’s Disease: Creating the Path for Disease Delay and Repair?". Paper presented in Brilliant PhDs, brighter future: Shaping Science together! (PhDay 2023), 2023.
  4. Araújo, Bruna; Caridade-Silva, Rita; Svenningsson, Per; Luísa Pinto; Fábio G. Teixeira. "Modulation of Adult Hippocampal Neurogenesis by Antidepressants May Aid the Prevention of Parkinson's Disease". Paper presented in Brilliant PhDs, brighter future: Shaping Science together! (PhDay 2023), 2023.
  5. Araújo, Bruna; Campos, Jonas; Caridade-Silva, Rita; Mendes-Pinheiro, Bárbara; Marques, Cláudia Raquel; Barata-Antunes, Sandra; Lima, Rui; et al. "Modulation of Brain Connectivity, Structure, and Motor Function by Safinamide Multimodal Actions in a Pre-clinical Model of Parkinson¿s Disease". Paper presented in 11th IBRO - World Congress of Neuroscience 2023, 2023.
  6. Araújo, Bruna; Joana Catarina Martins Macedo; Silveira-Rosa, Tiago; Patrícia Carvalho Patrício; Loureiro-Campos, Eduardo (EF11-B5BA-1D82; Caridade-Silva, Rita; Teixeira, Fábio Gabriel; et al. "Hilus, a new cytogenic hippocampal niche modulated by stress exposure and treatment with antidepressants". Paper presented in 11th IBRO - World Congress of Neuroscience 2023, 2023.
  7. Caridade-Silva, Rita; Araújo, Bruna; Martins-Macedo, Joana; Larrat, Benoit; Meriaux, Sebastien; Teixeira, Fábio G. "Impact of N-acetylcysteine on Parkinson's Disease Functional Connectomics: A Friend or Foe?". Paper presented in 11th IBRO World Congress of Neuroscience 2023, 2023.
  8. Araújo, Bruna; Campos, Jonas; Caridade-Silva, Rita; Mendes-Pinheiro, Bárbara; Marques, Cláudia Raquel ; Barata-Antunes, Sandra; Rui Augusto Ribeiro Lima; et al. "Modulation of Brain Structure and Motor Function by Safinamide Multimodal Actions in a Pre-clinical Model of Parkinson's Disease". Paper presented in FENS Regional Meeting 2023, 2023.
  9. Araújo, Bruna; Campos, Jonas; Caridade-Silva, Rita; Domingues, Helena Sofia; Mendes-Pinheiro, Bárbara; Marques, Cláudia Raquel ; Barata-Antunes, Sandra; et al. "Addressing the Impact of Safinamide as a Parkinson's Disease Neuroprotective Drug". Paper presented in International conference on Alzheimer's and Parkinson's Disease and related neurological disorders (2022), 2022.
  10. Araújo, Bruna; Caridade-Silva, Rita; Magalhães, Ricardo; Larrat, Benoit; Meriaux, Sebastien; Pêgo, Ana Paula; Teixeira, Fábio Gabriel. "Targetting Parkinson's Disease Brain Affected Areas by the local delivery of multimodal pharmacological strategies". Paper presented in European Neuroscience Conference by Doctoral Students (ENCODS), 2021.
  11. Caridade-Silva, Rita; Araújo, Bruna; Campos, Jonas; Domingues, Helena S.; Salgado, António José; Teixeira, Fábio G. "Combining Stem Cells Secretome and N-acetylcysteine to Parkinson's Disease modeling and repair.". Paper presented in European Neuroscience Conference by Doctoral Students (ENCODS), 2021.
Journal article
  1. Vilela, Cristiana; Araújo, Bruna; Soares-Guedes, Carla; Caridade-Silva, Rita; Martins-Macedo, Joana; Teixeira, Catarina; Gomes, Eduardo D.; et al. "From the Gut to the Brain: Is Microbiota a New Paradigm in Parkinson’s Disease Treatment?". Cells 13 9 (2024): 770. http://dx.doi.org/10.3390/cells13090770.
    10.3390/cells13090770
  2. Caridade-Silva, Rita; Araújo, Bruna; Martins-Macedo, Joana; Teixeira, Fábio G.. "N-Acetylcysteine Treatment May Compensate Motor Impairments through Dopaminergic Transmission Modulation in a Striatal 6-Hydroxydopamine Parkinson's Disease Rat Model". Antioxidants 12 6 (2023): 1257. http://dx.doi.org/10.3390/antiox12061257.
    Published • 10.3390/antiox12061257
  3. Silva, Rita Caridade; Domingues, Helena Sofia; Salgado, António José; Teixeira, Fábio Gabriel. "From regenerative strategies to pharmacological approaches: can we fine-tune treatment for Parkinson's disease?". Neural Regeneration Research 17 5 (2021): 933-936. https://doi.org/10.4103/1673-5374.324827.
    Open access • Published • 10.4103/1673-5374.324827
Thesis / Dissertation
  1. "Combining Stem Cells Secretome and N-acetylcysteine to Parkinson's Disease modeling and repair". Master, Universidade do Minho Escola de Medicina, 2021.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10/04 Poster pitch "Repurposing Multimodal Strategies for Parkinson’s Disease: Creating the Path for Disease Delay and Repair" Brilliant PhDs, brighter future: Shaping Science together! (PhDay 2023)
Instituto de Investigação e Inovação em Saúde, 4200-135 , Porto, Porto, Portugal (Porto, Portugal)
2022/03/20 N-acetylcysteine as a Parkinson's disease therapy: creating a strategy for disease modeling and repair International conference on Alzheimer's and Parkinson's Disease and related neurological disorders
(Barcelona, Spain)

Event participation

Activity description
Type of event
Event name
Institution / Organization
2024/04/05 - 2024/04/05 VIII Symposium of the PT Glia Network
Symposium
VIII Symposium of the PT Glia Network
2024 - 2024 Scientific Poster Presentation AD/PD 2024
Conference
International conference on Alzheimer's and Parkinson's Disease and related neurological disorders , Lisbon
2023/10/03 - 2023/10/04 Scientific Poster Presentation PhDay 2023
Meeting
Brilliant PhDs, brighter future: Shaping Science together! (PhDay 2023)
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2023/09/09 - 2023/09/13 Scientific Poster Presentation 11th IBRO World Congress of Neuroscience 2023
Congress
11th IBRO World Congress of Neuroscience 2023
International Brain Research Organization, France

Sociedad Española de Neurociencia, Spain
2022/10/18 - 2022/10/18 VI Symposium of the Portuguese Glial Network
Symposium
VI Symposium of Portuguese Glial Network
2021/06/04 - 2021/06/06 Scientific Poster Presentation (ENCODS)
Conference
European Neuroscience Conference by Doctoral Students (ENCODS) 2021
2018/02 - 2018/02 XIX Applied Biology Meeting
Meeting
XIX Applied Biology Meeting
2017/02 - 2017/02 XVIII Applied Biology Meeting
Meeting
XVIII Applied Biology Meeting

Association member

Society Organization name Role
2024 - Current Portuguese Society for Neuroscience (SPN)

Committee member

Activity description
Role
Institution / Organization
2019/03/11 - 2019/03/15 I Science' Journeys
Member
Universidade do Minho Escola de Ciências, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024/02 - Current Biochemistry, Pharmacy degree, ESS/P.Porto Biochemistry (Licenciatura) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2024 - Current Biochemistry, Degree in Cultures and Laboratoty Maintenance Degree, ESS/P.Porto Biochemistry (Curso Técnico Superior Profissional) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2024 - Current Biochemistry, Degree in Health Products and Food Supplements, ESS/P.Porto Biochemistry (Curso Técnico Superior Profissional) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
2023/09 - 2024/02 Applied Biochemistry, Degree in Radioactive Material in a Biomedical Context, ESS/P.Porto Applied Biochemistry (Curso Técnico Superior Profissional) Instituto Politecnico do Porto Escola Superior de Tecnologia da Saúde do Porto, Portugal
Distinctions

Award

2024 Travel Grant to attend the FENS Forum of Neuroscience, Vienna, Austria
2023 PAPRE (Programme of Support for Publication in High Quality Scientific Journals)
Instituto Politécnico do Porto, Portugal
2021 Scientific Poster Presentation
European Neuroscience Conference by Doctoral Students (ENCODS), United Kingdom