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Maria João Nunes Vicente Mexia Leitão. Concluiu o(a) Mestrado em Masters in Biomedical Research em 2011 pelo(a) Universidade de Coimbra Faculdade de Medicina e Licenciatura em Análises Clínicas e Saúde Pública em 2009/07 pelo(a) Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra. Frequenta o(a) Doutoramento em Programa Doutoral em Biologia Experimental e Biomedicina pelo(a) Universidade de Coimbra Centro de Neurociências e Biologia Celular desde 2016/10. Publicou 22 artigos em revistas especializadas. Participa e/ou participou como Bolseiro de Doutoramento em 1 projeto(s), Bolseiro de Gestão de Ciência e Tecnologia em 1 projeto(s), Bolseiro de Investigação em 2 projeto(s) e Outra em 1 projeto(s). Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Medicina Básica com ênfase em Neurociências e Ciências Médicas e da Saúde. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Health Sciences - Neurosciences; Alzheimer's disease; Parkinson's disease; cerebrospinal fluid; .
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Identification

Personal identification

Full name
Maria João Nunes Vicente Mexia Leitão

Citation names

  • Leitão, Maria João

Author identifiers

Ciência ID
F716-297F-1E1B
ORCID iD
0000-0002-8950-1439

Knowledge fields

  • Medical and Health Sciences - Basic Medicine - Neurosciences
  • Medical and Health Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
Portuguese Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
English Advanced (C1) Advanced (C1) Advanced (C1) Advanced (C1)
Spanish; Castilian Intermediate (B1) Intermediate (B1) Intermediate (B1) Intermediate (B1)
German Beginner (A1) Beginner (A1) Beginner (A1) Beginner (A1)
Education
Degree Classification
2016/10 - 2022
Ongoing
 Programa Doutoral em Biologia Experimental e Biomedicina (Doutoramento)
Major in Neurociências
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
"Neurociência" (THESIS/DISSERTATION)
2011
Concluded
 Masters in Biomedical Research (Mestrado)
Universidade de Coimbra Faculdade de Medicina, Portugal
"Identification of predictive molecular markers for disease progression and response to therapy in Monoclonal Gammopathies" (THESIS/DISSERTATION)
 16
2009/07
Concluded
 Análises Clínicas e Saúde Pública (Licenciatura)
Instituto Politécnico de Coimbra Escola Superior de Tecnologia da Saúde de Coimbra, Portugal
"n/a" (THESIS/DISSERTATION)
 13
Affiliation

Other Careers

Category
Host institution 		Employer
2012/01/02 - 2013/01/02 Técnico de 2ª Classe (Técnico de Diagnóstico e Terapêutica - Técnico de Análises Clínicas e de Saúde Pública) Laboratórios Beatriz Godinho, Portugal

Others

Category
Host institution 		Employer
2017/07/01 - 2021/06/01 PhD student (Doctoral Programme in Biomedicine and Experimental Biology) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2015/06/01 - 2017/06/01 BIM- Research Fellowship "Age related macular degeneration and Alzheimer's disease- research pathogenic common features (FMUC-AIBILI project) Universidade de Coimbra Faculdade de Medicina, Portugal
Universidade de Coimbra, Portugal
2014/01/31 - 2015/01/31 BIM-Research Fellow in European FCT/JPND/0001/2011 DEMTEST project- "Optimization of diagnostic tools for rapidly progressive dementias" Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2013/01/31 - 2014/01/31 BIM-Research Fellow in European FCT/JPND/0005/2011 BIOMARKAPD project- "Biomarkers for Alzheimer's disease and Parkinson's disease" Fundação para a Ciência e a Tecnologia, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Projects

Contract

Designation Funders
2017/07/01 - 2021/07/01 Emerging Multiple Sclerosis therapies to the test: tracking immune cell trafficking, induced molecular mechanisms and aftermath effects¿.
GZ-2017-11730
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2016/01 - 2016/12 The genetic Frontotemporal Dementia Initiative)- multicentre platform for the study of frontotemporal lobar degeneration (FTLD)
GENFI
Other
University College London Department of Clinical Neurosciences, United Kingdom
 UK Medical Research Council
Ongoing
2014/01/31 - 2015/01/31 DEMTEST (FCT/JPND- European project)- Biomarker based diagnosis of rapid progressive dementias - optimisation of diagnostic protocols
JPND/0001/2011
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
2013/01/31 - 2014/01/31 BIOMARKAPD (FCT/JPND project): Biomarkers for Alzheimer's disease and Parkinson's disease
FCT-JPND/0005/2011 project
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded

Other

Designation Funders
2015/06/02 - 2017/06/02 Degenerescência macular relacionada com a idade e Défice cognitivo/ Doença de Alzheimer: investigação de uma associação epidemiológica e patogénica
Degenerescência macular relacionada com a idade e Défice cognitivo/ Doença de Alzheimer: investigação de uma associação epidemiológica e patogénica
Science and Technology Management Fellow
Universidade de Coimbra Faculdade de Medicina, Portugal
 Universidade de Coimbra Faculdade de Medicina
Concluded
Outputs

Publications

Conference abstract
  1. Leitão, Maria. "“Inclusion of a-synuclein in a profile of CSF biomarkers to distinguish Lewy Body Dementia from Alzheimer's Disease patients”". 2015.
  2. Leitão, Maria. ""Quantification of protein 14-3-3gamma by ELISA improves Western Blot based diagnosis of sCJD cases"". 2015.
  3. Leitão, Maria. "“Added value of CSF Tau protein in diagnosis of sCJD suspected cases with a borderline 14-3-3 result”". 2014.
  4. Leitão, Maria. "“BIOMARKAPD European Project- task D3 achieved goals”". 2014.
Conference poster
  1. Leitao, M. J.; Pascoal, R.; Ribeiro, M. H.; Correia, I.; Batista, S.; Sousa, L.; Baldeiras, I.. "CSF neurofilament light chain provides a valuable prognostic tool in multiple sclerosis". Paper presented in ECTRIMS 2017- Paris, 2017.
    10.26226/MORRESSIER.59A3E8B6D462B8028D895028
  2. Leitão, Maria. "Polymorphism of MMP-9 gene in patients with multiple sclerosis". 2015.
  3. Leitão, Maria. ""Pattern of oligoclonal IgG bands in patients with multiple sclerosis"". 2015.
  4. Leitão, Maria João; Leitão, Maria. ""Óxido nítrico y ácido úrico como marcadores de estrés oxidativo en la esclerosis múltiple"". 2015.
Journal article
  1. Le Blanc, Gabriella; Jetté Pomerleau, Vincent; McCarthy, Jillian; Borroni, Barbara; van Swieten, John; Galimberti, Daniela; Sanchez-Valle, Raquel; et al. "Faster Cortical Thinning and Surface Area Loss in Presymptomatic and Symptomatic C9orf72 Repeat Expansion Adult Carriers". Annals of Neurology (2020): http://dx.doi.org/10.1002/ana.25748.
    Published • 10.1002/ana.25748 • Assistant staff
  2. Fernandes, C. Sousa; Pereira, M.; Cunha, I.; Duraes, J.; Duro, D.; Lima, M.; Gens, H.; et al. "CSF/serum glucose ratio in Frontotemporal Dementia". European Journal of Neurology (2020): https://publons.com/publon/34047206/.
  3. Antunes Cunha, I.; Tabuas Pereira, M.; Fernandes, C.; Maia, C.; Duraes, J.; Duro, D.; Gens, H.; et al. "Blood-brain barrier dysfunction in Alzheimer's disease is different in female and male patients". European Journal of Neurology (2020): https://publons.com/publon/34047205/.
  4. Moore, Katrina; Convery, Rhian; Bocchetta, Martina; Neason, Mollie; Cash, David M.; Greaves, Caroline; Russell, Lucy L.; et al. "A modified Camel and Cactus Test detects presymptomatic semantic impairment in genetic frontotemporal dementia within the GENFI cohort". Applied Neuropsychology: Adult (2020): https://publons.com/publon/30502116/.
    10.1080/23279095.2020.1716357
  5. Moore, Katrina M.; Nicholas, Jennifer; Grossman, Murray; McMillan, Corey T.; Irwin, David J.; Massimo, Lauren; Van Deerlin, Vivianna M.; et al. "Age at symptom onset and death and disease duration in genetic frontotemporal dementia: an international retrospective cohort study". The Lancet Neurology (2020): https://publons.com/publon/28390922/.
    10.1016/S1474-4422(19)30394-1
  6. Rhian S Convery; Martina Bocchetta; Caroline V Greaves; Katrina M Moore; David M Cash; John Van Swieten; Fermin Moreno; et al. "Abnormal pain perception is associated with thalamo-cortico-striatal atrophy in C9orf72 expansion carriers in the GENFI cohort". Journal of Neurology, Neurosurgery & Psychiatry (2020): https://publons.com/publon/33618848/.
    10.1136/JNNP-2020-323279
  7. Fernandes, Andreia; Tabuas-Pereira, Miguel; Duro, Diana; Lima, Marisa; Gens, Helena; Santiago, Beatriz; Duraes, Joao; et al. "C-reactive protein as a predictor of mild cognitive impairment conversion into Alzheimer's disease dementia". Experimental Gerontology (2020): https://publons.com/publon/32878502/.
    10.1016/J.EXGER.2020.111004
  8. Tábuas-Pereira, Miguel; Durães, João; Lopes, Joana; Sales, Francisco; Bento, Conceição; Duro, Diana; Santiago, Beatriz; et al. "Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer's disease". Epilepsy & Behavior 98 (2019): 207-209. http://dx.doi.org/10.1016/j.yebeh.2019.06.033.
    Published • 10.1016/j.yebeh.2019.06.033
  9. Premi, Enrico; Calhoun, Vince D.; Diano, Matteo; Gazzina, Stefano; Cosseddu, Maura; Alberici, Antonella; Archetti, Silvana; et al. "The inner fluctuations of the brain in presymptomatic Frontotemporal Dementia: The chronnectome fingerprint". NeuroImage 189 (2019): 645-654. http://dx.doi.org/10.1016/j.neuroimage.2019.01.080.
    Published • 10.1016/j.neuroimage.2019.01.080 • Assistant staff
  10. Vieira, Daniela; Duraes, Joao; Baldeiras, Ines; Santiago, Beatriz; Duro, Diana; Lima, Marisa; Leitao, Maria Joao; et al. "Lower CSF Amyloid-Beta(1-42) Predicts a Higher Mortality Rate in Frontotemporal Dementia". Diagnostics 9 4 (2019): 162. https://publons.com/publon/31332874/.
    Published • 10.3390/DIAGNOSTICS9040162
  11. Sudre, Carole H.; Bocchetta, Martina; Heller, Carolin; Convery, Rhian; Neason, Mollie; Moore, Katrina M.; Cash, David M.; et al. "White matter hyperintensities in progranulin-associated frontotemporal dementia: A longitudinal GENFI study". NeuroImage: Clinical (2019): https://publons.com/publon/28970879/.
    10.1016/J.NICL.2019.102077
  12. Sousa Fernandes, C.; Baldeiras, I.; Guerreiro, R.; Ribeiro, J. A.; Cunha, R.; Youngstein, T.; Nanthapisal, S.; et al. "Plasma adenosine deaminase 2 and serum immunoglobulin M accuracy in adult Sneddon's syndrome". European Journal of Neurology (2019): https://publons.com/publon/30581943/.
  13. Duraes, J.; Tabuas-Pereira, M.; Baldeiras, I.; Leitao, M. J.; Gens, H.; Duro, D.; Santiago, B.; Oliveira, C.; Santana, I.. "Lower amyloid-beta levels predict a more aggressive course in frontotemporal dementia". European Journal of Neurology (2019): https://publons.com/publon/31333135/.
  14. Santo, Gustavo C.; Baldeiras, Inês; Guerreiro, Rita; Ribeiro, Joana A.; Cunha, Rosário; Youngstein, Taryn; Nanthapisal, Sira; et al. "Adenosine Deaminase Two and Immunoglobulin M Accurately Differentiate Adult Sneddon’s Syndrome of Unknown Cause". Cerebrovascular Diseases 46 5-6 (2018): 257-264. http://dx.doi.org/10.1159/000495794.
    Published • 10.1159/000495794
  15. Valado, Ana; Leitao, Maria Joao; Martinho, Antonio; Pascoal, Rui; Cerqueira, Joao; Correia, Ines; Batista, Sonia; et al. "Multiple sclerosis: Association of gelatinase B/matrix metalloproteinase-9 with risk and clinical course the disease". Multiple Sclerosis and Related Disorders 11 (2017): 71-76. https://publons.com/publon/9092059/.
    Published • 10.1016/J.MSARD.2016.12.003
  16. Leitão, M.J.; Baldeiras, I.; Almeida, M.R.; Ribeiro, M.H.; Santos, A.C.; Ribeiro, M.; Tomás, J.; et al. "Sporadic Creutzfeldt–Jakob disease diagnostic accuracy is improved by a new CSF ELISA 14-3-3¿ assay". Neuroscience 322 (2016): 398-407. http://dx.doi.org/10.1016/j.neuroscience.2016.02.057.
    10.1016/j.neuroscience.2016.02.057
  17. Leito, M. J.; Baldeiras, I.; Almeida, M. R.; Ribeiro, M. H.; Santos, A. C.; Ribeiro, M.; Tomas, J.; et al. "CSF Tau proteins reduce misdiagnosis of sporadic Creutzfeldt-Jakob disease suspected cases with inconclusive 14-3-3 result". Journal of Neurology 263 9 (2016): 1847-1861. https://publons.com/publon/12396708/.
    Published • 10.1007/S00415-016-8209-X
  18. Miguel Tábuas-Pereira; Inês Baldeiras; Diana Duro; Beatriz Santiago; Maria Ribeiro; Maria Leitão; Catarina Oliveira; et al. "Prognosis of Early-Onset vs. Late-Onset Mild Cognitive Impairment: Comparison of Conversion Rates and Its Predictors". Geriatrics (Basel, Switzerland) 1 2 (2016): 11. https://publons.com/publon/34047254/.
    Published • 10.3390/GERIATRICS1020011
  19. Santana, I.; Baldeiras, I.; Duro, D.; Tabuas-Pereira, M.; Leitao, M. J.; Lemos, R.; Oliveira, C.; Freitas, S.. "Montreal Cognitive Assessment in mild cognitive impairment: correlation with cerebral spinal fluid biomarkers and prediction of conversion to dementia". European Journal of Neurology (2016): https://publons.com/publon/34047208/.
  20. Leitao, M. J.; Baldeiras, I.; Almeida, M. R.; Ribeiro, M. H.; Santos, A. C.; Ribeiro, M.; Tomas, J.; et al. "SPORADIC CREUTZFELDT-JAKOB DISEASE DIAGNOSTIC ACCURACY IS IMPROVED BY A NEW CSF ELISA 14-3-3 gamma ASSAY". Neuroscience (2016): https://publons.com/publon/12396706/.
    10.1016/J.NEUROSCIENCE.2016.02.057
  21. Baldeiras, Ines; Santana, Isabel; Leitao, Maria Joao; Ribeiro, Maria Helena; Pascoal, Rui; Duro, Diana; Lemos, Raquel; et al. "Cerebrospinal fluid A beta 40 is similarly reduced in patients with Frontotemporal Lobar Degeneration and Alzheimer's Disease". Journal of the Neurological Sciences 358 1-2 (2015): 308-316. https://publons.com/publon/12396709/.
    Published • 10.1016/J.JNS.2015.09.022
  22. Leitao, Maria Joao; Baldeiras, Ines; Herukka, Sanna-Kaisa; Pikkarainen, Maria; Leinonen, Ville; Simonsen, Anja Hviid; Perret-Liaudet, Armand; et al. "Chasing the effects of pre-analytical confounders - a multicenter study on CSF-AD biomarkers". Frontiers in Neurology (2015): https://publons.com/publon/3367624/.
    10.3389/FNEUR.2015.00153
Activities

Consulting

Activity description Institution / Organization
2015 - 2016 Suporte técnico no projecto Europeu GENFI (The genetic Frontotemporal Dementia Initiative)- multicentre platform for the study of frontotemporal lobar degeneration (FTLD), leaded by the University College London (UCL) Centro Hospitalar e Universitário de Coimbra EPE, Portugal

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2018/05 - Current Biomarcadores no Défice Cognitivo Ligeiro (Bial SummInt 2018) BIAL SummInt 2018 (Mestrado integrado) Laboratórios Bial, Portugal
2016/06 - Current JPND BIOMARKAPD course- "Biological markers in Neurological diseases- Present and Future approaches" "Biological markers in Neurological diseases- Present and Future approaches" (Outros) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal