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Carla Nunes is an Assistant Professor at Vasco da Gama University School (EUVG) and also an Invited Assistant Professor on a part-time basis at FFUC. Additionally, she is a researcher at the Center for Neurosciences and Cell Biology (CNC), University of Coimbra. Carla has a degree in Pharmaceutical Sciences (1998), having received the award of the best student, a MsC degree in Cell Biology (2003) and a Ph.D. in Pharmacy, specializing of Biochemistry (2008), all from the University of Coimbra, Portugal. Throughout her career, Carla's research has been centered on unraveling and modulating dysfunctional molecular mechanisms associated with chronic diseases. Notably, during her Ph.D., she made a groundbreaking discovery by demonstrating that mitochondrial dysfunction induced by the combined action of Nitric Oxide and DOPAC may play a significant role in the neurodegeneration observed in Parkinson's disease. Following a four-year hiatus in her scientific pursuits (2006-2009), Carla obtained a highly competitive FCT postdoctoral fellowship, marking her reentry into academia. She started a new research line within the "Redox Biology in Health and Disease" group of the CNC, dedicated to exploring the molecular mechanisms underlying the anti-inflammatory effects of dietary polyphenols. Concurrently, she engaged in teaching activities at FFUC courses (2011-2014). Following the conclusion of her postdoctoral in 2015, Carla accepted a precarious position as an Invited Assistant Professor. In December 2019, Carla obtained a post-doctoral fellowship from the University of Coimbra, under the HealthyAging2020 project, focusing on studying the impact of diet in preventing cognitive deficits associated with neurodegeneration. Between September 2021 and July 2022, she was contracted as a researcher under the project "Monitoring neurometabolic markers in vivo using microelectrode-based biosensors." In this context, her work focused on the development of biosensors for monitoring various metabolites, namely glucose, lactate, and pyruvate, in biological samples and in vivo. This work resulted in the development of an innovative biosensor for lactate measurement, particularly in plasma, whose patent application is currently pending. Throughout her years of work, she has been involved in guiding, training, and mentoring undergraduate and master’s students. Notably, she has officially supervised 12 MSc dissertations, co-supervised 1 and supervised the scientific project leading to the completion of a Biochemistry degree. Currently, she supervised 2 MSc dissertation and the laboratory work of a master student within the curriculum of Integrated Veterinary Practice II. Furthermore, she is actively mentoring 6 students enrolled in Integrated Veterinary Practice I and II. She participated as a researcher and team member in 13 funded projects. Presently, she is deeply engaged in the international Project “MicroMundo”. Despite encountering some interruptions in her scientific journey, Carla Nunes published 16 conference abstracts, 1 book chapter and a total of 20 papers, including 15 Original Contributions and 5 Reviews, with 11 papers as the first author. Of these, 8 papers are in Q1 of their respective research areas, with 1 in the top 10% and 4 in the top 20%. Additionally, 4 of her papers have been featured among the most cited/downloaded articles, and 2 papers were accepted without requiring revisions. Her primary research areas encompass Biochemistry and Molecular Biology, Food Science Technology and Pharmacology/Pharmacy. Furthermore, Carla has contributed 2 papers to magazines targeting general readerships. In their professional activities interacted with 74 collaborator(s) co-authorship of scientific papers. She has received 9 awards and/or honors. Carla Nunes is regularly invited to review papers for various scientific journals and frequently participates in academic juries, where she serves as the main arguer.
Identification

Personal identification

Full name
Carla Maria dos Santos Nunes

Citation names

  • Nunes, Carla

Author identifiers

Ciência ID
F91E-D4F7-AC2D
ORCID iD
0000-0002-7452-1592

Email addresses

  • carla.nunes@euvg.pt (Professional)
  • carlapumky@gmail.com (Personal)

Knowledge fields

  • Medical and Health Sciences - Health Sciences
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy
  • Natural sciences - Biological Sciences - Cell Biology
  • Natural sciences - Biological Sciences - Biochemistry
  • Medical and Health Sciences - Health Sciences - Nutrition, Dietetics
Education
Degree Classification
2021/05/18 - 2021/05/20
Concluded
Tissue Clearing Online Workshop (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2020/11/09 - 2020/11/20
Concluded
Laboratory Animal Science course (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
a final grade of 17 values out of 20
2020/11/09 - 2020/11/20
Concluded
Laboratory Animal Science Course - special skills (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
a final grade of 18,5 values out of 20
2012/10 - 2015/08
Concluded
Red wine polyphenols as novel antimicrobial agents: molecular mechanisms involved in the protection against pathogenic intestinal bacteria (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2009/10 - 2012/09
Concluded
Prevention of inflammatory processes in gastrointestinal epithelia by dietary flavonoids via modulation of Nrf2 and nitric oxide metabolism (Pós-doutoramento)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2002/07 - 2008/12/19
Concluded
Farmácia (Doutoramento)
Major in Biochemistry
Universidade de Coimbra Faculdade de Farmácia, Portugal
"Novas vias de morte celular com implicações na doença de Parkinson envolvendo o óxido nítrico e o metabolismo da dopamina / New cell death pathways with implications for Parkinson's disease involving nitric oxide and dopamine metabolism" (THESIS/DISSERTATION)
Very good. Approved by Distinção e Louvor
2005/04/27 - 2005/04/29
Concluded
Mitochondria: between Life and Death (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2004/09/21 - 2004/10/01
Concluded
Free Radical School 2004- Free radical and Diseases: gene expression, cellular metabolism and patophysiology (Outros)
Society for Free Radical Research - Europe, France
2004/01/12 - 2004/01/16
Concluded
Biologia da Morte Celular II: Regulação da Apoptose (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2001/07 - 2003/03/25
Concluded
Biologia Celular (Mestrado)
Universidade de Coimbra Faculdade de Ciencias e Tecnologia, Portugal
"Inibição Sinergística da Respiração em Mitocôndrias de Cérebro de Rato induzida por Óxido Nítrico e Ácido 3,4-dihidroxifenilacético / " (THESIS/DISSERTATION)
Very good
2001/09/19 - 2001/09/21
Concluded
Introdução à cultura de células animais (Outros)
Universidade Nova de Lisboa Faculdade de Ciências Médicas, Portugal
2001/07/09 - 2001/07/13
Concluded
A Practical Course on Identification of Apoptosis: Mitochondrial Pathway (Outros)
Universidade de Lisboa Faculdade de Farmácia, Portugal
2001/06/18 - 2001/06/20
Concluded
Free Radicals in Biology: from Basic Science to Medicine (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2001/05/21 - 2001/05/23
Concluded
Mechanisms of Mitochondrial Toxicity (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2000/04/17 - 2000/04/21
Concluded
Electron Paramagnetic Resonance (EPR): Principles and Applications to Biology (Outros)
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1992/09 - 1998/05
Concluded
Ciências Farmacêuticas (Licenciatura)
Universidade de Coimbra Faculdade de Farmácia, Portugal
"not applicable" (THESIS/DISSERTATION)
Good (grade 15,3 out of 20)
Affiliation

Science

Category
Host institution
Employer
2021/09/22 - 2022/07/22 Contracted Researcher (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
2019/12/12 - 2021/03/31 Postdoc (Research) Universidade de Coimbra, Portugal
2009/10/01 - 2015/08/31 Postdoc (Research) Fundação para a Ciência e a Tecnologia, I.P., Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
1999/09 - 2001/06 Research Trainee (Research) Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Teaching in Higher Education

Category
Host institution
Employer
2023/03/01 - Current Assistant Professor (University Teacher) Escola Universitária Vasco da Gama, Portugal
2022/09/01 - Current Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/09/01 - 2020/08/31 Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09/01 - 2019/08/31 Invited Assistant (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/02/01 - 2018/02/28 Invited Assistant Professor (University Teacher) Universidade de Coimbra Faculdade de Farmácia, Portugal

Others

Category
Host institution
Employer
2018/04 - 2018/05 Teaching assistant Universidade de Coimbra Faculdade de Farmácia, Portugal
2011 - 2014 Teaching Assistant Universidade de Coimbra Faculdade de Farmácia, Portugal
2006/11/01 - 2009/09/30 Director of a parapharmacy Guinapo, Lda, Portugal
1998/06 - 1999/08 Pharmacist in community pharmacy Farmácia Antunes, Portugal
Projects

Grant

Designation Funders
2019/12/11 - 2021/03/31 Healthy Aging 2020
Centro 2020 000012 Healthy Aging 2020
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Ongoing
2013/04 - 2015/08/31 Red wine polyphenols as novel antimicrobial agents: molecular mechanisms involved in the protection against pathogenic intestinal bacteria
SFRH/BPD/46149/2008
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2009/10/01 - 2013/02 Prevention of inflammatory processes in gastrointestinal epithelia by dietary flavonoids via modulation of Nrf2 and nitric oxide metabolism
SFRH/BPD/46149/2008
Post-doc Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2002/07 - 2006/10 Cell death with implications for Parkinson's disease involving nitric oxide and dopamine metabolism
SFRH/BD/5428/2001
PhD Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded
2001/07 - 2002/06 Oxidative damage of brain mitochondria induced by nitric oxide and dopamine
SFRH/BM/2464/2000
Master Student Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia, I.P.
Concluded

Contract

Designation Funders
2023/03/01 - 2026/02/28 The Neurovascular Coupling as a biomarker and a target for cognitive enhancement in aging and vascular dementia through an innovative dietary nitrate-driven nitric oxide redox cycle: a translational study
2022.05454.PTDC
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/01/01 - 2025/12/31 Center for Innovative Biomedicine and Biotechnology - Associate Laboratory
LA/P/0058/2020
Post-doc
Universidade de Coimbra Centro de Inovação em Biomedicina e Biotecnologia, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2021/09/22 - 2022/07/22 Monitoring neurometabolic markers in vivo using microelectrode-based biosensors
POCI-01-0145-FEDER-028261
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2018/07/26 - 2021/07/25 Cognitive enhancement in aged brain and vascular dementia in humans through improving neurovascular coupling: a mechanism based approach driven by nitrite and ascorbic acid from diet
PTDC/MED-NEU/29099/2017
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal

Centro Hospitalar e Universitário de Coimbra EPE, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2015/01/01 - 2018/12/31 CNC. IBILI
UID/NEU/04539/2013
Post-doc
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
2012/04/01 - 2015/03/31 Nitric Oxide in Alzheimer´s Disease - Signaling Molecule and Mediator of Pathogenesis
PTDC/BIA-BCM/116576/2010
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/03/01 - 2014/12/31 Dietary Nitrate:Nitrite:Nitric oxide as a key pathway in gastrointestinal and cardiovascular physiology: uncovering new health properties of red wine and olive oil
PTDC/AGR-ALI/115744/2009
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/05/01 - 2013/10/31 Role of dietary polyphenols on intestinal inflammation either as single agents or in combination with anti-inflammatory drugs by using in vitro and in vivo models
PTDC/SAU-OSM/102907/2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2010/06/01 - 2013/06/30 In vivo dynamics of nitric oxide in the brain: regulation of cellular respiration and implications for Alzheimer´s disease and aging
PTDC/SAU-NEU/103538/2008
Researcher
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal

Universidade de Coimbra, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2011/01/01 - 2012/12/31 Strategic Project - LA 1 - 2011-2012
PEst-C/SAU/LA0001/2011
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
2001 - 2003 Real-time measurement of nitric oxide in hippocampal brain slices: modulation by tissue redox state with implications for neuronal degeneration.
POCTI/BCI/42365/2001
Research Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1999 - 2001 Mitochondrial dysfunction induced by nitric oxide and dopamine in neuronal degeneration
PRAXIS/C/BIA/13195/98
Scientific Initiation Fellow
Universidade de Coimbra Centro de Neurociências e Biologia Celular, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference abstract
  1. Barbosa, Rui M.; Lourenço, Cátia; Nunes, Carla; Manaia, Márcia; Ferreira, Nuno R.; Laranjinha, João. "Monitoring Hydrogen Peroxide in Biological Media: Electrochemical Sensing Approaches". Paper presented in SFRR-E 2019 annual meeting “Redox Homeostasis: from Signaling to Damage, Ferrara, 2019.
    Published
  2. Nunes, Carla; Freitas, Víctor; Laranjinha, João. "Modulation of tight junctions in intestinal epithelial cells by red wine polyphenols". Paper presented in 19th Biennial Meeting of the Society-for-Free-Radical-Research-International (SFRRI), 2018.
    Published • 10.1016/j.freeradbiomed.2018.04.491
  3. Ledo, Ana; Lourenço, Cátia; Nunes, Carla; Santos, Daniela; Laranjinha, João; Barbosa, Rui M.. "Electrochemical (bio)sensors for high-resolution measurements of hydrogen peroxide in biological media". Paper presented in 19th Biennal Meeting for the Society for Free Radical Research International (SFRRI),, Lisbon, 2018.
    Published • 10.1016/j.freeradbiomed.2018.04.476
  4. Nunes, Carla; Figueiredo, Rui; Card, Roderick; AbuOun, Manal; Bagnall, Mary C.; Nunez, Javier; Mendonça, Nuno; Anjum, Muna F.; da Silva, Gabriela Jorge. "Virulence, antimicrobial and heavy metal resistance characterization by a new microarray and whole genome sequencing in Salmonella enterica: is there significance for the commensal microbiome?". Paper presented in 3rd World Congress on Targeting Microbiota, Paris, 2015.
    Published
  5. Figueiredo, Rui; Card, Roderick; Nunes, Carla; AbuOun, Manal; Bagnall, Mary C.; Nunez, Javier; Mendonça, Nuno; Anjum, Muna F.; da Silva, Gabriela Jorge. "Monitoring virulence potential of Salmonella enteric from animal food products". Paper presented in EFSA's 2nd Scientific Conference. Shaping the Future of Food Safety, Together, Mião, 2015.
    Published
  6. Laranjinha, João; Rocha, Bárbara S.; Pereira, Cassilda; Nunes, Carla; Barbosa, Rui M.. "Alternative pathway to widespread health benefits of dietary polyphenols: The nitrate-nitrite-nitric oxide pathway in the gut". Paper presented in 62nd International Congress and Annual Meeting of the Society-of-Medicinal-Plant-and-Natural-Product-Research, Guimarães, 2014.
    Published • 10.1055/s-0034-1394483
  7. Laranjinha, João; Rocha, Bárbara S.; Pereira, Cassilda; Nunes, Carla; Gago, Bruno; Barbosa; Rui M.. "A short-cut to inclusive health benefits of dietary polyphenols: the nitrate:nitrite:nitric oxide pathway in the gut". Paper presented in 17 th Biennial meeting of Society for Free Radical Research International,, Kyoto, 2014.
    Published
  8. Serra, Diana; Paixão, Joana; Nunes, Carla; Almeida, Leonor M.; Dinis, Teresa C.P.. "The mechanisms behind the inhibition of cytokine-induced inflammatory response by Cyanidin 3-Glucoside and Resveratrol in human intestinal cells: comparison with 5-ASA". Paper presented in SFRR- Europe 2013 Meeting, Atenas, 2013.
    Published • 10.1016/j.freeradbiomed.2013.08.147
  9. Nunes, Carla; Freitas, Víctor; Almeida, Leonor; Barbosa, Rui M.; Laranjinha, João. "Red wine protects intestinal epithelial cells from inflammation by activating the Nrf2 pathway and reinforcing tight junctions". Paper presented in 16th biennial meeting for the Society for Free Radical Research International (SFRRI), Londres, 2012.
    Published • 10.1016/j.freeradbiomed.2012.08.409
  10. Serra, Diana; Paixão, Joana; Nunes, Carla; Almeida, Leonor; Dinis, Teresa C.P.. "Cyanidin-3-glucoside suppresses cytokine-induced inflammatory response in human intestinal cells: comparison with 5-aminosalicylic acid". Paper presented in 16th biennial meeting for the Society for Free Radical Research International (SFRRI), Londres, 2012.
    Published • 10.1016/j.freeradbiomed.2012.08.358
  11. Nunes, Carla; Almeida, Leonor; Laranjinha, João. "Mechanisms of PC-12 cell death exposed to nitric oxide and 3,4-dihydroxyphenylacetic acid". Paper presented in SFRR Europe 2007, Vilamoura, 2007.
    Published • 10.1080/10715760701615118
  12. Gago, Bruno; Nunes, Carla; Laranjinha, João. "Non-enzymatic production of nitric oxide. Reduction of nitrite to nitric oxide by caffeic acid and 3,4-dihydroxyphenylacetic acid". Paper presented in 1º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas, Lisboa, 2003.
    Published
  13. Sousa, Teresa; Fernandes, Eduarda; Carvalho, Félix; Laranjinha, João; Nunes, Carla; Albino-Teixeira, António. "Inactivaction of nitric oxide by a xanthinic hypertensive agent". 2002.
    Published • 10.1109/eit.2009.5189608
  14. Sousa, Teresa; Fernandes, Eduarda; Carvalho, Félix; Laranjinha, João; Nunes, Carla; Albino-Teixeira, António. "Direct scavenging of nitric oxide by DPSPX (1,3-dipropyl-8-sulfophenilxanthine)". Paper presented in Autumn meeting of the British Pharmacological Society & the Physiological Society with Sociedade Portuguesa de Farmacologia, Bristol, 2002.
    Published
  15. Nunes, Carla; Laranjinha, João. "Synergistic inhibition of mitochondrial respiratory function by nitric oxide and DOPAC". Paper presented in XIth Meeting of the Society for Free Radical Research International, Paris, 2002.
    Published
  16. Nunes, Carla; Laranjinha, João. "Superoxide Dismutase, Nitric Oxide and 3,4-dihydroxyphenylacetic acid cooperate to inhibit the respiratory chain of rat brain mitochondria". Paper presented in 27th FEBS meeting, Lisboa, 2001.
    Published
Conference poster
  1. Couto, Joana; Figueirinha, Artur; Batista, Maria Teresa; Paranhos, António; Nunes, Carla; Gonçalves, Lídia Maria; Marto, Joana; et al. "Development of antioxidant topical gel containing a Fragaria vesca L. extract". Paper presented in Iberphenol International Conference: Advances in the role of phenols in health effects and other uses., 2020.
  2. Nunes, Carla; Freitas, Victor; Laranjinha, João. "The molecular mechanisms underlying the intestinal anti-inflammatory activity of wine polyphenols.". Paper presented in Iberphenol International Conference: Advances in the role of phenols in health effects and other uses,, 2020.
  3. Barbosa, Rui M.; Lourenço, Cátia; Nunes, Carla; Manaia, Márcia; Ferreira, Nuno R.; Laranjinha, João; Ledo, Ana. "Monitoring Hydrogen Peroxide in Biological Media: Electrochemical Sensing Approaches". Paper presented in SFRR-E 2019 annual meeting “Redox Homeostasis: from Signaling to Damage, 2019.
  4. Nunes, Carla; Freitas, Víctor; Laranjinha, João. "Modulation of tight junctions in intestinal epithelial cells by red wine polyphenols.". Paper presented in 19th Biennal Meeting for the Society for Free Radical Research International (SFRRI), 2018.
  5. Ledo, Ana; Lourenço, Cátia; Nunes, Carla; Santos, Daniela; Laranjinha, João; Barbosa, Rui M.. "Electrochemical (bio)sensors for high-resolution measurements of hydrogen peroxide in biological media.". Paper presented in 19th Biennal Meeting for the Society for Free Radical Research International (SFRRI), 2018.
  6. Nunes, Carla; Figueiredo, Rui; Freitas, Víctor; Barbosa, Rui M.; Laranjinha, J.; da Silva, Gabriela Jorge. "Human Intestinal Epithelial Cells Are Protected from Pathogenic Escherichia coli by Red Wine Extract". Paper presented in 11th International Scientific Conference on Probiotics and Prebiotics – IPC2017,, 2017.
  7. Figueiredo, Rui; Card, Roderick; Nunes, Carla; AbuOun, Manal; Bagnall, Mary C.; Nunez, Javier; Mendonça, Nuno; Anjum, Muna F.; da Silva, Gabriela Jorge. "Virulence, antimicrobial and heavy metal resistance characterization by a new microarray and whole genome sequencing in Salmonella enterica: is there significance for the commensal microbiome?". Paper presented in 3rd World Congress on Targeting Microbiota. International Society of Microbiota., 2015.
  8. Nunes, Carla; Figueiredo, Rui; Card, Roderick; AbuOun, Manal; Bagnall, Mary C.; Nunez, Javier; Mendonça, Nuno; Anjum, Muna F.; da Silva, Gabriela Jorge. "Monitoring virulence potential of Salmonella enterica from animal food products". Paper presented in EFSA's 2nd Scientific Conference. Shaping the Future of Food Safety, Together., 2015.
  9. Figueiredo, Rui; Card, Roderick; Nunes, Carla; AbuOun, Manal; Bagnall, Mary C.; Nunez, Javier; Mendonça, Nuno; Anjum, Muna F.; da Silva, Gabriela Jorge. "Detection and functionality of Cytolethal Distending Toxin in Salmonella entérica serotype Typhimurium". Paper presented in Society for General Microbiology Irish Division Meeting: Microbial Interfaces., 2015.
  10. Nunes, Carla; Figueiredo, Rui; Freitas, Víctor; Barbosa, R.M.; da Silva, Gabriela Jorge; Laranjinha, João. "A Red Wine Extract protects intestinal epithelial cells against pathogenic bacteria". Paper presented in XVIII Congress of the Portuguese Biochemical Society., 2014.
  11. Nunes, Carla; Freitas, Víctor; Barbosa, Rui M.; Almeida, Leonor; Laranjinha, João. "A Red Wine Extract protects intestinal epithelial cells from inflammation via modulation of JAK/STAT and Nrf2 pathways". Paper presented in XVIII Congress of the Portuguese Biochemical Society, 2014.
  12. Figueiredo, Rui; Card, Roderick; Nunes, Carla; AbuOun, Manal; Bagnall, Mary C.; Mendonça, Nuno; Anjum, Muna F.; da Silva, Gabriela Jorge. "Microarrays Analysis of Antimicrobial Resistance and Virulence Genes of Salmonella enterica from food producing Animals: a non-invasive S. Infantis associated with Uncommon Pathogenicity Island 1". Paper presented in 24th ESCMID, 2014.
  13. Laranjinha, João; Rocha, Bárbara; Pereira, Cassilda; Nunes, Carla; Gago, Bruno; Barbosa, Rui M.. "A short-cut to inclusive health benefits of dietary polyphenols: the nitrate:nitrite:nitric oxide pathway in the gut". Paper presented in 17 th Biennial meeting of Society for Free Radical Research International, 2014.
  14. Figueiredo, Rui; Card, Roderick; Nunes, Carla; AbuOun, Manal; Bagnall, Mary C.; Nunez, Javier; Mendonça, Nuno; Anjum, Muna F.; da Silva, Gabriela Jorge. "Microarray analysis of virulence and antimicrobial resistance genes in Salmonella entérica from animals and retail meat: Unusual pathogenicity island in a serovar". Paper presented in XI Reunião Anual do CNC, 2013.
  15. Serra, Diana; Paixão, Joana; Nunes, Carla; Almeida, Leonor; Dinis, Teresa C.P.. "Cyanidin-3-glucoside inhibits pro-inflammatory mediators expression in human intestinal cells by down-regulating STAT1 activation: a comparative study with 5-aminosalicylic acid". Paper presented in VI International Conference on Polyphenols and Health (ICPH 2013),, 2013.
  16. Nunes, Carla; Freitas, Víctor; Barbosa, Rui M.; Almeida, Leonor; Laranjinha, João. "Molecular mechanisms underlying the intestinal anti-inflammatory activity of a red wine polyphenolic extract in colonic epithelial cells". Paper presented in 7th International workshop on anthocyanins, 2013.
  17. Serra, Diana; Paixão, Joana; Nunes, Carla; Almeida, Leonor; Dinis, Teresa C.P.. "Study of the potential anti-inflammatory properties of cyanidin 3-glucoside on the inhibition of cytokine-induced inflammatory response in human intestinal cells". Paper presented in 7th International workshop on anthocyanins, 2013.
  18. Serra, Diana; Paixão, Joana; Nunes, Carla; Almeida, Leonor M.; Dinis, Teresa C.P.. "A comparative study of cyaniding-3-glucoside and 5-ASA as suppressors of Cytokine-induced inflammatory response in human intestinal cells". Paper presented in X Encontro Anual do CNC, 2012.
  19. Nunes, Carla; Ferreira, Elisabete; Freitas, Víctor; Barbosa, Rui M.; Laranjinha, João. "Red wine protects intestinal epithelial cells from inflammation by activating the Nrf2 pathway and reinforcing tight junctions". Paper presented in 16th biennial meeting for the Society for Free Radical Research International (SFRRI), 2012.
  20. Serra, Diana; Paixão, Joana; Nunes, Carla; Almeida, Leonor; Dinis, Teresa C.P.. "Cyanidin-3-glucoside suppresses cytokine-induced inflammatory response in human intestinal cells: comparison with 5-aminosalicylic acid". Paper presented in 16th biennial meeting for the Society for Free Radical Research International (SFRRI), 2012.
  21. Nunes, Carla; Ferreira, Elisabete; Freitas, Víctor; Barbosa, Rui M.; Laranjinha, João. "The intestinal anti-inflammatory activity of a red wine extract is related with both, inhibition of iNOS expression and activation of Nrf-2 pathway". Paper presented in 5th International Conference on Polyphenols and Health, 2011.
  22. Nunes, Carla; Ferreira, Elisabete; Freitas, Víctor; Barbosa, Rui M.; Almeida, Leonor; Laranjinha, João. "The intestinal anti-inflammatory action of red wine extracts in the colonic epithelial cells is associated with an inhibition of iNOS expression". Paper presented in XVII Congresso Nacional de Bioquímica, 2010.
  23. Nunes, Carla; Barbosa, Rui M.; Laranjinha, João. "Luteolin inhibits TNF-alpha- induced inflammation in Human colon epithelial cells". Paper presented in International Symposium on the Pathophysiology of Reactive Oxygen and Nitrogen Species and the IV Luso-Spanish meeting on Free Radicals, 2010.
  24. Nunes, Carla; Almeida, Leonor; Laranjinha, João. "Mechanisms of PC-12 cell death exposed to nitric oxide and 3,4-dihydroxyphenylacetic acid". Paper presented in SFRR Europe 2007, 2007.
  25. Nunes, Carla; Laranjinha, João. "Superoxide Dismutase, Nitric Oxide and 3,4-dihydroxyphenylacetic acid cooperate to inhibit the respiratory chain of rat brain mitochondria". Paper presented in 27th FEBS meeting, 2006.
  26. Nunes, Carla; Almeida, Leonor; Laranjinha, João. "Cell death in PC-12 cells induced by 3,4-dihydroxyphenylacetic acid and nitric oxide. The critical role of glutathione". Paper presented in Oxidants and Antioxidants in Biology, 2005.
  27. Nunes, Carla; Almeida, Leonor; Laranjinha, João. "3,4-dihydroxyphenylacetic acid modulates the toxicity induced by nitric oxide in PC-12 cells. The critical role of GSH". Paper presented in 2nd Spanish and Portuguese Congress on Free Radicals, 2004.
  28. Nunes, Carla; Almeida, Leonor; Laranjinha, João. "Vulnerability of PC-12 cells exposed to nitric oxide and DOPAC. Effect of caffeic acid". Paper presented in 1st Luso-Spanish Congress on Free Radicals/ 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine, 2003.
  29. Gago, Bruno; Nunes, Carla; Antunes, Fernando; Laranjinha, João. "“Reduction of nitrite to nitric oxide by caffeic acid, dopamine and 3,4-dihydroxyphenylacetic acid". Paper presented in 1st Luso-Spanish Congress on Free Radicals/ 6th Portuguese Congress on Free Radicals in Chemistry, Biology and Medicine, 2003.
  30. Gago, Bruno; Nunes, Carla; Laranjinha, João. "Non-enzymatic production of nitric oxide. Reduction of nitrite to nitric oxide by caffeic acid and 3,4-dihydroxyphenylacetic acid". Paper presented in 1º Congresso da Sociedade Portuguesa de Ciências Farmacêuticas, 2003.
  31. Nunes, Carla; Laranjinha, João. "Nitric oxide-dependent inhibition of mitochondrial respiration and ATP synthesis is enhanced by its interaction with DOPAC". Paper presented in XIII Congresso Nacional de Bioquímica, 2002.
  32. Nunes, Carla; Laranjinha, João. "Efeito combinado do óxido nítrico e do DOPAC no consumo de O2 e na síntese de ATP em mitocôndrias de cérebro de rato". Paper presented in VII Reunión del Grupo Español de Radicales Libres y III Reunión Iberoamericana, 2002.
  33. Nunes, Carla; Laranjinha, João. "Mechanisms of brain mitochondrial dysfunction involving nitric oxide and dihydroxyphenylacetic acid". Paper presented in 5º Congresso de Radicais Livres em Química, Biologia e Medicina, 2001.
  34. Nunes, Carla; Laranjinha, João. "Mechanism of the nitric oxide and 3,4-Dihydroxyphenylacetic acid synergistic inhibition of respiratory chain of rat brain mitochondria". Paper presented in 7ª reunião da Sociedade Portuguesa de Neurociências, 2001.
  35. Nunes, Carla; Sousa, Teresa; Fernandes, Eduarda; Carvalho, Félix; Laranjinha, João; Albino-Teixeira, António. "Direct scavenging of nitric oxide by DPSPX (1,3-dipropyl-8-sulfophenilxantine)". Paper presented in Autumn meeting of the British Pharmacological Society & the Physiological Society with Sociedade Portuguesa de Farmacologia, 2001.
  36. Nunes, Carla; Laranjinha, João. "Nitric Oxide and dihydroxyphenylacetic acid interact to inhibit the respiratory Chain of Brain Mitochondria". Paper presented in IInd International Meeting on Oxidative: Biochemistry and Pathophysiology. Winter Meeting of the Society for Free Radical Research-Europe, 2000.
  37. Nunes, Carla; Laranjinha, João. "Respiratory Chain of Brain Mitochondria is inhibited by concerted activity of Nitric Oxide and DOPAC". Paper presented in II Congresso de Investigação em Medicina, 2000.
  38. Nunes, Carla; Laranjinha, João. "Concerted activity of nitric oxide and DOPAC in the inhibition of respiratory chain of brain mitochondria". Paper presented in XII Congresso Nacional de Bioquímica, 2000.
Journal article
  1. Carla Nunes; João Laranjinha. "Nitric Oxide Production from Nitrite plus Ascorbate during Ischemia upon Hippocampal Glutamate NMDA Receptor Stimulation". BioChem (2023): https://doi.org/10.3390/biochem3020006.
    10.3390/biochem3020006
  2. Carla Nunes; João Laranjinha. "Nitric oxide and dopamine metabolism converge via mitochondrial dysfunction in the mechanisms of neurodegeneration in Parkinson's disease". Archives of Biochemistry and Biophysics 704 (2021): 108877-108877. https://doi.org/10.1016/j.abb.2021.108877.
    10.1016/j.abb.2021.108877
  3. Laranjinha, João; Nunes, Carla; Ledo, Ana; Lourenço, Cátia; Rocha, Bárbara; Barbosa, Rui M.. "The Peculiar Facets of Nitric Oxide as a Cellular Messenger: From Disease-Associated Signaling to the Regulation of Brain Bioenergetics and Neurovascular Coupling". Neurochemical Research 46 1 (2021): 64-76. http://dx.doi.org/10.1007/s11064-020-03015-0.
    Published • 10.1007/s11064-020-03015-0
  4. Couto, Joana; Figueirinha, Artur; Batista, Maria Teresa; Paranhos, António; Nunes, Carla; Gonçalves, Lídia Maria; Marto, Joana; et al. "Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Properties". Antioxidants 9 2 (2020): 154. http://dx.doi.org/10.3390/antiox9020154.
    Published • 10.3390/antiox9020154
  5. Nunes, Carla; Figueiredo, Rui; Laranjinha, João; da Silva, Gabriela Jorge. "Intestinal cytotoxicity induced by Escherichia coli is fully prevented by red wine polyphenol extract: Mechanistic insights in epithelial cells". Chemico-Biological Interactions 310 (2019): 108711. http://dx.doi.org/10.1016/j.cbi.2019.06.024.
    Published • 10.1016/j.cbi.2019.06.024
  6. Carla Nunes; Víctor Freitas; Leonor Almeida; João Laranjinha. "Red wine extract preserves tight junctions in intestinal epithelial cells under inflammatory conditions: implications for intestinal inflammation". Food & Function (2019): https://doi.org/10.1039/C8FO02469C.
    10.1039/C8FO02469C
  7. Nunes, Carla; Almeida, Leonor; Barbosa, Rui M.; Laranjinha, João. "Luteolin suppresses the JAK/STAT pathway in a cellular model of intestinal inflammation". Food & Function 8 1 (2017): 387-396. http://dx.doi.org/10.1039/c6fo01529h.
    Published • 10.1039/c6fo01529h
  8. Nunes, Carla; Rocha, Bárbara S.; Laranjinha, João. "Tuning constitutive and pathological inflammation in the gut via the interaction of dietary nitrate and polyphenols with host microbiome". The International Journal of Biochemistry & Cell Biology 81 (2016): 393-402. http://dx.doi.org/10.1016/j.biocel.2016.10.021.
    Published • 10.1016/j.biocel.2016.10.021
  9. Nunes, Carla; Teixeira, N.; Serra, D.; Freitas, V.; Almeida, L.; Laranjinha, João. "Red wine polyphenol extract efficiently protects intestinal epithelial cells from inflammation via opposite modulation of JAK/STAT and Nrf2 pathways". Toxicology Research 5 1 (2016): 53-65. http://dx.doi.org/10.1039/c5tx00214a.
    Published • 10.1039/c5tx00214a
  10. Figueiredo, Rui; Card, Roderick; Nunes, Carla; AbuOun, Manal; Bagnall, Mary C.; Nunez, Javier; Mendonça, Nuno; Anjum, Muna F.; da Silva, Gabriela Jorge. "Virulence Characterization of Salmonella enterica by a New Microarray: Detection and Evaluation of the Cytolethal Distending Toxin Gene Activity in the Unusual Host S. Typhimurium". PLOS ONE 10 8 (2015): e0135010. http://dx.doi.org/10.1371/journal.pone.0135010.
    Published • 10.1371/journal.pone.0135010
  11. Silva, Ana; Nunes, Carla; Martins, João; Dinis, Teresa C.P.; Lopes, Celeste; Neves, Bruno; Cruz, Teresa. "Respiratory sensitizer hexamethylene diisocyanate inhibits SOD 1 and induces ERK-dependent detoxifying and maturation pathways in dendritic-like cells". Free Radical Biology and Medicine 72 (2014): 238-246. http://dx.doi.org/10.1016/j.freeradbiomed.2014.04.005.
    Published • 10.1016/j.freeradbiomed.2014.04.005
  12. Rocha, Bárbara S.; Nunes, Carla; Pereira, Cassilda; Barbosa, Rui M.; Laranjinha, João. "A shortcut to wide-ranging biological actions of dietary polyphenols: modulation of the nitrate–nitrite–nitric oxide pathway in the gut". Food Funct. 5 8 (2014): 1646-1652. http://dx.doi.org/10.1039/c4fo00124a.
    Published • 10.1039/c4fo00124a
  13. Oliveira, Carlos; Santarino, Inês; Enache, Teodore; Nunes, Carla; Laranjinha, João; Barbosa, R.M.; Oliveira-Brett, Ana Maria. "Human colon adenocarcinoma HT-29 cell: Electrochemistry and nicotine stimulation". Bioelectrochemistry 94 (2013): 30-38. http://dx.doi.org/10.1016/j.bioelechem.2013.05.004.
    Published • 10.1016/j.bioelechem.2013.05.004
  14. Serra, Diana; Paixão, Joana; Nunes, Carla; Dinis, Teresa C. P.; Almeida, Leonor M.. "Cyanidin-3-Glucoside Suppresses Cytokine-Induced Inflammatory Response in Human Intestinal Cells: Comparison with 5-Aminosalicylic Acid". PLoS ONE 8 9 (2013): e73001. http://dx.doi.org/10.1371/journal.pone.0073001.
    Published • 10.1371/journal.pone.0073001
  15. Nunes, Carla; Ferreira, Elisabete; Freitas, Víctor; Almeida, Leonor; Barbosa, Rui M.; Laranjinha, João. "Intestinal anti-inflammatory activity of red wine extract: unveiling the mechanisms in colonic epithelial cells". Food Funct. 4 3 (2013): 373-383. http://dx.doi.org/10.1039/c2fo30233k.
    Published • 10.1039/c2fo30233k
  16. Nunes, Carla; Barbosa, Rui M.; Almeida, Leonor; Laranjinha, João. "Nitric oxide and DOPAC-induced cell death: From GSH depletion to mitochondrial energy crisis". Molecular and Cellular Neuroscience 48 1 (2011): 94-103. http://dx.doi.org/10.1016/j.mcn.2011.06.009.
    Published • 10.1016/j.mcn.2011.06.009
  17. Nunes, Carla; Almeida, Leonor; Laranjinha, João. "3,4-Dihydroxyphenylacetic acid (DOPAC) modulates the toxicity induced by nitric oxide in PC-12 cells via mitochondrial dysfunctioning". NeuroToxicology 29 6 (2008): 998-1007. http://dx.doi.org/10.1016/j.neuro.2008.07.003.
    Published • 10.1016/j.neuro.2008.07.003
  18. Nunes, Carla; Almeida, Leonor M.; Laranjinha, João. "Synergistic inhibition of respiration in brain mitochondria by nitric oxide and dihydroxyphenylacetic acid (DOPAC)Implications for Parkinson's disease". Neurochemistry International 47 3 (2005): 173-182. http://dx.doi.org/10.1016/j.neuint.2005.03.005.
    Published • 10.1016/j.neuint.2005.03.005
  19. Antunes, Fernando; Nunes, Carla; Laranjinha, João; Cadenas, Enrique. "Redox interactions of nitric oxide with dopamine and its derivatives". Toxicology 208 2 (2005): 207-212. http://dx.doi.org/10.1016/j.tox.2004.11.033.
    Published • 10.1016/j.tox.2004.11.033
  20. Sousa, Teresa; Fernandes, Eduarda; Nunes, Carla; Laranjinha, João; Carvalho, Félix; Pinho, Dora; Morato, Manuela; Albino-Teixeira, António. "Scavenging of nitric oxide by an antagonist of adenosine receptors". Journal of Pharmacy and Pharmacology 57 3 (2005): 399-404. http://dx.doi.org/10.1211/0022357055614.
    Published • 10.1211/0022357055614
Magazine article
  1. Nunes, Carla. "O Colesterol e as Doenças Cardiovasculares / Cholesterol and Cardiovascular Diseases", Com Olhos de Ver, 2020
  2. Nunes, Carla. "Acidente Vascular Cerebral / Stroke", Com olhos de ver, 2016
Thesis / Dissertation
  1. Nunes, Carla. "Novas vias de morte celular com implicações na doença de Parkinson envolvendo o óxido nítrico e o metabolismo da dopamina /New cell death pathways with implications for Parkinson's disease involving nitric oxide and dopamine metabolism". PhD, Universidade de Coimbra Faculdade de Farmácia, 2008. http://hdl.handle.net/10316/9658.
  2. Nunes, Carla. "Inibição Sinergística da Respiração em Mitocôndrias de Cérebro de Rato induzida por Óxido Nítrico e Ácido 3,4-dihidroxifenilacético /Synergistic Inhibition of Breathing in Mitochondria of Mouse Brain induced by Nitric Oxide and 3,4-dihydroxyphenylacetic acid". Master, Universidade de Coimbra Faculdade de Ciencias e Tecnologia, 2003.
Activities

Jury of academic degree

Topic
Role
Candidate name (Type of degree)
Institution / Organization
2019/09 Physiological Disorders Induced by Nonsteroidal Anti-Inflammatory Drugs: The Problem of Banalizing Access to Medicines.
(Thesis) Main arguer
Patrícia Carneiro Teixeira Vilela (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2019/07 Coenzima Q10: da suplementação à terapêutica em insuficiência cardíaca / Coenzyme Q10: from supplementation to therapy in heart failure
(Thesis) Main arguer
João Paulo Mendes Delgado (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018/09 O uso da Cannabis e o desenvolvimento da psicose / The use of cannabis and the development of psychosis
(Thesis) Main arguer
Inês Margarida De Almeida Cruz (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2018 A influência do alelo épsilon 4 do gene da apolipoproteína E no risco de desenvolvimento da doença de Alzheimer / The influence of the epsilon 4 allele of the apolipoprotein E gene on the risk of developing Alzheimer's disease
(Thesis) Main arguer
Beatriz Dias Ferreira (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/10 Glioblastoma Multiforme: Biomarcadores e Perspetiva Atual e Futura da Terapêutica / Glioblastoma Multiforme: Biomarkers and Current and Future Perspective of Therapeutics
(Thesis) Main arguer
Nelson Emanuel De Carvalho Fortuna (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2017/03 Impacto da creatina no desempenho do atleta / Impact of creatine on athlete performance
(Thesis) Main arguer
Nuno Constantino Pereira Reboredo Mateus Marques (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/09 Nutrigenómica e qualidade de vida: funções e eficácia de moduladores de Nrf2 presentes em suplementos da dieta / Nutrigenomics and quality of life: functions and efficacy of Nrf2 modulators present in dietary supplements
(Thesis) Main arguer
Luís Francisco Vaz (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/07 Psoríase: abordagem terapêutica e perspetivas futuras / Psoriasis: therapeutic approach and future perspectives
(Thesis) Main arguer
Teresa Nunes de Moura Pinheiro de Magalhães (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2016/07 Síndrome metabólico e dieta vegetariana: relação benéfica, deletéria ou irrelevante? / Metabolic syndrome and vegetarian diet: beneficial, harmful or irrelevant relationship?
(Thesis) Main arguer
Pedro de Azevedo Lijnzaat (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/09 Ação de Flavonóides na Doença Inflamatória Intestinal / Action of Flavonoids in Inflammatory Bowel Disease
(Thesis) Main arguer
Luy Jin (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/09 Fatores de Risco no Acidente Vascular Cerebral / Risk Factors in Stroke
(Thesis) Main arguer
Paula Cristina Rodrigues Cubeiro (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal
2015/03/27 Preparação e avaliação da atividade antimicrobiana de triterpenóides semi-sintéticos / Preparation and evaluation of antimicrobial activity of semi-synthetic triterpenoids
(Thesis) Main arguer
Manuela Santos Pereira (Master)
Universidade de Coimbra Faculdade de Farmácia, Portugal