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Daniela Monteiro Fernandes graduated in Biochemistry by the University of Minho in 2016 and received her MSc in Health Sciences from the same institution. Latter that year, she joined Dr. Patrícia Maciel's team as a research fellow, aiming to dissect the role of glial cells for Machado-Joseph disease onset and progression. After completing this fellowship, she enrolled in a PhD program funded by FCT, focusing on the behavioral, neuropathological, and neuronal circuit characterization of a mouse model of Rett Syndrome, while evaluating the potential disease modifying effects of a novel candidate therapeutic compound for this disease, in collaboration with the biopharmaceutical company Neurolixis. She is curently a research fellow in the same lab, working on a ERA-NET funded project. Her scientific outputs include 9 publications in international peer-reviewed journals, including in Molecular Psychiatry and Journal of Clinical Investigation, 3 oral communications as first author in international scientific meetings and co-authorship in several works.
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Identification

Personal identification

Full name
Daniela Monteiro Fernandes

Citation names

  • Monteiro-Fernandes, Daniela

Author identifiers

Ciência ID
F617-AC69-3D41
ORCID iD
0000-0002-0407-9970
Scopus Author Id
57216955101

Email addresses

  • id8942@alunos.uminho.pt (Professional)

Telephones

Telephone
  • 253604835 (Professional)

Addresses

  • Campus de Gualtar, 4710-057, Braga, Braga, Portugal (Professional)

Websites

Knowledge fields

  • Medical and Health Sciences
  • Medical and Health Sciences - Medical Biotechnology - Technologies Involving the Manipulation of Cells, Tissues, Organs or the Whole Organism
  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese (Mother tongue)
Education
Degree Classification
2020 - 2024
Ongoing
 Ciências da Saúde (Doutoramento)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022
Concluded
 Bioinformatics in Health Sciences (Curso de doutoramento (conclusão de unidades curriculares))
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2022
Concluded
 Advanced methods for imaging and manipulation of neuronal circuits in vivo (Curso de doutoramento (conclusão de unidades curriculares))
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/09 - 2018/06
Concluded
 Ciências da Saúde (Mestrado)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
"A positive modulator of AMPA receptors against AD pathology: in vivo studies" (THESIS/DISSERTATION)
 16
2018/01/30 - 2018/02/10
Concluded
 Laboratory Animal Science (LAS) (Outros)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2013/09 - 2016/06
Concluded
 Bioquímica (Licenciatura)
Universidade do Minho, Portugal
"Role of conditional Tau deletion in brain structure and function" (THESIS/DISSERTATION)
 15
Affiliation

Science

Category
Host institution 		Employer
2024/04/12 - 2025/03/31 Researcher (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018 - 2020 Research Assistant (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2018 - 2018 Research Trainee (Research) Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Universität Osnabrück, Germany

Others

Category
Host institution 		Employer
2020 - Current PhD student Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
Projects

Grant

Designation Funders
2020 - Current Defining novel behavioral traits and new therapeutic opportunities in a clinically relevant mouse model of Rett Syndrome
SFRH/BD/147947/2019
PhD Student Fellow
Fundação para a Ciência e a Tecnologia
2024 - 2025/03/31 Development of over-inhibition of cortical circuits in Down Syndrome
NEURON/0001/2021
Research Fellow
2018/12/27 - 2020/03/27 Role of glial cells in the neurodegenerative process in Machado-Joseph disease
PTDC/NEU-NMC/3648/2014
Research Fellow
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Associação para a Inovação e Desenvolvimento da FCT
Ongoing

Other

Designation Funders
2017 - 2019/03/31 A novel modulator of AMPA receptors against Alzheimer's Disease pathology: the first in vivo evidence
Servier_ICVS_2017_003
Other
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
 Laboratoires Servier Industrie
Ongoing
2017 - 2018 Tau as converging protein in the chronic stress and Alzheimer's disease synaptic pathologies
missing
Other
Universität Osnabrück, Germany
Ongoing
Outputs

Publications

Conference abstract
  1. Correia, J; Monteiro-Fernandes, D; Guerreiro, S; Ferreira-Lomba, B; Cunha-Garcia, D; Gomes, P; Teixeira-Castro, A; Duarte-Silva, S; Maciel, P. "Understanding the regulation of stress responses in a mouse model of SCA3". Paper presented in International Congress for Ataxia Research (ICAR), 2024.
  2. Ferreira-Lomba, B; Duarte-Silva, S; Guerreiro, S; Cunha-Garcia, D; Oliveira, S; Vieira, C; Pereira-Sousa, J; et al. "Therapeutic efficacy of chronic 5-HT1A receptor agonism by NLX-112 (befiradol) in Spinocerebellar Ataxia Type 3 mice". Paper presented in International Congress for Ataxia Research (ICAR), 2024.
  3. Monteiro-Fernandes, D; Charles, I; Guerreiro, S; Cunha-Garcia, D; Varney, M.A; Kleven, M.S; Newman-Tancredi, A; et al. "Selective biased agonism of 5-HT1AR rescues respiratory and cognitive impairments but not the movement disorder component in Rett Syndrome mice". Paper presented in SDPMov, 2024.
  4. Guerreiro, S; Monteiro-Fernandes, D; Duarte-Silva, S; Maciel, P. "Characterization of the movement disorder phenotype of a mouse model of Down Syndrome". Paper presented in Midterm symposium JTC 2021 on Neurodevelopmental Disorders, 2024.
  5. Guerreiro, S; Monteiro-Fernandes, D; Duarte-Silva, S; Maciel, P. "Characterization of the movement disorder phenotype of a mouse model of Down Syndrome". Paper presented in 5th T21RS International Conference, 2024.
Conference poster
  1. Correia, Joana Sofia; Monteiro-Fernandes, Daniela; Guerreiro, Sara; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela; Gomes, Patrícia; Duarte-Silva, Sara; Maciel, Patrícia. "Assessing the HPA-axis mediated stress responses in a mouse model of SCA3". Paper presented in 11th IBRO World Congress of Neuroscience, 2023.
  2. Vieira, C; Guerreiro, S; Duarte-Silva, S; Monteiro-Fernandes, D; Ferreira-Lomba, B; Maciel, P; Teixeira-Castro, A. "Limited Therapeutic Impact of Intermittent Fasting and Ketogenic diets in a Mouse Model of Spinocerebellar Ataxia Type 3". Paper presented in International Society of Neurochemistry (ISN) and the European Society of Neurochemistry (ESN), 2023.
  3. Monteiro-Fernandes, D; Guerreiro, S; Gomes, P; Domingues, AV; Soares-Cunha, C; Coimbra, B; Santos, A; et al. "Defining novel behavioural and neurophysiological features and testing a 5HT1A-targeting therapeutic agent in a clinically relevant mouse model of Rett Syndrome". Paper presented in ISN, 2022.
  4. Correia, Joana Sofia; Monteiro-Fernandes, Daniela; Guerreiro, Sara; Ferreira-Lomba, Bruna; Cunha-Garcia, Daniela; Gomes, Patricia; Duarte-Silva, Sara; Maciel, Patricia. "The study of depression and cognitive comorbidities in a mouse model of spinocerebellar ataxia type 3". Paper presented in ISN, 2022.
  5. Monteiro-Fernandes, D.; Guerreiro, S; Gomes, P; Domingues, AV; Soares-Cunha, C; Coimbra, B; Santos, A; et al. "Integration of behavior and neuronal physiology in a mouse model of Rett Syndrome: a focus on serotonergic system modulation". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN), Coimbra – Portugal., 2021.
  6. Vidinha-Mira, A; Monteiro-Fernandes, D; Guerreiro, S; Cunha-Garcia, D; Ferreira-Lomba, B; Oliveira, S; Silva, J; et al. "Can chronic activation of serotonergic signalling be atherapeutic approach for neurodegenerative diseases?". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN), Coimbra – Portugal., 2021.
  7. Correia, J.S; Monteiro-Fernandes, D; Guerreiro, S; Lomba, B; Cunha-Garcia, D; Gomes, P; Viana, J; Duarte-Silva, S; Maciel, P. "Do MJD mice present a cerebellar cognitive affective syndrome?". Paper presented in XVII Meeting of the Portuguese Society for Neurosciences (SPN), Coimbra – Portugal, 2021.
  8. Vidinha-Mira, A; Monteiro-Fernandes, Daniela; Guerreiro, S; Vieira, C; Cunha-Garcia, D; Ferreira-Lomba, B; Oliveira, S; et al. "Does activation of serotonergic treatment suppressproteotoxicity in mouse models of neurodegenerative diseases?". Paper presented in 16th Young European Scientist (YES) Meeting, Porto - Portugal, 2021.
  9. Vidinha-Mira, A; Monteiro-Fernandes, D; Guerreiro, S; Almeida, B; Duarte-Silva, S; Teixeira-Castro, A. "Serotonergic Signalling Activation as a Therapeutic Approach for Neurodegenerative Diseases". Paper presented in IJUP'21 - 14th Young Investigation Meeting of University of Porto, 2021.
  10. Monteiro, Daniela; Silva, JM; Soares-Cunha, C; Ferreira, S; Bretin, S; Sousa, N ; Sotiropoulos, I. "A novel modulator of AMPA receptors against AD pathology: the first in vivo evidence". Paper presented in EuroTau Meeting, 2018.
    10.1109/gemic.2009.4815868
  11. Monteiro, Daniela; Silva, JM; Soares-Cunha, C; Ferreira, S; Bretin, S; Sousa, N ; Sotiropoulos, I. "A novel modulator of AMPA receptors against AD pathology: the first in vivo evidence". Paper presented in ECNP Workshop for Junior Scientists, 2018.
  12. Monteiro, Daniela; Silva, JM; Soares-Cunha, C; Bretin, S; Sousa, N ; Sotiropoulos, I. "A novel allosteric modulator of AMPA receptor against Alzheimer’s disease pathology". Paper presented in Alzheimer's & Parkinson's Diseases Congress, 2018.
  13. Monteiro, Daniela; Silva, JM; Ferreira, S; Soares-Cunha, C; Bretin, S; Sousa, N ; Sotiropoulos, I. "A novel modulator of AMPA receptors against AD pathology: the first in vivo evidence". Paper presented in Bulgaria AAIC Satellite Symposium, 2017.
  14. Monteiro, Daniela; Almeida, OFX; Sousa, N ; Sotiropoulos, I. "Identifying the molecular underpinning of altered corticosteroid milieu in brain". Paper presented in Portuguese Society of Neurosciences, 2017.
Journal article
  1. Macedo-Ribeiro, Sandra. "Allosteric Modulation of Pathological Ataxin-3 Aggregation: A Path to Spinocerebellar Ataxia Type-3 Therapies". BioRxiv (2025):
  2. Sara Duarte-Silva; Jorge Diogo Da Silva; Daniela Monteiro-Fernandes; Marta Daniela Costa; Andreia Neves-Carvalho; Mafalda Raposo; Carina Soares-Cunha; et al. "Glucocorticoid receptor-dependent therapeutic efficacy of tauroursodeoxycholic acid in preclinical models of Spinocerebellar ataxia type 3". Journal of Clinical Investigation (2024):
    Published • 10.1172/JCI162246
  3. Cunha-Garcia, Daniela; Monteiro-Fernandes, Daniela; Correia, Joana Sofia; Neves-Carvalho, Andreia; Vilaça-Ferreira, Ana Catarina; Guerra-Gomes, Sónia; Viana, João Filipe; et al. "Genetic Ablation of Inositol 1,4,5-Trisphosphate Receptor Type 2 (IP3R2) Fails to Modify Disease Progression in a Mouse Model of Spinocerebellar Ataxia Type 3". International Journal of Molecular Sciences 24 13 (2023): 10606. http://dx.doi.org/10.3390/ijms241310606.
    10.3390/ijms241310606
  4. Mayoral-Palarz, Kristin; Neves-Carvalho, Andreia; Duarte-Silva, Sara; Monteiro-Fernandes, Daniela; Maciel, Patrícia; Khodakhah, Kamran. "Cerebellar neuronal dysfunction accompanies early motor symptoms in spinocerebellar ataxia type 3". Disease Models & Mechanisms 15 8 (2022): http://dx.doi.org/10.1242/dmm.049514.
    10.1242/dmm.049514
  5. Campos, Ana Bela; Duarte-Silva, Sara; Fernandes, Bruno; Coimbra, Bárbara; Campos, Jonas; Monteiro-Fernandes, Daniela; Teixeira-Castro, Andreia; Ambrósio, António Francisco; Maciel, Patrícia. "Microglial Depletion Has No Impact on Disease Progression in a Mouse Model of Machado–Joseph Disease". Cells 11 13 (2022): 2022. http://dx.doi.org/10.3390/cells11132022.
    10.3390/cells11132022
  6. Campos, Ana Bela; Duarte-Silva, Sara; Fernandes, Bruno; das Neves, Sofia Pereira; Marques, Fernanda; Teixeira-Castro, Andreia; Neves-Carvalho, Andreia; et al. "Profiling Microglia in a Mouse Model of Machado–Joseph Disease". Biomedicines 10 2 (2022): 237. http://dx.doi.org/10.3390/biomedicines10020237.
    10.3390/biomedicines10020237
  7. Mendes-Pinheiro, Bárbara; Soares-Cunha, Carina; Marote, Ana; Loureiro-Campos, Eduardo; Campos, Jonas; Barata-Antunes, Sandra; Monteiro-Fernandes, Daniela; et al. "Unilateral Intrastriatal 6-Hydroxydopamine Lesion in Mice: A Closer Look into Non-Motor Phenotype and Glial Response". International Journal of Molecular Sciences 22 21 (2021): 11530. http://dx.doi.org/10.3390/ijms222111530.
    10.3390/ijms222111530
  8. Monteiro-Fernandes, D.; Sousa, N.; Almeida, O.F.X.; Sotiropoulos, I.. "Sex Hormone Depletion Augments Glucocorticoid Induction of Tau Hyperphosphorylation in Male Rat Brain". Neuroscience (2021): http://dx.doi.org/10.1016/j.neuroscience.2020.05.049.
    10.1016/j.neuroscience.2020.05.049
  9. Monteiro-Fernandes, Daniela; Silva, Joana Margarida; Soares-Cunha, Carina; Dalla, Christina; Kokras, Nikolaos; Arnaud, François; Billiras, Rodolphe; et al. "Allosteric modulation of AMPA receptors counteracts Tau-related excitotoxic synaptic signaling and memory deficits in stress- and Aß-evoked hippocampal pathology". Molecular Psychiatry (2020): https://doi.org/10.1038/s41380-020-0794-5.
    10.1038/s41380-020-0794-5
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2024/01 Enhancing Animal Welfare and Research Accuracy with DVC®: A study on Non-Intrusive Monitoring of Rodent Behaviour and Activity SPCAL
2023/08 Defining novel behavioural and neurophysiological features in a clinically relevant mouse model of Rett Syndrome: 5HT1AR therapeutic potential ISN
2019/03/29 A novel role for Tau protein in the mechanisms of brain damage caused by peripheral neuropathy 14th International Conference of Alzheimer's and Parkinson diseases (AD/PD) 2019
(Lisbon, Portugal)
2018/05 A novel modulator of AMPA receptors against Alzheimer’s disease pathology: the first in vivo evidence Conference of Basic and Clinical Pharmacology Hellenic Society
Hellenic Society (Greece)

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2024/01 - Current Scientific advances in Rett Syndrome therapies (2024/01)
Seminar
 Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Event participation

Activity description
Type of event 		Event name
Institution / Organization
2023 - Current Brain Awareness Week: "Os Mistérios do Cérebro"
2023 - Current Rare Disease Day Activities: "Light up for rare - Global Chain of Lights"
2023 - Current European Researchers’ Night 2023: "Discovering the Connections between Space and Human Health”
2019/07 - 2019/07 Attendee ICVS Satellite Meeting “Decoding astrocyte-neuron dialogues that produce brain outputs”
2019/05 - 2019/05 Attendee
Symposium
 IV Symposium Portuguese Glia Network “Glia diversity in neuromodulation and Neurodegeneration”
2019 - 2019 Poster presentation
Congress
 Alzheimer's & Parkinson's DiseasesCongress
2018 - 2018 Poster presentation
Workshop
 ECNP Workshop forJunior Scientists
2018 - 2018 Poster presentation
Congress
 EuroTau Meeting
2017 - 2018 Poster presentation
Congress
 Portuguese Society of Neurosciences
2017/04/26 - 2017/05/12 Course attendee Hands-on the rodent brain: from intracellular trafficking to brain connectome (1th Edition)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/01/30 - 2017/03/10 Course attendee Laboratory Animal Science (12th Edition)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017/01/09 - 2017/01/27 Course attendee Biostatistics in Health Science (8th Edition)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2017 - 2017 Poster presentation
Congress
 Bulgaria AAICSatellite Symposium
2016/10/24 - 2016/11/11 Course attendee Fundamentals in Genetics, Development and Neoplasia (8th Edition)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2016/10/03 - 2016/10/21 Course attendee Fundamentals in Immunology and Infection (8th Edition)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal
2012/09/12 - 2012/09/23 Course attendee Fundamentals in Neuroscience (9th Edition)
Universidade do Minho Instituto de Investigação em Ciências da Vida e Saúde, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2024 - Current Fundamentals in Neurosciences
Distinctions

Award

2023 Travel Fellowship for the International Society of Neurochemistry (ISN)
2022 Travel Fellowship for the International Society of Neurochemistry (ISN)
2018 Travel Grant
European College of Neuropsychopharmacology, Netherlands
2017 Travel Fellowship at the European College of Neuropsychopharmacology (ECNP) workshop for Junior Scientists,
Alzheimer's Association, United States