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Ira Milosevic. Concluiu o(a) Doctor of Philosophy em PhD in Neuroscience em 2006 pelo(a) Georg-August-Universität Göttingen, Master em MSc in Neuroscience em 2003 pelo(a) Georg-August-Universität Göttingen e Licence em Diploma (Dipl. Ing.) in Molecular Biology em 2001 pelo(a) Sveucili¿te u Zagrebu Prirodoslovno-Matematicki Fakultet. É Investigador Coordenador (carreira) no(a) Universidade de Coimbra e Investigador principal (carreira) no(a) University of Oxford. Publicou 42 artigos em revistas especializadas. Possui 4 capítulo(s) de livros. Organizou 13 evento(s). Orientou 5 tese(s) de doutoramento e coorientou 3. Orientou 14 dissertação(ões) de mestrado e coorientou 2. Recebeu 9 prémio(s) e/ou homenagens. Participa e/ou participou como Investigador em 1 projeto(s) e Investigador responsável em 9 projeto(s). Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Neurociências.
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Identification

Personal identification

Full name
Ira Milosevic

Citation names

  • Milosevic, Ira

Author identifiers

Ciência ID
F61C-2A69-493D
ORCID iD
0000-0001-6440-3763

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Croatian (Mother tongue)
German Advanced (C1) Proficiency (C2) Advanced (C1) Advanced (C1) Advanced (C1)
Portuguese Beginner (A1) Beginner (A1) Beginner (A1) Elementary (A2) Beginner (A1)
Education
Degree Classification
2003 - 2006
Concluded
 PhD in Neuroscience (Doctor of Philosophy)
Georg-August-Universität Göttingen, Germany
 Summa cum laude
2001 - 2003
Concluded
 MSc in Neuroscience (Master)
Georg-August-Universität Göttingen, Germany
1996 - 2001
Concluded
 Diploma (Dipl. Ing.) in Molecular Biology (Licence)
Sveucilište u Zagrebu Prirodoslovno-Matematicki Fakultet, Croatia
 5.0/5.0 from 51 exams
Affiliation

Science

Category
Host institution 		Employer
2021/03/01 - Current Coordinating Researcher (Research) Universidade de Coimbra, Portugal
Multidisciplinary Institute for Ageing (MIA-Portugal), Portugal
2020/10 - Current Principal Investigator (Research) University of Oxford, United Kingdom
University of Oxford Nuffield Department of Clinical Medicine, United Kingdom
2013 - 2021 Principal Investigator (Research) Europäisches Neurowissenschaftliches Institut Göttingen, Germany
Projects

Grant

Designation Funders
2020/10 - Current John Black Senior Research Fellowship in Parkinson's Disease
John Black Senior Research Fellowship
Principal investigator
Ongoing
2022/10/01 - 2029/09/30 Novel mechanisms of v-ATPase regulation in vertebrates
Wellcome Trust Investigator
Principal investigator
University of Oxford, United Kingdom
 Wellcome Trust
Ongoing
2022/12/01 - 2025/12/01 Endosomal sub-compartments in health and disease
La Caixa
Principal investigator
Multidisciplinary Institute for Ageing (MIA-Portugal), Portugal
 Centro de la Fundació Caixa Castelló
Ongoing
2021/03/29 - 2024/03/28 A maturacao da vesicula sinaptica e a sua relevancia para a neurodegeneracao
PTDC/MED-NEU/8030/2020
Principal investigator
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
2021/05/01 - 2023/04/30 Mechanisms of neurodegeneration caused by defective endocytosis
0010447
Principal investigator
University of Oxford John Fell Fund, United Kingdom
Ongoing
2016/01 - 2021/01 Characterization of mitochondria-ER contact sites and their role in cellular signalling (P02)
grant.290025802
Principal investigator
Deutsche Forschungsgemeinschaft
Ongoing
2016/01 - 2021/01 Dynamic Membrane Traffic at the Neuronal Synapse
T287/25457
Principal investigator
Schram Stiftung
Ongoing
2015/01 - 2020/01 Molecular physiology of synaptic vesicle recycling at the hair cell ribbon synapse (A08*)
grant.269009167
Principal investigator
Deutsche Forschungsgemeinschaft
2013/01 - 2020/01 Pathological mechanisms of synaptic vesicle recycling
grant.224837277
Principal investigator
Deutsche Forschungsgemeinschaft
2016/09 - 2019/09 The role of phosphoinositides in platelet formation
grant.2400
Researcher
Hrvatska Zaklada za Znanost
Outputs

Publications

Book chapter
  1. Milosevic, Ira; Jefferson D Knight. "Exocytotic SNARE complex assembly, disassembly, and regulation". In Exocytosis from Molecules to Cells (Biophysical Society). United States: https://iopscience.iop.org/book/edit/978-0-7503-3771-7, 2022.
    Published
  2. Milosevic, Ira. "Spatial and Temporal Aspects of Exocytosis Studied on the Isolated Plasma Membranes". In Methods in Molecular Biology, 311-325. Springer US, 2020.
    10.1007/978-1-0716-1044-2_21
  3. Milosevic, Ira. "Spatial and Temporal Aspects of Phosphoinositides in Endocytosis Studied in the Isolated Plasma Membranes". In Clathrin-Mediated Endocytosis, 147-160. Springer New York, 2018.
    Published • 10.1007/978-1-4939-8719-1_11
  4. Milosevic, Ira. "Fusion machinery: SNARE protein complex.". In Presynaptic Terminals, 87-127. Springer Japan, 2015.
    Published
Conference poster
  1. DIAS, ROBERTO; Gaspar-Silva, Filipa; Milosevic, Ira; Raimundo, Nuno. "Role of Lysosome-Mitochondria Membrane Contact Sites in Nutrient Sensing". Paper presented in 3 rd RESETageing Conference, 2023.
  2. Aveleira, Célia; Gaspar, Rita; Thibaud Martial; Raimundo, Nuno; Milosevic, Ira. "Loss of dynamin triggers cell senescence, nuclear envelope abnormalities and accumulation of DNA damage". Paper presented in 3rd RESETageing Conference, 2023.
  3. Caulino-Rocha, Ana; Bura, Ana; Rostosky, Christine; Carmo-Silva, Sara; Raimundo, Nuno; Milosevic, Ira. "Modulation of E3-ubiquitin Ligase Fbxo32 Rescues Dopaminergic Axon Dysmorphology and the Ubiquitin system in Endophilin-A Mutants.". Paper presented in RESET meeting, 2023.
  4. Caulino-Rocha, Ana; Bura, Ana; Rostosky, Christine; Carmo-Silva, Sara; Raimundo, Nuno; Milosevic, Ira. "Reduction of FBXO32 rescues dopaminergic axonal pathology in Endophilin-A mutants". Paper presented in Champalimaud Research Symposium 23, 2023.
  5. Caulino-Rocha, Ana; Bura, Ana; Rostosky, Christine; Carmo-Silva, Sara; Raimundo, Nuno; Milosevic, Ira. "Endophilin-A mutants display age-dependent alterations in the dopaminergic system". Paper presented in FENS Regional Meeting 2023, 2023.
  6. Carvalhais, Lia G; Milosevic, Ira; Ana Luísa Carvalho; Pinheiro, PS. "New insights into the roles of SNAP-29 in neuronal and synaptic functions". Paper presented in 8th European Synapse Meeting, 2022.
  7. Couto, Renata; del Rio, Zurine; Yambire, KF; Bogeski, I; Milosevic, Ira; Raimundo, Nuno. "Identification of signaling mechanisms regulating mitochondria-endoplasmic reticulum contact sites". Paper presented in 13th Göttingen Meeting of the German Neuroscience Society, 2019.
  8. Couto, Renata; Milosevic, Ira; Raimundo, Nuno. "Identification of signaling mechanisms regulating the number of ER-mitochondria contact sites.". Paper presented in EMBO Workshop MCS, Arosa, Switzerland, 2018.
Journal article
  1. Musa, Marina; Dionisio, Pedro A; Casqueiro, Ricardo; Milosevic, Ira; Raimundo, Nuno; Krisko, Anita. "Lack of peroxisomal catalase affects heat shock response inCaenorhabditis elegans". Life Science Alliance 6 1 (2022): e202201737. http://dx.doi.org/10.26508/lsa.202201737.
    Published • 10.26508/lsa.202201737
  2. Upmanyu, Neha; Jin, Jialin; Emde, Henrik von der; Ganzella, Marcelo; Bösche, Leon; Malviya, Viveka Nand; Zhuleku, Evi; et al. "Colocalization of different neurotransmitter transporters on synaptic vesicles is sparse except for VGLUT1 and ZnT3". Neuron 110 9 (2022): 1483-1497.e7. http://dx.doi.org/10.1016/j.neuron.2022.02.008.
    Published • 10.1016/j.neuron.2022.02.008
  3. Milosevic, Ira; Cousin, Michael A.. "Fine-tuning activity-dependent bulk endocytosis via kinases and phosphatases". Journal of Cell Biology 220 12 (2021): http://dx.doi.org/10.1083/jcb.202111056.
    Published • 10.1083/jcb.202111056
  4. Mould, Arne W.; Hall, Nicola A.; Milosevic, Ira; Tunbridge, Elizabeth M.. "Targeting synaptic plasticity in schizophrenia: insights from genomic studies". Trends in Molecular Medicine 27 11 (2021): 1022-1032. http://dx.doi.org/10.1016/j.molmed.2021.07.014.
    Published • 10.1016/j.molmed.2021.07.014
  5. Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; et al. "Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1". Autophagy 17 1 (2021): 1-382. http://dx.doi.org/10.1080/15548627.2020.1797280.
    Published • 10.1080/15548627.2020.1797280
  6. Milosevic, Ira. Corresponding author: Milosevic, Ira. "Spatial and Temporal Aspects of Exocytosis Studied on the Isolated Plasma Membranes". Methods Mol Biol 2233 (2021): 311-313. PMID: 33222144 DOI: 10.1007/978-1-0716-1044-2_21.
    Published
  7. Sathyanarayanan, Udhayabhaskar; Musa, Marina; Bou Dib, Peter; Raimundo, Nuno; Milosevic, Ira; Krisko, Anita. "ATP hydrolysis by yeast Hsp104 determines protein aggregate dissolution and size in vivo". Nature Communications 11 1 (2020): http://dx.doi.org/10.1038/s41467-020-19104-1.
    10.1038/s41467-020-19104-1
  8. Kroppen, Benjamin; Teske, Nelli; Yambire, King F.; Denkert, Niels; Mukherjee, Indrani; Tarasenko, Daryna; Jaipuria, Garima; et al. "Cooperativity of membrane-protein and protein–protein interactions control membrane remodeling by epsin 1 and affects clathrin-mediated endocytosis". Cellular and Molecular Life Sciences (2020): http://dx.doi.org/10.1007/s00018-020-03647-z.
    10.1007/s00018-020-03647-z
  9. Milosevic, Ira. "PI(4,5)P2-dependent regulation of exocytosis by amisyn, a vertebrate-specific competitor of synaptobrevin 2". PNAS USA (2020):
    Open access • Accepted
  10. Milosevic, Ira. "Endophilin-A controls recruitment, priming and fusion of neurosecretory vesicles via intersectin". Nat Comm (2020): https://pubmed.ncbi.nlm.nih.gov/32152276/?from_term=Milosevic+I&from_sort=date&from_pos=1.
    Open access • In press
  11. Bertovic, Ivana; Kurelic, Roberta; Miloševic, Ira; Bender, Markus; Krauss, Michael; Haucke, Volker; Jurak Begonja, Antonija. "Vps34 derived phosphatidylinositol 3-monophosphate modulates megakaryocyte maturation and proplatelet production through late endosomes/lysosomes". Journal of Thrombosis and Haemostasis (2020): https://pubmed.ncbi.nlm.nih.gov/32056354/?from_term=Milosevic+I&from_sort=date&from_pos=5.
    In press • 10.1111/jth.14764
  12. Gowrisankaran, Sindhuja; Milosevic, Ira. "Regulation of synaptic vesicle acidification at the neuronal synapse". IUBMB Life (2020): http://dx.doi.org/10.1002/iub.2235.
    Open access • Published • 10.1002/iub.2235
  13. Kroll, Jana; Özçete, Özge Demet; Jung, Sangyong; Maritzen, Tanja; Milosevic, Ira; Wichmann, Carolin; Moser, Tobias. "AP180 promotes release site clearance and clathrin-dependent vesicle reformation in mouse cochlear inner hair cells". Journal of Cell Science 133 2 (2019): jcs236737. http://dx.doi.org/10.1242/jcs.236737.
    Open access • Published • 10.1242/jcs.236737
  14. Yambire, King Faisal; Rostosky, Christine; Watanabe, Takashi; Pacheu-Grau, David; Torres-Odio, Sylvia; Sanchez-Guerrero, Angela; Senderovich, Ola; et al. "Impaired lysosomal acidification triggers iron deficiency and inflammation in vivo". eLife 8 (2019): https://pubmed.ncbi.nlm.nih.gov/30917721/?from_term=Milosevic+I+G%C3%B6ttingen&from_sort=date&from_pos=8.
    Open access • Published • 10.7554/elife.51031
  15. Gowrisankaran, Sindhuja; Wang, Zuoneng; Morgan, David G.; Milosevic, Ira; Mim, Carsten. "Cells Control BIN1-Mediated Membrane Tubulation by Altering the Membrane Charge". Journal of Molecular Biology (2019): http://dx.doi.org/10.1016/j.jmb.2019.12.001.
    Open access • Published • 10.1016/j.jmb.2019.12.001
  16. Chanaday, Natali L.; Cousin, Michael A.; Milosevic, Ira; Watanabe, Shigeki; Morgan, Jennifer R.. "The Synaptic Vesicle Cycle Revisited: New Insights into the Modes and Mechanisms". The Journal of Neuroscience 39 42 (2019): 8209-8216. http://dx.doi.org/10.1523/jneurosci.1158-19.2019.
    Open access • Published • 10.1523/jneurosci.1158-19.2019
  17. Fonseca, Tiago Branco; Sánchez-Guerrero, Ángela; Milosevic, Ira; Raimundo, Nuno. "Mitochondrial fission requires DRP1 but not dynamins". Nature 570 7761 (2019): E34-E42. http://dx.doi.org/10.1038/s41586-019-1296-y.
    Published • 10.1038/s41586-019-1296-y
  18. Fernandez-Mosquera, Lorena; Yambire, King Faisal; Couto, Renata; Pereyra, Leonardo; Pabis, Kamil; Ponsford, Amy H.; Diogo, Cátia V.; et al. "Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis". Autophagy 15 9 (2019): 1572-1591. http://dx.doi.org/10.1080/15548627.2019.1586256.
    Open access • Published • 10.1080/15548627.2019.1586256
  19. Yambire, King Faisal; Fernandez-Mosquera, Lorena; Steinfeld, Robert; Mühle, Christiane; Ikonen, Elina; Milosevic, Ira; Raimundo, Nuno. "Mitochondrial biogenesis is transcriptionally repressed in lysosomal lipid storage diseases". eLife 8 (2019): http://dx.doi.org/10.7554/elife.39598.
    Open access • Published • 10.7554/elife.39598
  20. Kroll, Jana; Jaime Tobón, Lina M; Vogl, Christian; Neef, Jakob; Kondratiuk, Ilona; König, Melanie; Strenzke, Nicola; et al. "Endophilin-A regulates presynaptic Ca 2+ influx and synaptic vesicle recycling in auditory hair cells". The EMBO Journal 38 5 (2019): http://dx.doi.org/10.15252/embj.2018100116.
    Open access • Published • 10.15252/embj.2018100116
  21. Musa, Marina; Peric, Matea; Bou Dib, Peter; Sobocanec, Sandra; Šaric, Ana; Lovric, Anita; Rudan, Marina; et al. "Heat-induced longevity in budding yeast requires respiratory metabolism and glutathione recycling". Aging 10 9 (2018): 2407-2427. http://dx.doi.org/10.18632/aging.101560.
    Open access • Published • 10.18632/aging.101560
  22. Masaracchia, Caterina; Hnida, Marilena; Gerhardt, Ellen; Lopes da Fonseca, Tomás; Villar-Pique, Anna; Branco, Tiago; Stahlberg, Markus A.; et al. "Membrane binding, internalization, and sorting of alpha-synuclein in the cell". Acta Neuropathologica Communications 6 1 (2018): http://dx.doi.org/10.1186/s40478-018-0578-1.
    Open access • Published • 10.1186/s40478-018-0578-1
  23. Watanabe, Shigeki; Mamer, Lauren Elizabeth; Raychaudhuri, Sumana; Luvsanjav, Delgermaa; Eisen, Julia; Trimbuch, Thorsten; Söhl-Kielczynski, Berit; et al. "Synaptojanin and Endophilin Mediate Neck Formation during Ultrafast Endocytosis". Neuron 98 6 (2018): 1184-1197.e6. http://dx.doi.org/10.1016/j.neuron.2018.06.005.
    Open access • Published • 10.1016/j.neuron.2018.06.005
  24. Farsi, Zohreh; Gowrisankaran, Sindhuja; Krunic, Matija; Rammner, Burkhard; Woehler, Andrew; Lafer, Eileen M; Mim, Carsten; Jahn, Reinhard; Milosevic, Ira. "Clathrin coat controls synaptic vesicle acidification by blocking vacuolar ATPase activity". eLife 7 (2018): http://dx.doi.org/10.7554/elife.32569.
    Open access • Published • 10.7554/elife.32569
  25. Milosevic, Ira. "Revisiting the Role of Clathrin-Mediated Endoytosis in Synaptic Vesicle Recycling". Frontiers in Cellular Neuroscience 12 (2018): http://dx.doi.org/10.3389/fncel.2018.00027.
    Open access • Published • 10.3389/fncel.2018.00027
  26. Llorens, Franc; Thüne, Katrin; Tahir, Waqas; Kanata, Eirini; Diaz-Lucena, Daniela; Xanthopoulos, Konstantinos; Kovatsi, Eleni; et al. "YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias". Molecular Neurodegeneration 12 1 (2017): http://dx.doi.org/10.1186/s13024-017-0226-4.
    Open access • Published • 10.1186/s13024-017-0226-4
  27. Fiuza, Maria; Rostosky, Christine M.; Parkinson, Gabrielle T.; Bygrave, Alexei M.; Halemani, Nagaraj; Baptista, Marcio; Milosevic, Ira; Hanley, Jonathan G.. "PICK1 regulates AMPA receptor endocytosis via direct interactions with AP2 a-appendage and dynamin". The Journal of Cell Biology 216 10 (2017): 3323-3338. http://dx.doi.org/10.1083/jcb.201701034.
    Open access • Published • 10.1083/jcb.201701034
  28. Peric, Matea; Lovric, Anita; Šaric, Ana; Musa, Marina; Bou Dib, Peter; Rudan, Marina; Nikolic, Andrea; et al. "TORC1-mediated sensing of chaperone activity alters glucose metabolism and extends lifespan". Aging Cell 16 5 (2017): 994-1005. http://dx.doi.org/10.1111/acel.12623.
    Open access • Published • 10.1111/acel.12623
  29. Fernández-Mosquera, Lorena; Diogo, Cátia V.; Yambire, King Faisal; Santos, Gabriela L.; Luna Sánchez, Marta; Bénit, Paule; Rustin, Pierre; et al. "Acute and chronic mitochondrial respiratory chain deficiency differentially regulate lysosomal biogenesis". Scientific Reports 7 1 (2017): http://dx.doi.org/10.1038/srep45076.
    Open access • Published • 10.1038/srep45076
  30. Villar-Piqué, Anna; Lopes da Fonseca, Tomás; Sant’Anna, Ricardo; Szegö, Éva Mónika; Fonseca-Ornelas, Luis; Pinho, Raquel; Carija, Anita; et al. "Environmental and genetic factors support the dissociation between a-synuclein aggregation and toxicity". Proceedings of the National Academy of Sciences 113 42 (2016): E6506-E6515. http://dx.doi.org/10.1073/pnas.1606791113.
    Published • 10.1073/pnas.1606791113
  31. Murdoch, John D.; Rostosky, Christine M.; Gowrisankaran, Sindhuja; Arora, Amandeep S.; Soukup, Sandra-Fausia; Vidal, Ramon; Capece, Vincenzo; et al. "Endophilin-A Deficiency Induces the Foxo3a-Fbxo32 Network in the Brain and Causes Dysregulation of Autophagy and the Ubiquitin-Proteasome System". Cell Reports 17 4 (2016): 1071-1086. http://dx.doi.org/10.1016/j.celrep.2016.09.058.
    Open access • Published • 10.1016/j.celrep.2016.09.058
  32. Pechstein, Arndt; Gerth, Fabian; Milosevic, Ira; Jäpel, Maria; Eichhorn-Grünig, Marielle; Vorontsova, Olga; Bacetic, Jelena; et al. "Vesicle uncoating regulated by SH 3- SH 3 domain-mediated complex formation between endophilin and intersectin at synapses". EMBO reports 16 2 (2014): 232-239. http://dx.doi.org/10.15252/embr.201439260.
    Open access • Published • 10.15252/embr.201439260
  33. Cao, Mian; Milosevic, Ira; Giovedi, Silvia; De Camilli, Pietro. "Upregulation of Parkin in Endophilin Mutant Mice". The Journal of Neuroscience 34 49 (2014): 16544-16549. http://dx.doi.org/10.1523/jneurosci.1710-14.2014.
    Open access • Published • 10.1523/jneurosci.1710-14.2014
  34. Shen, Hongying; Giordano, Francesca; Wu, Yumei; Chan, Jason; Zhu, Chen; Milosevic, Ira; Wu, Xudong; et al. "Coupling between endocytosis and sphingosine kinase 1 recruitment". Nature Cell Biology 16 7 (2014): 652-662. http://dx.doi.org/10.1038/ncb2987.
    Published • 10.1038/ncb2987
  35. Giordano, Francesca; Saheki, Yasunori; Idevall-Hagren, Olof; Colombo, Sara Francesca; Pirruccello, Michelle; Milosevic, Ira; Gracheva, Elena O.; et al. "PI(4,5)P2-Dependent and Ca2+-Regulated ER-PM Interactions Mediated by the Extended Synaptotagmins". Cell 153 7 (2013): 1494-1509. http://dx.doi.org/10.1016/j.cell.2013.05.026.
    Open access • Published • 10.1016/j.cell.2013.05.026
  36. Soda, Keita; Balkin, Daniel M.; Ferguson, Shawn M.; Paradise, Summer; Milosevic, Ira; Giovedi, Silvia; Volpicelli-Daley, Laura; et al. "Role of dynamin, synaptojanin, and endophilin in podocyte foot processes". Journal of Clinical Investigation 122 12 (2012): 4401-4411. http://dx.doi.org/10.1172/jci65289.
    Open access • Published • 10.1172/jci65289
  37. Milosevic, Ira; Giovedi, Silvia; Lou, Xuelin; Raimondi, Andrea; Collesi, Chiara; Shen, Hongying; Paradise, Summer; et al. "Recruitment of Endophilin to Clathrin-Coated Pit Necks Is Required for Efficient Vesicle Uncoating after Fission". Neuron 72 4 (2011): 587-601. http://dx.doi.org/10.1016/j.neuron.2011.08.029.
    Open access • Published • 10.1016/j.neuron.2011.08.029
  38. Nagy, Gábor; Milosevic, Ira; Mohrmann, Ralf; Wiederhold, Katrin; Walter, Alexander M.; Sørensen, Jakob B.. "The SNAP-25 Linker as an Adaptation Toward Fast Exocytosis". Molecular Biology of the Cell 19 9 (2008): 3769-3781. http://dx.doi.org/10.1091/mbc.e07-12-1218.
    Open access • Published • 10.1091/mbc.e07-12-1218
  39. Gulyas-Kovacs, A.; de Wit, H.; Milosevic, I.; Kochubey, O.; Toonen, R.; Klingauf, J.; Verhage, M.; Sorensen, J. B.. "Munc18-1: Sequential Interactions with the Fusion Machinery Stimulate Vesicle Docking and Priming". Journal of Neuroscience 27 32 (2007): 8676-8686. http://dx.doi.org/10.1523/jneurosci.0658-07.2007.
    Open access • Published • 10.1523/jneurosci.0658-07.2007
  40. Sørensen, Jakob B; Wiederhold, Katrin; Müller, Emil M; Milosevic, Ira; Nagy, Gábor; de Groot, Bert L; Grubmüller, Helmut; Fasshauer, Dirk. "Sequential N- to C-terminal SNARE complex assembly drives priming and fusion of secretory vesicles". The EMBO Journal 25 5 (2006): 955-966. http://dx.doi.org/10.1038/sj.emboj.7601003.
    Open access • Published • 10.1038/sj.emboj.7601003
  41. Nagy, Gábor; Milosevic, Ira; Fasshauer, Dirk; Müller, E. Matthias; de Groot, Bert L.; Lang, Thorsten; Wilson, Michael C.; Sørensen, Jakob B.. "Alternative Splicing of SNAP-25 Regulates Secretion through Nonconservative Substitutions in the SNARE Domain". Molecular Biology of the Cell 16 12 (2005): 5675-5685. http://dx.doi.org/10.1091/mbc.e05-07-0595.
    Open access • Published • 10.1091/mbc.e05-07-0595
  42. Milosevic, I.. "Plasmalemmal Phosphatidylinositol-4,5-Bisphosphate Level Regulates the Releasable Vesicle Pool Size in Chromaffin Cells". Journal of Neuroscience 25 10 (2005): 2557-2565. http://dx.doi.org/10.1523/jneurosci.3761-04.2005.
    Published • 10.1523/jneurosci.3761-04.2005
Preprint
  1. Carvalho, Ana Luisa; Rodrigues, Beatriz; Leitão, Ricardo; Santos, Mónica; Trofimov, Alexander; Silva, Mariline; Inácio, Ângela; et al. "MiR-186-5p inhibition restores synaptic transmission and neuronal network activity in a model of chronic stress". 2023. http://dx.doi.org/10.21203/rs.3.rs-3405749/v1.
    10.21203/rs.3.rs-3405749/v1
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/02 Improving synaptic transmission in the failing brain INGRAM seminars
University of Kent (Canterbury, United Kingdom)
2022/12 Regulation of synaptic vesicle acidification 2022 UK Membrane Trafficking Meeting
University College London (London, United Kingdom)
2022/11 Improving organellar acidification in neurons undergoing neurodegeneration Parkinson's Research Day
University of Oxford (Oxford, United Kingdom)
2022/10 Towards improving synaptic transmission in the ageing mammalian brain RESET Ageing
University of Newcastle (Newcastle, United Kingdom)
2022/09 Towards improving organelle acidification and synaptic vesicle filling HDBMB-22
Croatian Society of Biochemistry and Molecular Biology (Brela, Croatia)
2022/07 From chromaffin cells to neurons: how to improve secretory vesicle acidification 21st International Symposium on Chromaffin Cell Biology (ISCCB-21)
ISCCB (Hamburg, Germany)
2022/05 Novel mechanisms of vertebrate v-ATPase activity regulation EMBO workshop Autophagy in brain health and disease
EMBO (Sant Feliu de Guixols, Spain)
2022/05 Towards improving synaptic transmission in the failing brain 8th Conference of the Mediterranean Neuroscience Society (MNS)
Mediterranean Neuroscience Society (MNS) (Dubrovnik, Croatia)
2022/04 Negative regulation of exocytosis by amisyn/STXBP6 39th IUPS Congress
(Beijing, China)
2020 20th International Symposium on Chromaffin Cell Biology (ISCCB-20), IIT Madras, Chennai, India 20th International Symposium on Chromaffin Cell Biology (ISCCB-20), IIT Madras, Chennai, India
2019 Society for Neuroscience (SfN) 2019 Annual Meeting
2019 Janelia/HHMI Conference: Cell Biology of Neurons and Circuits Janelia/HHMI Conference: Cell Biology of Neurons and Circuits
2019 7th Mediterranean Neuroscience Society (MNS) Conference 7th Mediterranean Neuroscience Society (MNS) Conference
2019 Biophysical Society: Quantitative aspects of membrane fusion and fission, 05/2019, Padova, Italy
2019 Biophysical Society Annual Meeting, Exocytosis & Endocytosis, 03/2019, Baltimore, MD, USA
2019 German Neuroscience Society (NWG) Biannual Meeting, Symposium on Neurodegenerative diseases: shaping neuronal circuits by membrane trafficking, 03/2019, Göttingen, Germany
2018 CAJAL Neuroscience Advanced Imaging Course (FENS/IBRO course), 09/2018, Bordeaux, France
2018 Utrecht Summer School: Neural Circuit Development and Plasticity, 07/2018, Utrecht, Netherlands
2018 GRC Conference: Cell Biology of the Neuron, 06/2018, Waterville Valley, NH, USA
2017 Frontiers in Hearing Research - Shanghai Forum, 12/2017; Shanghai, China
2017 Janelia/HHMI Conference: Cell Biology of Neurons and Circuits, 09/2017, Ashburn, VA, USA
2017 EMBO Conference Endocytic trafficking and signalling in health & disease, 09/2017, Serlock, Poland
2016 18th International Neuroscience Winter Conference, 04/2016, Sölden, Austria
2015 CAJAL Neuroscience Training Courses (FENS/IBRO course), 10/2015, Bordeaux, France

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/04 - 2022/09 Studying the Role of Rabconnectin 3a in Lysosomal Acidification and Lysosomal Function
Supervisor of Rachinnth Ravichandran
 MSc in Pharmacology (Master)
University of Oxford Department of Pharmacology, United Kingdom
2022/04 - 2022/09 Studies of Rabconnectin-3a protein structure
Supervisor of Mohammad Uzzal Hossain
 MSc in Pharmacology (Master)
University of Oxford Department of Pharmacology, United Kingdom
2022/04 - 2022/09 Links between Rabconnectin-3a and cell proliferation, glucose metabolism and mitochondria
Supervisor of Onyeka Awunor
 MSc in Pharmacology (Master)
University of Oxford Department of Pharmacology, United Kingdom
2018 - 2022/04/01 Characterization of neuronal SNARE protein amisyn and its role in neurotransmission
Supervisor of Dr. Jialin Jin
 GGNB, https://www.uni-goettingen.de/en/56640.html (PhD)
Georg-August-Universität Göttingen, Germany
2018 - 2021/11/04 Development of a versatile microfluidic platform to study the ionic mechanisms of vesicular neurotransmitter transporters
Co-supervisor of Dr Helena Maria Olsthoorn
 Neuroscience (PhD)
Georg-August-Universität Göttingen, Germany
2015 - 2020/01/10 Morphological Studies of Synaptic Vesicle Recycling at the Inner Hair Cell Ribbon Synapse
Supervisor of Dr Jana Kroll
 GGNB - Sensory and Motor Neuroscience, https://www.uni-goettingen.de/en/sh/58713.html (PhD)
Georg-August-Universität Göttingen, Germany
2019 - 2020 Characterization of amisyn expression and localization in the brain over mouse lifespan
Supervisor of Joana Pires
 Biomedicine (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - 2020 CHARACTERIZATION OF PROTEIN AND TRANSCRIPT LEVELS IN AMISYN MUTANT MICE
Supervisor of JOANA SOFIA LOPES FERREIRA
 Biomedicine (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - 2020 The role of Rabconnectin-3ß regulation in mTORC1 and autophagy
Supervisor of Joana Brandão Moreira
 Biomedicine (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2019 - 2020 Study of the role of Rabconnectin-3a at the auditory hair cell ribbon synapse
Supervisor of Mariana Moreira
 Biomedicine (Master)
Universidade de Aveiro Departamento de Ciências Médicas, Portugal
2015 - 2019/11/19 Mechanisms of regulation of mitochondria-endoplasmic reticulum contact sites
Co-supervisor of Dr. Renata Lopes Familiar Couto
 Cell Biology (PhD)
Georg-August-Universität Göttingen, Germany
2015 - 2019/10/25 Onset and Progression of Neurodegeneration in Mouse Models for Defective Endocytosis
Supervisor of Dr. Christine Melina Rostosky
 GGNB in Sensory and Motor Neuroscience, https://www.uni-goettingen.de/en/sh/58713.html (PhD)
Georg-August-Universität Göttingen, Germany
2016 - 2019/05/17 Using cell type-specific methods to understand molecular processes in the brain
Co-supervisor of Dr. Ashish Rajput
 Neuroscience (PhD)
Georg-August-Universität Göttingen, Germany
2018 - 2019 Measuring the transmembrane potential of lysosomes using a novel single vesicle assay
Supervisor of Daniel Alberto Giraldo Isaza
 Molecular Medicine MSc Program (Master)
Georg-August-Universität Göttingen, Germany
2014 - 2018/11/15 Lysosomal and mitochondrial crosstalk: the role of lysosomal signalling on mitochondrial biogenesis and function
Supervisor of Dr. King Faisal Yambire
 International Max Planck Research School (IMPRS) in Neuroscience (PhD)
Georg-August-Universität Göttingen, Germany
2017 - 2018 The role of molecular chaperones and ATP in protein aggregation in Saccharomyces cerevisiae during metabolic stress
Supervisor of Udhaya Bhaskar Sathya Narayanan
 Faculty of Biology, MSc Program (Master)
Georg-August-Universität Göttingen, Germany
2017 - 2018 Characterization of lipid binding properties of the E3-ubiquitin ligase Fbxo32
Co-supervisor of Nikhil Kalra
 MSc in Chemical and Bioprocess Engineering, TU Hamburg (Master)
Technische Universität Hamburg, Germany
2014 - 2018 Molecular mechanisms of synaptic vesicle recycling with a focus on Endophilin A and Rabconnectin-3a
Supervisor of Dr. Sindhuja Gowrisankaran
 International Max Planck Research School (IMPRS) in Neuroscience (PhD)
Georg-August-Universität Göttingen, Germany
2016 - 2017 Links between defective endocytosis and mitochondria
Co-supervisor of Katarzyna Wieciorek
 Mestrado Integrado em Engenharia Biomédica e Biofísica, with Prof. Alexandre Andrade (Master)
Fundação da Faculdade de Ciências da Universidade de Lisboa, Portugal
2014 - 2016 Studies of clathrin-coated vesicle acidification
Supervisor of Matija Krunic
 IMPRS Neuroscience (Master)
Georg-August-Universität Göttingen, Germany
2014 - 2015 The impact of endophilin-A on large dense core vesicle dynamics in neurosecretory cells
Supervisor of Vicky Steubler
 MSc Program in Developmental Biology (Master)
Georg-August-Universität Göttingen, Germany
2014 - 2015 The role of endophilin-A in trafficking of pro-survival molecules and FBXO32-induced cell death
Supervisor of Siona Freytag
 Program in Developmetal Biology (Master)
Georg-August-Universität Göttingen, Germany
2014/01 - 2014/06 Development of molecular tools to study the role of Rabconnectin-3a in synaptic vesicle recycling and membrane trafficking
Supervisor of Sindhuja Gowrisankaran
 IIMPRS in Neuroscience (Master)
Georg-August-Universität Göttingen, Germany
2013 - 2014 THE CELLULAR BASIS OF EPILEPSY IN MICE WITH PARTIAL ENDOPHILIN FUNCTION
Supervisor of Pratibha Narayanan
 IMPRS Neuroscience - 2014 (Master)
Georg-August-Universität Göttingen, Germany

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2019 - Current 3nd Organelle Network Mini-Symposium (2019 - 2019)
2023/06/26 - 2023/07/07 EIT Health Advanced course - Ageing: from fundamental biology to societal impact (2023/06/26 - 2023/07/07)
Workshop (Co-organisor)
2022/10/20 - 2022/10/21 8TH EUROPEAN SYNAPSE MEETING – COIMBRA 2022, https://esm-coimbra2022.cnc.uc.pt/ (2022/10/20 - 2022/10/21)
Conference (Co-organisor)
2022/06/27 - 2022/07/08 EIT Health Advanced course - Ageing: from fundamental biology to societal impact (2022/06/27 - 2022/07/08)
Workshop (Co-organisor)
2019 - 2019 ELECTRAIN: FENS Advanced Course in Electrophysiology (2019 - 2019)
2019 - 2019 Mitochondria in Neurodegeneration’ Symposium within the German Neuroscience Society (NWG) Biannual Meeting (2019 - 2019)
2019 - 2019 10th Schram Symposium ‘The mammalian brain: development and function’ (2019 - 2019)
2018 - 2018 2nd Organelle Network Mini-Symposium Goettingen (2018 - 2018)
2018 - 2018 ELECTRAIN: FENS course in electrophysiology, Göttingen (2018 - 2018)
2018 - 2018 Inter-organelle Communication and Neurodegeneration Symposium, Split, Croatia (2018 - 2018)
2016 - 2016 Synapses, Circuits and Sensory Systems Symposium, Göttingen (2016 - 2016)
2016 - 2016 1st Organelle Network Symposium; Göttingen (2016 - 2016)
2004 - 2004 1st Neurizons: Interdisciplinary PhD Symposium (2004 - 2004)

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2019 GGNB Goettingen J. Kroll (PhD)
2019 GGNB Goettingen R. Couto (PhD)
2018 GAUSS Goettingen A. Rajput (PhD)
2018 GGNB Goettingen C. Rostosky (PhD)
2018 GAUSS Goettingen C. Masaracchia (PhD)
2018 IMPRS Goettingen S. Gowrisankaran (PhD)
2017 GAUSS Goettingen K. Bersch (PhD)
2017 GGNB Goettingen L. Fernandez-Mosquera (PhD)
2017 IMPRS Goettingen K. F. Yambire (PhD)
2015 Free University of Amsterdam J. Kurps (PhD)
2015 IMPRS Goettingen Z. Farsi (PhD)
2015 CMPB Goettingen L. Cui (PhD)
2013 GGNB-Goettingen S. Chang (PhD)
2013 CMPB Goettingen X. Huang (PhD)
2013 IMPRS Goettingen Z. Jing (PhD)

Committee member

Activity description
Role 		Institution / Organization
2022 - Current Wellcome Centre for Human Genetics General Purpose Committee, University of Oxford
Member
 University of Oxford, United Kingdom
2022 - Current British Society for Research on Ageing (BSRA) Board of Trustees member
Member
 British Society for Research on Ageing, United Kingdom
2014/01 - Current International Max Planck Research School (IMPRS) in Neuroscience MSc & PhD admission panels
Member
 International Max Planck Research School (IMPRS) in Neuroscience, Germany
2014/01 - 2018/01 Göttingen Graduate Center for Neurosciences, Biophysics, and Molecular Biosciences (GGNB) Sensory and Motor Neuroscience (SMN) panel admission member https://www.uni-goettingen.de/en/58713.html
Member
 Georg-August-Universität Göttingen Universitätsmedizin, Germany
2014/01 - 2014/12 Speaker of ENI group leaders within European Neuroscience Institute Board of Directors
Member
 Europäisches Neurowissenschaftliches Institut Göttingen, Germany

Conference scientific committee

Conference name Conference host
2022/04/04 - 2022/04/08 Spring Ageing School and Symposium University of Coimbra

Evaluation committee

Activity description
Role 		Institution / Organization Funding entity
2022 - Current Deutsche Forschungsgemeinschaft (DFG) grant evaluator
Evaluator
 Deutsche Forschungsgemeinschaft, Germany Deutsche Forschungsgemeinschaft
2020/01 - Current Biotechnology and Biological Sciences Research Council (BBSRC) grant evaluator
Evaluator
 Biotechnology and Biological Sciences Research Council, United Kingdom Biotechnology and Biological Sciences Research Council
2020 - Current Wellcome Trust, for Sir Henry Dale Fellowships
Evaluator
 Wellcome Trust, United Kingdom Wellcome Trust
2018 - Current Austrian Academy of Science - PhD Fellowship Program, Vienna, Austria
Evaluator
 Österreichische Akademie der Wissenschaften, Austria Österreichische Akademie der Wissenschaften
2018 - Current Alzheimer's Research UK
Evaluator
 Alzheimer's Research Trust, United Kingdom Alzheimer's Research Trust
2018 - Current Fondation pour la Recherche Médicale grant evaluator
Evaluator
 Fondation pour la Recherche Médicale, France Fondation pour la Recherche Médicale
2017 - 2020 European Neuroscience Institute - Group Leader Job Search Committee
Evaluator
 Europäisches Neurowissenschaftliches Institut Göttingen, Germany

Journal scientific committee

Journal title (ISSN) Publisher
2020 - Current Cellular and Molecular Life Sciences (1420-9071) Springer-Verlag
2019 - Current Science (0036-8075) American Association for the Advancement of Science (AAAS)
2018 - Current Frontiers in Molecular Neuroscience (1662-5099) Frontiers Media SA
2018 - Current Cell Reports (2211-1247) Elsevier
2017 - Current Frontiers in Neuroscience (1662-453X) Frontiers Media SA
2017 - Current Molecular Neurodegeneration (1750-1326) Springer (Biomed Central Ltd.)
2016 - Current Scientific Reports (2045-2322) Springer Science and Business Media LLC
2015 - Current Journal of Neuroscience Methods (0165-0270) Elsevier
2012 - Current Journal of Neuroscience (1529-2401) Society for Neuroscience
2012 - Current Traffic (1600-0854) Wiley (Blackwell Publishing)
Distinctions

Award

2022 Wellcome Trust Investigator Award in Science
Wellcome Trust, United Kingdom
2020 John Black Senior Research Fellowship
2014 Synaptic Systems Award
2013 Emmy Noether Young Investigator Award
2011 Federation of European Biochemical Societies (FEBS) Anniversary Prize
Federation of European Biochemical Societies, United Kingdom
2007 European Molecular Biology Organization (EMBO) Postdoctoral Fellowship
Gesellschaft zur Förderung der Lebenswissenschaften Heidelberg GmbH, Germany
2003 Boehringer Ingelheim Fond (B.I.F.) Fellowship
2000 Chancellor’s Award for the Year 2000, University of Zagreb, Zagreb, Croatia

Other distinction

2014 AcademiaNet: Database of Leading Women Scientists