Cristina Maria Godinho Pires João (F812-814B-AEED)

Curriculum Vitae

Cristina Maria Godinho Pires João

I am Dr. Cristina Maria Godinho Pires João, a seasoned hematologist currently practicing and conducting research at the Champalimaud Foundation since 2015. I earned my PhD in Medicine from Universidade Nova de Lisboa, Faculty of Medical Sciences, graduating with laude, praise, and distinction in 2008. My Degree in Medicine was obtained from Universidade de Lisboa, Faculty of Medicine, in 1996. I pursued doctoral studies and a master's in clinical research at Mayo Clinic, Rochester, MN, USA, from 2002 to 2006. Specializing in Clinical Hematology in 2008, I achieved a final classification of 19.9 out of 20. Since 2010, I have served as a tenured assistant professor of Immunology at the Faculty of Medical Sciences of Universidade Nova de Lisboa. I have authored 75 articles in specialized journals, accumulating over 800 citations in the last six years. I have supervised two doctoral theses, co-supervised one, and overseen three master's dissertations. Currently advising three doctoral students and one master's student, I lead the research group on Lymphomas and Multiple Myeloma at the Champalimaud Foundation. My current scientific endeavors focus on translational research in Hemato-Oncology, particularly in Multiple Myeloma. My research interests revolve around understanding the immune microenvironment of Multiple Myeloma (MM) and leveraging fundamental immunological concepts for clinical applications in hematological malignancies. My research spans from investigating the role of B cells and immunoglobulins in T cell development to exploring liquid biopsies as biomarkers in MM progression. I am also engaged in multi-omics approaches to elucidate MM aggressiveness and am developing a project integrating genomics, proteomics, and radiomics data. As principal investigator of several academic clinical trials and serving as PI in pharmaceutical company-sponsored trials, I am an active member of various professional societies, including the Portuguese Multiple Myeloma Group, the Portuguese Lymphoma Group, the International Working Group of Multiple Myeloma (IMWG), the Portuguese Society of Hematology, the European Society of Hematology, EATRIS (European Infrastructure for Translational Medicine), and EuROFLOW. I contribute my expertise to several IMWG working groups and have received nine prizes and/or honors for my contributions to the field.

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Identification

Personal identification

Full name: Cristina Maria Godinho Pires João

Citation names

Cristina João

Author identifiers

Ciência ID: F812-814B-AEED
ORCID iD: 0000-0002-3978-766X

Email addresses

cristina.joao@fundacaochampalimaud.pt (Professional)
cristina.joao@research.fchampalimaud.org (Professional)
cristina.joao@research.fchampalimaud.org (Personal)

Addresses

Fundação Champalimaud. Av Brasilia, 1044, Lisboa, Lisboa, Portugal (Professional)

Websites

https://www.fchampalimaud.org/researchfc/groups/grupo-myeloma-lymphoma (Professional)
https://www.fchampalimaud.org/centroclinicofc/unidades/hemato-oncologia (Professional)

Knowledge fields

Medical and Health Sciences - Clinical Medicine - Hematology
Medical and Health Sciences - Basic Medicine - Immunology
Medical and Health Sciences - Clinical Medicine - Oncology
Medical and Health Sciences - Clinical Medicine - Other Clinical Medicine Subjects

Languages

Language	Speaking	Reading	Writing	Listening
English	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
French	Beginner (A1)	Intermediate (B1)	Beginner (A1)	Beginner (A1)
Portuguese	Advanced (C1)	Advanced (C1)	Advanced (C1)	Advanced (C1)
Spanish; Castilian	Intermediate (B1)	Intermediate (B1)	Beginner (A1)	Intermediate (B1)

Education

	Degree	Classification
2008/02/22 - 2018/08/14 Concluded	Consultant Degree in Clinical Hematology (Outros) Major in Clinical Hematology ACSS- Administração Central do Sistema de Saude, Portugal	17/20
2008/03/04 Concluded	Master's in Biomedical Sciences, Clinical Investigation (Mestrado integrado) Major in Master's in Biomedical Sciences, Clinical Investigation Universidade Nova de Lisboa, Portugal "B cell dependent T cell development" (THESIS/DISSERTATION)	Approved
1998/01/02 - 2008/02/22 Concluded	Clinical Hematology Specialist (Título de especialista) Major in Clinical Hematology Ordem dos Médicos, Portugal	19,9/20
2008 Concluded	Medicine (Doutoramento) Major in Specialty: Internal Medicine Universidade NOVA de Lisboa NOVA Medical School, Portugal "Reconstituição do Reportório Imunológico em Contexto de Transplantação Hematopoiética / Reconstitution of the Immunological Repertoire in the Context of Hematopoietic Transplantation" (THESIS/DISSERTATION)
2004 - 2006 Concluded	Master in Clinical Research (Master) Major in Investigação Clinica Mayo Clinic Cancer Center, United States "B cell dependent T cell development" (THESIS/DISSERTATION)	Excelent
1997 - 1997 Concluded	Ensino prático - como fazer, como avaliar? / Practical teaching - how to do it, how to evaluate it? (Especialização pós-licenciatura) Major in Medical Education Universidade de Lisboa Faculdade de Medicina, Portugal	Apta
1997 - 1997 Concluded	Advances in Immunology (Especialização pós-licenciatura) Major in Imunologia Instituto Gulbenkian de Ciência, Portugal	Apta
1996/07 - 1996/08 Concluded	The 1st Copenhagen International Interdisciplinary School in Biological Science: "The spontaneous order of life - in search of the loss of self-organization in Physical, Biological and Cognitive Systems" (Postgraduate Certificate) Major in Biological Systems Københavns Universitet Niels Bohr Instituttet, Denmark	Pass
1990/09 - 1996/07/22 Concluded	Medicine (Licenciatura) Universidade de Lisboa Faculdade de Medicina, Portugal	18/20

Affiliation

Teaching in Higher Education

	Category Host institution	Employer
2010/02/01 - Current	Invited Assistant Professor (University Teacher)	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/09/01 - 2021/07/31	Lecturer (University Teacher)	Centro Hospitalar e Universitario de Coimbra EPE Campus dos Hospitais da Universidade de Coimbra, Portugal
	Centro Hospitalar e Universitario de Coimbra EPE Campus dos Hospitais da Universidade de Coimbra, Portugal
2019/10/14 - 2019/10/16	Lecturer (University Teacher)	Sociedade Portuguesa de Hematologia, Portugal
	Sociedade Portuguesa de Hematologia, Portugal
2016 - 2016	Visiting Professor (University Teacher)	Janssen Pharmaceuticals Inc, Hungary
	Janssen Pharmaceuticals Inc, Hungary
2011/09/01 - 2012/06/30	Invited Assistant (University Teacher)	Université Sorbonne Paris Nord UFR de Santé Médecine Biologie Humaine, France
	Université Sorbonne Paris Nord UFR de Santé Médecine Biologie Humaine, France
2007/10/01 - 2008/03/31	Invited Associate Professor (University Teacher)	Universidade de Lisboa Instituto de Medicina Preventiva e Saúde Pública, Portugal
	Universidade de Lisboa Instituto de Medicina Preventiva e Saúde Pública, Portugal (...)

Positions / Appointments

	Category Host institution	Employer
2023/11/01 - Current	Directors Board member of EuroFlow	EuroFlow, Netherlands

2023/11/01 - Current	Assembly secretary	Sociedade Portuguesa de Hematologia, Portugal

2021/12/01 - Current	Directors Board member of the Multiple Myeloma Group	Sociedade Portuguesa de Hematologia, Portugal

2019 - Current	Research Group Leader	Fundação Champalimaud, Portugal

2018/08/14 - Current	Hematologist Consultant	Fundação Champalimaud, Portugal

2015/01/01 - Current	Member of the Bone and Imaging Working Committee	International Myeloma Foundation, United States
	International Myeloma Working Group, United States
2015/01/01 - Current	Member of the Smouldering Multiple Myeloma Working Committee	International Myeloma Foundation, United States
	International Myeloma Working Group, United States

Others

	Category Host institution	Employer
2008/04/01 - 2015/05/01	Hematology Assistant (clinical responsabilities at the Hematology Department, IPO Lisboa)	Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
	Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal
2008/01/01 - 2015/05/01	Researcher (Principal Investigator, Scientific Research on Immune Reconstitution)	Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
	Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal
2009 - 2014	Principal Investigator	Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal

2006/06/01 - 2010/01/01	External Research Collaborator	Mayo Clinic Cancer Center, United States

1999/01/01 - 2008/03/01	Resident in Clinical Hematology (interrupted to PhD studies between 2003 and 2006)	Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal

2006 - 2008	Research Collaborator	Instituto Gulbenkian de Ciência, Portugal

2005 - 2006	External Post doctoral Research Fellow	Mayo Clinic Cancer Center, United States

2002/06 - 2005	Post doctoral Research Fellow	Mayo Clinic Cancer Center, United States

1997/01/01 - 1998/12/31	General Residency	Hospital Distrital De Santarém Epe, Portugal

1995/09/01 - 1997/07/01	Hired assistant of Histology and Embriology	Universidade de Lisboa Faculdade de Medicina, Portugal

Projects

Grant

	Designation	Funders
2022/10/02 - 2024/06/30	Study of the neuronal role on the interplay between NK cells and Multiple Myeloma (NeuriMM) Study of the neuronal role on the interplay between NK cells and Multiple Myeloma (NeuriMM) Principal investigator Fundação Champalimaud, Portugal	Associação Portuguesa Contra a Leucemia Sociedade Portuguesa de Hematologia Amgen - Bio - Farmacêutica, Lda Ongoing
2009/01 - 2012/06	Lupus and its compensation in unaffected relatives by T-cell regulation Provided by PTCRIS: 82746 Researcher	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2011	Assessment of T cell receptor diversity in different imbalance immunological conditions using CDR3 spectratyping FCT_ProgramaPessoa2010 Principal investigator Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal Instituto Gulbenkian de Ciência, Portugal Sorbonne Université Faculté de Médecine Campus Pitié-Salpêtrière, France	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2011	B cell modulation of T cells function and repertoire - immune characterization of lymphoma patients receiving chemotherapy with or without a B cell depleting agent, Rituximab APCL2007 Principal investigator Instituto Português de Oncologia de Lisboa Francisco Gentil EPE Unidade de Investigação em Patobiologia Molecular, Portugal	Associação Portuguesa contra a Leucemia Concluded
2007/09 - 2010/12	Quantitative and Qualitative T cell receptor repertoire requirements for immune tolerance establishment and maintenance Provided by PTCRIS: 71402 Researcher	Fundação para a Ciência e a Tecnologia
2002/07/01 - 2006/05/31	B cell-dependent T cell development and function SFRH/BD/6797/2001 Universidade NOVA de Lisboa NOVA Medical School, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2002 - 2006	Immune reconstitution after bone marrow transplantation SFRH/BD/6797/2001 PhD Student Fellow Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2001 - 2002	Cytogenetic abnormalities in MALT lymphomas GHOP_MALT Lymphomas2001 Principal investigator Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal	GHOP – Portuguese Group of Onco-Hematology Fellowship Concluded

Contract

	Designation	Funders
2020/11/25 - Current	Exploring the bone marrow microenvironment communication via extracellular vesicles in an immunocompetent multiple myeloma mouse models and its potential translation to human disease Refª - PGG/058/2019 Refª - PGG/058/2019 Principal investigator Fundação Champalimaud, Portugal	Gilead Sciences Lda Concluded
2019/07 - Current	LyRaCAD (Sistema CAD para análise de imagens PET/CT com 18F-FDG em linfomas – uma abordagem radiomics) POCI-01-0247-FEDER-039885 Researcher Fundação Champalimaud, Portugal	Horizon 2020 Ongoing
2019 - Current	Zebrafish avatar for CLL therapy screening Kickstarters 2019 Fundação Champalimaud, Portugal	Fundação Champalimaud Ongoing
2017 - Current	The role of metastatic microenvironment in Multiple Myeloma extramedullary disease (EMphAsIS) PTDC/MEC-HEM/30315/2017 Fundação Champalimaud, Portugal	Ongoing
2015 - Current	Phase 3 Randomized, Double-Blind, Placebo Controlled, Multicenter Study to Compare the Efficacy and Safety of Lenalidomide (CC-5013) Plus R-CHOP Chemotherapy (R2-CHOP) Versus Placebo Plus R-CHOP Chemotherapy in Subjects with Previously Untreated Activated B-cell Type Diffuse Large B-cell Lymphoma CC-5013-DLC-002 CC-5013-DLC-002 Researcher Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal	Celgene Portugal Ongoing
2023/11/01 - 2025/10/31	Identification of non-invasive genetic biomarkers predicting Daratumumab plus carfilzomib and dexamethasone response in Multiple Myeloma IIS RESEARCH SUPPORT APPLICATION INVESTIGATOR-INITIATED STUDY Co-Principal Investigator (Co-PI) Fundação Champalimaud, Portugal	Janssen Global Services LLC Ongoing
2022/01/01 - 2024/12/31	Unic.MM: Combined immunotherapy as a strategy for manipulating the bone marrow microenvironment in multiple myeloma PTDC/MED-ONC/1215/2021 10.54499/PTDC/MED-ONC/1215/2021 Principal investigator Fundação Champalimaud, Portugal Universidade Nova de Lisboa, Portugal Universidade Nova de Lisboa Centro de Toxicogenómica e Saúde Humana, Portugal Universidade de Lisboa Instituto de Medicina Molecular João Lobo Antunes, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016/11/04 - 2023/03/10	TOURMALINE - A Phase 3 Study Comparing Oral Ixazomib Plus Lenalidomide and Dexamethasone Versus Placebo Plus Lenalidomide and Dexamethasone in Adult Participants With Relapsed and/¿or Refractory Multiple Myeloma NCT01564537 Principal investigator Fundação Champalimaud, Portugal Takeda Global Research and Development Center Inc, United States	Takeda Global Research and Development Center Inc Concluded
2018/12/03 - 2022/07/01	EMphAsIS_The role of metastatic microenvironment in Multiple Myeloma extramedullary disease. FCT-PTDC/MEC-HEM/30315/2017 PTDC/MEC-HEM/30315/2017 Bolsa de Iniciação à Investigação da SPH - 2018 PTDC/MEC-HEM/30315/2017 Principal investigator Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia N/A Ongoing
2021/01/28 - 2021/03/10	Study of the neuronal role on the interplay between NK cells and Multiple Myeloma (NeuriMM) 2022.08762.PTDC Researcher Fundação Champalimaud, Portugal	Fundação para a Ciência e a Tecnologia Ongoing
2016 - 2018	Placebo-Controlled, Double-Blind Study of Oral Ixazomib Maintenance Therapy After Initial Therapy in Patients With Newly Diagnosed Multiple Myeloma Not Treated With Stem Cell Transplantation NCT02312258 Principal investigator Fundação Champalimaud, Portugal	Takeda Farmacêuticos Portugal Concluded
2013 - 2015	Open-label study with Pomalidomide in Combination with Low Dose Dexamethasone in subjects with Refractory or Relapsed and Refractory Multiple Myeloma CC-4047-MM-010 Principal investigator Celgene Portugal, Portugal	Celgene Portugal Concluded
2013 - 2015	A Randomized, Controlled, Open-Label, Multicenter Phase 3 Study of the Bruton’s Tyrosine Kinase (Btk) Inhibitor, Ibrutinib, versus Temsirolimus in Subjects with Relapsed or Refractory Mantle Cell Lymphoma Who Have Received At least One Prior Therapy NCT01646021 Principal investigator Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal	Janssen-Cilag Farmacêutica Lda Concluded
2011/03/15 - 2014/09/14	Chronic intermittent eucapnic hypoxia: systemic effects and assessment of the efficacy of antihypertensive drugs PTDC/SAU-TOX/112264/2009 Universidade NOVA de Lisboa NOVA Medical School, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal Universidad de Valladolid, Spain Instituto de Biologia Experimental e Tecnológica, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2010 - 2014	Randomized phase IIIb clinical trial of Mabthera (Rituximab) added to chemotherapy, Bendamustine or Chlorambucil, in patients with Chronic Lymphocytic Leukemia MO22468 Principal investigator Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal	Roche Farmaceutica Quimica Lda Concluded
2010 - 2013	Chronic Intermittent Eucapnic Hypoxia: systemic effects and evaluation of anti-hypertensive drugs efficacy PTDC/SAL-TOX/112264/2009 Provided by PTCRIS: 112264 Researcher Fundação para a Ciência e a Tecnologia, Portugal Universidade Nova de Lisboa Centro de Estudos de Doenças Crónicas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2009/01/01 - 2012/06/30	Lupus and its compensation in unaffected relatives by T cell regulation PIC/IC/82746/2007 Fundação Calouste Gulbenkian, Portugal Instituto Gulbenkian de Ciência, Portugal Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal Associacao de Doentes com Lupus, Portugal Hospital Geral de Santo António SA, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/09/01 - 2010/12/31	Repertoire of T cell receptors in the generation and maintenance of immunological tolerance: Qualitative and quantitative requirements. PTDC/SAU-MII/71402/2006 Researcher Fundação Calouste Gulbenkian, Portugal Instituto Gulbenkian de Ciência, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/09/01 - 2010/08/31	Immune reconstitution after Autologous Hematopoietic Stem Cell Transplantation - modulation by immunoglobulins and potential clinical application PTDC/SAU-MII/65029/2006 Principal investigator Fundação Calouste Gulbenkian, Portugal Instituto Gulbenkian de Ciência, Portugal Instituto Português de Oncologia de Lisboa Francisco Gentil EPE, Portugal Universidade de Trás-os-Montes e Alto Douro Centro de Investigação e de Tecnologias Agro-Ambientais e Biologicas, Portugal Institut Pasteur, France	Fundação para a Ciência e a Tecnologia Concluded
2007 - 2010	Lupus and its compensation in unaffected relatives by T-cell regulation PIC/IC/82746/2007 Researcher Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia Concluded
2007/09/01 - 2009	Immune recovery after Autologous Stem Cell Transplantation - modulation by Ig and potential clinical application 2006-30.4M.AP/MJ PTDC/SAU-MII/65029/2006 Provided by PTCRIS: 65029 Principal investigator Associação Portuguesa contra a Leucemia, Portugal Fundação para a Ciência e a Tecnologia, Portugal	Associação Portuguesa contra a Leucemia Fundação para a Ciência e a Tecnologia Concluded

Other

	Designation	Funders
2023/01/23 - Current	VOLTA project Projeto VOLTA Technical development
2023/01/01 - Current	CarMMa - Characterization of the Population of Patients with Multiple Myeloma Treated in Portuguese Hospitals and Characterization of Their Caregivers CarMMa Principal investigator	Ongoing
2023/06/02 - 2033/11/30	SUCCESSOR-1 - A Study to Evaluate Mezigdomide, Bortezomib and Dexamethasone (MEZIVd) Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) NCT05519085 Principal investigator Fundação Champalimaud, Portugal Celgene, United States	Celgene Ongoing
2022/10/17 - 2032/06/25	EXCALIBER-RRMM - Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM) NCT04975997 Principal investigator Celgene, United States Fundação Champalimaud, Portugal	Celgene Ongoing
2023/07/28 - 2031/08/31	MajesTEC-9 - A Study Comparing Teclistamab Monotherapy Versus Pomalidomide, Bortezomib, Dexamethasone (PVd) or Carfilzomib, Dexamethasone (Kd) in Participants With Relapsed or Refractory Multiple Myeloma NCT05572515 Principal investigator Janssen Research & Development, LLC, United States Fundação Champalimaud, Portugal	Janssen Research & Development, LLC Ongoing
2023/03/03 - 2027/04/06	MK-2140-006 - A Study of Zilovertamab Vedotin (MK-2140) as Monotherapy and in Combination in Participants With Aggressive and Indolent B-cell Malignancies NCT05458297 Principal investigator Fundação Champalimaud, Portugal Merck Sharp & Dohme Corp, United States	Merck Sharp & Dohme Corp
2021/12/03 - 2027/02/05	ESCALADE - A Combination of Acalabrutinib With R-CHOP in Subjects With Previously Untreated Non-GCB DLBCL (ACE-LY-312) NCT04529772 Principal investigator AstraZeneca Pharmaceuticals LP, United States Fundação Champalimaud, Portugal	AstraZeneca Pharmaceuticals LP Ongoing
2021/11/12 - 2026/11/01	CONPET - Intensified Treatment With Carfilzomib in Myeloma Patients Still PET-positive After First Line Treatment. NCT03314636 Principal investigator Oslo universitetssykehus, Norway Fundação Champalimaud, Portugal	Oslo universitetssykehus
2023/04/14 - 2026/04/27	IMPACTMF - A Study Comparing Imetelstat Versus Best Available Therapy for the Treatment of Intermediate-2 or High-risk Myelofibrosis (MF) Who Have Not Responded to Janus Kinase (JAK)-Inhibitor Treatment NCT04576156 Principal investigator Geron Corporation, United States Fundação Champalimaud, Portugal	Geron Corporation Ongoing
2021/10/26 - 2025/04/01	LOXO-BRUIN - Study of BTK Inhibitor LOXO-305 Versus Approved BTK Inhibitor Drugs in Patients With Mantle Cell Lymphoma (MCL) (BRUIN-MCL-321) NCT04662255 Principal investigator Loxo Oncology Inc, United States Fundação Champalimaud, Portugal	Loxo Oncology Inc Ongoing
2023/10/17 - 2024/07/17	ACT17453 - A Study to Investigate Subcutaneous Isatuximab in Combination With Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma NCT05704049 Principal investigator Fundação Champalimaud, Portugal Sanofi SA Research and Development Waltham, United States	Sanofi SA Research and Development Waltham Ongoing
2021/08/17 - 2023/12/29	CAS-OFLYRICLB - Evaluation of the Chronic Lymphoproliferative Diseases Limited Panel on the BD FACSLyric™ Flow Cytometer NCT05032313 Researcher Fundação Champalimaud, Portugal Becton, Dickinson and Company, United States	Becton, Dickinson and Company Cancelled
2022/07/29 - 2023/11/07	KRT232-101_BOREAS - KRT-232 Versus Best Available Therapy for the Treatment of Subjects With Myelofibrosis Who Are Relapsed or Refractory to JAK Inhibitor Treatment NCT03662126 Principal investigator Kartos Therapeutics, Inc., United States Fundação Champalimaud, Portugal	Kartos Therapeutics, Inc. Concluded
2021/10/22 - 2023/10/25	CAS-OFLYRICPP - Evaluation of the Plasma Cell Disorders Panel on the BD FACSLyric™ Flow Cytometer NCT05032339 Researcher Becton, Dickinson and Company, United States Fundação Champalimaud, Portugal	Becton, Dickinson and Company Concluded
2015/11/16 - 2023/10/04	ALCYONE - A Study of Combination of Daratumumab and Velcade (Bortezomib) Melphalan-Prednisone (DVMP) Compared to Velcade Melphalan-Prednisone (VMP) in Participants With Previously Untreated Multiple Myeloma NCT02195479 Principal investigator Fundação Champalimaud, Portugal Janssen Research and Development Belgium Discovery Process Research Group, Belgium	Janssen Research and Development Belgium Discovery Process Research Group Ongoing
2022/12/06 - 2023/09/01	CAS-OFLBT1T4 - BD OneFlow CLPD Panel (BD OneFlow LST and B-CLPD assays T1 to T4) in the BD FACSLyric System. NCT05557422 Researcher Fundação Champalimaud, Portugal Becton Dickinson and Company, United States	Becton Dickinson and Company Ongoing
2022/07/29 - 2023/06/30	KRT232-111 - Safety and Efficacy of KRT-232 in Combination With Acalabrutinib in Subjects With R/R DLBCL or R/R CLL NCT04502394 Principal investigator Fundação Champalimaud, Portugal Kartos Therapeutics, Inc., United States	Kartos Therapeutics, Inc. Concluded
2021/03/09 - 2023/04/28	MRDeep - Prevalence of minimal residual disease (MRD) in patients treated for Multiple Myeloma (MM) who reach complete response and are currently on 2nd or 3rd line of therapy for MM MRDEEP Principal investigator Janssen Global Services LLC, United States Fundação Champalimaud, Portugal	Janssen Global Services LLC
2020/05/04 - 2023/04/17	FIRST-MIND - Phase Ib Study to Assess Safety and Preliminary Efficacy of Tafasitamab or Tafasitamab Plus Lenalidomide in Addition to R-CHOP in Patients With Newly Diagnosed DLBCL NCT04134936 Principal investigator Fundação Champalimaud, Portugal MorphoSys AG, Germany	MorphoSys AG Concluded
2021/09/10 - 2023/01/30	ENHANCE - Phase I/II Trial of VELCADE + CHOP-Rituximab in Untreated DLCBL or Mantle Cell NHL NCT00151320 Principal investigator Cornell University Joan and Sanford I Weill Medical College, United States Fundação Champalimaud, Portugal	Cornell University Joan and Sanford I Weill Medical College Concluded
2019/08/02 - 2022/12/19	EMN23/54767414AMY0001 - A Retrospective Observational Multicenter Study on the Management and Outcome of Patients With Systemic AL Amyloidosis in Europe NCT04937777 Principal investigator European Myeloma Network, Netherlands Fundação Champalimaud, Portugal	European Myeloma Network Concluded
2017/09/01 - 2018/08/31	Atlas-based semi-automatic segmentation of Whole-Body DWI Images: Quantification of tumour burden Kickstarter Principal investigator Fundação Champalimaud, Portugal	Fundação Champalimaud Concluded

Outputs

Publications

Book chapter	João, Cristina. "Lymphomas". In The General and Family Medicine Manual. Portugal: Associação Portuguesa de Medicina Geral e Familiar, 2000. Published
Conference abstract	Constantino, Cláudia; Oliveira, Francisco; Leocádio, Sónia; Silva, Mariana; Carla Oliveira; Castanheira, Joana; Silva, Angelo; et al. Corresponding author: Constantino, Cláudia. "Deep learning-based fully automatic segmentation of whole-body [18F]FDG PET/CT images from lymphoma patients: addition of CT data has poor impact on networks performance". Paper presented in 36th Annual Congress of the European Association of Nuclear Medicine, Vienna, 2023. Published Cláudia S. Constantino; Sónia Leocádio; Francisco P. M. Oliveira; Mariana Silva; Carla Oliveira; Joana C. Castanheira; Ângelo Silva; et al. Corresponding author: Cláudia S. Constantino. "Quantifcation of whole-body [18F]FDG avid lymphoma lesions: advantages of semiautomatic over manual segmentation". Paper presented in Annual Congress of the European Association of Nuclear Medicine, 2021. Published Rui, Bergantim; Cristina João; Catarina Geraldes; Manuel Neves; Fernanda Trigo; Mariana Neves; João Mendes; Hugo Pedrosa; Paulo Lúcio. "Multiple Myeloma in Portugal: Incidênce, Prevalence, Mortality and Treatment Pathern". Paper presented in European Hematology Association Anual Meeting, Frankfurt, 2020. Published Manuel Neves; Fernanda Trigo; Rui Bergantim; Cristina João; Paulo Lúcio; Mariana Neves; João Mendes; et al. "Multiple Myeloma in Portugal: Burden of Disease and Cost if Illness". Paper presented in European Hematology Association Annual Meeting, Frankfurt, 2020. Published • 10.1007/s40273-020-00993-5
Conference paper	Cláudia S. Constantino; Oliveira, Francisco; Sónia Leocádio; Mariana Silva; Carla Oliveira; Joana C. Castanheira; Ângelo Silva; et al. "A robust deep-learning model for fully automatic segmentation of lymphoma lesions on whole-body [18F]FDG PET/CT images". Paper presented in IEEE International Symposium on Biomedical Imaging, 2024. Accepted Velosa Ferreira, Bruna; Ana Filipa Barahona Afonso; Pestana, Carolina; Ana Raquel lopes; Matthiesen, Rune; Caetano, Joana. "Extrecellular vesicle proteins as biomarker of outcome in multiple myeloma patients: a real world study". Paper presented in Perspectivas em Oncologia, Porto, 2022. Published Cristina João. "O tratamento com imunoglobulina ou fragmentos da molécula após transplante de precursores hematopoiéticos aumenta a proliferação celular à periferia". Paper presented in Annual Meeting of the Portuguese Society of Hematology 2008, torres vedras, 2008. Published Cristina João. "Treatment with polyclonal immunoglobulin and its fragments optimize recovery of IgM serum levels after autologous stem cells transplantation (ASCT)". Paper presented in Annual Meeting of Portuguese Society of Immunology 2007, lisboa, 2007. Cristina João. "Efeito da infusão de imunoglobulina ou seus derivados sobre a reconstituição imunológica após transplante autólogo de precursores hematopoiéticos (TAPH) num modelo animal (ratinho)". Paper presented in Annual Meeting Portuguese Society of Hematology 2007, Albufeira, 2007. Published João, Cristina; Matias T; Sá J.. "Paget’s Bone Disease associated with Myelofibrosis with Myeloid Metaplasiac". Paper presented in 6th National Congress of Internal Medicine, porto, 2000. Published João, Cristina; Silva, M.,; Nolasco I; Cabeçacas J; Parreira A. "Review of 6 cases of Kikushi-Fujimoto Disease from the Hematology Department of Francisco Gentil Portuguese Oncology Institute, Lisbon". Paper presented in Portuguese Hematology Society Annual Meeting 1999, Estoril, 1999. Published
Conference poster	Caetano, Joana; Cristina João. "Characterizing the circulating immune cell populations in asymptomatic and symptomatic myeloma patients using high-dimensional spectral flow cytometry.". Paper presented in Annual Meeting of the Portuguese Society of Hematology, Viseu, Portugal, 2023. Caetano, Joana; Cristina João. "Characterizing the immune cell populations in asymptomatic and symptomatic myeloma patients using high-dimensional spectral flow cytometry". Paper presented in 12th ESLHO Symposium, Salamanca, Spain, 2023. Caetano, Joana; Cristina João. "Immune cell populations present in peripheral blood of asymptomatic and symptomatic myeloma patients". Paper presented in NOVA Research Week, Lisbon, Portugal, 2023. Caetano, Joana; Cristina João. "MRDeep Study: Measurable Residual Disease rates in patients with Multiple Myeloma who achieved complete response in 2nd or 3rd lines of treatment in Portugal.". Paper presented in 20th Annual IMS Meeting, Athens, Greece, 2023. Barahona, Filipa; Klein Wolterink, Roel; Galzerano, Antonio; Arnault Carneiro, Emilie; Caetano, Joana; Ferreira, Bruna Velosa; Queirós, Ana C.; Cristina João. "Multiple Myeloma and adjacent NK cells express the machinery to integrate neuronal signals". Paper presented in EHA2023 Hybrid Congress, 2023. 10.1097/01.HS9.0000970252.77706.5e Caetano, Joana; Cristina João. "High-dimensional spectral cytometry characterization of the circulating immune cell profile of asymptomatic and symptomatic myeloma patients". Paper presented in EHA2023 Congress, Frankfurt, Germany, 2023. Caetano, Joana; Cristina João. "High-dimensional spectral cytometry characterization of the circulating immune cell profile of asymptomatic and symptomatic myeloma patients". Paper presented in 31th Sabatina de Hematología, Coimbra, Portugal, 2023. Lopes, Raquel; Diana Lourenço; Caetano, Joana; Ana Filipa Barahona Afonso; Velosa Ferreira, Bruna; QUEIRÓS, ANA; Arnault Carneiro, Emilie; Serre, Karine; Cristina João. "It takes two to tango: multiple myeloma and bone marrow immune cells". Paper presented in 16th ENII EFI EJI Summer School on Advanced Immunology, 2023. Cristina João; Caetano, Joana. "Measurable Residual Disease (MRD) assessment in the management of Multiple Myeloma (MM) in a real-world setting.". Paper presented in XVIII Congress of the Iberian Society of Cytometry, Madrid, Spain, 2023. Cristina João; Caetano, Joana. "Insights on how multiple myeloma-derived extracellular vesicles modulate the bone marrow niche". Paper presented in XLVIII Annual Meeting of the Portuguese Society of Immunology, Aveiro, Portugal, 2023. Ana Raquel lopes; Caetano, Joana; Ana Filipa Barahona; Velosa Ferreira, Bruna; Diana Lourenço; Ana C. Queirós; Matthiesen, Rune; et al. "Insights on how multiple myeloma-derived extracellular vesicles modulate the bone marrow immune niche". Paper presented in XLVIII Annual Meeting Portuguese Socienty of Immunology, 2023. Lopes, Raquel; Caetano, Joana; Ana Filipa Barahona Afonso; Velosa Ferreira, Bruna; Diana Lourenço; QUEIRÓS, ANA; Matthiesen, Rune; et al. "Insights on how multiple myeloma-derived extracellular vesicles modulate the bone marrow niche". Paper presented in XLVIII Annual Meeting Portuguese Society of Immunology, 2023. Francisco Silva; Lopes, Raquel; Ana Sofia Capacho; Maria Fortunato; Sofia Vaz; Oliveira, Francisco; Cristina João; Costa, Durval C.. ""In house" radiolabeling of anti-PD-L1 monoclonal antibodies with 111-Indium for in vivo imaging". Paper presented in EANM-23, 2023. Lopes, Raquel; Caetano, Joana; Ana Filipa Barahona Afonso; Pestana, Carolina; Velosa Ferreira, Bruna; Diana Lourenço; QUEIRÓS, ANA; et al. "Are you talking to me? How multiple myeloma-derived extracellular vesicles reprogramme the bone marrow immune niche". Paper presented in Champalimaud Research Symposium, 2022. Lopes, Raquel; Caetano, Joana; Ana Filipa Barahona Afonso; Pestana, Carolina; Velosa Ferreira, Bruna; Diana Lourenço; QUEIRÓS, ANA; et al. "Unraveling the crosstalk beterrn multiple myeloma and the bone marrow immune microenvironment: a role for myeloma-derived extracellular vesicles?". Paper presented in XV CAML V NeurULisboa PhD Students meeting, 2022. Lopes, Raquel; Caetano, Joana; Ana Filipa Barahona Afonso; Pestana, Carolina; Velosa Ferreira, Bruna; Diana Lourenço; QUEIRÓS, ANA; et al. "Multiple myeloma-derived extracellular vesicles induce an immunosuppressive bone marrow microenvironment". Paper presented in XLVII Annual Meeting Portuguese Society of Immunology, 2022. Nørgaard, Jakob Nordberg; Niels Abildgaard; Lysén, Anna; Tsykunova, Galina; Vangsted, Annette Juul; Cristina João; Remen, Nora; et al. "KRd Consolidation in Myeloma Patients with a Positive PET-CT after Standard First Line Treatment: A Phase II Study (CONPET)". Paper presented in The American Society of Hematology Annual Meeting & Exposition, Atlanta, USA, 2021. Pestana, Carolina; SOUSA, LISETE; Cristina João. Corresponding author: Cristina João. "Study of biomarkers in Multiple Myeloma: a statistical approach for longitudinal assessment of extracellular vesicles and its prognostic value". Paper presented in 5.ª Conferência Anual da redeSAÚDE, 2021. Cláudia S. Constantino; Sónia Leocádio; Francisco Oliveira; Mariana Silva ; Carla Oliveira; Joana Castanheira; Ângelo Silva; et al. "Quantification of whole-body [18F]FDG avid lymphoma lesions: advantages of semiautomatic over manual segmentation. DOI: 10.1007/s00259-021-05547-1". Paper presented in European Association of Nuclear Medicine, 2021. Giovanni Palladini; Stefan Schönland; Giampaolo Merlini; Paolo Milani; Arnaud Jaccard; Frank Bridoux; Meletios A. Dimopoulos; et al. "Real-World Data on Patient Characteristics and Treatment Patterns for 3000 Patients with Systemic AL Amyloidosis in Europe between 2011 and 2018: A Retrospective Study by the European Myeloma Network". Paper presented in European Hematology Association Annual Meeting, 2021. Lopes, Raquel; Joana Filipa Braga de Jesus Caetano; Ana Filipa Barahona Afonso; Bruna Velosa Ferreira; Carolina Pestana; Emilie Carneiro; Cristina João; et al. "Immunosuppressive bone marrow microenvironment induced by multiple myeloma-derived extracellular vesicles". Paper presented in 2nd European Myeloma Network Meeting, 2021. Ana Martins-Logrado; Filipa Barahona; Vanda Póvoa; Cátia Almeida; Joana Caetano; Sónia Leocádio; Manuel Neves; et al. "Zebrafish "avatars" as a tool for personalized treatment of CLL patients.". Paper presented in Translational Research Conference on Chronic Lymphocytic Leukaemia Online, 2020. Carolina Pestna; SOUSA, LISETE; Emilie Carneiro; Ana Filipa Barahona; Joana Caetano; Ana Raquel lopes; Bruna Ferreira; Cristina João. "Statistical methods for the study of extracellular vesicles content and their potential as biomarkers of multiple myeloma aggressivenesshttps://proa.ua.pt/index.php/jshd/article/view/19953/15330". Paper presented in 2nd Statistics on Health Decision Making (SHDM): clinical trials, 2020. Raquel Lopes; Joana Caetano; Filipa Barahona; Bruna Velosa Ferreira; Jácome Toste; Catarina Ventura; Emilie Arnault Carneiro; Bruno Costa-Silva; Cristina João. "Immunosupressive Bone Marrow microenvironment via extracellular vesicles in multiple myeloma". Paper presented in Cancer Biology - From Basic to Translational Research, 2020. Lopes, Raquel; Joana Filipa Braga de Jesus Caetano; Ana Filipa Barahona Afonso; Bruna Velosa Ferreira; Emilie Carneiro; Jácome Toste; Catarina Ventura; et al. "Immunossupressive BM microenvironment via extracellular vesicles in Multiple Myeloma". Paper presented in Cancer Biology: From Basic to Translational Research, 2020. G. Palladini; G. Merlini; P. Milani; R. Hajek; R. Bergantim; Cristina João; S. Scho¨nland; et al. "Real World Management of Patients with Systemic Light Chain Amyloidosis in Europe: A Retrospective Observational Multicenter Study by European Myeloma Network". Paper presented in European Hematology Association Annual Meeting, 2020. Emilie Carneiro; Bruna Ferreira; Ana Filipa Barahona; joana Caetano; Raquel Lopes; Jácome Toste; Catarina Ventura; et al. "Extracellular vesicles proteins and their potential as biomarkers of multiple myeloma aggressiveness". Paper presented in Annual Meeting of Sociedade Portuguesa de Hematologia, Braga, Portugal, 2019. Ana Logrado; Vanda Póvoa; joana Caetano; Ana Filipa Barahona; Raquel Lopes; Sónia Leocádio; Manuel Neves; et al. "Zebrafish Avatars as a tool for personalized treatment of CLL patients - establishing a model". Paper presented in Annual Meeting of Sociedade Portuguesa de Hematologia, Braga, Portugal, 2019. Raquel Lopes; Bruna Ferreira; joana Caetano; Ana Filipa Barahona; Emilie Carneiro; Jácome Toste; Catarina Ventura; et al. "Exploring the bone marrow microenvironment communication via extracellular vesicles in multiple myeloma". Paper presented in Champalimaud Research Symposium 2019: Tissue Environment in Health and Disease, Lisbon, Portugal, 2019. 10.1158/1538-7445.am2014-972 Bruna Ferreira; Emilie Carneiro; Ana Filipa Barahona; Paulo Lúcio; Manuel Neves; Bruno Costa-Silva; Cristina João. "Exosomal Cargo in monoclonal gammopathies compared to healthy donors and its potential relation to myeloma aggressiveness". Paper presented in The 24th European Hematology Association Congress, Amesterdam, Netherlands, 2019. Bruna Ferreira; Paulo Lúcio; Manuel Neves; António Parreira; Bruno Costa-Silva; Cristina João. "Characterization of Circulating and Bone Marrow Derived Exosomes in Multiple Myeloma Patients". Paper presented in The American Society of Hematology Annual Meeting, San Diego, USA, 2018. Cristina João. "Absolute lymphocyte count and CD4 count predict a superior progression-free survival in non-Hodgkin’s lymphoma patients treated with rituximab and Interleukin-12". Paper presented in American Society of Hematology meeting, Atlanta, USA., 2015. João, Cristina; Carlos Costa (5913-6819-3D1E); Fernanda Trigo; Sergio Chacim; Paulo Lucio; Cristina Gonçalves; Ana Macedo. "ChatGPT Experience with the use of the MPT regimen in the treatment of patients with MM - Study by the Portuguese Multiple Myeloma Group". Paper presented in Annual Meeting of the Portuguese Society of Hematology, 2012. Sara Gomes; Carlos Costa (5913-6819-3D1E); João, Cristina; António Medina Almeida; Susana Carvalho; António Parreira. "Cryoglobulinemias, a common presence in various pathologies". Paper presented in Reunião Anual da Sociedade Portuguesa de Hematologia, Tróia, Portugal, 2010. Sara Gomes; Carlos Costa (5913-6819-3D1E); João, Cristina; António Medina Almeida; Susana Carvalho; António Parreira. "Basiodioboliomicose: diagnóstico diferencial de adenopatias: a propósito de um caso clínico". Paper presented in Reunião Anual da Sociedade Portuguesa de Hematologia, Tróia, Portugal, 2010. Lígia Justo; Barahona Afonso, Ana; Ana Queirós; Constantin Fesel; Ana Elisabete Pires; João, Cristina. "Immunoglobulin Treatment Improves Reconstitution of B Cell Compartment After Autologous Stem Cell Transplantation (ASCT)". Paper presented in Annual Meeting of the European Society of Hematology, Barcelona, Spain, 2010. Ana Filipa Barahona; Pires, Ana Elisabete; joana Caetano; Fátima Francisco; Maria Gomes da Silva; Cristina João. "Alterações imunológcas em doentes com Linfoma Não Hodgkin B (LNH B) induzidas pelo tratamento com poliquimioterapua e Rituximab". Paper presented in Annual Meeting of Sociedade Portuguesa de Hematologia, Tróia, Portugal, 2009. Ana Elisabete Pires; Salomé Cabral; Susana Esteves; Maria Gomes da Silva; Luís Porrata; Svetomir N. Markovic; Cristina João. "The effect of infusion of polyclonal immunoglobulin or its fragments in the improvement of the immune reconstitution after autologous stem cells transplantation (ASCT) in a murine model". Paper presented in American Society of Hematology Meeting, Atlanta, USA, 2007. Cristina João; Susan Geyer; Markovic, Svetomir; Morie Gertz, Martha Lacy; Angela Dispenzieri; Shagi Kumar; Suzanne Hayman; Luis F. Porrata. "Recovery of polyclonal immunoglobulin serum levels to normal levels after autologous stem cell transplantation predicts disease free survival in patients with multiple myeloma". Paper presented in American Society of Clinical Oncology meeting, Atlanta, USA., 2006. Cristina João; Luis F. Porrata; Ed Burgstaler; Wendy Neval; Cindy Uhl; Rajini Katipamula; Dennis A. Gastineau; Jeffrey Winters; Svetomir N. Markovic. "Immunologic autograft engineering by manipulation of apheresis machine collection settings". Paper presented in CIBMTR meeting, Hawaii, USA, 2006. Cristina João. "Early Lymphocyte Recovery after Autologous Stem Cell Transplantation Predicts Superior Survival in Mantle Cell Lymphoma". Paper presented in American Society of Hematology meeting, Atlanta, USA, 2005. Cristina João. "Recuperação Precoce do número total de linfocitos após transplante autólogo de precursores hematopoieticos prediz uma sobrevida superior em doentes com Linfoma do Manto". Paper presented in Annual Meeting of Sociedade Portuguesa de Hematologia, Espinho, Portugal, 2005. Cristina João. "TCR diversity and immune responses to transplants". Paper presented in Annual Meeting of Sociedade Portuguesa de Imunologia, Lisbon, Portugal, 2004. Cristina João. "TCR Diversity and the mounting of alloimmune response". Paper presented in American Transplantation Congress, Boston, USA., 2004. Cristina João. "Alterações citogenéticas numéricas em Linfomas MALT". Paper presented in Annual Meeting of Sociedade Portuguesa de Hematologia, Buçaco, Portugal, 2003. Cristina João. "B cell directed alloimmunity: a question revisited". Paper presented in American Transplantation Congress, Washington, USA., 2003. Cristina João. "Compatibility tests in patients with Warm-antibodies Autoimmune Hemolytic Anemia". Paper presented in I Simposium of Immunohematology, Porto, Portugal, 2001. Cristina João. "Primary Mediastinal Sclerosant Non-Hodgkin B Lymphoma: review of 7 cases from the Hematology Department of Francisco Gentil’s Portuguese Oncology Institute, Lisbon". Paper presented in 6th National Congress of Internal Medicine, Porto, Portugal, 2000.
Journal article	Jaccard, Arnaud; Bridoux, Frank; Roeloffzen, Wilfried; Minnema, Monique C.; Bergantim, Rui; Hájek, Roman; João, Cristina; et al. "Healthcare resource utilization and cost-of-illness in systemic light chain (AL) amyloidosis in Europe: results from the real-world, retrospective EMN23 study". Clinical Lymphoma Myeloma and Leukemia (2024): http://dx.doi.org/10.1016/j.clml.2024.01.013. Open access • In press • 10.1016/j.clml.2024.01.013 Costa, Carlos BT; Neves, Manuel; Roque, Adriana Isabel; Sarmento-Ribeiro, Ana Bela; Gerivaz, Rita; Tomé, Ana; Afonso, Sofia; et al. "Assessment of Multiple Myeloma-Related Burden on Caregivers - a Portuguese National Study". Blood 142 Supplement (2023): 3335-3335. http://dx.doi.org/10.1182/blood-2023-182698. 10.1182/blood-2023-182698 Nørgaard, Jakob Nordberg; Abildgaard, Niels; Lysén, Anna; Tsykunova, Galina; Vangsted, Annette Juul; João, Cristina; Remen, Nora; et al. "Intensifying treatment in PET-positive multiple myeloma patients after upfront autologous stem cell transplantation". Leukemia 37 10 (2023): 2107-2114. http://dx.doi.org/10.1038/s41375-023-01998-7. 10.1038/s41375-023-01998-7 Filipa Barahona, Ana; Klein Wolterink, Roel; Galzerano, Antonio; Carneiro, Emilie; Caetano, Joana; Velosa Ferreira, Bruna; Queirós, Ana; João, Cristina. "P837: High-dimensional spectral cytometry characterization of the circulating immune cell profile in asymptomatic and symptomatic myeloma patients". HemaSphere 7 S3 (2023): e777065e. http://dx.doi.org/10.1097/01.hs9.0000970252.77706.5e. Published • 10.1097/01.hs9.0000970252.77706.5e Caetano, Joana; Barahona, Filipa; Neves, Manuel; Velosa Ferreira, Bruna; Leocádio, Sónia; Queirós, Ana; Lúcio, Paulo; João, Cristina. "P821: High-dimensional spectral cytometry characterization of the circulating immune cell profile in asymptomatic and symptomatic myeloma patients". HemaSphere 7 S3 (2023): e54601b9. http://dx.doi.org/10.1097/01.hs9.0000970188.54601.b9. Published • 10.1097/01.hs9.0000970188.54601.b9 João, Cristina; Bergantim, Rui; Santos, Joana; Afonso, Celina; Bernardo, Paulo; Coelho, Henrique; Costa, Carlos; et al. "Recommendations from the Portuguese Multiple Myeloma Group for the Treatment of Multiple Myeloma". Acta Médica Portuguesa 36 7-8 (2023): 517-526. http://dx.doi.org/10.20344/amp.19037. 10.20344/amp.19037 João, Cristina; Bergantim, Rui; Santos, Joana; Afonso, Celina; Bernardo, Paulo; Coelho, Henrique; Costa, Carlos; et al. "Recomendações do Grupo Português do Mieloma Múltiplo para Tratamento do Mieloma Múltiplo". Acta Médica Portuguesa 36 7-8 (2023): 517-526. http://dx.doi.org/10.20344/amp.19037. 10.20344/amp.19037 Constantino, Cláudia S.; Leocádio, Sónia; Oliveira, Francisco P. M.; Silva, Mariana; Oliveira, Carla; Castanheira, Joana C.; Silva, Ângelo; et al. "Evaluation of Semiautomatic and Deep Learning–Based Fully Automatic Segmentation Methods on [18F]FDG PET/CT Images from Patients with Lymphoma: Influence on Tumor Characterization". Journal of Digital Imaging 36 4 (2023): 1864-1876. http://dx.doi.org/10.1007/s10278-023-00823-y. 10.1007/s10278-023-00823-y Cristina João. "World Health Day - Multiple Myeloma". Revista Business Portugal (2023): https://issuu.com/revistabusinessportugal/docs/rbp_marco_2023-online. Cristina João. "Everything you need to know about Multiple Myeloma". Sapo Lifestyle - Saúde e Medicina (2023): https://lifestyle.sapo.pt/saude/saude-e-medicina/artigos/tudo-o-que-precisa-de-saber-sobre-o-mieloma-multiplo. Palladini, Giovanni; Schönland, Stefan; Merlini, Giampaolo; Milani, Paolo; Jaccard, Arnaud; Bridoux, Frank; Dimopoulos, Meletios A.; et al. "The management of light chain (AL) amyloidosis in Europe: clinical characteristics, treatment patterns, and efficacy outcomes between 2004 and 2018". Blood Cancer Journal 13 1 (2023): http://dx.doi.org/10.1038/s41408-023-00789-8. 10.1038/s41408-023-00789-8 Helena Sousa; Lara Cunha; Isabel Barbosa; Sergio Chacim; Ana Francisco; Joana Tato; Cristina João. Corresponding author: Cristina João. "Living with multiple myeloma: Impact of the disease on patients' life in Portugal". Healthcare (2023): Submitted Fernanda Braga Seganfredo; Ana Raquel Dias; Pedro R. Santos; Marta Rebelo; Cristina João; Dina Mendes; Eduarda Carmo. "Successful treatment of persistent and severe SARS-CoV-2 infection in a high-risk chronic lymphocytic leukemia patient using Ronapreve™ antibodies". Clinical Case Reports (2022): https://doi.org/10.1002/ccr3.6548. 10.1002/ccr3.6548 Diana Lourenço; Raquel Lopes; Carolina Pestana; Ana C. Queirós; Cristina João; Emilie Arnault Carneiro. "Patient-Derived Multiple Myeloma 3D Models for Personalized Medicine—Are We There Yet?". International Journal of Molecular Sciences (2022): https://doi.org/10.3390/ijms232112888. 10.3390/ijms232112888 Lopes, Raquel; Caetano, Joana; Barahona, Filipa; Pestana, Carolina; Ferreira, Bruna Velosa; Lourenço, Diana; Queirós, Ana C.; et al. "Multiple Myeloma-Derived Extracellular Vesicles Modulate the Bone Marrow Immune Microenvironment". Frontiers in Immunology 13 (2022): http://dx.doi.org/10.3389/fimmu.2022.909880. Published • 10.3389/fimmu.2022.909880 Joana Caetano; Filipa Barahona; Paulo Lúcio; Cristina João. "Measurable Residual Disease Assessment in Multiple Myeloma: How Deep Is Enough?". Hemato 3 3 (2022): 385-413. https://doi.org/10.3390/hemato3030027. 10.3390/hemato3030027 Ferreira, Bruna Velosa; Carneiro, Emilie Arnault; Pestana, Carolina; Barahona, Filipa; Caetano, Joana; Lopes, Raquel; Lúcio, Paulo; et al. "Patient-Derived Extracellular Vesicles Proteins as New Biomarkers in Multiple Myeloma - A Real-World Study". Frontiers in Oncology 12 (2022): http://dx.doi.org/10.3389/fonc.2022.860849. Open access • Published • 10.3389/fonc.2022.860849 Ferreira, Bruna; Emilie Carneiro; Pestana, Carolina; Barahona, AF; Joana filipa caetano; Lucio, Paulo; Neves, Manuel; et al. "Extracellular vesicles protein cargo as new prognostic biomarker for Multiple Myeloma - a real-life observational study". Frontiers in oncology (2022): Submitted Emilie Arnault Carneiro; Filipa Barahona; Carolina Pestana; Cristina João. "Is Circulating DNA and Tumor Cells in Myeloma the Way Forward?". Hemato (2022): https://doi.org/10.3390/hemato3010006. 10.3390/hemato3010006 Bárbara B. Sousa; Rebelo de Almeida, Cátia; Ana Filipa Barahona Afonso; Lopes, Raquel; Ana Martins-Logrado; Cavaco, Marco; Neves, Vera; et al. "Selective inhibition of Brutons tyrosineyrosine kinase by a designed covalent ligand leads to potent therapeutic efficacy in blood cancers relative to clinically used inhibitors.". ACS Pharmacology and Translational Science (2022): 1-13. https://doi.org/10.1021/acsptsci.2c00163. Published • 10.1021/acsptsci.2c00163 Lopes, Raquel; Caetano, Joana; Ana Filipa Barahona Afonso; Pestana, Carolina; Bruna Velosa Ferreira; Diana Lourenço; QUEIRÓS, ANA; et al. "Multiple myeloma-derived extracelular vesicles modulate the bone marrow immune microenvironment.". Frontiers in Immunology (2022): https://doi.org/10.3389/fimmu.2022.909880. Published Velosa Ferreira, Bruna; Arnault Carneiro, Emilie; Pestana, Carolina; Ana Filipa Barahona Afonso; Caetano, Joana; Lopes, Raquel; Lucio, Paulo; et al. "Patient-derived extracelullar vesicles proteins as new biomarkers in multiple myeloma: a real-world study". Frontiers in Oncology (2022): https://doi.org/10.3389/fonc.2022.860849.. Published Lopes, Raquel; Ferreira, Bruna Velosa; Caetano, Joana; Barahona, Filipa; Carneiro, Emilie Arnault; João, Cristina. "Boosting Immunity against Multiple Myeloma". Cancers 13 6 (2021): 1221. http://dx.doi.org/10.3390/cancers13061221. Open access • Published • 10.3390/cancers13061221 Moreau, Philippe; Kumar, Shaji K; San Miguel, Jesús; Davies, Faith; Zamagni, Elena; Bahlis, Nizar; Ludwig, Heinz; et al. "Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group". The Lancet Oncology 22 3 (2021): e105-e118. http://dx.doi.org/10.1016/s1470-2045(20)30756-7. Open access • Published • 10.1016/s1470-2045(20)30756-7 Lopes, Raquel; Caetano, Joana; Ferreira, Bruna; Barahona, Filipa; Carneiro, Emilie Arnault; João, Cristina. "The Immune Microenvironment in Multiple Myeloma: Friend or Foe?". Cancers 13 4 (2021): 625. http://dx.doi.org/10.3390/cancers13040625. 10.3390/cancers13040625 Pestana, Carolina; SOUSA, LISETE; Arnault Carneiro, Emilie; Barahona, AF; Caetano, Joana; Lopes, Raquel (A71E-87C5-1CC5; Velosa Ferreira, Bruna; Cristina João. "Statistical methods for the study of extracellular vesicles content and their potential as biomarkers of multiple myeloma aggressiveness". Journal of Statistics on Health Decision 2 2 (2020): https://doi.org/10.34624/jshd.v2i2.19953. Published • 10.34624/jshd.v2i2.19953 João, Cristina; Geraldes, Catarina; Neves, Manuel; Mariz, Mário; Trigo, Fernanda. "Management of older and frail patients with multiple Myeloma in the Portuguese routine clinical practice: Deliberations and recommendations from an expert panel of hematologists". Journal of Geriatric Oncology (2020): http://dx.doi.org/10.1016/j.jgo.2020.06.002. 10.1016/j.jgo.2020.06.002 Ferreira, Bruna; Caetano, Joana; Barahona, Filipa; Lopes, Raquel; Carneiro, Emilie; Costa-Silva, Bruno; João, Cristina. "Liquid biopsies for multiple myeloma in a time of precision medicine". Journal of Molecular Medicine (2020): http://dx.doi.org/10.1007/s00109-020-01897-9. 10.1007/s00109-020-01897-9 Almeida, Sílvia D.; Santinha, João; Oliveira, Francisco P. M.; Ip, Joana; Lisitskaya, Maria; Lourenço, João; Uysal, Aycan; et al. "Quantification of tumor burden in multiple myeloma by atlas-based semi-automatic segmentation of WB-DWI". Cancer Imaging 20 1 (2020): http://dx.doi.org/10.1186/s40644-020-0286-5. Published • 10.1186/s40644-020-0286-5 Cristina João; Rui Bergantim; Manuel Neves; Sérgio Chacim; Celina Afonso; João Barradas; Manuela Bernardo; et al. "Multiple myeloma in elderly patients—a Portuguese multicentric real-life study". Annals of Hematology 98 7 (2019): 1689-1701. https://doi.org/10.1007/s00277-019-03640-y. 10.1007/s00277-019-03640-y Richardson, P.G.; Oriol, A.; Beksac, M.; Liberati, A.M.; Galli, M.; Schjesvold, F.; Lindsay, J.; et al. "Pomalidomide, bortezomib, and dexamethasone for patients with relapsed or refractory multiple myeloma previously treated with lenalidomide (OPTIMISMM): a randomised, open-label, phase 3 trial". The Lancet Oncology 20 6 (2019): 781-794. http://www.scopus.com/inward/record.url?eid=2-s2.0-85067190733&partnerID=MN8TOARS. 10.1016/S1470-2045(19)30152-4 Hillengass, J.; Usmani, S.; Rajkumar, S.V.; Durie, B.G.M.; Mateos, M.-V.; Lonial, S.; Joao, C.; et al. "International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders". The Lancet Oncology 20 6 (2019): e302-e312. http://www.scopus.com/inward/record.url?eid=2-s2.0-85066247461&partnerID=MN8TOARS. 10.1016/S1470-2045(19)30309-2 Rb-Silva, R.; Goios, A.; Kelly, C.; Teixeira, P.; João, C.; Horta, A.; Correia-Neves, M.. "Definition of Immunological Nonresponse to Antiretroviral Therapy: A Systematic Review". Journal of Acquired Immune Deficiency Syndromes 82 5 (2019): 452-461. http://www.scopus.com/inward/record.url?eid=2-s2.0-85074875241&partnerID=MN8TOARS. 10.1097/QAI.0000000000002157 Cristina João; Vir Singh Negi; Michel D. Kazatchkine; Jagadeesh Bayry; Srini V. Kaveri. "Passive Serum Therapy to Immunomodulation by IVIG: A Fascinating Journey of Antibodies". The Journal of Immunology 200 6 (2018): 1957-1963. https://doi.org/10.4049/jimmunol.1701271. 10.4049/jimmunol.1701271 Rule S; Jurczak W; Jerkeman M; Rusconi C; Trneny M; Offner F; Caballero D; et al. "Ibrutinib versus temsirolimus: 3-year follow-up of patients with previously treated mantle cell lymphoma from the phase 3, international, randomized, open-label RAY study.". Leukemia (2018): http://europepmc.org/abstract/med/29572505. 10.1038/s41375-018-0023-2 Georg Hess; Simon Rule; Wojciech Jurczak; Mats Jerkeman; Rodrigo Santucci Silva; Chiara Rusconi; Dolores Caballero; et al. "Health-related quality of life data from a phase 3, international, randomized, open-label, multicenter study in patients with previously treated mantle cell lymphoma treated with ibrutinib versus temsirolimus". Leukemia & Lymphoma 58 12 (2017): 2824-2832. https://doi.org/10.1080%2F10428194.2017.1326034. 10.1080/10428194.2017.1326034 Moreau P; Dimopoulos MA; Richardson PG; Siegel DS; Cavo M; Corradini P; Weisel K; et al. "Adverse event management in patients with relapsed and refractory multiple myeloma taking pomalidomide plus low-dose dexamethasone: A pooled analysis.". European journal of haematology (2017): http://europepmc.org/abstract/med/28504846. 10.1111/ejh.12903 João C; Freitas J; Gomes F; Geraldes C; Coelho I; Neves M; Lúcio P; et al. "Lenalidomide is effective and safe for the treatment of patients with relapsed multiple myeloma and very severe renal impairment.". Annals of Hematology 95 6 (2016): 931-936. http://europepmc.org/abstract/med/27068406. Published • 10.1007/s00277-016-2662-6 Barahona Afonso AF; João CM. "The Production Processes and Biological Effects of Intravenous Immunoglobulin.". (2016): http://europepmc.org/abstract/med/27005671. 10.3390/biom6010015 Dreyling M; Jurczak W; Jerkeman M; Silva RS; Rusconi C; Trneny M; Offner F; et al. "Ibrutinib versus temsirolimus in patients with relapsed or refractory mantle-cell lymphoma: an international, randomised, open-label, phase 3 study.". (2016): http://europepmc.org/abstract/med/26673811. 10.1016/S0140-6736(15)00667-4 João C; Coelho I; Costa C; Esteves S; Lucio P. "Efficacy and safety of lenalidomide in relapse/refractory multiple myeloma--real life experience of a tertiary cancer center.". (2015): http://europepmc.org/abstract/med/25038919. 10.1007/s00277-014-2164-3 Carlos Costa; Cristina João; Inês Coelho; Maria João Vergueiro; Mafalda Ferreira; Maria Gomes da Silva; João C; et al. "Long-term Survival in Multiple Myeloma". Clinical Case Reports 2 5 (2014): 1-7. http://dx.doi.org/10.1001/archinte.1986.00360200217047. Published • 10.1002/ccr3.76 Parreira J; Lúcio P; João C; Macedo A; Sarmento AB; Geraldes C; Gonçalves C; Esteves G. "Monoclonal gammopathies of indetermined significance: diagnosis and clinical follow-up guidelines". (2014): http://europepmc.org/abstract/med/25409226. Parreira, J.; Lúcio, P.; João, C.; Macedo, A.; Sarmento, A.B.; Geraldes, C.; Gonçalves, C.; Esteves, G.. "Monoclonal gammopathies of indetermined significance: Diagnosis and clinical follow-up guidelines,Gamapatias monoclonais de significado indeterminado: Critérios de diagnóstico e acompanhamento clínico". Acta Medica Portuguesa 27 5 (2014): 661-664. http://www.scopus.com/inward/record.url?eid=2-s2.0-84908397086&partnerID=MN8TOARS. 10.20344/amp.5411 Costa, N.; Pires, A.E.; Gabriel, A.M.; Goulart, L.F.; Pereira, C.; Leal, B.; Queiros, A.C.; et al. "Broadened T-cell repertoire diversity in ivIg-treated SLE patients is also related to the individual status of regulatory T-cells". Journal of Clinical Immunology 33 2 (2013): 349-360. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879881255&partnerID=MN8TOARS. 10.1007/s10875-012-9816-7 Afonso, A.B.; Justo, L.N.; Queirós, A.C.; Fesel, C.; Cabral, M.S.; Da Silva, M.G.; Porrata, L.; et al. "Treatment with low doses of polyclonal immunoglobulin improves B cell function during immune reconstitution in a murine model". Journal of Clinical Immunology 33 2 (2013): 407-419. http://www.scopus.com/inward/record.url?eid=2-s2.0-84879888117&partnerID=MN8TOARS. 10.1007/s10875-012-9802-0 João, C.; Figueiredo, A.; Martins, H.F.. "Advantageous use of lenalidomide in multiple myeloma: Discussion of three case studies". Current Opinion in Oncology 24 SUPPL. 2 (2012): http://www.scopus.com/inward/record.url?eid=2-s2.0-84855934316&partnerID=MN8TOARS. 10.1097/01.cco.0000410244.91697.5a Costa N; Pires AE; Gabriel AM; Goulart LF; Pereira C; Leal B; Queiros AC; et al. "Active regulatory T-cells contribute to broadened T-cell repertoire diversity in ivIg-treated SLE patients.". Journal of translational medicine (2011): http://europepmc.org/abstract/PMC/PMC3242290. 10.1186/1479-5876-9-S2-P6 Pires, A.E.; Afonso, A.F.; Queirós, A.; Cabral, M.S.; Porrata, L.; Markovic, S.N.; Kaveri, S.V.; Da Silva, M.G.; João, C.. "Treatment with polyclonal immunoglobulin during T-cell reconstitution promotes naive T-cell proliferation". Journal of Immunotherapy 33 6 (2010): 618-625. http://www.scopus.com/inward/record.url?eid=2-s2.0-77954956699&partnerID=MN8TOARS. 10.1097/CJI.0b013e3181d3cb19 João, C.; Farinha, P.; Da Silva, M.G.; Martins, C.; Crespo, M.; Cabeçadas, J.. "Cytogenetic abnormalities in MALT lymphomas and their precursor lesions from different organs. A fluorescence in situ hybridization (FISH) study". Histopathology 50 2 (2007): 217-224. http://www.scopus.com/inward/record.url?eid=2-s2.0-33846026333&partnerID=MN8TOARS. 10.1111/j.1365-2559.2007.02580.x Cristina João. "Immunoglobulin is a highly diverse self-molecule that improves cellular diversity and function during immune reconstitution". Medical Hypotheses 68 1 (2007): 158-161. http://www.scopus.com/inward/record.url?eid=2-s2.0-33750738300&partnerID=MN8TOARS. 10.1016/j.mehy.2006.05.062 Joao, C.; Porrata, L.F.; Inwards, D.J.; Ansell, S.M.; Micallef, I.N.; Johnston, P.B.; Gastineau, D.A.; Markovic, S.N.. "Early lymphocyte recovery after autologous stem cell transplantation predicts superior survival in mantle-cell lymphoma". Bone Marrow Transplantation 37 9 (2006): 865-871. http://www.scopus.com/inward/record.url?eid=2-s2.0-33646053849&partnerID=MN8TOARS. 10.1038/sj.bmt.1705342 João, C.; Ogle, B.M.; Geyer, S.. "Immunoglobulin promotes the diversity and the function of T cells". European Journal of Immunology 36 7 (2006): 1718-1728. http://www.scopus.com/inward/record.url?eid=2-s2.0-33746238425&partnerID=MN8TOARS. 10.1002/eji.200635908 João C; Ogle BM; Gay-Rabinstein C; Platt JL; Cascalho M. "B cell-dependent TCR diversification.". (2004): http://europepmc.org/abstract/med/15067046. 10.4049/jimmunol.172.8.4709 Ogle BM; Cascalho M; Joao C; Taylor W; West LJ; Platt JL; Ogle, B.M.; et al. "Direct measurement of lymphocyte receptor diversity.". Nucleic acids research 31 22 (2003): http://europepmc.org/abstract/med/14602932. 10.1093/nar/gng139 Cristina João; Malhadais N; Leite A.; Serra I.; Reves L.; Brandão, Tiago; Freitas, Paulo. "A case of Wegener‘s Granulomatosis". Revista Portuguesa Medicina Interna 3 (2001): 150-153. Published • 10.1002/art.11075 João, Cristina. "Von Willebrand Disease". Revista Portuguesa Medicina Interna 1 (2001): 28-36. Published João, C.; Matias, T.; João C; Matias T; João, Cristina; Teresa Matias; João Sá,. "Paget's disease associated with myelofibrosis and myeloid metaplasia--a common pathophysiology ?". Haematologica 86 8 (2001): E22. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035432117&partnerID=MN8TOARS. Published
Newspaper article	Cristina João. "Notes on Multiple Myeloma, a type of blood cancer", Raio-X , 2022, https://raiox.pt/notas-sobre-mieloma-multiplo-um-tipo-de-cancro-do-sangue/.

Other

Other output

"VOLTA" Project. A programme to train clinical teams at Vilanculo Regional Hospital in Mozambique with the means, equipment and training for point-of-care ultrasound diagnosis in various clinical contexts, such as trauma or infection.. 2023. Cristina João; Carlos Costa. https://www.gofundme.com/f/projeto-volta.

Activities

Oral presentation

	Presentation title	Event name Host (Event location)
2023/05/13	Multiple Myeloma and adjacent NK cells can express the machinery to integrate neuronal signals	31st Sabbath in Hematology Centro Hospitalar da Universidade de Coimbra (Coimbra, Portugal)
2021/12/11	Systemic light chain amyloidosis across Europe: Key outcomes from a retrospective study of 4500 patients	The American Society of Hematology Annual Meeting & Exposition, Atlanta, USA American Society of Hematology (Atlanta, United States)
2020/10/12	First glimpse on real-world efficacy outcomes for 2000 patients with systemic light chain amyloidosis in Europe: a retrospective observational multicenter study by the european myeloma network.	American Society of Hematology meeting (United States)
2020/02/12	Statistical methods for the study of extracellular vesicles content and their potencial as biomarkers of multiple myeloma aggressiveness	iMed Conference Universidade Nova de Lisboa Faculdade de Ciências Médicas (Lisboa, Portugal)
2016/11	Treatment of Multiple Myeloma old patients - a Portuguese multicentric real-life study	Annual Meeting of the Portuguese Society of Hematology Portuguese Society of Hematology (Povoa do Varzim, Portugal)
2014	New therapies in Hemato-oncology Immunotherapy and intra cellular signaling inhibition	Annual Meeting of the Portuguese Society of Human Genetics Portuguese Society of Human Genetics
2012/11/10	Lenalidomide in the treatment of relapsed/refractory Multiple Myeloma - Importance of early treatment on overall survival	Annual meeting of Sociedade Portuguesa de Hematologia Sociedade Portuguesa de Hematologia (Porto, Portugal)
2012/10/10	Respiratory amyloidosis, from surprise to panic	XXVIII Pulmonology Congress Sociedade Portuguesa de Pneumologia (Tróia, Portugal)
2012/01/26	Monoclonal gammopathies - From biology to treatment	Atualizações em Oncologia 2012, 26ª Reunião - 1º Congresso do Cimago Linha de Investigação Clínica e Interdisciplinar em Meio Ambiente, Genética e Oncobiologia (Coimbra, Portugal)
2011/11/11	Treatment with low-dose polyclonal immunoglobulin improves B lymphocyte cell function during immune reconstitution.	Anual Meeting of Sociedade Portuguesa de Hematologia Sociedade Portuguesa de Hematologia (Albufeira, Portugal)
2010/11/12	MPT as first-line treatment in multiple myeloma patients not eligible for transplant: a Portuguese multicenter study	Anual meeting of Sociedade Portuguesa de Hematologia Sociedade Portuguesa de Hematologia (Tróia, Portugal)
2009	A decade of thalidomide use in multiple myeloma patients - Experience from the Hematology Department of IPOFG, Lisbon	Jornadas do ROR Sul Registo Oncológico Regional (Lisboa, Portugal)
2009	Immunological interdependencies between B and T lymphocytes	“Manuela Correia lecture”, Annual Meeting of Sociedade Portuguesa de Hematologia Sociedade Portuguesa de Hematologia (Tróia, Portugal)
2008/11/14	Treatment with immunoglobulin or molecule fragments after hematopoietic precursor transplantation increases peripheral cell proliferation	Anual Meeting of Sociedade Portuguesa de Hematologia Sociedade Portuguesa de Hematologia (Torres Vedras, Portugal)
2007/11/10	Effect of immunoglobulin or its derivatives infusion on immune reconstitution after autologous hematopoietic stem cell transplantation (ASCT) in an animal model (mouse)	Anual Meeting of Sociedade Portuguesa de Hematologia Sociedade Portuguesa de Hematologia (Albufeira, Portugal)
2007	Treatment with polyclonal immunoglobulin and its fragments optimize recovery of IgM serum levels after autologous stem cells transplantation (ASCT)	Reunião Anual da Sociedade Portuguesa de Imunologia Sociedade Portuguesa de Imunologia (Lisboa, Portugal)
2007	Immune reconstitution after autologous stem cell transplantation	Scientific meeting Unidade de Investigação em Patobiologia Molecular, Francisco Gentil’s - Portuguese Oncology Institute (Lisboa, Portugal)
2005/04	Immunoglobulin Heavy Chain and the life of Memory B cells - Abstract 47.2	FASEB Research Conference - American Society of Immunology Meeting Federation of American Societies for Experimental Biology (san Diego, United States)
2005	Survival of B Cells Lacking Surface Ig	Keystone B cells Meeting (Colorado, United States)
2004/12	Driving T cell development in the thymus, abstract # 3860	American Society of Hematology meeting, 2004, San Diego, USA. American Society of Hematology (San Diego, United States)
2004/11	Impact of B lymphocytes on T lymphocyte development	Annual Meeting of Sociedade Portuguesa de Hematologia Sociedade Portuguesa de Hematologia (Portugal)
2004/06	A new road to T cell diversification	9th Congress of the European Hematology Association European Hematology Association (Genebra, Switzerland)
2004/05	T cell repertoire expansion by B cells and immunoglobulin	American Transplantation Congress Annual Meeting American Transplantation Congress (Boston, United States)
2004/04	B cells directed-T cell development	American Society of Immunology Meeting, FASEB 2004 FASEB (Washington, D.C., United States)
2004	Heavy chain promotes positive selection of CD4 T cells	Annual Meeting of the Portuguese Society of Immunology Portuguese Society of Immunology (Lisbon, Portugal)
2004	TCR diversity and immune responses to transplantation	Transplant Grand Rounds Mayo Clinic (Rochester, United States)
2003/05	Delayed rejection of male to female skin grafts by memory like T cells	American Transplantation Congress, 2003, Washington, D.C., USA. American Transplantation Congress, (Washington, D.C., United States)
2002	NK cell non’Hodgkin Lymphoma: A clinico-pathology entity of the Middle line Lethal Granuloma – clinical case	XV National Meeting of ENT and Cervico-Facial Surgery National Society of ENT and Cervico-Facial Surgery (Aveiro, Portugal)
2001	Anemia and Dyserythropoiesis - CDA II	XIV Sabatin of Hematology, Coimbra Hospital Center, 2001 Centro Hospitalar e Universitário de Coimbra (Coimbra, Portugal)
2000	A case of Adult’s Still Disease	Intensive Care Portuguese Society Annual Simposum/First Santarém’s Congress of Intensive Care Intensive Care Portuguese Society (Santarém, Portugal)
2000	Paget’s Bone Disease associated with Myelofibrosis with Myeloid Metaplasia	6th National Congress of Internal Medicine National Congress of Internal Medicine (Porto, Portugal)
1999/11	Review of 6 cases of Kikushi-Fugimoto Disease	Annual Meeting of the Portuguese Society of Hematology Portuguese Society of Hematology (Estoril, Portugal)

Supervision

	Thesis Title Role	Degree Subject (Type) Institution / Organization
2020/11/09 - Current	Integration of neuronal signals by tumour-infiltrating natural killer and myeloma cells - NeuriMM Supervisor of Ana Filipa Barahona Afonso Tavares Cardoso	PhD in Biomedicine (PhD) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2020/09/14 - Current	Combined GEnetic and immuNe signatures associated with depth of response and Outcome in MultiplE Myeloma. Supervisor of Joana Filipa de Jesus Caetano	PhD in Health Sciences (PhD) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2021/01/01 - 2025/12/31	Combined immunotherapeutic approach for targeting bone marrow microenvironment in Multiple Myeloma. Supervisor of Ana Raquel Vicente Lopes	Programa Doutoral do Centro Académico de Medicina de Lisboa (ramo de Medicina; ramo de Ciências Biomédicas; ramo de Ciências e Tecnologias da Saúde) (PhD) Universidade de Lisboa Faculdade de Medicina, Portugal
2019/09/01 - 2021/03/31	Statistical methods for the study of extracellular vesicles content and their potential as biomarkers of multiple myeloma aggressiveness. Co-supervisor of Carolina Festas Pestana	Bioestatística (Master) Universidade de Lisboa Faculdade de Ciências, Portugal
2020/01/13 - 2020/02/21	Internship integrated in the Discipline of Introductory Program to Professional Practice Co-supervisor	Ciências de Engenharia Biomédica (Scientific initiation) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2019/03/01 - 2019/06/30	Research Project Discipline integrated in curriculum of the Bachelor in Medicine. Supervisor of Madalena Teixeira Santos de Sousa Gonçalves,	Medicina (Scientific initiation) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016 - 2019	Thymic function and regulatory T cells in the immune recovery of HIV infected patients. Funding FCT: PD/BD/106047/2015 Co-supervisor of Rita Ribeiro da Silva	Medicina (PhD) Universidade do Minho, Portugal
2017 - 2018	Atlas-based semi-automatic segmentation of Whole-Body DWI Images: Quantification of tumour burden Co-supervisor of Silvia Alexandra Dias Almeida	Ciências de Engenharia Biomédica (Master) Universidade Nova de Lisboa Faculdade de Ciências e Tecnologia, Portugal
2017 - 2017	The role of metastatic microenvironment in Multiple Myeloma extramedullary disease. Funding FCT: PTDC/MEC-HEM/30315/2017 Supervisor of Bruna Velosa Ferreira	Medicina (PhD) Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2017 - 2017	B cells modulation of T cells' function and repertoire: immune characterization of Non Hodgkin Lymphoma patients receiving chemotherapy, with or without the CD20 monoclonal antibody, Rituximab. Funding Associação Portuguesa Contra a Leucemia: APCL 2006-30.4M.AP/MJ Supervisor	Bioquímica (Master) Universidade de Évora Escola de Ciências e Tecnologia, Portugal

Event organisation

	Event name Type of event (Role)	Institution / Organization
2023/03/18 - Current	Member of the scientific and organizing committee of the "First National Meeting on Multiple Myeloma". (2023/03/18) Seminar (Member of the Scientific Committee)	Sociedade Portuguesa de Hematologia, Portugal
2021/09/01 - Current	Champalimaud Foundation Scientific Research Colloquium (2023/09/01) Seminar (Co-organisor)	Fundação Champalimaud, Portugal
2021/03/24 - 2021/03/24	Workshop: Sex and Gender Dimension in Your Research (2021/03/24 - 2021/03/24) Round table (Co-organisor)	Fundação Champalimaud, Portugal

Event participation

	Activity description Type of event	Event name Institution / Organization
2023/03/18 - Current	Speaker at the First National Meeting on Multiple Myeloma about "1st line treatment in multiple myeloma" Meeting	First National Meeting on Multiple Myeloma Sociedade Portuguesa de Hematologia, Portugal
2016/11/11 - Current	Invited speaker at the round table on "Immunotherapy": Lecture entitled "Immune mechanisms and intervention possibilities", Lisbon, Portugal Meeting	3º ABC em Imunologia para Médicos, Fundação Calouste Gulbenkian Hospital CUF Descobertas, Portugal
2016/10/08 - Current	Invited speaker in "Focusing on Remission in Multiple Myeloma" (Celgene Satellite Symposium), Milan, Italy Conference	3rd International Conference on Multiple Myeloma European School of Hematology, France
2016/02/12 - Current	Invited speaker on "New imaging strategies for diagnosis and staging on Multiple Myeloma and Lymphoma", Lisbon, Portugal Symposium	first ESOR/Champalimaud Foundation Symposium on “Imaging Hallmarks of Cancer” Fundação Champalimaud, Portugal
2015 - Current	Invited speaker in Immunology meeting entitled "Mecanismos Imunes e possibilidades de intervenção", Oeiras, Portugal Round table	ABC em Imunologia - Imunoterapia Instituto Gulbenkian de Ciência, Portugal
2015 - Current	Invited speaker in "Novas abordagens da LLC- ibrutinib"	CUF Infante Santo Hospital, Portugal
2022/11/10 - 2022/11/12	Speaker on "Emotional adjustment of the person with hemato-oncologic disease" at the round table entitled "Multidimensionality: Caring for the person with hemato-oncologic disease". Round table	Annual Meeting 2022 Sociedade Portuguesa de Hematologia, Portugal
2022/11/10 - 2022/11/12	Speaker at the Satellite Symposium on "BLENREP - Innovation in MM treatment: From studies to clinical practice". Symposium	Anual meeting 2022 Sociedade Portuguesa de Hematologia, Portugal
2021/10/06 - 2021/11/30	Invited Speaker at the Online Course Actualización en onconefrología organized by "La Sociedad Latinoamericana de Nefrología e Hipertensión (SLANH)" with the educational, IT and logistical management of EviMed. Módulo 5: Paraproteínas & Enfermedad Renal. Talk: Principios y novedades de la terapia anti-neoplásica en la GMSR https://redemc.net/campus/wp-content/uploads/2021/10/Programa-OncoNefro-ES_Campus-1.pdf Other	Online Course "Actualización en Onconefrología/ Update in Onconephology" EviMed Research Group LLC, United States
2021/11/11 - 2021/11/13	Invited Speaker at the Portuguese Society f Hematology Annual Meeting - Binding Site Symposium.: "Tecnologias inovadoras no diagnóstico e seguimento de precisão do Mieloma Múltiplo /Novel technologies to diagnose and monitor Multiple Myeloma" Meeting	Reunião Anual SPH 2021 Sociedade Portuguesa de Hematologia, Portugal
2021/11/01 - 2021/11/13	Invited Speaker at the Portuguese Society of Hematology Annual Meeting - Conference on the Educational Program: "Maintenance treatment for Multiple Myeloma". Meeting	Portuguese Society of Hematology Annual Meeting 2021 Sociedade Portuguesa de Hematologia, Portugal
2018/07/18 - 2018/07/21	Invited chairwoman at the ARVO-Champalimaud Foundation Ocular Oncogenesis & Oncology, Lisbon, Portugal Conference	Ocular Oncogenesis & Oncology Arvo Foundation for Eye Research, United States Fundação Champalimaud, Portugal
2016/10/28 - 2016/10/29	Invited speaker in ASKLEPIOS Course, Lisbon, Portugal Symposium	SYMPOSIUM ON IMAGING HALLMARKS OF CANCER – ESOR Fundação Champalimaud, Portugal European School of Radiology, Austria
2016/09/22 - 2016/09/23	Invited speacker in "Hematology Masterclass", Budapest, Hungary Seminar	Hematology Medical Education Program Janssen-Cilag Kft, Hungary
2016/02/08 - 2016/02/19	Invited speaker in a Hematology Debate Meeting, Vienna, Austria Meeting	Hematology Medical Education Program Janssen-Cilag Pharma GmbH, Austria
2016 - 2016	Invited speaker with lecture presentation: "New approaches from LLC- ibrutinib", Lisbon, Portugal Conference	7ª Reunião Anual da Associação Portuguesa de Farmácias Hospitalares, 2016 Associação Portuguesa de Farmácias Hospitalares, Portugal
2014 - 2014	Invited speaker with the titel "New therapies in Hemato-oncology and Immunotherapy and intra cellular signaling inhibition", Lisbon, Portugal Symposium	2014 Annual Meeting of the Portuguese Society of Human Genetics Sociedade Portuguesa de Genética Humana, Portugal

Jury of academic degree

	Topic Role	Candidate name (Type of degree) Institution / Organization
2023/11/22	Understanding the Role of Flower Code in Tumorigenesis Thesis Member	Dénise dos Reis da Rosa de Azevedo Camacho (PhD) Universidade Nova de Lisboa Instituto de Tecnologia Química e Biológica António Xavier, Portugal

Association member

	Society Organization name	Role
2016 - Current	International Myeloma Foundation	Membro activo
2014 - Current	International Multiple Myeloma Working Group	Membro activo
2009 - Current	European Hematology Association	Membro activo
2000 - Current	Portuguese Society of Hematology	Membro activo
1994 - 1994	Students Association of the Faculty of Medicine of University of Lisbon

Committee member

	Activity description Role	Institution / Organization
2023/05/01 - Current	Board Member of the EuroFlow Consortium Member	EuroFlow, Netherlands
2020/12/22 - 2020/12/22	Member of the jury for a doctoral thesis project in the Doctoral Program in Health Sciences at the University of Coimbra Member	Universidade de Coimbra, Portugal
1994 - 1995	Elected member of the Senate of the University of Lisbon Member

Conference scientific committee

	Conference name	Conference host
2024/03/01 - 2024/06/12	European Haematology Association Annual Meeting (EHA2024 Hybrid Congress - Myeloma and other Monoclonal gammopathies)	Madrid, Spain
2022/03/03 - 2022/03/14	European Haematology Association Annual Meeting (EHA2022 Hybrid Congress)	Vienna

Course / Discipline taught

	Academic session	Degree Subject (Type)	Institution / Organization
2023/04/11 - Current	Cancer immunotherapy - a global overview and clinical relevance	Doctoral Programme in Health Sciences - 14th edition (Doutoramento)	Universidade de Coimbra Faculdade de Medicina, Portugal
2023/02/23 - 2023/02/25	Immunology as a basis in the fight against multiple myeloma.	Perspectives in Hematology (Outros)	DNA Prime - Scientific Education, Portugal
2016 - 2021/04	Invited Professor of the Doctoral Program in Health Sciences - Oncobiology and Cancer Course	Curso de Oncobiologia e Cancro (Doutoramento)	Universidade de Coimbra Faculdade de Medicina, Portugal
2010 - 2020	Professor of Immunology	Medicina	Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2016/02/08 - 2016/02/19	Hematology Debate Meeting, Hematology Medical Education Program	Hematology Medical Education (Postgraduate Certificate)	Janssen-Cilag Pharma GmbH, Austria

Evaluation committee

	Activity description Role	Institution / Organization	Funding entity
2021/03/01 - Current	External Reviewer, PhD Scholarship call, FCT, PT Evaluator	Fundação para a Ciência e a Tecnologia, Portugal	Fundação para a Ciência e a Tecnologia
2015 - Current	Member of the Examination Jury for a position of specialist in clinical hematology at Centro Hospitalar do Algarve Evaluator	Centro Hospitalar do Algarve EPE, Portugal

Interview (tv / radio show)

	Program	Topic
2023/04/03 - Current	Médico da Casa /House Physician	Multiple Myeloma
2023/02/04 - Current	CNN Sábado	World Cancer Day is celebration (February 4th). The evolution in cancer therapies that have allowed a higher survival rate and a better quality of life for those diagnosed.
2019/03/07 - Current	Guest speaker in the tv programme "Edição da Manhã" (SIC)	Multiple Myeloma
2014/10/22 - Current	Guest speaker in the tv programme "Bom dia Portugal" (RTP)	Multiple Myeloma

Journal scientific committee

	Journal title (ISSN)	Publisher
2021/10/13 - Current	Cancers (2072-6694)	MDPI
2017/01/01 - Current	Cancers (2072-6694)	IMDP
2017/01/01 - Current	International Journal of Molecular Sciences (1422-0067)	IMDP
2017/01/01 - Current	Clinical Case Reports (2050-0904)	John Wiley & Sons Ltd
2017/01/01 - Current	OncoTargets and Therapy (1178-6930)	Dove Medical Press Ltd

Mentoring / Tutoring

	Topic	Student name
2019/08/19 - 2020/01/22	Short term internship	Catarina Ventura
2019/07/08 - 2019/08/31	Summer Internship	Jácome Toste

Distinctions

Award

2023	Women in Science Ciência Viva, Portugal
2022	Prize José Eduardo Guimarães - Best work in Hematology
2020	Award Innovate Competition; iMed Conference 13,0 Universidade Nova de Lisboa, Portugal
2019	Giled Génese Gilead Sciences Lda, Portugal
2004	Young Hematologist Award, Portuguese Society of Hematology Sociedade Portuguesa de Hematologia, Portugal

Title

2018	Consultant in Hematology ACSS- Administração Central do Sistema de Saude, Portugal

Other distinction

2011	Best Experimental Work Sociedade Portuguesa de Hematologia, Portugal
2009	2º Best Experimental Work - Poster Sociedade Portuguesa de Hematologia, Portugal
2003	1º Best Experimental Work - Poster Sociedade Portuguesa de Hematologia, Portugal
2003	Travel Award American Association of nephrology, United States