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Maria Leonor dos Santos Diniz Orge. Completed the PhD in Veterinary Sciences in 2005 by University of Trás-os-Montes and Alto Douro (UTAD) and graduated in Veterinary Medicine in 1996 by University of Lisbon. Is Coordinator of the Pathology Laboratory that includes several sectors: general pathology, bee pathology and Transmissible Spongiform Encephalopathies (TSEs) sector. Member of Workteam for Research and Diagnosis in TSE sector, Pathology Laboratory in Instituto Nacional de Investigação Agrária e Veterinária. Development and setup of procedures to improve the diagnosis methods and establishment of lesion profiles in veterinary neuropathology are the main research interests. Published 23 articles in journals. Has 8 section(s) of books. Organized 11 event(s). Co-supervised 2 PhD thesis(es). Supervised 1 MSc dissertation(s) e co-supervised 2. Participates and/or participated as Researcher in 11 project(s). Works in the area(s) of Agrarian Sciences with emphasis on Veterinary Sciences. In her curriculum Ciência Vitae the most frequent terms in the context of scientific and technological output are: prions and prion diseases; prnp gene; veterinary neuropathology; immunohistochemistry; ruminants.
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Identification

Personal identification

Full name
Maria Leonor dos Santos Diniz Orge

Citation names

  • Orge, Maria
  • Leonor Orge

Author identifiers

Ciência ID
F81E-B0E4-4DA9
ORCID iD
0000-0002-2673-2758

Email addresses

  • leonor.orge@iniav.pt (Professional)

Knowledge fields

  • Agrarian Sciences - Veterinary Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Intermediate (B1) Advanced (C1) Intermediate (B1) Intermediate (B1)
Spanish; Castilian Beginner (A1)
French Intermediate (B1) Beginner (A1)
Education
Degree Classification
2023/09/14 - 2023/09/14
Concluded
 Introducción a las Enfermedades Neurodegenerativas de los Animales Domésticos: Clasificación y Diagnóstico (Outros)
Davis Thomson DVM Foundation, United States
2023/05/18 - 2023/05/18
Concluded
 Serie de Seminarios de Histopatología del LCPG: Enfermedades Virales” (Outros)
Davis Thomson DVM Foundation, United States
2022/02 - 2022/02
Concluded
 Bugs, Pugs, and Drugs: An Overview of Inflammatory Neurologic Disorders (Outros)
Davis Thomson DVM Foundation, United States
2021/05 - 2021/05
Concluded
 Workshop Imunohistoquímica Digital (Outros)
Universidade do Porto Instituto de Patologia e Imunologia Molecular, Portugal
2021/01 - 2021/01
Concluded
 Webinar "El diagnostico en neuropatologia: más allá de la espongiose" (Outros)
Davis Thomson DVM Foundation, United States
2017/11 - 2017/11
Concluded
 Curso Teórico-prático-Patologia Forense Veterinária- Sociedade Portuguesa Patologia Animal (Outros)
Faculdade de Medicina Veterinária, Universidade de Lisboa, Portugal
2015/09 - 2015/09
Concluded
 Neuropathology Symposium (European Division) (Outros)
Davis Thomson DVM Foundation, United States
2014/10 - 2014/10
Concluded
 Workshop em Patologia Veterinária (Outros)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências Agrárias e Veterinárias, Portugal
2012/07 - 2012/07
Concluded
 Neuropatthology- Educational Module 11 (Outros)
British Society of Veterinary Pathology, United Kingdom
2012/04 - 2012/04
Concluded
 Curso de Neurologia em Animais de Companhia (Outros)
Universidade Lusofona-Faculdade de Medicina Veterinaria, Portugal
2011/06 - 2011/06
Concluded
 Workshop de Hibridação Cromogénica in situ (CISH) (Outros)
Faculdade de Medicina Veterinária, Universidade de Lisboa, Portugal
2008/07 - 2008/07
Concluded
 Professional training in TSE strain typing in mice (Outros)
Friedrich-Loeffler-Institut (FLI), Germany
2007 - 2007
Concluded
 Teaching Certificate Competence (CAP) nº EDF 437134/2007 DL (Outros)
Instituto do Emprego e Formação profissional, Instituto do Trabalho e da Solidariedade Social, Portugal
2006/11 - 2006/11
Concluded
 TSE strain typing by immunohistochemistry Neuroprion- Network of excellence of Prion Diseases (Outros)
Animal and Plant Health Agency, United Kingdom
2005/02 - 2005/02
Concluded
 Training Course for the Confirmatory and Discriminatory Western Blot TeSeETM sheep/goat (Outros)
Comissariat de Energie Atomic (CEA), , France, France
2005
Concluded
 Veterinary Medicine (Doutoramento)
Universidade de Trás-os-Montes e Alto Douro, Portugal
"BSE strain typing characterization in Portugal and determination of scrapie genetic susceptibility in Portuguese sheep " (THESIS/DISSERTATION)
 Aprovada com distinção e louvor
2003/09 - 2003/09
Concluded
 Veterinary Neuropathology Course, University of Bern (Outros)
European School of Advanced Veterinary Studies (ESAVS), Germany
2000/10 - 2000/10
Concluded
 Training Course for the BIORAD Platelia-BSE test for the Bovine Spongiform Encephalopathy Detection (Outros)
Institut Pasteur, France
2000/05 - 2000/05
Concluded
 Training Course for the Prionics¿-Check BSE-test Prionics AS (Outros)
Prionics AS, Switzerland
1998/10 - 1998/10
Concluded
 Vth International Workshop on the diagnosis of Spongiform Encephalopathies (Outros)
Animal and Plant Health Agency, United Kingdom
1996/10 - 1996/10
Concluded
 LEONARDO WORKSHOP: "Fish health management in Sea Bass and Sea Bream Farming" (Outros)
National Aquaculture Centre, Malta
1996
Concluded
 Medicina Veterinária (Licenciatura)
Universidade de Lisboa, Portugal
"Patologia do robalo (Dicentrarchus labrax (L)) em dulcicultura" (THESIS/DISSERTATION)
 Dezasseis valores
Affiliation

Science

Category
Host institution 		Employer
2015 - 2018 Auxiliary Researcher (Research) Centro de Ciência Animal e Veterinária, Portugal
2013 - 2013 Auxiliary Researcher (Research) Centro de Ciência Animal e Veterinária, Portugal

Others

Category
Host institution 		Employer
2010/01/11 - Current Coordinator of the Pathology Laboratory that includes several sectors: general pathology, bee pathology and TSEs sector. Development and setup of procedures to improve the diagnosis methods and stabli Instituto Nacional de Investigação Agrária e Veterinária, Portugal
1998/01/04 - Current Member of Workteam for Research and Diagnosis in TSE sector, Pathology Laboratory Instituto Nacional de Investigação Agrária e Veterinária, Portugal
1996/05/01 - 1997/12/31 Trainee in Pathology Department Instituto Nacional de Investigação Agrária e Veterinária, Portugal
Projects

Grant

Designation Funders
2019/10/07 - Current Uncovering the variability and regulation of prnp gene and their relevance in Chronic Wasting Disease susceptibility and transmission
SFRH/BD/146961/2019
Supervisor
CIC bioGUNE, Spain

Universidade de Trás-os-Montes e Alto Douro, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/10/01 - 2022/09/30 POCI-01-0145-FEDER-029947 "Chronic Wasting Disease risk assessment in Portugal (WastingPrionRisk)".
POCI-01-0145-FEDER029947
Co-Principal Investigator (Co-PI)
Instituto Nacional de Investigação Agrária e Veterinária, Portugal

Universidade de Trás-os-Montes e Alto Douro Escola de Ciências Agrárias e Veterinárias, Portugal

Instituto Politécnico de Castelo Branco Escola Superior Agrária, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2018 - 2021 Project ALG-01-0145-FEDER-028824 ” Antimicrobial Resistance Determinants in Aquaculture Environments (AquaRAM)”.
ALG-01-0145-FEDER-028824
Researcher
Instituto Nacional de Investigação Agrária e Veterinária, Portugal

Instituto Português do Mar e da Atmosfera, Portugal

Universidade de Lisboa Faculdade de Ciências, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2007 - 2013 M03058- Food Standards Agency. Infectivity and abnormal PrP in tissues from sheep exposed to atypical scrapie
M03058 FSA
Researcher
Concluded
2005 - 2008 POCTI/CVT/56668/2004 A Murine Neuroblastoma Cell-Based Approach to Study and Prevent Prion Diseases”
POCTI/CVT/56668/2004
Researcher
Concluded
2004 - 2007 Agro 558 Medida 8 – Acção 8.1 Agro Contribution for Scrapie epidemiological surveillance in Portugal
Agro 558
Concluded
2002 - 2005 Agro 84 Medida 8.1 AGRO Analysis and demonstration of Bovine Spongiform Encephalopathy histological images
Agro 84
Researcher
Concluded
1999 - 2002 FAIR PL 98-7021 The establishment of a European network for the surveillance of ruminant TSE and the standardization and harmonization of the process and criteria for the identification of suspect cases
FAIR PL 98-7021
Researcher
Concluded
1998 - 2000 PAMAF-IED 7046 Surveillance, Control and Eradication Plan of Bovine Spongiform Encephalopathy (BSE)
PAMAF-IED 7046
Researcher
Concluded

Contract

Designation Funders
2021/01/01 - 2025/12/31 Laboratório Associado para Ciência Animal e Veterinária
LA/P/0059/2020
10.54499/LA/P/0059/2020
Universidade de Trás-os-Montes e Alto Douro, Portugal

Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal

Universidade do Porto Instituto de Ciências Tecnologias e Agroambiente, Portugal

Universidade de Trás-os-Montes e Alto Douro Centro de Ciência Animal e Veterinária, Portugal

Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal

Universidade do Porto Centro de Estudos de Ciencia Animal, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/01/01 - 2023/01/31 COFUND - European Joint programme (EJP) - promoting One health in Europe through joint actions on foodborne zoonoses, antimicrobial resistance and emerging microbiological hazards
773830
Researcher
Ongoing
2020 - 2022 TOXOSOURCES- Toxoplasma gondii sources quantified (Joint Research Project within H2020 OneHealth EJP)
JRP22-FBZ4.1-TOXOSOURCES
Researcher
Concluded
2019/01/01 - 2019/12/31 Centro de Ciência Animal e Veterinária
UID/CVT/00772/2019
Universidade de Trás-os-Montes e Alto Douro Centro de Ciência Animal e Veterinária, Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2013 - 2015 CIPS/ISEC 2012 - IB-BIOALERTNET. Iberian Network of laboratories of biological alert. Accreditation of methods for detection of highly pathogenic agents.
CIPS/ISEC 2012 - IB-BIOALERTNET
Researcher
Concluded
2003 - 2009 FOOD-CT-2004-506579 Neuroprion- Network of excellence of Prion Diseases- 2 working groups 1) BSE &SCRAPIE- Risk assessment and control; 2) SHEEPEUROSTRAIN and 3) CERVIDS- TSEs in cervids (Team Member)
FOOD-CT-2004-506579
Researcher
Concluded
2002 - 2006 QLK5-CT-2002-0959 European Network for Surveillance and Control of TSE in Small Ruminants- SR TSE NETWORK
QLK5-CT-2002-0959
Researcher
Concluded
Outputs

Publications

Book chapter
  1. Orge, Maria. "TSE Monitoring in Wildlife Epidemiology, Transmission, Diagnosis, Genetics and Control". 2019.
    10.5772/intechopen.85797
  2. Leonor Orge; lima, carla; Ochoa, C.. "Capítulo 7- Necrópsia forense veterinária". In Descrição Anatomopatológica em Medicina Veterinária, edited by Pires, Maria dos Anjos; Payan-Carreira, Rita. Ed. Vila Real: UTAD ISBN: 978-989-704-220-1., 2016.
    Published
  3. Araujo Donato, Julia; Rodrigues Costa, Lucas; Gonçalves da Silva, Maria Carolina; de Paiva Castro, Priscila. "Capítulo 18- Descrição macro e microscópica das lesões do Sistema Nervoso Central de pequenos animais e ruminantes". In Descrição Anatomopatológica em Medicina Veterinária, edited by Pires, Maria dos Anjos; Payan-Carreira, Rita. Portugal: Ed. Vila Real: UTAD ISBN: 978-989-704-220-1, 2016.
    Published • 10.18225/9788570131621.cap2
  4. Leonor Orge; F.Loja. "Instalações, biosegurança e procedimentos operacionais no laboratório de diagnóstico molecular.". In Abordagens Moleculares em Veterinária - Como Desvendar a Etiologia e a Epidemiologia da Infeção, edited by Monica Cunha; João Inácio. In: Cunha M.V., Inácio J. (eds), LIDEL, Lisboa ., 2014.
    Published
  5. Leonor Orge. "EET’s.". In Laboratório Nacional de Investigação Veterinária, Uma Instituição Centenária 1913-2013. Portugal: In: Correa de Sá, I., Monteiro, M., Cruz, C., Neves Machado, C., Martins dos Santos, A. (eds) . INIAV, IP-9 de Julho de 2013. Vasp, 2013.
    Published
  6. Leonor Orge. "Encefalopatias Espongiformes Transmissíveis-Priões". In Microbiologia Médica. Portugal: Meliço-Silvestre A., Barroso H., Taveira N. (eds) Microbiologia Médica. LIDEL,, 2011.
  7. Leonor Orge; A.Galo, R. Santos; João Carvalho da Silva. ""Encefalopatia Espongiforme dos Bovinos- Diagnóstico"". In Manual de Inspecção Sanitária de Carnes- Aspectos Especiais. Portugal: da autoria do Dr Infante Gil, Fundação Calouste Gulbenkian., 2005.
    Published
  8. Alexandre Galo; Leonor Orge; Ricardo Santos; João Silva. "Diagnóstico Laboratorial da Encefalopatia Espongiforme dos bovinos". In Manual da Inspecção Sanitária das Carnes- Aspectos Especiais, edited by Infante Gil. Portugal: Fundação Calouste Gulbenkian, 2005.
    Published • 10.22533/at.ed.1071911029
  9. Leonor Orge. ""Encefalopatia Espongiforme dos Bovinos- Diagnóstico"". In II Volume,Manual de Inspecção Sanitária de Carnes- Aspectos Especiais. Portugal: da autoria do Dr Infante Gil, Fundação Calouste Gulbenkian, 2000.
    Published
Conference abstract
  1. Jorge Cláudio Pereira; Gonçalves-Anjo, Nuno; Bastos, Estela; Leonor Orge; Ana Cristina Matos; Adelina Gama; Anabela Alves; et al. Corresponding author: Jorge Cláudio Pereira. "Chronic wasting disease (CWD) risk assessment in Portugal: - The genetic approach to study prion protein gene (PRNP) variability in Portuguese populations of three cervid species: Red deer, Fallow deer and Roe deer". Paper presented in 10th Iberian Congress on Prions, Vila Real, 2022.
    Published
  2. Pires, Maria dos Anjos; Juan Maria Torres; Jorge C Pereira; Gonçalves-Anjo, Nuno; Bastos, Estela; Ana C Matos; Adelina Gama; et al. Corresponding author: Pires, Maria dos Anjos. "Chronic Wasting Disease Risk Assessment in Portugal. Results and Future work". Paper presented in 10th Iberian Congress on Prions, Vila Real, 2022.
    Published
  3. T Nogueira; A Amaro; AC Ferreira; S Cavaco-Gonçalves; T Albuquerque; P Anacleto; A Maulvaut; et al. "Antimicrobial reistence determinants in bivalves aquaculture". Paper presented in 1º SIMPÓSIO INIAV PARA A SEGURANÇA ALIMENTAR RUMO À ALIMENTAÇÃO DO FUTURO, 2019.
    Published
Conference poster
  1. Orge, L., Pereira, J., Gonçalves-Anjo, N., Aranha, J., Cabral, J.A., Bastos, E., Pires, M.A. and Vieira-Pinto, M.. "CWD in Europe: risk of introduction in Portugal". Paper presented in Prion 2023Conference, 2023.
  2. Sara Canoyra, Alba Marín-Moreno, Juan Carlos Espinosa, Natalia Fernández-Borges, Nuria Jerez-Garrido, Sylvie L. Benestad. "Evolution of Nor98/ Atypical scrapie by iterative propagation in a homologous ovine PrPC context". Paper presented in Prion 2023 Conference, 2023.
  3. ] P. Mendonça, P. Carvalho, L. Orge, M. Monteiro, A. Azevedo, M.P. Teixeira and M.J. Fraqueza. "Fatal septicaemic listeriosis in a golden-handed tamarin (Saguinus midas)". Paper presented in Joint ESVP-ECVP & ESVCP-ECVCP Congress, 2023.
  4. Monteiro, M., Carvalho, P., Mendonça, P., Orge, L., Fagulha, T., Henriques, A.M., Duarte, M.. "Infeção pelo vírus da gripe aviária do subtipo h5n1 de alta patogenicidade: caracterização das lesões observadas". Paper presented in 10º Encontro de Formação da Ordem dos Médicos Veterinários, 2023.
  5. Orge, L., Pereira, J., Gonçalves-Anjo, N., Aranha, J., Cabral, J. A., Bastos, E., Pires, M.A. and Vieira-Pinto, M.. "Doença emaciante crónica dos cervídeos emergente na europa - risco de introdução em Portugal?". Paper presented in 10º Encontro de Formação da Ordem dos Médicos Veterinários, 2023.
  6. Carvalho, P., Mendonça, P., Orge, L. e Monteiro, M.. "Lipomatose torácica como causa de morte súbita numa cobaia (Cavia porcellus).". Paper presented in 10º Encontro de Formação da Ordem dos Médicos Veterinários, 2023.
  7. Gonçalves-Anjo, Nuno; Jorge C Pereira; Ana Machado; Mafalda Saianda; Bastos, Estela; Ana C Matos; Gama, Adelina; et al. Corresponding author: Gonçalves-Anjo, Nuno. "Chronic wasting disease risk assessment in Portugal: analysis of variability and genetic structure of the Portuguese roe deer population". Paper presented in Prion 2022 Conference, 2022.
  8. Jorge C Pereira; Gonçalves-Anjo, Nuno; Bastos, Estela; Leonor Orge; Ana C Matos; Adelina Gama; Anabela Alves; et al. Corresponding author: Jorge C Pereira. "Determining prion protein gene (PRNP) genetic variability in Portuguese cervidae population. An important task in chronic wasting disease (CWD) risk assessment project in Portugal". Paper presented in Prion 2022 Conference, 2022.
  9. F. Songa; V. Kovac; B. Mohammadia; M. Shafiqa; A. Matamoros-Angles; S. Djakkania; F. Scharfenberg; L. Orge ; I. Vanni; R. "The ADAM10-mediated shedding of PrP in the human system: Cleavage site identification, antibody characterization, (patho)physiological insight and some peculiarities". Paper presented in Prion 2022 Conference, 2022.
  10. "Estimating sequence diversity of prion protein gene (prnp) in portuguese populations of two cervid species: red deer and fallow deer". Paper presented in 9th Iberian Congress on Prions, 2021.
  11. "Molecular Genetics Approaches – current state of Chronic Wasting Disease in Portugal". Paper presented in International Meeting of the Portuguese Society of Genetics - XLIII Jornadas Portuguesas de Genética, 2020.
  12. "Human and animal Prion Diseases in Portugal – Who is the model?". Paper presented in Meeting of the Portuguese Society of Genetics - XLIII Jornadas Portuguesas de Genética, 2020.
  13. "In silico metagenomic comparison of antimicrobial resistance profiles in aquaculture environments". Paper presented in 4th Aquaimprove Workshop CIIMAR,, 2019.
  14. "Antimicrobial resistance determinants in bivalves aquaculture". Paper presented in 1º Simpósio INIAV para a Segurança Alimentar, 2019.
  15. "Lesões neuropatológicas observadas em espécies animais silvestres". Paper presented in XXIV Encontro da Sociedade Portuguesa de Patologia Animal, Patologia de Espécies Exóticas, Silvestres e Cinegéticas, 2019.
  16. "Doença emaciante crónica dos cervídeos- qual o risco em Portugal?,". Paper presented in Wildlife & Game Management Innovation Summit, 2019.
  17. "Chronic Wasting Disease – Characterization of prnp gene in Portuguese cervids". Paper presented in Jornadas de Genética e Biotecnologia, UTAD e Universidade de Léon, 2019.
  18. "Chronic wasting disease risk assessment in Portugal - setting up a Project". Paper presented in 7th Iberian Congress on Prions, 2018.
  19. P. Pacheco; Leonor Orge; M. Head; P. Loureiro, C; Silva, João; Ironside, A; A. Galo; G. Coito; C. Ventura. "Novel Prion Disease Mutation R136S has an incomplete penetrance dependent upon codon 129 trans allele". Paper presented in Prion 2006, Stratagies, advances and trends towards protection of society, Turim, Itália, 2006.
  20. Leonor Orge; João Silva; Carla Neves; M. Azevedo Ramos. "BSE Active Surveillance in portugal". Paper presented in Food Safety, Porto, Portugal, 2002.
  21. Leonor Orge; A. Fernandes; Carla Lima; João Silva; Carla Neves; M. Azevedo Ramos; Alexandre Galo. "Lesion Profile and PrPres distribution in BSE Active Surveillance". Paper presented in TSE International Conference, Edimburgo, Reino Unido, 2002.
  22. Leonor Orge; João Silva; Carla Neves; A. Fernandes; Carla Lima; Paula Tavares; Paula Almeida; M. Azevedo Ramos; Alexandre Galo. "Diagnóstico Laboratorial no controlo das TSEs animais". Paper presented in Congresso de Ciências Veterinárias, Oeiras, Portugal, 2002.
  23. João Silva; Miguel Santos; Leonor Orge; Ricardo Santos; A. Ramos; H. Ferreira; A. Fernandes; Alexandre Galo; J. Costa. "PCR Detection of Bovine Mithocondrial DNA in Meat and Bone Meal". Paper presented in Foodborn Illness, Porto, Portugal, 1999.
Journal article
  1. Jorge Pereira; Nuno Gonçalves-Anjo; Leonor Orge; Maria A. Pires; Sara Rocha; Luís Figueira; Ana C. Matos; et al. "Estimating sequence diversity of prion protein gene ( PRNP ) in Portuguese populations of two cervid species: red deer and fallow deer". Prion (2023): http://dx.doi.org/10.1080/19336896.2023.2191540.
    10.1080/19336896.2023.2191540
  2. Martha Ynés Salas-Fajardo; Julio Benavides; Alexandre Azevedo; Paulo Figueiras; Madalena Monteiro; Leonor Orge; Paula Mendonça; et al. "Fatal toxoplasmosis in a captive squirrel monkey (Saimiri boliviensis) in Portugal". Veterinary Research Communications (2023): http://dx.doi.org/10.1007/s11259-023-10179-x.
    10.1007/s11259-023-10179-x
  3. Leonor Orge; Maria de Lurdes Pinto; Paula Cristovão; Paula Mendonça; Paulo Carvalho; Carla Lima; Helena Santos; et al. "Detection of Abnormal Prion Protein by Immunohistochemistry". Journal of Visualized Experiments 195 (2023): http://dx.doi.org/10.3791/64560.
    10.3791/64560
  4. Alexandra Esteves; Madalena Vieira-Pinto; Hélder Quintas; Leonor Orge; Adelina Gama; Anabela Alves; Fernanda Seixas; et al. "Scrapie at Abattoir: Monitoring, Control, and Differential Diagnosis of Wasting Conditions during Meat Inspection". Animals 11 11 (2021): 3028-3028. https://doi.org/10.3390/ani11113028.
    10.3390/ani11113028
  5. Mafalda Casanova; Carla Machado; Paula Tavares; João Silva; Christine Fast; Anne Balkema-Buschmann; Martin H. Groschup; Leonor Orge. "Circulation of Nor98 Atypical Scrapie in Portuguese Sheep Confirmed by Transmission of Isolates into Transgenic Ovine ARQ-PrP Mice". International Journal of Molecular Sciences (2021): https://doi.org/10.3390/ijms221910441.
    10.3390/ijms221910441
  6. Marín-Moreno A; Aguilar-Calvo P; Espinosa JC; Zamora-Ceballos M; Pitarch JL; González L; Fernández-Borges N; et al. "Classical scrapie in small ruminants is caused by at least four different prion strains.". Veterinary research (2021): http://europepmc.org/abstract/med/33858518.
    10.1186/s13567-021-00929-7
  7. Leonor Orge; Carla Lima; Carla Machado; Paula Tavares; Paula Mendonça; Paulo Carvalho; João Silva; et al. "Neuropathology of Animal Prion Diseases". Biomolecules 11 3 (2021): 466-466. https://doi.org/10.3390/biom11030466.
    10.3390/biom11030466
  8. Pinto, Maria Lurdes; Orge, Leonor; Pires, Maria dos Anjos; Requena, Jesús R.. "Editorial: The Design of Molecular Tools in Relation to Prions and Their Biosafety". Frontiers in Bioengineering and Biotechnology 8 (2021): http://dx.doi.org/10.3389/fbioe.2020.638513.
    Open access • Published • 10.3389/fbioe.2020.638513
  9. Orge, Maria. "The emergence of classical BSE from atypical/Nor98 scrapie". Proceedings of the National Academy of Sciences (2019): http://dx.doi.org/10.1073/pnas.1915737116.
    10.1073/pnas.1915737116
  10. Pires MA; Catarino J; Vilhena H; Faim S; Neves T; Freire A; Seixas F; Orge L; Payan-Carreira R. "Co-existing monophasic teratoma and uterine adenocarcinoma in a female dog.". Reproduction in domestic animals = Zuchthygiene (2019): http://europepmc.org/abstract/med/30907028.
    10.1111/rda.13430
  11. Noiva R; Ruivo P; de Carvalho LM; Fonseca C; Fevereiro M; Carvalho P; Orge L; Monteiro M; Peleteiro MC. "First description of a fatal equine infection with Halicephalobus gingivalis in Portugal. Relevance for public health.". Veterinary medicine and science (2019): http://europepmc.org/abstract/med/30672155.
    10.1002/vms3.142
  12. Patricia Aguilar-Calvo; Juan-Carlos Espinosa; Olivier Andréoletti; Lorenzo González; Leonor Orge; Ramón Juste; Juan-María Torres. "Goat K222-PrPC polymorphic variant does not provide resistance to atypical scrapie in transgenic mice". Veterinary Research 47 1 (2016): http://dx.doi.org/10.1186/s13567-016-0380-7.
    10.1186/s13567-016-0380-7
  13. Orge L; Simas JP. "Response to commentary on "Identification of H-type BSE in Portugal".". Prion (2016): http://europepmc.org/abstract/med/27802081.
    10.1080/19336896.2016.1220798
  14. Gouveia, A.J.; Orge, L.; Carvalho, P.. "The size of amygdala and aggressiveness in fighting bulls | A dimensão da amígdala cerebral e a agressividade no touro de lide". Archivos de Zootecnia 65 249 (2016): 59-65. http://www.scopus.com/inward/record.url?eid=2-s2.0-84961855252&partnerID=MN8TOARS.
  15. Orge, Maria. "Identification of H-type BSE in Portugal". Prion 9 1 (2015): 22-28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601389/.
    10.1080/19336896.2014.997615
  16. Orge, Maria Leonor; Oliveira, Ana; Machado, Carla Guedes; Carvalho, Renata; Silva, Joao; Tavares, Paula; Almeida, Paula; et al. "Intensive surveillance in atypical scrapie affected flocks-Results and impact". Prion 6 (2012): 69-70. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000304234300145&KeyUID=WOS:000304234300145.
  17. Andréoletti, O.; Orge, L.; Benestad, S.L.; Beringue, V.; Litaise, C.; Simon, S.; Le Dur, A.; et al. "Atypical/Nor98 scrapie infectivity in sheep peripheral tissues". PLoS Pathogens 7 2 (2011): http://www.scopus.com/inward/record.url?eid=2-s2.0-79952219556&partnerID=MN8TOARS.
    10.1371/journal.ppat.1001285
  18. Machado, Carla; Oliveira, Ana; Lima, Carla; Tavares, Paula; Almeida, Paula; Ochoa, Cristina; Silva, Joao; et al. "Atypical Scrapie in Goats-Pathological and Epidemiological Characterization and Relevance". Prion 4 3 (2010): 142-142. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285872300084&KeyUID=WOS:000285872300084.
  19. Lacroux, Caroline; Orge, Leonor; Benestad, Sylvie L.; Beringue, Vincent; Litaise, Claire; Simon, Stephanie; Simmons, Hugh; et al. "A Typical/Nor98 Scrapie Infectivity in Sheep Peripheral Tissues". Prion 4 3 (2010): 149-149. http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000285872300101&KeyUID=WOS:000285872300101.
  20. Orge, L.; Oliveira, A.; Machado, C.; Lima, C.; Ochoa, C.; Silva, J.; Carvalho, R.; et al. "Putative emergence of classical scrapie in a background of enzootic atypical scrapie". Journal of General Virology 91 6 (2010): 1646-1650. http://www.scopus.com/inward/record.url?eid=2-s2.0-77952695834&partnerID=MN8TOARS.
    10.1099/vir.0.018879-0
  21. Fediaevsky, A.; Maurella, C.; Nöremark, M.; Ingravalle, F.; Thorgeirsdottir, S.; Orge, L.; Poizat, R.; et al. "The prevalence of atypical scrapie in sheep from positive flocks is not higher than in the general sheep population in 11 European countries". BMC Veterinary Research 6 (2010): http://www.scopus.com/inward/record.url?eid=2-s2.0-77951902058&partnerID=MN8TOARS.
    10.1186/1746-6148-6-9
  22. Orge, L.; Galo, A.; Machado, C.; Lima, C.; Ochoa, C.; Silva, J.; Ramos, M.; Simas, J.P.. "Identification of putative atypical scrapie in sheep in Portugal". Journal of General Virology 85 11 (2004): 3487-3491. http://www.scopus.com/inward/record.url?eid=2-s2.0-7444263581&partnerID=MN8TOARS.
    10.1099/vir.0.80246-0
  23. Orge L; Galo A; Sepúlveda N; Simas JP; Pires M. "Scrapie genetic susceptibility in Portuguese sheep breeds.". The Veterinary record (2003): http://europepmc.org/abstract/med/14601805.
  24. Orge, L.; Galo, A.; Sepúlveda, N.; Simas, J.P.; Pires, M.. "Scrapie genetic susceptibility in Portuguese sheep breeds [6]". Veterinary Record 153 16 (2003): http://www.scopus.com/inward/record.url?eid=2-s2.0-0142211452&partnerID=MN8TOARS.
  25. Leonor Orge; Alexandre Galo; Nuno Sepúlveda; Pires, Maria dos Anjos. "Scrapies genetic susceptibility in Portuguese sheep breeds". Veterinary Record 153 16 (2003): 508-508.
    Published
  26. Orge, L.; Simas, J.P.; Fernandes, A.C.; Ramos, M.; Galo, A.. "Similarity of the lesion profile of BSE in Portuguese cattle to that described in British cattle". Veterinary Record 147 17 (2000): 486-488. http://www.scopus.com/inward/record.url?eid=2-s2.0-0034699860&partnerID=MN8TOARS.
  27. Leonor Orge; M. P. CRUZ E SILVA; M. S. GRAZINA FREITAS. "Co-Infection by Monogenetic Trematodes of the Genus Microcotyle V. BENEDEN & HESSE, 1863, Lamellodiscus ignoratus PALOMBI, 1943, the Protozoan Trichodina sp. EHNRENBERG, 1838, and the presence of Epitheliocystis, Vibrio algynoliticus and V. vulnificus in cultured Seabream (Sparus aurata L.) in Portugal"". Bull. Eur. Ass. Fish Pathol. 17 2 (1997): 40-42.
    Published
Journal issue
  1. Leonor Orge; Carla Guedes Machado; João Silva; Renata Carvalho; Sofia Quintans; Rita Amador. "BSE e Scrapie em Portugal - Situação atual e oportunidades". Dossier técnico Vida Rural julho/agosto (2018):
    Published
Magazine article
  1. Leonor Orge; M. Vieira-Pinto; A. Gama; A.C. Matos; A. Alves; C. Lima; C. Machado,; E. Bastos, F. Seixas, F. Silva, I. Pires, J. Silva, J. Pereira, L. Figueira, M.L. Pinto, N. Anjo, P. Mendonç. "Doença Emaciante Crónica dos Cervídeos", Revista Caça e Cães de Caça, 2020
  2. Leonor Orge; Carla Guedes Machado; João Silva; Renata Carvalho; Sofia Quintans; Maria Rita Amador. "BSE e scrapie em Portugal- Situação atual e oportunidade .", Vida Rural, 2018
Preprint
  1. Jorge C. Pereira; Nuno Gonçalves-Anjo; Leonor Orge; Maria A. Pires; Sara Rocha; Luís Figueira; Ana C. Matos; et al. "Estimating sequence diversity of prion protein gene (PRNP) in Portuguese populations of two cervid species: red deer and fallow deer". 2022. https://doi.org/10.1101/2022.08.16.504133.
    10.1101/2022.08.16.504133
Thesis / Dissertation
  1. Leonor Orge. "Characterisation of the BSE strain in Portugal and study of ovine genetic susceptibility to scrapie". PhD, Universidade de Trás-os-Montes e Alto Douro Escola de Ciências Agrárias e Veterinárias, 2005.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10/03 Surveillance of prion diseases in Portuguese Cervids 20th Annual Meeting of the TSE EURL
Istituto Superiore di Sanità (Rome, Italy)
2022/05/18 Biossegurança em ambiente laboratorial: Procedimentos de emergências em caso de incidente/acidente de origem biológica Seminário organizado pelo Núcleo de Biossegurança da Universidade de Trás-os-Montes e Alto Douro
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)
2019/11/13 “Procedimentos de emergências em caso de incidente/acidente de origem biológica” VIII Workshop “Cenários em situações de emergência de origem biológica
Instituto Nacional de Saúde Ricardo Jorge (Lisboa, Portugal)
2019/10/25 “Chronic wasting disease risk assessment in Portugal - Genetic variability preliminary results and future perspectives” 8th Iberian Prion Congress
Instituto Politécnico de Castelo Branco-Escola Superior Agrária de Castelo Branco (Castelo Branco, Portugal)
2019/10/24 “Characterization of the first Portuguese cases of Atypical Scrapie in transgenic ovine ARQ-PrP mice” 8th Iberian Prion Congress
Instituto Politécnico de Castelo Branco-Escola Superior Agrária (Castelo Branco, Portugal)
2019/06/15 Criptococose sistémica em psitacídeos XXIV Meeting of the Portuguese Society of Pathology- Pathology of Exotic, Wildlife, and Game Animals
Universidade de Trás-os-Montes e Alto Douro (Vila Real, Portugal)

Supervision

Thesis Title
Role 		Degree Subject (Type)
Institution / Organization
2022/01 - 2025/01 Impact of stress factors on the virulence of neurotropic and non-neurotropic Listeria monocytogenes strains from the ruminant meat chain
Co-supervisor of Maria Pedro Ribeiro Teixeira
Universidade de Lisboa Centro de Investigação Interdisciplinar em Sanidade Animal, Portugal
2019 - 2022 “Uncovering the variability and regulation of prnp gene and their relevance in Chronic Wasting Disease susceptibility and transmission” bolsa de Doutoramento SFRH/BD/146961/2019
Co-supervisor
 Genética Molecular Comparativa e Tecnológica (PhD)
Universidade de Trás-os-Montes e Alto Douro Escola de Ciências da Vida e do Ambiente, Portugal
2019 - 2019 Execução do teste de despistagem rápida para diagnóstico das EETs
Co-supervisor
 Microbiology and Molecular Biology
Escola Superior de Saúde Egas Moniz (Bacharelato em Ctesp de Microbiologia e Biologia Molecular), Portugal
2018 - 2019 Prognostic Value of Volume-Weighted Mean Nuclear Volume in Canine Mast Cell Tumours
Co-supervisor
 Medicina Veterinária (Master)
Universidade de Évora, Portugal
2017 - 2017 Professional training courses in TSE rapid testing and related quality internal control in histopathology
Supervisor
2013 - 2014 Retrospective study of scrapie in Portugal
Supervisor
 Medicina Veterinária (Master)
Universidade de Lisboa Faculdade de Medicina Veterinária, Portugal
2013 - 2013 Caracterização das suspeitas de envenenamento em animais domésticos (cães e gatos) no norte e centro de Portugal durante o período de 2004 a 2011
Co-supervisor
Universidade do Porto Instituto de Ciências Biomédicas Abel Salazar, Portugal

Event organisation

Event name
Type of event (Role) 		Institution / Organization
2023/01 - 2023/10 Prion2023 Conference (https://prion2023.org/) (2023/10/16 - 2023/10/20)
Congress (Member of the Organising Committee)
 Universidade do Algarve - Campus de Gambelas, Portugal
2022/09 - 2022/11 Seminar on Avian Flu (https://events.iniav.pt/GripeDasAves/) (2022/11/03 - 2022/11/03)
Seminar (Member of the Organising Committee)
 Sociedade Portuguesa de Ciências Veterinárias, Portugal
2022/01 - 2022/07 XXV Meeting of the Portuguese Society of Animal Pathology - Veterinary Forensic Medicine (https://events.iniav.pt/sppa2022/) (2022/06/30 - 2022/07/01)
Seminar (Member of the Organising Committee)
 Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2022/01 - 2022/05/20 10th Iberian Congress on Prions (https://wastingprionrisk.pt/en/congresso-english/ (2022/05/19 - 2022/05/20)
Congress (Member of the Organising Committee)
 Universidade de Trás-os-Montes e Alto Douro Centro de Ciência Animal e Veterinária, Portugal
2019 - 2019 8th Iberian Prion Congress (2019/10/24 - 2019/10/25)
Congress (Co-organisor)
 Instituto Politécnico de Castelo Branco Escola Superior Agrária, Portugal

Instituto Nacional de Investigação Agrária e Veterinária, Portugal

Universidade de Trás-os-Montes e Alto Douro, Portugal
2018 - 2018 PRION2018 (2018 - 2018)
Congress (Member of the Scientific Committee)
 Universidade de Santiago de Compostela, Spain
2018 - 2018 7th Iberian Prion Congress (2018 - 2018)
Congress (Member of the Scientific Committee)
 CIC bioGUNE, Spain
2017 - 2017 6th Iberian Prion Congress (2017 - 2017)
Congress (Member of the Scientific Committee)
 Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Spain
2016 - 2016 5th Iberian Prion Congress (2016 - 2016)
Congress (Member of the Scientific Committee)
 Universitat Autònoma de Barcelona, Spain
2015 - 2015 4th Iberian Prion Congress (2015 - 2015)
Congress (Member of the Organising Committee)
 Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2013 - 2013 2nd Iberian Prion Congress (2013 - 2013)
Congress (Member of the Scientific Committee)
 Universidade do Algarve - Campus de Gambelas, Portugal
2012 - 2012 1st Iberian Prion Congress (2012 - 2012)
Congress (Member of the Scientific Committee)
 Universidade de Santiago de Compostela, Spain
2009 - 2009 Meeting of the Working Group “TSE strain styping” Neuroprion (Network of excellence of Prion Diseases) (2009 - 2009)
Meeting (Member of the Organising Committee)
2007 - 2007 International Seminar “Contribution for the Epidemiological Surveillance of scrapie” (Projeto Agro 558) (2007 - 2007)
Seminar (Member of the Organising Committee)
2005 - 2005 II Seminário Internacional sobre TSEs, Projeto Agro nº84 Medida 8 Acção 8.1. D.E.&D. (2005 - 2005)
Seminar (Member of the Organising Committee)
 Universidade de Trás-os-Montes e Alto Douro Escola de Ciências Agrárias e Veterinárias, Portugal

Jury of academic degree

Topic
Role 		Candidate name (Type of degree)
Institution / Organization
2023/10/23 Estudio de los factores implicados en la transmisión, susceptibilidad genética y diágnostico de las enfermedades priónicas
(Thesis) Arguer
 Diego sola (PhD)
Faculdade de Medicina Veterinária, Universidade de Saragoça, Spain
2022/11/11 Contribuciones al estudio de biomarcadores, terapia y fenómeno de cepas en las enfermedades priónicas
President of the jury
 Marina Betancor Caro (PhD)
Faculdade de Medicina Veterinária, Universidade de Saragoça, Spain
2020 Molecular elements involved in replication and transmission of prions
Thesis Member
 Maria Alba Moreno (PhD)
Universidad Autónoma de Madrid, Facultad de Ciencias , Spain
2020 Valoracion de la respuesta inflamatória en el scrapie como protótipo de enfermedad prionica
President of the jury
 Isabel Mª Guijarro Torvisco (PhD)
2016 Aportaciones al estudio de la Patogenia y aspectos genéticos de las Encefalopatías espongiformes Transmisibles en rumiantes
(Thesis) Arguer
 José Luis Pitarch Moré (PhD)
Faculdade de Medicina Veterinária, Universidade de Saragoça, Spain
2013 Insights into the role of “prion –like” genes and proteins on scrapie susceptibility and ram fertility
(Thesis) Arguer
 Jorge Manuel Botelho Garcia Andrade Pimenta (PhD)
Faculdade de Medicina Veterinária, Universidade de Lisboa, Portugal
2008 Caracterização neuropatológica do envelhecimento nos canídeos
(Thesis) Main arguer
 Carla Maria Teixeira e Lima (Master)
Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto , Portugal
2006 Identification of polymorphisms and characterization of new ovine growth hormone variants associated with milk traits in “Serra da Estrela” ovine breed
(Thesis) Arguer
 Maria do Rosário Fernandes Marques (PhD)
Faculdade de Engenharia de Recursos Naturais, Universidade do Algarve , Portugal

Association member

Society Organization name Role
2011 - Current Portuguese Society of Veterinary Sciences- nº 2427
1997 - Current National Order of Veterinary Doctors- nº 1835

Committee member

Activity description
Role 		Institution / Organization
2017 - Current Technical Commmitee nº 207 from Portuguese Institute for Quality to elaborate a national procedure related to Biosafety and Biosecurity in Laboratories
Member
 Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2012 - Current Member of the Coordinator Commission of the Scientific Council of INIAV representing Pathology
Member
 Instituto Nacional de Investigação Agrária e Veterinária, Portugal
2011 - Current Portuguese Biosafety Network LabPTBioNet - network of Portuguese biosafety laboratories level- 3
Member
 Instituto Nacional de Investigação Agrária e Veterinária, Portugal

Conference scientific committee

Conference name Conference host
2023/10/16 - 2023/10/20 Prion 2023 Conference University of Algarve
2023/05/11 - 2023/05/12 11th Iberian Congress on Prions 2023 University of Barcelona
2022/05/19 - 2022/05/20 10th Iberian Congress on Prions 2022 Universidade de Trás-os-Montes e Alto Douro
2019 - 2019/11 8th Iberian Prion Congress Instituto Politécnico de Castelo Branco

Course / Discipline taught

Academic session Degree Subject (Type) Institution / Organization
2015 - Current 5 Seminars on TSEs in Veterinary Master Course, Universidade de Évora (December 2019; December 2018; May 2018; December 2016; December 2015). Veterinary Medicine (Mestrado) Universidade de Évora Instituto de Ciências Agrárias e Ambientais Mediterrânicas, Portugal
2014/11 - 2017/11 4 Training Courses “Laboratory confirmation and characterization of TSE cases in bovine and small ruminants- Prevention, Control and eradication of Transmissible Spongiform encephalopathies- Training session 4” Better Training for Safer food (Outros) JVL Consulting, Belgium

Journal scientific committee

Journal title (ISSN) Publisher
2019/10/08 - 2020/06/17 Frontiers in Bioengineering and Biotechnology (2296-4185) Frontiers Media SA

Mentoring / Tutoring

Topic Student name
2023/05 - 2023/06 Veterinary Pathology Rodrigo Dias Pinto da Silva Santos
2023/05 - 2023/06 TSE diagnosis methods Deusa Tavares