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Sílvia F. Henriques has obtained her BSc degree in Biochemistry in 2008 from Faculdade de Ciências, Universidade de Lisboa, and later in 2010 a Masters degree in Biotechnology by Instituto Superior Técnico, Universidade de Lisboa. She then obtained her PhD degree in Biotechnology and Biosciences in April 2017 from Instituto Superior Técnico, Universidade de Lisboa (Funded by Fundação para a Ciência e Tecnologia, contract: SFRH/BD/78058/2011). She has done a first Post-Doc at the Phenotypic Evolution Group at the Instituto de Investigação e Inovação em Saúde (i3s), Universidade do Porto (May 2017 to Aug 2018) and then moved to a second Post-Doc at the Behavior and Metabolism group at the Champalimaud Foundation where she has been since September of 2018. She has published 9 articles in peer review journals and has been first author in 5 of these publications journals and has also contributed to the writing of 1 book chapter. She has received 2 awards: including one recognizing the merit of her Master's degree. She was also awarded a "Best Poster Award" during the PYFF6 ¿ 6th Conference on physiology of yeast Filamentous fungi (2016). Her interests span from yeast Physiology and Genetics, and Transcriptional regulation (during PhD) to Drosophila genetics, host-Microbiome interactions and Acetobacter Genetics (during her Post-Doc studies). She has visited as scientist different research centres across Europe including the Institute de Genomique Funcionalle de Lyon (2 months) to learn L. plantarum genetics; the Division of Structural Biology (STRUBI, University of Oxford) where she learned to use a high-throughput nano-crystallization (2 weeks); and the Jozef Stefan Institute (Ljubljana) where she had the opportunity to learn about and apply Synthetic Genetic Analysis using an automatized high-throughput system (2 months).
Identification

Personal identification

Full name
Sílvia Catarina Filipe Henriques
Date of birth
1984/07/14
Gender
Female

Citation names

  • Henriques, Sílvia F.

Author identifiers

Ciência ID
FA17-7F22-1291
ORCID iD
0000-0003-2846-1573

Knowledge fields

  • Natural sciences - Biological Sciences

Languages

Language Speaking Reading Writing Listening Peer-review
English Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2) Proficiency (C2)
Portuguese (Mother tongue)
Education
Degree Classification
2017/04/26
Concluded
PhD degree in Biotechnology e Biosciences (Doutoramento)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"Towards the improvement of tolerance to acetic and formic acids in yeast: identification of candidate genes and engineering of the Haa1 transcription factor" (THESIS/DISSERTATION)
Pass with distinction
2010
Concluded
Master's degree Biotechnology (post-Bolonha) (Mestrado)
Universidade de Lisboa Instituto Superior Técnico, Portugal
"The Yeast Transcription Factor Haa1p: identification of amino acid residues and nucleotides essential for functional Haa1-DNA association" (THESIS/DISSERTATION)
17
2008
Concluded
Bachelor's degree in Biochemistry (Licenciatura)
Universidade de Lisboa Faculdade de Ciências, Portugal
"n/a" (THESIS/DISSERTATION)
13
Affiliation

Science

Category
Host institution
Employer
2023/07/01 - 2029/06/30 Contracted Researcher (Research) Fundação Champalimaud, Portugal
2018 - 2023/06/30 Postdoc (Research) Fundação Champalimaud, Portugal
Fundação Champalimaud, Portugal
2017/05/01 - 2018/12/31 Postdoc (Research) Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2010 - 2012 Research Trainee (Research) Instituto de Biotecnologia e Bioengenharia, Portugal
2010/12/03 - 2011/12/31 Researcher (Research) Instituto de Biotecnologia e Bioengenharia, Portugal
Projects

Grant

Designation Funders
2012/01 - 2015/12 The Yeast Transcription Factor Haa1p: from structural studies to transcription machinery engineering
SFRH/BD/78058/2011
PhD Student Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a ciência e Tecnologia

Contract

Designation Funders
2018/09/01 - Current The microbial basis of feeding decisions
Kavli Foundation
Post-doc Fellow
Fundação Champalimaud, Portugal
Kavli Foundation
Ongoing
2018/09 - Current Identifying and testing the metabolites generated by two psychoactive gut bacteria to alter brain function and behavior - MicrobioMetaboBrain
HR-17-00539
Post-doc Fellow
Fundação Champalimaud, Portugal
Obra Social La Caixa
Ongoing
2023/07/01 - 2029/06/30 Identifying the metabolites that mediate the effect of commensal bacteria on food choice in Drosophila melanogaster
2021.01235.CEECIND/CP1675/CT0002
Fundação Champalimaud, Portugal
Fundação para a Ciência e a Tecnologia
Ongoing
2017/05 - 2018/08 Porto Neurosciences and Neurologic Disease Research Initiative at i3S
NORTE-01-0145-FEDER-000008
Post-doc Fellow
Universidade do Porto Instituto de Investigação e Inovação em Saúde, Portugal
2013/03/01 - 2017/05/17 Integral Engineering of Acetic Acid Tolerance in Yeast (INTACT)
PhD Student Fellow
Instituto Superior Técnico , Portugal
European Research Council
2014/02/03 - 2017 Biological physics studies based on Force Feedback Microscopy
PhD Student Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
2014 - 2017 Molecular and Mechanical Forces in Biology measured with Force Atomic Microscopy
PTDC/FIS-NAN/6101/2014
PhD Student Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
2014 - 2017 Structural and functional analysis of the Haa1 transcription factor required for yeast response and resistance to acetic acid
PTDC/BBB-BEP/0385/2014
PhD Student Fellow
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
2014 - 2017 Structural approaches to elucidate the action of Saccharomyces cerevisiae transcription factor Haa1 in the control of the Haa1-signalling pathway under acetic acid stress
INSTRUCT platform (research infrastructure in structural biology)
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
2010/05 - 2011/12 QCMTF -Biosensor platform for transcription factor DNA binding activity detection
PTDC/EBB-EBI/108517/2008
Researcher
Universidade de Lisboa Instituto Superior Técnico, Portugal
Fundação para a Ciência e a Tecnologia
Outputs

Publications

Book chapter
  1. López-Fernández, Hugo; Duque, Pedro; Henriques, Sílvia; Vázquez, Noé; Fdez-Riverola, Florentino; Vieira, Cristina P.; Reboiro-Jato, Miguel; Vieira, Jorge. "A Bioinformatics Protocol for Quickly Creating Large-Scale Phylogenetic Trees". In Practical Applications of Computational Biology and Bioinformatics, 12th International Conference, 88-96. Springer International Publishing, 2018.
    10.1007/978-3-319-98702-6_11
Conference poster
  1. Henriques, Sílvia F.; Dhakan, Darshan; Serra, Lúcia; Francisco, Ana Patrícia; Carvalho-Santos, Zita; Baltazar, Célia; Elias, Ana Paula; et al. "How diet-microbiome-host interactions remodel the fly metabolic landscape, appetite, and physiology". 2023.
  2. Henriques, Sílvia F.; Dhakan, DB; Serra, Lúcia; Francisco, AP; Carvalho-Santos, Zita; Baltazar, Célia; Elias, AP; et al. "Metabolic cross-feeding allows a gut microbial community to overcome detrimental diets and alter host behaviour". Paper presented in 12th FENS Forum of Neuroscience, Virtual Forum, 2020.
  3. Henriques, Sílvia F.; Serra, Lúcia; Francisco, AP; Carvalho-Santos, Z; Baltazar, Célia; Elias, AP; Anjos, Margarida; et al. "How enteric bacteria alter nutrients appetite in Drosophila melonagaster". Paper presented in 9th Champalimaud Research Symposium - Tissue environment in health and disease, Lisbon, Portugal, 2019.
  4. Henriques, Sílvia F.; Mira, NP; Isabel Sá-Correia. "Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to formic acid". Paper presented in 6th Conference on Physiology of Yeasts and Filamentous Fungi, Lisbon, Portugal, 2016.
  5. Henriques, Sílvia F.; Swinnen, S; Shrestha, R; Ho, PW; Sá-Correia, Isabel; Nevoigt, E. "Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: underlying mechanisms". Paper presented in 6th Conference on Physiology of Yeasts and Filamentous Fungi, Lisbon, Portugal, 2016.
  6. Vila Santa, A; Moita, MR; Henriques, Sílvia F.; Frazão, C; Lúcio, JP; Isabel Maria de Sá-Correia Leite de Almeida; Jarboe, LR; Vinga, Susana; Mira, NP. "Exploring a molecular systems biology approach to setup Saccharomyces cerevisiae as a cell factory for the production of itaconic acid". Paper presented in MicroBiotec 15, Évora, 2015.
  7. Vila Santa, A; Moita, MR; Frazão, Carlos; Henriques, Sílvia F.; Sá-Correia, Isabel; Jarboe, LR; Vinga, Susana; Mira, NP. "Exploring a molecular systems biology approach to setup Saccharomyces cerevisiae as a cell factory for the production of itaconic acid". Paper presented in 32nd International Specialized Symposium in Yeasts, Perugia, 2015.
  8. Moita, R; Henriques, Sílvia F.; Isabel Sá-Correia; Mira, NP. "A chemogenomic analysis on Saccharomyces cerevisiae tolerance to itaconic acid". Paper presented in Professsor Nicolau van Uden, Poster P17, Lisboa, 2014.
  9. Mira, NP; Henriques, Sílvia F.; Teixeira, MC; Palma, M; dos Santos, SC; Isabel Sá-Correia. "Haa1p-dependent regulatory network of the yeast response to acetic acid stress". Paper presented in Yeast Genetics and Molecular Biology Meeting, poster 385D, Princeton, United States of America, 2012.
  10. Henriques, Sílvia F.; Mira, NP; Santos, SC; Palma, M; Isabel Sá-Correia. "Haa1p-dependent regulatory network of the yeast response to acetic acid stress.". Paper presented in Systems Biology: Networks, 2011.
  11. Mira, NP; Henriques, Sílvia F.; Keller, G; Windge, DR; Sá-Correia, I. "Role of the Rpd3L histone deacetylase complex in the control of Saccharomyces cerevisiae transcriptional response to acetic acid stress mediated by Haa1p". Paper presented in 9th EMBL Conference on Transcription and Chromatin remodeling, Heidelberg (Book of Abstracts P168), 2010.
  12. Mira, NP; Henriques, Sílvia F.; Keller, G; Matos, Rute; Arraiano, C; Winge, DR; Sá-Correia, I. "Gene expression regulation mediated by the acetic acid-responsive yeast transcription factor Haa1p: DNA binding site and role of copper in DNA binding". Paper presented in XVIII Jornadas de Biologia de Leveduras Professor Nicolau van Uden, 2010.
Journal article
  1. Henriques, Sílvia F.; Dhakan, Darshan B.; Serra, Lúcia; Francisco, Ana Patrícia; Carvalho-Santos, Zita; Baltazar, Célia; Elias, Ana Paula; et al. "Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour". Nature Communications 11 1 (2020): https://doi.org/10.1038/s41467-020-18049-9.
    Open access • Published • 10.1038/s41467-020-18049-9
  2. Ezra-Nevo, Gili; Henriques, Sílvia F; Ribeiro, Carlos (E21F-E9E6-E236). "The diet-microbiome tango: how nutrients lead the gut brain axis". Current Opinion in Neurobiology 62 (2020): 122-132. http://dx.doi.org/10.1016/j.conb.2020.02.005.
    Published • 10.1016/j.conb.2020.02.005
  3. Henriques, Sílvia F.; Serra, Lúcia; Francisco, AP; Carvalho-Santos, Zita; Baltazar, Célia; Elias, AP; Anjos, Margarida; et al. "Metabolic cross-feeding allows a gut microbial community to overcome detrimental diets and alter host behaviour". bioRxiv (2019): https://doi.org/10.1101/821892.
    Open access • Published
  4. Henriques, Sílvia F.; Duque, Pedro; López-Fernández, Hugo; Vázquez, Noé; Fdez-Riverola, Florentino; Reboiro-Jato, Miguel; Vieira, Cristina P.; Vieira, Jorge. "Multiple independent L-gulonolactone oxidase (GULO) gene losses and vitamin C synthesis reacquisition events in non-Deuterostomian animal species". BMC Evolutionary Biology 19 1 (2019): http://dx.doi.org/10.1186/s12862-019-1454-8.
    Open access • Published • 10.1186/s12862-019-1454-8
  5. López-Fernández, Hugo; Duque, Pedro; Henriques, Sílvia; Vázquez, Noé; Fdez-Riverola, Florentino; Vieira, Cristina P.; Reboiro-Jato, Miguel; Vieira, Jorge. "Bioinformatics Protocols for Quickly Obtaining Large-Scale Data Sets for Phylogenetic Inferences". Interdisciplinary Sciences: Computational Life Sciences 11 1 (2018): 1-9. http://dx.doi.org/10.1007/s12539-018-0312-5.
    Published • 10.1007/s12539-018-0312-5
  6. Henriques, Sílvia F.; Mira, Nuno P.; Sá-Correia, Isabel. "Genome-wide search for candidate genes for yeast robustness improvement against formic acid reveals novel susceptibility (Trk1 and positive regulators) and resistance (Haa1-regulon) determinants". Biotechnology for Biofuels 10 1 (2017): http://dx.doi.org/10.1186/s13068-017-0781-5.
    Open access • Published • 10.1186/s13068-017-0781-5
  7. Swinnen S; Henriques SF; Shrestha R; Ho PW; Sá-Correia I; Nevoigt E. "Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms.". Microb Cell Fact 16 7 (2017): https://doi.org/10.1186/s12934-016-0621-5.
    Open access • Published • 10.1186/s12934-016-0621-5
  8. Rodrigues RM; de-Carvalho J; Henriques SF; Mira NP; Sá-Correia I; Ferreira GN. "Transmission line model analysis of transcription factors binding to oligoduplexes - differentiation of the effect of single nucleotide modifications.". (2014): http://europepmc.org/abstract/med/24955439.
    Published • 10.1039/c4an00709c
  9. de-Carvalho J; Rodrigues RM; Tomé B; Henriques SF; Mira NP; Sá-Correia I; Ferreira GN. "Conformational and mechanical changes of DNA upon transcription factor binding detected by a QCM and transmission line model.". (2014): http://europepmc.org/abstract/med/24352369.
    10.1039/c3an01682j
  10. Mira, Nuno P.; Henriques, Sílvia F.; Keller, Greg; Teixeira, Miguel C.; Matos, Rute G.; Arraiano, Cecília M.; Winge, Dennis R.; Sá-Correia, Isabel. "Identification of a DNA-binding site for the transcription factor Haa1, required for Saccharomyces cerevisiae response to acetic acid stress". Nucleic Acids Research 39 16 (2011): 6896-6907. http://dx.doi.org/10.1093/nar/gkr228.
    Published • 10.1093/nar/gkr228
Thesis / Dissertation
  1. Henriques, Sílvia. "Towards the improvement of tolerance to acetic and formic acids in yeast: identification of candidate genes and engineering of the Haa1 transcription factor". PhD, Universidade de Lisboa Instituto Superior Técnico, 2017.
  2. Henriques, Sílvia. "The Yeast Transcription Factor Haa1p: identification of amino acid residues and nucleotides essential for functional Haa1-DNA association". Master, Universidade de Lisboa Instituto Superior Técnico, 2010.
Activities

Oral presentation

Presentation title Event name
Host (Event location)
2023/10/24 How diet-microbiome-host interactions remodel the fly metabolic landscape, appetite, and physiology Champalimaud Research Symposium – The brain within the body within the world, the neuroscience of the self
(Lisboa, Portugal)
2020/12/15 Metabolic cross-feeding in imbalanced diets allows gut microbes to improve reproduction and alter host behaviour 2020 Portuguese Drosophila Meeting
Virtual Forum (Portugal)
2020/06/29 Metabolic cross-feeding allows a gut microbial community to overcome detrimental diets, improve reproduction, and alter host behaviour “Flying through the Gut” seminar series
Virtual Forum
2019/09/29 A syntrophic relationship allows gut bacteria to alter feeding behavior of Drosophila melanogaster Portuguese Drosophila Meeting
(Braga, Portugal)
2018/11/29 L-ascorbate synthesis in non-Bilateria and Protostomian species 7th Annual Meeting
(Póvoa de Varzim, Portugal)
2018/06/20 A Bioinformatics Protocol for Quickly Creating Large-Scale Phylogenetic Trees. , Toledo (Spain), 20-22 June, 2018 12th International Conference on Practical Applications of Computational Biology & Bioinformatics
(Toledo, Spain)
2018/06/14 Evolution of the Vitamin C biosynthetic pathway: role of D. melanogaster Regucalcin and GULO genes in Vit C synthesis and cold acclimation Annual Meeting 2018 Portuguese Society of Genetics
(Porto, Portugal)
2017/11/09 Evolution of the Vitamin C biosynthetic pathway: role of D. melanogaster Regucalcin and GULO genes in Vit C synthesis and cold acclimatization 6th Annual Meeting
(Póvoa de Varzim, Portugal)
2016/12/08 Genome-wide identification of Saccharomyces cerevisiae genes required for tolerance to formic acid XIX National Congress of Biochemistry (SPB2016)
(Guimarães, Portugal)
2016/12/08 Improvement of yeast tolerance to acetic acid through Haa1 transcription factor engineering: towards the underlying mechanisms XIX National Congress of Biochemistry (SPB2016)
(Guimarães, Portugal)
2015/11/13 Genome-wide identification of Saccharomyces cerevisiae genes required for maximal tolerance to itaconic acid Microbial stress: From molecules to systems
(Stiges, Portugal)
2012/06/15 Gene expression regulation in yeast mediated by the transcription factor Haa1p: identification of residues required for functional Haa1-DNA associations and role of copper in DNA-binding XIX Jornadas de Biologia de Leveduras Professor Nicolau van Uden
(Campus de Caparica, Portugal)
2011/12/11 Haa1p-dependent regulatory network of the yeast response to acetic acid stress Microbiotec
(Braga, Portugal)
2011/03/01 Response and Resistance to Drugs and Chemical Stress in the Yeast Model: a Genome­-Wide View 1st National Meeting on Bioengineering
(Oeiras, Portugal)
2011/03/01 Response and Resistance to Drugs and Chemical Stress in the Yeast Model: a Genome-Wide View 1st portuguese meeting in Bioengineering
(Oeiras, Portugal)
Distinctions

Other distinction

2016 Best Poster Award
2010 Merit Diploma (attributed to the best graduating students - from 2008 to 2010)
Universidade de Lisboa Instituto Superior Técnico, Portugal