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Helder Pinheiro. Concluiu o(a) Mestrado integrado em Medicina em 2014/06 pelo(a) Universidade do Porto Faculdade de Medicina, Doutoramento em Farmacologia em 2004/05/07 pelo(a) Universidade do Porto Faculdade de Farmácia, Doutoramento em Ciências Farmacêuticas em 2004 pelo(a) Universidade do Porto Faculdade de Farmácia, Mestrado em Mestrado Integrado em Medicina em 2014/06 pelo(a) Universidade do Porto Faculdade de Medicina e Licenciatura em Ciências Farmacêuticas em 1997 pelo(a) Universidade do Porto Faculdade de Farmácia. Publicou 16 artigos em revistas especializadas. Recebeu 3 prémio(s) e/ou homenagens. Atua na(s) área(s) de Ciências Médicas e da Saúde com ênfase em Ciências da Saúde com ênfase em Doenças Infeciosas. No seu currículo Ciência Vitae os termos mais frequentes na contextualização da produção científica, tecnológica e artístico-cultural são: Biosensor; Fibra óptica; Catecolaminas; Enzima; Antihypertensive; Angiotensin-converting enzyme; Bioactive peptides; Hypertension; Mechanisms of action; Whey; Science & Technology; Medicina básica; Basic medicine; Ciências médicas e da saúde::Medicina básica; Medical and Health sciences::Basic medicine; Gastrointestinal discomfort; Gut microbiota; Bread Wheat germ; Randomised controlled trial; Bread; Wheat germ; Medicine(all); Brewer yeast; Functional ingredients; Salt substitute; Ultrafiltration system; Brewery byproducts; Spent brewer's yeast; Response surface methodology; ACE inhibitory peptides; Domínio/Área Científica::Engenharia e Tecnologia::Outras Engenharias e Tecnologias; .
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Identification

Personal identification

Full name
Helder Pinheiro

Citation names

  • Pinheiro, Helder

Author identifiers

Ciência ID
FA13-B4AD-4BBB
ORCID iD
0000-0001-6076-2670

Knowledge fields

  • Medical and Health Sciences - Health Sciences - Infectious Diseases
  • Medical and Health Sciences - Basic Medicine - Pharmacology and pharmacy

Languages

Language Speaking Reading Writing Listening Peer-review
English Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2) Upper intermediate (B2)
Education
Degree Classification
2016/01/01 - 2021/04/21
Concluded
 Doenças Infeciosas (Título de especialista)
Major in Doenças Infeciosas
Centro Hospitalar de Lisboa Central EPE, Portugal
 18,97
2014/06
Concluded
 Mestrado Integrado em Medicina (Mestrado)
Universidade do Porto Faculdade de Medicina, Portugal
"n/a" (THESIS/DISSERTATION)
 16
2004/05/07
Concluded
 Farmacologia (Doutoramento)
Major in Sem especialidade
Universidade do Porto Faculdade de Farmácia, Portugal
"Caracterização Farmacológica do Receptor Pré-juncional Simpático da Angiotensina II" (THESIS/DISSERTATION)
 Aprovado por unanimidade
1997
Concluded
 Ciências Farmacêuticas (Licenciatura)
Universidade do Porto Faculdade de Farmácia, Portugal
"Licenciatura" (THESIS/DISSERTATION)
 Fiftheen Values
Affiliation

Teaching in Higher Education

Category
Host institution 		Employer
2017/03 - Current Invited Assistant Professor (University Teacher) Universidade Nova de Lisboa, Portugal
2013 - 2016/08 Adjunct Teacher (Polytechnic Teacher) Escola Superior de Enfermagem do Porto, Portugal
2013 - 2016 Adjunct Teacher (Polytechnic Teacher) Escola Superior de Enfermagem do Porto, Portugal
2007/07/06 - 2012/07/05 Assistant Professor (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
2004/07/29 - 2007/07/06 Assistant (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal
2002/05/03 - 2004/07/28 Trainee Assistant (University Teacher) Universidade do Porto Faculdade de Farmácia, Portugal

Others

Category
Host institution 		Employer
2016/01/01 - Current Médico - Doenças Infeciosas Centro Hospitalar de Lisboa Central EPE, Portugal
Hospital Curry Cabral, Portugal
Projects

Contract

Designation Funders
2008/01/01 - 2011/05/31 Desenvolvimento de um novo biosensor de fibra óptica para determinação de catecolaminas CATSENSOR
PTDC/QUI/70970/2006
Universidade do Porto Faculdade de Medicina, Portugal

Universidade de Aveiro, Portugal

Universidade Católica Portuguesa, Portugal
Fundação para a Ciência e a Tecnologia
Concluded
1998/07/01 - 2002/06/30 ACÇÃO PREJUNCIONAL DA BRADICININA EXERCIDA AO NÍVEL DOS NEURÓNIOS SIMPÁTICOS
PRAXIS XXI/BD/15708/98
Universidade do Porto Faculdade de Ciências, Portugal
 Fundação para a Ciência e a Tecnologia
Concluded
Outputs

Publications

Conference paper
  1. Amorim, Manuela; Pereira, Joana; Pinheiro, Hélder; Pacheco, Maria Teresa; Pintado, Manuela. "Formulation and consumer acceptance of cereal bars with functional properties by the incorporation of peptides and ß- glucans from Spent Brewer's Yeast". 2014.
  2. Amorim, Manuela; Pereira, Joana; Monteiro, Karin; Ruiz, Ana; Pinheiro, Hélder; Carvalho, João; Pintado, Manuela. "Antiulcerative and antitumoral properties of spent brewer's yeast peptide extracts for incorporation in foods". 2014.
  3. Silva, L.I.B.; Pereira, M.E.; Duarte, A.C.; Gomes, A.M.; Pintado, M.M.; Pinheiro, H.; Moura, D.; Freitas, A.C.; Rocha-Santos, T.A.P.. "Significance of fast and simple determination of catecholamines and their metabolites in patients with Down syndrome". 2011.
Journal article
  1. Caria, João; Pinto, Raquel; Leal, Ema; Almeida, Vasco; Cristóvão, Gonçalo; Gonçalves, Ana Catarina; Torres, Margarida; et al. "Clinical and epidemiological features of hospitalized and ambulatory patients with human monkeypox infection: a retrospective observational study in Portugal". (2022): http://hdl.handle.net/10451/55194.
    10.3390/idr14060083
  2. Moreira-Rosário, André; Marques, Cláudia; Pinheiro, Hélder; Araújo, João Ricardo; Ribeiro, Pedro; Rocha, Rita; Mota, Inês; et al. "Gut Microbiota Diversity and C-Reactive Protein Are Predictors of Disease Severity in COVID-19 Patients". (2021): http://hdl.handle.net/10362/125087.
    https://doi.org/10.3389/fmicb.2021.705020
  3. Moreira-Rosário, André; Marques, Cláudia; Pinheiro, Helder; Norberto, Sónia; Sintra, Diana; Teixeira, J. A.; Calhau, Conceição; et al. "Daily intake of wheat germ-enriched bread may promote a healthy gut bacterial microbiota: a randomised controlled trial". European Journal of Nutrition (2020): http://hdl.handle.net/1822/65965.
    10.1007/s00394-019-02045-x
  4. Moreira-Rosário, André; Pinheiro, Helder; Marques, Cláudia; Teixeira, J. A.; Calhau, Conceição; Azevedo, Luís Filipe; Moreira-Rosário, André; et al. "Does intake of bread supplemented with wheat germ have a preventive role on cardiovascular disease risk markers in healthy volunteers? A randomised, controlled, crossover trial". (2019): http://hdl.handle.net/1822/64320.
    10.1136/bmjopen-2018-023662
  5. Amorim, Manuela; Pinheiro, Hélder; Pintado, Manuela. "Valorization of spent brewer's yeast: optimization of hydrolysis process towards the generation of stable ACE-inhibitory peptides". (2019): http://hdl.handle.net/10400.14/27634.
    10.1016/j.lwt.2019.05.011
  6. Amorim, M.M.; Pereira, J.O.; Monteiro, K.M.; Ruiz, A.L.; Carvalho, J.E.; Pinheiro, H.; Pintado, M.; et al. "Antiulcer and antiproliferative properties of spent brewer's yeast peptide extracts for incorporation into foods". Food and Function 7 5 (2016): 2331-2337. http://www.scopus.com/inward/record.url?eid=2-s2.0-84971353865&partnerID=MN8TOARS.
    10.1039/c6fo00030d
  7. Moreira-Rosário, A.; Pinheiro, H.; Calhau, C.; Azevedo, L.F.. "Can wheat germ have a beneficial effect on human health? A study protocol for a randomised crossover controlled trial to evaluate its health effects". BMJ Open 6 11 (2016): http://www.scopus.com/inward/record.url?eid=2-s2.0-84995475825&partnerID=MN8TOARS.
    10.1136/bmjopen-2016-013098
  8. Amorim, Manuela; Pereira, Joana O.; Gomes, David; Pereira, Carlos Dias; Pinheiro, Hélder; Pintado, M. E.; Amorim, M.; et al. "Nutritional ingredients from spent brewer's yeast obtained by hydrolysis and selective membrane filtration integrated in a pilot process". Journal of Food Engineering 185 (2016): 42-47. http://hdl.handle.net/10400.14/23060.
    10.1016/j.jfoodeng.2016.03.032
  9. Marques, C.; Amorim, M.M.; Pereira, J.O.; Guardão, L.; Martins, M.J.; Pintado, M.E.; Moura, D.; et al. "In vitro ACE-inhibitory peptide KGYGGVSLPEW facilitates noradrenaline release from sympathetic nerve terminals: Relationship with the lack of antihypertensive effect on spontaneous hypertensive rats". Peptides 71 (2015): 72-76. http://www.scopus.com/inward/record.url?eid=2-s2.0-84937239479&partnerID=MN8TOARS.
    10.1016/j.peptides.2015.06.005
  10. Silva, L.I.B.; Gomes, A.M.; Pintado, M.M.; Pinheiro, H.; Moura, D.; Freitas, A.C.; Rocha-Santos, T.A.P.; Pereira, M.E.; Duarte, A.C.. "Optical fiber bioanalyzer based on enzymatic coating matrix for catecholamines and their metabolites assessment in patients with down syndrome". IEEE Sensors Journal 12 1 (2012): 76-84. http://www.scopus.com/inward/record.url?eid=2-s2.0-82555189391&partnerID=MN8TOARS.
    10.1109/JSEN.2011.2127471
  11. Marques, C.; Amorim, M.M.; Pereira, J.O.; Pintado, M.E.; Moura, D.; Calhau, C.; Pinheiro, H.. "Bioactive peptides - are there more antihypertensive mechanisms beyond ace inhibition?". Current Pharmaceutical Design 18 30 (2012): 4706-4713. http://www.scopus.com/inward/record.url?eid=2-s2.0-84866414933&partnerID=MN8TOARS.
    10.2174/138161212802651670
  12. Carlos Talaia; Gloria Queiroz; Helder Pinheiro; Daniel Moura; Jorge Goncalves; Talaia, C.; Queiroz, G.; et al. "Involvement of G-protein beta gamma subunits on the influence of inhibitory alpha(2)-autoreceptors on the angiotensin AT(1)-receptor modulation of noradrenaline release in the rat vas deferens". Neurochemistry International 49 7 (2006): 698-707. https://hdl.handle.net/10216/96534.
    10.1016/j.neuint.2006.07.002
  13. Guimarães, S.; Pinheiro, H.. "Functional evidence that in the cardiovascular system AT1angiotensin II receptors are AT1Bprejunctionally and AT1Apostjunctionally". Cardiovascular Research 67 2 (2005): 208-215. http://www.scopus.com/inward/record.url?eid=2-s2.0-21744461722&partnerID=MN8TOARS.
    10.1016/j.cardiores.2005.04.015
  14. Guimarães, S.; Carneiro, C.; Brandão, F.; Pinheiro, H.; Albino-Teixeira, A.; Moura, D.. "A pharmacological differentiation between postjunctional (AT1A) and prejunctional (AT1B) angiotensin II receptors in the rabbit aorta". Naunyn-Schmiedeberg's Archives of Pharmacology 370 4 (2004): 262-269. http://www.scopus.com/inward/record.url?eid=2-s2.0-11244303467&partnerID=MN8TOARS.
    10.1007/s00210-004-0977-7
  15. Pinheiro, H.; Moura, D.; Albino-Teixeira, A.; Alves, C.; Torres, L.; Guimarães, S.. "A comparison of AT1angiotensin II antagonists at pre- and postjunctional angiotensin II receptors of the rat tail artery". Naunyn-Schmiedeberg's Archives of Pharmacology 366 6 (2002): 537-542. http://www.scopus.com/inward/record.url?eid=2-s2.0-0036443683&partnerID=MN8TOARS.
    10.1007/s00210-002-0645-8
  16. Guimarães, S.; Pinheiro, H.; Tavares, P.; Loio, A.; Moura, D.. "Differential effects of eprosartan and losartan at prejunctional angiotensin II receptors". Naunyn-Schmiedeberg's Archives of Pharmacology 363 5 (2001): 509-514. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035004930&partnerID=MN8TOARS.
    10.1007/s002100100396
  17. Calhau, C.; Martel, F.; Pinheiro-Silva, S.; Pinheiro, H.; Soares-da-Silva, P.; Hipólito-Reis, C.; Azevedo, I.. "Modulation of insulin transport in rat brain microvessel endothelial cells by an ecto-phosphatase activity". Journal of Cellular Biochemistry 84 2 (2001): 389-400. http://www.scopus.com/inward/record.url?eid=2-s2.0-0035678474&partnerID=MN8TOARS.
    10.1002/jcb.10027
  18. Moura, D.; Pinheiro, H.; Paiva, M.Q.; Guimarães, S.. "Prejunctional effects of angiotensin II and bradykinin in the heart and blood vessels". Journal of Autonomic Pharmacology 19 6 (1999): 321-325. http://www.scopus.com/inward/record.url?eid=2-s2.0-0033306179&partnerID=MN8TOARS.
    10.1111/j.1365-2680.1999.tb00004.x
Thesis / Dissertation
  1. Amorim, Maria Manuela Faria. "Development and characterization of functional ingredients through valorization of spent brewer yeast : peptide concentrates and ß-glucans with biological activities". PhD, 2018. http://hdl.handle.net/10400.14/27700.
  2. Hélder José Marques Pinheiro. "Distinct biological activity of different in vitro angiotensin-converting enzyme inhibitors from whey and brewer's yeast". Master, 2014. https://hdl.handle.net/10216/96650.
Distinctions

Award

2020 Raltegravir no Mundo Real - Menção Honrosa e 2ª prémio
2009 Prof. Manuel Pinheiro Hargreaves - Title of the comunication “Receptor cross-activation by Angiotensin II type-1 receptor antagonists and rosiglitazone in adipocytes and sympathetic nerve endings.”
1995 “Natália Correia” Academic prize

Other distinction

1999 Price for the best ten comunications- O papel da angiotensina II no efeito facilitador da bradicinin